PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 1B7D 10388565 NEUROTOXIN (TS1) FROM BRAZILIAN SCORPION TITYUS SERRULATUS 1999-01-21 1999-07-22 Polikarpov, I.,Junior, M.S.,Marangoni, S.,Toyama, M.H.,Teplyakov, A. Crystal structure of neurotoxin Ts1 from Tityus serrulatus provides insights into the specificity and toxicity of scorpion toxins. J.Mol.Biol. 1999 290 175 184 1DI0 10764570 CRYSTAL STRUCTURE OF LUMAZINE SYNTHASE FROM BRUCELLA ABORTUS 1999-11-28 2000-04-24 Braden, B.C.,Velikovsky, C.A.,Cauerhff, A.A.,Polikarpov, I.,Goldbaum, F.A. Divergence in macromolecular assembly: X-ray crystallographic structure analysis of lumazine synthase from Brucella abortus. J.Mol.Biol. 2000 297 1031 1036 1QLL 11141053 Piratoxin-II (Prtx-II) - a K49 PLA2 from Bothrops pirajai 1999-09-01 2000-09-07 Lee, W.H.,Da Silva Giotto, M.T.,Marangoni, S.,Toyama, M.H.,Polikarpov, I.,Garratt, R.C. Structural Basis for Low Catalytic Activity in Lys49 Phospholipases A2-A Hypothesis: The Crystal Structure of Piratoxin II Complexed to Fatty Acid Biochemistry 2001 40 28 0 1QLR 11086081 CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A HUMAN MONOCLONAL IgM COLD AGGLUTININ 1999-09-11 2000-09-14 Cauerhff, A.,Braden, B.C.,Carvalho, J.G.,Aparicio, R.,Polikarpov, I.,Leoni, J.,Goldbaum, F.A. Three-dimensional structure of the Fab from a human IgM cold agglutinin. J Immunol. 2000 165 6422 6428 1DN0 11086081 STRUCTURE OF THE FAB FRAGMENT FROM A HUMAN IGM COLD AGGLUTININ 1999-12-15 2001-01-24 Cauerhff, A.,Braden, B.C.,Carvalho, J.G.,Aparicio, R.,Polikarpov, I.,Leoni, J.,Goldbaum, F.A. Three-dimensional structure of the Fab from a human IgM cold agglutinin. J.Immunol. 2000 165 6422 6428 1QG5 11168385 HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORM A) 1999-04-20 2001-04-21 Oliveira, K.M.,Valente-Mesquita, V.L.,Botelho, M.M.,Sawyer, L.,Ferreira, S.T.,Polikarpov, I. Crystal structures of bovine beta-lactoglobulin in the orthorhombic space group C222(1). Structural differences between genetic variants A and B and features of the Tanford transition. Eur.J.Biochem. 2001 268 477 483 1B8E 11168385 HIGH RESOLUTION CRYSTAL STRUCTURE OF THE BOVINE BETA-LACTOGLOBULIN (ISOFORMS A AND B) IN ORTHOROMBIC SPACE GROUP 1999-01-30 2001-05-02 Oliveira, K.M.,Valente-Mesquita, V.L.,Botelho, M.M.,Sawyer, L.,Ferreira, S.T.,Polikarpov, I. Crystal structures of bovine beta-lactoglobulin in the orthorhombic space group C222(1). Structural differences between genetic variants A and B and features of the Tanford transition. Eur.J.Biochem. 2001 268 477 483 1IG8 10749890 Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence 2001-04-17 2001-05-02 Kuser, P.R.,Krauchenco, S.,Antunes, O.A.,Polikarpov, I. The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action. J.Biol.Chem. 2000 275 20814 20821 1FHJ 14683506 CRYSTAL STRUCTURE OF AQUOMET HEMOGLOBIN-I OF THE MANED WOLF (CHRYSOCYON BRACHYURUS) AT 2.0 RESOLUTION. 2000-08-01 2001-08-01 Fadel, V.,Canduri, F.,Olivieri, J.R.,Smarra, A.L.,Colombo, M.F.,Bonilla-Rodriguez, G.O.,de Azevedo, W.F. Crystal structure of hemoglobin from the maned wolf (Chrysocyon brachyurus) using synchrotron radiation. Protein Pept.Lett. 2003 10 551 559 1FLH 11679720 CRYSTAL STRUCTURE OF HUMAN UROPEPSIN AT 2.45 A RESOLUTION 2000-08-14 2001-10-31 Canduri, F.,Teodoro, L.G.,Fadel, V.,Lorenzi, C.C.,Hial, V.,Gomes, R.A.,Neto, J.R.,de Azevedo, W.F. Structure of human uropepsin at 2.45 A resolution. Acta Crystallogr.,Sect.D 2001 57 1560 1570 1GMZ 12554936 Crystal structure of the D49 phospholipase A2 piratoxin III from Bothrops pirajai. 2001-09-27 2001-11-01 Rigden, D.J.,Hwa, L.,Marangoni, S.,Toyama, M.,Polikarpov, I. The Structure of the D49 Phospholipase A2 Piratoxin III from Bothrops Pirajai Reveals Unprecedented Structural Displacement of the Calcium-Binding Loop: Possible Relationship to Cooperative Substrate Binding Acta Crystallogr.,Sect.D 2003 59 255 0 1II2 11700062 Crystal Structure of Phosphoenolpyruvate Carboxykinase (PEPCK) from Trypanosoma cruzi 2001-04-20 2001-11-21 Trapani, S.,Linss, J.,Goldenberg, S.,Fischer, H.,Craievich, A.F.,Oliva, G. Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution. J.Mol.Biol. 2001 313 1059 1072 1JV4 11717500 Crystal structure of recombinant major mouse urinary protein (rmup) at 1.75 A resolution 2001-08-28 2001-12-05 Kuser, P.R.,Franzoni, L.,Ferrari, E.,Spisni, A.,Polikarpov, I. The X-ray structure of a recombinant major urinary protein at 1.75 A resolution. A comparative study of X-ray and NMR-derived structures. Acta Crystallogr.,Sect.D 2001 57 1863 1869 1JLH 12573240 Human Glucose-6-phosphate Isomerase 2001-07-16 2003-02-11 Cordeiro, A.T.,Godoi, P.H.C.,Silva, C.H.T.P.,Garratt, R.C.,Oliva, G.,Thiemann, O.H. Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps BIOCHIM.BIOPHYS.ACTA 2003 1645 117 122 1NPI 12595696 Tityus Serrulatus Neurotoxin (Ts1) at atomic resolution 2003-01-17 2003-02-25 Pinheiro, C.B.,Marangoni, S.,Toyama, M.H.,Polikarpov, I. Structural analysis of Tityus serrulatus Ts1 neurotoxin at atomic resolution: insights into interactions with Na+ channels. Acta Crystallogr.,Sect.D 2003 59 405 415 1NNS 12595697 L-asparaginase of E. coli in C2 space group and 1.95 A resolution 2003-01-14 2003-03-11 Sanches, M.,Barbosa, J.A.R.G.,de Oliveira, R.T.,Abrahao Neto, J.,Polikarpov, I. Structural comparison of Escherichia coli L-asparaginase in two monoclinic space groups. Acta Crystallogr.,Sect.D 2003 59 416 422 1KD2 Crystal Structure of Human Deoxyhemoglobin in Absence of Any Anions 2001-11-12 2003-06-10 Seixas, F.A.V.,Azevedo Jr, W.F.,Colombo, M.F. The X-Ray Structure of Iso-Ionic Deoxy-Hb Crystal: The High Affinity T-state of Human Hb and the Mechanism of Chloride Regulation of Hb Cooperative Oxygen Binding. To be Published 0 0 0 0 1HWU 12084071 STRUCTURE OF PII PROTEIN FROM HERBASPIRILLUM SEROPEDICAE 2001-01-10 2003-06-17 Machado Benelli, E.,Buck, M.,Polikarpov, I.,Maltempi de Souza, E.,Cruz, L.M.,Pedrosa, F.O. Herbaspirillum seropedicae signal transduction protein PII is structurally similar to the enteric GlnK. Eur.J.Biochem. 2002 269 3296 3303 1M4R 12176383 CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22 2002-07-03 2003-07-07 Nagem, R.A.P.,Colau, D.,Dumoutier, L.,Renauld, J.-C.,Ogata, C.,Polikarpov, I. 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Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine Arch.Biochem.Biophys. 2005 442 49 58 2CWM 16337811 Native Crystal Structure of NO releasing inductive lectin from seeds of the Canavalia maritima (ConM) 2005-06-22 2006-01-17 Gadelha, C.A.A.,Moreno, F.B.M.B.,Santi-Gadelha, T.,Cajazeiras, J.B.,Rocha, B.A.M.,Assreuy, A.M.S.,Lima Mota, M.R.,Pinto, N.V.,Passos Meireles, A.V.,Borges, J.C.,Freitas, B.T.,Canduri, F.,Souza, E.P.,Delatorre, P.,Criddle, D.N.,De Azevedo Jr., W.F.,Cavada, B.S. Native crystal structure of a nitric oxide-releasing lectin from the seeds of Canavalia maritima J.Struct.Biol. 2005 152 185 194 1YRR 16630633 Crystal Structure Of The N-Acetylglucosamine-6-Phosphate Deacetylase From Escherichia Coli K12 at 2.0 A Resolution 2005-02-04 2006-03-21 Ferreira, F.M.,Mendoza-Hernandez, G.,Aparicio, R.,Fischer, H.,Calcagno, M.L.,Oliva, G. Structural analysis of N-acetylglucosamine-6-phosphate deacetylase apoenzyme from Escherichia coli. J.Mol.Biol. 2006 359 308 321 1Z76 16301802 Crystal structure of an acidic phospholipase A2 (BthA-I) from Bothrops jararacussu venom complexed with p-bromophenacyl bromide 2005-03-24 2006-03-21 Magro, A.J.,Takeda, A.A.,Soares, A.M.,Fontes, M.R. Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity. Acta Crystallogr.,Sect.D 2005 61 1670 1677 2F9L 16545962 3D structure of inactive human Rab11b GTPase 2005-12-06 2006-04-04 Scapin, S.M.,Carneiro, F.R.,Alves, A.C.,Medrano, F.J.,Guimaraes, B.G.,Zanchin, N.I. The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. J.Struct.Biol. 2006 154 260 268 2F9M 16545962 3D structure of active human Rab11b GTPase 2005-12-06 2006-04-04 Scapin, S.M.,Carneiro, F.R.,Alves, A.C.,Medrano, F.J.,Guimaraes, B.G.,Zanchin, N.I. The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. J.Struct.Biol. 2006 154 260 268 1WUV 17683532 Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin 2004-12-09 2006-04-18 Delatorre, P.,Rocha, B.A.M.,Souza, E.P.,Oliveira, T.M.,Bezerra, G.A.,Moreno, F.B.M.B.,Freitas, B.T.,Santi-Gadelha, T.,Sampaio, A.H.,Azevedo Jr., W.F.,Cavada, B.S. Structure of a lectin from Canavalia gladiata seeds: new structural insights for old molecules Bmc Struct.Biol. 2007 7 52 52 1ZB9 16631787 Crystal structure of Xylella fastidiosa organic peroxide resistance protein 2005-04-07 2006-04-25 Oliveira, M.A.,Guimaraes, B.G.,Cussiol, J.R.,Medrano, F.J.,Gozzo, F.C.,Netto, L.E. Structural Insights into Enzyme-Substrate Interaction and Characterization of Enzymatic Intermediates of Organic Hydroperoxide Resistance Protein from Xylella fastidiosa. J.Mol.Biol. 2006 359 433 445 1ZL7 16376474 Crystal structure of catalytically-active phospholipase A2 with bound calcium 2005-05-05 2006-04-25 Murakami, M.T.,Gabdoulkhakov, A.,Genov, N.,Cintra, A.C.,Betzel, C.,Arni, R.K. Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states. Biochimie 2006 88 543 549 1ZN8 18399692 Human Adenine Phosphoribosyltransferase Complexed with AMP, in Space Group P1 at 1.76 A Resolution 2005-05-11 2006-04-25 Silva, C.H.,Silva, M.,Iulek, J.,Thiemann, O.H. Structural Complexes of Human Adenine Phosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism J.Biomol.Struct.Dyn. 2008 25 589 598 1ZB8 16631787 Crystal structure of Xylella fastidiosa organic peroxide resistance protein 2005-04-07 2006-05-02 Oliveira, M.A.,Guimaraes, B.G.,Cussiol, J.R.,Medrano, F.J.,Gozzo, F.C.,Netto, L.E. Structural Insights into Enzyme-Substrate Interaction and Characterization of Enzymatic Intermediates of Organic Hydroperoxide Resistance Protein from Xylella fastidiosa. J.Mol.Biol. 2006 359 433 445 1ZTB 16459102 Crystal Structure of Chorismate Synthase from Mycobacterium tuberculosis 2005-05-26 2006-05-16 Dias, M.V.B.,Borges, J.C.,Ely, F.,Pereira, J.H.,Canduri, F.,Ramos, C.H.I.,Frazzon, J.,Palma, M.S.,Basso, L.A.,Santos, D.S.,de Azevedo Jr., W.F. Structure of chorismate synthase from Mycobacterium tuberculosis J.Struct.Biol. 2006 154 130 143 2AQ8 16647717 Crystal structure of wild-type of Enoyl-ACP(CoA) reductase from Mycobacterium tuberculosis in complex with NADH. 2005-08-17 2006-05-23 Oliveira, J.S.,Pereira, J.H.,Canduri, F.,Rodrigues, N.C.,de Souza, O.N.,de Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. Crystallographic and Pre-steady-state Kinetics Studies on Binding of NADH to Wild-type and Isoniazid-resistant Enoyl-ACP(CoA) Reductase Enzymes from Mycobacterium tuberculosis. J.Mol.Biol. 2006 359 646 666 2AQH 16647717 Crystal structure of Isoniazid-resistant I21V Enoyl-ACP(CoA) reductase mutant enzyme from Mycobacterium tuberculosis in complex with NADH 2005-08-18 2006-05-23 Oliveira, J.S.,Pereira, J.H.,Canduri, F.,Rodrigues, N.C.,de Souza, O.N.,de Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. Crystallographic and Pre-steady-state Kinetics Studies on Binding of NADH to Wild-type and Isoniazid-resistant Enoyl-ACP(CoA) Reductase Enzymes from Mycobacterium tuberculosis. J.Mol.Biol. 2006 359 646 666 2AQI 16647717 Crystal structure of Isoniazid-resistant I47T Enoyl-ACP(CoA) reductase mutant enzyme from Mycobacterium tuberculosis in complex with NADH 2005-08-18 2006-05-23 Oliveira, J.S.,Pereira, J.H.,Canduri, F.,Rodrigues, N.C.,de Souza, O.N.,de Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. Crystallographic and Pre-steady-state Kinetics Studies on Binding of NADH to Wild-type and Isoniazid-resistant Enoyl-ACP(CoA) Reductase Enzymes from Mycobacterium tuberculosis. J.Mol.Biol. 2006 359 646 666 2AQK 16647717 Crystal structure of Isoniazid-resistant S94A Enoyl-ACP(CoA) reductase mutant enzyme from Mycobacterium tuberculosis in complex with NADH 2005-08-18 2006-05-23 Oliveira, J.S.,Pereira, J.H.,Canduri, F.,Rodrigues, N.C.,de Souza, O.N.,de Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. Crystallographic and Pre-steady-state Kinetics Studies on Binding of NADH to Wild-type and Isoniazid-resistant Enoyl-ACP(CoA) Reductase Enzymes from Mycobacterium tuberculosis. J.Mol.Biol. 2006 359 646 666 2CY6 16677825 Crystal structure of ConM in complex with trehalose and maltose 2005-07-05 2006-06-13 Delatorre, P.,Rocha, B.A.M.,Gadelha, C.A.A.,Santi-Gadelha, T.,Cajazeiras, J.B.,Souza, E.P.,Nascimento, K.S.,Freire, V.N.,Sampaio, A.H.,Azevedo Jr., W.F.,Cavada, B.S. Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins J.Struct.Biol. 2006 154 280 286 2CYF 16677825 The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose 2005-07-06 2006-06-13 Delatorre, P.,Rocha, B.A.M.,Gadelha, C.A.A.,Santi-Gadelha, T.,Cajazeiras, J.B.,Souza, E.P.,Nascimento, K.S.,Freire, V.N.,Sampaio, A.H.,Azevedo Jr., W.F.,Cavada, B.S. Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins J.Struct.Biol. 2006 154 280 286 2F9R 15654080 Crystal structure of the inactive state of the Smase I, a sphingomyelinase D from Loxosceles laeta venom 2005-12-06 2006-06-27 Murakami, M.T.,Gabdoulkhakov, A.,Fernandes-Pedrosa, M.F.,Tambourgi, D.V.,Arni, R.K. Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D. J.Biol.Chem. 2005 280 13658 13664 2AOZ 16682766 Crystal structure of the myotoxin-II from Atropoides nummifer venom 2005-08-15 2006-07-25 Murakami, M.T.,Melo, C.C.,Angulo, Y.,Lomonte, B.,Arni, R.K. Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom. Acta Crystallogr.,Sect.F 2006 62 423 426 2DFN 17183161 Structure of shikimate kinase from Mycobacterium tuberculosis complexed with ADP and shikimate at 1.9 angstrons of resolution 2006-03-03 2006-09-03 Dias, M.V.,Faim, L.M.,Vasconcelos, I.B.,de Oliveira, J.S.,Basso, L.A.,Santos, D.S.,de Azevedo, W.F. Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis ACTA CRYSTALLOGR.,SECT.F 2007 63 1 6 2B7H Hemoglobin from Cerdocyon thous, a canidae from Brazil, at 2.2 Angstroms resolution 2005-10-04 2006-09-12 Esteves, G.F.,Silva, V.C.,Bloch Jr., C.,Medrano, F.J.,Barbosa, J.A.R.G.,Freitas, S.M. Crystal structure and biophysical characterization of the Cerdocyon thous, a Canidae from Brazil. To be Published 0 0 0 0 2H7W 17011790 Crystal structure of Chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi 2006-06-05 2006-10-10 Figueiredo da Silva, A.A.,Vieira, L.C.,Krieger, M.A.,Goldenberg, S.,Zanchin, N.I.,Guimaraes, B.G. Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi. J.Struct.Biol. 2007 157 416 423 2ERW 22683792 Crystal Structure of Infestin 4, a factor XIIa inhibitor 2005-10-25 2006-10-31 Campos, I.T.,Souza, T.A.,Torquato, R.J.,De Marco, R.,Tanaka-Azevedo, A.M.,Tanaka, A.S.,Barbosa, J.A.R.G. The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure. Acta Crystallogr.,Sect.D 2012 68 695 702 2F59 17854827 Lumazine synthase RibH1 from Brucella abortus (Gene BruAb1_0785, Swiss-Prot entry Q57DY1) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione 2005-11-25 2006-11-28 Klinke, S.,Zylberman, V.,Bonomi, H.R.,Haase, I.,Guimaraes, B.G.,Braden, B.C.,Bacher, A.,Fischer, M.,Goldbaum, F.A. Structural and Kinetic Properties of Lumazine Synthase Isoenzymes in the Order Rhizobiales J.Mol.Biol. 2007 373 664 680 2F3C 22683792 Crystal structure of infestin 1, a Kazal-type serineprotease inhibitor, in complex with trypsin 2005-11-20 2006-12-05 Campos, I.T.,Souza, T.A.,Torquato, R.J.,De Marco, R.,Tanaka-Azevedo, A.M.,Tanaka, A.S.,Barbosa, J.A.R.G. The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure. Acta Crystallogr.,Sect.D 2012 68 695 702 2FBD 16880547 The crystallographic structure of the digestive lysozyme 1 from Musca domestica at 1.90 Ang. 2005-12-09 2006-12-12 Marana, S.R.,Cancado, F.C.,Valero, A.A.,Ferreira, C.,Terra, W.R.,Barbosa, J.A.R.G. Crystallization, data collection and phasing of two digestive lysozymes from Musca domestica. Acta Crystallogr.,Sect.F 2006 62 750 752 2D7F 17683532 Crystal structure of A lectin from canavalia gladiata seeds complexed with alpha-methyl-mannoside and alpha-aminobutyric acid 2005-11-19 2006-12-19 Delatorre, P.,Rocha, B.A.M.,Souza, E.P.,Oliveira, T.M.,Bezerra, G.A.,Moreno, F.B.M.B.,Freitas, B.T.,Santi-Gadelha, T.,Sampaio, A.H.,Azevedo Jr., W.F.,Cavada, B.S. Structure of a lectin from Canavalia gladiata seeds: new structural insights for old molecules Bmc Struct.Biol. 2007 7 52 52 2G81 17142290 Crystal Structure of the Bowman-Birk Inhibitor from Vigna unguiculata Seeds in Complex with Beta-trypsin at 1.55 Angstrons Resolution 2006-03-01 2007-01-02 Barbosa, J.A.R.G.,Silva, L.P.,Teles, R.C.L.,Esteves, G.F.,Azevedo, R.B.,Ventura, M.M.,Freitas, S.M. Crystal Structure of the Bowman-Birk Inhibitor from Vigna unguiculata Seeds in Complex with {beta}-Trypsin at 1.55 A Resolution and Its Structural Properties in Association with Proteinases Biophys.J. 2007 92 1638 1650 2NUH Crystal structure of CutA from the phytopathgen bacterium Xylella fastidiosa 2006-11-09 2007-01-03 Medrano, F.J.,Benedetti, C.E. Crystal structure of CutA from the phytopathgen bacterium Xylella fastidiosa To be published 0 0 0 0 2DFT 17183161 Structure of shikimate kinase from Mycobacterium tuberculosis complexed with ADP and Mg at 2.8 angstrons of resolution 2006-03-03 2007-01-16 Dias, M.V.,Faim, L.M.,Vasconcelos, I.B.,de Oliveira, J.S.,Basso, L.A.,Santos, D.S.,de Azevedo, W.F. Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis ACTA CRYSTALLOGR.,SECT.F 2007 63 1 6 2G85 Crystal structure of chorismate synthase from Mycobacterium tuberculosis at 2.22 angstrons of resolution 2006-03-01 2007-03-01 Dias, M.V.B.,dos Santos, B.B.,Ely, F.,Basso, L.A.,Santos, D.S.,de Azevedo Jr., W.F. Crystal structure of chorismate synthase from Mycobacterium tuberculosis at 2.22 angstron of resolution To be Published 0 0 0 0 2GSJ 16934035 cDNA cloning and 1.75A crystal structure determination of PPL2, a novel chimerolectin from Parkia platycephala seeds exhibiting endochitinolytic activity 2006-04-26 2007-03-13 Cavada, B.S.,Moreno, F.B.,da Rocha, B.A.,de Azevedo Jr., W.F.,Castellon, R.E.R.,Goersch, G.V.,Nagano, C.S.,de Souza, E.P.,Nascimento, K.S.,Radis-Baptista, G.,Delatorre, P.,Leroy, Y.,Toyama, M.H.,Pinto, V.P.,Sampaio, A.H.,Barettino, D.,Debray, H.,Calvete, J.J.,Sanz, L. cDNA cloning and 1.75 A crystal structure determination of PPL2, an endochitinase and N-acetylglucosamine-binding hemagglutinin from Parkia platycephala seeds Febs J. 2006 273 3962 3974 2P3A 17467738 Crystal Structure of the multi-drug resistant mutant subtype B HIV protease complexed with TL-3 inhibitor 2007-03-08 2007-04-24 Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol. 2007 369 1029 1040 2P3A 17467738 Crystal Structure of the multi-drug resistant mutant subtype B HIV protease complexed with TL-3 inhibitor 2007-03-08 2007-04-24 Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol. 2007 369 1029 1040 2P3C 17467738 Crystal Structure of the subtype F wild type HIV protease complexed with TL-3 inhibitor 2007-03-08 2007-04-24 Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol. 2007 369 1029 1040 2P3C 17467738 Crystal Structure of the subtype F wild type HIV protease complexed with TL-3 inhibitor 2007-03-08 2007-04-24 Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol. 2007 369 1029 1040 2P3D 17467738 Crystal Structure of the multi-drug resistant mutant subtype F HIV protease complexed with TL-3 inhibitor 2007-03-08 2007-04-24 Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol. 2007 369 1029 1040 2P3D 17467738 Crystal Structure of the multi-drug resistant mutant subtype F HIV protease complexed with TL-3 inhibitor 2007-03-08 2007-04-24 Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol. 2007 369 1029 1040 2H9T 19332154 Crystal structure of human alpha-thrombin in complex with suramin 2006-06-11 2007-05-22 Lima, L.M.,Becker, C.F.,Giesel, G.M.,Marques, A.F.,Cargnelutti, M.T.,de Oliveira Neto, M.,Queiroz Monteiro, R.,Verli, H.,Polikarpov, I. Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases. Biochim.Biophys.Acta 2009 1794 873 881 2NXA 17915249 Structure of Zn-dependent Metallo-Beta-Lactamase from Bacillus Cereus R121H, C221D Double Mutant 2006-11-17 2007-05-22 Gonzalez, J.M.,Medrano Martin, F.J.,Costello, A.L.,Tierney, D.L.,Vila, A.J. The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold. J.Mol.Biol. 2007 373 1141 1156 2NYP 17915249 Structure of beta-lactamase II from Bacillus cereus. R121H, C221D doble mutant with two zinc ions. 2006-11-21 2007-05-22 Gonzalez, J.M.,Medrano Martin, F.J.,Costello, A.L.,Tierney, D.L.,Vila, A.J. The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold. J.Mol.Biol. 2007 373 1141 1156 2NZE 17915249 Structure of beta-lactamase II from Bacillus cereus. R121H, C221S double mutant. Space group P3121. 2006-11-23 2007-05-29 Gonzalez, J.M.,Medrano Martin, F.J.,Costello, A.L.,Tierney, D.L.,Vila, A.J. The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold. J.Mol.Biol. 2007 373 1141 1156 2NZF 17915249 Structure of beta-lactamase II from Bacillus cereus. R121H, C221S double mutant. Space group C2. 2006-11-23 2007-05-29 Gonzalez, J.M.,Medrano Martin, F.J.,Costello, A.L.,Tierney, D.L.,Vila, A.J. The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold. J.Mol.Biol. 2007 373 1141 1156 2H5Y 16511325 Crystallographic structure of the Molybdate-Binding Protein of Xanthomonas citri at 1.7 Ang resolution bound to molybdate 2006-05-29 2007-06-05 Santacruz, C.P.,Balan, A.,Ferreira, L.C.,Barbosa, J.A.R.G. Crystallization, data collection and phasing of the molybdate-binding protein of the phytopathogen Xanthomonas axonopodis pv. citri Acta Crystallogr.,Sect.F 2006 62 289 291 2H5Z 16880547 Crystallographic structure of digestive lysozyme 1 from Musca domestica bound to chitotetraose at 1.92 A resolution 2006-05-29 2007-06-05 Marana, S.R.,Cancado, F.C.,Valerio, A.A.,Ferreira, C.,Terra, W.R.,Barbosa, J.A.R.G. Crystallization, data collection and phasing of two digestive lysozymes from Musca domestica Acta Crystallogr.,Sect.F 2006 62 750 752 2OK0 17512945 Fab ED10-DNA complex 2007-01-15 2007-06-12 Sanguineti, S.,Centeno Crowley, J.M.,Lodeiro Merlo, M.F.,Cerutti, M.L.,Wilson, I.A.,Goldbaum, F.A.,Stanfield, R.L.,de Prat-Gay, G. Specific recognition of a DNA immunogen by its elicited antibody J.Mol.Biol. 2007 370 183 195 2H8I 17157889 Crystal Structure of the Bothropstoxin-I complexed with polyethylene