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Cation diffusion facilitators transport initiation and regulation is mediated by cation induced conformational changes of the cytoplasmic domain Plos One 2014 9 0 0 3W62 24658343 MamM-CTD E289A 2013-02-10 2014-04-16 Zeytuni, N.,Uebe, R.,Maes, M.,Davidov, G.,Baram, M.,Raschdorf, O.,Nadav-Tsubery, M.,Kolusheva, S.,Bitton, R.,Goobes, G.,Friedler, A.,Miller, Y.,Schuler, D.,Zarivach, R. Cation diffusion facilitators transport initiation and regulation is mediated by cation induced conformational changes of the cytoplasmic domain Plos One 2014 9 0 0 3W63 24658343 MamM-CTD 215-293 2013-02-10 2014-04-16 Zeytuni, N.,Uebe, R.,Maes, M.,Davidov, G.,Baram, M.,Raschdorf, O.,Nadav-Tsubery, M.,Kolusheva, S.,Bitton, R.,Goobes, G.,Friedler, A.,Miller, Y.,Schuler, D.,Zarivach, R. 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Proc.Natl.Acad.Sci.USA 2014 111 17516 0 4CHK 24710426 Crystal Structure of the ARF5 oligomerization domain 2013-12-03 2014-04-16 Nanao, M.H.,Vinos-Poyo, T.,Brunoud, G.,Thevenon, E.,Mazzoleni, M.,Mast, D.,Laine, S.,Wang, S.,Hagen, G.,Li, H.,Guilfoyle, T.J.,Parcy, F.,Vernoux, T.,Dumas, R. Structural Basis for Oligomerisation of Auxin Transcriptional Regulators Nat.Commun. 2014 5 3617 0 4CIV 24689821 Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-hydroxymethylcyclohex-2-ene-1-carboxylic acid 2013-12-17 2014-04-16 Blanco, B.,Sedes, A.,Peon, A.,Otero, J.M.,van Raaij, M.J.,Thompson, P.,Hawkins, A.R.,Gonzalez-Bello, C. Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors. J. Med. 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The Trp114 residue of thioredoxin reductase 1 is an electron relay sensor for oxidative stress To be Published 2013 0 0 0 4KPW 25798950 Crystal structure of His-tagged human thymidylate synthase R175A mutant 2013-05-14 2014-05-14 Salo-Ahen, O.M.,Tochowicz, A.,Pozzi, C.,Cardinale, D.,Ferrari, S.,Boum, Y.,Mangani, S.,Stroud, R.M.,Saxena, P.,Myllykallio, H.,Costi, M.P.,Ponterini, G.,Wade, R.C. Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J.Med.Chem. 2015 58 3572 3581 4CDM 24849603 Crystal structure of M. mazei photolyase soaked with synthetic 8-HDF 2013-11-01 2014-05-21 Kiontke, S.,Gnau, P.,Haselsberger, R.,Batschauer, A.,Essen, L. Structural and Evolutionary Aspects of Antenna Chromophore Usage by Class II Photolyases. J.Biol.Chem. 2014 289 19659 0 4CJ0 24823716 Crystal structure of CelD in complex with affitin E12 2013-12-18 2014-05-21 Correa, A.,Pacheco, S.,Mechaly, A.E.,Obal, G.,Behar, G.,Mouratou, B.,Oppezzo, P.,Alzari, P.M.,Pecorari, F. Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins) Plos One 2014 9 97438 0 4CJ1 24823716 Crystal structure of CelD in complex with affitin H3 2013-12-18 2014-05-21 Correa, A.,Pacheco, S.,Mechaly, A.E.,Obal, G.,Behar, G.,Mouratou, B.,Oppezzo, P.,Alzari, P.M.,Pecorari, F. 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Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors. Science 2014 344 1035 0 4COC 24843179 HIV-1 capsid C-terminal domain mutant (Y169L) 2014-01-28 2014-06-04 Bharat, T.A.M.,Castillo Menendez, L.R.,Hagen, W.J.H.,Lux, V.,Igonet, S.,Schorb, M.,Schur, F.K.M.,Krausslich, H.,Briggs, J.A.G. Cryo-Electron Microscopy of Tubular Arrays of HIV-1 Gag Resolves Structures Essential for Immature Virus Assembly. Proc.Natl.Acad.Sci.USA 2014 111 8233 0 4MEE 24841284 Crystal structure of the transport unit of the autotransporter AIDA-I from Escherichia coli 2013-08-26 2014-06-04 Gawarzewski, I.,DiMaio, F.,Winterer, E.,Tschapek, B.,Smits, S.H.,Jose, J.,Schmitt, L. Crystal structure of the transport unit of the autotransporter adhesin involved in diffuse adherence from Escherichia coli. J.Struct.Biol. 2014 187 20 29 4OJ3 24893801 The crystal structure of V84P mutant of S. solfataricus Acylphosphatase 2014-01-20 2014-06-04 de Rosa, M.,Bemporad, F.,Pellegrino, S.,Chiti, F.,Bolognesi, M.,Ricagno, S. Edge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphatase. Febs J. 2014 281 4072 4084 4ICU 25908846 Ubiquitin-like domain of human tubulin folding cofactor E - crystal from A 2012-12-11 2014-06-18 Serna, M.,Carranza, G.,Martin-Benito, J.,Janowski, R.,Canals, A.,Coll, M.,Zabala, J.C.,Valpuesta, J.M. The structure of the complex between alpha-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism. J.Cell.Sci. 2015 128 1824 1834 4ICV 25908846 Ubiquitin-like domain of human tubulin folding cofactor E - crystal form B 2012-12-11 2014-06-18 Serna, M.,Carranza, G.,Martin-Benito, J.,Janowski, R.,Canals, A.,Coll, M.,Zabala, J.C.,Valpuesta, J.M. 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Acta Crystallogr.,Sect.D 2014 70 1640 1648 4P2L 24888638 Quiescin Sulfhydryl Oxidase from Rattus norvegicus 2014-03-04 2014-06-25 Gat, Y.,Vardi-Kilshtain, A.,Grossman, I.,Major, D.T.,Fass, D. Enzyme structure captures four cysteines aligned for disulfide relay. Protein Sci. 2014 23 1102 1112 4TQG 25035429 Crystal structure of Megavirus UDP-GlcNAc 4,6-dehydratase, 5-epimerase Mg534 2014-06-11 2014-06-25 Piacente, F.,De Castro, C.,Jeudy, S.,Molinaro, A.,Salis, A.,Damonte, G.,Bernardi, C.,Abergel, C.,Tonetti, M.G. Giant Virus Megavirus chilensis Encodes the Biosynthetic Pathway for Uncommon Acetamido Sugars. J.Biol.Chem. 2014 289 24428 24439 4OKD 24993830 Crystal Structure of Chlamydomonas reinhardtii Isoamylase 1 (ISA1) in complex with maltoheptaose 2014-01-22 2014-07-02 Sim, L.,Beeren, S.R.,Findinier, J.,Dauvillee, D.,Ball, S.G.,Henriksen, A.,Palcic, M.M. 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Biochem.J. 2014 462 499 0 4BVV Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. 2013-06-28 2014-07-16 Sandmark, J.,Althage, M.,Andersson, G.M.K.,Antonsson, T.,Blaho, S.,Bodin, C.,Bostrom, J.,Chen, Y.,Dahlen, A.,Eriksson, P.O.,Evertsson, E.,Fex, T.,Fjellstrom, O.,Gustafsson, D.,Hallberg, C.,Hicks, R.,Jarkvist, E.,Johansson, C.,Kalies, I.,Kang, D.,Svalstedt Karlsson, B.,Kartberg, F.,Legnehed, A.,Lindqvist, A.M.,Martinsson, S.A.,Moberg, A.,Petersson, A.U.,Ridderstrom, M.,Thelin, A.,Tigerstrom, A.,Vinblad, J.,Xu, B.,Knecht, W. 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Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A) To be Published 0 0 0 0 4N1L 25004977 Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions 2013-10-04 2014-07-16 Eibl, C.,Hessenberger, M.,Wenger, J.,Brandstetter, H. Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. Acta Crystallogr.,Sect.D 2014 70 2007 2018 4QHF 25159620 Crystal structure of Methanocaldococcus jannaschii monomeric selecase 2014-05-28 2014-07-16 Lopez-Pelegrin, M.,Cerda-Costa, N.,Cintas-Pedrola, A.,Herranz-Trillo, F.,Bernado, P.,Peinado, J.R.,Arolas, J.L.,Gomis-Ruth, F.X. Multiple stable conformations account for reversible concentration-dependent oligomerization and autoinhibition of a metamorphic metallopeptidase Angew.Chem.Int.Ed.Engl. 2014 53 10624 10630 4QHH 25159620 Crystal structure of Methanocaldococcus jannaschii tetrameric selecase 2014-05-28 2014-07-16 Lopez-Pelegrin, M.,Cerda-Costa, N.,Cintas-Pedrola, A.,Herranz-Trillo, F.,Bernado, P.,Peinado, J.R.,Arolas, J.L.,Gomis-Ruth, F.X. Multiple stable conformations account for reversible concentration-dependent oligomerization and autoinhibition of a metamorphic metallopeptidase Angew.Chem.Int.Ed.Engl. 2014 53 10624 10630 4QHI 25159620 Crystal structure of Methanocaldococcus jannaschii selecase mutant R36W 2014-05-28 2014-07-16 Lopez-Pelegrin, M.,Cerda-Costa, N.,Cintas-Pedrola, A.,Herranz-Trillo, F.,Bernado, P.,Peinado, J.R.,Arolas, J.L.,Gomis-Ruth, F.X. 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Chemmedchem 2016 11 2024 2036 5JC1 27487410 Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC55 and manganese 2016-04-14 2016-08-24 Sooriyaarachchi, S.,Chofor, R.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Dowd, C.S.,Maes, L.,Wouters, J.,Jones, T.A.,Van Calenbergh, S.,Mowbray, S.L. Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin. Chemmedchem 2016 11 2024 2036 5JMP 27487410 Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC57 and manganese 2016-04-29 2016-08-24 Sooriyaarachchi, S.,Chofor, R.