PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 1MZF 12432100 Human Factor inhibiting HIF (FIH1) in Complex with 2-oxoglutarate 2002-10-07 2002-11-20 Dann III, C.E.,Bruick, R.K.,Deisenhofer, J. Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway. Proc.Natl.Acad.Sci.USA 2002 99 15351 15356 1NVV 12628188 Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS 2003-02-04 2003-04-01 Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J. Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.) 2003 112 685 695 1NVW 12628188 Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS 2003-02-04 2003-04-01 Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J. Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.) 2003 112 685 695 1OPK 12654251 Structural basis for the auto-inhibition of c-Abl tyrosine kinase 2003-03-06 2003-04-08 Nagar, B.,Hantschel, O.,Young, M.A.,Scheffzek, K.,Veach, D.,Bornmann, W.,Clarkson, B.,Superti-Furga, G.,Kuriyan, J. Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.) 2003 112 859 871 1OY6 12738864 Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump 2003-04-03 2003-05-13 Yu, E.W.,McDermott, G.,Zgurskaya, H.I.,Nikaido, H.,Koshland, D.E. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 2003 300 976 980 1OY8 12738864 Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump 2003-04-03 2003-05-13 Yu, E.W.,McDermott, G.,Zgurskaya, H.I.,Nikaido, H.,Koshland, D.E. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 2003 300 976 980 1OY9 12738864 Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump 2003-04-03 2003-05-13 Yu, E.W.,McDermott, G.,Zgurskaya, H.I.,Nikaido, H.,Koshland, D.E. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 2003 300 976 980 1OYD 12738864 Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump 2003-04-03 2003-05-13 Yu, E.W.,McDermott, G.,Zgurskaya, H.I.,Nikaido, H.,Koshland, D.E. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 2003 300 976 980 1OYE 12738864 Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump 2003-04-03 2003-05-13 Yu, E.W.,McDermott, G.,Zgurskaya, H.I.,Nikaido, H.,Koshland, D.E. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 2003 300 976 980 1PKF 12933799 Crystal Structure of Epothilone D-bound Cytochrome P450epoK 2003-06-05 2003-10-28 Nagano, S.,Li, H.,Shimizu, H.,Nishida, C.,Ogura, H.,Ortiz de Montellano, P.R.,Poulos, T.L. Crystal Structures of Epothilone D-bound, Epothilone B-bound, and Substrate-free Forms of Cytochrome P450epoK J.Biol.Chem. 2003 278 44886 44893 1Q5D 12933799 Epothilone B-bound Cytochrome P450epoK 2003-08-06 2003-10-28 Nagano, S.,Li, H.,Shimizu, H.,Nishida, C.,Ogura, H.,Ortiz de Montellano, P.R.,Poulos, T.L. Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK J.Biol.Chem. 2003 278 44886 44893 1Q5E 12933799 Substrate-free Cytochrome P450epoK 2003-08-06 2003-10-28 Nagano, S.,Li, H.,Shimizu, H.,Nishida, C.,Ogura, H.,Ortiz de Montellano, P.R.,Poulos, T.L. Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK J.Biol.Chem. 2003 278 44886 44893 1QYC 13129921 Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases, and their relationship to isoflavone reductases 2003-09-10 2003-11-04 Min, T.,Kasahara, H.,Bedgar, D.L.,Youn, B.,Lawrence, P.K.,Gang, D.R.,Halls, S.C.,Park, H.,Hilsenbeck, J.L.,Davin, L.B.,Lewis, N.G.,Kang, C. Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases. J.Biol.Chem. 2003 278 50714 50723 1QZG 14614509 Crystal structure of Pot1 (protection of telomere)- ssDNA complex 2003-09-16 2003-11-18 Lei, M.,Podell, E.R.,Baumann, P.,Cech, T.R. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA Nature 2003 426 198 203 1QZH 14614509 Crystal structure of Pot1 (protection of telomere)- ssDNA complex 2003-09-16 2003-11-25 Lei, M.,Podell, E.R.,Baumann, P.,Cech, T.R. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA Nature 2003 426 198 203 1R75 Leishmania major hypothetical protein 2003-10-17 2003-12-02 Han, G.W.,Merritt, E.A. LEISHMANIA MAJOR HYPOTHETICAL PROTEIN To be Published 0 0 0 0 1Q9C 14656442 Crystal Structure of the Histone domain of Son of Sevenless 2003-08-24 2003-12-09 Sondermann, H.,Soisson, S.M.,Bar-Sagi, D.,Kuriyan, J. Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless Structure 2003 11 1583 1593 1VJ1 15229897 Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution 2003-12-03 2003-12-09 Levin, I.,Schwarzenbacher, R.,McMullan, D.,Abdubek, P.,Ambing, E.,Biorac, T.,Cambell, J.,Canaves, J.M.,Chiu, H.J.,Dai, X.,Deacon, A.M.,DiDonato, M.,Elsliger, M.A.,Godzik, A.,Grittini, C.,Grzechnik, S.K.,Hampton, E.,Jaroszewski, L.,Karlak, C.,Klock, H.E.,Koesema, E.,Kreusch, A.,Kuhn, P.,Lesley, S.A.,McPhillips, T.M.,Miller, M.D.,Morse, A.,Moy, K.,Ouyang, J.,Page, R.,Quijano, K.,Reyes, R.,Robb, A.,Sims, E.,Spraggon, G.,Stevens, R.C.,van den Bedem, H.,Velasquez, J.,Vincent, J.,von Delft, F.,Wang, X.,West, B.,Wolf, G.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Wilson, I.A. Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution Proteins 2004 56 629 633 1Q5I 14732697 Crystal structure of bacteriorhodopsin mutant P186A crystallized from bicelles 2003-08-07 2004-01-06 Yohannan, S.,Faham, S.,Yang, D.,Whitelegge, J.P.,Bowie, J.U. The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. Proc.Natl.Acad.Sci.USA 2004 101 959 963 1Q5J 14732697 Crystal structure of bacteriorhodopsin mutant P91A crystallized from bicelles 2003-08-07 2004-01-06 Yohannan, S.,Faham, S.,Yang, D.,Whitelegge, J.P.,Bowie, J.U. The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. Proc.Natl.Acad.Sci.USA 2004 101 959 963 1RYN 15567410 Structure of the Chloroplast Group II Intron Splicing Factor CRS2 2003-12-22 2004-01-06 Ostheimer, G.J.,Hadjivasiliou, H.,Kloer, D.P.,Barkan, A.,Matthews, B.W. Structural analysis of the group II intron splicing factor CRS2 yields insights into its protein and RNA interaction surfaces J.Mol.Biol. 2005 345 51 68 1Q2O 14718923 Bovine endothelial nitric oxide synthase N368D mutant heme domain dimer with L-N(omega)-nitroarginine-2,4-L-diaminobutyramide bound 2003-07-25 2004-01-13 Flinspach, M.L.,Li, H.,Jamal, J.,Yang, W.,Huang, H.,Hah, J.M.,Gomez-Vidal, J.A.,Litzinger, E.A.,Silverman, R.B.,Poulos, T.L. Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nat.Struct.Mol.Biol. 2004 11 54 59 1R65 14677973 Crystal structure of ferrous soaked Ribonucleotide Reductase R2 subunit (wildtype) at pH 5 from E. coli 2003-10-14 2004-01-13 Voegtli, W.C.,Sommerhalter, M.,Saleh, L.,Baldwin, J.,Bollinger Jr., J.M.,Rosenzweig, A.C. Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2. J.Am.Chem.Soc. 2003 125 15822 15830 1RZX 15023337 Crystal Structure of a Par-6 PDZ-peptide Complex 2003-12-29 2004-01-27 Peterson, F.C.,Penkert, R.R.,Volkman, B.F.,Prehoda, K.E. Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition. Mol.Cell 2004 13 665 676 1RFF 14761185 Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octapeptide KLNYYDPR, and tetranucleotide AGTT. 2003-11-08 2004-03-02 Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem. 2004 47 829 837 1RFI 14761185 Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, pentapeptide KLNYK, and tetranucleotide AGTC 2003-11-10 2004-03-02 Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem. 2004 47 829 837 1RG1 14761185 Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTT 2003-11-10 2004-03-02 Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem. 2004 47 829 837 1RG2 14761185 Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTA 2003-11-11 2004-03-02 Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem. 2004 47 829 837 1RGT 14761185 Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTC 2003-11-12 2004-03-02 Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem. 2004 47 829 837 1RGU 14761185 The crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTG 2003-11-13 2004-03-02 Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem. 2004 47 829 837 1RH0 14761185 Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine and trinucleotide GTT 2003-11-13 2004-03-02 Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem. 2004 47 829 837 1S51 14982414 Thr24Ser Bacteriorhodopsin 2004-01-19 2004-03-02 Yohannan, S.,Faham, S.,Yang, D.,Grosfeld, D.,Chamberlain, A.K.,Bowie, J.U. A C(alpha)-H.O Hydrogen Bond in a Membrane Protein Is Not Stabilizing J.Am.Chem.Soc. 2004 126 2284 2285 1S52 14982414 Thr24Val Bacteriorhodopsin 2004-01-19 2004-03-02 Yohannan, S.,Faham, S.,Yang, D.,Grosfeld, D.,Chamberlain, A.K.,Bowie, J.U. A C(alpha)-H.O Hydrogen Bond in a Membrane Protein Is Not Stabilizing J.Am.Chem.Soc. 2004 126 2284 2285 1S53 14982414 Thr46Ser Bacteriorhodopsin 2004-01-19 2004-03-02 Yohannan, S.,Faham, S.,Yang, D.,Grosfeld, D.,Chamberlain, A.K.,Bowie, J.U. A C(alpha)-H.O Hydrogen Bond in a Membrane Protein Is Not Stabilizing J.Am.Chem.Soc. 2004 126 2284 2285 1S54 14982414 Thr24Ala Bacteriorhodopsin 2004-01-19 2004-03-02 Yohannan, S.,Faham, S.,Yang, D.,Grosfeld, D.,Chamberlain, A.K.,Bowie, J.U. A C(alpha)-H.O Hydrogen Bond in a Membrane Protein Is Not Stabilizing J.Am.Chem.Soc. 2004 126 2284 2285 1VJ0 Crystal structure of Alcohol dehydrogenase (TM0436) from Thermotoga maritima at 2.00 A resolution 2003-12-02 2004-03-02 Joint Center for Structural Genomics (JCSG) Crystal structure of Alcohol dehydrogenase (TM0436) from Thermotoga maritima at 2.00 A resolution To be published 0 0 0 0 1PZJ 14980603 Cholera Toxin B-Pentamer Complexed With Nitrophenyl Galactoside 5 2003-07-11 2004-03-09 Mitchell, D.D.,Pickens, J.C.,Korotkov, K.,Fan, E.,Hol, W.G.J. 3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies Bioorg.Med.Chem. 2004 12 907 920 1SIX 15276840 Mycobacterium tuberculosis dUTPase complexed with magnesium and alpha,beta-imido-dUTP 2004-03-01 2004-03-09 Chan, S.,Segelke, B.,Lekin, T.,Krupka, H.,Cho, U.S.,Kim, M.-Y.,So, M.,Kim, C.-Y.,Naranjo, C.M.,Rogers, Y.C.,Park, M.S.,Waldo, G.S.,Pashkov, I.,Cascio, D.,Perry, J.L.,Sawaya, M.R. Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J.Mol.Biol. 2004 341 503 517 1SJN 15276840 Mycobacterium tuberculosis dUTPase complexed with magnesium and alpha,beta-imido-dUTP 2004-03-04 2004-03-09 Chan, S.,Segelke, B.,Lekin, T.,Krupka, H.,Cho, U.S.,Kim, M.-Y.,So, M.,Kim, C.-Y.,Naranjo, C.M.,Rogers, Y.C.,Park, M.S.,Waldo, G.S.,Pashkov, I.,Cascio, D.,Perry, J.L.,Sawaya, M.R. Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J.Mol.Biol. 2004 341 503 517 1VJF CRYSTAL STRUCTURE OF A PUTATIVE DNA-BINDING PROTEIN (CC_0111) FROM CAULOBACTER CRESCENTUS CB15 AT 1.62 A RESOLUTION 2004-02-11 2004-03-09 Joint Center for Structural Genomics (JCSG) Crystal structure of putative DNA-binding protein from Caulobacter crescentus at 1.62 A resolution To be published 0 0 0 0 1RKU 14699121 Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa 2003-11-23 2004-03-30 Singh, S.K.,Yang, K.,Karthikeyan, S.,Huynh, T.,Zhang, X.,Phillips, M.A.,Zhang, H. The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity. J.Biol.Chem. 2004 279 13166 13173 1VJR Crystal structure of 4-nitrophenylphosphatase (TM1742) from Thermotoga maritima at 2.40 A resolution 2004-03-22 2004-03-30 Joint Center for Structural Genomics (JCSG) Crystal structure of 4-nitrophenylphosphatase (TM1742) from Thermotoga maritima at 2.40 A resolution To be published 0 0 0 0 1S5E 15049684 Cholera holotoxin, Crystal form 1 2004-01-20 2004-04-06 O'Neal, C.J.,Amaya, E.I.,Jobling, M.G.,Holmes, R.K.,Hol, W.G. Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism Biochemistry 2004 43 3772 3782 1S5F 15049684 Cholera holotoxin, Crystal form 2 2004-01-20 2004-04-06 O'Neal, C.J.,Amaya, E.I.,Jobling, M.G.,Holmes, R.K.,Hol, W.G. Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism Biochemistry 2004 43 3772 3782 1UV7 15081815 periplasmic domain of EpsM from Vibrio cholerae 2004-01-15 2004-04-23 Abendroth, J.,Rice, A.,Mcluskey, K.,Bagdasarian, M.,Hol, W.G.J. The Crystal Structure of the Periplasmic Domain of the Type II Secretion System Protein Epsm from Vibrio Cholerae: The Simplest Version of the Ferredoxin Fold J.Mol.Biol. 2004 338 585 0 1SJ4 15141216 Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution 2004-03-02 2004-05-18 Ke, A.,Zhou, K.,Ding, F.,Cate, J.H.,Doudna, J.A. A Conformational Switch controls hepatitis delta virus ribozyme catalysis Nature 2004 429 201 205 1SJF 15141216 Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Cobalt Hexammine solution 2004-03-03 2004-05-18 Ke, A.,Zhou, K.,Ding, F.,Cate, J.H.,Doudna, J.A. A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature 2004 429 201 205 1VBX 15141216 Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in EDTA solution 2004-03-03 2004-05-18 Ke, A.,Zhou, K.,Ding, F.,Cate, J.H.D.,Doudna, J.A. A Conformational Switch controls hepatitis delta virus ribozyme catalysis NATURE 2004 429 201 205 1VC6 15141216 Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Product with C75U Mutaion, cleaved in Imidazole and Mg2+ solutions 2004-03-04 2004-05-18 Ke, A.,Zhou, K.,Ding, F.,Cate, J.H.D.,Doudna, J.A. A Conformational Switch controls hepatitis delta virus ribozyme catalysis NATURE 2004 429 201 205 1TC5 Structural Analysis of a probable eukaryotic D-amino acid tRNA deacylase 2004-05-20 2004-06-08 Robien, M.A.,Hol, W.G.J.,Structural Genomics of Pathogenic Protozoa Consortium Structural analysis of LMAJ005534AAA, a probable eukaryotic D-amino acid tRNA deacylase from Leishmania major To be Published 0 0 0 0 1VKI Crystal structure of a putative oligo-nucleotide binding protein (atu3699, agr_l_2275) from agrobacterium tumefaciens str. c58 at 1.60 A resolution 2004-05-24 2004-06-08 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (ATU3699) from Agrobacterium tumefaciens at 1.60 A resolution To be published 0 0 0 0 1SL5 15195147 Crystal Structure of DC-SIGN carbohydrate recognition domain complexed with LNFP III (Dextra L504). 2004-03-05 2004-06-15 Guo, Y.,Feinberg, H.,Conroy, E.,Mitchell, D.A.,Alvarez, R.,Blixt, O.,Taylor, M.E.,Weis, W.I.,Drickamer, K. Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR Nat.Struct.Mol.Biol. 2004 11 591 598 1SL6 15195147 Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x. 2004-03-05 2004-06-15 Guo, Y.,Feinberg, H.,Conroy, E.,Mitchell, D.A.,Alvarez, R.,Blixt, O.,Taylor, M.E.,Weis, W.I.,Drickamer, K. Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR Nat.Struct.Mol.Biol. 2004 11 591 598 1SXJ 15201901 Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA) 2004-03-30 2004-06-22 Bowman, G.D.,O'Donnell, M.,Kuriyan, J. Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature 2004 429 724 730 1SXJ 15201901 Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA) 2004-03-30 2004-06-22 Bowman, G.D.,O'Donnell, M.,Kuriyan, J. Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature 2004 429 724 730 1VKM 15822122 Crystal structure of an indigoidine synthase a (idga)-like protein (tm1464) from thermotoga maritima msb8 at 1.90 A resolution 2004-06-09 2004-06-29 Levin, I.,Miller, M.D.,Schwarzenbacher, R.,McMullan, D.,Abdubek, P.,Ambing, E.,Biorac, T.,Cambell, J.,Canaves, J.M.,Chiu, H.J.,Deacon, A.M.,DiDonato, M.,Elsliger, M.A.,Godzik, A.,Grittini, C.,Grzechnik, S.K.,Hale, J.,Hampton, E.,Han, G.W.,Haugen, J.,Hornsby, M.,Jaroszewski, L.,Karlak, C.,Klock, H.E.,Koesema, E.,Kreusch, A.,Kuhn, P.,Lesley, S.A.,Morse, A.,Moy, K.,Nigoghossian, E.,Ouyang, J.,Page, R.,Quijano, K.,Reyes, R.,Robb, A.,Sims, E.,Spraggon, G.,Stevens, R.C.,van den Bedem, H.,Velasquez, J.,Vincent, J.,Wang, X.,West, B.,Wolf, G.,Xu, Q.,Zagnitko, O.,Hodgson, K.O.,Wooley, J.,Wilson, I.A. Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold. Proteins 2005 59 864 868 1RL3 15274925 Crystal structure of cAMP-free R1a subunit of PKA 2003-11-24 2004-07-06 Wu, J.,Brown, S.,Xuong, N.H.,Taylor, S.S. RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure 2004 12 1057 1065 1T6U 15209499 Nickel Superoxide Dismutase (NiSOD) Native 1.30 A Structure 2004-05-07 2004-07-13 Barondeau, D.P.,Kassmann, C.J.,Bruns, C.K.,Tainer, J.A.,Getzoff, E.D. Nickel superoxide dismutase structure and mechanism. Biochemistry 2004 43 8038 8047 1PPJ 16024040 Bovine cytochrome bc1 complex with stigmatellin and antimycin 2003-06-16 2004-07-20 Huang, L.S.,Cobessi, D.,Tung, E.Y.,Berry, E.A. Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc(1) Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-bonding Pattern. J.Mol.Biol. 2005 351 573 597 1TEX 15258569 Mycobacterium smegmatis Stf0 Sulfotransferase with Trehalose 2004-05-25 2004-07-20 Mougous, J.D.,Petzold, C.J.,Senaratne, R.H.,Lee, D.H.,Akey, D.L.,Lin, F.L.,Munchel, S.E.,Pratt, M.R.,Riley, L.W.,Leary, J.A.,Berger, J.M.,Bertozzi, C.R. Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat.Struct.Mol.Biol. 2004 11 721 729 1SV0 15260987 Crystal Structure Of Yan-SAM/Mae-SAM Complex 2004-03-26 2004-07-27 Qiao, F.,Song, H.,Kim, C.A.,Sawaya, M.R.,Hunter, J.B.,Gingery, M.,Rebay, I.,Courey, A.J.,Bowie, J.U. Derepression by depolymerization; structural insights into the regulation of yan by mae. Cell(Cambridge,Mass.) 2004 118 163 173 1T0Q 15096510 Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase 2004-04-12 2004-07-27 Sazinsky, M.H.,Bard, J.,Di Donato, A.,Lippard, S.J. Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES. J.Biol.Chem. 2004 279 30600 30610 1T0R 15096510 Crystal Structure of the Toluene/o-xylene Monooxygenase Hydroxuylase from Pseudomonas stutzeri-azide bound 2004-04-12 2004-07-27 Sazinsky, M.H.,Bard, J.,Di Donato, A.,Lippard, S.J. Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES. J.Biol.Chem. 2004 279 30600 30610 1T0S 15096510 Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase with 4-bromophenol bound 2004-04-12 2004-07-27 Sazinsky, M.H.,Bard, J.,Di Donato, A.,Lippard, S.J. Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1: INSIGHT INTO THE SUBSTRATE SPECIFICITY, SUBSTRATE CHANNELING, AND ACTIVE SITE TUNING OF MULTICOMPONENT MONOOXYGENASES. J.Biol.Chem. 2004 279 30600 30610 1S4Y 15304227 Crystal structure of the activin/actrIIb extracellular domain 2004-01-19 2004-08-10 Greenwald, J.,Vega, M.E.,Allendorph, G.P.,Fischer, W.H.,Vale, W.,Choe, S. A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-beta Family Receptors. Mol.Cell 2004 15 485 489 1VKY 15822125 Crystal structure of S-adenosylmethionine tRNA ribosyltransferase (TM0574) from Thermotoga maritima at 2.00 A resolution 2004-06-28 2004-08-17 Mathews, I.,Schwarzenbacher, R.,McMullan, D.,Abdubek, P.,Ambing, E.,Axelrod, H.,Biorac, T.,Canaves, J.M.,Chiu, H.J.,Deacon, A.M.,DiDonato, M.,Elsliger, M.A.,Godzik, A.,Grittini, C.,Grzechnik, S.K.,Hale, J.,Hampton, E.,Han, G.W.,Haugen, J.,Hornsby, M.,Jaroszewski, L.,Klock, H.E.,Koesema, E.,Kreusch, A.,Kuhn, P.,Lesley, S.A.,Levin, I.,Miller, M.D.,Moy, K.,Nigoghossian, E.,Ouyang, J.,Paulsen, J.,Quijano, K.,Reyes, R.,Spraggon, G.,Stevens, R.C.,van den Bedem, H.,Velasquez, J.,Vincent, J.,White, A.,Wolf, G.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Wilson, I.A. Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. Proteins 2005 59 869 874 1TUE 15289463 The X-ray Structure of the Papillomavirus Helicase in Complex with its Molecular Matchmaker E2 2004-06-24 2004-08-24 Abbate, E.A.,Berger, J.M.,Botchan, M.R. The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2 Genes Dev. 2004 18 1981 1996 1VLP 16154095 Crystal structure of a putative nicotinate phosphoribosyltransferase (yor209c, npt1) from saccharomyces cerevisiae at 1.75 A resolution 2004-08-06 2004-08-24 Chappie, J.S.,Canaves, J.M.,Han, G.W.,Rife, C.L.,Xu, Q.,Stevens, R.C. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure 2005 13 1385 1396 1U55 15326296 Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex) 2004-07-27 2004-08-31 Pellicena, P.,Karow, D.S.,Boon, E.M.,Marletta, M.A.,Kuriyan, J. Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc.Natl.Acad.Sci.Usa 2004 101 12854 12859 1U56 15326296 Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (Water-ligated, ferric form) 2004-07-27 2004-08-31 Pellicena, P.,Karow, D.S.,Boon, E.M.,Marletta, M.A.,Kuriyan, J. Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc.Natl.Acad.Sci.Usa 2004 101 12854 12859 1RII 15735341 Crystal structure of phosphoglycerate mutase from M. Tuberculosis 2003-11-17 2004-10-05 Muller, P.,Sawaya, M.R.,Pashkov, I.,Chan, S.,Nguyen, C.,Wu, Y.,Perry, L.J.,Eisenberg, D. The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase. Acta Crystallogr.,Sect.D 2005 61 309 315 1U8R 15351642 Crystal Structure of an IdeR-DNA Complex Reveals a Conformational Change in Activated IdeR for Base-specific Interactions 2004-08-06 2004-10-05 Wisedchaisri, G.,Holmes, R.K.,Hol, W.G.J. Crystal Structure of an IdeR-DNA Complex Reveals a Conformational Change in Activated IdeR for Base-specific Interactions. J.Mol.Biol. 2004 342 1155 1169 1TN0 15312757 Structure of bacterorhodopsin mutant A51P 2004-06-11 2004-10-12 Yohannan, S.,Yang, D.,Faham, S.,Boulting, G.,Whitelegge, J.,Bowie, J.U. Proline substitutions are not easily accommodated in a membrane protein J.Mol.Biol. 2004 341 1 6 1U5V Structure of CitE complexed with triphosphate group of ATP form Mycobacterium tuberculosis 2004-07-28 2004-10-12 Goulding, C.W.,Lerkin, T.,Kim, C.Y.,Segelke, B.,Terwilliger, T.,Eisenberg, E. Crystal structure of Mycobacterium tuberculosis citrate lyase beta subunit and its unusual triphosphate binding site To be Published 0 0 0 0 1XDY 15355966 Structural and Biochemical Identification of a Novel Bacterial Oxidoreductase, W-containing cofactor 2004-09-08 2004-10-12 Loschi, L.,Brokx, S.J.,Hills, T.L.,Zhang, G.,Bertero, M.G.,Lovering, A.L.,Weiner, J.H.,Strynadka, N.C. Structural and biochemical identification of a novel bacterial oxidoreductase. J.Biol.Chem. 2004 279 50391 50400 1XN4 16199669 PUTATIVE MAR1 RIBONUCLEASE FROM LEISHMANIA MAJOR 2004-10-04 2004-10-12 Caruthers, J.,Zucker, F.,Worthey, E.,Myler, P.J.,Buckner, F.,Van Voorhuis, W.,Mehlin, C.,Boni, E.,Feist, T.,Luft, J.,Gulde, S.,Lauricella, A.,Kaluzhniy, O.,Anderson, L.,Le Trong, I.,Holmes, M.A.,Earnest, T.,Soltis, M.,Hodgson, K.O.,Hol, W.G.,Merritt, E.A. Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci. 2005 14 2887 2894 1TN5 15312757 Structure of bacterorhodopsin mutant K41P 2004-06-11 2004-10-19 Yohannan, S.,Yang, D.,Faham, S.,Boulting, G.,Whitelegge, J.,Bowie, J.U. Proline substitutions are not easily accommodated in a membrane protein J.Mol.Biol. 2004 341 1 6 1RCV 15380181 Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1 2003-11-04 2004-10-26 Pickens, J.C.,Mitchell, D.D.,Liu, J.,Tan, X.,Zhang, Z.,Verlinde, C.L.,Hol, W.G.,Fan, E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chem.Biol. 2004 11 1205 1215 1RD9 15380181 Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV2 2003-11-05 2004-10-26 Pickens, J.C.,Mitchell, D.D.,Liu, J.,Tan, X.,Zhang, Z.,Verlinde, C.L.,Hol, W.G.,Fan, E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chem.Biol. 2004 11 1205 1215 1RDP 15380181 Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV3 2003-11-05 2004-10-26 Pickens, J.C.,Mitchell, D.D.,Liu, J.,Tan, X.,Zhang, Z.,Verlinde, C.L.,Hol, W.G.,Fan, E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chem.Biol. 2004 11 1205 1215 1RF2 15380181 Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV4 2003-11-07 2004-10-26 Pickens, J.C.,Mitchell, D.D.,Liu, J.,Tan, X.,Zhang, Z.,Verlinde, C.L.,Hol, W.G.,Fan, E. Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chem.Biol. 2004 11 1205 1215 1XD4 15507210 Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) 2004-09-03 2004-11-02 Sondermann, H.,Soisson, S.M.,Boykevisch, S.,Yang, S.S.,Bar-Sagi, D.,Kuriyan, J. Structural analysis of autoinhibition in the ras activator son of sevenless. Cell(Cambridge,Mass.) 2004 119 393 405 1X8W 15525509 Structure of the Tetrahymena Ribozyme: Base Triple Sandwich and Metal Ion at the Active Site 2004-08-18 2004-11-09 Guo, F.,Gooding, A.R.,Cech, T.R. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Mol.Cell 2004 16 351 362 1XTP Structural Analysis of Leishmania major LMAJ004091AAA, a SAM-dependent methyltransferase of the DUF858/Pfam05891 family 2004-10-22 2004-11-09 Robien, M.A.,Hol, W.G.J.,Structural Genomics of Pathogenic Protozoa Consortium Structural Analysis of Leishmania major LMAJ004091AAA To be Published 0 0 0 0 1XAR 15509576 Crystal Structure of a fragment of DC-SIGNR (containing the carbohydrate recognition domain and two repeats of the neck). 2004-08-26 2004-11-16 Feinberg, H.,Guo, Y.,Mitchell, D.A.,Drickamer, K.,Weis, W.I. Extended Neck Regions Stabilize Tetramers of the Receptors DC-SIGN and DC-SIGNR J.Biol.Chem. 2005 280 1327 1335 1XED 15530357 Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 2004-09-10 2004-11-23 Hamburger, A.E.,West Jr., A.P.,Bjorkman, P.J. Crystal Structure of a Polymeric Immunoglobulin Binding Fragment of the Human Polymeric Immunoglobulin Receptor Structure 2004 12 1925 1935 1XXH 15556993 ATPgS Bound E. Coli Clamp Loader Complex 2004-11-05 2004-12-07 Kazmirski, S.L.,Podobnik, M.,Weitze, T.F.,O'donnell, M.,Kuriyan, J. Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex Proc.Natl.Acad.Sci.USA 2004 101 16750 16755 1XXI 15556993 ADP Bound E. coli Clamp Loader Complex 2004-11-05 2004-12-07 Kazmirski, S.L.,Podobnik, M.,Weitze, T.F.,O'donnell, M.,Kuriyan, J. Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex Proc.Natl.Acad.Sci.USA 2004 101 16750 16755 1XJV 15558049 Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG) 2004-09-25 2004-12-14 Lei, M.,Podell, E.R.,Cech, T.R. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection Nat.Struct.Mol.Biol. 2004 11 1223 1229 1XJV 15558049 Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG) 2004-09-25 2004-12-14 Lei, M.,Podell, E.R.,Cech, T.R. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection Nat.Struct.Mol.Biol. 2004 11 1223 1229 1XJV 15558049 Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG) 2004-09-25 2004-12-14 Lei, M.,Podell, E.R.,Cech, T.R. 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J.Struct.Biol. 2004 148 205 213 1Y67 Crystal Structure of Manganese Superoxide Dismutase from Deinococcus radiodurans 2004-12-03 2004-12-21 Chan, S.,Tanaka, S.,Sawaya, M.R.,Perry, L.J. Crystal Structure of Manganese Superoxide Dismutase from Deinococcus radiodurans To be Published 0 0 0 0 1XOU 15619638 Crystal structure of the CesA-EspA complex 2004-10-06 2004-12-28 Yip, C.K.,Finlay, B.B.,Strynadka, N.C.J. Structural characterization of a type III secretion system filament protein in complex with its chaperone. Nat.Struct.Mol.Biol. 2005 12 75 81 1V18 15327768 The crystal structure of beta-catenin armadillo repeat complexed with a phosphorylated APC 20mer repeat. 2004-04-09 2005-01-12 Ha, N.-C.,Tonozuka, T.,Stamos, J.L.,Weis, W.I. Mechanism of Phosphorylation-Dependent Binding of Apc to Beta-Catenin and its Role in Beta-Catenin Degradation Mol.Cell 2004 15 511 0 1RKI 16111437 Structure of pag5_736 from P. aerophilum with three disulphide bonds 2003-11-21 2005-01-18 Beeby, M.,Ryttersgaard, C.,Boutz, D.R.,Perry, L.J.,Yeates, T.O. The Genomics of Disulfide Bonding and Protein Stabilization in Thermophiles. Plos Biol. 2005 3 0 0 1VQU Crystal structure of Anthranilate phosphoribosyltransferase 2 (17130499) from Nostoc sp. at 1.85 A resolution 2005-01-05 2005-01-18 Joint Center for Structural Genomics (JCSG) Crystal structure of Anthranilate phosphoribosyltransferase 2 (17130499) from Nostoc sp. at 1.85 A resolution To be published 0 0 0 0 1WNH 15698574 Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor) 2004-08-04 2005-02-15 Aagaard, A.,Listwan, P.,Cowieson, N.,Huber, T.,Ravasi, T.,Wells, C.A.,Flanagan, J.U.,Kellie, S.,Hume, D.A.,Kobe, B.,Martin, J.L. An Inflammatory Role for the Mammalian Carboxypeptidase Inhibitor Latexin: Relationship to Cystatins and the Tumor Suppressor TIG1 Structure 2005 13 309 317 1XIY 15701514 Crystal Structure of Plasmodium falciparum antioxidant protein (1-Cys peroxiredoxin) 2004-09-22 2005-02-15 Sarma, G.N.,Nickel, C.,Rahlfs, S.,Fischer, M.,Becker, K.,Karplus, P.A. Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin. J.Mol.Biol. 2005 346 1021 1034 1YF2 15728358 Three-dimensional structure of DNA sequence specificity (S) subunit of a type I restriction-modification enzyme and its functional implications 2004-12-30 2005-02-15 Kim, J.S.,Degiovanni, A.,Jancarik, J.,Adams, P.D.,Yokota, H.,Kim, R.,Kim, S.H. Crystal structure of DNA sequence specificity subunit of a type I restriction-modification enzyme and its functional implications. Proc.Natl.Acad.Sci.USA 2005 102 3248 3253 1Y5L 15615728 The crystal structure of the NarGHI mutant NarI-H66Y 2004-12-02 2005-03-08 Bertero, M.G.,Rothery, R.A.,Boroumand, N.,Palak, M.,Blasco, F.,Ginet, N.,Weiner, J.H.,Strynadka, N.C.J. Structural and Biochemical Characterization of a Quinol Binding Site of Escherichia coli Nitrate Reductase A J.Biol.Chem. 2005 280 14836 14843 2BKL 15738423 Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Inter-Domain Dynamics in Catalysis and Specificity 2005-02-16 2005-03-09 Shan, L.,Mathews, I.I.,Khosla, C. Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity Proc.Natl.Acad.Sci.USA 2005 102 3599 0 1XM9 15663951 Structure of the armadillo repeat domain of plakophilin 1 2004-10-01 2005-03-22 Choi, H.J.,Weis, W.I. Structure of the armadillo repeat domain of plakophilin 1. J.Mol.Biol. 2005 346 367 376 1YVL 15780933 Structure of Unphosphorylated STAT1 2005-02-16 2005-03-22 Mao, X.,Ren, Z.,Parker, G.N.,Sondermann, H.,Pastorello, M.A.,Wang, W.,McMurray, J.S.,Demeler, B.,Darnell, J.E.,Chen, X. Structural bases of unphosphorylated STAT1 association and receptor binding. Mol.Cell 2005 17 761 771 1YT5 16511117 Crystal structure of NAD kinase from Thermotoga maritima 2005-02-09 2005-04-05 Oganesyan, V.,Huang, C.,Adams, P.D.,Jancarik, J.,Yokota, H.A.,Kim, R.,Kim, S.H. Structure of a NAD kinase from Thermotoga maritima at 2.3 A resolution. Acta Crystallogr.,Sect.F 2005 61 640 646 1S3Q 15837202 Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus 2004-01-13 2005-04-12 Johnson, E.,Cascio, D.,Sawaya, M.R.,Gingery, M.,Schroder, I. Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon Archaeoglobus fulgidus. Structure 2005 13 637 648 1SVD The structure of Halothiobacillus neapolitanus RuBisCo 2004-03-29 2005-04-12 Kerfeld, C.A.,Sawaya, M.R.,Pashkov, I.,Cannon, G.,Williams, E.,Tran, K.,Yeates, T.O. The structure of Halothiobacillus neapolitanus RuBisCo To be Published 0 0 0 0 1Z8F Guanylate Kinase Double Mutant A58C, T157C from Mycobacterium tuberculosis (Rv1389) 2005-03-30 2005-04-12 Chan, S.,Sawaya, M.R.,Choi, B.,Zocchi, G.,Perry, L.J. Crystal Structure of Guanylate Kinase from Mycobacterium tuberculosis (Rv1389) To be Published 0 0 0 0 1XJI 15689517 Bacteriorhodopsin crystallized in bicelles at room temperature 2004-09-23 2005-04-19 Faham, S.,Boulting, G.L.,Massey, E.A.,Yohannan, S.,Yang, D.,Bowie, J.U. Crystallization of bacteriorhodopsin from bicelle formulations at room temperature Protein Sci. 2005 14 836 840 1Z0U 16242716 Crystal structure of a NAD kinase from Archaeoglobus fulgidus bound by NADP 2005-03-02 2005-04-19 Liu, J.,Lou, Y.,Yokota, H.,Adams, P.D.,Kim, R.,Kim, S.H. Crystal Structures of an NAD Kinase from Archaeoglobus fulgidus in Complex with ATP, NAD, or NADP J.Mol.Biol. 2005 354 289 303 1Z8H CRYSTAL STRUCTURE OF a GDSL-like lipase (ALR1529) FROM NOSTOC SP. PCC 7120 AT 2.02 A RESOLUTION 2005-04-11 2005-04-19 Joint Center for Structural Genomics (JCSG) Crystal structure of Putative lipase from the G-D-S-L family (17135349) from Nostoc sp. PCC 7120 at 2.02 A resolution To be published 0 0 0 0 1Z8L 15837926 Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase 2005-03-30 2005-04-19 Davis, M.I.,Bennett, M.J.,Thomas, L.M.,Bjorkman, P.J. Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase Proc.Natl.Acad.Sci.USA 2005 102 5981 5986 1YJ9 15851032 Crystal Structure Of The Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui Containing a three residue deletion in L22 2005-01-13 2005-04-26 Tu, D.,Blaha, G.,Moore, P.B.,Steitz, T.A. Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.) 2005 121 257 270 1Z0Z 16242716 Crystal structure of a NAD kinase from Archaeoglobus fulgidus in complex with NAD 2005-03-02 2005-04-26 Liu, J.,Lou, Y.,Yokota, H.,Adams, P.D.,Kim, R.,Kim, S.H. Crystal Structures of an NAD Kinase from Archaeoglobus fulgidus in Complex with ATP, NAD, or NADP J.Mol.Biol. 2005 354 289 303 2BLF 15863498 Sulfite dehydrogenase from Starkeya Novella 2005-03-04 2005-04-28 Kappler, U.,Bailey, S. Molecular Basis of Intramolecular Electron Transfer in Sulfite-Oxidizing Enzymes is Revealed by High Resolution Structure of a Heterodimeric Complex of the Catalytic Molybdopterin Subunit and a C-Type Cytochrome Subunit. J.Biol.Chem. 2005 280 24999 0 2BH1 15843017 X-ray structure of the general secretion pathway complex of the N- terminal domain of EpsE and the cytosolic domain of EpsL of Vibrio cholerae 2005-01-06 2005-05-13 Abendroth, J.,Murphy, P.M.,Mushtaq, A.,Bagdasarian, M.,Sandkvist, M.,Hol, W.G.J. The X-Ray Structure of the Type II Secretion System Complex Formed by the N-Terminal Domain of Epse and the Cytoplasmic Domain of Epsl of Vibrio Cholerae J.Mol.Biol. 2005 348 845 0 1YKW 15893668 Crystal Structure of a Novel RuBisCO-Like Protein from the Green Sulfur Bacterium Chlorobium tepidum 2005-01-18 2005-05-17 Li, H.,Sawaya, M.R.,Tabita, F.R.,Eisenberg, D. Crystal structure of a RuBisCO-like protein from the green sulfur bacterium Chlorobium tepidum. Structure 2005 13 779 789 1Y1N 15882055 Identification of SH3 motif in M. 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High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins. J.Biol.Inorg.Chem. 2005 10 407 416 1YUZ 15895271 Partially Reduced State of Nigerythrin 2005-02-14 2005-06-21 Iyer, R.B.,Silaghi-Dumitrescu, R.,Kurtz, D.M.,Lanzilotta, W.N. High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins. J.Biol.Inorg.Chem. 2005 10 407 416 1ZUP CRYSTAL STRUCTURE OF A PUTATIVE NUCLEASE WITH A RIBONUCLEASE H-LIKE MOTIF FOLD (TM1739) FROM THERMOTOGA MARITIMA AT 2.20 A RESOLUTION 2005-05-31 2005-06-21 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (tm1739) from Thermotoga maritima at 2.20 A resolution To be published 0 0 0 0 2A03 Superoxide dismutase protein from plasmodium berghei 2005-06-15 2005-06-21 Holmes, M.A.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) Hypothetical protein from plasmodium berghei To be published 0 0 0 0 1Z5L 16007091 Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D 2005-03-18 2005-07-19 Zajonc, D.M.,Cantu, C.,Mattner, J.,Zhou, D.,Savage, P.B.,Bendelac, A.,Wilson, I.A.,Teyton, L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat.Immunol. 2005 6 810 818 2A65 16041361 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters 2005-07-01 2005-08-02 Yamashita, A.,Singh, S.K.,Kawate, T.,Jin, Y.,Gouaux, E. Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters. Nature 2005 437 215 223 2A65 16041361 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters 2005-07-01 2005-08-02 Yamashita, A.,Singh, S.K.,Kawate, T.,Jin, Y.,Gouaux, E. Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters. Nature 2005 437 215 223 2A9V Crystal structure of a putative gmp synthase subunit a protein (ta0944m) from thermoplasma acidophilum at 2.45 A resolution 2005-07-12 2005-08-02 Joint Center for Structural Genomics (JCSG) Crystal structure of (np_394403.1) from THERMOPLASMA ACIDOPHILUM at 2.45 A resolution To be published 0 0 0 0 1XHM 16060668 The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer 2004-09-20 2005-08-09 Davis, T.L.,Bonacci, T.M.,Sprang, S.R.,Smrcka, A.V. Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein betagamma Subunits. Biochemistry 2005 44 10593 10604 1ZJR 16511140 Crystal Structure of A. aeolicus TrmH/SpoU tRNA modifying enzyme 2005-04-30 2005-08-09 Pleshe, E.,Truesdell, J.,Batey, R.T. Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus. Acta Crystallogr.,Sect.F 2005 61 722 728 2A10 16081736 carboxysome shell protein ccmK4 2005-06-17 2005-08-09 Kerfeld, C.A.,Sawaya, M.R.,Tanaka, S.,Nguyen, C.V.,Phillips, M.,Beeby, M.,Yeates, T.O. Protein structures forming the shell of primitive bacterial organelles Science 2005 309 936 938 2A5D 16099990 Structural basis for the activation of cholera toxin by human ARF6-GTP 2005-06-30 2005-08-16 O'Neal, C.J.,Jobling, M.G.,Holmes, R.K.,Hol, W.G. Structural basis for the activation of cholera toxin by human ARF6-GTP. Science 2005 309 1093 1096 2A5G 16099990 Cholera toxin A1 subunit bound to ARF6(Q67L) 2005-06-30 2005-08-16 O'Neal, C.J.,Jobling, M.G.,Holmes, R.K.,Hol, W.G. Structural basis for the activation of cholera toxin by human ARF6-GTP. Science 2005 309 1093 1096 2A5X 16141336 Crystal Structure of a Cross-linked Actin Dimer 2005-07-01 2005-08-23 Kudryashov, D.S.,Sawaya, M.R.,Adisetiyo, H.,Norcross, T.,Hegyi, G.,Reisler, E.,Yeates, T.O. The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin Proc.Natl.Acad.Sci.Usa 2005 102 13105 13110 1U35 16107708 Crystal structure of the nucleosome core particle containing the histone domain of macroH2A 2004-07-20 2005-09-27 Chakravarthy, S.,Gundimella, S.K.,Caron, C.,Perche, P.Y.,Pehrson, J.R.,Khochbin, S.,Luger, K. Structural characterization of the histone variant macroH2A. Mol.Cell.Biol. 2005 25 7616 7624 1T9T 16166543 Structural Basis of Multidrug transport by the AcrB Multidrug Efflux Pump 2004-05-18 2005-10-04 Yu, E.W.,Aires, J.R.,McDermott, G.,Nikaido, H. A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study J.Bacteriol. 2005 187 6804 6815 1T9U 16166543 Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump 2004-05-18 2005-10-04 Yu, E.W.,Aires, J.R.,McDermott, G.,Nikaido, H. 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Proc.Natl.Acad.Sci.Usa 2005 102 16626 16631 1Y2M 16006165 Crystal structure of phenylalanine ammonia-lyase from yeast Rhododporidium toruloides 2004-11-22 2005-11-01 Wang, L.,Gamez, A.,Sarkissian, C.N.,Straub, M.,Patch, M.G.,Han, G.W.,Striepeke, S.,Fitzpatrick, P.,Scriver, C.R.,Stevens, R.C. Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria. Mol.Genet.Metab. 2005 86 134 140 2B8M Crystal structure of a rmlc-like cupin family protein with a double-stranded beta-helix fold (mj0764) from methanocaldococcus jannaschii at 1.70 A resolution 2005-10-07 2005-11-01 Joint Center for Structural Genomics (JCSG) Crystal structure of (1499583) from METHANOCOCCUS JANNASCHII at 1.70 A resolution To be published 0 0 0 0 2ETD Crystal structure of a lema protein (tm0961) from thermotoga maritima msb8 at 2.28 A resolution 2005-10-27 2005-11-15 Joint Center for Structural Genomics (JCSG) Crystal structure of LEMA protein (tm0961) from THERMOTOGA MARITIMA at 2.28 A resolution To be published 0 0 0 0 2B3H 16274222 Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site 2005-09-20 2005-11-22 Addlagatta, A.,Hu, X.,Liu, J.O.,Matthews, B.W. Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,). Biochemistry 2005 44 14741 14749 2B51 16281058 Structural Basis for UTP Specificity of RNA Editing TUTases from Trypanosoma Brucei 2005-09-27 2005-11-22 Deng, J.,Ernst, N.L.,Turley, S.,Stuart, K.D.,Hol, W.G. Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei. Embo J. 2005 24 4007 4017 2B56 16281058 Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma Brucei 2005-09-27 2005-11-22 Deng, J.,Ernst, N.L.,Turley, S.,Stuart, K.D.,Hol, W.G. Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei. Embo J. 2005 24 4007 4017 2F2T 17004709 Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.7 A resolution with 5-Aminoisoquinoline bound 2005-11-17 2005-11-22 Bosch, J.,Robien, M.A.,Mehlin, C.,Boni, E.,Riechers, A.,Buckner, F.S.,Van Voorhis, W.C.,Myler, P.J.,Worthey, E.A.,DeTitta, G.,Luft, J.R.,Lauricella, A.,Gulde, S.,Anderson, L.A.,Kalyuzhniy, O.,Neely, H.M.,Ross, J.,Earnest, T.N.,Soltis, M.,Schoenfeld, L.,Zucker, F.,Merritt, E.A.,Fan, E.,Verlinde, C.L.,Hol, W.G.J. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem. 2006 49 5939 5946 1ZX4 16306995 Structure of ParB bound to DNA 2005-06-06 2005-11-29 Schumacher, M.A.,Funnell, B.E. Structures of ParB bound to DNA reveal mechanism of partition complex formation. Nature 2005 438 516 519 1ZZS 16285725 Bovine eNOS N368D single mutant with L-N(omega)-Nitroarginine-(4R)-Amino-L-Proline Amide Bound 2005-06-14 2005-12-06 Li, H.,Flinspach, M.L.,Igarashi, J.,Jamal, J.,Yang, W.,Litzinger, E.A.,Huang, H.,Erdal, E.P.,Silverman, R.B.,Poulos, T.L. Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases. Biochemistry 2005 44 15222 15229 2F62 17004709 Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.5 A resolution with (2-ETHYLPHENYL)METHANOL bound 2005-11-28 2005-12-06 Bosch, J.,Robien, M.A.,Mehlin, C.,Boni, E.,Riechers, A.,Buckner, F.S.,Van Voorhis, W.C.,Myler, P.J.,Worthey, E.A.,DeTitta, G.,Luft, J.R.,Lauricella, A.,Gulde, S.,Anderson, L.A.,Kalyuzhniy, O.,Neely, H.M.,Ross, J.,Earnest, T.N.,Soltis, M.,Schoenfeld, L.,Zucker, F.,Merritt, E.A.,Fan, E.,Verlinde, C.L.,Hol, W.G.J. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem. 2006 49 5939 5946 2F67 17004709 Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.6 A resolution with BENZO[CD]INDOL-2(1H)-ONE bound 2005-11-28 2005-12-06 Bosch, J.,Robien, M.A.,Mehlin, C.,Boni, E.,Riechers, A.,Buckner, F.S.,Van Voorhis, W.C.,Myler, P.J.,Worthey, E.A.,DeTitta, G.,Luft, J.R.,Lauricella, A.,Gulde, S.,Anderson, L.A.,Kalyuzhniy, O.,Neely, H.M.,Ross, J.,Earnest, T.N.,Soltis, M.,Schoenfeld, L.,Zucker, F.,Merritt, E.A.,Fan, E.,Verlinde, C.L.,Hol, W.G.J. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem. 2006 49 5939 5946 2AVU 16337229 Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription 2005-08-30 2005-12-13 Wang, S.,Fleming, R.T.,Westbrook, E.M.,Matsumura, P.,McKay, D.B. Structure of the Escherichia coli FlhDC Complex, a Prokaryotic Heteromeric Regulator of Transcription. J.Mol.Biol. 2006 355 798 808 2BDW 16325579 Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II 2005-10-20 2005-12-13 Rosenberg, O.S.,Deindl, S.,Sung, R.-J.,Nairn, A.C.,Kuriyan, J. Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme Cell(Cambridge,Mass.) 2005 123 849 860 2FBW 16371358 Avian respiratory complex II with carboxin bound 2005-12-10 2005-12-20 Huang, L.S.,Sun, G.,Cobessi, D.,Wang, A.C.,Shen, J.T.,Tung, E.Y.,Anderson, V.E.,Berry, E.A. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 2006 281 5965 5972 2AUC 16547135 Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor 2005-08-27 2006-01-17 Bosch, J.,Turley, S.,Daly, T.M.,Bogh, S.M.,Villasmil, M.L.,Roach, C.,Zhou, N.,Morrisey, J.M.,Vaidya, A.B.,Bergman, L.W.,Hol, W.G. Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor. Proc.Natl.Acad.Sci.Usa 2006 103 4852 4857 2FGY 16407248 Beta Carbonic Anhydrase from the Carboxysomal Shell of Halothiobacillus neapolitanus (CsoSCA) 2005-12-22 2006-01-17 Sawaya, M.R.,Cannon, G.C.,Heinhorst, S.,Tanaka, S.,Williams, E.B.,Yeates, T.O.,Kerfeld, C.A. The Structure of beta-carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two. J.Biol.Chem. 2006 281 7546 7555 1ZLJ 16246368 Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain 2005-05-06 2006-01-31 Wisedchaisri, G.,Wu, M.,Rice, A.E.,Roberts, D.M.,Sherman, D.R.,Hol, W.G.J. Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. J.Mol.Biol. 2005 354 630 641 2ANV 16421448 crystal structure of P22 lysozyme mutant L86M 2005-08-11 2006-02-07 Mooers, B.H.,Matthews, B.W. Extension to 2268 atoms of direct methods in the ab initio determination of the unknown structure of bacteriophage P22 lysozyme. Acta Crystallogr.,Sect.D 2006 62 165 176 2ANX 16421448 crystal structure of bacteriophage P22 lysozyme mutant L87M 2005-08-11 2006-02-07 Mooers, B.H.,Matthews, B.W. Extension to 2268 atoms of direct methods in the ab initio determination of the unknown structure of bacteriophage P22 lysozyme. Acta Crystallogr.,Sect.D 2006 62 165 176 2F3N 16439662 Crystal Structure of the native Shank SAM domain. 2005-11-22 2006-02-07 Baron, M.K.,Boeckers, T.M.,Vaida, B.,Faham, S.,Gingery, M.,Sawaya, M.R.,Salyer, D.,Gundelfinger, E.D.,Bowie, J.U. An architectural framework that may lie at the core of the postsynaptic density. Science 2006 311 531 535 2F44 16439662 Crystal Structure of the Zinc-bound Shank SAM domain 2005-11-22 2006-02-07 Baron, M.K.,Boeckers, T.M.,Vaida, B.,Faham, S.,Gingery, M.,Sawaya, M.R.,Salyer, D.,Gundelfinger, E.D.,Bowie, J.U. An architectural framework that may lie at the core of the postsynaptic density. Science 2006 311 531 535 2F86 16441656 The Association Domain of C. elegans CaMKII 2005-12-01 2006-02-07 Rosenberg, O.S.,Deindl, S.,Comolli, L.R.,Hoelz, A.,Downing, K.H.,Nairn, A.C.,Kuriyan, J. Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. Febs J. 2006 273 682 694 2FTZ Crystal structure of Geranyltranstransferase (EC 2.5.1.10) (tm0161) from THERMOTOGA MARITIMA at 1.90 A resolution 2006-01-25 2006-02-07 Joint Center for Structural Genomics (JCSG) Crystal structure of Geranyltranstransferase (EC 2.5.1.10) (tm0161) from THERMOTOGA MARITIMA at 1.90 A resolution To be published 0 0 0 0 2AK1 16472740 Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with benzoic acid 2005-08-02 2006-02-14 Zhu, X.,Dickerson, T.J.,Rogers, C.J.,Kaufmann, G.F.,Mee, J.M.,McKenzie, K.M.,Janda, K.D.,Wilson, I.A. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure 2006 14 205 216 2F2H 16478160 Structure of the YicI thiosugar Michaelis complex 2005-11-16 2006-02-28 Kim, Y.-W.,Lovering, A.L.,Chen, H.,Kantner, T.,McIntosh, L.P.,Strynadka, N.C.J.,Withers, S.G. Expanding the Thioglycoligase Strategy to the Synthesis of alpha-linked Thioglycosides Allows Structural Investigation of the Parent Enzyme/Substrate Complex J.Am.Chem.Soc. 2006 128 2202 2203 2FUP Crystal structure of a putative flagella synthesis protein flgn (pa3352) from pseudomonas aeruginosa at 1.48 A resolution 2006-01-27 2006-02-28 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (NP_252042.1) from Pseudomonas aeruginosa at 1.48 A resolution To be published 0 0 0 0 2FUR CRYSTAL STRUCTURE OF A PUTATIVE FMN-BINDING PROTEIN (TA1372) FROM THERMOPLASMA ACIDOPHILUM AT 1.80 A RESOLUTION 2006-01-27 2006-02-28 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein 10640715 from Thermoplasma acidophilum at 1.80 A resolution To be published 0 0 0 0 2BA2 16522803 Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae 2005-10-13 2006-03-07 Shin, D.H.,Kim, J.-S.,Yokota, H.,Kim, R.,Kim, S.-H. Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae. Protein Sci. 2006 15 921 928 2G0W CRYSTAL STRUCTURE OF A PUTATIVE SUGAR ISOMERASE (LMO2234) FROM LISTERIA MONOCYTOGENES AT 1.70 A RESOLUTION 2006-02-13 2006-03-07 Joint Center for Structural Genomics (JCSG) Crystal structure of Lmo2234 protein (16411704) from Listeria monocytogenes LI2 at 1.70 A resolution To be published 0 0 0 0 2G38 16690741 A PE/PPE Protein Complex from Mycobacterium tuberculosis 2006-02-17 2006-03-14 Strong, M.,Sawaya, M.R.,Wang, S.,Phillips, M.,Cascio, D.,Eisenberg, D. Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.Usa 2006 103 8060 8065 2G38 16690741 A PE/PPE Protein Complex from Mycobacterium tuberculosis 2006-02-17 2006-03-14 Strong, M.,Sawaya, M.R.,Wang, S.,Phillips, M.,Cascio, D.,Eisenberg, D. Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.Usa 2006 103 8060 8065 2FO0 16543148 Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase 2006-01-12 2006-03-21 Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J. Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol.Cell 2006 21 787 798 2FZT CRYSTAL STRUCTURE OF a putative nucleic acid binding protein (TM0693) FROM THERMOTOGA MARITIMA MSB8 AT 2.05 A RESOLUTION 2006-02-10 2006-03-21 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (tm0693) from THERMOTOGA MARITIMA at 2.05 A resolution To be published 0 0 0 0 2G8L Crystal structure of a duf89 family protein (ph1575) from pyrococcus horikoshii at 2.04 A resolution 2006-03-02 2006-03-21 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (3258004) from Pyrococcus horikoshii at 2.04 A resolution To be published 0 0 0 0 2ESS Crystal structure of an acyl-ACP thioesterase (NP_810988.1) from Bacteroides thetaiotaomicron VPI-5482 at 1.90 A resolution 2005-10-26 2006-03-28 Joint Center for Structural Genomics (JCSG) Crystal structure of an acyl-ACP thioesterase (NP_810988.1) from Bacteroides thetaiotaomicron VPI-5482 at 1.90 A resolution To be published 0 0 0 0 2G36 20944229 Crystal structure of Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan-tRNA ligase)(TrpRS) (tm0492) from THERMOTOGA MARITIMA at 2.50 A resolution 2006-02-17 2006-03-28 Han, G.W.,Yang, X.L.,McMullan, D.,Chong, Y.E.,Krishna, S.S.,Rife, C.L.,Weekes, D.,Brittain, S.M.,Abdubek, P.,Ambing, E.,Astakhova, T.,Axelrod, H.L.,Carlton, D.,Caruthers, J.,Chiu, H.J.,Clayton, T.,Duan, L.,Feuerhelm, J.,Grant, J.C.,Grzechnik, S.K.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kumar, A.,Marciano, D.,Miller, M.D.,Morse, A.T.,Nigoghossian, E.,Okach, L.,Paulsen, J.,Reyes, R.,van den Bedem, H.,White, A.,Wolf, G.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Elsliger, M.A.,Schimmel, P.,Wilson, I.A. Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster. Acta Crystallogr.,Sect.F 2010 66 1326 1334 2GB5 Crystal structure of NADH pyrophosphatase (EC 3.6.1.22) (1790429) from Escherichia coli K12 at 2.30 A resolution 2006-03-09 2006-03-28 Joint Center for Structural Genomics (JCSG) Crystal structure of NADH pyrophosphatase (EC 3.6.1.22) (1790429) from Escherichia coli K12 at 2.30 A resolution To be published 0 0 0 0 2B4H 16511559 Crystal Structure of the Rhesus Rotavirus VP5 Antigen Domain Dimer 2005-09-24 2006-04-18 Yoder, J.D.,Dormitzer, P.R. Alternative intermolecular contacts underlie the rotavirus VP5(*) two- to three-fold rearrangement Embo J. 2006 25 1559 1568 2B4I 16511559 Crystal Structure of the Rhesus Rotavirus VP5 Antigen Domain Trimer 2005-09-24 2006-04-18 Yoder, J.D.,Dormitzer, P.R. Alternative intermolecular contacts underlie the rotavirus VP5(*) two- to three-fold rearrangement Embo J. 2006 25 1559 1568 2F32 16600969 Xray crystal structure of lysozyme mutant L20/R63A liganded to ethylguanidinium 2005-11-18 2006-04-25 Yousef, M.S.,Bischoff, N.,Dyer, C.M.,Baase, W.A.,Matthews, B.W. Guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme. Protein Sci. 2006 15 853 861 2F47 16600969 Xray crystal structure of T4 lysozyme mutant L20/R63A liganded to methylguanidinium 2005-11-22 2006-04-25 Yousef, M.S.,Bischoff, N.,Dyer, C.M.,Baase, W.A.,Matthews, B.W. Guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme. Protein Sci. 2006 15 853 861 2FK0 16543414 Crystal Structure of a H5N1 influenza virus hemagglutinin. 2006-01-03 2006-05-02 Stevens, J.,Blixt, O.,Tumpey, T.M.,Taubenberger, J.K.,Paulson, J.C.,Wilson, I.A. Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus. Science 2006 312 404 410 2GEW 16604066 Atomic resolution structure of cholesterol oxidase @ pH 9.0 (Streptomyces sp. SA-COO) 2006-03-20 2006-05-02 Lyubimov, A.Y.,Lario, P.I.,Moustafa, I.,Vrielink, A. Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment. Nat.Chem.Biol. 2006 2 259 264 2GFG Crystal structure of a putative adenylate cyclase (bh2851) from bacillus halodurans at 2.12 A resolution 2006-03-21 2006-05-02 Joint Center for Structural Genomics (JCSG) Crystal structure of the protein BH2851 (10175472) from Bacillus halodurans at 2.12 A resolution To be published 0 0 0 0 2G2H 16640460 A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain 2006-02-16 2006-05-23 Levinson, N.M.,Kuchment, O.,Shen, K.,Young, M.A.,Koldobskiy, M.,Karplus, M.,Cole, P.A.,Kuriyan, J. A SRC-like inactive conformation in the abl tyrosine kinase domain. 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J.Mol.Biol. 2007 373 1006 1016 2RH6 Structure of Xac NPP for evaluation of refinement methodology 2007-10-06 2007-10-30 Fenn, T.D.,Pozharski, E.,Wilson, M.A. Crystallographic Goodness of Fit: A New Treatment of Model Complexity To be Published 0 0 0 0 2RLD CRYSTAL STRUCTURE OF A PROTEIN WITH UNKNOWN FUNCTION FROM S23 RIBOSOMAL PROTEIN FAMILY (BT_0352) FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 AT 1.70 A RESOLUTION 2007-10-18 2007-10-30 Joint Center for Structural Genomics (JCSG) Crystal structure of uncharacterized protein (NP_809265.1) from Bacteroides thetaiotaomicron VPI-5482 at 1.70 A resolution To be published 0 0 0 0 3B77 19913036 Crystal structure of a ph domain containing bacterial protein (exig_2160) from exiguobacterium sibiricum 255-15 at 2.42 A resolution 2007-10-30 2007-11-13 Xu, Q.,Bateman, A.,Finn, R.D.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Bakolitsa, C.,Carlton, D.,Chen, C.,Chiu, H.J.,Chiu, M.,Clayton, T.,Das, D.,Deller, M.C.,Duan, L.,Ellrott, K.,Ernst, D.,Farr, C.L.,Feuerhelm, J.,Grant, J.C.,Grzechnik, A.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Krishna, S.S.,Kumar, A.,Marciano, D.,McMullan, D.,Miller, M.D.,Morse, A.T.,Nigoghossian, E.,Nopakun, A.,Okach, L.,Puckett, C.,Reyes, R.,Rife, C.L.,Sefcovic, N.,Tien, H.J.,Trame, C.B.,van den Bedem, H.,Weekes, D.,Wooten, T.,Hodgson, K.O.,Wooley, J.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A. Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain. J.Mol.Biol. 2010 396 31 46 3B7C CRYSTAL STRUCTURE OF A NTF-2 LIKE PROTEIN OF UNKNOWN FUNCTION (SO_0125) FROM SHEWANELLA ONEIDENSIS MR-1 AT 1.70 A RESOLUTION 2007-10-30 2007-11-13 Joint Center for Structural Genomics (JCSG) Crystal structure of NTF-2 like protein of unknown function (NP_715767.1) from Shewanella oneidensis at 1.70 A resolution To be published 0 0 0 0 3B7F Crystal structure of a putative glycosyl hydrolase with bnr repeats (reut_b4987) from ralstonia eutropha jmp134 at 2.20 A resolution 2007-10-30 2007-11-13 Joint Center for Structural Genomics (JCSG) Crystal structure of Domain of Unknown Function with a 7-Bladed Beta-Propeller Fold (YP_299179.1) from Ralstonia eutropha JMP134 at 2.20 A resolution To be published 0 0 0 0 2RKC Crystal structure of the measles virus hemagglutinin 2007-10-16 2007-11-20 Colf, L.A.,Juo, Z.S.,Garcia, K.C. Structure of the measles virus hemagglutinin: implications for host cell receptor attachment. To be Published 0 0 0 0 3B81 Crystal structure of predicted DNA-binding transcriptional regulator of TetR/AcrR family (NP_350189.1) from Clostridium acetobutylicum at 2.10 A resolution 2007-10-31 2007-11-20 Joint Center for Structural Genomics (JCSG) Crystal structure of predicted DNA-binding transcriptional regulator of TetR/AcrR family (NP_350189.1) from Clostridium acetobutylicum at 2.10 A resolution To be published 0 0 0 0 3B9T Crystal structure of predicted acetamidase/formamidase (YP_546212.1) from Methylobacillus flagellatus KT at 1.58 A resolution 2007-11-06 2007-11-20 Joint Center for Structural Genomics (JCSG) Crystal structure of predicted acetamidase/formamidase (YP_546212.1) from Methylobacillus flagellatus KT at 1.58 A resolution To be published 0 0 0 0 3BB5 CRYSTAL STRUCTURE OF A DIMERIC FERREDOXIN-LIKE PROTEIN OF UNKNOWN FUNCTION (JANN_3925) FROM JANNASCHIA SP. CCS1 AT 2.30 A RESOLUTION 2007-11-09 2007-11-20 Joint Center for Structural Genomics (JCSG) Crystal structure of dimeric ferredoxin-like protein of unknown function (YP_511867.1) from Jannaschia sp. CCS1 at 2.30 A resolution To be published 0 0 0 0 3BB9 Crystal structure of a putative ketosteroid isomerase (sfri_1973) from shewanella frigidimarina ncimb 400 at 1.80 A resolution 2007-11-09 2007-11-20 Joint Center for Structural Genomics (JCSG) Crystal structure of putative ketosteroid isomerase (YP_750657.1) from Shewanella frigidimarina NCIMB 400 at 1.80 A resolution To be published 0 0 0 0 3B8L CRYSTAL STRUCTURE OF A PUTATIVE AROMATIC RING HYDROXYLASE (SARO_3538) FROM NOVOSPHINGOBIUM AROMATICIVORANS DSM AT 1.75 A RESOLUTION 2007-11-01 2007-11-27 Joint Center for Structural Genomics (JCSG) Crystal structure of NTF2-like protein of unknown function (YP_001165924.1) from Novosphingobium aromaticivorans DSM 12444 at 1.75 A resolution To be published 0 0 0 0 3BDE Crystal structure of a dabb family protein with a ferredoxin-like fold (mll5499) from mesorhizobium loti maff303099 at 1.79 A resolution 2007-11-14 2007-11-27 Joint Center for Structural Genomics (JCSG) Crystal structure of domain of unknown function with a ferredoxin-like fold (NP_106155.1) from Mesorhizobium loti at 1.79 A resolution To be published 0 0 0 0 2QZV 18044992 Draft Crystal Structure of the Vault Shell at 9 Angstroms Resolution 2007-08-17 2007-12-04 Anderson, D.H.,Kickhoefer, V.A.,Sievers, S.A.,Rome, L.H.,Eisenberg, D. 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Structure 2007 15 1392 1402 3B4A 17990888 T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate 2007-10-23 2007-12-11 Klein, D.J.,Been, M.D.,Ferre-D'Amare, A.R. Essential Role of an Active-Site Guanine in glmS Ribozyme Catalysis. J.Am.Chem.Soc. 2007 129 14858 14859 3BGU Crystal structure of a dimeric ferredoxin-like protein of unknown function (tfu_0763) from thermobifida fusca yx at 1.50 A resolution 2007-11-27 2007-12-11 Joint Center for Structural Genomics (JCSG) Crystal structure of dimeric ferredoxin-like protein of unknown function (YP_288824.1) from Thermobifida fusca YX at 1.50 A resolution To be published 0 0 0 0 3BHN Crystal structure of a dj-1/pfpi-like protein (shew_2856) from shewanella loihica pv-4 at 1.76 A resolution 2007-11-28 2007-12-11 Joint Center for Structural Genomics (JCSG) Crystal structure of DJ-1 like Protein (YP_001094981.1) from Shewanella loihica PV-4 at 1.76 A resolution To be published 0 0 0 0 3BIW 18093522 Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex 2007-12-01 2007-12-18 Arac, D.,Boucard, A.A.,Ozkan, E.,Strop, P.,Newell, E.,Sudhof, T.C.,Brunger, A.T. 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Nature 2008 453 124 127 3C00 18451864 Crystal structural of the mutated G247T EscU/SpaS C-terminal domain 2008-01-18 2008-04-22 Zarivach, R.,Deng, W.,Vuckovic, M.,Felise, H.B.,Nguyen, H.V.,Miller, S.I.,Finlay, B.B.,Strynadka, N.C. Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature 2008 453 124 127 3C01 18451864 Crystal structural of native SpaS C-terminal domain 2008-01-18 2008-04-22 Zarivach, R.,Deng, W.,Vuckovic, M.,Felise, H.B.,Nguyen, H.V.,Miller, S.I.,Finlay, B.B.,Strynadka, N.C. Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature 2008 453 124 127 3C57 18353359 Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain Crystal Form II 2008-01-30 2008-04-22 Wisedchaisri, G.,Wu, M.,Sherman, D.R.,Hol, W.G. 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Biochemistry 2008 47 5303 5311 3C1O 18208524 The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct lineages 2008-01-23 2008-05-06 Koeduka, T.,Louie, G.V.,Orlova, I.,Kish, C.M.,Ibdah, M.,Wilkerson, C.G.,Bowman, M.E.,Baiga, T.J.,Noel, J.P.,Dudareva, N.,Pichersky, E. The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. Plant J. 2008 54 362 374 3C3X 18208524 The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct lineages 2008-01-29 2008-05-06 Koeduka, T.,Louie, G.V.,Orlova, I.,Kish, C.M.,Ibdah, M.,Wilkerson, C.G.,Bowman, M.E.,Baiga, T.J.,Noel, J.P.,Dudareva, N.,Pichersky, E. The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. 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J.Mol.Biol. 2008 381 1292 1306 3DBH 18652489 Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Ala-NEDD8Ala72Arg) 2008-05-31 2008-08-12 Souphron, J.,Waddell, M.B.,Paydar, A.,Tokgoz-Gromley, Z.,Roussel, M.F.,Schulman, B.A. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry 2008 47 8961 8969 3DBL 18652489 Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190wt-NEDD8Ala72Gln) 2008-06-01 2008-08-12 Souphron, J.,Waddell, M.B.,Paydar, A.,Tokgoz-Gromley, Z.,Roussel, M.F.,Schulman, B.A. Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Biochemistry 2008 47 8961 8969 2VPV 18701705 Dimerization Domain of Mif2p 2008-03-05 2008-08-26 Cohen, R.L.,Espelin, C.W.,De Wulf, P.,Sorger, P.K.,Harrison, S.C.,Simons, K.T. Structural and Functional Dissection of Mif2P, a Conserved DNA-Binding Kinetochore Protein. Mol.Biol.Cell 2008 19 4480 0 2PPP 18704951 Crystal structure of E60Q mutant of FKBP12 2007-04-30 2008-09-02 Szep, S.,Park, S.,Boder, E.T.,Van Duyne, G.D.,Saven, J.G. Structural coupling between FKBP12 and buried water. Proteins 2009 74 603 611 3CGI 18786396 Crystal structure of the PduU shell protein from the Pdu microcompartment 2008-03-05 2008-09-02 Crowley, C.S.,Sawaya, M.R.,Bobik, T.A.,Yeates, T.O. Structure of the PduU Shell Protein from the Pdu Microcompartment of Salmonella Structure 2008 16 1324 1332 3ECQ 18784084 Endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae: SeMet structure 2008-09-01 2008-09-09 Caines, M.E.,Zhu, H.,Vuckovic, M.,Willis, L.M.,Withers, S.G.,Wakarchuk, W.W.,Strynadka, N.C. The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design. J.Biol.Chem. 2008 283 31279 31283 2QEX 17664317 Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit 2007-06-26 2008-09-30 Schroeder, S.J.,Blaha, G.,Moore, P.B. Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit. Antimicrob.Agents Chemother. 2007 51 4462 4465 3DWK 18760285 Identification of Dynamic Structural Motifs Involved in Peptidoglycan Glycosyltransfer 2008-07-22 2008-09-30 Lovering, A.L.,De Castro, L.,Strynadka, N.C. Identification of dynamic structural motifs involved in peptidoglycan glycosyltransfer. J.Mol.Biol. 2008 383 167 177 3DMK 18805093 Crystal structure of Down Syndrome Cell Adhesion Molecule (DSCAM) isoform 1.30.30, N-terminal eight Ig domains 2008-07-01 2008-10-07 Sawaya, M.R.,Wojtowicz, W.M.,Andre, I.,Qian, B.,Wu, W.,Baker, D.,Eisenberg, D.,Zipursky, S.L. A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell(Cambridge,Mass.) 2008 134 1007 1018 3EN7 18849971 Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with S1, a multitargeted kinase inhibitor 2008-09-25 2008-10-14 Apsel, B.,Blair, J.A.,Gonzalez, B.,Nazif, T.M.,Feldman, M.E.,Aizenstein, B.,Hoffman, R.