PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 2BNI 16008357 pLI mutant E20C L16G Y17H, antiparallel 2005-03-24 2005-03-30 Yadav, M.K.,Redman, J.E.,Leman, L.J.,Alvarez-Gutierrez, J.M.,Zhang, Y.,Stout, C.D.,Ghadiri, M.R. Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides Biochemistry 2005 44 9723 0 1ZB7 16008342 Crystal Structure of Botulinum Neurotoxin Type G Light Chain 2005-04-07 2005-07-05 Arndt, J.W.,Yu, W.,Bi, F.,Stevens, R.C. Crystal structure of botulinum neurotoxin type g light chain: serotype divergence in substrate recognition Biochemistry 2005 44 9574 9580 1YKS 16051820 Crystal structure of yellow fever virus NS3 helicase 2005-01-18 2005-08-23 Wu, J.,Bera, A.K.,Kuhn, R.J.,Smith, J.L. Structure of the flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing. J.Virol. 2005 79 10268 10277 2B33 CRYSTAL STRUCTURE OF A PUTATIVE ENDORIBONUCLEASE (TM0215) FROM THERMOTOGA MARITIMA MSB8 AT 2.30 A RESOLUTION 2005-09-19 2005-09-27 Joint Center for Structural Genomics (JCSG) Crystal structure of Protein synthesis inhibitor, putative (tm0215) from THERMOTOGA MARITIMA at 2.30 A resolution To be published 0 0 0 0 2ATF 16492780 X-RAY STRUCTURE OF cysteine dioxygenase type I FROM MUS MUSCULUS MM.241056 2005-08-24 2005-10-18 McCoy, J.G.,Bailey, L.J.,Bitto, E.,Bingman, C.A.,Aceti, D.J.,Fox, B.G.,Phillips, G.N. Structure and mechanism of mouse cysteine dioxygenase. Proc.Natl.Acad.Sci.Usa 2006 103 3084 3089 2ETS 18324683 CRYSTAL STRUCTURE OF A BACTERIAL DOMAIN OF UNKNOWN FUNCTION FROM DUF1798 FAMILY (MW1337) FROM STAPHYLOCOCCUS AUREUS SUBSP. AUREUS AT 2.25 A RESOLUTION 2005-10-27 2005-11-08 Kozbial, P.,Xu, Q.,Chiu, H.J.,McMullan, D.,Krishna, S.S.,Miller, M.D.,Abdubek, P.,Acosta, C.,Astakhova, T.,Axelrod, H.L.,Carlton, D.,Clayton, T.,Deller, M.,Duan, L.,Elias, Y.,Elsliger, M.A.,Feuerhelm, J.,Grzechnik, S.K.,Hale, J.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Koesema, E.,Kumar, A.,Marciano, D.,Morse, A.T.,Murphy, K.D.,Nigoghossian, E.,Okach, L.,Oommachen, S.,Reyes, R.,Rife, C.L.,Spraggon, G.,Trout, C.V.,van den Bedem, H.,Weekes, D.,White, A.,Wolf, G.,Zubieta, C.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A. Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold. Proteins 2008 71 1589 1596 2A66 16289203 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter 2005-07-01 2005-12-06 Solomon, I.H.,Hager, J.M.,Safi, R.,McDonnell, D.P.,Redinbo, M.R.,Ortlund, E.A. Crystal Structure of the Human LRH-1 DBD-DNA Complex Reveals Ftz-F1 Domain Positioning is Required for Receptor Activity. J.Mol.Biol. 2005 354 1091 1102 2BE3 Structure of a GTP Pyrophosphokinase Family Protein from Streptococcus pneumoniae 2005-10-21 2005-12-06 Cuff, M.E.,Hatzos, C.,Joachimiak, A. Structure of a GTP Pyrophosphokinase Family Protein from Streptococcus pneumoniae To be Published 0 0 0 0 2EWR Crystal structure of a putative nucleotidyltransferase (tm1012) from Thermotoga maritima at 1.60 A resolution 2005-11-05 2005-12-06 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (tm1012) from Thermotoga maritima at 1.60 A resolution To be published 0 0 0 0 2ETV Crystal structure of a putative fe(iii) abc transporter (tm0189) from thermotoga maritima msb8 at 1.70 A resolution 2005-10-27 2006-02-07 Joint Center for Structural Genomics (JCSG) Crystal structure of IRON(III) ABC transporter, periplasmic iron-binding protein, putative (tm0189) from THERMOTOGA MARITIMA at 1.70 A resolution To be published 0 0 0 0 2F4I Crystal structure of an ob-fold protein (tm0957) from thermotoga maritima msb8 at 1.90 A resolution 2005-11-23 2006-02-07 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (tm0957) from THERMOTOGA MARITIMA at 2.25 A resolution To be published 0 0 0 0 2FNA 19089981 Crystal structure of an archaeal aaa+ atpase (sso1545) from sulfolobus solfataricus p2 at 2.00 A resolution 2006-01-10 2006-02-07 Xu, Q.,Rife, C.L.,Carlton, D.,Miller, M.D.,Krishna, S.S.,Elsliger, M.A.,Abdubek, P.,Astakhova, T.,Chiu, H.J.,Clayton, T.,Duan, L.,Feuerhelm, J.,Grzechnik, S.K.,Hale, J.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kumar, A.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Okach, L.,Oommachen, S.,Paulsen, J.,Reyes, R.,van den Bedem, H.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A. Crystal structure of a novel archaeal AAA+ ATPase SSO1545 from Sulfolobus solfataricus. Proteins 2009 74 1041 1049 2FS3 17098191 Bacteriophage HK97 K169Y Head I 2006-01-20 2006-02-07 Gan, L.,Speir, J.A.,Conway, J.F.,Lander, G.,Cheng, N.,Firek, B.A.,Hendrix, R.W.,Duda, R.L.,Liljas, L.,Johnson, J.E. Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM. Structure 2006 14 1655 1665 2FSY 17098191 Bacteriophage HK97 Pepsin-treated Expansion Intermediate IV 2006-01-23 2006-02-07 Gan, L.,Speir, J.A.,Conway, J.F.,Lander, G.,Cheng, N.,Firek, B.A.,Hendrix, R.W.,Duda, R.L.,Liljas, L.,Johnson, J.E. Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM. Structure 2006 14 1655 1665 2FT1 17098191 Bacteriophage HK97 Head II 2006-01-23 2006-02-07 Gan, L.,Speir, J.A.,Conway, J.F.,Lander, G.,Cheng, N.,Firek, B.A.,Hendrix, R.W.,Duda, R.L.,Liljas, L.,Johnson, J.E. Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM. Structure 2006 14 1655 1665 2FVG Crystal structure of Endoglucanase (tm1049) from THERMOTOGA MARITIMA at 2.01 A resolution 2006-01-30 2006-03-07 Joint Center for Structural Genomics (JCSG) Crystal structure of Endoglucanase (tm1049) from THERMOTOGA MARITIMA at 2.01 A resolution To be published 0 0 0 0 2G5W 21915915 X-ray crystal structure of Arabidopsis thaliana 12-oxophytodienoate reductase isoform 3 (AtOPR3) in complex with 8-iso prostaglandin A1 and its cofactor, flavin mononucleotide. 2006-02-23 2006-04-04 Han, B.W.,Malone, T.E.,Kim, D.J.,Bingman, C.A.,Kim, H.J.,Fox, B.G.,Phillips, G.N. Crystal structure of Arabidopsis thaliana 12-oxophytodienoate reductase isoform 3 in complex with 8-iso prostaglandin A(1). Proteins 2011 79 3236 3241 2GCU 16929096 X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580 2006-03-14 2006-04-18 McCoy, J.G.,Bingman, C.A.,Bitto, E.,Holdorf, M.M.,Makaroff, C.A.,Phillips, G.N. Structure of an ETHE1-like protein from Arabidopsis thaliana. ACTA CRYSTALLOGR.,SECT.D 2006 62 964 970 2GVH Crystal structure of Acyl-CoA hydrolase (15159470) from AGROBACTERIUM TUMEFACIENS at 2.65 A resolution 2006-05-02 2006-05-30 Joint Center for Structural Genomics (JCSG) Crystal structure of Acyl-CoA hydrolase (15159470) from AGROBACTERIUM TUMEFACIENS at 2.65 A resolution To be published 0 0 0 0 2H1J 17099920 3.1 A X-ray structure of putative Oligoendopeptidase F: Crystals grown by microfluidic seeding 2006-05-16 2006-06-13 Gerdts, C.J.,Tereshko, V.,Yadav, M.K.,Dementieva, I.,Collart, F.,Joachimiak, A.,Stevens, R.C.,Kuhn, P.,Kossiakoff, A.,Ismagilov, R.F. Time-Controlled Microfluidic Seeding in nL-Volume Droplets To Separate Nucleation and Growth Stages of Protein Crystallization. Angew.Chem.Int.Ed.Engl. 2006 45 8156 8160 2H1N 17099920 3.0 A X-ray structure of putative oligoendopeptidase F: crystals grown by vapor diffusion technique 2006-05-16 2006-06-13 Gerdts, C.J.,Tereshko, V.,Yadav, M.K.,Dementieva, I.,Collart, F.,Joachimiak, A.,Stevens, R.C.,Kuhn, P.,Kossiakoff, A.,Ismagilov, R.F. Time-Controlled Microfluidic Seeding in nL-Volume Droplets To Separate Nucleation and Growth Stages of Protein Crystallization. Angew.Chem.Int.Ed.Engl. 2006 45 8156 8160 2GU2 17194761 Crystal Structure of an Aspartoacylase from Rattus norvegicus 2006-04-28 2006-06-20 Bitto, E.,Bingman, C.A.,Wesenberg, G.E.,McCoy, J.G.,Phillips, G.N. Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. Proc.Natl.Acad.Sci.Usa 2007 104 456 461 2H3B 16783373 Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1 2006-05-22 2006-06-20 Wang, T.,Zhang, X.,Bheda, P.,Revollo, J.R.,Imai, S.I.,Wolberger, C. Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme. Nat.Struct.Mol.Biol. 2006 13 661 662 2H3D 16783373 Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide 2006-05-22 2006-06-20 Wang, T.,Zhang, X.,Bheda, P.,Revollo, J.R.,Imai, S.I.,Wolberger, C. Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme. Nat.Struct.Mol.Biol. 2006 13 661 662 2H1S Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens 2006-05-16 2006-06-27 Bitto, E.,Wesenberg, G.E.,Phillips Jr., G.N.,Bingman, C.A.,Center for Eukaryotic Structural Genomics (CESG) Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens To be Published 0 0 0 0 2F6J 16728978 Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4me3 bound state 2005-11-29 2006-07-11 Li, H.,Ilin, S.,Wang, W.,Duncan, E.M.,Wysocka, J.,Allis, C.D.,Patel, D.J. Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature 2006 442 91 95 2HO4 Crystal Structure of Protein from Mouse Mm.236127 2006-07-13 2006-08-15 McCoy, J.G.,WESENBERG, G.E.,BITTO, E.,PHILLIPS JR., G.N.,BINGMAN, C.A. Crystal Structure of Protein from Mouse Mm.236127 To be published 0 0 0 0 2I0Z Crystal structure of a FAD binding protein from Bacillus cereus, a putative NAD(FAD)-utilizing dehydrogenases 2006-08-11 2006-08-22 Minasov, G.,Shuvalova, L.,Vorontsov, I.I.,Kiryukhina, O.,Abdullah, J.,Collart, F.R.,Joachimiak, A.,Anderson, W.F. Crystal structure of a FAD binding protein from Bacillus cereus, a putative NAD(FAD)-utilizing dehydrogenases To be Published 0 0 0 0 2HKO 16956976 Crystal structure of LSD1 2006-07-05 2006-08-29 Chen, Y.,Yang, Y.,Wang, F.,Wan, K.,Yamane, K.,Zhang, Y.,Lei, M. Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc.Natl.Acad.Sci.Usa 2006 103 13956 13961 2I5T 17932939 Crystal Structure of hypothetical protein LOC79017 from Homo sapiens 2006-08-25 2006-09-12 Bae, E.,Bingman, C.A.,Aceti, D.J.,Phillips Jr., G.N. Crystal structure of Homo sapiens protein LOC79017. Proteins 2008 70 588 591 2H7X 16969373 Pikromycin Thioesterase adduct with reduced triketide affinity label 2006-06-05 2006-09-19 Giraldes, J.W.,Akey, D.L.,Kittendorf, J.D.,Sherman, D.H.,Smith, J.S.,Fecik, R.A. Structural and Mechanistic Insights of Polyketide Macrolactonization from Polyketide-based Affinity Labels NAT.CHEM.BIOL. 2006 2 531 536 2H7Y 16969373 Pikromycin Thioesterase with covalent affinity label 2006-06-06 2006-09-19 Giraldes, J.W.,Akey, D.L.,Kittendorf, J.D.,Sherman, D.H.,Smith, J.S.,Fecik, R.A. Structural and Mechanistic Insights of Polyketide Macrolactonization from Polyketide-based Affinity Labels NAT.CHEM.BIOL. 2006 2 531 536 2HFJ 16969372 Pikromycin thioesterase with covalent pentaketide affinity label 2006-06-24 2006-09-19 Akey, D.L.,Kittendorf, J.D.,Giraldes, J.W.,Fecik, R.A.,Sherman, D.H.,Smith, J.L. Structural Basis for Macrolactonization by the Pikromycin Thioesterase NAT.CHEM.BIOL. 2006 2 537 542 2HFK 16969372 Pikromycin thioesterase in complex with product 10-deoxymethynolide 2006-06-24 2006-09-19 Akey, D.L.,Kittendorf, J.D.,Giraldes, J.W.,Fecik, R.A.,Sherman, D.H.,Smith, J.L. Structural Basis for Macrolactonization by the Pikromycin Thioesterase NAT.CHEM.BIOL. 2006 2 537 542 2I5N 17159147 1.96 A X-ray structure of photosynthetic reaction center from Rhodopseudomonas viridis:Crystals grown by microfluidic technique 2006-08-25 2006-09-19 Li, L.,Mustafi, D.,Fu, Q.,Tereshko, V.,Chen, D.L.,Tice, J.D.,Ismagilov, R.F. Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc.Natl.Acad.Sci.Usa 2006 103 19243 19248 2I8D Crystal structure of an uncharacterized conserved protein of COG5646 (ZP_00384875.1) from Lactobacillus casei ATCC 334 at 1.69 A resolution 2006-09-01 2006-09-19 Joint Center for Structural Genomics (JCSG) Crystal structure of an uncharacterized conserved protein of COG5646 (ZP_00384875.1) from Lactobacillus casei ATCC 334 at 1.69 A resolution To be published 0 0 0 0 2I9W Crystal structure of a sec-c motif containing protein (psyc_2064) from psychrobacter arcticus at 1.75 A resolution 2006-09-06 2006-09-19 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (YP_265345.1) from Psychrobacter Arcticum 273-4 at 1.75 A resolution To be published 0 0 0 0 2IA7 Crystal structure of putative tail lysozyme (NP_952040.1) from GEOBACTER SULFURREDUCENS at 1.44 A resolution 2006-09-07 2006-09-19 Joint Center for Structural Genomics (JCSG) Crystal structure of putative tail lysozyme (NP_952040.1) from GEOBACTER SULFURREDUCENS at 1.44 A resolution To be published 0 0 0 0 2ICG Crystal structure of a protein of unknown function (NP_472245.1) from Listeria innocua at 1.65 A resolution 2006-09-12 2006-09-26 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (NP_472245.1) from Listeria Innocua at 1.65 A resolution To be published 0 0 0 0 2GIT 16962135 Human Class I MHC HLA-A2 in complex with the modified HTLV-1 TAX (Y5K-4-[3-Indolyl]-butyric acid) peptide 2006-03-29 2006-10-03 Gagnon, S.J.,Borbulevych, O.Y.,Davis-Harrison, R.L.,Turner, R.V.,Damirjian, M.,Wojnarowicz, A.,Biddison, W.E.,Baker, B.M. T Cell Receptor Recognition via Cooperative Conformational Plasticity. J.Mol.Biol. 2006 363 228 243 2ICH 20944205 CRYSTAL STRUCTURE OF A PUTATIVE ATTH (NE1406) FROM NITROSOMONAS EUROPAEA AT 2.00 A RESOLUTION 2006-09-12 2006-10-03 Chiu, H.J.,Bakolitsa, C.,Skerra, A.,Lomize, A.,Carlton, D.,Miller, M.D.,Krishna, S.S.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Clayton, T.,Deller, M.C.,Duan, L.,Feuerhelm, J.,Grant, J.C.,Grzechnik, S.K.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Kumar, A.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Okach, L.,Paulsen, J.,Reyes, R.,Rife, C.L.,van den Bedem, H.,Weekes, D.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A. Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism. Acta Crystallogr.,Sect.F 2010 66 1153 1159 2IAY 20944212 Crystal structure of a duf1831 family protein (lp2179) from lactobacillus plantarum at 1.20 A resolution 2006-09-08 2006-10-10 Bakolitsa, C.,Kumar, A.,Carlton, D.,Miller, M.D.,Krishna, S.S.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Chiu, H.J.,Clayton, T.,Deller, M.C.,Duan, L.,Elsliger, M.A.,Feuerhelm, J.,Grzechnik, S.K.,Grant, J.C.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Okach, L.,Oommachen, S.,Paulsen, J.,Reyes, R.,Rife, C.L.,Tien, H.J.,Trout, C.V.,van den Bedem, H.,Weekes, D.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A. Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism. Acta Crystallogr.,Sect.F 2010 66 1205 1210 2IFU 17634982 Crystal Structure of a Gamma-SNAP from Danio rerio 2006-09-21 2006-10-10 Bitto, E.,Bingman, C.A.,Kondrashov, D.A.,McCoy, J.G.,Bannen, R.M.,Wesenberg, G.E.,Phillips, G.N. Structure and dynamics of gamma-SNAP: insight into flexibility of proteins from the SNAP family. Proteins 2008 70 93 104 2IFX Crystal structure of a putative 4-methylmuconolactone methylisomerase (YP_295714.1) from Ralstonia eutropha JMP134 at 2.00 A resolution 2006-09-21 2006-10-10 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (YP_295714.1) from Ralstonia Eutropha JMP134 at 2.00 A resolution To be published 0 0 0 0 2DTU 17098747 Crystal structure of the beta hairpin loop deletion variant of RB69 gp43 in complex with DNA containing an abasic site analog 2006-07-15 2006-12-05 Hogg, M.,Aller, P.,Konigsberg, W.,Wallace, S.S.,Doublie, S. Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family. J.Biol.Chem. 2007 282 1432 1444 2NUJ Crystal structure of thioesterase superfamily (YP_509914.1) from Jannaschia Sp. CCS1 at 2.00 A resolution 2006-11-09 2006-12-12 Joint Center for Structural Genomics (JCSG) Crystal structure of thioesterase superfamily (YP_509914.1) from Jannaschia Sp. CCS1 at 2.00 A resolution To be published 0 0 0 0 2NXF Crystal Structure of a dimetal phosphatase from Danio rerio LOC 393393 2006-11-17 2006-12-12 Bitto, E.,Wesenberg, G.E.,Phillips Jr., G.N.,McCoy, J.G.,Bingman, C.A. Crystal Structure of a dimetal phosphatase from Danio rerio LOC 393393 To be Published 0 0 0 0 2NYI 22528523 Crystal Structure of an Unknown Protein from Galdieria sulphuraria 2006-11-20 2006-12-12 Bitto, E.,Kim, D.J.,Bingman, C.A.,Kim, H.J.,Han, B.W.,Phillips, G.N. Crystal structure of tandem ACT domain-containing protein ACTP from Galdieria sulphuraria. Proteins 2012 80 2105 2109 2O08 CRYSTAL STRUCTURE OF A PUTATIVE HD SUPERFAMILY HYDROLASE (BH1327) FROM BACILLUS HALODURANS AT 1.90 A RESOLUTION 2006-11-27 2006-12-19 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (NP_242193.1) from Bacillus halodurans at 1.90 A resolution To be published 0 0 0 0 2O2G Crystal structure of Dienelactone hydrolase (YP_324580.1) from Anabaena variabilis ATCC 29413 at 1.92 A resolution 2006-11-29 2006-12-19 Joint Center for Structural Genomics (JCSG) Crystal structure of Dienelactone hydrolase (YP_324580.1) from Anabaena variabilis ATCC 29413 at 1.92 A resolution To be published 0 0 0 0 2O3L Crystal structure of a duf1048 protein with a left-handed superhelix fold (bce_3448) from bacillus cereus atcc 10987 at 2.05 A resolution 2006-12-01 2006-12-19 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (NP_979748.1) from Bacillus cereus ATCC 10987 at 2.05 A resolution To be published 0 0 0 0 2O55 Crystal Structure of a putative glycerophosphodiester phosphodiesterase from Galdieria sulphuraria 2006-12-05 2006-12-19 Mccoy, J.G.,Wesenberg, G.E.,Phillips Jr., G.N.,Bitto, E.,Bingman, C.A. Crystal Structure of a putative glycerophosphodiester phosphodiesterase from Galdieria sulphuraria To be Published 0 0 0 0 2O57 Crystal Structure of a putative sarcosine dimethylglycine methyltransferase from Galdieria sulphuraria 2006-12-05 2006-12-19 Mccoy, J.G.,Wesenberg, G.E.,Phillips Jr., G.N.,Bitto, E.,Bingman, C.A. Crystal Structure of a putative sarcosine dimethylglycine methyltransferase from Galdieria sulphuraria To be Published 0 0 0 0 2O5R Crystal structure of Glutamyl-tRNA synthetase 1 (EC 6.1.1.17) (Glutamate-tRNA ligase 1) (GluRS 1) (TM1351) from Thermotoga maritima at 2.5 A resolution 2006-12-06 2006-12-19 Joint Center for Structural Genomics (JCSG) Crystal structure of Glutamyl-tRNA synthetase 1 (EC 6.1.1.17) (Glutamate-tRNA ligase 1) (GluRS 1) (TM1351) from Thermotoga maritima at 2.5 A resolution To be published 0 0 0 0 2NZ9 17173035 Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2 2006-11-22 2006-12-26 Garcia-Rodriguez, C.,Levy, R.,Arndt, J.W.,Forsyth, C.M.,Razai, A.,Lou, J.,Geren, I.,Stevens, R.C.,Marks, J.D. Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin. Nat.Biotechnol. 2007 25 107 116 2O4T CRYSTAL STRUCTURE OF a protein of the DUF1048 family with a left-handed superhelix fold (BH3976) FROM BACILLUS HALODURANS AT 1.95 A RESOLUTION 2006-12-04 2006-12-26 Joint Center for Structural Genomics (JCSG) Crystal structure of BH3976 (10176601) from Bacillus halodurans at 1.95 A resolution To be published 0 0 0 0 2O8Q CRYSTAL STRUCTURE OF A PROTEIN WITH A CUPIN-LIKE FOLD AND UNKNOWN FUNCTION (BXE_C0505) FROM BURKHOLDERIA XENOVORANS LB400 AT 1.55 A RESOLUTION 2006-12-12 2006-12-26 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (YP_555756.1) from Burkholderia xenovorans LB400 at 1.55 A resolution To be published 0 0 0 0 2DY4 17210917 Crystal structure of RB69 GP43 in complex with DNA containing Thymine Glycol 2006-09-06 2007-01-09 Aller, P.,Rould, M.A.,Hogg, M.,Wallace, S.S.,Doublie, S. A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol. Proc.Natl.Acad.Sci.USA 2007 104 814 818 2OC6 Crystal structure of a protein from the duf1801 family (ydhg, bsu05750) from bacillus subtilis at 1.75 A resolution 2006-12-20 2007-01-16 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (NP_388456.1) from Bacillus subtilis at 1.75 A resolution To be published 0 0 0 0 2O1Q CRYSTAL STRUCTURE OF A PUTATIVE ACETYLACETONE DIOXYGENASE (MPE_A3659) FROM METHYLIBIUM PETROLEIPHILUM PM1 AT 1.50 A RESOLUTION 2006-11-29 2007-01-23 Joint Center for Structural Genomics (JCSG) Crystal structure of putative acetyl/propionyl-CoA carboxylase, alpha subunit (ZP_00243239.1) from Rubrivivax gelatinosus PM1 (Methylobium petroleophilum PM1) at 1.50 A resolution To be published 0 0 0 0 2OP5 CRYSTAL STRUCTURE OF A DIMERIC FERREDOXIN-LIKE PROTEIN (JCVI_PEP_1096672785533) FROM UNCULTURED MARINE ORGANISM AT 2.20 A RESOLUTION 2007-01-26 2007-02-06 Joint Center for Structural Genomics (JCSG) Crystal structure of hypothetical protein (JCVI_PEP_1096672785533) from an environmental metagenome (unidentified marine microbe), Sorcerer II Global Ocean Sampling experiment at 2.20 A resolution To be published 0 0 0 0 2IBL 17222867 Crystal structure of a helper molecule (HT-mf-thromb) based on mini-fibritin (mf) crystal structure (pdb:1OX3). 2006-09-11 2007-02-27 Boudko, S.P.,Kuhn, R.J.,Rossmann, M.G. The Coiled-coil Domain Structure of the Sin Nombre Virus Nucleocapsid Protein. J.Mol.Biol. 2007 366 1538 1544 2IC6 17222867 The Coiled-coil Domain (residues 1-75) Structure of the Sin Nombre Virus Nucleocapsid Protein 2006-09-12 2007-02-27 Boudko, S.P.,Kuhn, R.J.,Rossmann, M.G. The Coiled-coil Domain Structure of the Sin Nombre Virus Nucleocapsid Protein. J.Mol.Biol. 2007 366 1538 1544 2O9Z 17876823 Crystal Structure of RebH, a FAD-dependent halogenase from Lechevalieria aerocolonigenes, the Apo form 2006-12-14 2007-04-10 Bitto, E.,Huang, Y.,Bingman, C.A.,Singh, S.,Thorson, J.S.,Phillips Jr., G.N. The structure of flavin-dependent tryptophan 7-halogenase RebH. Proteins 2008 70 289 293 2OA1 17876823 Crystal Structure of RebH, a FAD-dependent halogenase from Lechevalieria aerocolonigenes, the L-Tryptophan with FAD complex 2006-12-14 2007-04-10 Bitto, E.,Huang, Y.,Bingman, C.A.,Singh, S.,Thorson, J.S.,Phillips Jr., G.N. The structure of flavin-dependent tryptophan 7-halogenase RebH. Proteins 2008 70 289 293 2P82 Cysteine protease ATG4A 2007-03-21 2007-04-10 Walker, J.R.,Davis, T.,Mujib, S.,Butler-Cole, C.,Finerty Jr., P.J.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. Human cysteine protease ATG4A To be Published 0 0 0 0 2HRQ 17407327 Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD) 2006-07-20 2007-05-01 Fleming, C.D.,Edwards, C.C.,Kirby, S.D.,Maxwell, D.M.,Potter, P.M.,Cerasoli, D.M.,Redinbo, M.R. Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun. Biochemistry 2007 46 5063 5071 2NTF 17400249 Crystal Structure of a Quorum-Quenching Antibody in Complex with an N-Acyl-L-Homoserine Lactone Analog 2006-11-07 2007-05-08 Debler, E.W.,Kaufmann, G.F.,Kirchdoerfer, R.N.,Mee, J.M.,Janda, K.D.,Wilson, I.A. Crystal Structures of a Quorum-quenching Antibody. J.Mol.Biol. 2007 368 1392 1402 2POK Crystal structure of a M20 family metallo peptidase from Streptococcus pneumoniae 2007-04-26 2007-05-08 Minasov, G.,Shuvalova, L.,Brunzelle, J.S.,Vorontsov, I.I.,Kiryukhina, O.,Collart, F.R.,Joachimiak, A.,Anderson, W.F. Crystal structure of a M20 family metallo peptidase from Streptococcus pneumoniae. TO BE PUBLISHED 0 0 0 0 2PR1 Crystal structure of the Bacillus subtilis N-acetyltransferase YlbP protein in complex with Coenzyme-A 2007-05-03 2007-05-15 Minasov, G.,Shuvalova, L.,Kiryukhina, O.,Vorontsov, I.I.,Collart, F.R.,Joachimiak, A.,Anderson, W.F. Crystal structure of the Bacillus subtilis N-acetyltransferase YlbP protein in complex with Coenzyme-A. To be Published 0 0 0 0 2PFT 17583731 The Crystal Structure of Mouse Exo70 Reveals Unique Features of the Mammalian Exocyst 2007-04-05 2007-05-22 Moore, B.A.,Robinson, H.H.,Xu, Z. The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst. J.Mol.Biol. 2007 371 410 421 2PXX 19089949 Human putative methyltransferase MGC2408 2007-05-14 2007-05-22 Tempel, W.,Wu, H.,Dombrovsky, L.,Zeng, H.,Loppnau, P.,Zhu, H.,Plotnikov, A.N.,Bochkarev, A. An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene. Proteins 2009 74 789 793 2PRS 18027003 Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli 2007-05-04 2007-06-05 Yatsunyk, L.A.,Easton, J.A.,Kim, L.R.,Sugarbaker, S.A.,Bennett, B.,Breece, R.M.,Vorontsov, I.I.,Tierney, D.L.,Crowder, M.W.,Rosenzweig, A.C. Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. J.Biol.Inorg.Chem. 2008 13 271 288 2PS0 18027003 Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli 2007-05-04 2007-06-05 Yatsunyk, L.A.,Easton, J.A.,Kim, L.R.,Sugarbaker, S.A.,Bennett, B.,Breece, R.M.,Vorontsov, I.I.,Tierney, D.L.,Crowder, M.W.,Rosenzweig, A.C. Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. J.Biol.Inorg.Chem. 2008 13 271 288 2PS3 18027003 Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli 2007-05-04 2007-06-05 Yatsunyk, L.A.,Easton, J.A.,Kim, L.R.,Sugarbaker, S.A.,Bennett, B.,Breece, R.M.,Vorontsov, I.I.,Tierney, D.L.,Crowder, M.W.,Rosenzweig, A.C. Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. J.Biol.Inorg.Chem. 2008 13 271 288 2PS9 18027003 Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli 2007-05-04 2007-06-05 Yatsunyk, L.A.,Easton, J.A.,Kim, L.R.,Sugarbaker, S.A.,Bennett, B.,Breece, R.M.,Vorontsov, I.I.,Tierney, D.L.,Crowder, M.W.,Rosenzweig, A.C. Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. J.Biol.Inorg.Chem. 2008 13 271 288 2Q2F Structure of the human Selenoprotein S (VCP-interacting membrane protein) 2007-05-28 2007-06-05 Walker, J.R.,Paramanathan, R.,Butler-Cole, C.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. Human Selenoprotein S (VCP-interacting membrane protein). To be Published 0 0 0 0 2Q32 17965015 Crystal structure of human heme oxygenase-2 C127A (HO-2) 2007-05-29 2007-06-05 Bianchetti, C.M.,Yi, L.,Ragsdale, S.W.,Phillips Jr., G.N. Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2. J.Biol.Chem. 2007 282 37624 37631 2GT9 17719062 Human Class I MHC HLA-A2 in complex with the decameric Melan-A/MART-1(26-35) peptide 2006-04-27 2007-06-12 Borbulevych, O.Y.,Insaidoo, F.K.,Baxter, T.K.,Powell, D.J.,Johnson, L.A.,Restifo, N.P.,Baker, B.M. Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol. 2007 372 1123 1136 2GTW 17719062 Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution 2006-04-28 2007-06-12 Borbulevych, O.Y.,Insaidoo, F.K.,Baxter, T.K.,Powell, D.J.,Johnson, L.A.,Restifo, N.P.,Baker, B.M. Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol. 2007 372 1123 1136 2GTZ 17719062 Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A28L substitution 2006-04-28 2007-06-12 Borbulevych, O.Y.,Insaidoo, F.K.,Baxter, T.K.,Powell, D.J.,Johnson, L.A.,Restifo, N.P.,Baker, B.M. Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol. 2007 372 1123 1136 2GUO 17719062 Human Class I MHC HLA-A2 in complex with the native nonameric Melan-A/MART-1(27-35) peptide 2006-05-01 2007-06-12 Borbulevych, O.Y.,Insaidoo, F.K.,Baxter, T.K.,Powell, D.J.,Johnson, L.A.,Restifo, N.P.,Baker, B.M. Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition J.Mol.Biol. 2007 372 1123 1136 2Q14 Crystal structure of Phosphohydrolase (BT4208) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution 2007-05-23 2007-06-12 Joint Center for Structural Genomics (JCSG) Crystal structure of Phosphohydrolase (BT4208) from Bacteroides thetaiotaomicron VPI-5482 at 2.20 A resolution To be published 0 0 0 0 2Q2G Crystal structure of dimerization domain of HSP40 from Cryptosporidium parvum, cgd2_1800 2007-05-28 2007-06-12 Wernimont, A.K.,Lew, J.,Lin, L.,Hassanali, A.,Kozieradzki, I.,Wasney, G.,Vedadi, M.,Walker, J.R.,Zhao, Y.,Schapira, M.,Bochkarev, A.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Hui, R.,Brokx, S. Crystal structure of dimerization domain of HSP40 from Cryptosporidium parvum, cgd2_1800. To be Published 0 0 0 0 2HU9 17609202 X-ray structure of the Archaeoglobus fulgidus CopZ N-terminal Domain 2006-07-26 2007-07-03 Sazinsky, M.H.,LeMoine, B.,Orofino, M.,Davydov, R.,Bencze, K.Z.,Stemmler, T.L.,Hoffman, B.M.,Arguello, J.M.,Rosenzweig, A.C. Characterization and structure of a Zn2+ and [2Fe-2S]-containing copper chaperone from Archaeoglobus fulgidus. J.Biol.Chem. 2007 282 25950 25959 2Q8C 17589523 Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate 2007-06-10 2007-07-03 Couture, J.F.,Collazo, E.,Ortiz-Tello, P.A.,Brunzelle, J.S.,Trievel, R.C. Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol. 2007 14 689 695 2Q8D 17589523 Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate 2007-06-10 2007-07-03 Couture, J.F.,Collazo, E.,Ortiz-Tello, P.A.,Brunzelle, J.S.,Trievel, R.C. Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol. 2007 14 689 695 2Q8E 17589523 Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase 2007-06-10 2007-07-03 Couture, J.F.,Collazo, E.,Ortiz-Tello, P.A.,Brunzelle, J.S.,Trievel, R.C. Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol. 2007 14 689 695 2QT1 17914902 Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside 2007-07-31 2007-08-14 Tempel, W.,Rabeh, W.M.,Bogan, K.L.,Belenky, P.,Wojcik, M.,Seidle, H.F.,Nedyalkova, L.,Yang, T.,Sauve, A.A.,Park, H.W.,Brenner, C. Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+). Plos Biol. 2007 5 0 0 2P73 17850743 crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1 2007-03-19 2007-08-21 Zhang, Y.,Xiang, Y.,Van Etten, J.L.,Rossmann, M.G. Structure and function of a chlorella virus-encoded glycosyltransferase. Structure 2007 15 1031 1039 2P4A 17888451 X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A 2007-03-11 2007-08-28 Koide, A.,Tereshko, V.,Uysal, S.,Margalef, K.,Kossiakoff, A.A.,Koide, S. Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J.Mol.Biol. 2007 373 941 953 2OZ0 17563122 Mechanistic and Structural Studies of H373Q Flavocytochrome b2: Effects of Mutating the Active Site Base 2007-02-23 2007-09-11 Tsai, C.L.,Gokulan, K.,Sobrado, P.,Sacchettini, J.C.,Fitzpatrick, P.F. Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base. Biochemistry 2007 46 7844 7851 2Q7A 17920629 Crystal structure of the cell surface heme transfer protein Shp 2007-06-06 2007-09-18 Aranda IV, R.,Worley, C.E.,Liu, M.,Bitto, E.,Cates, M.S.,Olson, J.S.,Lei, B.,Phillips Jr., G.N. Bis-methionyl coordination in the crystal structure of the heme-binding domain of the streptococcal cell surface protein Shp. J.Mol.Biol. 2007 374 374 383 2R7G 17974914 Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain 2007-09-07 2007-10-02 Liu, X.,Marmorstein, R. Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor Genes Dev. 2007 21 2711 2716 2P7T Crystal Structure of KcsA mutant 2007-03-20 2007-10-09 Cordero-Morales, J.F.,Vishwanath, J.,Lewis, A.,Vasquez, V.,Cortes, D.M.,Roux, B.,Perozo, E. Crystal Structure of KcsA mutant To be Published 0 0 0 0 2Q73 17892463 Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P41212) 2007-06-05 2007-10-09 Robinson, A.,Guilfoyle, A.P.,Harrop, S.J.,Boucher, Y.,Stokes, H.W.,Curmi, P.M.,Mabbutt, B.C. A putative house-cleaning enzyme encoded within an integron array: 1.8 A crystal structure defines a new MazG subtype. Mol.Microbiol. 2007 66 610 621 2Q9L 17892463 Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P43212) 2007-06-13 2007-10-09 Robinson, A.,Guilfoyle, A.P.,Harrop, S.J.,Boucher, Y.,Stokes, H.W.,Curmi, P.M.,Mabbutt, B.C. A putative house-cleaning enzyme encoded within an integron array: 1.8 A crystal structure defines a new MazG subtype. Mol.Microbiol. 2007 66 610 621 2QP9 17949747 Crystal Structure of S.cerevisiae Vps4 2007-07-23 2007-10-09 Xiao, J.,Xia, H.,Yoshino-Koh, K.,Zhou, J.,Xu, Z. Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J.Mol.Biol. 2007 374 655 670 2QP9 17949747 Crystal Structure of S.cerevisiae Vps4 2007-07-23 2007-10-09 Xiao, J.,Xia, H.,Yoshino-Koh, K.,Zhou, J.,Xu, Z. Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J.Mol.Biol. 2007 374 655 670 2RE2 CRYSTAL STRUCTURE OF A PUTATIVE IRON-MOLYBDENUM COFACTOR (FEMO-CO) DINITROGENASE (TA1041M) FROM THERMOPLASMA ACIDOPHILUM DSM 1728 AT 1.30 A RESOLUTION 2007-09-25 2007-10-09 Joint Center for Structural Genomics (JCSG) Crystal structure of protein of unknown function (NP_394501.1) from Thermoplasma acidophilum at 1.30 A resolution To be published 0 0 0 0 2RE7 Crystal structure of a pyridoxamine 5'-phosphate oxidase related protein (psyc_0186) from psychrobacter arcticus 273-4 at 2.50 A resolution 2007-09-25 2007-10-09 Joint Center for Structural Genomics (JCSG) Crystal structure of General Stress Protein COG3871 (YP_263493.1) from Psychrobacter arcticus 273-4 at 2.50 A resolution To be published 0 0 0 0 2RFF Crystal structure of a putative nucleotidyltransferase (NP_343093.1) from Sulfolobus solfataricus at 1.40 A resolution 2007-09-28 2007-10-16 Joint Center for Structural Genomics (JCSG) Crystal structure of a putative nucleotidyltransferase (NP_343093.1) from Sulfolobus solfataricus at 1.40 A resolution To be published 0 0 0 0 2RH0 Crystal structure of NudC domain-containing protein 2 (13542905) from Mus musculus at 1.95 A resolution 2007-10-05 2007-10-16 Joint Center for Structural Genomics (JCSG) Crystal structure of NudC domain-containing protein 2 (13542905) from Mus musculus at 1.95 A resolution To be published 0 0 0 0 2OYQ 17718515 Crystal structure of RB69 gp43 in complex with DNA with 5-NIMP opposite an abasic site analog 2007-02-22 2007-10-23 Zahn, K.E.,Belrhali, H.,Wallace, S.S.,Doublie, S. Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry 2007 46 10551 10561 2P5G 17718515 Crystal structure of RB69 gp43 in complex with DNA with dAMP opposite an abasic site analog in a 21mer template 2007-03-15 2007-10-23 Zahn, K.E.,Belrhali, H.,Wallace, S.S.,Doublie, S. Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry 2007 46 10551 10561 2RIJ Crystal structure of a putative 2,3,4,5-tetrahydropyridine-2-carboxylate n-succinyltransferase (cj1605c, dapd) from campylobacter jejuni at 1.90 A resolution 2007-10-11 2007-10-23 Joint Center for Structural Genomics (JCSG) Crystal structure of Putative 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (NP_282733.1) from Campylobacter jejuni at 1.90 A resolution To be published 0 0 0 0 2NUI 17610259 X-ray Structure of synthetic [D83A]RNase A 2006-11-09 2007-10-30 Boerema, D.J.,Tereshko, V.A.,Kent, S.B. Total synthesis by modern chemical ligation methods and high resolution (1.1 A) X-ray structure of ribonuclease A Biopolymers 2008 90 278 286 2QQA 17902703 Crystal Structure of DtxR(E9A C102D) Complexed with Nickel(II) 2007-07-26 2007-10-30 D'Aquino, J.A.,Lattimer, J.R.,Denninger, A.,D'Aquino, K.E.,Ringe, D. Role of the N-Terminal Helix in the Metal Ion-Induced Activation of the Diphtheria Toxin Repressor DtxR. Biochemistry 2007 46 11761 11770 2QBX 17897949 EphB2/SNEW Antagonistic Peptide Complex 2007-06-18 2007-11-06 Chrencik, J.E.,Brooun, A.,Recht, M.I.,Nicola, G.,Davis, L.K.,Abagyan, R.,Widmer, H.,Pasquale, E.B.,Kuhn, P. Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J.Biol.Chem. 2007 282 36505 36513 3B5Q Crystal structure of a putative sulfatase (NP_810509.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.40 A resolution 2007-10-26 2007-11-13 Joint Center for Structural Genomics (JCSG) Crystal structure of a putative sulfatase (NP_810509.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.40 A resolution To be published 0 0 0 0 2RHM Crystal structure of a putative kinase (caur_3907) from chloroflexus aurantiacus j-10-fl at 1.70 A resolution 2007-10-09 2007-11-20 Joint Center for Structural Genomics (JCSG) Crystal structure of putative kinase (ZP_00765535.1) from Chloroflexus aurantiacus J-10-fl at 1.70 A resolution To be published 0 0 0 0 2RHM Crystal structure of a putative kinase (caur_3907) from chloroflexus aurantiacus j-10-fl at 1.70 A resolution 2007-10-09 2007-11-20 Joint Center for Structural Genomics (JCSG) Crystal structure of putative kinase (ZP_00765535.1) from Chloroflexus aurantiacus J-10-fl at 1.70 A resolution To be published 0 0 0 0 2R6G 18033289 The Crystal Structure of the E. coli Maltose Transporter 2007-09-05 2007-11-27 Oldham, M.L.,Khare, D.,Quiocho, F.A.,Davidson, A.L.,Chen, J. Crystal structure of a catalytic intermediate of the maltose transporter. Nature 2007 450 515 521 3BCW Crystal structure of a duf861 family protein with a rmlc-like cupin fold (bb1179) from bordetella bronchiseptica rb50 at 1.60 A resolution 2007-11-13 2007-11-27 Joint Center for Structural Genomics (JCSG) Crystal structure of domain of unknown function with a RmlC-like cupin fold (NP_887725.1) from Bordetella bronchiseptica at 1.60 A resolution To be published 0 0 0 0 3BDI Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum at 1.45 A resolution 2007-11-14 2007-11-27 Joint Center for Structural Genomics (JCSG) Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum at 1.45 A resolution To be published 0 0 0 0 3BDV Crystal structure of a putative yden-like hydrolase (eca3091) from pectobacterium atrosepticum scri1043 at 1.66 A resolution 2007-11-15 2007-11-27 Joint Center for Structural Genomics (JCSG) Crystal structure of YdeN-like protein of unknown function (DUF1234) (YP_051181.1) from Erwinia carotovora subsp. atroseptica SCRI1043 at 1.66 A resolution To be published 0 0 0 0 2R8S 18162543 High resolution structure of a specific synthetic FAB bound to P4-P6 RNA ribozyme domain 2007-09-11 2007-12-04 Ye, J.D.,Tereshko, V.,Frederiksen, J.K.,Koide, A.,Fellouse, F.A.,Sidhu, S.S.,Koide, S.,Kossiakoff, A.A.,Piccirilli, J.A. Synthetic antibodies for specific recognition and crystallization of structured RNA Proc.Natl.Acad.Sci.Usa 2008 105 82 87 3BEM Crystal structure of putative nitroreductase ydfN (2632848) from Bacillus subtilis at 1.65 A resolution 2007-11-19 2007-12-04 Joint Center for Structural Genomics (JCSG) Crystal structure of putative nitroreductase ydfN (2632848) from Bacillus subtilis at 1.65 A resolution To be published 0 0 0 0 3BF5 Crystal structure of putative ribokinase (10640157) from Thermoplasma acidophilum at 1.91 A resolution 2007-11-20 2007-12-04 Joint Center for Structural Genomics (JCSG) Crystal structure of putative ribokinase (10640157) from Thermoplasma acidophilum at 1.91 A resolution To be published 0 0 0 0 3BFM Crystal structure of a biotin protein ligase-like protein of unknown function (tm1040_0394) from silicibacter sp. tm1040 at 1.70 A resolution 2007-11-21 2007-12-04 Joint Center for Structural Genomics (JCSG) Crystal structure of biotin protein ligase-like protein of unknown function (YP_612389.1) from Silicibacter sp. TM1040 at 1.70 A resolution To be published 0 0 0 0 2OL8 17985889 The crystal structure of OspA mutant 2007-01-18 2007-12-11 Makabe, K.,Yan, S.,Tereshko, V.,Gawlak, G.,Koide, S. beta-Strand Flipping and Slipping Triggered by Turn Replacement Reveal the Opportunistic Nature of beta-Strand Pairing J.Am.Chem.Soc. 2007 129 14661 14669 2QR7 18084304 2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative 2007-07-27 2007-12-11 Malakhova, M.,Tereshko, V.,Lee, S.Y.,Yao, K.,Cho, Y.-Y.,Bode, A.,Dong, Z. Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2. Nat.Struct.Mol.Biol. 2008 15 112 113 2QYU 18066077 Crystal structure of Salmonella effector protein SopA 2007-08-15 2007-12-11 Diao, J.,Zhang, Y.,Huibregtse, J.M.,Zhou, D.,Chen, J. Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nat.Struct.Mol.Biol. 2008 15 65 70 2QZA 18066077 Crystal structure of Salmonella effector protein SopA 2007-08-16 2007-12-11 Diao, J.,Zhang, Y.,Huibregtse, J.M.,Zhou, D.,Chen, J. Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nat.Struct.Mol.Biol. 2008 15 65 70 3BHQ CRYSTAL STRUCTURE OF A PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR (MLR_4833) FROM MESORHIZOBIUM LOTI MAFF303099 AT 1.54 A RESOLUTION 2007-11-28 2007-12-11 Joint Center for Structural Genomics (JCSG) Crystal structure of TetR-family transcriptional regulator (NP_105615.1) from Mesorhizobium loti at 1.54 A resolution To be published 0 0 0 0 3BJA Crystal structure of putative MarR-like transcription regulator (NP_978771.1) from Bacillus cereus ATCC 10987 at 2.38 A resolution 2007-12-03 2007-12-11 Joint Center for Structural Genomics (JCSG) Crystal structure of putative MarR-like transcription regulator (NP_978771.1) from Bacillus cereus ATCC 10987 at 2.38 A resolution To be published 0 0 0 0 3BJQ CRYSTAL STRUCTURE OF A PHAGE-RELATED PROTEIN (BB3626) FROM BORDETELLA BRONCHISEPTICA RB50 AT 2.05 A RESOLUTION 2007-12-04 2007-12-18 Joint Center for Structural Genomics (JCSG) Crystal structure of phage-related protein (NP_890161.1) from Bordetella bronchiseptica at 2.05 A resolution To be published 0 0 0 0 3BJR Crystal structure of a putative carboxylesterase (lp_1002) from lactobacillus plantarum wcfs1 at 2.09 A resolution 2007-12-04 2007-12-18 Joint Center for Structural Genomics (JCSG) Crystal structure of putative carboxylesterase (NP_784706.1) from Lactobacillus plantarum at 2.09 A resolution To be published 0 0 0 0 3BLN Crystal structure of acetyltransferase GNAT family (NP_981174.1) from Bacillus cereus ATCC 10987 at 1.31 A resolution 2007-12-11 2007-12-18 Joint Center for Structural Genomics (JCSG) Crystal structure of acetyltransferase GNAT family (NP_981174.1) from Bacillus cereus ATCC 10987 at 1.31 A resolution To be published 0 0 0 0 2I5V 18367205 Crystal structure of OspA mutant 2006-08-25 2007-12-25 Makabe, K.,Biancalana, M.,Yan, S.,Tereshko, V.,Gawlak, G.,Miller-Auer, H.,Meredith, S.C.,Koide, S. High-Resolution Structure of a Self-Assembly-Competent Form of a Hydrophobic Peptide Captured in a Soluble β-Sheet Scaffold. J.Mol.Biol. 2008 378 459 467 2R29 18264114 Neutralization of dengue virus by a serotype cross-reactive antibody elucidated by cryoelectron microscopy and x-ray crystallography 2007-08-24 2007-12-25 Lok, S.M.,Kostyuchenko, V.,Nybakken, G.E.,Holdaway, H.A.,Battisti, A.J.,Sukupolvi-Petty, S.,Sedlak, D.,Fremont, D.H.,Chipman, P.R.,Roehrig, J.T.,Diamond, M.S.,Kuhn, R.J.,Rossmann, M.G. Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nat.Struct.Mol.Biol. 2008 15 312 317 2R69 18264114 Crystal structure of Fab 1A1D-2 complexed with E-DIII of Dengue virus at 3.8 angstrom resolution 2007-09-05 2007-12-25 Lok, S.M.,Kostyuchenko, V.,Nybakken, G.E.,Holdaway, H.A.,Battisti, A.J.,Sukupolvi-Petty, S.,Sedlak, D.,Fremont, D.H.,Chipman, P.R.,Roehrig, J.T.,Diamond, M.S.,Kuhn, R.J.,Rossmann, M.G. Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nat.Struct.Mol.Biol. 2008 15 312 317 3BN8 Crystal structure of a putative sterol carrier protein type 2 (af1534) from archaeoglobus fulgidus dsm 4304 at 2.11 A resolution 2007-12-13 2007-12-25 Joint Center for Structural Genomics (JCSG) Crystal structure of putative sterol carrier protein 2 (2649030) from Archaeoglobus fulgidus at 2.11 A resolution To be published 0 0 0 0 3BO9 Crystal structure of putative nitroalkan dioxygenase (TM0800) from Thermotoga maritima at 2.71 A resolution 2007-12-17 2007-12-25 Joint Center for Structural Genomics (JCSG) Crystal structure of putative nitroalkan dioxygenase (TM0800) from Thermotoga maritima at 2.71 A resolution To be published 0 0 0 0 2RKJ 18172503 Cocrystal structure of a tyrosyl-tRNA synthetase splicing factor with a group I intron RNA 2007-10-16 2008-01-08 Paukstelis, P.J.,Chen, J.H.,Chase, E.,Lambowitz, A.M.,Golden, B.L. Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA. Nature 2008 451 94 97 3BOM Crystal structure of trout hemoglobin at 1.35 Angstrom resolution 2007-12-17 2008-01-08 Aranda IV, R.,Bingman, C.A.,Bitto, E.,Wesenberg, G.E.,Richards, M.,Phillips Jr., G.N. Trout Hemoglobin Crystal Structure at 1.35 Angstroms Resolution. To be Published 0 0 0 0 3BVO 18713742 Crystal structure of human co-chaperone protein HscB 2008-01-07 2008-01-15 Bitto, E.,Bingman, C.A.,Bittova, L.,Kondrashov, D.A.,Bannen, R.M.,Fox, B.G.,Markley, J.L.,Phillips, G.N. Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain. J.Biol.Chem. 2008 283 30184 30192 2RKL 18194651 Crystal Structure of S.cerevisiae Vta1 C-terminal domain 2007-10-16 2008-01-22 Xiao, J.,Xia, H.,Zhou, J.,Azmi, I.F.,Davies, B.A.,Katzmann, D.J.,Xu, Z. Structural basis of vta1 function in the multivesicular body sorting pathway. Dev.Cell 2008 14 37 49 3BWW Crystal structure of a duf692 family protein (hs_1138) from haemophilus somnus 129pt at 2.20 A resolution 2008-01-10 2008-01-22 Joint Center for Structural Genomics (JCSG) Crystal structure of protein of unknown function (DUF692/COG3220) (YP_719350.1) from Haemophilus somnus 129PT at 2.20 A resolution To be published 0 0 0 0 3BY7 19173316 CRYSTAL STRUCTURE OF A PROTEIN STRUCTURALLY SIMILAR TO SM/LSM-LIKE RNA-BINDING PROTEINS (JCVI_PEP_1096686650277) FROM UNCULTURED MARINE ORGANISM AT 2.60 A RESOLUTION 2008-01-15 2008-01-29 Das, D.,Kozbial, P.,Axelrod, H.L.,Miller, M.D.,McMullan, D.,Krishna, S.S.,Abdubek, P.,Acosta, C.,Astakhova, T.,Burra, P.,Carlton, D.,Chen, C.,Chiu, H.J.,Clayton, T.,Deller, M.C.,Duan, L.,Elias, Y.,Elsliger, M.A.,Ernst, D.,Farr, C.,Feuerhelm, J.,Grzechnik, A.,Grzechnik, S.K.,Hale, J.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Johnson, H.A.,Klock, H.E.,Knuth, M.W.,Kumar, A.,Marciano, D.,Morse, A.T.,Murphy, K.D.,Nigoghossian, E.,Nopakun, A.,Okach, L.,Oommachen, S.,Paulsen, J.,Puckett, C.,Reyes, R.,Rife, C.L.,Sefcovic, N.,Sudek, S.,Tien, H.,Trame, C.,Trout, C.V.,van den Bedem, H.,Weekes, D.,White, A.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A. Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 A resolution. Proteins 2009 75 296 307 3BZB Crystal structure of uncharacterized protein CMQ451C from the primitive red alga Cyanidioschyzon merolae 2008-01-17 2008-01-29 McCoy, J.G.,Bitto, E.,Bingman, C.A.,Wesenberg, G.E.,Phillips Jr., G.N. Crystal structure of uncharacterized protein CMQ451C from the primitive red alga Cyanidioschyzon merolae. To be Published 0 0 0 0 2OCI 18256025 Crystal structure of valacyclovir hydrolase complexed with a product analogue 2006-12-20 2008-02-05 Lai, L.,Xu, Z.,Zhou, J.,Lee, K.D.,Amidon, G.L. Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. J.Biol.Chem. 2008 283 9318 9327 3C1A Crystal structure of a putative oxidoreductase (ZP_00056571.1) from Magnetospirillum magnetotacticum MS-1 at 1.85 A resolution 2008-01-22 2008-02-05 Joint Center for Structural Genomics (JCSG) Crystal structure of a putative oxidoreductase (ZP_00056571.1) from Magnetospirillum magnetotacticum MS-1 at 1.85 A resolution To be published 0 0 0 0 3C1L Crystal structure of an antioxidant defense protein (mlr4105) from mesorhizobium loti maff303099 at 2.00 A resolution 2008-01-23 2008-02-05 Joint Center for Structural Genomics (JCSG) Crystal structure of putative antioxidant defense protein (NP_105057.1) from Mesorhizobium loti at 2.00 A resolution To be published 0 0 0 0 3C3P Crystal structure of a methyltransferase (NP_951602.1) from Geobacter sulfurreducens at 1.90 A resolution 2008-01-28 2008-02-05 Joint Center for Structural Genomics (JCSG) Crystal structure of a methyltransferase (NP_951602.1) from Geobacter sulfurreducens at 1.90 A resolution To be published 0 0 0 0 3C37 X-ray structure of the putative Zn-dependent peptidase Q74D82 at the resolution 1.7 A. Northeast Structural Genomics Consortium target GsR143A 2008-01-27 2008-02-12 Kuzin, A.P.,Chen, Y.,Seetharaman, J.,Vorobiev, S.M.,Forouhar, F.,Wang, D.,Mao, L.,Maglaqui, M.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. X-ray structure of the putative Zn-dependent peptidase Q74D82 at the resolution 1.7 A. To be Published 0 0 0 0 3BAP 18445629 Crystal Structure of the 25 kDa Subunit of Human Cleavage Factor Im 2007-11-08 2008-02-19 Coseno, M.,Martin, G.,Berger, C.,Gilmartin, G.,Keller, W.,Doublie, S. Crystal structure of the 25 kDa subunit of human cleavage factor Im. Nucleic Acids Res. 2008 36 3474 3483 3BQO 18202258 Crystal Structure of TRF1 TRFH domain and TIN2 peptide complex 2007-12-20 2008-02-19 Chen, Y.,Yang, Y.,van Overbeek, M.,Donigian, J.R.,Baciu, P.,de Lange, T.,Lei, M. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 2008 319 1092 1096 3C9Q Crystal structure of the uncharacterized human protein C8orf32 with bound peptide 2008-02-18 2008-02-26 Bitto, E.,Bingman, C.A.,McCoy, J.G.,Wesenberg, G.E.,Phillips Jr., G.N. Crystal structure of the uncharacterized human protein C8orf32 with bound peptide. To be Published 0 0 0 0 2OYB 18762191 The crystal structure of OspA mutant 2007-02-21 2008-03-04 Biancalana, M.,Makabe, K.,Koide, A.,Koide, S. Aromatic cross-strand ladders control the structure and stability of beta-rich peptide self-assembly mimics J.Mol.Biol. 2008 383 205 213 3CAZ Crystal structure of a BAR protein from Galdieria sulphuraria 2008-02-20 2008-03-04 McCoy, J.G.,Bitto, E.,Bingman, C.A.,Wesenberg, G.E.,Phillips Jr., G.N. Crystal structure of a BAR protein from Galdieria sulphuraria. To be Published 0 0 0 0 2EPK 18237743 N-acetyl-B-D-glucosaminidase (GCNA) from Streptococcus gordonii 2007-03-30 2008-03-11 Langley, D.B.,Harty, D.W.S.,Jacques, N.A.,Hunter, N.,Guss, J.M.,Collyer, C.A. Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the Endocarditis Pathogen Streptococcus gordonii and its Complex with the Mechanism-based Inhibitor NAG-thiazoline J.Mol.Biol. 2008 377 104 116 2EPL 18237743 N-acetyl-B-D-glucosaminidase (GCNA) from Streptococcus gordonii 2007-03-30 2008-03-11 Langley, D.B.,Harty, D.W.S.,Jacques, N.A.,Hunter, N.,Guss, J.M.,Collyer, C.A. Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the Endocarditis Pathogen Streptococcus gordonii and its Complex with the Mechanism-based Inhibitor NAG-thiazoline J.Mol.Biol. 2008 377 104 116 3BOF 18296644 Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima complexed with Zn2+ and Homocysteine 2007-12-17 2008-03-11 Koutmos, M.,Pejchal, R.,Bomer, T.M.,Matthews, R.G.,Smith, J.L.,Ludwig, M.L. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc.Natl.Acad.Sci.Usa 2008 105 3286 3291 3BOL 18296644 Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima complexed with Zn2+ 2007-12-17 2008-03-11 Koutmos, M.,Pejchal, R.,Bomer, T.M.,Matthews, R.G.,Smith, J.L.,Ludwig, M.L. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc.Natl.Acad.Sci.Usa 2008 105 3286 3291 3BQ5 18296644 Crystal Structure of T. maritima Cobalamin-Independent Methionine Synthase complexed with Zn2+ and Homocysteine (Monoclinic) 2007-12-19 2008-03-11 Koutmos, M.,Pejchal, R.,Bomer, T.M.,Matthews, R.G.,Smith, J.L.,Ludwig, M.L. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc.Natl.Acad.Sci.Usa 2008 105 3286 3291 3BQ6 18296644 Crystal Structure of T. maritima Cobalamin-Independent Methionine Synthase complexed with Zn2+ (Monoclinic) 2007-12-19 2008-03-11 Koutmos, M.,Pejchal, R.,Bomer, T.M.,Matthews, R.G.,Smith, J.L.,Ludwig, M.L. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc.Natl.Acad.Sci.Usa 2008 105 3286 3291 3C4Z 18339619 Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A 2008-01-30 2008-03-11 Singh, P.,Wang, B.,Maeda, T.,Palczewski, K.,Tesmer, J.J. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem. 2008 283 14053 14062 3C50 18339619 Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A 2008-01-30 2008-03-11 Singh, P.,Wang, B.,Maeda, T.,Palczewski, K.,Tesmer, J.J. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem. 2008 283 14053 14062 3C51 18339619 Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A 2008-01-30 2008-03-11 Singh, P.,Wang, B.,Maeda, T.,Palczewski, K.,Tesmer, J.J. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J.Biol.Chem. 2008 283 14053 14062 3CE9 Crystal structure of glycerol dehydrogenase (NP_348253.1) from Clostridium acetobutylicum at 2.37 A resolution 2008-02-28 2008-03-11 Joint Center for Structural Genomics (JCSG) Crystal structure of glycerol dehydrogenase (NP_348253.1) from Clostridium acetobutylicum at 2.37 A resolution To be published 0 0 0 0 3CC1 CRYSTAL STRUCTURE OF A PUTATIVE ALPHA-N-ACETYLGALACTOSAMINIDASE (BH1870) FROM BACILLUS HALODURANS C-125 AT 2.00 A RESOLUTION 2008-02-23 2008-03-18 Joint Center for Structural Genomics (JCSG) Crystal structure of putative alpha-N-acetylgalactosaminidase (NP_242736.1) from Bacillus halodurans at 2.00 A resolution To be published 0 0 0 0 3BW1 18329667 Crystal structure of homomeric yeast Lsm3 exhibiting novel octameric ring organisation 2008-01-07 2008-03-25 Naidoo, N.,Harrop, S.J.,Sobti, M.,Haynes, P.A.,Szymczyna, B.R.,Williamson, J.R.,Curmi, P.M.G.,Mabbutt, B.C. Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment J.Mol.Biol. 2008 377 1357 1371 3CLM Crystal structure of transaldolase (YP_208650.1) from Neisseria gonorrhoeae FA 1090 at 1.14 A resolution 2008-03-19 2008-04-01 Joint Center for Structural Genomics (JCSG) Crystal structure of transaldolase (YP_208650.1) from Neisseria gonorrhoeae FA 1090 at 1.14 A resolution To be published 0 0 0 0 3C5X 18369147 Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH 2008-02-01 2008-04-08 Li, L.,Lok, S.M.,Yu, I.M.,Zhang, Y.,Kuhn, R.J.,Chen, J.,Rossmann, M.G. The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 2008 319 1830 1834 3C6E 18369147 Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at neutral pH 2008-02-04 2008-04-08 Li, L.,Lok, S.M.,Yu, I.M.,Zhang, Y.,Kuhn, R.J.,Chen, J.,Rossmann, M.G. The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 2008 319 1830 1834 2QBW 18445649 The crystal structure of PDZ-Fibronectin fusion protein 2007-06-18 2008-04-22 Huang, J.,Koide, A.,Makabe, K.,Koide, S. Design of protein function leaps by directed domain interface evolution. Proc.Natl.Acad.Sci.Usa 2008 105 6578 6583 2ZIH 18410729 Crystal Structure of Yeast Vps74 2008-02-18 2008-04-22 Schmitz, K.R.,Liu, J.,Li, S.,Setty, T.G.,Wood, C.S.,Burd, C.G.,Ferguson, K.M. Golgi localization of glycosyltransferases requires a Vps74p oligomer. Dev.Cell 2008 14 523 534 2ZIH 18410729 Crystal Structure of Yeast Vps74 2008-02-18 2008-04-22 Schmitz, K.R.,Liu, J.,Li, S.,Setty, T.G.,Wood, C.S.,Burd, C.G.,Ferguson, K.M. Golgi localization of glycosyltransferases requires a Vps74p oligomer. Dev.Cell 2008 14 523 534 3C9A 18500331 High Resolution Crystal Structure of Argos bound to the EGF domain of Spitz 2008-02-15 2008-05-20 Klein, D.E.,Stayrook, S.E.,Shi, F.,Narayan, K.,Lemmon, M.A. Structural basis for EGFR ligand sequestration by Argos. Nature 2008 453 1271 1275 3CA7 18500331 High Resolution Crystal Structure of the EGF domain of Spitz 2008-02-19 2008-05-20 Klein, D.E.,Stayrook, S.E.,Shi, F.,Narayan, K.,Lemmon, M.A. Structural basis for EGFR ligand sequestration by Argos. Nature 2008 453 1271 1275 3CZ6 18538788 Crystal Structure of the Rap1 C-terminus 2008-04-28 2008-05-20 Feeser, E.A.,Wolberger, C. Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants. J.Mol.Biol. 2008 380 520 531 2PI3 25645104 The crystal structure of OspA mutant 2007-04-12 2008-05-27 Biancalana, M.,Makabe, K.,Yan, S.,Koide, S. Aromatic cluster mutations produce focal modulations of beta-sheet structure. Protein Sci. 2015 24 841 849 3CSF 18484710 Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2 2008-04-09 2008-05-27 Xie, P.,Williams, D.S.,Atilla-Gokcumen, G.E.,Milk, L.,Xiao, M.,Smalley, K.S.,Herlyn, M.,Meggers, E.,Marmorstein, R. Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. Acs Chem.Biol. 2008 3 305 316 3BQ4 18336857 Crystal Structure of Ad35 fiber knob 2007-12-19 2008-06-03 Pache, L.,Venkataraman, S.,Nemerow, G.R.,Reddy, V.S. Conservation of fiber structure and CD46 usage by subgroup B2 adenoviruses Virology 2008 375 573 579 3BWY 18486144 Crystal Structure of Human 108M Catechol O-methyltransferase bound with S-adenosylmethionine and inhibitor dinitrocatechol 2008-01-10 2008-06-03 Rutherford, K.,Le Trong, I.,Stenkamp, R.E.,Parson, W.W. Crystal structures of human 108V and 108M catechol O-methyltransferase. J.Mol.Biol. 2008 380 120 130 3D5T Crystal structure of malate dehydrogenase from Burkholderia pseudomallei 2008-05-16 2008-06-03 Seattle Structural Genomics Center for Infectious Disease (SSGCID) Crystal Structure of Malate Dehydrogenase from Burkholderia pseudomallei. To be Published 0 0 0 0 3D64 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei 2008-05-18 2008-06-03 Seattle Structural Genomics Center for Infectious Disease (SSGCID) Crystal structure of S-adenosyl-L-homocysteine hydrolase from Burkholderia pseudomallei. To be Published 0 0 0 0 3D6B 21904051 2.2 A crystal structure of glutaryl-CoA dehydrogenase from Burkholderia pseudomallei 2008-05-19 2008-06-03 Begley, D.W.,Davies, D.R.,Hartley, R.C.,Hewitt, S.N.,Rychel, A.L.,Myler, P.J.,Van Voorhis, W.C.,Staker, B.L.,Stewart, L.J. Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening. Acta Crystallogr.,Sect.F 2011 67 1060 1069 3DAH 23382856 2.3 A crystal structure of ribose-phosphate pyrophosphokinase from Burkholderia pseudomallei 2008-05-29 2008-06-10 Baugh, L.,Gallagher, L.A.,Patrapuvich, R.,Clifton, M.C.,Gardberg, A.S.,Edwards, T.E.,Armour, B.,Begley, D.W.,Dieterich, S.H.,Dranow, D.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Staker, B.L.,Phan, I.,Gillespie, A.,Choi, R.,Nakazawa-Hewitt, S.,Nguyen, M.T.,Napuli, A.,Barrett, L.,Buchko, G.W.,Stacy, R.,Myler, P.J.,Stewart, L.J.,Manoil, C.,Van Voorhis, W.C. Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One 2013 8 0 0 3CNC 18524830 Crystal Structure of Ad16 fiber knob 2008-03-25 2008-06-17 Pache, L.,Venkataraman, S.,Reddy, V.S.,Nemerow, G.R. Structural variations in species B adenovirus fibers impact CD46 association J.Virol. 2008 82 7923 7931 3D4S 18547522 Cholesterol bound form of human beta2 adrenergic receptor. 2008-05-14 2008-06-17 Hanson, M.A.,Cherezov, V.,Griffith, M.T.,Roth, C.B.,Jaakola, V.P.,Chien, E.Y.,Velasquez, J.,Kuhn, P.,Stevens, R.C. A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure 2008 16 897 905 3DET 18678918 Structure of the E148A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter 2008-06-10 2008-06-17 Jayaram, H.,Accardi, A.,Wu, F.,Williams, C.,Miller, C. Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger Proc.Natl.Acad.Sci.USA 2008 105 11194 11199 3D0Q 18721755 Crystal structure of calG3 from Micromonospora echinospora determined in space group I222 2008-05-02 2008-06-24 Zhang, C.,Bitto, E.,Goff, R.D.,Singh, S.,Bingman, C.A.,Griffith, B.R.,Albermann, C.,Phillips, G.N.,Thorson, J.S. Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. Chem.Biol. 2008 15 842 853 3D0R 18721755 Crystal structure of calG3 from Micromonospora echinospora determined in space group P2(1) 2008-05-02 2008-06-24 Zhang, C.,Bitto, E.,Goff, R.D.,Singh, S.,Bingman, C.A.,Griffith, B.R.,Albermann, C.,Phillips, G.N.,Thorson, J.S. Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. Chem.Biol. 2008 15 842 853 3DEU 30837332 Crystal structure of transcription regulatory protein slyA from Salmonella typhimurium in complex with salicylate ligands 2008-06-10 2008-06-24 Will, W.R.,Brzovic, P.,Le Trong, I.,Stenkamp, R.E.,Lawrenz, M.B.,Karlinsey, J.E.,Navarre, W.W.,Main-Hester, K.,Miller, V.L.,Libby, S.J.,Fang, F.C. The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in Enterobacteriaceae . Mbio 2019 10 0 0 3CSQ 18606992 Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail 2008-04-10 2008-07-01 Xiang, Y.,Morais, M.C.,Cohen, D.N.,Bowman, V.D.,Anderson, D.L.,Rossmann, M.G. Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail. Proc.Natl.Acad.Sci.Usa 2008 105 9552 9557 3DCY Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens. 2008-06-04 2008-07-15 McCoy, J.G.,Bingman, C.A.,Wesenberg, G.E.,Phillips Jr., G.N. Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens. To be Published 0 0 0 0 3DMO 1.6 A crystal structure of cytidine deaminase from Burkholderia pseudomallei 2008-07-01 2008-07-15 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.6 A crystal structure of cytidine deaminase from Burkholderia pseudomallei To be Published 0 0 0 0 3DMP 2.6 A crystal structure of uracil phosphoribosyltransferase from Burkholderia pseudomallei 2008-07-01 2008-07-15 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 2.6 A crystal structure of uracil phosphoribosyltransferase from Burkholderia pseudomallei To be Published 0 0 0 0 3DMS 21870819 1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei 2008-07-01 2008-07-15 Yates, S.P.,Edwards, T.E.,Bryan, C.M.,Stein, A.J.,Van Voorhis, W.C.,Myler, P.J.,Stewart, L.J.,Zheng, J.,Jia, Z. Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry 2011 50 8103 8106 3CSB 18602117 Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex 2008-04-09 2008-07-22 Gilbreth, R.N.,Esaki, K.,Koide, A.,Sidhu, S.S.,Koide, S. A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces J.Mol.Biol. 2008 381 407 418 3CKN 18667419 Crystal Structure of a Mycobacterial Protein 2008-03-16 2008-07-29 Fulton, Z.,McAlister, A.,Wilce, M.C.,Brammananth, R.,Zaker-Tabrizi, L.,Perugini, M.A.,Bottomley, S.P.,Coppel, R.L.,Crellin, P.K.,Rossjohn, J.,Beddoe, T. Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species. J.Biol.Chem. 2008 283 27881 27890 3CKV 18667419 Crystal Structure of a Mycobacterial Protein 2008-03-17 2008-07-29 Fulton, Z.,McAlister, A.,Wilce, M.C.,Brammananth, R.,Zaker-Tabrizi, L.,Perugini, M.A.,Bottomley, S.P.,Coppel, R.L.,Crellin, P.K.,Rossjohn, J.,Beddoe, T. Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species. J.Biol.Chem. 2008 283 27881 27890 3DHA 18627129 An Ultral High Resolution Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homoserine Bound at An Alternative Site 2008-06-17 2008-07-29 Liu, D.,Momb, J.,Thomas, P.W.,Moulin, A.,Petsko, G.A.,Fast, W.,Ringe, D. Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry 2008 47 7706 7714 3DHB 18627129 1.4 Angstrom Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homoserine Bound at The Catalytic Metal Center 2008-06-17 2008-07-29 Liu, D.,Momb, J.,Thomas, P.W.,Moulin, A.,Petsko, G.A.,Fast, W.,Ringe, D. Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry 2008 47 7706 7714 3DHC 18627129 1.3 Angstrom Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homocysteine Bound to The catalytic Metal Center 2008-06-17 2008-07-29 Liu, D.,Momb, J.,Thomas, P.W.,Moulin, A.,Petsko, G.A.,Fast, W.,Ringe, D. Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures. Biochemistry 2008 47 7706 7714 3DH4 18599740 Crystal Structure of Sodium/Sugar symporter with bound Galactose from vibrio parahaemolyticus 2008-06-16 2008-08-05 Faham, S.,Watanabe, A.,Besserer, G.M.,Cascio, D.,Specht, A.,Hirayama, B.A.,Wright, E.M.,Abramson, J. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science 2008 321 810 814 3DCK 18657969 X-ray structure of D25N chemical analogue of HIV-1 protease complexed with ketomethylene isostere inhibitor 2008-06-03 2008-08-19 Torbeev, V.Y.,Mandal, K.,Terechko, V.A.,Kent, S.B.H. Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site Bioorg.Med.Chem.Lett. 2008 18 4554 4557 3DLJ Crystal structure of human carnosine dipeptidase 1 2008-06-27 2008-08-19 Dobrovetsky, E.,Dong, A.,Seitova, A.,He, H.,Tempel, W.,Kozieradzki, I.,Arrowsmith, C.H.,Weigelt, J.,Bountra, C.,Edwards, A.M.,Bochkarev, A.,Cossar, D. Crystal structure of human carnosine dipeptidase 1. To be Published 0 0 0 0 3E3P Glycogen synthase kinase from Leishmania major 2008-08-07 2008-08-19 Arakaki, T.L.,Merritt, E.A. Glycogen synthase kinase from Leishmania major To be Published 0 0 0 0 3E60 Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Bartonella henselae 2008-08-14 2008-08-26 Seattle Structural Genomics Center for Infectious Disease (SSGCID) Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Bartonella henselae To be Published 0 0 0 0 3E7D Crystal Structure of Precorrin-8X Methyl Mutase CbiC/CobH from Brucella melitensis 2008-08-18 2008-08-26 Seattle Structural Genomics Center for Infectious Disease (SSGCID) Crystal Structure of Precorrin-8X Methyl Mutase CbiC/CobH from Brucella melitensis To be Published 0 0 0 0 2VYA 18753625 Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750 2008-07-22 2008-09-09 Mileni, M.,Johnson, D.S.,Wang, Z.,Everdeen, D.S.,Liimatta, M.,Pabst, B.,Bhattacharya, K.,Nugent, R.A.,Kamtekar, S.,Cravatt, B.F.,Ahn, K.,Stevens, R.C. Structure-Guided Inhibitor Design for Human Faah by Interspecies Active Site Conversion. Proc.Natl.Acad.Sci.USA 2008 105 12820 0 3DZO 19197235 Crystal structure of a rhoptry kinase from toxoplasma gondii 2008-07-30 2008-09-16 Qiu, W.,Wernimont, A.,Tang, K.,Taylor, S.,Lunin, V.,Schapira, M.,Fentress, S.,Hui, R.,Sibley, L.D. Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii. Embo J. 2009 28 969 979 3EB0 Crystal Structure of cgd4_240 from cryptosporidium Parvum in complex with indirubin E804 2008-08-26 2008-09-16 Wernimont, A.K.,Fedorov, O.,Lam, A.,Ali, A.,Zhao, Y.,Lew, J.,Wasney, G.,Vedadi, M.,Kozieradzki, I.,Schapira, M.,Bochkarev, A.,Wilstrom, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Hui, R.,Lin, Y.H. Crystal Structure of cgd4_240 from cryptosporidium Parvum in complex with indirubin E804 TO BE PUBLISHED 0 0 0 0 3BOG 18598029 Snow Flea Antifreeze Protein Quasi-racemate 2007-12-17 2008-09-23 Pentelute, B.L.,Gates, Z.P.,Tereshko, V.,Dashnau, J.L.,Vanderkooi, J.M.,Kossiakoff, A.A.,Kent, S.B. X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers J.Am.Chem.Soc. 2008 130 9695 9701 3EO2 Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein 2008-09-26 2008-10-07 Nedyalkova, L.,Tong, Y.