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Dowd, C.S.,Maes, L.,Wouters, J.,Jones, T.A.,Van Calenbergh, S.,Mowbray, S.L. Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin. Chemmedchem 2016 11 2024 2036 5LN8 27507539 Crystal structure of self-complemented MyfA, the major subunit of Myf fimbriae from Yersinia enterocolitica, in complex with galactose 2016-08-03 2016-08-24 Pakharukova, N.,Roy, S.,Tuittila, M.,Rahman, M.M.,Paavilainen, S.,Ingars, A.K.,Skaldin, M.,Lamminmaki, U.,Hard, T.,Teneberg, S.,Zavialov, A.V. Structural basis for Myf and Psa fimbriae-mediated tropism of pathogenic strains of Yersinia for host tissues. Mol.Microbiol. 2016 102 593 610 5F35 27545412 Structure of quinolinate synthase in complex with citrate 2015-12-02 2016-08-31 Volbeda, A.,Darnault, C.,Renoux, O.,Reichmann, D.,Amara, P.,Ollagnier de Choudens, S.,Fontecilla-Camps, J.C. Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product. J.Am.Chem.Soc. 2016 138 11802 11809 5HCB 27840680 Globular Domain of the Entamoeba histolytica calreticulin in complex with glucose 2016-01-04 2016-08-31 Moreau, C.,Cioci, G.,Iannello, M.,Laffly, E.,Chouquet, A.,Ferreira, A.,Thielens, N.M.,Gaboriaud, C. Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties. IUCrJ 2016 3 408 419 5DMD 27551070 Crystal structure of the flagellar assembly factor FliW 2015-09-08 2016-09-07 Altegoer, F.,Rensing, S.A.,Bange, G. Structural basis for the CsrA-dependent modulation of translation initiation by an ancient regulatory protein. Proc.Natl.Acad.Sci.USA 2016 113 10168 10173 5J03 27564677 Crystal Structure of a chimeric Kv7.2 - Kv7.3 proximal C-terminal Domain in Complex with Calmodulin 2016-03-26 2016-09-07 Strulovich, R.,Tobelaim, W.S.,Attali, B.,Hirsch, J.A. Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex. 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Angew.Chem.Int.Ed.Engl. 2016 55 14852 14857 5LJY 27783711 Structure of hantavirus envelope glycoprotein Gc in complex with scFv A5 2016-07-20 2016-09-14 Guardado-Calvo, P.,Bignon, E.A.,Stettner, E.,Jeffers, S.A.,Perez-Vargas, J.,Pehau-Arnaudet, G.,Tortorici, M.A.,Jestin, J.L.,England, P.,Tischler, N.D.,Rey, F.A. Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc. Plos Pathog. 2016 12 0 0 5HKK 27621435 Caldalaklibacillus thermarum F1-ATPase (wild type) 2016-01-14 2016-09-21 Ferguson, S.A.,Cook, G.M.,Montgomery, M.G.,Leslie, A.G.,Walker, J.E. Regulation of the thermoalkaliphilic F1-ATPase from Caldalkalibacillus thermarum. Proc.Natl.Acad.Sci.USA 2016 113 10860 10865 5IK2 27621435 Caldalaklibacillus thermarum F1-ATPase (epsilon mutant) 2016-03-03 2016-09-21 Ferguson, S.A.,Cook, G.M.,Montgomery, M.G.,Leslie, A.G.,Walker, J.E. 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Sci Rep 2016 6 37708 37708 5M11 27883039 Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. 2016-10-07 2016-11-09 Lasica, A.M.,Goulas, T.,Mizgalska, D.,Zhou, X.,de Diego, I.,Ksiazek, M.,Madej, M.,Guo, Y.,Guevara, T.,Nowak, M.,Potempa, B.,Goel, A.,Sztukowska, M.,Prabhakar, A.T.,Bzowska, M.,Widziolek, M.,Thgersen, I.B.,Enghild, J.J.,Simonian, M.,Kulczyk, A.W.,Nguyen, K.A.,Potempa, J.,Gomis-Ruth, F.X. Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. Sci Rep 2016 6 37708 37708 5M11 27883039 Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. 2016-10-07 2016-11-09 Lasica, A.M.,Goulas, T.,Mizgalska, D.,Zhou, X.,de Diego, I.,Ksiazek, M.,Madej, M.,Guo, Y.,Guevara, T.,Nowak, M.,Potempa, B.,Goel, A.,Sztukowska, M.,Prabhakar, A.T.,Bzowska, M.,Widziolek, M.,Thgersen, I.B.,Enghild, J.J.,Simonian, M.,Kulczyk, A.W.,Nguyen, K.A.,Potempa, J.,Gomis-Ruth, F.X. Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. Sci Rep 2016 6 37708 37708 5KOD 27849615 Crystal Structure of GH3.5 Acyl Acid Amido Synthetase from Arabidopsis thaliana 2016-06-30 2016-11-16 Westfall, C.S.,Sherp, A.M.,Zubieta, C.,Alvarez, S.,Schraft, E.,Marcellin, R.,Ramirez, L.,Jez, J.M. 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Sci Rep 2016 6 35429 35429 5LS9 27942679 Humanized Archaeal ferritin 2016-08-23 2016-11-30 de Turris, V.,Cardoso Trabuco, M.,Peruzzi, G.,Boffi, A.,Testi, C.,Vallone, B.,Celeste Montemiglio, L.,Georges, A.D.,Calisti, L.,Benni, I.,Bonamore, A.,Baiocco, P. Humanized archaeal ferritin as a tool for cell targeted delivery. Nanoscale 2017 9 647 655 5M3Q 27863450 Crystal structure of Tif6 from Chaetomium thermophilum 2016-10-17 2016-11-30 Baler, J.,Ahmed, Y.L.,Kallas, M.,Kornprobst, M.,Calvino, F.R.,Gnadig, M.,Thoms, M.,Stier, G.,Ismail, S.,Kharde, S.,Castillo, N.,Griesel, S.,Bastuck, S.,Bradatsch, B.,Thomson, E.,Flemming, D.,Sinning, I.,Hurt, E. Interaction network of the ribosome assembly machinery from a eukaryotic thermophile. 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Biochemistry 2017 56 4689 4700 5NIH 28691798 Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution. 2017-03-24 2017-07-26 Mllerud, S.,Pinto, A.,Marconi, L.,Frydenvang, K.,Thorsen, T.S.,Laulumaa, S.,Venskutonyte, R.,Winther, S.,Moral, A.M.C.,Tamborini, L.,Conti, P.,Pickering, D.S.,Kastrup, J.S. Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci 2017 8 2056 2064 5NQS 28698367 Structure of the Arabidopsis Thaliana TOPLESS N-terminal domain 2017-04-21 2017-07-26 Martin-Arevalillo, R.,Nanao, M.H.,Larrieu, A.,Vinos-Poyo, T.,Mast, D.,Galvan-Ampudia, C.,Brunoud, G.,Vernoux, T.,Dumas, R.,Parcy, F. Structure of the Arabidopsis TOPLESS corepressor provides insight into the evolution of transcriptional repression. Proc. Natl. Acad. Sci. 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Acta 2017 1865 1227 1236 5O1W 28973465 Structure of Nrd1 RNA binding domain 2017-05-19 2017-08-02 Franco-Echevarria, E.,Gonzalez-Polo, N.,Zorrilla, S.,Martinez-Lumbreras, S.,Santiveri, C.M.,Campos-Olivas, R.,Sanchez, M.,Calvo, O.,Gonzalez, B.,Perez-Canadillas, J.M. The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition. Nucleic Acids Res. 2017 45 10293 10305 5LOR human NUDT22 2016-08-09 2017-08-16 Carter, M.,Ann-Sofie, J.,Patrick, H.,Puigvert, J.C.,Carranza, M.M.,Vallin, K.S.A.,Helleday, T.,Stenmark, P. Structural and functional studies of human NUDT22 To Be Published 0 0 0 0 5N69 28775348 Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil 2017-02-14 2017-08-16 Planelles-Herrero, V.J.,Hartman, J.J.,Robert-Paganin, J.,Malik, F.I.,Houdusse, A. Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun 2017 8 190 190 5LP5 28974686 Complex between Penicillin-Binding Protein (PBP2) and MreC from Helicobacter pylori 2016-08-11 2017-08-23 Contreras-Martel, C.,Martins, A.,Ecobichon, C.,Trindade, D.M.,Mattei, P.J.,Hicham, S.,Hardouin, P.,Ghachi, M.E.,Boneca, I.G.,Dessen, A. Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex. Nat Commun 2017 8 776 776 5NIE 28827365 Crystal structure of human LTA4H mutant R563A in open conformation 2017-03-23 2017-08-23 Stsiapanava, A.,Samuelsson, B.,Haeggstrom, J.Z. Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis. Proc. Natl. Acad. Sci. U.S.A. 2017 114 9689 9694 5OKN 28792888 Crystal structure of human SHIP2 Phosphatase-C2 D607A mutant 2017-07-25 2017-08-23 Le Coq, J.,Camacho-Artacho, M.,Velazquez, J.V.,Santiveri, C.M.,Gallego, L.H.,Campos-Olivas, R.,Dolker, N.,Lietha, D. 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ACS Infect Dis 2017 3 666 675 5O5O 28977623 X-ray crystal structure of RapZ from Escherichia coli (P32 space group) 2017-06-02 2017-08-30 Gonzalez, G.M.,Durica-Mitic, S.,Hardwick, S.W.,Moncrieffe, M.C.,Resch, M.,Neumann, P.,Ficner, R.,Gorke, B.,Luisi, B.F. Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism. Nucleic Acids Res. 2017 45 10845 10860 5O9E 28813493 Crystal structure of the Imp4-Mpp10 complex from Chaetomium thermophilum 2017-06-19 2017-08-30 Sa-Moura, B.,Kornprobst, M.,Kharde, S.,Ahmed, Y.L.,Stier, G.,Kunze, R.,Sinning, I.,Hurt, E. Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome. PLoS ONE 2017 12 0 0 5OA5 28860192 CELLOBIOHYDROLASE I (CEL7A) FROM HYPOCREA JECORINA WITH IMPROVED THERMAL STABILITY 2017-06-20 2017-09-06 Goedegebuur, F.,Dankmeyer, L.,Gualfetti, P.,Karkehabadi, S.,Hansson, H.,Jana, S.,Huynh, V.,Kelemen, B.R.,Kruithof, P.,Larenas, E.A.,Teunissen, P.J.M.,Stahlberg, J.,Payne, C.M.,Mitchinson, C.,Sandgren, M. Improving the thermal stability of cellobiohydrolase Cel7A from Hypocrea jecorina by directed evolution. J. Biol. Chem. 2017 292 17418 17430 5T2T 29765612 Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001 2016-08-24 2017-09-13 Saez-Ayala, M.,Yekwa, E.L.,Carcelli, M.,Canard, B.,Alvarez, K.,Ferron, F. Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. 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Science 2017 358 377 381 5LFC Crystal structure of Leuconostoc citreum NRRL B-1299 N-terminally truncated dextransucrase DSR-M 2016-07-01 2017-10-11 Claverie, M.,Cioci, G.,Vuillemin, M.,Monties, N.,Roblin, P.,Lippens, G.,Remaud-simeon, M.,Moulis, C. Investigations on the Determinants Responsible for Low Molar Mass Dextran Formation by DSR-M Dextransucrase Acs Catalysis 2017 7 7106 7119 5OBZ 28977422 low resolution structure of the p34ct/p44ct minimal complex 2017-06-29 2017-10-18 Radu, L.,Schoenwetter, E.,Braun, C.,Marcoux, J.,Koelmel, W.,Schmitt, D.R.,Kuper, J.,Cianferani, S.,Egly, J.M.,Poterszman, A.,Kisker, C. The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH. 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Angew.Chem.Int.Ed.Engl. 2021 60 813 819 6SHW 33239452 N-terminal domain of Drosophila X Virus VP3 2019-08-08 2020-11-18 Ferrero, D.S.,Busnadiego, I.,Garriga, D.,Guerra, P.,Martin, M.T.,Kremer, L.,Uson, I.,Rodriguez, J.F.,Verdaguer, N. Structure and dsRNA-binding activity of the Birnavirus Drosophila X Virus VP3 protein. J.Virol. 2020 0 0 0 6TAO 34799450 The cytotoxin MakE from Vibrio cholerae 2019-10-30 2020-11-18 Nadeem, A.,Nagampalli, R.,Toh, E.,Alam, A.,Myint, S.L.,Heidler, T.V.,Dongre, M.,Zlatkov, N.,Pace, H.,Bano, F.,Sjostedt, A.,Bally, M.,Uhlin, B.E.,Wai, S.N.,Persson, K. A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion. Proc.Natl.Acad.Sci.USA 2021 118 0 0 6TIX Crystal structure of penicillin-binding protein 2 from Yersinia pestis in complex with mecillinam 2019-11-22 2020-12-02 Pankov, G. The structure of penicillin-binding protein 2 from Yersinia pestis in complex with mecillinam To Be Published 0 0 0 0 7A1B 33317841 Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6-dibromo-1H-triazolo[4,5-b]pyridine 2020-08-12 2020-12-09 Chojnacki, K.,Lindenblatt, D.,Winska, P.,Wielechowska, M.,Toelzer, C.,Niefind, K.,Bretner, M. Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem. 2021 106 104502 104502 7A1Z 33317841 Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 6-bromo-5-chloro-1H-triazolo[4,5-b]pyridine 2020-08-14 2020-12-09 Chojnacki, K.,Lindenblatt, D.,Winska, P.,Wielechowska, M.,Toelzer, C.,Niefind, K.,Bretner, M. Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem. 2021 106 104502 104502 7A22 33317841 Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine 2020-08-15 2020-12-09 Chojnacki, K.,Lindenblatt, D.,Winska, P.,Wielechowska, M.,Toelzer, C.,Niefind, K.,Bretner, M. Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem. 2021 106 104502 104502 7A2H 33317841 Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-imidazo[4,5-b]pyridine 2020-08-18 2020-12-09 Chojnacki, K.,Lindenblatt, D.,Winska, P.,Wielechowska, M.,Toelzer, C.,Niefind, K.,Bretner, M. Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem. 2021 106 104502 104502 7AGQ 33237724 Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis 2020-09-23 2020-12-16 Grabowska, A.D.,Brison, Y.,Maveyraud, L.,Gavalda, S.,Faille, A.,Nahoum, V.,Bon, C.,Guilhot, C.,Pedelacq, J.D.,Chalut, C.,Mourey, L. Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol. 2020 15 3206 3216 6YW0 33319810 Lysine-N,N-Dimethylated HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with BB-287 2020-04-29 2020-12-30 Chowdhury, R.,Abboud, M.I.,McAllister, T.E.,Banerji, B.,Bhushan, B.,Sorensen, J.L.,Kawamura, A.,Schofield, C.J. Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep 2020 10 21964 21964 7AX8 33361153 Crystal structure of the hPXR-LBD in apo form (P43212 SG) 2020-11-09 2021-01-13 Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7AXF 33361153 Crystal structure of the hPXR-LBD in complex with pretilachlor 2020-11-09 2021-01-13 Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7AXG 33361153 Crystal structure of the hPXR-LBD in complex with tributyltin 2020-11-09 2021-01-13 Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7AXH 33361153 Crystal structure of the hPXR-LBD in complex with alpha-zearalanol 2020-11-09 2021-01-13 Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7AXI 33361153 Crystal structure of the hPXR-LBD in complex with estradiol and cis-chlordane 2020-11-09 2021-01-13 Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7AXK 33361153 Crystal structure of the hPXR-LBD in complex with estradiol and endosulfan 2020-11-09 2021-01-13 Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W. Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA 2021 118 0 0 6SSS 33741927 Crystal structure of Human Microsomal Glutathione S-Transferase 2 2019-09-09 2021-02-03 Thulasingam, M.,Orellana, L.,Nji, E.,Ahmad, S.,Rinaldo-Matthis, A.,Haeggstrom, J.Z. Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. Nat Commun 2021 12 1728 1728 6SSW 33741927 Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with an Inhibitor Glutathione sulfonic acid 2019-09-09 2021-02-03 Thulasingam, M.,Orellana, L.,Nji, E.,Ahmad, S.,Rinaldo-Matthis, A.,Haeggstrom, J.Z. Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. Nat Commun 2021 12 1728 1728 6XUL 34119488 Apo Ab 5b1 2020-01-20 2021-02-03 Borenstein-Katz, A.,Warszawski, S.,Amon, R.,Eilon, M.,Cohen-Dvashi, H.,Leviatan Ben-Arye, S.,Tasnima, N.,Yu, H.,Chen, X.,Padler-Karavani, V.,Fleishman, S.J.,Diskin, R. Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies. J.Mol.Biol. 2021 433 167099 167099 6XUN 34119488 Ab 5b1 bound to CA19-9 2020-01-20 2021-02-03 Borenstein-Katz, A.,Warszawski, S.,Amon, R.,Eilon, M.,Cohen-Dvashi, H.,Leviatan Ben-Arye, S.,Tasnima, N.,Yu, H.,Chen, X.,Padler-Karavani, V.,Fleishman, S.J.,Diskin, R. Biomolecular Recognition of the Glycan Neoantigen CA19-9 by Distinct Antibodies. J.Mol.Biol. 2021 433 167099 167099 6VPZ HLA-B*27:05 presenting an HIV-1 11mer peptide 2020-02-04 2021-02-10 Pymm, P.,Tenzer, S.,Wee, E.,Weimershaus, M.,Burgevin, A.,Kollnberger, S.,Gerstoft, J.,Josephs, T.M.,Ladell, K.,McLaren, J.E.,Appay, V.,Price, D.A.,Fugger, L.,Bell, J.I.,Schild, H.,van Endert, P.,Harkiolaki, M.,Iversen, A.K. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection Cell Rep 2022 38 0 0 6ZT0 33824334 Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex 2020-07-17 2021-03-03 Palmerini, V.,Monzani, S.,Laurichesse, Q.,Loudhaief, R.,Mari, S.,Cecatiello, V.,Olieric, V.,Pasqualato, S.,Colombani, J.,Andersen, D.S.,Mapelli, M. Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions. Nat Commun 2021 12 2070 2070 7A6P 33621443 Structural determinants underlying the adduct lifetime in a short LOV protein PpSB2-LOV 2020-08-26 2021-03-10 Arinkin, V.,Granzin, J.,Krauss, U.,Jaeger, K.E.,Willbold, D.,Batra-Safferling, R. Structural determinants underlying the adduct lifetime in the LOV proteins of Pseudomonas putida. Febs J. 2021 288 4955 4972 7BJ6 33761253 Inhibitor of MDM2-p53 Interaction 2021-01-14 2021-04-07 Chessari, G.,Hardcastle, I.R.,Ahn, J.S.,Anil, B.,Anscombe, E.,Bawn, R.H.,Bevan, L.D.,Blackburn, T.J.,Buck, I.,Cano, C.,Carbain, B.,Castro, J.,Cons, B.,Cully, S.J.,Endicott, J.A.,Fazal, L.,Golding, B.T.,Griffin, R.J.,Haggerty, K.,Harnor, S.J.,Hearn, K.,Hobson, S.,Holvey, R.S.,Howard, S.,Jennings, C.E.,Johnson, C.N.,Lunec, J.,Miller, D.C.,Newell, D.R.,Noble, M.E.M.,Reeks, J.,Revill, C.H.,Riedinger, C.,St Denis, J.D.,Tamanini, E.,Thomas, H.,Thompson, N.T.,Vinkovic, M.,Wedge, S.R.,Williams, P.A.,Wilsher, N.E.,Zhang, B.,Zhao, Y. Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem. 2021 64 4071 4088 7NDY 33744941 Di-phosphorylated Barrier-to-Autointegration Factor (BAF) in complex with LEM domain of Emerin 2021-02-02 2021-04-07 Marcelot, A.,Petitalot, A.,Ropars, V.,Le Du, M.H.,Samson, C.,Dubois, S.,Hoffmann, G.,Miron, S.,Cuniasse, P.,Marquez, J.A.,Thai, R.,Theillet, F.X.,Zinn-Justin, S. Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners. Nucleic Acids Res. 2021 49 3841 3855 6YJG 34529927 Crystal structure of MINDY1 mutant-Y114F 2020-04-03 2021-04-14 Abdul Rehman, S.A.,Armstrong, L.A.,Lange, S.M.,Kristariyanto, Y.A.,Grawert, T.W.,Knebel, A.,Svergun, D.I.,Kulathu, Y. Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol.Cell 2021 81 4176 0 6Z0P 34439861 BceF Tyrosine Kinase Domain 2020-05-10 2021-04-14 Mayer, M.,Matiuhin, Y.,Nawatha, M.,Tabachnikov, O.,Fish, I.,Schutz, N.,Dvir, H.,Landau, M. Structural and Functional Insights into the Biofilm-Associated BceF Tyrosine Kinase Domain from Burkholderia cepacia . Biomolecules 2021 11 0 0 6ZIE 33771865 Crystal structure of MCL-1 in complex with a neutralizing Alphabody CMPX-383B 2020-06-25 2021-04-28 Pannecoucke, E.,Van Trimpont, M.,Desmet, J.,Pieters, T.,Reunes, L.,Demoen, L.,Vuylsteke, M.,Loverix, S.,Vandenbroucke, K.,Alard, P.,Henderikx, P.,Deroo, S.,Baatz, F.,Lorent, E.,Thiolloy, S.,Somers, K.,McGrath, Y.,Van Vlierberghe, P.,Lasters, I.,Savvides, S.N. Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting. Sci Adv 2021 7 0 0 6TEC Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Xylose 2019-11-11 2021-05-19 Mattoteia, D.,Chiapparino, A.,Fumagalli, M.,De Marco, M.,De Giorgi, F.,Negro, L.,Pinnola, A.,Faravelli, S.,Roscioli, T.,Scietti, L.,Forneris, F. Identification of Regulatory Molecular 'Hot Spots' for LH/PLOD Collagen Glycosyltransferase Activity Int J Mol Sci 2023 0 0 0 6ZXO 33923290 Crystal structure of His-tagged human thymidylate synthase (HT-hTS) in complex with FdUMP and Raltitrexed (Tomudex) 2020-07-30 2021-05-19 Pozzi, C.,Santucci, M.,Marverti, G.,D'Arca, D.,Tagliazucchi, L.,Ferrari, S.,Gozzi, G.,Losi, L.,Tassone, G.,Mangani, S.,Ponterini, G.,Costi, M.P. Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations. Cancers (Basel) 2021 13 0 0 6TET 34010508 The structure of CYP121 in complex with inhibitor L21 2019-11-12 2021-05-26 Walter, I.,Adam, S.,Gentilini, M.V.,Kany, A.M.,Brengel, C.,Thomann, A.,Sparwasser, T.,Kohnke, J.,Hartmann, R.W. Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors. Chemmedchem 2021 16 2786 2801 6Z13 35665969 VEGF-A 13:107 crystallized with 3C bicyclic peptide 2020-05-12 2021-05-26 Gaucher, J.F.,Reille-Seroussi, M.,Broussy, S. Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands. Chemistry 2022 0 0 0 6TGW 34934174 Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor 2019-11-18 2021-06-02 Li, J.,Garavaglia, S.,Ye, Z.,Moretti, A.,Belyaeva, O.V.,Beiser, A.,Ibrahim, M.,Wilk, A.,McClellan, S.,Klyuyeva, A.V.,Goggans, K.R.,Kedishvili, N.Y.,Salter, E.A.,Wierzbicki, A.,Migaud, M.E.,Mullett, S.J.,Yates, N.A.,Camacho, C.J.,Rizzi, M.,Sobol, R.W. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Commun Biol 2021 4 1420 1420 7A1R 33997700 Crystal structure of the C2B domain of Trypanosoma brucei extended synaptotagmin (E-Syt) 2020-08-13 2021-06-02 Stepinac, E.,Landrein, N.,Skwarzynska, D.,Wojcik, P.,Lesigang, J.,Lucic, I.,He, C.Y.,Bonhivers, M.,Robinson, D.R.,Dong, G. Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei . Iscience 2021 24 102422 102422 6XVU 34285211 Bacteriophytochrome response regulator from Deinococcus radiodurans 2020-01-22 2021-06-30 Multamaki, E.,Nanekar, R.,Morozov, D.,Lievonen, T.,Golonka, D.,Wahlgren, W.Y.,Stucki-Buchli, B.,Rossi, J.,Hytonen, V.P.,Westenhoff, S.,Ihalainen, J.A.,Moglich, A.,Takala, H. Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling. Nat Commun 2021 12 4394 4394 7BK5 33896006 PfCopC mutant - E27A 2021-01-15 2021-07-07 Ipsen, J.O.,Hernandez-Rollan, C.,Muderspach, S.J.,Brander, S.,Bertelsen, A.B.,Jensen, P.E.,Norholm, M.H.H.,Lo Leggio, L.,Johansen, K.S. Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC. Febs Lett. 2021 595 1708 1720 7BK7 33896006 PfCopC mutant - D83N 2021-01-15 2021-07-07 Ipsen, J.O.,Hernandez-Rollan, C.,Muderspach, S.J.,Brander, S.,Bertelsen, A.B.,Jensen, P.E.,Norholm, M.H.H.,Lo Leggio, L.,Johansen, K.S. Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC. Febs Lett. 2021 595 1708 1720 6ZRJ Crystal structure of class D Beta-lactamase OXA-48 in complex with ertapenem 2020-07-13 2021-07-21 Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Docquier, J.D.,Mangani, S. Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48 To Be Published 0 0 0 0 6ZRP Crystal structure of class D Beta-lactamase OXA-48 in complex with meropenem 2020-07-14 2021-07-21 Tassone, G.,De Luca, F.,Pozzi, C.,Di Pisa, F.,Benvenuti, M.,Mangani, S.,Doquier, J.D. Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48 To Be Published 0 0 0 0 6ZVA Crystal structure of My5 2020-07-24 2021-08-04 Sauer, F.,Wilmanns, M. Crystal structure of Myomesin-1 To Be Published 0 0 0 0 7AT9 34323071 Structure of protein kinase ck2 catalytic subunit (csnk2a2 gene product) in complex with the ATP-competitive inhibitor MB002 and the alphaD-pocket ligand 3,4-dichlorophenethylamine 2020-10-29 2021-08-04 Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Gotz, C.,Jose, J.,Niefind, K. 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Structural and functional characterization of the bacterial biofilm activator RemA. Nat Commun 2021 12 5707 5707 7O6L 34413138 Crystal structure of C. elegans ERH-2 2021-04-11 2021-08-25 Perez-Borrajero, C.,Podvalnaya, N.,Holleis, K.,Lichtenberger, R.,Karaulanov, E.,Simon, B.,Basquin, J.,Hennig, J.,Ketting, R.F.,Falk, S. Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans . Genes Dev. 2021 35 1304 1323 7A56 36827185 Schmallenberg Virus Envelope Glycoprotein Gc Fusion Domains in Postfusion Conformation 2020-08-20 2021-09-01 Hellert, J.,Aebischer, A.,Haouz, A.,Guardado-Calvo, P.,Reiche, S.,Beer, M.,Rey, F.A. Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein. Cell Rep 2023 42 112142 112142 7O50 34621593 Crystal structure of human legumain in complex with Gly-Ser-Asn peptide 2021-04-07 2021-09-22 Dall, E.,Stanojlovic, V.,Demir, F.,Briza, P.,Dahms, S.O.,Huesgen, P.F.,Cabrele, C.,Brandstetter, H. 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Cell 2022 185 4206 0 7QZR 36150500 Structure of native leukocyte myeloperoxidase in complex with the Staphyloccal Peroxidase Inhibitor SPIN from Staphylococcus aureus 2022-01-31 2022-10-26 Leitgeb, U.,Furtmuller, P.G.,Hofbauer, S.,Brito, J.A.,Obinger, C.,Pfanzagl, V. The staphylococcal inhibitory protein SPIN binds to human myeloperoxidase with picomolar affinity but only dampens halide oxidation. J.Biol.Chem. 2022 298 102514 102514 7Z53 36150500 Structure of native leukocyte myeloperoxidase in complex with a truncated version (SPIN truncated) of the Staphyloccal Peroxidase Inhibitor SPIN from Staphylococcus aureus 2022-03-07 2022-10-26 Leitgeb, U.,Furtmuller, P.G.,Hofbauer, S.,Brito, J.A.,Obinger, C.,Pfanzagl, V. The staphylococcal inhibitory protein SPIN binds to human myeloperoxidase with picomolar affinity but only dampens halide oxidation. J.Biol.Chem. 2022 298 102514 102514 7Z5Y 36350642 CRYSTAL STRUCTURE OF WEISSELLA VIRIDESCENS FEMXVV NON-RIBOSOMAL AMINO ACID TRANSFERASE IN COMPLEX WITH A PEPTIDYL-XNA CONJUGATE 2022-03-10 2022-10-26 Rietmeyer, L.,Li De La Sierra-Gallay, I.,Schepers, G.,Dorchene, D.,Iannazzo, L.,Patin, D.,Touze, T.,van Tilbeurgh, H.,Herdewijn, P.,Etheve-Quelquejeu, M.,Fonvielle, M. Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis. Nucleic Acids Res. 2022 50 11415 11425 7ZTQ 36395947 Crystal structure of the carotenoid-binding protein domain from silkworm Bombyx mori (BmCBP) in the apoform 2022-05-11 2022-10-26 Sluchanko, N.N.,Slonimskiy, Y.B.,Egorkin, N.A.,Varfolomeeva, L.A.,Faletrov, Y.V.,Moysenovich, A.M.,Parshina, E.Y.,Friedrich, T.,Maksimov, E.G.,Boyko, K.M.,Popov, V.O. Silkworm carotenoprotein as an efficient carotenoid extractor, solubilizer and transporter. Int.J.Biol.Macromol. 