glycol 2006-06-07 2007-06-19 Murakami, M.T.,Vicotia, M.M.,Abrego, J.R.B.,Lourenzoni, M.R.,Cintra, A.C.O.,Arruda, E.Z.,Tomaz, M.A.,Melo, P.A.,Arni, R.K. Interfacial surface charge and free accessibility to the PLA2-active site-like region are essential requirements for the activity of Lys49 PLA2 homologues Toxicon 2007 49 378 387 2H8U Bucain, a cardiotoxin from the Malayan Krait Bungarus candidus 2006-06-08 2007-06-19 Murakami, M.T.,Kini, R.M.,Arni, R.K. Crystal Structure of Bucain To be Published 0 0 0 0 2O95 17559875 Crystal Structure of the Metal-Free Dimeric Human Mov34 MPN domain (residues 1-186) 2006-12-13 2007-07-17 Sanches, M.,Alves, B.S.C.,Zanchin, N.I.T.,Guimaraes, B.G. The Crystal Structure of the Human Mov34 MPN Domain Reveals a Metal-free Dimer J.Mol.Biol. 2007 370 846 855 2O96 17559875 Crystal Structure of the Metal-Free Dimeric Human Mov34 MPN domain (residues 1-177) 2006-12-13 2007-07-17 Sanches, M.,Alves, B.S.C.,Zanchin, N.I.T.,Guimaraes, B.G. The Crystal Structure of the Human Mov34 MPN Domain Reveals a Metal-free Dimer J.Mol.Biol. 2007 370 846 855 2IDZ 17588773 Crystal structure of wild type Enoyl-ACP(CoA) reductase from Mycobacterium tuberculosis in complex with NADH-INH 2006-09-15 2007-07-24 Dias, M.V.,Vasconcelos, I.B.,Prado, A.M.,Fadel, V.,Basso, L.A.,de Azevedo, W.F.,Santos, D.S. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. J.Struct.Biol. 2007 159 369 380 2IE0 17588773 Crystal Structure of Isoniazid-resistant I21V Enoyl-ACP(COA) Reductase Mutant Enzyme From MYCOBACTERIUM TUBERCULOSIS in Complex with NADH-INH 2006-09-15 2007-07-24 Dias, M.V.,Vasconcelos, I.B.,Prado, A.M.,Fadel, V.,Basso, L.A.,de Azevedo, W.F.,Santos, D.S. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. J.Struct.Biol. 2007 159 369 380 2IEB 17588773 Crystal Structure of Isoniazid-resistant S94A ENOYL-ACP(COA) Reductase Mutant Enzyme from MYCOBACTERIUM TUBERCULOSIS in Complex with NADH-INH 2006-09-18 2007-07-24 Dias, M.V.,Vasconcelos, I.B.,Prado, A.M.,Fadel, V.,Basso, L.A.,de Azevedo, W.F.,Santos, D.S. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. 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J.Struct.Biol. 2007 160 168 176 2OW4 17881248 Crystal structure of a lectin from Canavalia maritima seeds (ConM) in complex with man1-2man-OMe 2007-02-15 2007-10-23 Bezerra, G.A.,Oliveira, T.M.,Moreno, F.B.,de Souza, E.P.,da Rocha, B.A.,Benevides, R.G.,Delatorre, P.,de Azevedo, W.F.,Cavada, B.S. Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: New insights into the understanding of the structure-biological activity relationship in legume lectins. J.Struct.Biol. 2007 160 168 176 2P2K 17881248 Crystal structure of a lectin from Canavalia gladiata seeds (CGL) in complex with man1-4man-OMe 2007-03-07 2007-10-23 Bezerra, G.A.,Oliveira, T.M.,Moreno, F.B.,de Souza, E.P.,da Rocha, B.A.,Benevides, R.G.,Delatorre, P.,de Azevedo, W.F.,Cavada, B.S. Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: New insights into the understanding of the structure-biological activity relationship in legume lectins. J.Struct.Biol. 2007 160 168 176 2EF6 17881248 Canavalia gladiata lectin complexed with Man1-3Man-OMe 2007-02-21 2007-10-30 Bezerra, G.A.,Oliveira, T.M.,Moreno, F.B.M.B.,de Souza, E.P.,da Rocha, B.A.M.,Benevides, R.G.,Delatorre, P.,de Azevedo Jr., W.F.,Cavada, B.S. Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: New insights into the understanding of the structure-biological activity relationship in legume lectins J.Struct.Biol. 2007 160 168 176 2P37 17881248 Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-3man-OMe 2007-03-08 2007-11-06 Bezerra, G.A.,Oliveira, T.M.,Moreno, F.B.,de Souza, E.P.,da Rocha, B.A.,Benevides, R.G.,Delatorre, P.,de Azevedo, W.F.,Cavada, B.S. Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: New insights into the understanding of the structure-biological activity relationship in legume lectins. J.Struct.Biol. 2007 160 168 176 2PTZ 17822439 Crystal Structure of the T. brucei enolase complexed with phosphonoacetohydroxamate (PAH), His156-out conformation 2007-05-08 2007-11-20 Navarro, M.V.,Gomes Dias, S.M.,Mello, L.V.,da Silva Giotto, M.T.,Gavalda, S.,Blonski, C.,Garratt, R.C.,Rigden, D.J. Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics. Febs J. 2007 274 5077 5089 2P38 18001138 Crystal Structure of Pyrococcus Abyssi Protein Homologue of Saccharomyces Cerevisiae NIP7P 2007-03-08 2008-01-15 Coltri, P.P.,Guimaraes, B.G.,Granato, D.C.,Luz, J.S.,Teixeira, E.C.,Oliveira, C.C.,Zanchin, N.I. Structural Insights into the Interaction of the Nip7 PUA Domain with Polyuridine RNA Biochemistry 2007 46 14177 14187 2P34 17881248 Crystal structure of a lectin from Canavalia maritima seeds (CML) in complex with man1-4man-OMe 2007-03-08 2008-01-22 Bezerra, G.A.,Oliveira, T.M.,Moreno, F.B.M.B.,de Souza, E.P.,da Rocha, B.A.M.,Benevides, R.G.,Delatorre, P.,de Azevedo Jr., W.F.,Cavada, B.S. Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins. J.Struct.Biol. 2007 160 168 176 2OQD 18261474 Crystal Structure of BthTX-II 2007-01-31 2008-02-12 Correa, L.C.,Marchi-Salvador, D.P.,Cintra, A.C.,Sampaio, S.V.,Soares, A.M.,Fontes, M.R. Crystal structure of a myotoxic Asp49-phospholipase A(2) with low catalytic activity: Insights into Ca(2+)-independent catalytic mechanism. Biochim.Biophys.Acta 2008 1784 591 599 3B8A 18260108 Crystal structure of yeast hexokinase PI in complex with glucose 2007-10-31 2008-02-26 Kuser, P.,Cupri, F.,Bleicher, L.,Polikarpov, I. Crystal structure of yeast hexokinase PI in complex with glucose: A classical ""induced fit"" example revised. Proteins 2008 72 731 740 2EIG 18068379 Lotus tetragonolobus seed lectin (Isoform) 2007-03-13 2008-03-04 Moreno, F.B.M.B.,de Oliveira, T.M.,Martil, D.E.,Vicoti, M.M.,Bezerra, G.A.,Abrego, J.R.B.,Cavada, B.S.,Filgueira de Azevedo Jr., W. Identification of a new quaternary association for legume lectins J.Struct.Biol. 2008 161 133 143 2YRS Human hemoglobin D Los Angeles: crystal structure 2007-04-03 2008-03-11 Poy, C.D.,Moreno, F.,Bonini-Domingos, C.R.,Filgueira de Azevedo Jr., W.,Bonilla-Rodriguez, G.O. Human Hemoglobin D Los Angeles: crystal structure to be published 0 0 0 0 2PH4 18295812 Crystal structure of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venom 2007-04-10 2008-03-18 Murakami, M.T.,Kuch, U.,Betzel, C.,Mebs, D.,Arni, R.K. Crystal structure of a novel myotoxic Arg49 phospholipase A(2) homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: Insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus. Toxicon 2008 51 723 735 2PNZ 18353775 Crystal structure of the P. abyssi exosome RNase PH ring complexed with UDP and GMP 2007-04-25 2008-03-18 Navarro, M.V.A.S.,Oliveira, C.C.,Zanchin, N.I.,Guimaraes, B.G. Insights into the mechanism of progressive RNA degradation by the archaeal exosome. J.Biol.Chem. 2008 283 14120 14131 2PO0 18353775 Crystal structure of the P. abyssi exosome RNase PH ring complexed with ADP in double conformation 2007-04-25 2008-03-18 Navarro, M.V.A.S.,Oliveira, C.C.,Zanchin, N.I.,Guimaraes, B.G. Insights into the mechanism of progressive RNA degradation by the archaeal exosome. J.Biol.Chem. 2008 283 14120 14131 2PO1 18353775 Crystal structure of the P. abyssi exosome RNase PH ring complexed with a single stranded 10-mer poly(A) RNA 2007-04-25 2008-03-18 Navarro, M.V.A.S.,Oliveira, C.C.,Zanchin, N.I.,Guimaraes, B.G. Insights into the mechanism of progressive RNA degradation by the archaeal exosome. J.Biol.Chem. 2008 283 14120 14131 2PO2 18353775 Crystal structure of the P. abyssi exosome RNase PH ring complexed with CDP 2007-04-25 2008-03-18 Navarro, M.V.A.S.,Oliveira, C.C.,Zanchin, N.I.,Guimaraes, B.G. Insights into the mechanism of progressive RNA degradation by the archaeal exosome. J.Biol.Chem. 2008 283 14120 14131 2Q76 17916365 Mouse anti-hen egg white lysozyme antibody F10.6.6 Fab fragment 2007-06-06 2008-03-18 Acierno, J.P.,Braden, B.C.,Klinke, S.,Goldbaum, F.A.,Cauerhff, A. Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies. J.Mol.Biol. 2007 374 130 146 2Q76 17916365 Mouse anti-hen egg white lysozyme antibody F10.6.6 Fab fragment 2007-06-06 2008-03-18 Acierno, J.P.,Braden, B.C.,Klinke, S.,Goldbaum, F.A.,Cauerhff, A. Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies. J.Mol.Biol. 2007 374 130 146 2RC5 17958910 Refined structure of FNR from Leptospira interrogans 2007-09-19 2008-03-25 Nascimento, A.S.,Catalano-Dupuy, D.L.,Bernardes, A.,Neto, M.O.,Santos, M.A.,Ceccarelli, E.A.,Polikarpov, I. Crystal structures of Leptospira interrogans FAD-containing ferredoxin-NADP+ reductase and its complex with NADP+. Bmc Struct.Biol. 2007 7 69 69 2QOG 18275084 Crotoxin B, the basic PLA2 from Crotalus durissus terrificus. 2007-07-20 2008-04-01 Marchi-Salvador, D.P.,Correa, L.C.,Magro, A.J.,Oliveira, C.Z.,Soares, A.M.,Fontes, M.R. Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom. Proteins 2008 72 883 891 3C3N 18302934 Crystal structure of dihydroorotate dehydrogenase from Trypanosoma cruzi strain Y 2008-01-28 2008-04-29 Pinheiro, M.P.,Iulek, J.,Cristina Nonato, M. Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain Biochem.Biophys.Res.Commun. 2008 369 812 817 2Q2J 19401234 Crystal structure of PrTX-I, a PLA2 homolog from Bothrops pirajai 2007-05-28 2008-06-10 dos Santos, J.I.,Soares, A.M.,Fontes, M.R. Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site. J.Struct.Biol. 2009 167 106 116 3CUY 18596046 Crystal Structure of GumK mutant D157A 2008-04-17 2008-07-01 Barreras, M.,Salinas, S.R.,Abdian, P.L.,Kampel, M.A.,Ielpi, L. Structure and mechanism of GumK, a membrane-associated glucuronosyltransferase. J.Biol.Chem. 2008 283 25027 25035 3CV3 18596046 Crystal Structure of GumK mutant D157A in complex with UDP 2008-04-17 2008-07-01 Barreras, M.,Salinas, S.R.,Abdian, P.L.,Kampel, M.A.,Ielpi, L. Structure and mechanism of GumK, a membrane-associated glucuronosyltransferase. J.Biol.Chem. 2008 283 25027 25035 2ZBJ 18682294 Crystal structure of Dioclea rostrata lectin 2007-10-22 2008-08-19 de Oliveira, T.M.,Delatorre, P.,da Rocha, B.A.M.,de Souza, E.P.,Nascimento, K.S.,Bezerra, G.A.,Moura, T.R.,Benevides, R.G.,Bezerra, E.H.S.,Moreno, F.B.M.B.,Freire, V.N.,de Azevedo Jr., W.F.,Cavada, B.S. Crystal structure of Dioclea rostrata lectin: Insights into understanding the pH-dependent dimer-tetramer equilibrium and the structural basis for carbohydrate recognition in Diocleinae lectins J.Struct.Biol. 2008 164 177 182 2ZBJ 18682294 Crystal structure of Dioclea rostrata lectin 2007-10-22 2008-08-19 de Oliveira, T.M.,Delatorre, P.,da Rocha, B.A.M.,de Souza, E.P.,Nascimento, K.S.,Bezerra, G.A.,Moura, T.R.,Benevides, R.G.,Bezerra, E.H.S.,Moreno, F.B.M.B.,Freire, V.N.,de Azevedo Jr., W.F.,Cavada, B.S. Crystal structure of Dioclea rostrata lectin: Insights into understanding the pH-dependent dimer-tetramer equilibrium and the structural basis for carbohydrate recognition in Diocleinae lectins J.Struct.Biol. 2008 164 177 182 3C9X 18675276 Crystal structure of Trichoderma reesei aspartic proteinase 2008-02-19 2008-08-19 Nascimento, A.S.,Krauchenco, S.,Golubev, A.M.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A. J.Mol.Biol. 2008 382 763 778 3CQD 18762190 Structure of the tetrameric inhibited form of phosphofructokinase-2 from Escherichia coli 2008-04-02 2008-09-16 Cabrera, R.,Ambrosio, A.L.,Garratt, R.C.,Guixe, V.,Babul, J. Crystallographic structure of phosphofructokinase-2 from Escherichia coli in complex with two ATP molecules. Implications for substrate inhibition. J.Mol.Biol. 2008 383 588 602 2OK9 19616648 PrTX-I-BPB 2007-01-16 2008-09-23 Marchi-Salvador, D.P.,Fernandes, C.A.,Silveira, L.B.,Soares, A.M.,Fontes, M.R. Crystal structure of a phospholipase A(2) homolog complexed with p-bromophenacyl bromide reveals important structural changes associated with the inhibition of myotoxic activity. Biochim.Biophys.Acta 2009 1794 1583 1590 2REM Crystal Structure of oxidoreductase DsbA from Xylella fastidiosa 2007-09-26 2008-10-07 Rinaldi, F.C.,Guimaraes, B.G. Residues substitution in the active site of DSBA may compensate for the lack of the canonical motif CPHC To be Published 0 0 0 0 3BCQ Crystal structure of oxy-hemoglobin from Brycon cephalus 2007-11-13 2008-10-07 Poy, C.D.,Leopoldino, A.M.,Rahal, P.,de Azevedo, W.F.,Rodriguez, G.O.B.,Murakami, M.T. Crystal structure of oxy-hemoglobin from Brycon cephalus To be Published 0 0 0 0 3EMY 18675276 Crystal structure of Trichoderma reesei aspartic proteinase complexed with pepstatin A 2008-09-25 2008-10-07 Nascimento, A.S.,Krauchenco, S.,Golubev, A.M.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A. J.Mol.Biol. 2008 382 763 778 3DMT Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in complex with the irreversible iodoacetate inhibitor 2008-07-01 2008-10-21 Guido, R.V.C.,Balliano, T.L.,Andricopulo, A.D.,Oliva, G. Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate. Letters in drug design & disco 2009 6 210 214 3DSL 18831982 The Three-dimensional Structure of Bothropasin, the Main Hemorrhagic Factor from Bothrops jararaca venom. 2008-07-13 2008-10-21 Muniz, J.R.,Ambrosio, A.L.,Selistre-de-Araujo, H.S.,Cominetti, M.R.,Moura-da-Silva, A.M.,Oliva, G.,Garratt, R.C.,Souza, D.H. The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: Insights for a new classification of snake venom metalloprotease subgroups. Toxicon 2008 52 807 816 3D4M 18992757 Glutaredoxin 2 oxidized structure 2008-05-14 2008-10-28 Discola, K.F.,de Oliveira, M.A.,Rosa Cussiol, J.R.,Monteiro, G.,Barcena, J.A.,Porras, P.,Padilla, C.A.,Guimaraes, B.G.,Netto, L.E. Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae. J.Mol.Biol. 2009 385 889 901 3D5J 18992757 Structure of yeast Grx2-C30S mutant with glutathionyl mixed disulfide 2008-05-16 2008-10-28 Discola, K.F.,de Oliveira, M.A.,Rosa Cussiol, J.R.,Monteiro, G.,Barcena, J.A.,Porras, P.,Padilla, C.A.,Guimaraes, B.G.,Netto, L.E. Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae. J.Mol.Biol. 2009 385 889 901 3BAF Crystal structure of shikimate kinase from Mycobacterium tuberculosis in complex with AMP-PNP 2007-11-07 2008-11-11 Faim, L.M.,Dias, M.V.B.,Vasconcelos, I.G.,Basso, L.A.,Santos, D.S.,Azevedo, W.F.,Ruggiero, N.J. Crystal Structure for shikimate kinase from Mycobacterium tuberculosis in complex with AMP-PNP To be Published 0 0 0 0 3ER0 Crystal structure of the full length eIF5A from Saccharomyces cerevisiae 2008-10-01 2008-12-02 Sanches, M.,Dias, C.A.O.,Aponi, L.H.,Valentini, S.R.,Guimaraes, B. Crystal structure of the full length eIF5A from Saccharomyces cerevisiae To be Published 0 0 0 0 3CB7 The crystallographic structure of the digestive lysozyme 2 from Musca domestica at 1.9 Ang. 2008-02-21 2009-02-24 Marana, S.R.,Cancado, F.C.,Valerio, A.A.,Ferreira, C.,Terra, W.R.,Barbosa, J.A.R.G. The crystallographic structure of the digestive lysozyme 2 from Musca domestica at 1.9 Ang. To be Published 0 0 0 0 3FNQ 20057051 Crystal structure of schistosoma purine nucleoside phosphorylase in complex with hypoxanthine 2008-12-26 2009-02-24 Pereira, H.M.,Rezende, M.M.,Castilho, M.S.,Oliva, G.,Garratt, R.C. Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni. Acta Crystallogr.,Sect.D 2010 66 73 79 3GLA 16682772 Crystal Structure of the hspA from Xanthomonas axonopodis 2009-03-11 2009-03-24 Hilario, E.,Teixeira, E.C.,Pedroso, G.A.,Bertolini, M.C.,Medrano, F.J. Crystallization and preliminary X-ray diffraction analysis of XAC1151, a small heat-shock protein from Xanthomonas axonopodis pv. citri belonging to the alpha-crystallin family Acta Crystallogr.,Sect.F 2006 62 446 448 3GLA 16682772 Crystal Structure of the hspA from Xanthomonas axonopodis 2009-03-11 2009-03-24 Hilario, E.,Teixeira, E.C.,Pedroso, G.A.,Bertolini, M.C.,Medrano, F.J. Crystallization and preliminary X-ray diffraction analysis of XAC1151, a small heat-shock protein from Xanthomonas axonopodis pv. citri belonging to the alpha-crystallin family Acta Crystallogr.,Sect.F 2006 62 446 448 3CXI 19401234 Structure of BthTX-I complexed with alpha-tocopherol 2008-04-24 2009-05-05 dos Santos, J.I.,Soares, A.M.,Fontes, M.R. Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site. J.Struct.Biol. 2009 167 106 116 3CYL 19401234 Crystal structure of Piratoxin I (a myotoxic Lys49-PLA2) complexed with alpha-tocopherol 2008-04-25 2009-05-05 dos Santos, J.I.,Soares, A.M.,Fontes, M.R. Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site. J.Struct.Biol. 2009 167 106 116 3GZG Crystal structure of the Xanthomonas axonopodis pv. citri molybdate-binding protein (ModA) mutant (K127S) 2009-04-07 2009-05-12 Santacruz-Perez, C.,Pegos, V.R.,Balan, A.,Barbosa, J.A.R.G. Crystal structure of the Xanthomonas axonopodis pv. citri molybdate-binding protein (ModA) mutant (K127S) To be Published 0 0 0 0 3HZD 20371382 Crystal structure of bothropstoxin-I (BthTX-I), a PLA2 homologue from Bothrops jararacussu venom 2009-06-23 2009-07-07 Fernandes, C.A.,Marchi-Salvador, D.P.,Salvador, G.M.,Silva, M.C.,Costa, T.R.,Soares, A.M.,Fontes, M.R. Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s. J.Struct.Biol. 2010 171 31 43 3D1V 18790691 Crystal structure of human PNP complexed with 2-mercapto(3H) quinazolinone 2008-05-06 2009-07-14 Timmers, L.F.,Caceres, R.A.,Vivan, A.L.,Gava, L.M.,Dias, R.,Ducati, R.G.,Basso, L.A.,Santos, D.S.,de Azevedo, W.F. Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function Arch.Biochem.Biophys. 2008 479 28 38 3E9Z Crystal structure of purine nucleoside phosphorylase from Schistosoma mansoni in complex with 6-chloroguanine 2008-08-24 2009-09-01 Pereira, H.M.,Rezende, M.M.,Oliva, G.,Garratt, R.C. Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase (SmPNP) in complex with adenine, 8-aminoguanine, 8-azaguanine and 6-chloroguanine. To be Published 0 0 0 0 3GBO 19706302 Crystal structure of BmooMPalpha-I, a non-hemorrhagic metalloproteinase isolated from Bothrops moojeni snake venom 2009-02-20 2009-09-22 Akao, P.K.,Tonoli, C.C.,Navarro, M.S.,Cintra, A.C.,Neto, J.R.,Arni, R.K.,Murakami, M.T. Structural studies of BmooMPalpha-I, a non-hemorrhagic metalloproteinase from Bothrops moojeni venom. Toxicon 2010 55 361 368 3I9P Crystal structure of human transthyretin - wild type 2009-07-12 2009-10-20 Lima, L.M.T.R.,Foguel, D. Crystal structure of human transthyretin - wild type To be Published 0 0 0 0 3IQ3 20371382 Crystal Structure of Bothropstoxin-I complexed with polietilene glicol 4000 - crystallized at 283 K 2009-08-19 2009-10-27 Fernandes, C.A.,Marchi-Salvador, D.P.,Salvador, G.M.,Silva, M.C.,Costa, T.R.,Soares, A.M.,Fontes, M.R. Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s. J.Struct.Biol. 2010 171 31 43 3FAZ 20057051 Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase in complex with inosine 2008-11-18 2009-11-24 Pereira, H.M.,Rezende, M.M.,Castilho, M.S.,Oliva, G.,Garratt, R.C. Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni. Acta Crystallogr.,Sect.D 2010 66 73 79 3FB1 21169694 Crystal Structure of Purine Nucleoside Phosphorylase in Complex with Ribose-1-Phosphate 2008-11-18 2009-11-24 D'Muniz Pereira, H.,Oliva, G.,Garratt, R.C. Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate. J.Synchrotron Radiat. 2011 18 62 65 3IJF 20035876 Crystal structure of cytidine deaminase from Mycobacterium tuberculosis 2009-08-04 2010-03-02 Sanchez-Quitian, Z.A.,Schneider, C.Z.,Ducati, R.G.,de Azevedo, W.F.,Bloch, C.,Basso, L.A.,Santos, D.S. Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase. J.Struct.Biol. 2010 169 413 423 3IEX 20129792 Schistosoma Purine nucleoside phosphorylase in complex with guanosine 2009-07-23 2010-03-16 Castilho, M.S.,Postigo, M.P.,Pereira, H.M.,Oliva, G.,Andricopulo, A.D. Structural basis for selective inhibition of purine nucleoside phosphorylase from Schistosoma mansoni: kinetic and structural studies Bioorg.Med.Chem. 2010 18 1421 1427 3GY2 20356563 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC 2009-04-03 2010-03-23 Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A. Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol. 2010 46 502 511 3GY3 20356563 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC 2009-04-03 2010-03-23 Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A. Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol. 2010 46 502 511 3GY5 20356563 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC 2009-04-03 2010-03-23 Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A. Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol. 2010 46 502 511 3GY6 20356563 A comparative study on the inhibition of bovine beta-trypsin by the bis-benzamidines diminazene and pentamidine 2009-04-03 2010-03-23 Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A. Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol. 2010 46 502 511 3GY8 20356563 A comparative study on the inhibition of bovine beta-trypsin by bis-benzamidines diminazene and pentamidine by X-ray crystallography and ITC 2009-04-03 2010-03-23 Perilo, C.S.,Pereira, M.T.,Santoro, M.M.,Nagem, R.A. Structural binding evidence of the trypanocidal drugs Berenil and Pentacarinate active principles to a serine protease model. Int.J.Biol.Macromol. 2010 46 502 511 3KGT 20211733 V30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.5 2009-10-29 2010-03-23 Trivella, D.B.,Bleicher, L.,Palmieri, L.C.,Wiggers, H.J.,Montanari, C.A.,Kelly, J.W.,Lima, L.M.,Foguel, D.,Polikarpov, I. Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J.Struct.Biol. 2010 170 522 531 3ITJ 20235561 Crystal structure of Saccharomyces cerevisiae thioredoxin reductase 1 (Trr1) 2009-08-28 2010-03-31 Oliveira, M.A.,Discola, K.F.,Alves, S.V.,Medrano, F.J.,Guimaraes, B.G.,Netto, L.E. Insights into the specificity of thioredoxin reductase-thioredoxin interactions. A structural and functional investigation of the yeast thioredoxin system. Biochemistry 2010 49 3317 3326 3A0K 21277932 Crystal structure of an antiflamatory legume lectin from Cymbosema roseum seeds 2009-03-20 2010-04-07 Rocha, B.A.,Delatorre, P.,Oliveira, T.M.,Benevides, R.G.,Pires, A.F.,Sousa, A.A.,Souza, L.A.,Ana Maria, S.A.,Debray, H.,de Azevedo, W.F.,Sampaio, A.H.,Cavada, B.S. Structural basis for both pro- and anti-inflammatory response induced by mannose-specific legume lectin from Cymbosema roseum Biochimie 2011 0 0 0 3GZ3 Leishmania major Dihydroorotate Dehydrogenase in complex with orotate 2009-04-06 2010-04-28 Cordeiro, A.T.,Feliciano, P.R.,Nonato, M.C. 