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol. 2008 4 691 699 3ET6 18842118 The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase 2008-10-07 2008-10-14 Winger, J.A.,Derbyshire, E.R.,Lamers, M.H.,Marletta, M.A.,Kuriyan, J. The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. Bmc Struct.Biol. 2008 8 42 42 3DYC 18851975 Structure of E322Y Alkaline Phosphatase in Complex with Inorganic Phosphate 2008-07-25 2008-10-21 Zalatan, J.G.,Fenn, T.D.,Herschlag, D. Comparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active-Site Metal Ion. J.Mol.Biol. 2008 384 1174 1189 3ECH 18812515 The MarR-family repressor MexR in complex with its antirepressor ArmR 2008-08-30 2008-10-21 Wilke, M.S.,Heller, M.,Creagh, A.L.,Haynes, C.A.,McIntosh, L.P.,Poole, K.,Strynadka, N.C.J. The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR Proc.Natl.Acad.Sci.Usa 2008 105 14832 14837 3E2H 18941216 Structure of the m67 high-affinity mutant of the 2C TCR in complex with Ld/QL9 2008-08-05 2008-11-04 Jones, L.L.,Colf, L.A.,Stone, J.D.,Garcia, K.C.,Kranz, D.M. Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation J.Immunol. 2008 181 6255 6264 3F6T Crystal structure of aspartate aminotransferase (E.C. 2.6.1.1) (YP_194538.1) from Lactobacillus acidophilus NCFM at 2.15 A resolution 2008-11-06 2008-12-09 Joint Center for Structural Genomics (JCSG) Crystal structure of aspartate aminotransferase (E.C. 2.6.1.1) (YP_194538.1) from Lactobacillus acidophilus NCFM at 2.15 A resolution To be published 0 0 0 0 3EK4 19098007 Calcium-saturated GCaMP2 Monomer 2008-09-18 2008-12-16 Akerboom, J.,Rivera, J.D.,Guilbe, M.M.,Malave, E.C.,Hernandez, H.H.,Tian, L.,Hires, S.A.,Marvin, J.S.,Looger, L.L.,Schreiter, E.R. Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design J.Biol.Chem. 2009 284 6455 6464 3BQZ Crystal Structure of the Complex of Malachite Green Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor 2007-12-20 2008-12-23 Brooks, B.E.,Hardie, K.M.,Brown, M.H.,Skurray, R.A.,Brennan, R.G. Formal electrostatic interactions do not govern QacR-cation affinity To be Published 0 0 0 0 3BR0 Crystal Structure of the Complex of Malachite Green Bound to QacR(E120Q), a Mutant of a Multidrug Binding Transcriptional Repressor 2007-12-20 2008-12-23 Brooks, B.E.,Hardie, K.M.,Brown, M.H.,Skurray, R.A.,Brennan, R.G. Formal electrostatic interactions do not govern QacR-cation affinity To be Published 0 0 0 0 3F3A 19074341 Crystal Structure of LeuT bound to L-Tryptophan and Sodium 2008-10-30 2008-12-23 Singh, S.K.,Piscitelli, C.L.,Yamashita, A.,Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008 322 1655 1661 3F3C 19074341 Crystal structure of LeuT bound to 4-Fluoro-L-Phenylalanine and sodium 2008-10-30 2008-12-23 Singh, S.K.,Piscitelli, C.L.,Yamashita, A.,Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008 322 1655 1661 3F3D 19074341 Crystal structure of LeuT bound to L-Methionine and sodium 2008-10-30 2008-12-23 Singh, S.K.,Piscitelli, C.L.,Yamashita, A.,Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008 322 1655 1661 3F3E 19074341 Crystal structure of LeuT bound to L-leucine (30 mM) and sodium 2008-10-30 2008-12-23 Singh, S.K.,Piscitelli, C.L.,Yamashita, A.,Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008 322 1655 1661 3F4I 19074341 Crystal Structure of LeuT bound to L-selenomethionine and sodium 2008-10-31 2008-12-23 Singh, S.K.,Piscitelli, C.L.,Yamashita, A.,Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008 322 1655 1661 3F4J 19074341 Crystal structure of LeuT bound to glycine and sodium 2008-10-31 2008-12-23 Singh, S.K.,Piscitelli, C.L.,Yamashita, A.,Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008 322 1655 1661 3DN9 19177356 Carboxysome Subunit, CcmK1 C-terminal deletion mutant 2008-07-01 2009-01-20 Tanaka, S.,Sawaya, M.R.,Phillips, M.,Yeates, T.O. Insights from multiple structures of the shell proteins from the beta-carboxysome. Protein Sci. 2009 18 108 120 3CIM 19177356 Carboxysome shell protein, CcmK2 C-terminal deletion mutant 2008-03-11 2009-02-03 Tanaka, S.,Sawaya, M.R.,Phillips, M.,Yeates, T.O. Insights from multiple structures of the shell proteins from the beta-carboxysome. Protein Sci. 2009 18 108 120 2ZI8 19300498 Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis in complex with 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (DHSA) 2008-02-13 2009-02-24 Yam, K.C.,D'Angelo, I.,Kalscheuer, R.,Zhu, H.,Wang, J.X.,Snieckus, V.,Ly, L.H.,Converse, P.J.,Jacobs, W.R.,Strynadka, N.,Eltis, L.D. Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. Plos Pathog. 2009 5 0 0 3GET Crystal structure of putative histidinol-phosphate aminotransferase (NP_281508.1) from Campylobacter jejuni at 2.01 A resolution 2009-02-26 2009-03-24 Joint Center for Structural Genomics (JCSG) Crystal structure of putative histidinol-phosphate aminotransferase (NP_281508.1) from Campylobacter jejuni at 2.01 A resolution To be published 0 0 0 0 3GMY 19332077 Crystal Structure of Beta-Lactamse Inhibitory Protein-Like Protein (BLP), Selenomethionine Derivative 2009-03-15 2009-03-31 Gretes, M.,Lim, D.C.,de Castro, L.,Jensen, S.E.,Kang, S.G.,Lee, K.J.,Strynadka, N.C. Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the beta-lactamase inhibitory proteins BLIP, BLIP-I, and BLP. J.Mol.Biol. 2009 389 289 305 3F3F 19111661 Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21 2008-10-30 2009-04-07 Debler, E.W.,Ma, Y.,Seo, H.S.,Hsia, K.C.,Noriega, T.R.,Blobel, G.,Hoelz, A. 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Nat.Struct.Mol.Biol. 2009 16 468 476 3GLF 19450514 Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA 2009-03-12 2009-05-26 Simonetta, K.R.,Kazmirski, S.L.,Goedken, E.R.,Cantor, A.J.,Kelch, B.A.,McNally, R.,Seyedin, S.N.,Makino, D.L.,O'Donnell, M.,Kuriyan, J. The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell(Cambridge,Mass.) 2009 137 659 671 3GLG 19450514 Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA 2009-03-12 2009-05-26 Simonetta, K.R.,Kazmirski, S.L.,Goedken, E.R.,Cantor, A.J.,Kelch, B.A.,McNally, R.,Seyedin, S.N.,Makino, D.L.,O'Donnell, M.,Kuriyan, J. The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. 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Science 2009 325 1010 1014 3GUJ 19663503 T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Benzene binding 2009-03-30 2009-08-25 Liu, L.,Baase, W.A.,Michael, M.M.,Matthews, B.W. Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme. Biochemistry 2009 48 8842 8851 2WN9 19696737 Crystal structure of Aplysia ACHBP in complex with 4-0H-DMXBA 2009-07-07 2009-09-01 Hibbs, R.E.,Sulzenbacher, G.,Shi, J.,Talley, T.T.,Conrod, S.,Kem, W.R.,Taylor, P.,Marchot, P.,Bourne, Y. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. Embo J. 2009 28 3040 3051 3FHK 19653655 Crystal structure of APC1446, B.subtilis YphP disulfide isomerase 2008-12-09 2009-09-01 Derewenda, U.,Boczek, T.,Gorres, K.L.,Yu, M.,Hung, L.W.,Cooper, D.,Joachimiak, A.,Raines, R.T.,Derewenda, Z.S. Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif . Biochemistry 2009 48 8664 8671 3IIQ 19655811 Crystallographic analysis of bacterial signal peptidase in ternary complex with Arylomycin A2 and a beta-sultam inhibitor 2009-08-03 2009-09-01 Luo, C.,Roussel, P.,Dreier, J.,Page, M.G.,Paetzel, M. Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a Beta-Sultam Inhibitor. Biochemistry 2009 48 8976 0 3GUT 19683540 Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR 2009-03-30 2009-09-08 Stroud, J.C.,Oltman, A.,Han, A.,Bates, D.L.,Chen, L. Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR. 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Science 2011 334 1675 1680 3US5 Crystal structure of a RNA-binding domain of a poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 1.38 A resolution 2011-11-23 2012-01-11 Joint Center for Structural Genomics (JCSG),Partnership for T-Cell Biology Crystal structure of a RNA-binding domain of a poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 1.38 A resolution To be published 0 0 0 0 3UWT Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution 2011-12-02 2012-01-11 Joint Center for Structural Genomics (JCSG),Partnership for T-Cell Biology (TCELL) Crystal structure of a RNA binding domain of poly-U binding splicing factor 60KDa (PUF60) from Homo sapiens at 2.50 A resolution To be published 0 0 0 0 3QLI 21966419 Crystal Structure of RipA from Yersinia pestis 2011-02-02 2012-01-18 Torres, R.,Swift, R.V.,Chim, N.,Wheatley, N.,Lan, B.,Atwood, B.R.,Pujol, C.,Sankaran, B.,Bliska, J.B.,Amaro, R.E.,Goulding, C.W. Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. Plos One 2011 6 0 0 3QLK 21966419 Crystal Structure of RipA from Yersinia pestis 2011-02-02 2012-01-18 Torres, R.,Swift, R.V.,Chim, N.,Wheatley, N.,Lan, B.,Atwood, B.R.,Pujol, C.,Sankaran, B.,Bliska, J.B.,Amaro, R.E.,Goulding, C.W. Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. Plos One 2011 6 0 0 3S8D 21966419 Crystal Structure of RipA from Yersinia pestis 2011-05-27 2012-01-18 Torres, R.,Swift, R.V.,Chim, N.,Wheatley, N.,Lan, B.,Atwood, B.R.,Pujol, C.,Sankaran, B.,Bliska, J.B.,Amaro, R.E.,Goulding, C.W. Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. Plos One 2011 6 0 0 3UTM 22307604 Crystal structure of a mouse Tankyrase-Axin complex 2011-11-26 2012-01-18 Morrone, S.,Cheng, Z.,Moon, R.T.,Cong, F.,Xu, W. 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H240A variant of human ferrochelatase To be published 0 0 0 0 3UP9 Crystal structure of a putative lipoprotein (ACTODO_00931) from Actinomyces odontolyticus ATCC 17982 at 2.35 A resolution 2011-11-17 2012-01-25 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein ACTODO_00931 (hypothetical protein ACTODO_00931, SP17422A, P_02044074.1) from Actinomyces odontolyticus ATCC 17982 at 2.35 A resolution To be published 0 0 0 0 4D8K Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution 2012-01-10 2012-01-25 Joint Center for Structural Genomics (JCSG),Partnership for T-Cell Biology Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution To be published 0 0 0 0 3R4Z 21810409 Crystal structure of alpha-neoagarobiose hydrolase (ALPHA-NABH) in complex with alpha-d-galactopyranose from Saccharophagus degradans 2-40 2011-03-18 2012-02-01 Ha, S.C.,Lee, S.,Lee, J.,Kim, H.T.,Ko, H.J.,Kim, K.H.,Choi, I.G. Crystal structure of a key enzyme in the agarolytic pathway, alpha-neoagarobiose hydrolase from Saccharophagus degradans 2-40 Biochem.Biophys.Res.Commun. 2011 412 238 244 3TNP 22323819 Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme 2011-09-01 2012-02-01 Zhang, P.,Smith-Nguyen, E.V.,Keshwani, M.M.,Deal, M.S.,Kornev, A.P.,Taylor, S.S. Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science 2012 335 712 716 3TNQ 22323819 Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme 2011-09-01 2012-02-01 Zhang, P.,Smith-Nguyen, E.V.,Keshwani, M.M.,Deal, M.S.,Kornev, A.P.,Taylor, S.S. Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science 2012 335 712 716 3UTF 22294687 Crystal structure of Aspergillus fumigatus UDP galactopyranose mutase in reduced state 2011-11-25 2012-02-08 Dhatwalia, R.,Singh, H.,Oppenheimer, M.,Karr, D.B.,Nix, J.C.,Sobrado, P.,Tanner, J.J. Crystal Structures and Small-angle X-ray Scattering Analysis of UDP-galactopyranose Mutase from the Pathogenic Fungus Aspergillus fumigatus. J.Biol.Chem. 2012 287 9041 9051 3UTG 22294687 Crystal structure of Aspergillus fumigatus UDP galactopyranose mutase complexed with UDP in reduced state 2011-11-25 2012-02-08 Dhatwalia, R.,Singh, H.,Oppenheimer, M.,Karr, D.B.,Nix, J.C.,Sobrado, P.,Tanner, J.J. Crystal Structures and Small-angle X-ray Scattering Analysis of UDP-galactopyranose Mutase from the Pathogenic Fungus Aspergillus fumigatus. J.Biol.Chem. 2012 287 9041 9051 4DFY 22334660 Crystal structure of R194A mutant of cAMP-dependent protein kinase with unphosphorylated activation loop 2012-01-24 2012-02-15 Steichen, J.M.,Kuchinskas, M.,Keshwani, M.M.,Yang, J.,Adams, J.A.,Taylor, S.S. Structural basis for the regulation of protein kinase a by activation loop phosphorylation. J.Biol.Chem. 2012 287 14672 14680 3TRP 22337878 Crystal structure of recombinant rabbit skeletal calsequestrin 2011-09-09 2012-02-22 Sanchez, E.J.,Lewis, K.M.,Danna, B.R.,Kang, C. High-capacity Ca2+ Binding of Human Skeletal Calsequestrin. J.Biol.Chem. 2012 287 11592 11601 3UOM 22337878 Ca2+ complex of Human skeletal calsequestrin 2011-11-16 2012-02-22 Sanchez, E.J.,Lewis, K.M.,Danna, B.R.,Kang, C. High-capacity Ca2+ Binding of Human Skeletal Calsequestrin. J.Biol.Chem. 2012 287 11592 11601 4DNL Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at 1.90 A resolution 2012-02-08 2012-02-22 Joint Center for Structural Genomics (JCSG),Partnership for T-Cell Biology (TCELL) Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at 1.90 A resolution To be published 0 0 0 0 4DS2 Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi 2012-02-17 2012-02-29 Merritt, E.A.,Arakaki, T.,Napuli, A.,Van Voorhis, W.C.,Buckner, F.S.,Fan, E.,Zucker, F.,Verlinde, L.M.J.,Kim, J.,Hol, W.G.J. Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi To be Published 0 0 0 0 3TYJ 22405006 Bacillus collagen-like protein of anthracis P159S mutant 2011-09-26 2012-03-14 Kirchdoerfer, R.N.,Herrin, B.R.,Han, B.W.,Turnbough, C.L.,Cooper, M.D.,Wilson, I.A. Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores. Structure 2012 20 479 486 4DJF 22419154 Crystal structure of folate-bound corrinoid iron-sulfur protein (CFeSP) in complex with its methyltransferase (MeTr), co-crystallized with folate and Ti(III) citrate reductant 2012-02-01 2012-03-14 Kung, Y.,Ando, N.,Doukov, T.I.,Blasiak, L.C.,Bender, G.,Seravalli, J.,Ragsdale, S.W.,Drennan, C.L. Visualizing molecular juggling within a B12-dependent methyltransferase complex. Nature 2012 484 265 269 3RQ9 22511866 Structure of Tsi2, a Tse2-immunity protein from Pseudomonas aeruginosa 2011-04-27 2012-03-21 Li, M.,Le Trong, I.,Carl, M.A.,Larson, E.T.,Chou, S.,De Leon, J.A.,Dove, S.L.,Stenkamp, R.E.,Mougous, J.D. Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein. Plos Pathog. 2012 8 0 0 3SGM 22403391 Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100 2011-06-15 2012-03-21 Laganowsky, A.,Liu, C.,Sawaya, M.R.,Whitelegge, J.P.,Park, J.,Zhao, M.,Pensalfini, A.,Soriaga, A.B.,Landau, M.,Teng, P.K.,Cascio, D.,Glabe, C.,Eisenberg, D. Atomic view of a toxic amyloid small oligomer. Science 2012 335 1228 1231 3SGM 22403391 Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100 2011-06-15 2012-03-21 Laganowsky, A.,Liu, C.,Sawaya, M.R.,Whitelegge, J.P.,Park, J.,Zhao, M.,Pensalfini, A.,Soriaga, A.B.,Landau, M.,Teng, P.K.,Cascio, D.,Glabe, C.,Eisenberg, D. Atomic view of a toxic amyloid small oligomer. Science 2012 335 1228 1231 4DBM 22394239 Aplysia californica-AChBP in complex with triazole 18 2012-01-16 2012-03-21 Grimster, N.P.,Stump, B.,Fotsing, J.R.,Weide, T.,Talley, T.T.,Yamauchi, J.G.,Nemecz, A.,Kim, C.,Ho, K.Y.,Sharpless, K.B.,Taylor, P.,Fokin, V.V. Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template. J.Am.Chem.Soc. 2012 134 6732 6740 3TL1 22432862 Crystal structure of the Streptomyces coelicolor WhiE ORFVI polyketide aromatase/cyclase 2011-08-29 2012-04-04 Lee, M.Y.,Ames, B.D.,Tsai, S.C. Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI. Biochemistry 2012 51 3079 3091 3QAZ 22446627 IL-2 mutant D10 ternary complex 2011-01-12 2012-04-11 Levin, A.M.,Bates, D.L.,Ring, A.M.,Krieg, C.,Lin, J.T.,Su, L.,Moraga, I.,Raeber, M.E.,Bowman, G.R.,Novick, P.,Pande, V.S.,Fathman, C.G.,Boyman, O.,Garcia, K.C. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature 2012 484 529 533 3QB7 23103943 Interleukin-4 mutant RGA bound to cytokine receptor common gamma 2011-01-12 2012-04-25 Junttila, I.S.,Creusot, R.J.,Moraga, I.,Bates, D.L.,Wong, M.T.,Alonso, M.N.,Suhoski, M.M.,Lupardus, P.,Meier-Schellersheim, M.,Engleman, E.G.,Utz, P.J.,Fathman, C.G.,Paul, W.E.,Garcia, K.C. Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nat.Chem.Biol. 2012 8 990 998 3STX 22523203 Crystal Structure of tomato Methylketone Synthase I H243A variant complexed with beta-ketoheptanoate 2011-07-11 2012-05-02 Auldridge, M.E.,Guo, Y.,Austin, M.B.,Ramsey, J.,Fridman, E.,Pichersky, E.,Noel, J.P. Emergent Decarboxylase Activity and Attenuation of alpha/beta-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in Tomato. Plant Cell 2012 24 1596 1607 4DOK 22622584 Crystal structure of Arabidopsis thaliana chalcone-isomerase like protein At5g05270 (AtCHIL) 2012-02-09 2012-05-09 Ngaki, M.N.,Louie, G.V.,Philippe, R.N.,Manning, G.,Pojer, F.,Bowman, M.E.,Li, L.,Larsen, E.,Wurtele, E.S.,Noel, J.P. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature 2012 485 530 533 4DOL 22622584 Crystal structure of Arabidopsis thaliana fatty-acid binding protein At1g53520 (AtFAP3) 2012-02-09 2012-05-09 Ngaki, M.N.,Louie, G.V.,Philippe, R.N.,Manning, G.,Pojer, F.,Bowman, M.E.,Li, L.,Larsen, E.,Wurtele, E.S.,Noel, J.P. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature 2012 485 530 533 3ROR Crystal structure of C105S mutant of Mycobacterium tuberculosis methionine aminopeptidase 2011-04-26 2012-05-23 Reddi, R.,Kishor, C.,Addlagatta, A. Crystal structure of C105S mutant of Mycobacterium tuberculosis methionine aminopeptidase To be Published 0 0 0 0 3URC 22635267 T181G mutant of alpha-Lytic Protease 2011-11-22 2012-05-23 Kelch, B.A.,Salimi, N.L.,Agard, D.A. Functional modulation of a protein folding landscape via side-chain distortion. Proc.Natl.Acad.Sci.USA 2012 109 9414 9419 3URD 22635267 T181A mutant of alpha-Lytic Protease 2011-11-22 2012-05-23 Kelch, B.A.,Salimi, N.L.,Agard, D.A. Functional modulation of a protein folding landscape via side-chain distortion. Proc.Natl.Acad.Sci.USA 2012 109 9414 9419 3URE 22635267 Repack mutant (T181I, W199L, Q210I) of alpha-Lytic Protease 2011-11-22 2012-05-23 Kelch, B.A.,Salimi, N.L.,Agard, D.A. Functional modulation of a protein folding landscape via side-chain distortion. Proc.Natl.Acad.Sci.USA 2012 109 9414 9419 3UWS 26940874 Crystal structure of a clostripain (PARMER_00083) from Parabacteroides merdae ATCC 43184 at 1.70 A resolution 2011-12-02 2012-06-13 McLuskey, K.,Grewal, J.S.,Das, D.,Godzik, A.,Lesley, S.A.,Deacon, A.M.,Coombs, G.H.,Elsliger, M.A.,Wilson, I.A.,Mottram, J.C. Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome. J.Biol.Chem. 2016 291 9482 9491 3V4M Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from Mus musculus at 1.80 A resolution 2011-12-15 2012-06-13 Joint Center for Structural Genomics (JCSG),Partnership for T-Cell Biology (TCELL) Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from Mus musculus at 1.80 A resolution To be published 0 0 0 0 3SG7 23035093 Crystal Structure of GCaMP3-KF(linker 1) 2011-06-14 2012-06-20 Akerboom, J.,Chen, T.W.,Wardill, T.J.,Tian, L.,Marvin, J.S.,Mutlu, S.,Calderon, N.C.,Esposti, F.,Borghuis, B.G.,Sun, X.R.,Gordus, A.,Orger, M.B.,Portugues, R.,Engert, F.,Macklin, J.J.,Filosa, A.,Aggarwal, A.,Kerr, R.A.,Takagi, R.,Kracun, S.,Shigetomi, E.,Khakh, B.S.,Baier, H.,Lagnado, L.,Wang, S.S.,Bargmann, C.I.,Kimmel, B.E.,Jayaraman, V.,Svoboda, K.,Kim, D.S.,Schreiter, E.R.,Looger, L.L. Optimization of a GCaMP calcium indicator for neural activity imaging. J.Neurosci. 2012 32 13819 13840 4FE5 15549109 Crystal structure of the xpt-pbuX guanine riboswitch aptamer domain in complex with hypoxanthine 2012-05-29 2012-06-27 Batey, R.T.,Gilbert, S.D.,Montange, R.K. Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine. Nature 2004 432 411 415 4DIN 22797896 Novel Localization and Quaternary Structure of the PKA RI beta Holoenzyme 2012-01-31 2012-07-04 Ilouz, R.,Bubis, J.,Wu, J.,Yim, Y.Y.,Deal, M.S.,Kornev, A.P.,Ma, Y.,Blumenthal, D.K.,Taylor, S.S. Localization and quaternary structure of the PKA RI Beta holoenzyme Proc.Natl.Acad.Sci.USA 2012 109 12443 12448 4DK3 22561373 Structure of Editosome protein 2012-02-03 2012-07-04 Park, Y.J.,Budiarto, T.,Wu, M.,Pardon, E.,Steyaert, J.,Hol, W.G. The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. Nucleic Acids Res. 2012 40 6966 6977 3UFU 22731813 Structure of rat nitric oxide synthase heme domain in complex with 4-methyl-6-(((3R,4R)-4-((5-(pyridin-2-yl)pentyl)oxy)pyrrolidin-3-yl)methyl)pyridin-2-amine 2011-11-01 2012-07-11 Huang, H.,Ji, H.,Li, H.,Jing, Q.,Labby, K.J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. J.Am.Chem.Soc. 2012 134 11559 11572 3TB5 Crystal Structure of the Enterococcus faecalis Methionine aminopeptidase apo form 2011-08-05 2012-08-08 Kishor, C.,Gumpena, R.,Reddi, R.,Addlagatta, A. Structural studies of Enterococcus faecalis methionine aminopeptidase and design of microbe specific 2,2'-bipyridine based inhibitors MEDCHEMCOMM 2012 3 1406 1412 4FE1 22681901 Improving the Accuracy of Macromolecular Structure Refinement at 7 A Resolution 2012-05-29 2012-08-15 Brunger, A.T.,Adams, P.D.,Fromme, P.,Fromme, R.,Levitt, M.,Schroder, G.F. Improving the accuracy of macromolecular structure refinement at 7 A resolution. Structure 2012 20 957 966 3TH2 Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ 2011-08-18 2012-08-22 Vadivel, K.,Agah, S.,Messer, A.,Cascio, D.,S Bajaj, M.,Krishnaswamy, S.,T Esmon, C.,Padmanabhan, K.,Bajaj, S.P. Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ To be Published 0 0 0 0 3TH3 Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ 2011-08-18 2012-08-22 Vadivel, K.,Agah, S.,Messer, A.,Cascio, D.,Bajaj, M.S.,Krishnaswamy, S.,Esmon, C.T.,Padmanabhan, K.,Bajaj, S.P. Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ To be Published 0 0 0 0 3TH4 Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ 2011-08-18 2012-08-22 Vadivel, K.,Agah, S.,Messer, A.,Cascio, D.,Bajaj, S.M.,Krishnaswamy, S.,Esmon, C.T.,Padmanabhan, K.,Bajaj, S.P. 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DNA octamer D (GTseGTACAC) partially crosslinked with platinum To be Published 0 0 0 0 4FRN 23064232 Crystal structure of the cobalamin riboswitch regulatory element 2012-06-26 2012-10-17 Johnson, J.E.,Reyes, F.E.,Polaski, J.T.,Batey, R.T. B12 cofactors directly stabilize an mRNA regulatory switch. Nature 2012 492 133 137 4FUU Crystal structure of a leucine aminopeptidase precursor (BT_2548) from Bacteroides thetaiotaomicron VPI-5482 at 1.30 A resolution 2012-06-28 2012-10-31 Joint Center for Structural Genomics (JCSG) Crystal structure of a leucine aminopeptidase precursor (BT_2548) from Bacteroides thetaiotaomicron VPI-5482 at 1.30 A resolution To be published 0 0 0 0 4GSJ 23142976 Crystal structure of Atg7 NTD K14A F16A D18A mutant 2012-08-27 2012-11-14 Kaiser, S.E.,Mao, K.,Taherbhoy, A.M.,Yu, S.,Olszewski, J.L.,Duda, D.M.,Kurinov, I.,Deng, A.,Fenn, T.D.,Klionsky, D.J.,Schulman, B.A. Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat.Struct.Mol.Biol. 2012 19 1242 1249 4H1L 23091041 TCR interaction with peptide mimics of nickel offers structural insights in nickel contact allergy 2012-09-10 2012-11-14 Yin, L.,Crawford, F.,Marrack, P.,Kappler, J.W.,Dai, S. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc.Natl.Acad.Sci.USA 2012 109 18517 18522 3UOF Mycobacterium tuberculosis bacterioferritin, BfrA 2011-11-16 2012-11-21 McMath, L.M.,Goulding, C.W. Mycobacterium tuberculosis bacterioferritin, BfrA To be Published 0 0 0 0 4HK3 23175789 I2 Fab (unbound) from CH65-CH67 Lineage 2012-10-14 2012-11-21 Schmidt, A.G.,Xu, H.,Khan, A.R.,O'Donnell, T.,Khurana, S.,King, L.R.,Manischewitz, J.,Golding, H.,Suphaphiphat, P.,Carfi, A.,Settembre, E.C.,Dormitzer, P.R.,Kepler, T.B.,Zhang, R.,Moody, M.A.,Haynes, B.F.,Liao, H.X.,Shaw, D.E.,Harrison, S.C. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc.Natl.Acad.Sci.USA 2013 110 264 269 4GBA 23201271 DCNL complex with N-terminally acetylated NEDD8 E2 peptide 2012-07-26 2012-11-28 Monda, J.K.,Scott, D.C.,Miller, D.J.,Lydeard, J.,King, D.,Harper, J.W.,Bennett, E.J.,Schulman, B.A. Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes. Structure 2013 21 42 53 3UJ3 23275567 Crystal Structure of the synaptic tetramer of the G-Segment Invertase (Gin) 2011-11-07 2012-12-05 Ritacco, C.J.,Kamtekar, S.,Wang, J.,Steitz, T.A. Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase. Nucleic Acids Res. 2013 41 2673 2682 4HCA 23142663 DNA binding by GATA transcription factor-complex 1 2012-09-28 2012-12-05 Chen, Y.,Bates, D.L.,Dey, R.,Chen, P.H.,Machado, A.C.,Laird-Offringa, I.A.,Rohs, R.,Chen, L. DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation. Cell Rep 2012 2 1197 1206 4HFS Crystal structure of an uncharacterized protein (yncM) from Bacillus subtilis subsp. subtilis str. 168 at 1.55 A resolution 2012-10-05 2012-12-05 Joint Center for Structural Genomics (JCSG) Crystal structure of an uncharacterized protein (yncM) from Bacillus subtilis subsp. subtilis str. 168 at 1.55 A resolution To be Published 0 0 0 0 4HLB Crystal structure of an alpha-lytic protease prodomain-like protein (DESPIG_01740) from Desulfovibrio piger ATCC 29098 at 1.80 A resolution 2012-10-16 2012-12-12 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (DESPIG_01740) from Desulfovibrio piger ATCC 29098 at 1.80 A resolution To be published 0 0 0 0 4HW6 Crystal structure of an auxiliary nutrient binding protein (BACOVA_00264) from Bacteroides ovatus ATCC 8483 at 1.70 A resolution 2012-11-07 2012-12-12 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACOVA_00264) from Bacteroides ovatus ATCC 8483 at 1.70 A resolution To be published 0 0 0 0 4I17 Crystal structure of a TPR repeats protein (BF2334) from Bacteroides fragilis NCTC 9343 at 1.50 A resolution 2012-11-20 2012-12-12 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BF2334) from Bacteroides fragilis NCTC 9343 at 1.50 A resolution To be published 0 0 0 0 4GT0 23236058 Structure of dengue virus serotype 1 sE containing stem to residue 421 2012-08-28 2012-12-19 Klein, D.E.,Choi, J.L.,Harrison, S.C. Structure of a dengue virus envelope protein late-stage fusion intermediate. J.Virol. 2013 87 2287 2293 4HSP Crystal structure of a DUF3299 family protein (PA4066) from Pseudomonas aeruginosa PAO1 at 2.45 A resolution 2012-10-30 2012-12-26 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (PA4066) from Pseudomonas aeruginosa PAO1 at 2.45 A resolution To be published 0 0 0 0 4HWM Crystal structure of a lipoprotein YedD (KPN_02420) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.38 A resolution 2012-11-08 2013-01-02 Joint Center for Structural Genomics (JCSG) Crystal structure of a lipoprotein YedD (KPN_02420) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.38 A resolution To be published 0 0 0 0 4ICI Crystal structure of a putative flavoprotein (BACEGG_01620) from Bacteroides eggerthii DSM 20697 at 1.40 A resolution 2012-12-10 2013-01-02 Joint Center for Structural Genomics (JCSG) Crystal structure of a putative flavoprotein (BACEGG_01620) from Bacteroides eggerthii DSM 20697 at 1.40 A resolution To be published 0 0 0 0 4DBZ 24035284 Crystal Structure of V151L Actinorhodin Polyketide Ketoreductase with NADPH 2012-01-16 2013-01-16 Javidpour, P.,Bruegger, J.,Srithahan, S.,Korman, T.P.,Crump, M.P.,Crosby, J.,Burkart, M.D.,Tsai, S.C. The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase. Chem.Biol. 2013 20 1225 1234 4DC0 24035284 Crystal Structure of F189W Actinorhodin Polyketide Ketoreductase with NADPH 2012-01-16 2013-01-16 Javidpour, P.,Bruegger, J.,Srithahan, S.,Korman, T.P.,Crump, M.P.,Crosby, J.,Burkart, M.D.,Tsai, S.C. The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase. Chem.Biol. 2013 20 1225 1234 4DC1 24035284 Crystal Structure of Y202F Actinorhodin Polyketide Ketoreductase with NADPH 2012-01-16 2013-01-16 Javidpour, P.,Bruegger, J.,Srithahan, S.,Korman, T.P.,Crump, M.P.,Crosby, J.,Burkart, M.D.,Tsai, S.C. The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase. Chem.Biol. 2013 20 1225 1234 4I8I Crystal structure of a DUF4886 family protein (BACUNI_01406) from Bacteroides uniformis ATCC 8492 at 1.50 A resolution 2012-12-03 2013-01-16 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACUNI_01406) from Bacteroides uniformis ATCC 8492 at 1.50 A resolution To be published 0 0 0 0 4GAM 23395959 Complex structure of Methane monooxygenase hydroxylase and regulatory subunit 2012-07-25 2013-02-06 Lee, S.J.,McCormick, M.S.,Lippard, S.J.,Cho, U.S. Control of substrate access to the active site in methane monooxygenase. Nature 2013 494 380 384 4IAJ Crystal structure of a conserved domain protein (SP_1775) from Streptococcus pneumoniae TIGR4 at 1.91 A resolution 2012-12-06 2013-02-06 Joint Center for Structural Genomics (JCSG) Crystal structure of a conserved domain protein (SP_1775) from Streptococcus pneumoniae TIGR4 at 1.91 A resolution To be published 0 0 0 0 4IVE Crystal structure of a polyadenylate-binding protein 3 (PABPC3) from Homo sapiens at 2.30 A resolution 2013-01-22 2013-02-06 Joint Center for Structural Genomics (JCSG),Partnership for T-Cell Biology (TCELL) Crystal structure of a polyadenylate-binding protein 3 (PABPC3) from Homo sapiens at 2.30 A resolution To be published 0 0 0 0 4ID2 Crystal structure of a DUF4738 family protein (BACOVA_05496) from Bacteroides ovatus ATCC 8483 at 2.15 A resolution 2012-12-11 2013-02-13 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACOVA_05496) from Bacteroides ovatus ATCC 8483 at 2.15 A resolution To be published 0 0 0 0 4IPB Crystal structure of a DUF2874 family protein (BACOVA_02504) from Bacteroides ovatus ATCC 8483 at 1.62 A resolution 2013-01-09 2013-02-20 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACOVA_02504) from Bacteroides ovatus ATCC 8483 at 1.62 A resolution To be published 0 0 0 0 4IYK Crystal structure of a putative carbohydrate binding protein (BACUNI_04699) from Bacteroides uniformis ATCC 8492 at 2.00 A resolution 2013-01-28 2013-02-20 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACUNI_04699) from Bacteroides uniformis ATCC 8492 at 2.00 A resolution To be published 0 0 0 0 4IAB Crystal structure of a putative monosaccharide binding protein (BACUNI_03039) from Bacteroides uniformis ATCC 8492 at 1.70 A resolution 2012-12-06 2013-02-27 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACUNI_03039) from Bacteroides uniformis ATCC 8492 at 1.66 A resolution To be published 0 0 0 0 4IYJ Crystal structure of a putative acylhydrolase (BACUNI_03406) from Bacteroides uniformis ATCC 8492 at 1.37 A resolution 2013-01-28 2013-03-06 Joint Center for Structural Genomics (JCSG) Crystal structure of a putative acylhydrolase (BACUNI_03406) from Bacteroides uniformis ATCC 8492 at 1.37 A resolution To be published 0 0 0 0 4I6G 23503662 a vertebrate cryptochrome with FAD 2012-11-29 2013-03-13 Xing, W.,Busino, L.,Hinds, T.R.,Marionni, S.T.,Saifee, N.H.,Bush, M.F.,Pagano, M.,Zheng, N. SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature 2013 496 64 68 4IQJ 23478062 Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome 2013-01-11 2013-03-13 Liu, B.,Lin, J.,Steitz, T.A. Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome Structure 2013 21 658 664 4IRT Crystal structure of a putative neuraminidase (BACOVA_03493) from Bacteroides ovatus ATCC 8483 at 1.74 A resolution 2013-01-15 2013-03-13 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACOVA_03493) from Bacteroides ovatus ATCC 8483 at 1.74 A resolution To be published 0 0 0 0 4HPT 23458248 Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide 2012-10-24 2013-03-20 Bastidas, A.C.,Deal, M.S.,Steichen, J.M.,Guo, Y.,Wu, J.,Taylor, S.S. Phosphoryl transfer by protein kinase a is captured in a crystal lattice. J.Am.Chem.Soc. 2013 135 4788 4798 4DSI Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, Se-dGTP and Calcium 2012-02-19 2013-03-27 Gan, J.H.,Abdur, R.,Liu, H.H.,Sheng, J.,Caton-Willians, J.,Soares, A.S.,Huang, Z. Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase To be Published 0 0 0 0 4J1W 23552950 Crystal Structure of Fe(II)-HppE with alternative substrate (R)-1-HPP 2013-02-03 2013-04-03 Chang, W.C.,Dey, M.,Liu, P.,Mansoorabadi, S.O.,Moon, S.J.,Zhao, Z.K.,Drennan, C.L.,Liu, H.W. Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature 2013 496 114 118 4J1X 23552950 Crystal Structure of Fe(II)-HppE with alternative substrate (S)-1-HPP 2013-02-03 2013-04-03 Chang, W.C.,Dey, M.,Liu, P.,Mansoorabadi, S.O.,Moon, S.J.,Zhao, Z.K.,Drennan, C.L.,Liu, H.W. Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature 2013 496 114 118 4JGL Crystal structure of a streptavidin-like protein (BACEGG_01519) from Bacteroides eggerthii DSM 20697 at 1.25 A resolution 2013-03-01 2013-04-03 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACEGG_01519) from Bacteroides eggerthii DSM 20697 at 1.25 A resolution To be published 0 0 0 0 4JJA Crystal structure of a DUF1343 family protein (BF0379) from Bacteroides fragilis NCTC 9343 at 1.30 A resolution 2013-03-07 2013-04-03 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BF0379) from Bacteroides fragilis NCTC 9343 at 1.30 A resolution To be published 0 0 0 0 4JRF 27062925 Crystal structure of a putative cell adhesion protein (BACOVA_01548) from Bacteroides ovatus ATCC 8483 at 1.98 A resolution (PSI Community Target, Nakayama) 2013-03-21 2013-04-03 Xu, Q.,Shoji, M.,Shibata, S.,Naito, M.,Sato, K.,Elsliger, M.A.,Grant, J.C.,Axelrod, H.L.,Chiu, H.J.,Farr, C.L.,Jaroszewski, L.,Knuth, M.W.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Curtis, M.A.,Nakayama, K.,Wilson, I.A. A Distinct Type of Pilus from the Human Microbiome. Cell 2016 165 690 703 4J9V 23598339 Crystal Structure of the TrkA Gating ring bound to ATP-gamma-S 2013-02-17 2013-04-10 Cao, Y.,Pan, Y.,Huang, H.,Jin, X.,Levin, E.J.,Kloss, B.,Zhou, M. Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature 2013 496 317 322 4JQR Crystal structure of a DUF4465 family protein (BACCAC_02373) from Bacteroides caccae ATCC 43185 at 2.05 A resolution 2013-03-20 2013-04-10 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACCAC_02373) from Bacteroides caccae ATCC 43185 at 2.05 A resolution To be published 0 0 0 0 4JQT Crystal structure of a putative glycosyl hydrolase (BT3469) from Bacteroides thetaiotaomicron VPI-5482 at 2.49 A resolution 2013-03-20 2013-04-17 Joint Center for Structural Genomics (JCSG) Crystal structure of a putative glycosyl hydrolase (BT3469) from Bacteroides thetaiotaomicron VPI-5482 at 2.49 A resolution To be published 0 0 0 0 4HDJ 23189157 Crystal Structure of BamB from Pseudomonas aeruginosa 2012-10-02 2013-04-24 Jansen, K.B.,Baker, S.L.,Sousa, M.C. Crystal structure of BamB from Pseudomonas aeruginosa and functional evaluation of its conserved structural features. Plos One 2012 7 0 0 4EV8 Crystal structure of mouse catenin beta-59 in 2.4M urea. 2012-04-26 2013-05-01 Wang, C.,Zhang, G.Y. Crystal structure of mouse catenin beta-59 in 2.4M urea. TO BE PUBLISHED 0 0 0 0 4EV9 Crystal Structure of Mouse Catenin beta-59 in 4.0M urea 2012-04-26 2013-05-01 Wang, C.,Zhang, G.Y. Crystal Structure of Mouse Catenin beta-59 in 4.0M urea TO BE PUBLISHED 0 0 0 0 4EVA Crystal Structure of Mouse Catenin beta-59 in 5.6M urea 2012-04-26 2013-05-01 Wang, C.,Zhang, G.Y. Crystal Structure of Mouse Catenin beta-59 in 5.6M urea TO BE PUBLISHED 0 0 0 0 4EVP Crystal Structure of Mouse Catenin beta-59 in 7.2M urea 2012-04-26 2013-05-01 Wang, C.,Zhang, G.Y. Crystal Structure of Mouse Catenin beta-59 in 7.2M urea TO BE PUBLISHED 0 0 0 0 4EVT Crystal Structure of Mouse Catenin beta-59 in 8.3M urea 2012-04-26 2013-05-01 Wang, C.,Zhang, G.Y. Crystal Structure of Mouse Catenin beta-59 in 8.3M urea TO BE PUBLISHED 0 0 0 0 4HF2 23644595 Crystal Structure of E43A IscR mutant bound to its promoter 2012-10-04 2013-05-08 Rajagopalan, S.,Teter, S.J.,Zwart, P.H.,Brennan, R.G.,Phillips, K.J.,Kiley, P.J. Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity. Nat.Struct.Mol.Biol. 2013 20 740 747 4FVY 23586781 Structure of rat nNOS heme domain in complex with N(omega)-hydroxy- N(omega)-methyl-L-arginine 2012-06-29 2013-05-15 Jansen Labby, K.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction Biochemistry 2013 52 3062 3073 4JR9 23665960 Crystal structure of nitrate/nitrite exchanger NarK 2013-03-21 2013-05-15 Zheng, H.,Wisedchaisri, G.,Gonen, T. Crystal structure of a nitrate/nitrite exchanger. Nature 2013 497 647 651 4JRE 23665960 Crystal structure of nitrate/nitrite exchanger NarK with nitrite bound 2013-03-21 2013-05-15 Zheng, H.,Wisedchaisri, G.,Gonen, T. Crystal structure of a nitrate/nitrite exchanger. Nature 2013 497 647 651 4JOM 23672456 Structure of E. coli Pol III 3mPHP mutant 2013-03-18 2013-05-29 Barros, T.,Guenther, J.,Kelch, B.,Anaya, J.,Prabhakar, A.,O Donnell, M.,Kuriyan, J.,Lamers, M.H. A structural role for the PHP domain in E. coli DNA polymerase III. Bmc Struct.Biol. 2013 13 8 8 4FFA 23762287 Sulfatase from Mycobacterium tuberculosis 2012-05-31 2013-06-05 Sogi, K.M.,Gartner, Z.J.,Breidenbach, M.A.,Appel, M.J.,Schelle, M.W.,Bertozzi, C.R. Mycobacterium tuberculosis Rv3406 Is a Type II Alkyl Sulfatase Capable of Sulfate Scavenging. Plos One 2013 8 0 0 4KQB 23754375 crystal structure of the Golgi casein kinase with Mn/ADP bound 2013-05-14 2013-06-26 Xiao, J.,Tagliabracci, V.S.,Wen, J.,Kim, S.A.,Dixon, J.E. Crystal structure of the Golgi casein kinase. Proc.Natl.Acad.Sci.USA 2013 110 10574 10579 4L7A Crystal structure of a putative zinc-binding metallo-peptidase (BACCAC_01431) from Bacteroides caccae ATCC 43185 at 2.10 A resolution 2013-06-13 2013-07-03 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BACCAC_01431) from Bacteroides caccae ATCC 43185 at 2.10 A resolution To be published 0 0 0 0 4L8K Crystal structure of a putative peptidase (PARMER_02772) from Parabacteroides merdae ATCC 43184 at 2.26 A resolution 2013-06-17 2013-07-03 Joint Center for Structural Genomics (JCSG) Crystal structure of a putative peptidase (PARMER_02772) from Parabacteroides merdae ATCC 43184 at 2.26 A resolution To be published 0 0 0 0 4KW0 Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-G modification 2013-05-23 2013-07-17 Jiang, S.,Gan, J.,Sheng, J.,Sun, H.,Huang, Z. Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-G modification TO BE PUBLISHED 0 0 0 0 4I2Y 23459413 Crystal Structure of the genetically encoded calcium indicator RGECO1 2012-11-23 2013-07-24 Akerboom, J.,Carreras Calderon, N.,Tian, L.,Wabnig, S.,Prigge, M.,Tolo, J.,Gordus, A.,Orger, M.B.,Severi, K.E.,Macklin, J.J.,Patel, R.,Pulver, S.R.,Wardill, T.J.,Fischer, E.,Schuler, C.,Chen, T.W.,Sarkisyan, K.S.,Marvin, J.S.,Bargmann, C.I.,Kim, D.S.,Kugler, S.,Lagnado, L.,Hegemann, P.,Gottschalk, A.,Schreiter, E.R.,Looger, L.L. Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Front Mol Neurosci 2013 6 2 2 4LDA Crystal structure of a CheY-like protein (tadZ) from Pseudomonas aeruginosa PAO1 at 2.70 A resolution 2013-06-24 2013-07-24 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (tadZ) from Pseudomonas aeruginosa PAO1 at 2.70 A resolution (PSI Community Target, Shapiro) To be Published 0 0 0 0 4L3U Crystal structure of a DUF3571 family protein (ABAYE3784) from Acinetobacter baumannii AYE at 1.95 A resolution 2013-06-06 2013-07-31 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (ABAYE3784) from Acinetobacter baumannii AYE at 1.95 A resolution To be published 0 0 0 0 4KJP 24036509 Structure of the CLC-ec1 deltaNC construct in the absence of halide 2013-05-03 2013-08-21 Lim, H.H.,Stockbridge, R.B.,Miller, C. Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter. Nat.Chem.Biol. 2013 9 721 725 4KK6 24036509 Structure of CLC-ec1 deltaNC construct in 20mM Bromide 2013-05-05 2013-08-21 Lim, H.H.,Stockbridge, R.B.,Miller, C. Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter. Nat.Chem.Biol. 2013 9 721 725 4KK8 24036509 Structure of the E148Q mutant of CLC-ec1 deltaNC construct in 100mM fluoride 2013-05-05 2013-08-21 Lim, H.H.,Stockbridge, R.B.,Miller, C. Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter. Nat.Chem.Biol. 2013 9 721 725 4KKB 24036509 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 20mM fluoride and 20mM Bromide 2013-05-05 2013-08-21 Lim, H.H.,Stockbridge, R.B.,Miller, C. Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter. Nat.Chem.Biol. 2013 9 721 725 4KKC 24036509 Structure of the E148A mutant of CLC-ec1 deltaNC construct in 20mM Bromide 2013-05-05 2013-08-21 Lim, H.H.,Stockbridge, R.B.,Miller, C. Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter. Nat.Chem.Biol. 2013 9 721 725 4L8O Crystal structure of a bile-acid 7-alpha dehydratase (CLOHYLEM_06634) from Clostridium hylemonae DSM 15053 at 2.20 A resolution 2013-06-17 2013-08-21 Joint Center for Structural Genomics (JCSG) Crystal structure of a bile-acid 7-alpha dehydratase (CLOHYLEM_06634) from Clostridium hylemonae DSM 15053 at 2.20 A resolution To be published 0 0 0 0 4L9M 23908768 Autoinhibited state of the Ras-specific exchange factor RasGRP1 2013-06-18 2013-08-21 Iwig, J.S.,Vercoulen, Y.,Das, R.,Barros, T.,Limnander, A.,Che, Y.,Pelton, J.G.,Wemmer, D.E.,Roose, J.P.,Kuriyan, J. Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife 2013 2 0 0 4L9U 23908768 Structure of C-terminal coiled coil of RasGRP1 2013-06-18 2013-08-21 Iwig, J.S.,Vercoulen, Y.,Das, R.,Barros, T.,Limnander, A.,Che, Y.,Pelton, J.G.,Wemmer, D.E.,Roose, J.P.,Kuriyan, J. Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife 2013 2 0 0 4LOU Structure of the E148Q mutant of CLC-ec1 deltaNC construct in the absence of halide 2013-07-13 2013-08-28 Lim, H.-H.,Stockbridge, R.B.,Miller, C. A fluoride interloper in a CLC-type Cl /H+ antiporter Nat.Chem.Biol. 2013 0 0 0 4MCJ Crystal structure of a putative nucleoside deoxyribosyltransferase (BDI_0649) from Parabacteroides distasonis ATCC 8503 at 2.40 A resolution 2013-08-21 2013-09-04 Joint Center for Structural Genomics (JCSG) Crystal structure of a hypothetical protein (BDI_0649) from Parabacteroides distasonis ATCC 8503 at 2.40 A resolution To be published 0 0 0 0 4HWT 23362938 Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor 2012-11-08 2013-09-18 Teng, M.,Hilgers, M.T.,Cunningham, M.L.,Borchardt, A.,Locke, J.B.,Abraham, S.,Haley, G.,Kwan, B.P.,Hall, C.,Hough, G.W.,Shaw, K.J.,Finn, J. Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem. 2013 56 1748 1760 4JVA 23978166 Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog 2013-03-25 2013-09-18 Brown, S.H.,Cheng, C.Y.,Saldanha, S.A.,Wu, J.,Cottam, H.B.,Sankaran, B.,Taylor, S.S. Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs. Acs Chem.Biol. 2013 8 2164 2172 4H25 23091041 TCR interaction with peptide mimics of nickel offers structure insights to nickel contact allergy 2012-09-12 2013-10-16 Yin, L.,Crawford, F.,Marrack, P.,Kappler, J.W.,Dai, S. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc.Natl.Acad.Sci.USA 2012 109 18517 18522 4H26 23091041 TCR interaction with peptide mimics of nickel offers structure insight to nickel contact allergy 2012-09-12 2013-10-16 Yin, L.,Crawford, F.,Marrack, P.,Kappler, J.W.,Dai, S. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc.Natl.Acad.Sci.USA 2012 109 18517 18522 4M0N Crystal structure of a putative anti-sigma factor (BDI_1681) from Parabacteroides distasonis ATCC 8503 at 1.65 A resolution 2013-08-01 2013-10-16 Joint Center for Structural Genomics (JCSG) Crystal structure of a conserved hypothetical protein, putative anti-sigma factor (BDI_1681) from Parabacteroides distasonis ATCC 8503 at 1.65 A resolution To be published 0 0 0 0 3W8X 24162851 The complex structure of EncM with trifluorotriketide 2013-03-22 2013-10-30 Teufel, R.,Miyanaga, A.,Michaudel, Q.,Stull, F.,Louie, G.,Noel, J.P.,Baran, P.S.,Palfey, B.,Moore, B.S. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature 2013 503 552 556 3W8Z 24162851 The complex structure of EncM with hydroxytetraketide 2013-03-22 2013-10-30 Teufel, R.,Miyanaga, A.,Michaudel, Q.,Stull, F.,Louie, G.,Noel, J.P.,Baran, P.S.,Palfey, B.,Moore, B.S. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature 2013 503 552 556 4C97 24150936 Cas6 (TTHA0078) H37A mutant 2013-10-02 2013-11-06 Niewoehner, O.,Jinek, M.,Doudna, J.A. Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases. Nucleic Acids Res. 2014 42 1341 0 4C98 24150936 Thermus thermophilus Cas6 (TTHB231) 2013-10-02 2013-11-06 Niewoehner, O.,Jinek, M.,Doudna, J.A. Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases. Nucleic Acids Res. 2014 42 1341 0 4MLW 24189072 Crystal structure of non-myristoylated recoverin at 1.45 A resolution with calcium bound to EF-hand 3 2013-09-06 2013-11-13 Ranaghan, M.J.,Kumar, R.P.,Chakrabarti, K.S.,Buosi, V.,Kern, D.,Oprian, D.D. A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin. J.Biol.Chem. 2013 288 36160 36167 4L8G 24256730 Crystal Structure of K-Ras G12C, GDP-bound 2013-06-17 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4LIJ Crystal structure of a far upstream element (FUSE) binding protein 1 (FUBP1) from Homo sapiens at 1.95 A resolution 2013-07-02 2013-11-27 Joint Center for Structural Genomics (JCSG),Partnership for T-Cell Biology Crystal structure of a far upstream element (FUSE) binding protein 1 (FUBP1) from Homo sapiens at 1.95 A resolution To be published 0 0 0 0 4LUC 24256730 Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C 2013-07-25 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4LYF 24256730 Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C 2013-07-31 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4LYH 24256730 Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C 2013-07-31 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4LYJ 24256730 Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group 2013-07-31 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4M1O 24256730 Crystal Structure of small molecule vinylsulfonamide 7 covalently bound to K-Ras G12C 2013-08-03 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4M1S 24256730 Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C 2013-08-04 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4M1T 24256730 Crystal Structure of small molecule vinylsulfonamide 14 covalently bound to K-Ras G12C 2013-08-04 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 503 548 551 4M1Y 24256730 Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C 2013-08-04 2013-11-27 Ostrem, J.M.,Peters, U.,Sos, M.L.,Wells, J.A.,Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. 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J.Am.Chem.Soc. 2014 136 13916 13924 4P5M 24995984 Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between Allergic Hypersensitivity and Autoimmunity 2014-03-18 2014-08-27 Clayton, G.M.,Wang, Y.,Crawford, F.,Novikov, A.,Wimberly, B.T.,Kieft, J.S.,Falta, M.T.,Bowerman, N.A.,Marrack, P.,Fontenot, A.P.,Dai, S.,Kappler, J.W. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell 2014 158 132 142 4J8M 25175806 Aurora A in complex with CD532 2013-02-14 2014-09-10 Gustafson, W.C.,Meyerowitz, J.G.,Nekritz, E.A.,Chen, J.,Benes, C.,Charron, E.,Simonds, E.F.,Seeger, R.,Matthay, K.K.,Hertz, N.T.,Eilers, M.,Shokat, K.M.,Weiss, W.A. Drugging MYCN through an Allosteric Transition in Aurora Kinase A. Cancer Cell 2014 26 414 427 4J8N 25175806 Aurora A Kinase Apo 2013-02-14 2014-09-10 Gustafson, W.C.,Meyerowitz, J.G.,Nekritz, E.A.,Chen, J.,Benes, C.,Charron, E.,Simonds, E.F.,Seeger, R.,Matthay, K.K.,Hertz, N.T.,Eilers, M.,Shokat, K.M.,Weiss, W.A. Drugging MYCN through an Allosteric Transition in Aurora Kinase A. Cancer Cell 2014 26 414 427 4OQ8 25195746 Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using icosahedral constraints 2014-02-07 2014-09-10 Larson, S.B.,Day, J.S.,McPherson, A. Satellite tobacco mosaic virus refined to 1.4 angstrom resolution. Acta Crystallogr.,Sect.D 2014 70 2316 2330 4OQ9 25195746 Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints 2014-02-07 2014-09-10 Larson, S.B.,Day, J.S.,McPherson, A. Satellite tobacco mosaic virus refined to 1.4 angstrom resolution. Acta Crystallogr.,Sect.D 2014 70 2316 2330 4N4X Crystal Structure of the MBP fused human SPLUNC1 (native form) 2013-10-08 2014-09-17 Ning, F.,Wang, C.,Niu, L.,Chu, H.W.,Zhang, G. Lipid ligands of human SPLUNC1 To be Published 0 0 0 0 4R1S 25217505 Crystal structure of Petunia hydrida cinnamoyl-CoA reductase 2014-08-07 2014-10-01 Pan, H.,Zhou, R.,Louie, G.V.,Muhlemann, J.K.,Bomati, E.K.,Bowman, M.E.,Dudareva, N.,Dixon, R.A.,Noel, J.P.,Wang, X. Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell 2014 26 3709 3727 4R1T 25217505 Crystal structure of Petunia hydrida cinnamoyl-CoA reductase 2014-08-07 2014-10-01 Pan, H.,Zhou, R.,Louie, G.V.,Muhlemann, J.K.,Bomati, E.K.,Bowman, M.E.,Dudareva, N.,Dixon, R.A.,Noel, J.P.,Wang, X. Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-Alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis. Plant Cell 2014 26 3709 3727 4TQL 25342806 Computationally designed three helix bundle 2014-06-11 2014-10-15 Huang, P.S.,Oberdorfer, G.,Xu, C.,Pei, X.Y.,Nannenga, B.L.,Rogers, J.M.,DiMaio, F.,Gonen, T.,Luisi, B.,Baker, D. High thermodynamic stability of parametrically designed helical bundles. Science 2014 346 481 485 4Q3G 25372696 Structure of the OsSERK2 leucine rich repeat extracellular domain 2014-04-11 2014-11-12 McAndrew, R.,Pruitt, R.N.,Kamita, S.G.,Pereira, J.H.,Majumdar, D.,Hammock, B.D.,Adams, P.D.,Ronald, P.C. Structure of the OsSERK2 leucine-rich repeat extracellular domain. Acta Crystallogr.,Sect.D 2014 70 3080 3086 4Q3I 25372696 Structure of the OsSERK2 leucine rich repeat extracellular domain 2014-04-11 2014-11-12 McAndrew, R.,Pruitt, R.N.,Kamita, S.G.,Pereira, J.H.,Majumdar, D.,Hammock, B.D.,Adams, P.D.,Ronald, P.C. Structure of the OsSERK2 leucine-rich repeat extracellular domain. Acta Crystallogr.,Sect.D 2014 70 3080 3086 4O0I Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with 2'-MeSe-arabino-guanosine derivatized DNA 2013-12-13 2014-12-17 Jiang, S.,Gan, J.,Sun, H.,Huang, Z. Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with 2'-MeSe-arabino-guanosine derivatized DNA TO BE PUBLISHED 0 0 0 0 4D37 25489882 Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-{[(1R,2R)-2-(3-fluorophenyl)cyclopropyl]methyl}-2-[2-(1H-imidazol-1-yl) pyrimidin-4-yl]ethanamine 2014-10-20 2014-12-24 Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem. 2015 58 1067 0 4D38 25489882 Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine 2014-10-20 2014-12-24 Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem. 2015 58 1067 0 4V3U 25489882 Structure of human nNOS R354A G357D mutant heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl-3-(pyridin-3-yl) propan-1-amine 2014-10-20 2014-12-24 Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem. 2015 58 1067 0 4D3V 25522110 Structure of Bacillus subtilis Nitric Oxide Synthase I218V in complex with N-{3-[(1S)-2-(3-{(Z)-[amino(thiophen-2-yl)methylidene]amino}phenoxy)-1-hydroxyethyl]phenyl}thiophene-2-carboximidamide 2014-10-23 2015-01-14 Holden, J.K.,Kang, S.,Hollingsworth, S.A.,Li, H.,Lim, N.,Chen, S.,Huang, H.,Xue, F.,Tang, W.,Silverman, R.B.,Poulos, T.L. Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors. J.Med.Chem. 2015 58 994 0 4WNO 25551253 Structure of ULK1 bound to an inhibitor 2014-10-14 2015-01-14 Lazarus, M.B.,Novotny, C.J.,Shokat, K.M. Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors. Acs Chem.Biol. 2015 10 257 261 4WNP 25551253 Structure of ULK1 bound to a potent inhibitor 2014-10-14 2015-01-14 Lazarus, M.B.,Novotny, C.J.,Shokat, K.M. Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors. Acs Chem.Biol. 2015 10 257 261 4P5K 24995984 Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between Allergy and Autoimmunity 2014-03-17 2015-01-21 Clayton, G.M.,Wang, Y.,Crawford, F.,Novikov, A.,Wimberly, B.T.,Kieft, J.S.,Falta, M.T.,Bowerman, N.A.,Marrack, P.,Fontenot, A.P.,Dai, S.,Kappler, J.W. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell 2014 158 132 142 4XVV Crystal structure of an Acid stress chaperone HdeB (KPN_03484) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.70 A resolution 2015-01-28 2015-02-11 Joint Center for Structural Genomics (JCSG) Crystal structure of an Acid stress chaperone HdeB (KPN_03484) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.70 A resolution To be published 0 0 0 0 4UEU 25700521 Tyrosine kinase AS - a common ancestor of Src and Abl 2014-12-18 2015-02-18 Wilson, C.,Agafonov, R.V.,Hoemberger, M.,Kutter, S.,Zorba, A.,Halpin, J.,Buosi, V.,Otten, R.,Waterman, D.,Theobald, D.L.,Kern, D. Kinase Dynamics. Using Ancient Protein Kinases to Unravel a Modern Cancer Drug'S Mechanism. Science 2015 347 882 0 4CSV 25700521 Tyrosine kinase AS - a common ancestor of Src and Abl bound to Gleevec 2014-03-10 2015-03-04 Wilson, C.,Agafonov, R.V.,Hoemberger, M.,Kutter, S.,Zorba, A.,Halpin, J.,Buosi, V.,Otten, R.,Waterman, D.,Theobald, D.L.,Kern, D. Kinase Dynamics. Using Ancient Protein Kinases to Unravel a Modern Cancer Drug'S Mechanism. Science 2015 347 882 0 4XLW 25700513 Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) 2015-01-13 2015-03-04 Luca, V.C.,Jude, K.M.,Pierce, N.W.,Nachury, M.V.,Fischer, S.,Garcia, K.C. Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science 2015 347 847 853 4Y93 25699547 Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk) 2015-02-16 2015-03-18 Wang, Q.,Vogan, E.M.,Nocka, L.M.,Rosen, C.E.,Zorn, J.A.,Harrison, S.C.,Kuriyan, J. Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife 2015 4 0 0 4Y94 25699547 Crystal structure of the PH-TH module of Bruton's tyrosine kinase bound to inositol hexakisphosphate 2015-02-16 2015-03-18 Wang, Q.,Vogan, E.M.,Nocka, L.M.,Rosen, C.E.,Zorn, J.A.,Harrison, S.C.,Kuriyan, J. 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Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N. Protein Sci. 2015 24 823 831 4QPY 25752542 Crystal structure of C1QL2 2014-06-25 2015-04-15 Ressl, S.,Vu, B.K.,Vivona, S.,Martinelli, D.C.,Sudhof, T.C.,Brunger, A.T. Structures of C1q-like Proteins Reveal Unique Features among the C1q/TNF Superfamily. Structure 2015 23 688 699 4QQ2 25752542 Crystal structure of C1QL1 2014-06-26 2015-04-15 Ressl, S.,Vu, B.K.,Vivona, S.,Martinelli, D.C.,Sudhof, T.C.,Brunger, A.T. Structures of C1q-like Proteins Reveal Unique Features among the C1q/TNF Superfamily. Structure 2015 23 688 699 4XUF 25837374 Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220) 2015-01-25 2015-04-15 Zorn, J.A.,Wang, Q.,Fujimura, E.,Barros, T.,Kuriyan, J. Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220). Plos One 2015 10 0 0 5AGK 25874809 Structure of rat neuronal nitric oxide synthase heme domain in complex with (2S)-2-Amino-5-(2-(methylsulfinyl)acetimidamido) pentanoic acid 2015-02-02 2015-04-29 Tang, W.,Li, H.,Doud, E.H.,Chen, Y.,Choing, S.,Plaza, C.,Kelleher, N.L.,Poulos, T.L.,Silverman, R.B. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid. J.Am.Chem.Soc. 2015 137 5980 0 4P4W 25915729 Dodecamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (ORN)YLL(PHI)YTE(ORN)KVA(MVA)AVK 2014-03-13 2015-05-06 Spencer, R.K.,Kreutzer, A.G.,Salveson, P.J.,Li, H.,Nowick, J.S. X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin. 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J.Am.Chem.Soc. 2015 137 6304 6311 4ZJS 19890000 Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A. 2015-04-29 2015-05-13 Luo, J.,Taylor, P.,Losen, M.,de Baets, M.H.,Shelton, G.D.,Lindstrom, J. Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity. J. Neurosci. 2009 29 13898 13908 4ZK4 Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane 2015-04-29 2015-05-13 Bobango, J.,Wu, J.,Talley, T.T. Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane. To be Published 0 0 0 0 4WBB 26158466 Single Turnover Autophosphorylation Cycle of the PKA RIIb Holoenzyme 2014-09-02 2015-05-20 Zhang, P.,Knape, M.J.,Ahuja, L.G.,Keshwani, M.M.,King, C.C.,Sastri, M.,Herberg, F.W.,Taylor, S.S. Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme. Plos Biol. 2015 13 0 0 5ALA 25941976 Structure of Leishmania major peroxidase D211R mutant (low res) 2015-03-07 2015-05-20 Chreifi, G.,Hollingsworth, S.A.,Li, H.,Tripathi, S.,Arce, A.P.,Magana-Garcia, H.I.,Poulos, T.L. Enzymatic Mechanism of Leishmania major Peroxidase and the Critical Role of Specific Ionic Interactions. Biochemistry 2015 54 3328 3336 4YJZ 25959776 Human antibody H2526 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006 2015-03-03 2015-05-27 Schmidt, A.G.,Therkelsen, M.D.,Stewart, S.,Kepler, T.B.,Liao, H.X.,Moody, M.A.,Haynes, B.F.,Harrison, S.C. Viral receptor-binding site antibodies with diverse germline origins. Cell 2015 161 1026 1034 4ZRU X-ray crystal structure of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) in complex with 3-[2-[(2S)-pyrrolidin-2-yl]ethynyl]pyridine (TI-5180) 2015-05-12 2015-05-27 Talley, T.T. Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs, and Structural Features of a High-Affinity, Non-selective NNR Ligand-AChBP Co-crystal Structure To be Published 0 0 0 0 4TN5 Crystal Structure of Predicted Fructose Specific IIB from Escherichia Coli 2014-06-03 2015-06-10 Kim, M.S.,Shin, D.H.,Lee, J.,Joo, K.,Park, J.,Lee, D.,Berry, E.A.,Jhon, G.-J. High-accuracy protein modeling and its application to molecular replacement of crystallographic phasing To Be Published 0 0 0 0 4YSB 26082492 Crystal structure of ETHE1 from Myxococcus xanthus 2015-03-17 2015-06-24 Sattler, S.A.,Wang, X.,Lewis, K.M.,DeHan, P.J.,Park, C.M.,Xin, Y.,Liu, H.,Xian, M.,Xun, L.,Kang, C. Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily. J.Biol.Chem. 2015 290 18914 18923 5A1R 26066995 Crystal structure of cytochrome P450 3A4 bound to progesterone 2015-05-04 2015-06-24 Sevrioukova, I.F.,Poulos, T.L. Anion-Dependent Stimulation of Cyp3A4 Monooxygenase Biochemistry 2015 54 4083 0 5BP0 X-ray crystal structure of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) in complex with 5-Fluoronicotine (TI-4650) 2015-05-27 2015-06-24 Bobango, J.,Sankaran, B.,Park, J.F.,Wu, J.,Talley, T.T. Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs To Be Published 0 0 0 0 4D7I 26091171 Structure of Bacillus subtilis nitric oxide synthase I218V in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4-methylpyridin-2- amine 2014-11-25 2015-07-01 Holden, J.K.,Kang, S.,Beasley, F.C.,Cinelli, M.A.,Li, H.,Roy, S.G.,Dejam, D.,Edinger, A.L.,Nizet, V.,Silverman, R.B.,Poulos, T.L. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus Chem.Biol. 2015 22 785 0 4YQX 25992858 Mouse IL-2 Bound to JES6-1 scFv Fragment 2015-03-13 2015-07-01 Spangler, J.B.,Tomala, J.,Luca, V.C.,Jude, K.M.,Dong, S.,Ring, A.M.,Votavova, P.,Pepper, M.,Kovar, M.,Garcia, K.C. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity 2015 42 815 825 4U7W 26235055 The crystal structure of the terminal R domain from the myxalamid PKS-NRPS biosynthetic pathway 2014-07-31 2015-08-12 Barajas, J.F.,Phelan, R.M.,Schaub, A.J.,Kliewer, J.T.,Kelly, P.J.,Jackson, D.R.,Luo, R.,Keasling, J.D.,Tsai, S.C. Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols. Chem.Biol. 2015 22 1018 1029 5A43 26344196 Crystal structure of a dual topology fluoride ion channel. 2015-06-04 2015-09-02 Stockbridge, R.B.,Kolmakova-Partensky, L.,Shane, T.,Koide, A.,Koide, S.,Miller, C.,Newstead, S. Crystal Structures of a Double-Barrelled Fluoride Ion Channel. Nature 2015 525 548 0 5DHI 26378620 Nicotiana tabacum 5-epi-aristolochene synthase mutant W273E - nonalkylated 2015-08-31 2015-09-16 Kersten, R.D.,Diedrich, J.K.,Yates, J.R.,Noel, J.P. Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases. 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Biochemistry 2016 55 6314 6326 5KZU Crystal structure of an acetylcholine binding protein from Aplysia californica (Ac-AChBP) in complex with click chemistry compound 9-[[1-[8-methyl-8-(2-phenylethyl)-8-azoniabicyclo[3.2.1]octan-3-yl]triazol-4-yl]methyl]carbazole 2016-07-25 2016-11-02 Bobango, J.,Wu, J.,Talley, I.T.,Sankaran, B.,Talley, T.T. Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) in complex with click chemistry compound 9-[[1-[8-methyl-8-(2-phenylethyl)-8-azoniabicyclo[3.2.1]octan-3-yl]triazol-4-yl]methyl]carbazole To Be Published 0 0 0 0 5IBT 27820604 UCA Fab (unbound) from 6515 Lineage 2016-02-22 2016-11-09 Raymond, D.D.,Stewart, S.M.,Lee, J.,Ferdman, J.,Bajic, G.,Do, K.T.,Ernandes, M.J.,Suphaphiphat, P.,Settembre, E.C.,Dormitzer, P.R.,Del Giudice, G.,Finco, O.,Kang, T.H.,Ippolito, G.C.,Georgiou, G.,Kepler, T.B.,Haynes, B.F.,Moody, M.A.,Liao, H.X.,Schmidt, A.G.,Harrison, S.C. 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Biochemistry 2023 62 3206 3213 8SU8 37974623 Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde). 2023-05-11 2023-12-06 Francisco, K.R.,Bruystens, J.,Varricchio, C.,McCurdy, S.,Wu, J.,Lopez-Ramirez, M.A.,Ginsberg, M.,Caffrey, C.R.,Brancale, A.,Gingras, A.R.,Hixon, M.S.,Ballatore, C. Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci 2023 6 1651 1658 8T7V 37974623 Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde) 2023-06-21 2023-12-06 Francisco, K.R.,Bruystens, J.,Varricchio, C.,McCurdy, S.,Wu, J.,Lopez-Ramirez, M.A.,Ginsberg, M.,Caffrey, C.R.,Brancale, A.,Gingras, A.R.,Hixon, M.S.,Ballatore, C. Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci 2023 6 1651 1658 8F81 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM777 2022-11-21 2023-12-13 Liu, L.,Battaile, K.P.,Lovell, S.,Staker, B.L. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM777 To be published 0 0 0 0 8F82 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM845 2022-11-21 2023-12-13 Liu, L.,Battaile, K.P.,Lovell, S.,Staker, B.L. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM845 To be published 0 0 0 0 8F83 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM846 2022-11-21 2023-12-13 Seibold, S.,Battaile, K.P.,Lovell, S.,Staker, B.L. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM846 To be published 0 0 0 0 8T09 37974623 Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-ethynyl-2-hydroxy-1-naphthaldehyde) 2023-05-31 2023-12-13 Francisco, K.R.,Bruystens, J.,Varricchio, C.,McCurdy, S.,Wu, J.,Lopez-Ramirez, M.A.,Ginsberg, M.,Caffrey, C.R.,Brancale, A.,Gingras, A.R.,Hixon, M.S.,Ballatore, C. Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci 2023 6 1651 1658 8UH7 38177685 Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog 2023-10-07 2023-12-13 Marcus, K.,Huang, Y.,Subramanian, S.,Gee, C.L.,Gorday, K.,Ghaffari-Kashani, S.,Luo, X.R.,Zheng, L.,O'Donnell, M.,Subramaniam, S.,Kuriyan, J. Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat.Struct.Mol.Biol. 2024 0 0 0 8SQF 38117688 OXA-48 bound to inhibitor CDD-2725 2023-05-04 2024-01-03 Park, S.,Fan, J.,Chamakuri, S.,Palaniappan, M.,Sharma, K.,Qin, X.,Wang, J.,Tan, Z.,Judge, A.,Hu, L.,Sankaran, B.,Li, F.,Prasad, B.V.V.,Matzuk, M.M.,Palzkill, T. Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. 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