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H. Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein To be Published 0 0 0 0 3ECI Microtubule-associated protein 1 light chain 3 alpha isoform A (MAP1ALC3) 2008-08-30 2008-10-14 Walker, J.R.,Davis, T.L.,Mujib, S.,Butler-Cole, C.,Tempel, W.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. Human Autophagy-Related Protein LC3 A To be Published 0 0 0 0 3CX7 18940608 Crystal Structure of PDZRhoGEF rgRGS Domain in a Complex with Galpha-13 Bound to GDP-AlF4 2008-04-23 2008-10-28 Chen, Z.,Singer, W.D.,Danesh, S.M.,Sternweis, P.C.,Sprang, S.R. Recognition of the Activated States of Galpha13 by the rgRGS Domain of PDZRhoGEF. Structure 2008 16 1532 1543 3ENK 1.9A crystal structure of udp-glucose 4-epimerase from burkholderia pseudomallei 2008-09-25 2008-10-28 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 1.9A crystal structure of udp-glucose 4-epimerase from burkholderia pseudomallei To be Published 0 0 0 0 3EZ4 Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase from Burkholderia pseudomallei 2008-10-22 2008-11-04 Edwards, T.E. Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase from Burkholderia pseudomallei To be Published 0 0 0 0 3F0D 21359640 High resolution crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphatase synthase from Burkholderia pseudomallei 2008-10-24 2008-11-04 Begley, D.W.,Hartley, R.C.,Davies, D.R.,Edwards, T.E.,Leonard, J.T.,Abendroth, J.,Burris, C.A.,Bhandari, J.,Myler, P.J.,Staker, B.L.,Stewart, L.J. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics 2011 12 63 76 3F6B 19140682 Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor PAA 2008-11-05 2008-12-09 Chakraborty, S.,Nemeria, N.S.,Balakrishnan, A.,Brandt, G.S.,Kneen, M.M.,Yep, A.,McLeish, M.J.,Kenyon, G.L.,Petsko, G.A.,Ringe, D.,Jordan, F. Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase. Biochemistry 2009 48 981 994 3F6E 19140682 Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor 3-PKB 2008-11-05 2008-12-09 Chakraborty, S.,Nemeria, N.S.,Balakrishnan, A.,Brandt, G.S.,Kneen, M.M.,Yep, A.,McLeish, M.J.,Kenyon, G.L.,Petsko, G.A.,Ringe, D.,Jordan, F. Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase. Biochemistry 2009 48 981 994 3E86 19098917 High resolution Crystal Structure of the open NaK channel pore 2008-08-19 2008-12-23 Alam, A.,Jiang, Y. High-resolution structure of the open NaK channel Nat.Struct.Mol.Biol. 2009 16 30 34 3EGB 19081057 Structure of Pellino2 FHA domain at 3.3 Angstroms resolution. 2008-09-10 2008-12-23 Lin, C.C.,Huoh, Y.S.,Schmitz, K.R.,Jensen, L.E.,Ferguson, K.M. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Structure 2008 16 1806 1816 3DHG 19033467 Crystal Structure of Toluene 4-Monoxygenase Hydroxylase 2008-06-17 2008-12-30 Bailey, L.J.,McCoy, J.G.,Phillips Jr., G.N.,Fox, B.G. Structural consequences of effector protein complex formation in a diiron hydroxylase. Proc.Natl.Acad.Sci.USA 2008 105 19194 19198 3DHH 19033467 Crystal Structure of Resting State Toluene 4-Monoxygenase Hydroxylase Complexed with Effector Protein 2008-06-17 2008-12-30 Bailey, L.J.,McCoy, J.G.,Phillips Jr., G.N.,Fox, B.G. Structural consequences of effector protein complex formation in a diiron hydroxylase. Proc.Natl.Acad.Sci.USA 2008 105 19194 19198 3FLA 19103602 RifR - Type II thioesterase from Rifamycin NRPS/PKS biosynthetic pathway - Form 1 2008-12-18 2009-01-06 Claxton, H.B.,Akey, D.L.,Silver, M.K.,Admiraal, S.J.,Smith, J.L. Structure and Functional Analysis of RifR, the Type II Thioesterase from the Rifamycin Biosynthetic Pathway. J.Biol.Chem. 2009 284 5021 5029 3FLB 19103602 RifR - Type II thioesterase from Rifamycin NRPS/PKS biosynthetic pathway - Form 2 2008-12-18 2009-01-06 Claxton, H.B.,Akey, D.L.,Silver, M.K.,Admiraal, S.J.,Smith, J.L. Structure and Functional Analysis of RifR, the Type II Thioesterase from the Rifamycin Biosynthetic Pathway. J.Biol.Chem. 2009 284 5021 5029 3CKF 18842042 The crystal structure of OspA deletion mutant 2008-03-14 2009-01-27 Makabe, K.,Koide, S. The promiscuity of beta-strand pairing allows for rational design of beta-sheet face inversion J.Am.Chem.Soc. 2008 130 14370 14371 3F5H 19146481 Crystal structure of fused docking domains from PikAIII and PikAIV of the pikromycin polyketide synthase 2008-11-03 2009-01-27 Buchholz, T.J.,Geders, T.W.,Bartley, F.E.,Reynolds, K.A.,Smith, J.L.,Sherman, D.H. Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. Acs Chem.Biol. 2009 4 41 52 3FSJ 19320438 Crystal structure of benzoylformate decarboxylase in complex with the inhibitor MBP 2009-01-09 2009-01-27 Brandt, G.S.,Kneen, M.M.,Chakraborty, S.,Baykal, A.T.,Nemeria, N.,Yep, A.,Ruby, D.I.,Petsko, G.A.,Kenyon, G.L.,McLeish, M.J.,Jordan, F.,Ringe, D. Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor. Biochemistry 2009 48 3247 3257 3EC5 19038267 The crystal structure of Thioflavin-T (ThT) binding OspA mutant 2008-08-28 2009-02-03 Biancalana, M.,Makabe, K.,Koide, A.,Koide, S. Molecular mechanism of thioflavin-T binding to the surface of beta-rich peptide self-assemblies J.Mol.Biol. 2009 385 1052 1063 3FVB Crystal structure of ferritin (bacterioferritin) from Brucella melitensis 2009-01-15 2009-02-03 Seattle Structural Genomics Center for Infectious Disease (SSGCID) Crystal structure of ferritin from Brucella melitensis To be Published 0 0 0 0 3E8Y 19133782 Xray structure of scorpion toxin BmBKTx1 2008-08-20 2009-02-10 Mandal, K.,Pentelute, B.L.,Tereshko, V.,Kossiakoff, A.A.,Kent, S.B. X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. J.Am.Chem.Soc. 2009 131 1362 1363 3EDT Crystal structure of the mutated S328N hKLC2 TPR domain 2008-09-03 2009-02-10 Zhu, H.,Shen, Y.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H. Crystal structure of mutated S328N TPR domain of human kinesin light chain 2 To be published 0 0 0 0 3DRX 19361449 X-ray crystal structure of human KCTD5 protein crystallized in high-salt buffer 2008-07-11 2009-02-17 Dementieva, I.S.,Tereshko, V.,McCrossan, Z.A.,Solomaha, E.,Araki, D.,Xu, C.,Grigorieff, N.,Goldstein, S.A. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. J.Mol.Biol. 2009 387 175 191 3DRY 19361449 X-ray crystal structure of human KCTD5 protein crystallized in low-salt buffer 2008-07-11 2009-02-17 Dementieva, I.S.,Tereshko, V.,McCrossan, Z.A.,Solomaha, E.,Araki, D.,Xu, C.,Grigorieff, N.,Goldstein, S.A. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. J.Mol.Biol. 2009 387 175 191 3DRZ 19361449 X-ray crystal structure of the N-terminal BTB domain of human KCTD5 protein 2008-07-11 2009-02-17 Dementieva, I.S.,Tereshko, V.,McCrossan, Z.A.,Solomaha, E.,Araki, D.,Xu, C.,Grigorieff, N.,Goldstein, S.A. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. J.Mol.Biol. 2009 387 175 191 3E8K 19204733 Crystal structure of HK97 Prohead II 2008-08-20 2009-02-17 Gertsman, I.,Gan, L.,Guttman, M.,Lee, K.,Speir, J.A.,Duda, R.L.,Hendrix, R.W.,Komives, E.A.,Johnson, J.E. An unexpected twist in viral capsid maturation. Nature 2009 458 646 650 3G5W 19224923 Crystal structure of Blue Copper Oxidase from Nitrosomonas europaea 2009-02-05 2009-02-17 Lawton, T.J.,Sayavedra-Soto, L.A.,Arp, D.J.,Rosenzweig, A.C. Crystal structure of a two-domain multicopper oxidase: implications for the evolution of multicopper blue proteins. J.Biol.Chem. 2009 284 10174 10180 3FH6 19250913 Crystal structure of the resting state maltose transporter from E. coli 2008-12-08 2009-03-03 Khare, D.,Oldham, M.L.,Orelle, C.,Davidson, A.L.,Chen, J. Alternating access in maltose transporter mediated by rigid-body rotations. Mol.Cell 2009 33 528 536 3G9Y 19304800 Crystal structure of the second zinc finger from ZRANB2/ZNF265 bound to 6 nt ssRNA sequence AGGUAA 2009-02-15 2009-03-03 Loughlin, F.E.,Mansfield, R.E.,Vaz, P.M.,McGrath, A.P.,Setiyaputra, S.,Gamsjaeger, R.,Chen, E.S.,Morris, B.J.,Guss, J.M.,Mackay, J.P. The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences Proc.Natl.Acad.Sci.USA 2009 106 5581 5586 3GAN Crystal structure of gene product from Arabidopsis thaliana At3g22680 with bound suramin 2009-02-17 2009-03-03 Burgie, E.S.,Bingman, C.A.,Wesenberg, G.E.,Phillips Jr., G.N. Crystal structure of gene product from Arabidopsis thaliana At3g22680 with bound suramin To be Published 0 0 0 0 3FO8 19229296 Crystal structure of the bacteriophage T4 tail sheath protein, protease resistant fragment gp18PR 2008-12-29 2009-03-10 Aksyuk, A.A.,Leiman, P.G.,Kurochkina, L.P.,Shneider, M.M.,Kostyuchenko, V.A.,Mesyanzhinov, V.V.,Rossmann, M.G. The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria. Embo J. 2009 28 821 829 3FOA 19229296 Crystal structure of the bacteriophage T4 tail sheath protein, deletion mutant gp18M 2008-12-29 2009-03-10 Aksyuk, A.A.,Leiman, P.G.,Kurochkina, L.P.,Shneider, M.M.,Kostyuchenko, V.A.,Mesyanzhinov, V.V.,Rossmann, M.G. The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria. Embo J. 2009 28 821 829 3G60 19325113 Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding 2009-02-05 2009-03-24 Aller, S.G.,Yu, J.,Ward, A.,Weng, Y.,Chittaboina, S.,Zhuo, R.,Harrell, P.M.,Trinh, Y.T.,Zhang, Q.,Urbatsch, I.L.,Chang, G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 2009 323 1718 1722 3GNN Crystal structure of nicotinate-nucleotide pyrophosphorylase from Burkholderi pseudomallei 2009-03-17 2009-03-31 Seattle Structural Genomics Center for Infectious Disease (SSGCID) Crystal structure of nicotinate-nucleotide pyrophosphorylase from Burkholderi pseudomallei To be Published 0 0 0 0 3GP3 21904048 Crystal structure of phosphoglyceromutase from Burkholderia pseudomallei with 2-phosphoserine 2009-03-20 2009-03-31 Davies, D.R.,Staker, B.L.,Abendroth, J.A.,Edwards, T.E.,Hartley, R.,Leonard, J.,Kim, H.,Rychel, A.L.,Hewitt, S.N.,Myler, P.J.,Stewart, L.J. An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase. Acta Crystallogr.,Sect.F 2011 67 1044 1050 3F3G 19111661 Crystal structure of the nucleoporin pair Nup85-Seh1, space group P212121 2008-10-30 2009-04-07 Debler, E.W.,Ma, Y.,Seo, H.S.,Hsia, K.C.,Noriega, T.R.,Blobel, G.,Hoelz, A. A fence-like coat for the nuclear pore membrane. Mol.Cell 2008 32 815 826 3GVC 25613812 Crystal structure of probable short-chain dehydrogenase-reductase from Mycobacterium tuberculosis 2009-03-30 2009-04-07 Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb) 2015 95 142 148 3EFD 19346472 The crystal structure of the cytoplasmic domain of KcsA 2008-09-08 2009-04-14 Uysal, S.,Vasquez, V.,Tereshko, V.,Esaki, K.,Fellouse, F.A.,Sidhu, S.S.,Koide, S.,Perozo, E.,Kossiakoff, A. Crystal structure of full-length KcsA in its closed conformation. Proc.Natl.Acad.Sci.USA 2009 106 6644 6649 3EFF 19346472 The Crystal Structure of Full-Length KcsA in its Closed Conformation 2008-09-08 2009-04-14 Uysal, S.,Vasquez, V.,Tereshko, V.,Esaki, K.,Fellouse, F.A.,Sidhu, S.S.,Koide, S.,Perozo, E.,Kossiakoff, A. Crystal structure of full-length KcsA in its closed conformation. Proc.Natl.Acad.Sci.USA 2009 106 6644 6649 3GVG 25613812 Crystal structure of Triosephosphate isomerase from Mycobacterium tuberculosis 2009-03-31 2009-04-14 Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb) 2015 95 142 148 3GVI Crystal structure of Lactate/malate dehydrogenase from Brucella melitensis in complex with ADP 2009-03-31 2009-04-14 Abendroth, J.,Staker, B. Crystal structure of Lactate/malate dehydrogenase from Brucella melitensis in complex with ADP To be Published 0 0 0 0 3GVF 23382856 1.7 Angstrom crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei bound with phosphate 2009-03-30 2009-04-28 Baugh, L.,Gallagher, L.A.,Patrapuvich, R.,Clifton, M.C.,Gardberg, A.S.,Edwards, T.E.,Armour, B.,Begley, D.W.,Dieterich, S.H.,Dranow, D.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Staker, B.L.,Phan, I.,Gillespie, A.,Choi, R.,Nakazawa-Hewitt, S.,Nguyen, M.T.,Napuli, A.,Barrett, L.,Buchko, G.W.,Stacy, R.,Myler, P.J.,Stewart, L.J.,Manoil, C.,Van Voorhis, W.C. Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One 2013 8 0 0 3GWA 23382856 1.6 Angstrom crystal structure of 3-oxoacyl-(acyl-carrier-protein) synthase III 2009-03-31 2009-04-28 Baugh, L.,Gallagher, L.A.,Patrapuvich, R.,Clifton, M.C.,Gardberg, A.S.,Edwards, T.E.,Armour, B.,Begley, D.W.,Dieterich, S.H.,Dranow, D.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Staker, B.L.,Phan, I.,Gillespie, A.,Choi, R.,Nakazawa-Hewitt, S.,Nguyen, M.T.,Napuli, A.,Barrett, L.,Buchko, G.W.,Stacy, R.,Myler, P.J.,Stewart, L.J.,Manoil, C.,Van Voorhis, W.C. Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One 2013 8 0 0 3GWC 25613812 Crystal structure of Mycobacterium tuberculosis thymidylate synthase X bound to FdUMP and FAD 2009-03-31 2009-04-28 Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb) 2015 95 142 148 3GXD 19374450 Crystal structure of Apo acid-beta-glucosidase pH 4.5 2009-04-02 2009-05-05 Lieberman, R.L.,D'aquino, J.A.,Ringe, D.,Petsko, G.A. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. 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Science 2011 332 322 327 3QIT 21357626 Thioesterase Domain From Curacin Biosynthetic Pathway 2011-01-27 2011-03-09 Gehret, J.J.,Gu, L.,Gerwick, W.H.,Wipf, P.,Sherman, D.H.,Smith, J.L. Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE. J.Biol.Chem. 2011 286 14445 14454 3NVO The Soluble Domain Structure of the ZntB Zn2+ Efflux System 2010-07-08 2011-03-23 Wan, Q.,Gorzelle, B.,Fuente, M.,Mohammed, F.,Dealwis, C.,Maguire, M. The Soluble Domain Structure of the ZntB Zn2+ Efflux System To be Published 0 0 0 0 3OLM 21399621 Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase 2010-08-26 2011-03-23 Kim, H.C.,Steffen, A.M.,Oldham, M.L.,Chen, J.,Huibregtse, J.M. Structure and function of a HECT domain ubiquitin-binding site. Embo Rep. 2011 12 334 341 3QYG 21473592 Crystal Structure of Co-type Nitrile Hydratase beta-E56Q from Pseudomonas putida. 2011-03-03 2011-03-23 Brodkin, H.R.,Novak, W.R.,Milne, A.C.,D'Aquino, J.A.,Karabacak, N.M.,Goldberg, I.G.,Agar, J.N.,Payne, M.S.,Petsko, G.A.,Ondrechen, M.J.,Ringe, D. Evidence of the Participation of Remote Residues in the Catalytic Activity of Co-Type Nitrile Hydratase from Pseudomonas putida. Biochemistry 2011 50 4923 4935 3QZ5 21473592 Crystal Structure of Co-type Nitrile Hydratase alpha-E168Q from Pseudomonas putida. 2011-03-04 2011-03-23 Brodkin, H.R.,Novak, W.R.,Milne, A.C.,D'Aquino, J.A.,Karabacak, N.M.,Goldberg, I.G.,Agar, J.N.,Payne, M.S.,Petsko, G.A.,Ondrechen, M.J.,Ringe, D. Evidence of the Participation of Remote Residues in the Catalytic Activity of Co-Type Nitrile Hydratase from Pseudomonas putida. 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Crystal Structure of the His70Phe mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4JU9 Crystal Structure of the His70Leu mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-03-24 2013-04-17 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. Crystal Structure of the His70Leu mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4JUA Crystal Structure of the His70Ser mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-03-24 2013-04-17 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. Crystal Structure of the His70Ser mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4JUC Crystal Structure of the Ser26Met mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-03-24 2013-04-17 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. 