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The structure of human carbonmonoxyhemoglobin complex to IHP at 2.0 Angstrons resolution To be Published 0 0 0 0 3I3H Crystal structure of Bothropstoxin-I crystallized at 291K 2009-06-30 2010-08-11 Salvador, G.H.M.,Marchi-Salvador, D.P.,Soares, A.M.,Fontes, M.R.M. Structural Studies with a BthTX-I a Lys49 PLA2 from Bothrops jararacussu Snake Venom Crystallized at Different Temperatures To be Published 0 0 0 0 3ILN 21619042 X-ray structure of the laminarinase from Rhodothermus marinus 2009-08-07 2010-08-18 Bleicher, L.,Prates, E.T.,Gomes, T.C.,Silveira, R.L.,Nascimento, A.S.,Rojas, A.L.,Golubev, A.,Martinez, L.,Skaf, M.S.,Polikarpov, I. Molecular basis of the thermostability and thermophilicity of laminarinases: X-ray structure of the hyperthermostable laminarinase from Rhodothermus marinus and molecular dynamics simulations. J.Phys.Chem.B 2011 115 7940 7949 3KNR 22729148 Bacillus cereus metallo-beta-lactamase Cys221Asp mutant, 1 mM Zn(II) 2009-11-12 2010-11-24 Gonzalez, J.M.,Meini, M.R.,Tomatis, P.E.,Medrano Martin, F.J.,Cricco, J.A.,Vila, A.J. Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions. Nat.Chem.Biol. 2012 8 698 700 3KNS 22729148 Bacillus cereus metallo-beta-lactamase Cys221Asp mutant, 20 mM Zn(II) 2009-11-12 2010-11-24 Gonzalez, J.M.,Meini, M.R.,Tomatis, P.E.,Medrano Martin, F.J.,Cricco, J.A.,Vila, A.J. Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions. Nat.Chem.Biol. 2012 8 698 700 3JU9 21530490 Crystal structure of a lectin from Canavalia brasiliensis seed (ConBr) complexed with alpha-aminobutyric acid 2009-09-14 2010-12-08 Bezerra, E.H.,Rocha, B.A.,Nagano, C.S.,Bezerra, G.A.,Moura, T.R.,Bezerra, M.J.,Benevides, R.G.,Sampaio, A.H.,Assreuy, A.M.,Delatorre, P.,Cavada, B.S. Structural analysis of ConBr reveals molecular correlation between the carbohydrate recognition domain and endothelial NO synthase activation. Biochem.Biophys.Res.Commun. 2011 408 566 570 3IOM 20570524 Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine 2009-08-14 2011-01-12 Ducati, R.G.,Basso, L.A.,Santos, D.S.,de Azevedo, W.F. Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Bioorg.Med.Chem. 2010 18 4769 4774 3INY 19932753 Crystal structure of human purine nucleoside phosphorylase in complex with 7-deazaguanine 2009-08-13 2011-01-19 Caceres, R.A.,Timmers, L.F.,Pauli, I.,Gava, L.M.,Ducati, R.G.,Basso, L.A.,Santos, D.S.,de Azevedo, W.F. Crystal structure and molecular dynamics studies of human purine nucleoside phosphorylase complexed with 7-deazaguanine. J.Struct.Biol. 2010 169 379 388 3GT6 21315085 Crystal Structure of the hspA from Xanthomonas axonopodis 2009-03-27 2011-02-16 Hilario, E.,Martin, F.J.,Bertolini, M.C.,Fan, L. Crystal structures of Xanthomonas small heat shock protein provide a structural basis for an active molecular chaperone oligomer. J.Mol.Biol. 2011 408 74 86 3GUF 21315085 Crystal Structure of the hspA from Xanthomonas axonopodis 2009-03-29 2011-02-16 Hilario, E.,Martin, F.J.,Bertolini, M.C.,Fan, L. Crystal structures of Xanthomonas small heat shock protein provide a structural basis for an active molecular chaperone oligomer. J.Mol.Biol. 2011 408 74 86 3MHU 20965617 Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Nitroorotic acid 2010-04-08 2011-02-23 Cheleski, J.,Rocha, J.R.,Pinheiro, M.P.,Wiggers, H.J.,da Silva, A.B.,Nonato, M.C.,Montanari, C.A. Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem. 2010 45 5899 5909 3MJY 20965617 Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid 2010-04-13 2011-02-23 Cheleski, J.,Rocha, J.R.,Pinheiro, M.P.,Wiggers, H.J.,da Silva, A.B.,Nonato, M.C.,Montanari, C.A. Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem. 2010 45 5899 5909 3MLM 21108987 Crystal structure of Bn IV in complex with myristic acid: A Lys49 myotoxic phospholipase A2 from Bothrops neuwiedi venom 2010-04-17 2011-05-18 Delatorre, P.,Rocha, B.A.,Santi-Gadelha, T.,Gadelha, C.A.,Toyama, M.H.,Cavada, B.S. Crystal structure of Bn IV in complex with myristic acid: a Lys49 myotoxic phospholipase A2 from Bothrops neuwiedi venom. Biochimie 2011 93 513 518 3RZ9 21806995 Mouse importin alpha-Ku80 NLS peptide complex 2011-05-11 2011-08-03 Takeda, A.A.,de Barros, A.C.,Chang, C.W.,Kobe, B.,Fontes, M.R. 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Protein Sci. 2012 21 964 976 3USQ 22128147 Structure of D159S/Y194F glycogenin mutant truncated at residue 270 2011-11-23 2011-12-14 Issoglio, F.M.,Carrizo, M.E.,Romero, J.M.,Curtino, J.A. Mechanisms of monomeric and dimeric glycogenin autoglucosylation. J.Biol.Chem. 2012 287 1955 1961 3USR 22128147 Structure of Y194F glycogenin mutant truncated at residue 270 2011-11-23 2011-12-14 Issoglio, F.M.,Carrizo, M.E.,Romero, J.M.,Curtino, J.A. Mechanisms of monomeric and dimeric glycogenin autoglucosylation. J.Biol.Chem. 2012 287 1955 1961 3V8Y 22226635 Structure of apo-glycogenin truncated at residue 270 2011-12-23 2012-01-25 Carrizo, M.E.,Romero, J.M.,Issoglio, F.M.,Curtino, J.A. Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation. Febs Lett. 2012 586 254 257 3V8Z 22226635 Structure of apo-glycogenin truncated at residue 270 complexed with UDP 2011-12-23 2012-01-25 Carrizo, M.E.,Romero, J.M.,Issoglio, F.M.,Curtino, J.A. 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Insect Biochem.Mol.Biol. 2012 42 655 664 3AX4 23353644 Three-dimensional structure of lectin from Dioclea violacea and comparative vasorelaxant effects with Dioclea rostrata 2011-03-29 2012-04-04 Bezerra, M.J.B.,Rodrigues, N.V.F.C.,Pires, A.F.,Bezerra, G.A.,Nobre, C.B.,Alencar, K.L.L.,Soares, P.M.G.,Nascimento, K.S.,Nagano, C.S.,Martins, J.L.,Gruber, K.,Sampaio, A.H.,Delatorre, P.,Rocha, B.A.M.,Assreuy, A.M.S.,Cavada, B.S. Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin Int.J.Biochem.Cell Biol. 2013 45 807 815 3TQ0 22542640 Crystal structure of Leishmania major dihydroorotate dehydrogenase in complex with fumarate 2011-09-08 2012-05-16 Cordeiro, A.T.,Feliciano, P.R.,Pinheiro, M.P.,Nonato, M.C. Crystal structure of dihydroorotate dehydrogenase from Leishmania major. Biochimie 2012 94 1739 1748 3SCZ Combining crystallographic, thermodynamic, and molecular dynamics studies of Mycobacterium tuberculosis purine nucleoside phosphorylase 2011-06-08 2012-06-20 de Azevedo Jr., W.F. Combining crystallographic, thermodynamic, and molecular dynamics studies of Mycobacterium tuberculosis purine nucleoside phosphorylase To be Published 0 0 0 0 3SUL 23902259 Crystal structure of cerato-platanin 3 from M. perniciosa (MpCP3) 2011-07-11 2012-07-11 de O Barsottini, M.R.,de Oliveira, J.F.,Adamoski, D.,Teixeira, P.J.,do Prado, P.F.,Tiezzi, H.O.,Sforca, M.L.,Cassago, A.,Portugal, R.V.,de Oliveira, P.S.,de M Zeri, A.C.,Dias, S.M.,Pereira, G.A.,Ambrosio, A.L. Functional diversification of cerato-platanins in Moniliophthora perniciosa as seen by differential expression and protein function specialization. Mol. 