2022 223 1381 1393 8AJY 36252630 Ruminococcus flavefaciens Cohesin-Dockerin structure: dockerin from ScaH adaptor scaffoldin in complex with the cohesin from ScaE anchoring scaffoldin 2022-07-28 2022-11-02 Duarte, M.,Alves, V.D.,Correia, M.,Caseiro, C.,Ferreira, L.M.A.,Romao, M.J.,Carvalho, A.L.,Najmudin, S.,Bayer, E.A.,Fontes, C.M.G.A.,Bule, P. Structure-function studies can improve binding affinity of cohesin-dockerin interactions for multi-protein assemblies. Int.J.Biol.Macromol. 2023 224 55 67 7QHZ 36320846 Crystal structure of KLK6 in complex with compound DKFZ917 2021-12-14 2022-11-23 Baumann, A.,Isak, D.,Lohbeck, J.,Jagtap, P.K.A.,Hennig, J.,Miller, A.K. Scalable synthesis and structural characterization of reversible KLK6 inhibitors. Rsc Adv 2022 12 26989 26993 7QP4 Complex of a Gemini-cholesterol analogue with Retinoid-related Orphan Receptor gamma 2022-01-02 2022-12-14 Gomez-Bouzo, U.,Fall, A.,Osz, J.,Fall, Y.,Rochel, N.,Santalla, H. Development of novel Gemini-cholesterol analogues for retinoid-related orphan receptors Org Chem Front 2022 9 1522 1530 7QFI Crystal structure of S-layer protein SlpX from Lactobacillus acidophilus, domain I (aa 31-182) 2021-12-06 2022-12-21 Sagmeister, T.,Eder, M.,Grininger, C.,Vejzovic, D.,Buhlheller, C.,Damisch, E.,Millan, C.,Medina, A.,Uson, I.,Baek, M.,Read, R.,Baker, D.,Pavkov-Keller, T. The self-assembly of the S-layer protein from Lactobacilli acidophilus To be published 0 0 0 0 7QIB Crystal structure of Mycobacterium hassiacum glucosyl-3-phosphoglycerate synthase at pH 8.5 in complex with UDP 2021-12-14 2022-12-28 Silva, A.,Nunes-Costa, D.,Barbosa Pereira, P.J.,Macedo-Ribeiro, S. Crystal structure of Mycobacterium hassiacum glucosyl-3-phosphoglycerate synthase at pH 8.5 in complex with UDP To Be Published 0 0 0 0 7QVQ 36430540 Human telomeric DNA G-quadruplex of a gold(III) complex containing the 2,4,6-tris (2-pyrimidyl)-1,3,5-triazine ligand 2022-01-23 2022-12-28 Bazzicalupi, C.,Bonardi, A.,Biver, T.,Ferraroni, M.,Papi, F.,Savastano, M.,Lombardi, P.,Gratteri, P. Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis. Int J Mol Sci 2022 23 0 0 7ZZC 36455355 Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a linear di-adenosine derivative 2022-05-25 2023-01-11 Clement, D.A.,Gelin, M.,Leseigneur, C.,Huteau, V.,Mondange, L.,Pons, J.L.,Dussurget, O.,Lionne, C.,Labesse, G.,Pochet, S. Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria. Eur.J.Med.Chem. 2023 246 114941 114941 7ZZF 36455355 Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a linear di-adenosine derivative 2022-05-25 2023-01-11 Clement, D.A.,Gelin, M.,Leseigneur, C.,Huteau, V.,Mondange, L.,Pons, J.L.,Dussurget, O.,Lionne, C.,Labesse, G.,Pochet, S. Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria. Eur.J.Med.Chem. 2023 246 114941 114941 7ZZG 36455355 Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a linear di-adenosine derivative 2022-05-25 2023-01-11 Clement, D.A.,Gelin, M.,Leseigneur, C.,Huteau, V.,Mondange, L.,Pons, J.L.,Dussurget, O.,Lionne, C.,Labesse, G.,Pochet, S. Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria. Eur.J.Med.Chem. 2023 246 114941 114941 7QOQ Crystal structure of Mycobacterium hassiacum glucosyl-3-phosphoglycerate synthase at pH 8.5 in complex with UMP and Magnesium 2021-12-27 2023-01-18 Silva, A.,Nunes-Costa, D.,Empadinhas, N.,Barbosa Pereira, P.J.,Macedo-Ribeiro, S. Crystal structure of Mycobacterium hassiacum glucosyl-3-phosphoglycerate synthase at pH 8.5 in complex with UMP and Magnesium To Be Published 0 0 0 0 7R2P Crystal structure of a flavodiiron protein D52K/S262Y mutant in the oxidized state from Escherichia coli 2022-02-05 2023-02-15 Borges, P.T.,Teixeira, M.,Romao, C.V.,Frazao, C. Crystal structure of a flavodiiron protein D52K/S262Y mutant in the oxidized state from Escherichia coli To Be Published 0 0 0 0 7R2R Crystal structure of a flavodiiron protein D52K/S262Y mutant in the reduced state from Escherichia coli 2022-02-05 2023-02-15 Borges, P.T.,Teixeira, M.,Romao, C.V.,Frazao, C. Crystal structure of a flavodiiron protein D52K/S262Y mutant in the reduced state from Escherichia coli To Be Published 0 0 0 0 8A67 Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with matured synthetic nanobody NbSL3.3Q (3rd generation) 2022-06-16 2023-02-15 Lange, S.M.,McFarland, M.R.,Lamoliatte, F.,Kwasna, D.,Shen, L.,Wallace, I.,Cole, I.,Armstrong, L.A.,Knebel, A.,Johnson, C.,De Cesare, V.,Kulathu, Y. Comprehensive approach to study branched ubiquitin chains reveals roles for K48-K63 branches in VCP/p97-related processes Biorxiv 2023 0 0 0 8B8F 36754262 Atomic structure of the beta-trefoil domain of the Laccaria bicolor lectin LBL in complex with lactose 2022-10-04 2023-02-22 Acebron, I.,Campanero-Rhodes, M.A.,Solis, D.,Menendez, M.,Garcia, C.,Lillo, M.P.,Mancheno, J.M. Atomic crystal structure and sugar specificity of a beta-trefoil lectin domain from the ectomycorrhizal basidiomycete Laccaria bicolor. Int.J.Biol.Macromol. 2023 233 123507 123507 8I8I 38456905 Crystal structure of Phosphopantetheine adenylyltransferase from Klebsiella pneumoniae at 2.59 A resolution 2023-02-04 2023-02-22 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Structure of a novel form of phosphopantetheine adenylyltransferase from Klebsiella pneumoniae at 2.59 angstrom resolution. Eur.Biophys.J. 2024 53 147 157 8I8J Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.07 A resolution. 2023-02-04 2023-03-01 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.07 A resolution. To Be Published 0 0 0 0 8I8K Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.13 A resolution. 2023-02-04 2023-03-01 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.13 A resolution. To Be Published 0 0 0 0 8I8L Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.23 A resolution. 2023-02-04 2023-03-01 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.23 A resolution. To Be Published 0 0 0 0 8AEP 37180375 Reductase domain of the carboxylate reductase of Neurospora crassa 2022-07-13 2023-03-08 Daniel, B.,Hashem, C.,Leithold, M.,Sagmeister, T.,Tripp, A.,Stolterfoht-Stock, H.,Messenlehner, J.,Keegan, R.,Winkler, C.K.,Ling, J.G.,Younes, S.H.H.,Oberdorfer, G.,Abu Bakar, F.D.,Gruber, K.,Pavkov-Keller, T.,Winkler, M. Structure of the Reductase Domain of a Fungal Carboxylic Acid Reductase and Its Substrate Scope in Thioester and Aldehyde Reduction. Acs Catalysis 2022 12 15668 15674 8AH8 Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P3121 at pH 3.7 2022-07-20 2023-03-08 Salinas-Garcia, M.C.,Plaza-Garrido, M.,Gavira, J.A.,Murciano-Calles, J.,Andujar-Sanchez, M.,Ortiz-Salmeron, E.,Martinez, J.C.,Camara-Artigas, A. pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals 2023 0 0 0 7PLJ Structure of Polyphosphate kinase 2 from Deinococcus radiodurans, in complex with ATP and polyphosphates. 2021-08-31 2023-03-22 Silva, S.T.N.,Romao, C.V. Structure of Polyphosphate kinase 2 from Deinococcus radiodurans, in complex with ATP and polyphosphates. To Be Published 0 0 0 0 7ZVH 36460243 Penicillium expansum antifungal protein B 2022-05-16 2023-03-22 Giner-Llorca, M.,Del Sol, F.G.,Marcos, J.F.,Marina, A.,Manzanares, P. Rationally designed antifungal protein chimeras reveal new insights into structure-activity relationship. Int.J.Biol.Macromol. 2023 225 135 148 7ZW2 36460243 Penicillium expansum antifungal protein B 2022-05-18 2023-03-22 Giner-Llorca, M.,Del Sol, F.G.,Marcos, J.F.,Marina, A.,Manzanares, P. Rationally designed antifungal protein chimeras reveal new insights into structure-activity relationship. Int.J.Biol.Macromol. 2023 225 135 148 7ZZL 36151590 Crystal structure of CYP106A1 2022-05-25 2023-04-12 Carius, Y.,Hutter, M.,Kiss, F.,Bernhardt, R.,Lancaster, C.R.D. Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion. Febs Lett. 2022 596 3133 3144 8I8M Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.65 A resolution. 