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Proc.Natl.Acad.Sci.USA 2013 110 8075 8080 4JUF Crystal Structure of His281Ala mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-03-24 2013-05-01 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. Crystal Structure of His281Ala mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4JUB Crystal Structure of the His70Thr mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-03-24 2013-05-08 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. Crystal Structure of the His70Thr mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4K9K Crystal Structure of the His281Tyr mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-04-20 2013-05-08 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. Crystal Structure of the His281Tyr mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4K9L Crystal Structure of the His281Thr mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-04-20 2013-05-08 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. Crystal Structure of the His281Thr mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4K9M Crystal Structure of the His281Asn mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-04-20 2013-05-08 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. Crystal Structure of the His281Asn mutant of Benzoylformate Decarboxylase from Pseudomonas putida To be Published 0 0 0 0 4K9N Crystal Structure of the Ala460Ile mutant of Benzoylformate Decarboxylase from Pseudomonas putida 2013-04-20 2013-05-08 Brodkin, H.R.,Andrews, F.H.,Milne, A.C.,Petsko, G.A.,Ringe, D.,McLeish, M.J. 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IUCrJ 2017 4 439 454 5VJL 28617868 Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTc 2017-04-19 2017-05-24 de Vries, R.P.,Peng, W.,Grant, O.C.,Thompson, A.J.,Zhu, X.,Bouwman, K.M.,de la Pena, A.T.T.,van Breemen, M.J.,Ambepitiya Wickramasinghe, I.N.,de Haan, C.A.M.,Yu, W.,McBride, R.,Sanders, R.W.,Woods, R.J.,Verheije, M.H.,Wilson, I.A.,Paulson, J.C. Three mutations switch H7N9 influenza to human-type receptor specificity. PLoS Pathog. 2017 13 0 0 5VJM 28617868 Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTa 2017-04-19 2017-05-24 de Vries, R.P.,Peng, W.,Grant, O.C.,Thompson, A.J.,Zhu, X.,Bouwman, K.M.,de la Pena, A.T.T.,van Breemen, M.J.,Ambepitiya Wickramasinghe, I.N.,de Haan, C.A.M.,Yu, W.,McBride, R.,Sanders, R.W.,Woods, R.J.,Verheije, M.H.,Wilson, I.A.,Paulson, J.C. 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Cell Host Microbe 2017 21 742 0 5VTV 28618270 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 3'-SLN 2017-05-18 2017-06-28 Wu, N.C.,Xie, J.,Zheng, T.,Nycholat, C.M.,Grande, G.,Paulson, J.C.,Lerner, R.A.,Wilson, I.A. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe 2017 21 742 0 5VTW 28618270 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 6'-SLN 2017-05-18 2017-06-28 Wu, N.C.,Xie, J.,Zheng, T.,Nycholat, C.M.,Grande, G.,Paulson, J.C.,Lerner, R.A.,Wilson, I.A. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe 2017 21 742 0 5VTY 28618270 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 3'-SLN 2017-05-18 2017-06-28 Wu, N.C.,Xie, J.,Zheng, T.,Nycholat, C.M.,Grande, G.,Paulson, J.C.,Lerner, R.A.,Wilson, I.A. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe 2017 21 742 0 5VTZ 28618270 Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant apo form 2017-05-18 2017-06-28 Wu, N.C.,Xie, J.,Zheng, T.,Nycholat, C.M.,Grande, G.,Paulson, J.C.,Lerner, R.A.,Wilson, I.A. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. 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J.Mol.Biol. 2024 436 168405 168405 6UUQ 32936779 Structure of Calcineurin bound to RCAN1 2019-10-31 2020-09-09 Li, Y.,Sheftic, S.R.,Grigoriu, S.,Schwieters, C.D.,Page, R.,Peti, W. The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin. Sci Adv 2020 6 0 0 6P3D 32873792 The co-crystal structure of BRAF(V600E) with ponatinib 2019-05-23 2020-09-23 Cotto-Rios, X.M.,Agianian, B.,Gitego, N.,Zacharioudakis, E.,Giricz, O.,Wu, Y.,Zou, Y.,Verma, A.,Poulikakos, P.I.,Gavathiotis, E. Inhibitors of BRAF dimers using an allosteric site. Nat Commun 2020 11 4370 4370 6P7G 32873792 The co-crystal structure of BRAF(V600E) with PHI1 2019-06-05 2020-09-23 Cotto-Rios, X.M.,Agianian, B.,Gitego, N.,Zacharioudakis, E.,Giricz, O.,Wu, Y.,Zou, Y.,Verma, A.,Poulikakos, P.I.,Gavathiotis, E. Inhibitors of BRAF dimers using an allosteric site. Nat Commun 2020 11 4370 4370 6Q1Q A hypothetical aminotransferase from Mycobacterium tuberculosis, apo form 2019-08-05 2020-09-23 Duan, L.,Sacchettini, J. A hypothetical aminotransferase from Mycobacterium tuberculosis To Be Published 0 0 0 0 6Q1S A hypothetical aminotransferase from Mycobacterium tuberculosis, alpha-ketoglutarate and PMP bound form 2019-08-05 2020-09-23 Duan, L.,Sacchettini, J. A hypothetical aminotransferase from Mycobacterium tuberculosis To Be Published 0 0 0 0 6UTK Crystal structure of 438-B11 Fab in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 at 3.80 Angstrom 2019-10-29 2020-09-23 Kumar, S.,Ju, B.,Shapiro, B.,Lin, X.,Ren, L.,Zhang, L.,Li, D.,Zhou, Z.,Feng, Y.,Sou, C.,Mann, C.J.,Hao, Y.,Sarkar, A.,Jou, J.,Nunnally, C.,Hong, K.,Wang, S.,Ge, X.,Su, B.,Landais, E.,Sok, D.,Zwick, M.B.,He, L.,Zhu, J.,Wilson, I.A.,Shao, Z. A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite Sci Adv 2020 6 0 0 6UUL 32938661 Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5 2019-10-30 2020-09-23 Kumar, S.,Ju, B.,Shapero, B.,Lin, X.,Ren, L.,Zhang, L.,Li, D.,Zhou, Z.,Feng, Y.,Sou, C.,Mann, C.J.,Hao, Y.,Sarkar, A.,Hou, J.,Nunnally, C.,Hong, K.,Wang, S.,Ge, X.,Su, B.,Landais, E.,Sok, D.,Zwick, M.B.,He, L.,Zhu, J.,Wilson, I.A.,Shao, Y. A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Sci Adv 2020 6 0 0 6UUM 32938661 Crystal structure of antibody 438-B11 DSS mutant (Cys98A-Cys100aA) 2019-10-30 2020-09-23 Kumar, S.,Ju, B.,Shapero, B.,Lin, X.,Ren, L.,Zhang, L.,Li, D.,Zhou, Z.,Feng, Y.,Sou, C.,Mann, C.J.,Hao, Y.,Sarkar, A.,Hou, J.,Nunnally, C.,Hong, K.,Wang, S.,Ge, X.,Su, B.,Landais, E.,Sok, D.,Zwick, M.B.,He, L.,Zhu, J.,Wilson, I.A.,Shao, Y. A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Sci Adv 2020 6 0 0 7K35 33675814 EQADH-NADH-4-METHYLBENZYL ALCOHOL, p21 2020-09-10 2020-09-23 Plapp, B.V.,Subramanian, R. Alternative binding modes in abortive NADH-alcohol complexes of horse liver alcohol dehydrogenase. Arch.Biochem.Biophys. 2021 701 108825 108825 6V51 32915556 Spin-labeled T4 Lysozyme (9/131FnbY)-(4-Amino-TEMPO) 2019-12-02 2020-10-07 Liu, J.,Cheng, R.,Van Eps, N.,Wang, N.,Morizumi, T.,Ou, W.L.,Klauser, P.C.,Rozovsky, S.,Ernst, O.P.,Wang, L. Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents. J.Am.Chem.Soc. 2020 142 17057 17068 6V51 32915556 Spin-labeled T4 Lysozyme (9/131FnbY)-(4-Amino-TEMPO) 2019-12-02 2020-10-07 Liu, J.,Cheng, R.,Van Eps, N.,Wang, N.,Morizumi, T.,Ou, W.L.,Klauser, P.C.,Rozovsky, S.,Ernst, O.P.,Wang, L. Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents. J.Am.Chem.Soc. 2020 142 17057 17068 6OJE Dimeric structure of LRRK2 GTPase domain 2019-04-11 2020-10-14 Wu, C.X.,Liao, J.,Park, Y.,Hoang, N.C.,Engel, V.A.,Sanishvili, R.,Takagi, Y.,Johnson, S.M.,Wang, M.,Federici, M.,Nichols, R.J.,Cookson, M.R.,Hoang, Q.Q. Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To Be Published 0 0 0 0 6OJF Dimeric structure of LRRK2 GTPase domain 2019-04-11 2020-10-14 Wu, C.X.,Liao, J.,Park, Y.,Hoang, N.C.,Engel, V.A.,Sanishvili, R.,Takagi, Y.,Johnson, S.M.,Wang, M.,Federici, M.,Nichols, R.J.,Cookson, M.R.,Hoang, Q.Q. Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To be published 0 0 0 0 6ULB Sex Hormone-binding globulin mutant E176K in complex with Danazol 2019-10-07 2020-10-21 Round, P.W.,Das, S.,Van Petegem, F.,Hammond, G.L. Structural and biochemical analyses of danazol interactions with sex hormone-binding globulin and effects on androgen action To Be Published 0 0 0 0 6L6R 33097721 Crystal structure of LRP6 E1E2-SOST complex 2019-10-29 2020-10-28 Kim, J.,Han, W.,Park, T.,Kim, E.J.,Bang, I.,Lee, H.S.,Jeong, Y.,Roh, K.,Kim, J.,Kim, J.S.,Kang, C.,Seok, C.,Han, J.-K.,Choi, H.-J. Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nat Commun 2020 11 5357 5357 6UP2 Crystal structure of the murine DHX36 helicase 2019-10-16 2020-10-28 Chuenchor, W.,Jiang, J.,Xiao, T.S. Crystal structure of the murine DHX36 helicase To be published 0 0 0 0 6UP3 Crystal structure of the murine DHX36 helicase in complex with ANP 2019-10-16 2020-10-28 Chuenchor, W.,Jiang, J.,Xiao, T.S. Crystal structure of the murine DHX36 helicase in complex with ANP To be published 0 0 0 0 6UQI Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*) 2019-10-19 2020-10-28 Jung, H.,Lee, S. Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*) To Be Published 0 0 0 0 7K9Z 34135340 Crystal structure of SARS-CoV-2 receptor binding domain in complex with the Fab fragments of neutralizing antibodies 298 and 52 2020-09-29 2020-10-28 Rujas, E.,Kucharska, I.,Tan, Y.Z.,Benlekbir, S.,Cui, H.,Zhao, T.,Wasney, G.A.,Budylowski, P.,Guvenc, F.,Newton, J.C.,Sicard, T.,Semesi, A.,Muthuraman, K.,Nouanesengsy, A.,Aschner, C.B.,Prieto, K.,Bueler, S.A.,Youssef, S.,Liao-Chan, S.,Glanville, J.,Christie-Holmes, N.,Mubareka, S.,Gray-Owen, S.D.,Rubinstein, J.L.,Treanor, B.,Julien, J.P. Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers. Nat Commun 2021 12 3661 3661 6WIM 33089781 CdiB from Escherichia coli 2020-04-10 2020-11-04 Guerin, J.,Botos, I.,Zhang, Z.,Lundquist, K.,Gumbart, J.C.,Buchanan, S.K. Structural insight into toxin secretion by contact dependent growth inhibition transporters. Elife 2020 9 0 0 6USS 32993284 Catalytic S88C mutant of gut microbial sulfatase from Bacteroides fragilis CAG:558 2019-10-28 2020-11-11 Ervin, S.M.,Simpson, J.B.,Gibbs, M.E.,Creekmore, B.C.,Lim, L.,Walton, W.G.,Gharaibeh, R.Z.,Redinbo, M.R. Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases. Biochemistry 2020 59 3939 3950 6UST 32993284 Gut microbial sulfatase from Hungatella hathewayi 2019-10-28 2020-11-11 Ervin, S.M.,Simpson, J.B.,Gibbs, M.E.,Creekmore, B.C.,Lim, L.,Walton, W.G.,Gharaibeh, R.Z.,Redinbo, M.R. Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases. Biochemistry 2020 59 3939 3950 7JOQ 33125059 Structure of NV1 small terminase 2020-08-07 2020-11-11 Niazi, M.,Florio, T.J.,Yang, R.,Lokareddy, R.K.,Swanson, N.A.,Gillilan, R.E.,Cingolani, G. Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation. Nucleic Acids Res. 2020 48 11721 11736 6XJE 33172891 Triuret Hydrolase (TrtA) from Herbaspirillum sp. BH-1 C162S bound with triuret 2020-06-23 2020-11-18 Tassoulas, L.J.,Elias, M.H.,Wackett, L.P. Discovery of an ultraspecific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway. J.Biol.Chem. 2020 296 100055 100055 6UV6 AtmM with bound rebeccamycin analogue 2019-11-01 2020-11-25 Alvarado, S.K.,Miller, M.D.,Wang, Z.,Thorson, J.S.,Phillips Jr., G.N. Structure of AtmM Bound with Glycosylated Indolocarbazole To Be Published 0 0 0 0 6UVQ Crystal structure of Apo AtmM 2019-11-04 2020-11-25 Alvarado, S.K.,Miller, M.D.,Thorson, J.S.,Phillips Jr., G.N. Structure of Apo AtmM To Be Published 0 0 0 0 6UWD Crystal structure of Apo AtmM 2019-11-05 2020-11-25 Alvarado, S.K.,Miller, M.D.,Wang, Z.,Thorson, J.S.,Phillips Jr., G.N. Structure of Apo AtmM To Be Published 0 0 0 0 6UX6 Cruzain covalently bound by a vinylsulfone compound 2019-11-06 2020-11-25 Zhai, X.,Tang, S.,Chenna, B.C.,Meek, T.D.,Sacchettini, J.C. Cruzain covalently bound by a vinylsulfone compound To Be Published 0 0 0 0 6W32 32780017 Crystal structure of Sfh5 2020-03-08 2020-11-25 Khan, D.,Lee, D.,Gulten, G.,Aggarwal, A.,Wofford, J.,Krieger, I.,Tripathi, A.,Patrick, J.W.,Eckert, D.M.,Laganowsky, A.,Sacchettini, J.,Lindahl, P.,Bankaitis, V.A. A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Elife 2020 9 0 0 6OV1 Structure of Staphylococcus aureus RNase P protein mutant with defective mRNA degradation activity 2019-05-06 2020-12-02 Colquhoun, J.M.,Ha, L.,Noinaj, N.,Das, C.,Flaherty, D.P.,Dunman, P.M. Genetic and biochemical characterization of Staphylococcus aureus RnpA To Be Published 0 0 0 0 6X8Q 33253113 Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein PAPP peptide 2020-06-01 2020-12-02 Kucharska, I.,Thai, E.,Srivastava, A.,Rubinstein, J.L.,Pomes, R.,Julien, J.P. Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11. Elife 2020 9 0 0 6X8S 33253113 Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein NAND peptide 2020-06-01 2020-12-02 Kucharska, I.,Thai, E.,Srivastava, A.,Rubinstein, J.L.,Pomes, R.,Julien, J.P. Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11. Elife 2020 9 0 0 6UWA Mouse PKC C1B and C2 domains 2019-11-04 2020-12-09 Igumenova, T. Mouse PKC C1B and C2 domains To Be Published 0 0 0 0 6V5K Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP* 2019-12-04 2020-12-09 Jung, H.,Lee, S. Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP* To Be Published 0 0 0 0 7K6R 32588860 Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to GSK4027 2020-09-21 2020-12-09 Ycas, P.D.,Zahid, H.,Chan, A.,Olson, N.M.,Johnson, J.A.,Talluri, S.K.,Schonbrunn, E.,Pomerantz, W.C.K. New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Org.Biomol.Chem. 2020 18 5174 5182 7K34 33337128 Crystal structure of L-threonine transaldolase from Pseudomonas fluorescens in internal aldimine state 2020-09-10 2020-12-30 Kumar, P.,Meza, A.,Ellis, J.M.,Carlson, G.A.,Bingman, C.A.,Buller, A.R. l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate. Acs Chem.Biol. 2021 16 86 95 6VGM 32686822 Crystal structure of DPO4 with 8-oxoadenine (oxoA) and dTTP* 2020-01-08 2021-01-06 Jung, H.,Lee, S. Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4. Biochem.J. 2020 477 2859 2871 6WK6 33258913 Crystal structure of human polymerase eta complexed with Xanthine containing DNA 2020-04-15 2021-01-06 Jung, H.,Hawkins, M.,Lee, S. Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase. Biochem.J. 2020 477 4797 4810 6VIN 33784495 Crystallographic structure of the circularly permuted human Taspase1 protein 2020-01-13 2021-01-13 Nagaratnam, N.,Delker, S.L.,Jernigan, R.,Edwards, T.E.,Snider, J.,Thifault, D.,Williams, D.,Nannenga, B.L.,Stofega, M.,Sambucetti, L.,Hsieh, J.J.,Flint, A.J.,Fromme, P.,Martin-Garcia, J.M. Structural insights into the function of the catalytically active human Taspase1. Structure 2021 29 873 0 6VMC T4H2 T cell receptor bound to HLA-A2 presenting gp100T2L peptide (ILDQVPFSV) 2020-01-27 2021-01-20 Smith, A.R.,Alonso, J.A.,Ayres, C.M.,Singh, N.K.,Hellman, L.M.,Baker, B.M. Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner Proc.Natl.Acad.Sci.USA 2021 118 0 0 6W5B 33264606 N124D Deamidation Mutant of Human gammaD-Crystallin 2020-03-12 2021-01-20 Guseman, A.J.,Whitley, M.J.,Gonzalez, J.J.,Rathi, N.,Ambarian, M.,Gronenborn, A.M. Assessing the Structures and Interactions of gamma D-Crystallin Deamidation Variants. Structure 2021 29 284 0 6VKP 33881499 Crystal structure of DPO4 extension past 8-oxoadenine (oxoA) and dG 2020-01-21 2021-01-27 Jung, H.,Lee, S. Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4. Biochem.J. 2021 478 1769 1781 6W7B 33127683 K2P2.1 (TREK-1), 0 mM K+ 2020-03-19 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W7C 33127683 K2P2.1 (TREK-1), 1 mM K+ 2020-03-19 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W7D 33127683 K2P2.1 (TREK-1), 10 mM K+ 2020-03-19 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W7E 33127683 K2P2.1 (TREK-1), 30 mM K+ 2020-03-19 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W82 33127683 K2P2.1 (TREK-1), 50 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W83 33127683 K2P2.1 (TREK-1), 100 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W84 33127683 K2P2.1 (TREK-1), 200 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W85 33127683 K2P2.1 (TREK-1):ML335 complex, 200 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W86 33127683 K2P2.1 (TREK-1):ML335 complex, 100 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W87 33127683 K2P2.1 (TREK-1):ML335 complex, 50 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W88 33127683 K2P2.1 (TREK-1):ML335 complex, 30 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W8A 33127683 K2P2.1 (TREK-1):ML335 complex, 10 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W8C 33127683 K2P2.1 (TREK-1):ML335 complex, 1 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6W8F 33127683 K2P2.1 (TREK-1):ML335 complex, 0 mM K+ 2020-03-20 2021-01-27 Lolicato, M.,Natale, A.M.,Abderemane-Ali, F.,Crottes, D.,Capponi, S.,Duman, R.,Wagner, A.,Rosenberg, J.M.,Grabe, M.,Minor Jr., D.L. K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Sci Adv 2020 6 0 0 6VNP Crystal structure of DPO4 extension past 8-oxoadenine (oxoA) and dT 2020-01-29 2021-02-03 Jung, H.,Lee, S. Crystal structure of DPO4 extension past 8-oxoadenine (oxoA) and dT To Be Published 0 0 0 0 6VYA 36223664 Crystal structure of NotF in complex with brevianamide F and DMSPP 2020-02-25 2021-02-03 Kelly, S.P.,Shende, V.V.,Flynn, A.R.,Dan, Q.,Ye, Y.,Smith, J.L.,Tsukamoto, S.,Sigman, M.S.,Sherman, D.H. Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. J.Am.Chem.Soc. 2022 144 19326 19336 6X1S 33547238 Structure of pHis Fab (SC1-1) in complex with pHis mimetic peptide 2020-05-19 2021-02-03 Kalagiri, R.,Stanfield, R.L.,Meisenhelder, J.,La Clair, J.J.,Fuhs, S.R.,Wilson, I.A.,Hunter, T. Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies. 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Structure 2021 29 598 0 7JMR 33542397 Crystal structure of the pea pathogenicity protein 2 from Madurella mycetomatis 2020-08-02 2021-02-17 Zeug, M.,Markovic, N.,Iancu, C.V.,Tripp, J.,Oreb, M.,Choe, J.Y. Crystal structures of non-oxidative decarboxylases reveal a new mechanism of action with a catalytic dyad and structural twists. Sci Rep 2021 11 3056 3056 7JMV 33542397 Crystal structure of the pea pathogenicity protein 2 from Madurella mycetomatis complexed with 4-nitrocatechol 2020-08-03 2021-02-17 Zeug, M.,Markovic, N.,Iancu, C.V.,Tripp, J.,Oreb, M.,Choe, J.Y. Crystal structures of non-oxidative decarboxylases reveal a new mechanism of action with a catalytic dyad and structural twists. Sci Rep 2021 11 3056 3056 7KV1 33587952 Surface glycan-binding protein A from Bacteroides uniformis 2020-11-26 2021-02-17 Tamura, K.,Dejean, G.,Van Petegem, F.,Brumer, H. Distinct protein architectures mediate species-specific beta-glucan binding and metabolism in the human gut microbiota. 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Nat Commun 2021 12 3305 3305 6WJL 34337560 Crystal structure of Glypican-2 core protein in complex with D3 Fab 2020-04-14 2021-04-21 Raman, S.,Buongervino, S.N.,Lane, M.V.,Zhelev, D.V.,Zhu, Z.,Cui, H.,Martinez, B.,Martinez, D.,Wang, Y.,Upton, K.,Patel, K.,Rathi, K.S.,Navia, C.T.,Harmon, D.B.,Li, Y.,Pawel, B.,Dimitrov, D.S.,Maris, J.M.,Julien, J.P.,Bosse, K.R. A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med 2021 2 100344 100344 6WJU Fab Fragment of Anti-human LAG3 antibody (4A10) 2020-04-14 2021-04-21 Agnihotri, P.,Mishra, A.K.,Mariuzza, R.A. Fab Fragment of Anti-human LAG3 antibody To Be Published 0 0 0 0 6WKL Fab Fragment of Anti-human LAG3 antibody (BAP050) 2020-04-16 2021-04-21 Agnihotri, P.,Mishra, A.K.,Mariuzza, R.A. 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Biochemistry 2021 60 1776 1786 6XAF 1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H 2020-06-04 2021-06-09 Wu, C.X.,Liao, J.,Park, Y.,Hoang, N.C.,Engel, V.A.,Sanishvili, R.,Takagi, Y.,Johnson, S.M.,Wang, M.,Federici, M.,Nichols, R.J.,Cookson, M.R.,Hoang, Q.Q. Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To be Published 0 0 0 0 6XBO 34081697 X-ray crystal structure of the mouse CMP-Sialic acid transporter in complex with 5-methyl CMP 2020-06-06 2021-06-09 Ahuja, S.,Cahill, J.,Hartfield, K.,Whorton, M.R. Inhibition of CMP-sialic acid transport by endogenous 5-methyl CMP. 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Nat Commun 2021 12 4671 4671 7RK0 34409984 Crystal structure of Thermovibrio ammonificans THI4 2021-07-21 2021-09-01 Joshi, J.,Li, Q.,Garcia-Garcia, J.D.,Leong, B.J.,Hu, Y.,Bruner, S.D.,Hanson, A.D. Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases. Biochem.J. 2021 478 3265 3279 7RAG 34570752 Structure of the CwlD amidase from Clostridioides difficile in complex with the GerS lipoprotein 2021-07-01 2021-09-08 Alves Feliciano, C.,Eckenroth, B.E.,Diaz, O.R.,Doublie, S.,Shen, A. A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation. Plos Genet. 2021 17 0 0 7MJZ 34526715 The structure of MiaB with pentasulfide bridge 2021-04-20 2021-09-15 Esakova, O.A.,Grove, T.L.,Yennawar, N.H.,Arcinas, A.J.,Wang, B.,Krebs, C.,Almo, S.C.,Booker, S.J. Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB. 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Viruses 2022 14 363 0 7MMS Crystal Structure of the Class Ie Ribonucleotide Reductase Beta-NrdI complex from Aerococcus urinae in Semiquinone Form with Cu(I) bound 2021-04-30 2022-05-04 Palowitch, G.M.,Boal, A.K. Ribonucleotide Reductase To be published 0 0 0 0 7SIT 35452285 Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m 2021-10-14 2022-05-04 Reddi, R.,Matulef, K.,Riederer, E.A.,Whorton, M.R.,Valiyaveetil, F.I. Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel. Sci Adv 2022 8 0 0 7SIZ 35452285 C-type inactivation in a voltage gated K+ channel 2021-10-15 2022-05-04 Reddi, R.,Matulef, K.,Riederer, E.A.,Whorton, M.R.,Valiyaveetil, F.I. Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel. Sci Adv 2022 8 0 0 7T6W 35476408 Crystal structure of Chaetomium Glucosidase I (apo) 2021-12-14 2022-05-04 Karade, S.S.,Kolesnikov, A.,Treston, A.M.,Mariuzza, R.A. 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Cell 2022 185 3533 0 7MNT 35679405 Crystal Structure of the ZnF5 or ZnF6 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP 2021-05-01 2022-06-15 Bley, C.J.,Nie, S.,Mobbs, G.W.,Petrovic, S.,Gres, A.T.,Liu, X.,Mukherjee, S.,Harvey, S.,Huber, F.M.,Lin, D.H.,Brown, B.,Tang, A.W.,Rundlet, E.J.,Correia, A.R.,Chen, S.,Regmi, S.G.,Stevens, T.A.,Jette, C.A.,Dasso, M.,Patke, A.,Palazzo, A.F.,Kossiakoff, A.A.,Hoelz, A. Architecture of the cytoplasmic face of the nuclear pore. Science 2022 376 0 0 7MO0 35679405 Crystal Structure of Nucleoporin NUP50 Ran-Binding Domain in Complex with Ran-GPPNHP 2021-05-01 2022-06-15 Bley, C.J.,Nie, S.,Mobbs, G.W.,Petrovic, S.,Gres, A.T.,Liu, X.,Mukherjee, S.,Harvey, S.,Huber, F.M.,Lin, D.H.,Brown, B.,Tang, A.W.,Rundlet, E.J.,Correia, A.R.,Chen, S.,Regmi, S.G.,Stevens, T.A.,Jette, C.A.,Dasso, M.,Patke, A.,Palazzo, A.F.,Kossiakoff, A.A.,Hoelz, A. Architecture of the cytoplasmic face of the nuclear pore. Science 2022 376 0 0 7SMC 35716663 p107 pocket domain complexed with ARID4A peptide 2021-10-25 2022-06-29 Putta, S.,Alvarez, L.,Ludtke, S.,Sehr, P.,Muller, G.A.,Fernandez, S.M.,Tripathi, S.,Lewis, J.,Gibson, T.J.,Chemes, L.B.,Rubin, S.M. Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure 2022 30 1340 0 7SMD 35716663 p107 pocket domain complexed with EID1 peptide 2021-10-25 2022-06-29 Putta, S.,Alvarez, L.,Ludtke, S.,Sehr, P.,Muller, G.A.,Fernandez, S.M.,Tripathi, S.,Lewis, J.,Gibson, T.J.,Chemes, L.B.,Rubin, S.M. Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure 2022 30 1340 0 7SMF 35716663 p107 pocket domain complexed with mutated HDAC1-3X peptide 2021-10-25 2022-06-29 Putta, S.,Alvarez, L.,Ludtke, S.,Sehr, P.,Muller, G.A.,Fernandez, S.M.,Tripathi, S.,Lewis, J.,Gibson, T.J.,Chemes, L.B.,Rubin, S.M. 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J.Med.Chem. 2023 66 2744 2760 7R7E Synechococcus Olefin Synthase FAAL domain in complex with AMP and pyrophosphate 2021-06-24 2022-07-06 Sikkema, A.P.,Sturgis, R.M.,Gerwick, W.H.,Sherman, D.H.,Smith, J.L. An electrostatic fatty acid selection mechanism by the Olefin Synthase FAAL domain from Synechococcus sp. PCC7002 To Be Published 0 0 0 0 7R7F Synechococcus Olefin Synthase FAAL domain R336A in complex with stearoyl adenylate and pyrophosphate 2021-06-24 2022-07-06 Sikkema, A.P.,Sturgis, R.M.,Gerwick, W.H.,Sherman, D.H.,Smith, J.L. An electrostatic fatty acid selection mechanism by the Olefin Synthase FAAL domain from Synechococcus sp. PCC7002 To Be Published 0 0 0 0 7RA7 Crystal structure of rabbit anti-HIV Fab 11A 2021-06-30 2022-07-06 Ozorowski, G.,Cottrell, C.A.,Oyen, D.,de Val, N.,Copps, J.,Scaring, N.,Polveroni, T.M.,Wilson, I.A.,Ward, A.B. 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Proc.Natl.Acad.Sci.USA 2022 119 0 0 8CWU 35738279 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing nanobody 1-21 2022-05-19 2022-07-06 Xiang, Y.,Huang, W.,Liu, H.,Sang, Z.,Nambulli, S.,Tubiana, J.,Williams Jr., K.L.,Duprex, W.P.,Schneidman-Duhovny, D.,Wilson, I.A.,Taylor, D.J.,Shi, Y. Superimmunity by pan-sarbecovirus nanobodies. Cell Rep 2022 39 111004 111004 8CWV 35738279 Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with a cross-neutralizing nanobody 2-31 and a human antibody CC12.1 Fab 2022-05-19 2022-07-06 Xiang, Y.,Huang, W.,Liu, H.,Sang, Z.,Nambulli, S.,Tubiana, J.,Williams Jr., K.L.,Duprex, W.P.,Schneidman-Duhovny, D.,Wilson, I.A.,Taylor, D.J.,Shi, Y. Superimmunity by pan-sarbecovirus nanobodies. 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Microbial beta-glucuronidases drive human periodontal disease etiology. Sci Adv 2023 9 0 0 8FXV 37279271 Crystal structure of human proTGF-beta2 in complex with Nb18 2023-01-25 2023-06-21 Le, V.Q.,Zhao, B.,Ramesh, S.,Toohey, C.,DeCosta, A.,Mintseris, J.,Liu, X.,Gygi, S.,Springer, T.A. A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA 2023 120 0 0 8DJ8 Crystal Structure of Calgreen 1 protein 2022-06-30 2023-07-05 Nguyen, H.B.,Hung, L.-W.,Waldo, G.S. Structure and Function of Engineered Variants of GFP-type Green Fluorescent protein from Corynactis californica (tentative) To Be Published 0 0 0 0 8FIB 37339230 Crystal Structure of Erwinia tracheiphila CYP114 2022-12-16 2023-07-05 Nagel, R.,Alexander, L.E.,Stewart Jr., C.E.,Peters, R.J. Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis. 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Structure of ADP-ribose-bound Drosophila macrodomain CG3568 To Be Published 0 0 0 0 8EL2 37531329 SARS-CoV-2 RBD bound to neutralizing antibody Fab ICO-hu23 2022-09-22 2023-07-19 Hermet, P.,Delache, B.,Herate, C.,Wolf, E.,Kivi, G.,Juronen, E.,Mumm, K.,Zusinaite, E.,Kainov, D.,Sankovski, E.,Virumae, K.,Planken, A.,Merits, A.,Besaw, J.E.,Yee, A.W.,Morizumi, T.,Kim, K.,Kuo, A.,Berriche, A.,Dereuddre-Bosquet, N.,Sconosciuti, Q.,Naninck, T.,Relouzat, F.,Cavarelli, M.,Ustav, M.,Wilson, D.,Ernst, O.P.,Mannik, A.,LeGrand, R.,Ustav Jr., M. Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates. Plos Pathog. 2023 19 0 0 8FWY 37418678 Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to the dead-end complex xanthine and pyrophosphate 2023-01-23 2023-07-19 Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry 2023 62 2182 2201 8FWZ 37418678 Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Hydroxypropyl-Lin-ImmH Phosphonate 2023-01-23 2023-07-19 Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry 2023 62 2182 2201 8FX0 37418678 Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (S)-SerMe-ImmH Phosphonate 2023-01-23 2023-07-19 Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry 2023 62 2182 2201 8FX1 37418678 Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (R)-SerMe-ImmH Phosphonate 2023-01-23 2023-07-19 Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry 2023 62 2182 2201 8FX2 37418678 Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-HP 2023-01-23 2023-07-19 Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry 2023 62 2182 2201 8FX3 37418678 Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-GP, showing the structure of the complete active site in its open conformation 2023-01-23 2023-07-19 Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry 2023 62 2182 2201 8DTQ 37967733 Crystal Structure of Staphylococcus aureus pSK41 Cop 2022-07-26 2023-08-02 Sarosh, A.,Kwong, S.M.,Jensen, S.O.,Northern, F.,Walton, W.G.,Eakes, T.C.,Redinbo, M.R.,Firth, N.,McLaughlin, K.J. pSK41/pGO1-family conjugative plasmids of Staphylococcus aureus encode a cryptic repressor of replication. Plasmid 2023 128 102708 102708 8EQA 37506693 Crystal structure of human anti-N1 neuraminidase 2H08 Fab 2022-10-07 2023-08-09 Hansen, L.,McMahon, M.,Turner, H.L.,Zhu, X.,Turner, J.S.,Ozorowski, G.,Stadlbauer, D.,Vahokoski, J.,Schmitz, A.J.,Rizk, A.A.,Alsoussi, W.B.,Strohmeier, S.,Yu, W.,Choreno-Parra, J.A.,Jimenez-Alvarez, L.,Cruz-Lagunas, A.,Zuniga, J.,Mudd, P.A.,Cox, R.J.,Wilson, I.A.,Ward, A.B.,Ellebedy, A.H.,Krammer, F. Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo. Immunity 2023 56 1927 0 8EQC 37506693 Crystal structure of human anti-N1 neuraminidase 3H03 Fab 2022-10-07 2023-08-09 Hansen, L.,McMahon, M.,Turner, H.L.,Zhu, X.,Turner, J.S.,Ozorowski, G.,Stadlbauer, D.,Vahokoski, J.,Schmitz, A.J.,Rizk, A.A.,Alsoussi, W.B.,Strohmeier, S.,Yu, W.,Choreno-Parra, J.A.,Jimenez-Alvarez, L.,Cruz-Lagunas, A.,Zuniga, J.,Mudd, P.A.,Cox, R.J.,Wilson, I.A.,Ward, A.B.,Ellebedy, A.H.,Krammer, F. Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo. Immunity 2023 56 1927 0 8S93 38189455 Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase 2023-03-27 2023-08-16 Lin, D.Y.,Kueffer, L.E.,Juneja, P.,Wales, T.E.,Engen, J.R.,Andreotti, A.H. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife 2024 12 0 0 8TFR 37534714 Apo Fab from C10-S66K antibody 2023-07-11 2023-08-16 Eubanks, L.M.,Pholcharee, T.,Oyen, D.,Natori, Y.,Zhou, B.,Wilson, I.A.,Janda, K.D. An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. Acs Chem Neurosci 2023 14 2849 2856 8F0Y 37384723 Lipocalin-like Milk protein-1 2022-11-04 2023-08-23 Santhakumari, P.R.,Dhanabalan, K.,Virani, S.,Hopf-Jannasch, A.S.,Benoit, J.B.,Chopra, G.,Subramanian, R. Variability in phenylalanine side chain conformations facilitates broad substrate tolerance of fatty acid binding in cockroach milk proteins. Plos One 2023 18 0 0 8SBG 37633277 Crystal structure of B. theta tryptophanase in holo form 2023-04-03 2023-08-23 Graboski, A.L.,Kowalewski, M.E.,Simpson, J.B.,Cao, X.,Ha, M.,Zhang, J.,Walton, W.G.,Flaherty, D.P.,Redinbo, M.R. Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chem Biol 2023 30 1402 0 8SIJ 37633277 Crystal structure of F. varium tryptophanase 2023-04-16 2023-08-23 Graboski, A.L.,Kowalewski, M.E.,Simpson, J.B.,Cao, X.,Ha, M.,Zhang, J.,Walton, W.G.,Flaherty, D.P.,Redinbo, M.R. Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chem Biol 2023 30 1402 0 8SL7 37633277 Butyricicoccus sp. BIOML-A1 tryptophanase complex with (3S) ALG-05 2023-04-21 2023-08-23 Graboski, A.L.,Kowalewski, M.E.,Simpson, J.B.,Cao, X.,Ha, M.,Zhang, J.,Walton, W.G.,Flaherty, D.P.,Redinbo, M.R. Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chem Biol 2023 30 1402 0 8FY7 37595260 SARS-CoV-2 main protease in complex with covalent inhibitor 2023-01-25 2023-08-30 Ngo, C.,Fried, W.,Aliyari, S.,Feng, J.,Qin, C.,Zhang, S.,Yang, H.,Shanaa, J.,Feng, P.,Cheng, G.,Chen, X.S.,Zhang, C. Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. J.Med.Chem. 2023 66 12237 12248 8FWH 37619561 Crystal structure of bivalent antibody Fab fragment of Anti-human LAG3 (22D2) 2023-01-22 2023-09-06 Mishra, A.K.,Shahid, S.,Karade, S.S.,Agnihotri, P.,Kolesnikov, A.,Hasan, S.S.,Mariuzza, R.A. CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure 2023 31 1149 0 8ECZ 37722054 Bovine Fab 4C1 2022-09-02 2023-09-20 Huang, R.,Warner Jenkins, G.,Kim, Y.,Stanfield, R.L.,Singh, A.,Martinez-Yamout, M.,Kroon, G.J.,Torres, J.L.,Jackson, A.M.,Kelley, A.,Shaabani, N.,Zeng, B.,Bacica, M.,Chen, W.,Warner, C.,Radoicic, J.,Joh, J.,Dinali Perera, K.,Sang, H.,Kim, T.,Yao, J.,Zhao, F.,Sok, D.,Burton, D.R.,Allen, J.,Harriman, W.,Mwangi, W.,Chung, D.,Teijaro, J.R.,Ward, A.B.,Dyson, H.J.,Wright, P.E.,Wilson, I.A.,Chang, K.O.,McGregor, D.,Smider, V.V. The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA 2023 120 0 0 8G96 Adenylation domain structure from NRPS-like Delta-Poly-L-Ornithine synthetase (L-Ornithine bound) 2023-02-21 2023-10-04 Patel, K.D.,Gulick, A.M. Structural and functional insights into delta-poly-L-ornithine polymer biosynthesis from Acinetobacter baumannii Commun Biol 2023 6 982 0 8G98 Adenylation domain structure from NRPS-like Delta-Poly-L-Ornithine synthetase (L-Lysine bound) 2023-02-21 2023-10-04 Patel, K.D.,Gulick, A.M. Structural and functional insights into delta-poly-L-ornithine polymer biosynthesis from Acinetobacter baumannii Commun Biol 2023 6 982 0 8T1Z 37747935 Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) Bound to Neu5Ac (NANA) 2023-06-05 2023-10-04 Clark, N.D.,Pham, C.,Kurniyati, K.,Sze, C.W.,Coleman, L.,Fu, Q.,Zhang, S.,Malkowski, M.G.,Li, C. Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors. Plos Pathog. 