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Biochimie 2013 95 1697 1703 3T0R Crystal Structure of MjTX-I, a myotoxic Lys49-phospholipase A2 from Bothrops moojeni 2011-07-20 2012-08-01 Salvador, G.H.M.,Marchi-Salvador, D.P.,Fontes, M.R.M. Crystal Structure of MjTX-I, a myotoxic Lys49-phospholipase A2 from Bothrops moojeni To be Published 0 0 0 0 3SBC 22985967 Crystal structure of Saccharomyces cerevisiae TSA1C47S mutant protein 2011-06-03 2012-08-08 Tairum, C.A.,de Oliveira, M.A.,Horta, B.B.,Zara, F.J.,Netto, L.E. Disulfide biochemistry in 2-cys peroxiredoxin: requirement of Glu50 and Arg146 for the reduction of yeast Tsa1 by thioredoxin. J.Mol.Biol. 2012 424 28 41 3RU4 Crystal structure of the Bowman-Birk serine protease inhibitor BTCI in complex with trypsin and chymotrypsin 2011-05-04 2012-08-29 Esteves, G.F.,Teles, R.C.L.,Cavalcante, N.S.,Neves, D.,Ventura, M.M.,Barbosa, J.A.R.G.,Freitas, S.M. Crystal structure of the Bowman-Birk serine protease inhibitor BTCI in complex with trypsin and chymotrypsin To be Published 0 0 0 0 3TRO Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant D171A 2011-09-09 2012-09-12 de Souza, A.L.,Pinheiro, M.P.,Nonato, M.C. Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant D171A To be Published 0 0 0 0 3U4X 22554687 Crystal structure of a lectin from Camptosema pedicellatum seeds in complex with 5-bromo-4-chloro-3-indolyl-alpha-D-mannose 2011-10-10 2012-09-12 Souza Teixeira, C.,Colares da Silva, H.,Rocha de Moura, T.,Pereira-Junior, F.N.,Santiago do Nascimento, K.,Shiniti Nagano, C.,Holanda Sampaio, A.,Delatorre, P.,Matias Rocha, B.A.,Sousa Cavada, B. Crystal structure of the lectin of Camptosema pedicellatum: implications of a conservative substitution at the hydrophobic subsite. J.Biochem. 2012 152 87 98 4H55 Crystal structure of Canavalia brasiliensis seed lectin (ConBr) in complex with beta-d-ribofuranose 2012-09-18 2012-10-31 Salviano, E.,Rocha, B.A.M.,Cavada, B.S.,Delatorre, P.,Santi-Gadelha, T.,Gadelha, C.A.A.,Silva-Filho, J.C.,Nobrega, R.B.,Farias, D.L. Crystal structure of Canavalia brasiliensis seed lectin (ConBr) in complex with beta-d-ribofuranose TO BE PUBLISHED 0 0 0 0 4I30 Crystal structure of Canavalia maritima seeds lectin (ConM) co-crystalized with gamma-aminobutyric acid (GABA) and soaked with adenine 2012-11-23 2012-12-12 Delatorre, P.,Silva-Filho, J.C.,Nobrega, R.B.,Gadelha, C.A.A.,Cavada, B.S.,Rocha, B.A.M.,Santi-Gadelha, T.,Teixeira, C.S. Crystal structure of Canavalia maritima seeds lectin (ConM) co-crystalized with gamma-aminobutyric acid (GABA) and soaked with adenine To be Published 0 0 0 0 3W3B Crystal structure of wild-type human transthyretin 2012-12-19 2013-01-30 Lima, L.M.T.R. Crystal structure of wild-type human transthyretin TO BE PUBLISHED 0 0 0 0 4IK6 Crystal structure of human transthyretin in complex with lumiracoxib 2012-12-25 2013-01-30 Lima, L.M.T.R. Crystal structure of human transthyretin in complex with lumiracoxib To be Published 0 0 0 0 4IK7 Crystal structure of human transthyretin in complex with indomethacin 2012-12-25 2013-01-30 Lima, L.M.T.R. Crystal structure of human transthyretin in complex with indomethacin To be Published 0 0 0 0 4IKJ Crystal structure of wild-type human transthyretin in complex with sulindac 2012-12-26 2013-01-30 Lima, L.M.T.R. Crystal structure of wild-type human transthyretin in complex with sulindac To be Published 0 0 0 0 4IKK Crystal structure of wild-type human transthyretin in complex with sulindac 2012-12-26 2013-01-30 Lima, L.M.T.R. Crystal structure of wild-type human transthyretin in complex with sulindac To be Published 0 0 0 0 4DPN Crystal Structure of ConM Complexed with Resveratrol 2012-02-13 2013-03-06 Freire, V.N.,Gottfried, C.,Rocha, B.A.M.,Cavada, B.S.,Delatorre, P.,Santi-Gadelha, T.,A Gadelha, C.A.,Batista, G.N.,N brega, R.B.,Silva-Filho, J.C. Crystal Structure of ConM Complexed with Resveratrol To be Published 0 0 0 0 4FOK 23507310 1.8 A Crystal structure of the FimX EAL domain in complex with c-diGMP 2012-06-20 2013-03-27 Guzzo, C.R.,Dunger, G.,Salinas, R.K.,Farah, C.S. Structure of the PilZ-FimXEAL-c-di-GMP Complex Responsible for the Regulation of Bacterial Type IV Pilus Biogenesis. J.Mol.Biol. 2013 425 2174 2197 4EWW 23692694 Human Insulin 2012-04-28 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EWZ 23692694 Human Insulin 2012-04-29 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EX0 23692694 Human Insulin 2012-04-29 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EX1 23692694 Human Insulin 2012-04-29 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EXX 23692694 Human Insulin 2012-05-01 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EY1 23692694 Human Insulin 2012-05-01 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EY9 23692694 Human Insulin 2012-05-01 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EYD 23692694 Human Insulin 2012-05-01 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm 2013 85 1112 1121 4EYN 23692694 Human Insulin 2012-05-01 2013-05-01 Favero-Retto, M.P.,Palmieri, L.C.,Souza, T.A.,Almeida, F.C.,Lima, L.M. Structural meta-analysis of regular human insulin in pharmaceutical formulations. 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The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1. Proteins 2020 88 106 112 6E05 30289406 Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in sulfate precipitant) 2018-07-06 2018-10-17 Thompson, A.P.,Wegener, K.L.,Booker, G.W.,Polyak, S.W.,Bruning, J.B. Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. Acta Crystallogr D Struct Biol 2018 74 965 972 6E06 30289406 Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in citrate precipitant) 2018-07-06 2018-10-17 Thompson, A.P.,Wegener, K.L.,Booker, G.W.,Polyak, S.W.,Bruning, J.B. Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. 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Acs Infect Dis. 2020 6 2192 2201 6VS8 32603583 Mycobacterium tuberculosis dihydrofolate reductase in complex with ethyl 2-methyl thiazole-4-carboxylate(fragment 3) 2020-02-10 2020-07-15 Ribeiro, J.A.,Hammer, A.,Libreros-Zuniga, G.A.,Chavez-Pacheco, S.M.,Tyrakis, P.,de Oliveira, G.S.,Kirkman, T.,El Bakali, J.,Rocco, S.A.,Sforca, M.L.,Parise-Filho, R.,Coyne, A.G.,Blundell, T.L.,Abell, C.,Dias, M.V.B. Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis. 2020 6 2192 2201 3IX2 22033138 CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACYCLOVIR 2009-09-03 2021-07-21 Caceres, R.A.,Timmers, L.F.,Ducati, R.G.,da Silva, D.O.,Basso, L.A.,de Azevedo Jr., W.F.,Santos, D.S. Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir. Biochimie 2012 94 155 165 7MK0 34981759 Trypanosoma cruzi Nucleoside Diphosphate Kinase 1 form a quinary multihexameric structure 2021-04-21 2022-01-12 Gomez Barroso, J.A.,Miranda, M.R.,Pereira, C.A.,Garratt, R.C.,Aguilar, C.F. X-ray diffraction and in vivo studies reveal the quinary structure of Trypanosoma cruzi nucleoside diphosphate kinase 1: a novel helical oligomer structure. Acta Crystallogr D Struct Biol 2022 78 30 42 7MX6 Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol 2021-05-18 2022-05-18 Pinheiro, M.P.,Hunter, W.N.,Cardoso, I.A.,Nonato, M.C. Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol To be Published 0 0 0 0 7MYD Leishmania major dihydroorotate dehydrogenase in complex with 5-amino-2-(1H-pyrrol-1-yl)benzonitrile 2021-05-20 2022-05-25 Pinheiro, M.P.,Cardoso, I.A.,Hunter, W.N.,Nonato, M.C. Leishmania major dihydroorotate dehydrogenase in complex with 5-amino-2-(1H-pyrrol-1-yl)benzonitrile To Be Published 0 0 0 0 7ROX 36273763 BthTX-I complexed with inhibitor MMV 2021-08-02 2022-11-09 Borges, R.J.,Cardoso, F.F.,de Carvalho, C.,de Marino, I.,Pereira, P.S.,Soares, A.M.,Dal-Pai-Silva, M.,Uson, I.,Fontes, M.R.M. Structural and functional studies of a snake venom phospholipase A 2 -like protein complexed to an inhibitor from Tabernaemontana catharinensis. Biochimie 2023 206 105 115