2023-02-04 2023-04-12 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Coenzyme-A and Phosphonoacetic acid at 2.65 A resolution. To Be Published 0 0 0 0 8AGR 37042660 Crystal structure of DltE from L. plantarum, apo form 2022-07-20 2023-04-26 Nikolopoulos, N.,Matos, R.,Ravaud, S.,Courtin, P.,Akherraz, H.,Palussiere, S.,Gueguen-Chaignon, V.,Salomon-Mallet, M.,Guillot, A.,Guerardel, Y.,Chapot-Chartier, M.P.,Grangeasse, C.,Leulier, F. Structure-function analysis of Lactiplantibacillus plantarum DltE& reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth. Elife 2023 12 0 0 8AJI 37042660 Crystal structure of DltE from L. plantarum, TCEP form 2022-07-28 2023-04-26 Nikolopoulos, N.,Matos, R.,Ravaud, S.,Courtin, P.,Akherraz, H.,Palussiere, S.,Gueguen-Chaignon, V.,Salomon-Mallet, M.,Guillot, A.,Guerardel, Y.,Chapot-Chartier, M.P.,Grangeasse, C.,Leulier, F. Structure-function analysis of Lactiplantibacillus plantarum DltE& reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth. Elife 2023 12 0 0 8BF4 37088134 Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14 2022-10-24 2023-05-03 Cowan, R.,Trokter, M.,Oleksy, A.,Fedorova, M.,Sawmynaden, K.,Worzfeld, T.,Offermanns, S.,Matthews, D.,Carr, M.D.,Hall, G. Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. J.Biol.Chem. 2023 299 104740 104740 8CBX 37100101 Crystal Structure of Anti-Cortisol Fab fragment 2023-01-26 2023-05-10 Eronen, V.,Tullila, A.,Iljin, K.,Rouvinen, J.,Nevanen, T.K.,Hakulinen, N. Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids. J.Struct.Biol. 2023 215 107966 107966 8CBY 37100101 Crystal Structure of Anti-cortisol Fab in Complex with Cortisol 2023-01-26 2023-05-10 Eronen, V.,Tullila, A.,Iljin, K.,Rouvinen, J.,Nevanen, T.K.,Hakulinen, N. Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids. J.Struct.Biol. 2023 215 107966 107966 8CBZ 37100101 Crystal Structure of Anti-cortisol Fab in Complex with Corticosterone 2023-01-26 2023-05-10 Eronen, V.,Tullila, A.,Iljin, K.,Rouvinen, J.,Nevanen, T.K.,Hakulinen, N. Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids. J.Struct.Biol. 2023 215 107966 107966 8CC0 37100101 Crystal Structure of Anti-cortisol Fab in Complex with Cortisone 2023-01-26 2023-05-10 Eronen, V.,Tullila, A.,Iljin, K.,Rouvinen, J.,Nevanen, T.K.,Hakulinen, N. Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids. J.Struct.Biol. 2023 215 107966 107966 8CC1 37100101 Crystal Structure of Anti-cortisol Fab in Complex with Prednisolone 2023-01-26 2023-05-10 Eronen, V.,Tullila, A.,Iljin, K.,Rouvinen, J.,Nevanen, T.K.,Hakulinen, N. Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids. J.Struct.Biol. 2023 215 107966 107966 7ZQU A fast recovering full-length LOV protein (DsLOV) from the marine phototrophic bacterium Dinoroseobacter shibae (Dark state) - C72A mutant 2022-05-03 2023-05-17 Batra-Safferling, R.,Granzin, J. A fast recovering full-length LOV protein (DsLOV) from the marine phototrophic bacterium Dinoroseobacter shibae (Dark state) - C72A mutant To Be Published 0 0 0 0 7Q8E Crystal Structure of the MurT-GatD Enzyme Complex from Staphylococcus aureus COL strain 2021-11-11 2023-05-24 Leisico, F.,Romao, M.J.,Santos-Silva, T. Crystal Structure of the MurT-GatD Enzyme Complex from Staphylococcus aureus COL strain To Be Published 0 0 0 0 7YX0 38280482 Crystal structure of the full-length short LOV protein SBW25-LOV from Pseudomonas fluorescens (light state) 2022-02-15 2023-05-24 Arinkin, V.,Granzin, J.,Jaeger, K.E.,Willbold, D.,Krauss, U.,Batra-Safferling, R. Conserved Signal Transduction Mechanisms and Dark Recovery Kinetic Tuning in the Pseudomonadaceae Short Light, Oxygen, Voltage (LOV) Protein Family. J.Mol.Biol. 2024 0 168458 168458 7ZV6 Crystal Structure of Aichivirus A 2A protein 2022-05-13 2023-05-24 von Castelmur, E.,Perrakis, A. Structural and functional repurposing of picornavirus H/NC-motif 2A proteins To Be Published 0 0 0 0 7ZV6 Crystal Structure of Aichivirus A 2A protein 2022-05-13 2023-05-24 von Castelmur, E.,Perrakis, A. Structural and functional repurposing of picornavirus H/NC-motif 2A proteins To Be Published 0 0 0 0 8BSA 37365341 Vc1313-LBD bound to D-arginine 2022-11-24 2023-06-07 Irazoki, O.,Ter Beek, J.,Alvarez, L.,Mateus, A.,Colin, R.,Typas, A.,Savitski, M.M.,Sourjik, V.,Berntsson, R.P.,Cava, F. D-amino acids signal a stress-dependent run-away response in Vibrio cholerae. Nat Microbiol 2023 8 1549 1560 7QF8 37963862 Crystal structure of a bacterial pyranose 2-oxidase from Pseudoarthrobacter siccitolerans 2021-12-04 2023-06-14 Taborda, A.,Frazao, T.,Rodrigues, M.V.,Fernandez-Luengo, X.,Sancho, F.,Lucas, M.F.,Frazao, C.,Melo, E.P.,Ventura, M.R.,Masgrau, L.,Borges, P.T.,Martins, L.O. Mechanistic insights into glycoside 3-oxidases involved in C-glycoside metabolism in soil microorganisms. Nat Commun 2023 14 7289 7289 8AEV 36193860 Human acetylcholinesterase in complex with N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium 2022-07-13 2023-06-14 Nachon, F.,Brazzolotto, X.,Dias, J.,Courageux, C.,Drozdz, W.,Cao, X.Y.,Stefankiewicz, A.R.,Lehn, J.M. Grid-Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions. Chembiochem 2022 23 0 0 8CHX 37095149 Structure and function of LolA from Vibrio cholerae 2023-02-08 2023-06-21 Jaiman, D.,Nagampalli, R.,Persson, K. A comparative analysis of lipoprotein transport proteins: LolA and LolB from Vibrio cholerae and LolA from Porphyromonas gingivalis. Sci Rep 2023 13 6605 6605 8CP2 37302552 Structure of Aspartate-N-hydroxylase (FzmM)from Streptomyces sp. V2: complex with NADPH and L-aspartate 2023-03-01 2023-07-12 Rotilio, L.,Boverio, A.,Nguyen, Q.T.,Mannucci, B.,Fraaije, M.W.,Mattevi, A. A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center. J.Biol.Chem. 2023 299 104904 104904 8JUK Crystal structure of Adenosine triphosphate phosphoribosyltransferase from Acinetobacter baumannii at 2.18 A resolution 2023-06-26 2023-07-12 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Crystal structure of Adenosine triphosphate phosphoribosyltransferase from Acinetobacter baumannii at 2.18 A resolution To Be Published 0 0 0 0 7ZCB 37490546 Human Pikachurin/EGFLAM N-terminal Fibronectin-III (1-2) domains 2022-03-26 2023-07-19 Patil, D.N.,Pantalone, S.,Cao, Y.,Laboute, T.,Novick, S.J.,Singh, S.,Savino, S.,Faravelli, S.,Magnani, F.,Griffin, P.R.,Singh, A.K.,Forneris, F.,Martemyanov, K.A. Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179. Sci.Signal. 2023 16 0 0 8C7S 37326020 Transcriptional pleiotropic repressor CodY from Staphylococcus aureus in complex with Ile, GTP, and a 30-bp DNA fragment encompassing two overlapping binding sites 2023-01-17 2023-07-19 Hainzl, T.,Bonde, M.,Almqvist, F.,Johansson, J.,Sauer-Eriksson, A.E. Structural insights into CodY activation and DNA recognition. Nucleic Acids Res. 2023 51 7631 7648 8ONE 37446392 Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with Fe2+, Mn2+, UDP-Glucose 2023-04-02 2023-07-19 Mattoteia, D.,Chiapparino, A.,Fumagalli, M.,De Marco, M.,De Giorgi, F.,Negro, L.,Pinnola, A.,Faravelli, S.,Roscioli, T.,Scietti, L.,Forneris, F. Identification of Regulatory Molecular ""Hot Spots"" for LH/PLOD Collagen Glycosyltransferase Activity. Int J Mol Sci 2023 24 0 0 8OIA 37482279 Trichomonas vaginalis riboside hydrolase in complex with D-ribose 2023-03-22 2023-08-02 Patrone, M.,Galasyn, G.S.,Kerin, F.,Nyitray, M.M.,Parkin, D.W.,Stockman, B.J.,Degano, M. A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis. J.Biol.Chem. 2023 299 105077 105077 8OR6 37513201 Crystal structure of Drosophila melanogaster alpha-amylase 2023-04-13 2023-08-09 Rhimi, M.,Da Lage, J.L.,Haser, R.,Feller, G.,Aghajari, N. Structural and Functional Characterization of Drosophila melanogaster alpha-Amylase. Molecules 2023 28 0 0 8AHD The apo structure of the Corramycin phosphotransferase 2022-07-21 2023-08-16 Adam, S.,Mueller, R.,Koehnke, J. The apo structure of the Corramycin phosphotransferase To Be Published 0 0 0 0 8AMC Crystal Structure of cat allergen Fel d 4 2022-08-03 2023-08-16 Schooltink, L.,Sagmeister, T.,Gottstein, N.,Pavkov-Keller, T.,Keller, W. Crystal Structure of cat allergen Fel d 4 To Be Published 0 0 0 0 8GMX Crystal structure of pilin-specific sortase SrtC2 from Lactobacillus rhamnosus GG 2022-08-22 2023-08-30 Das, S.,Megta, A.K.,Pratap, S.,Krishnan, V. Crystal structure of pilin-specific sortase SrtC2 from Lactobacillus rhamnosus GG To Be Published 0 0 0 0 8ORA 37466248 Human holo aromatic L-amino acid decarboxylase (AADC) external aldimine with L-Dopa methylester 2023-04-13 2023-08-30 Bisello, G.,Ribeiro, R.P.,Perduca, M.,Belviso, B.D.,Polverino De' Laureto, P.,Giorgetti, A.,Caliandro, R.,Bertoldi, M. Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency. Protein Sci. 2023 32 0 0 8OFW 37278160 Crystal structure of the full-length dihydroorotate dehydrogenase from Mycobacterium tuberculosis 2023-03-17 2023-09-06 Alberti, M.,Sainas, S.,Ronchi, E.,Lolli, M.L.,Boschi, D.,Rizzi, M.,Ferraris, D.M.,Miggiano, R. Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor. Febs Lett. 2023 597 2119 2132 8AXR Crystal structure of the C-terminal domain of human CFAP410 2022-08-31 2023-09-13 Dong, G.,Stadler, A. Structural studies of cilia and flagella associated protein 410 (CFAP410) reveal its bimodular organization with an N-terminal LRR motif and a C-terminal tetrameric helical bundle To Be Published 0 0 0 0 8APS 37676236 Small molecular stabilizer for ERalpha and 14-3-3 (1083744) 2022-08-10 2023-09-20 Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.,Chen, S.,Jaishankar, P.,Overmans, M.,Dutta, S.,Neitz, R.J.,Renslo, A.R.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc. 2023 145 20328 20343 8AQ1 37676236 small molecule stabilizer for ERalpha and 14-3-3 (1083743) 2022-08-11 2023-09-20 Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.,Chen, S.,Jaishankar, P.,Overmans, M.,Dutta, S.,Neitz, R.J.,Renslo, A.R.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc. 2023 145 20328 20343 8ATR 37676236 Small molecular stabilizer for C-RAF (pS259) and 14-3-3 (1075297) 2022-08-24 2023-09-20 Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.,Chen, S.,Jaishankar, P.,Overmans, M.,Dutta, S.,Neitz, R.J.,Renslo, A.R.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc. 2023 145 20328 20343 8ODS Phosphate-Binding Protein (PstS) from Xanthomonas citri pv. citri A306 bound to phosphate 2023-03-09 2023-10-11 Santos, L.S.,Balan, A.,Guskov, A. Phosphate-Binding Protein (PstS) from Xanthomonas citri pv. citri A306 To Be Published 0 0 0 0 8OXV 37798283 Transglutaminase 3 zymogen in complex with DH patient-derived Fab DH63-B02 2023-05-02 2023-10-18 Heggelund, J.E.,Das, S.,Stamnaes, J.,Iversen, R.,Sollid, L.M. Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3. Nat Commun 2023 14 6216 6216 8PBE 37540500 Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 2023-06-09 2023-11-01 Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis 2023 46 1170 1185 8PBG 37540500 Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate 2023-06-09 2023-11-01 Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis 2023 46 1170 1185 8PBH 37540500 Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 2023-06-09 2023-11-01 Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis 2023 46 1170 1185 8PBI 37540500 Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate 2023-06-09 2023-11-01 Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis 2023 46 1170 1185 8PBJ 37540500 Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 2023-06-09 2023-11-01 Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis 2023 46 1170 1185 8PBK 37540500 Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate 2023-06-09 2023-11-01 Del Cano-Ochoa, F.,Ng, B.G.,Rubio-Del-Campo, A.,Mahajan, S.,Wilson, M.P.,Vilar, M.,Rymen, D.,Sanchez-Pintos, P.,Kenny, J.,Ley Martos, M.,Campos, T.,Wortmann, S.B.,Freeze, H.H.,Ramon-Maiques, S. Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis 2023 46 1170 1185 8QFE 38185322 Cryogenic crystal structure of the Photoactivated Adenylate Cyclase OaPAC 2023-09-04 2023-11-01 Chretien, A.,Nagel, M.F.,Botha, S.,de Wijn, R.,Brings, L.,Dorner, K.,Han, H.,Koliyadu, J.C.P.,Letrun, R.,Round, A.,Sato, T.,Schmidt, C.,Secareanu, R.C.,von Stetten, D.,Vakili, M.,Wrona, A.,Bean, R.,Mancuso, A.,Schulz, J.,Pearson, A.R.,Kottke, T.,Lorenzen, K.,Schubert, R. Light-induced Trp in /Met out Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC. J.Mol.Biol. 2024 436 168439 168439 8QFF 38185322 Cryogenic crystal structure of the Photoactivated Adenylate Cyclase OaPAC with ATP bound 2023-09-11 2023-11-01 Chretien, A.,Nagel, M.F.,Botha, S.,de Wijn, R.,Brings, L.,Dorner, K.,Han, H.,Koliyadu, J.C.P.,Letrun, R.,Round, A.,Sato, T.,Schmidt, C.,Secareanu, R.C.,von Stetten, D.,Vakili, M.,Wrona, A.,Bean, R.,Mancuso, A.,Schulz, J.,Pearson, A.R.,Kottke, T.,Lorenzen, K.,Schubert, R. Light-induced Trp in /Met out Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC. J.Mol.Biol. 2024 436 168439 168439 8QZG 38351082 1,3 L,D-transpeptidase from Gluconobacter oxydans 2023-10-27 2023-11-08 Espaillat, A.,Alvarez, L.,Torrens, G.,Ter Beek, J.,Miguel-Ruano, V.,Irazoki, O.,Gago, F.,Hermoso, J.A.,Berntsson, R.P.,Cava, F. A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha- and Betaproteobacteria. Nat Commun 2024 15 1343 1343 7ZRR Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK965 2022-05-05 2023-11-15 Caregnato, A.,Angela, P.,Mazzoccato, Y.,Frasson, N.,Angelini, A.,Cendron, L. Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK965 To Be Published 0 0 0 0 7ZRT Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970 2022-05-05 2023-11-15 Caregnato, A.,Angela, P.,Mazzoccato, Y.,Frasson, N.,Angelini, A.,Cendron, L. Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970 To Be Published 0 0 0 0 8QMK 37962296 Enzymatically-produced complex-B bound TmHydE structure 2023-09-22 2023-11-22 Omeiri, J.,Martin, L.,Usclat, A.,Cherrier, M.V.,Nicolet, Y. Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the ( kappa 3 -cysteinate)Fe II (CN)(CO) 2 Complex B from HydG to HydE. Angew.Chem.Int.Ed.Engl. 2023 62 0 0 8BBX 38059672 Structure of prolyl endoprotease from Aspergillus niger CBS 109712 in space group C222(1) 2022-10-14 2023-12-20 Pijning, T.,Vujicic-Zagar, A.,van der Laan, J.M.,de Jong, R.M.,Ramirez-Palacios, C.,Vente, A.,Edens, L.,Dijkstra, B.W. Structural and time-resolved mechanistic investigations of protein hydrolysis by the acidic proline-specific endoprotease from Aspergillus niger. Protein Sci. 2024 33 0 0 8C0D 38383789 UFL1/DDRGK1 bound to UFC1 2022-12-16 2023-12-27 Makhlouf, L.,Peter, J.J.,Magnussen, H.M.,Thakur, R.,Millrine, D.,Minshull, T.C.,Harrison, G.,Varghese, J.,Lamoliatte, F.,Foglizzo, M.,Macartney, T.,Calabrese, A.N.,Zeqiraj, E.,Kulathu, Y. The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Nature 2024 627 437 444 8PQB 38167404 c-KIT kinase domain in complex with avapritinib derivative 8 2023-07-11 2023-12-27 Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D. Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun 2024 15 63 63 8PQC 38167404 c-KIT kinase domain in complex with avapritinib derivative 9 2023-07-11 2023-12-27 Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D. Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun 2024 15 63 63 8CN2 Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide 2023-02-21 2024-01-10 Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R. New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv 2023 0 0 0 8CN5 Pa.FabF-C164Q in complex with propan-2-yl 1~{H}-pyrazole-3-carboxylate 2023-02-22 2024-01-10 Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R. New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv 2023 0 0 0 8CN7 Pa.FabF-C164Q in complex with platencin 2023-02-22 2024-01-10 Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R. New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv 2023 0 0 0 8OVY 38200312 Structure of analogue of superfolded GFP 2023-04-26 2024-01-10 Dunkelmann, D.L.,Piedrafita, C.,Dickson, A.,Liu, K.C.,Elliott, T.S.,Fiedler, M.,Bellini, D.,Zhou, A.,Cervettini, D.,Chin, J.W. Adding alpha , alpha-disubstituted and beta-linked monomers to the genetic code of an organism. Nature 2024 625 603 610 8P4L 38129294 Beta-N-acetylgalactosaminidase from Niabella aurantiaca 2023-05-22 2024-01-17 Moreno Prieto, E.S.,Fjermedal, S.,Siebenhaar, S.,Vuillemin, M.,Holck, J.,Vincentelli, R.,Gippert, G.P.,Wilkens, C.,Morth, J.P.,Henrissat, B. Characterization and structural study of a novel beta-N-acetylgalactosaminidase from Niabella aurantiaca. Febs J. 2024 291 1439 1456 8OGI 38229400 Structure of native human eosinophil peroxidase 2023-03-20 2024-01-24 Pfanzagl, V.,Gruber-Grunwald, C.,Leitgeb, U.,Furtmuller, P.G.,Obinger, C. Posttranslational modification and heme cavity architecture of human eosinophil peroxidase-insights from first crystal structure and biochemical characterization. J.Biol.Chem. 2023 299 105402 105402 8C62 38270175 Crystal structure of cisplatin/B-DNA adduct 2023-01-11 2024-01-31 Troisi, R.,Tito, G.,Ferraro, G.,Sica, F.,Massai, L.,Geri, A.,Cirri, D.,Messori, L.,Merlino, A. On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer. Dalton Trans 2024 53 3476 3483 8I8N Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Dephosphocoenzyme-A and Phosphonoacetic acid at 2.22 A resolution. 