2023 19 0 0 8T26 37747935 Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 3'-Sialyllactose (only Neu5Ac visible) 2023-06-05 2023-10-04 Clark, N.D.,Pham, C.,Kurniyati, K.,Sze, C.W.,Coleman, L.,Fu, Q.,Zhang, S.,Malkowski, M.G.,Li, C. Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors. Plos Pathog. 2023 19 0 0 8T27 37747935 Crystal Structure of Porphyromonas gingivalis Sialidase (PG_0352) D219A mutant bound to 6'-Sialyllactose (only Neu5Ac visible) 2023-06-05 2023-10-04 Clark, N.D.,Pham, C.,Kurniyati, K.,Sze, C.W.,Coleman, L.,Fu, Q.,Zhang, S.,Malkowski, M.G.,Li, C. Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors. Plos Pathog. 2023 19 0 0 8E0G 37817141 Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 2022-08-09 2023-10-18 Munro, T.A. Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol. 2023 21 213 213 8G1B 37804505 Crystal structure of polyreactive 2G02 human Fab 2023-02-01 2023-10-18 Borowska, M.T.,Boughter, C.T.,Bunker, J.J.,Guthmiller, J.J.,Wilson, P.C.,Roux, B.,Bendelac, A.,Adams, E.J. Biochemical and biophysical characterization of natural polyreactivity in antibodies. Cell Rep 2023 42 113190 113190 8EHZ 37914719 Crystal structure of the STUB1 TPR domain in complex with H317, a Helicon Polypeptide 2022-09-14 2023-10-25 Tokareva, O.S.,Li, K.,Travaline, T.L.,Thomson, T.M.,Swiecicki, J.M.,Moussa, M.,Ramirez, J.D.,Litchman, S.,Verdine, G.L.,McGee, J.H. Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun 2023 14 6992 6992 8EI0 37914719 Crystal structure of the STUB1 TPR domain in complex with H318, a Helicon Polypeptide 2022-09-14 2023-10-25 Tokareva, O.S.,Li, K.,Travaline, T.L.,Thomson, T.M.,Swiecicki, J.M.,Moussa, M.,Ramirez, J.D.,Litchman, S.,Verdine, G.L.,McGee, J.H. Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun 2023 14 6992 6992 8EI5 37914719 Crystal structure of the WWP2 HECT domain in complex with H301, a Helicon Polypeptide 2022-09-14 2023-10-25 Tokareva, O.S.,Li, K.,Travaline, T.L.,Thomson, T.M.,Swiecicki, J.M.,Moussa, M.,Ramirez, J.D.,Litchman, S.,Verdine, G.L.,McGee, J.H. Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun 2023 14 6992 6992 8EI7 37914719 Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide 2022-09-14 2023-10-25 Tokareva, O.S.,Li, K.,Travaline, T.L.,Thomson, T.M.,Swiecicki, J.M.,Moussa, M.,Ramirez, J.D.,Litchman, S.,Verdine, G.L.,McGee, J.H. Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun 2023 14 6992 6992 8ESG Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound 2022-10-14 2023-11-01 Walker, M.E.,Redinbo, M.R. Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published 0 0 0 0 8ESI Bile Salt Hydrolase from B. longum with covalent inhibitor bound 2022-10-14 2023-11-01 Walker, M.E.,Lim, L.,Redinbo, M.R. Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published 0 0 0 0 8ETE Bile Salt Hydrolase from B. longum with covalent inhibitor bound 2022-10-17 2023-11-01 Walker, M.E.,Redinbo, M.R. Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published 0 0 0 0 8ETF Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound 2022-10-17 2023-11-01 Walker, M.E.,Redinbo, M.R. Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published 0 0 0 0 8ETK Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe 2022-10-17 2023-11-01 Walker, M.E.,Grundy, M.K.,Redinbo, M.R. Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published 0 0 0 0 8F9T 38007690 Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NPDP peptide 2022-11-24 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FA6 38007690 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein DND peptide 2022-11-25 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FA7 38007690 Crystal structure of Ky15.11 Fab in complex with circumsporozoite protein KQPA peptide 2022-11-25 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FA8 38007690 Crystal structure of Ky15.11 Fab in complex with circumsporozoite protein NDN peptide 2022-11-25 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FA9 38007690 Crystal structure of Ky15.5 Fab in complex with circumsporozoite protein NPDP peptide 2022-11-25 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FAN 38007690 Crystal structure of Ky15.1 Fab in complex with circumsporozoite protein KQPA peptide 2022-11-28 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FAS 38007690 Crystal structure of Ky230 Fab in complex with circumsporozoite protein NANP5 peptide 2022-11-28 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FAT 38007690 Crystal structure of Ky224 Fab in complex with circumsporozoite protein NPDP peptide 2022-11-28 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FB6 38007690 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein KQPA peptide 2022-11-29 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FB7 38007690 Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein NPDP peptide 2022-11-29 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8FDC 38007690 Crystal structure of Ky311 Fab in complex with circumsporozoite protein KQPA peptide 2022-12-02 2023-11-01 Thai, E.,Murugan, R.,Binter, S.,Burn Aschner, C.,Prieto, K.,Kassardjian, A.,Obraztsova, A.S.,Kang, R.W.,Flores-Garcia, Y.,Mathis-Torres, S.,Li, K.,Horn, G.Q.,Huntwork, R.H.C.,Bolscher, J.M.,de Bruijni, M.H.C.,Sauerwein, R.,Dennison, S.M.,Tomaras, G.D.,Zavala, F.,Kellam, P.,Wardemann, H.,Julien, J.P. Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Cell Rep 2023 42 113330 113330 8TH9 37971311 Structure of mammalian NEIL2 from Monodelphis domestica in complex with THF-containing DNA 2023-07-14 2023-11-01 Eckenroth, B.E.,Bumgarner, J.D.,Matsumoto-Elliott, O.,David, S.S.,Doublie, S. Structural and biochemical insights into NEIL2's preference for abasic sites. Nucleic Acids Res. 2023 51 12508 12521 8TFN Structure of anti-TCRvbeta6-5 antibody in complex with the cognate TCR 2023-07-11 2023-11-08 Vantourout, P.,Eum, J.,Poole, M.C.,Hayday, T.S.,Laing, A.G.,Hussain, K.,Nuamah, R.,Kannambath, S.,Moisan, J.,Stoop, A.,Battaglia, S.,Servatalab, R.,Hsu, J.,Bayliffe, A.,Katragadda, M.,Hayday, A.C. Structure of anti-TCRvbeta6-5 antibody in complex with the cognate TCR To Be Published 0 0 0 0 8EWT Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe 2022-10-24 2023-11-15 Walker, M.E.,Redinbo, M.R. Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published 0 0 0 0 8TN8 37910165 Crystal structure of the murine astrovirus capsid spike at 1.75 A 2023-08-01 2023-11-15 Lanning, S.,Pedicino, N.,Haley, D.J.,Hernandez, S.,Cortez, V.,DuBois, R.M. Structure and immunogenicity of the murine astrovirus capsid spike. J.Gen.Virol. 2023 104 0 0 8U8Q 37926680 V290N/S292F Streptomyces coelicolor Laccase 2023-09-18 2023-11-15 Wang, J.X.,Vilbert, A.C.,Cui, C.,Mirts, E.N.,Williams, L.H.,Kim, W.,Jessie Zhang, Y.,Lu, Y. Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase from Streptomyces coelicolor through Secondary Coordination Sphere Mutations. Angew.Chem.Int.Ed.Engl. 2023 62 0 0 8T1S 37799586 Structure of the alpha-N-methyltransferase (SonM) and RiPP precursor (SonA with QSY deletion) heteromeric complex (bound to SAH) 2023-06-03 2023-11-22 Crone, K.K.,Jomori, T.,Miller, F.S.,Gralnick, J.A.,Elias, M.H.,Freeman, M.F. RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin alpha- N -methylated peptide natural product. Rsc Chem Biol 2023 4 804 816 8T1T 37799586 Structure of the alpha-N-methyltransferase (SonM) and RiPP precursor (SonA with QSY deletion) heteromeric complex (bound to SAM) 2023-06-03 2023-11-22 Crone, K.K.,Jomori, T.,Miller, F.S.,Gralnick, J.A.,Elias, M.H.,Freeman, M.F. RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin alpha- N -methylated peptide natural product. Rsc Chem Biol 2023 4 804 816 8T5P 38005906 SARS-CoV-2 ORF3a peptide in complex with TRAF3 TRAF domain 2023-06-14 2023-11-29 Busscher, B.M.,Befekadu, H.B.,Liu, Z.,Xiao, T.S. SARS-CoV-2 ORF3a-Mediated NF-kappa B Activation Is Not Dependent on TRAF-Binding Sequence. Viruses 2023 15 0 0 8GM6 38013090 Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Selenomethionine) 2023-03-24 2023-12-06 Caffrey, P.J.,Eckenroth, B.E.,Burkhart, B.W.,Zatopek, K.M.,McClung, C.M.,Santangelo, T.J.,Doublie, S.,Gardner, A.F. Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem. 2023 300 105503 105503 8GM7 38013090 Structure of apurinic/apyrimidinic DNA Lyase TK0353 from Thermococcus kodakarensis (Native Crystal Form) 2023-03-24 2023-12-06 Caffrey, P.J.,Eckenroth, B.E.,Burkhart, B.W.,Zatopek, K.M.,McClung, C.M.,Santangelo, T.J.,Doublie, S.,Gardner, A.F. Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem. 2023 300 105503 105503 8SYJ 38013090 Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Iodide crystal form) 2023-05-25 2023-12-06 Caffrey, P.J.,Eckenroth, B.E.,Burkhart, B.W.,Zatopek, K.M.,McClung, C.M.,Santangelo, T.J.,Doublie, S.,Gardner, A.F. Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold. J.Biol.Chem. 2023 300 105503 105503 8TUI 38185735 Crystal structure of Fab-Lirilumab bound to KIR2DL3 2023-08-16 2023-12-06 Lorig-Roach, N.,Harpell, N.M.,DuBois, R.M. Structural basis for the activity and specificity of the immune checkpoint inhibitor lirilumab. Sci Rep 2024 14 742 742 8BTT 38493148 Structure of human RTCB 2022-11-30 2023-12-13 Gerber, J.L.,Morales Guzman, S.I.,Worf, L.,Hubbe, P.,Kopp, J.,Peschek, J. Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease. Nat Commun 2024 15 2378 2378 8D01 The domain-swaped dimer of the HIV-1 CD4bs targeting antibody 21N13 2022-05-25 2023-12-13 Xian, Y.,Wilson, A. Structural and Antigenic Characterization of B Cell Mosaic Env Trimers To Be Published 0 0 0 0 8D50 Crystal Structure of Mosaic HIV-1 Envelope (MosM3.1) in Complex with antibodies PGT124 and 35O22 at 4.3 Angstrom 2022-06-03 2023-12-13 Xian, Y.,Wilson, A. Structural and Antigenic Characterization of B Cell Mosaic Env Trimers To Be Published 0 0 0 0 8FAO Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound 2022-11-28 2023-12-13 Grundy, M.K.,Walker, M.E.,Redinbo, M.R. Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published 0 0 0 0 8UAP 38016297 Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441 2023-09-21 2023-12-13 Chen, Y.,Sonawane, A.,Manda, R.,Gadi, R.K.,Tesmer, J.J.G.,Ghosh, A.K. Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes. Eur.J.Med.Chem. 2023 264 115931 115931 8TYJ Crystal structure of SARS-CoV-2 nsp10/nsp16 complex with bound SAH 2023-08-25 2024-01-24 Patel, K.P.,Bruner, S.D. Crystal structure of SARS-CoV-2 nsp10/nsp16 complex with bound SAH To Be Published 0 0 0 0 8FUP Bromodomain of CBP liganded with BMS-536924 and CCS-1477 2023-01-18 2024-02-07 Schonbrunn, E.,Bikowitz, M. Structural basis of CBP and EP300 interaction with kinase inhibitors To Be Published 0 0 0 0 8FXN Bromodomain of CBP liganded with iCBP7 2023-01-25 2024-02-07 Schonbrunn, E.,Bikowitz, M. Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To be published 0 0 0 0 8GEN E. eligens beta-glucuronidase bound to UNC10201652-glucuronide 2023-03-07 2024-02-14 Simpson, J.B.,Redinbo, M.R. Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes To Be Published 0 0 0 0 8GEQ E. eligens beta-glucuronidase bound to ceritinib-glucuronide 2023-03-07 2024-02-14 Simpson, J.B.,Redinbo, M.R. Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes To Be Published 0 0 0 0 8GES R. hominis 2 beta-glucuronidase bound to UNC10201652-glucuronide 2023-03-07 2024-02-14 Simpson, J.B.,Redinbo, M.R. Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes To Be Published 0 0 0 0 8UFO 38416796 Crystal Structure of Gastrointestinal HAstV VA1 capsid spike domain at 1.46 A resolution 2023-10-04 2024-02-14 Ghosh, A.,Delgado-Cunningham, K.,Lopez, T.,Green, K.,Arias, C.F.,DuBois, R.M. Structure and antigenicity of the divergent human astrovirus VA1 capsid spike. Plos Pathog. 2024 20 0 0 8GA2 Bromodomain of CBP liganded with inhibitor iCBP5 2023-02-22 2024-02-28 Schonbrunn, E.,Bikowitz, M. Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition To be published 0 0 0 0 8SNF 38408229 Crystal structure of metformin hydrolase (MfmAB) from Pseudomonas mendocina sp. MET-2 with Ni2+2 bound 2023-04-27 2024-03-06 Tassoulas, L.J.,Rankin, J.A.,Elias, M.H.,Wackett, L.P. Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. Proc.Natl.Acad.Sci.USA 2024 121 0 0 8SNK 38408229 Crystal structure of metformin hydrolase (MfmAB) from Pseudomonas mendocina sp. MET-2 mutant (MfmA/D188N) 2023-04-27 2024-03-06 Tassoulas, L.J.,Rankin, J.A.,Elias, M.H.,Wackett, L.P. Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. Proc.Natl.Acad.Sci.USA 2024 121 0 0 8V05 38537643 Crystal structure of mouse PLD3 2023-11-17 2024-03-13 Yuan, M.,Peng, L.,Huang, D.,Gavin, A.,Luan, F.,Tran, J.,Feng, Z.,Zhu, X.,Matteson, J.,Wilson, I.A.,Nemazee, D. Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4. Structure 2024 0 0 0 8V06 38537643 Crystal structure of mouse PLD3 co-crystallized with 5'Pi-ssDNA for 9 days 2023-11-17 2024-03-13 Yuan, M.,Peng, L.,Huang, D.,Gavin, A.,Luan, F.,Tran, J.,Feng, Z.,Zhu, X.,Matteson, J.,Wilson, I.A.,Nemazee, D. Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4. Structure 2024 0 0 0 8V08 38537643 Crystal structure of human PLD4 co-crystallized with 5'Pi-ssDNA 2023-11-17 2024-03-13 Yuan, M.,Peng, L.,Huang, D.,Gavin, A.,Luan, F.,Tran, J.,Feng, Z.,Zhu, X.,Matteson, J.,Wilson, I.A.,Nemazee, D. Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4. Structure 2024 0 0 0 8GDN 38327055 Structure of PmHMGR bound to mevalonate, CoA and NAD. 2023-03-06 2024-03-20 Purohit, V.,Steussy, C.N.,Rosales, A.R.,Critchelow, C.J.,Schmidt, T.,Helquist, P.,Wiest, O.,Mesecar, A.,Cohen, A.E.,Stauffacher, C.V. pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J. 2024 123 622 637 8GEO E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide 2023-03-07 2024-03-20 Simpson, J.B.,Redinbo, M.R. Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes To Be Published 0 0 0 0 8GER E. eligens beta-glucuronidase bound to norquetiapine-glucuronide 2023-03-07 2024-03-20 Simpson, J.B.,Redinbo, M.R. Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes To Be Published 0 0 0 0 8GET R. hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide 2023-03-07 2024-03-20 Simpson, J.B.,Redinbo, M.R. Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes To Be Published 0 0 0 0 8VLQ 38327055 Structure of PmHMGR bound to mevalonate, CoA and NAD 5 minutes after reaction initiation at pH 9 2024-01-12 2024-03-20 Purohit, V.,Steussy, C.N.,Rosales, A.R.,Critchelow, C.J.,Schmidt, T.,Helquist, P.,Wiest, O.,Mesecar, A.,Cohen, A.E.,Stauffacher, C.V. pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J. 2024 123 622 637 8SO5 38520282 Crystal structure of the engineered quorum quenching acylase MacQ variant M1 - acylated form 2023-04-28 2024-04-03 Sompiyachoke, K.,Elias, M.H. Engineering quorum quenching acylases with improved kinetic and biochemical properties. Protein Sci. 2024 33 0 0 8UUU SARS-Cov-2 papain-like protease (PLpro) with inhibitor Jun12162 2023-11-02 2024-04-03 Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J. Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model Science 2024 383 1434 1440 8UUV SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12197 2023-11-02 2024-04-03 Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J. Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model Science 2024 383 1434 1440 8UUW SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12145 2023-11-02 2024-04-03 Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J. Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model Science 2024 383 1434 1440 8UUY SARS-CoV-2 papain-like protease (PLpro) complex with inhibitor Jun12129 2023-11-02 2024-04-03 Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J. Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model Science 2024 383 1434 1440 8UVM SARS-CoV-2 papain-like protease (PLpro) complex with covalent inhibitor Jun11313 2023-11-03 2024-04-03 Tan, B.,Zhang, X.,Ansari, A.,Jadhav, P.,Tan, H.,Li, K.,Chopra, A.,Ford, A.,Chi, X.,Ruiz, F.X.,Arnold, E.,Deng, X.,Wang, J. Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model Science 2024 383 1434 1440