2023-02-04 2024-02-07 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Dephosphocoenzyme-A and Phosphonoacetic acid at 2.22 A resolution. To Be Published 0 0 0 0 8I8O Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Dephosphocoenzyme-A and Phosphonoacetic acid at 2.41 A resolution. 2023-02-04 2024-02-07 Ahmad, N.,Sharma, P.,Sharma, S.,Singh, T.P. Crystal structure of the ternary complex of Phosphopantetheine adenylyltransferase (PPAT) from Enterobacter sp. with Dephosphocoenzyme-A and Phosphonoacetic acid at 2.41 A resolution. To Be Published 0 0 0 0 8PEA OXA-48_F72L. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution 2023-06-13 2024-02-14 Frohlich, C.,Leiros, H.-K.S. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution. To Be Published 2024 0 0 0 8CLO 38449531 Zearalenone lactonase from Streptomyces coelicoflavus 2023-02-17 2024-02-21 Fruhauf, S.,Puhringer, D.,Thamhesl, M.,Fajtl, P.,Kunz-Vekiru, E.,Hobartner-Gussl, A.,Schatzmayr, G.,Adam, G.,Damborsky, J.,Djinovic-Carugo, K.,Prokop, Z.,Moll, W.D. Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone. Acs Catalysis 2024 14 3392 3410 8P5Q Structure of an ALOG domain from Arabidopsis thaliana in complex with DNA 2023-05-24 2024-02-21 Rieu, P.,Lucas, J.,Thevenon, E.,Dumas, R.,Beretta, V.,Caselli, F.,Franchini, E.,Caporali, E.,Kater, M.,Zubieta, C.,Nanao, M.H.,Gregis, V.,Parcy, F. Structure of an ALOG domain from Arabidopsis thaliana in complex with DNA To Be Published 0 0 0 0 8PPI 38374076 Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with beta-D-glucopyranosylmethanol 3,4,1'-trisphosphate/ATP/Mn 2023-07-07 2024-02-28 Marquez-Monino, M.A.,Ortega-Garcia, R.,Whitfield, H.,Riley, A.M.,Infantes, L.,Garrett, S.W.,Shipton, M.L.,Brearley, C.A.,Potter, B.V.L.,Gonzalez, B. Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun 2024 15 1502 1502 8QAO Crystal structure of TP901-1 CI-NTD89 repressor N-terminal domain 2023-08-23 2024-02-28 Varming, A.K.,Huang, Z.,Hamad, G.M.,Rasmussen, K.K.,Ingmer, H.,Kilstrup, M.,Lo Leggio, L. CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus phi 13 bacteriophages Microbiome Res Rep 2024 0 0 0 8QCJ 38372589 Crystal structure of mycothiol disulfide reductase Mtr from Rhodococcus erythropolis 2023-08-27 2024-03-13 Gutierrez-Fernandez, J.,Hersleth, H.P.,Hammerstad, M. The crystal structure of mycothiol disulfide reductase (Mtr) provides mechanistic insight into the specific low-molecular-weight thiol reductase activity of Actinobacteria. Acta Crystallogr D Struct Biol 2024 80 181 193 8PUM Tha1 L-threonine aldolase (mouse), monoclinic form (C2) 2023-07-17 2024-03-20 Battistutta, R.,Fornasier, E.,Giachin, G. Tha1 L-threonine aldolase (mouse), monoclinic form (C2) To Be Published 0 0 0 0 8PUS Tha1 L-threonine aldolase (mouse), orthorhombic form (F222) 2023-07-17 2024-03-20 Battistutta, R.,Fornasier, E.,Giachin, G. Tha1 L-threonine aldolase (mouse), orthorhombic form (F222) To Be Published 0 0 0 0 8CRA Structure of the keratin-like domain of SEPALLATA3 and AGAMOUS from Arabidopsis thaliana 2023-03-08 2024-03-27 Zubieta, C.,Hugouvieux, V. Structure of the keratin-like domain of SEPALLATA3 and AGAMOUS from Arabidopsis thaliana To Be Published 0 0 0 0 8OZO Populus tremula stable protein 1 with N-terminal binding peptide extension 2023-05-09 2024-03-27 Sklyar, J.,Zeibaq, Y.,Bachar, O.,Yehezkeli, O.,Adir, N. A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties Small Science 2024 0 0 0 8OZS Populus tremula stable protein 1 with N-terminal binding peptide extension with hemin 2023-05-09 2024-03-27 Sklyar, J.,Zeibaq, Y.,Bachar, O.,Yehezkeli, O.,Adir, N. A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties Small Science 2023 0 0 0 8R0J 38487369 Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl guanylhydrazone, 2a 2023-10-31 2024-03-27 Fagnani, E.,Boni, F.,Seneci, P.,Gornati, D.,Muzio, L.,Mastrangelo, E.,Milani, M. Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface. Comput Struct Biotechnol J 2024 23 1088 1093 8B4G Structure of a fungal LPMO bound to ligands 2022-09-20 2024-04-03 Banerjee, S.,Huang, Z.,Brander, S.,Johansen, K.S.,Lo Leggio, L. Structure of a fungal LPMO bound to ligands To Be Published 0 0 0 0 8PB8 38548735 PsiM in complex with SAH 2023-06-08 2024-04-03 Hudspeth, J.,Rogge, K.,Dorner, S.,Mull, M.,Hoffmeister, D.,Rupp, B.,Werten, S. Methyl transfer in psilocybin biosynthesis. Nat Commun 2024 15 2709 2709 8IZJ Crystal structure of Escherichia coli Adenine Phosphoribosyltransferase (APRT) in complex with AMP 2023-04-07 2024-04-10 Yadav, P.,Kushwaha, G.S.,Bhavesh, N.S. Crystal structure of Escherichia coli Adenine Phosphoribosyltransferase (APRT) in complex with AMP To Be Published 0 0 0 0 8RON Crystal structure of human FAD synthase, isoform 2 2024-01-11 2024-04-10 Leo, G.,Leone, P.,Ataie Kachoiie, E.,Tolomeo, M.,Galluccio, M.,Indiveri, C.,Barile, M.,Capaldi, S. Structural insights into the bifunctional enzyme human FAD synthase Structure 2024 0 0 0 8Q9P 38492719 Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC5 deacetylase binding motif 2023-08-20 2024-04-17 Chinellato, M.,Perin, S.,Carli, A.,Lastella, L.,Biondi, B.,Borsato, G.,Di Giorgio, E.,Brancolini, C.,Cendron, L.,Angelini, A. Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol. 2024 436 168541 168541 8JFF 37805153 Crystal structure of Catabolite repressor acivator from E. coli in complex with HEPES 2023-05-18 2024-04-24 Neetu, N.,Mahto, J.K.,Sharma, M.,Katiki, M.,Dhaka, P.,Roy, P.,Tomar, S.,Narayan, A.,Yernool, D.,Kumar, P. Sulisobenzone is a potent inhibitor of the global transcription factor Cra. J.Struct.Biol. 2023 215 108034 108034 8RM6 38604378 Crystal Structure of Human Androgen Receptor DNA Binding Domain Bound to its Response Element: C3(1)ARE 2024-01-05 2024-04-24 Lee, X.Y.,Van Eynde, W.,Helsen, C.,Willems, H.,Peperstraete, K.,De Block, S.,Voet, A.,Claessens, F. Structural mechanism underlying variations in DNA binding by the androgen receptor. J.Steroid Biochem.Mol.Biol. 2024 241 106499 106499 9F0G LmCpfC H182A variant in complex with iron coproporhyrin III 2024-04-16 2024-04-24 Gabler, T.,Hofbauer, S. LmCpfC H182A variant in complex with iron coproporhyrin III To Be Published 0 0 0 0 8BWE 38405965 Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43) 2022-12-06 2024-05-01 Katz, L.S.,Visser, E.J.,Plitzko, K.F.,Pennings, M.,Cossar, P.J.,Tse, I.L.,Kaiser, M.,Brunsveld, L.,Scott, D.K.,Ottmann, C. Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv 2024 0 0 0 8BWH 38405965 Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42) 2022-12-06 2024-05-01 Katz, L.S.,Visser, E.J.,Plitzko, K.F.,Pennings, M.,Cossar, P.J.,Tse, I.L.,Kaiser, M.,Brunsveld, L.,Scott, D.K.,Ottmann, C. Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv 2024 0 0 0 8J9T Crystal Structure of GyraseA N-terminal at 2.43A Resolution 2023-05-04 2024-05-08 Salman, M.,Sachdeva, E.,Das, U.,Singh, T.P.,Ethayathullah, A.S.,Kaur, P. Crystal Structure of GyraseA N-terminal at 2.43A Resolution to be published 0 0 0 0