PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 1TQ8 Crystal Structure of protein Rv1636 from Mycobacterium tuberculosis H37Rv 2004-06-16 2004-06-29 RAJASHANKAR, K.R.,KNIEWEL, R.,SOLORZANO, V.,LIMA, C.D. Crystal Structure of hypothetical protein Rv1636 from Mycobacterium tuberculosis H37Rv To be Published 0 0 0 0 1U02 16815921 Crystal structure of trehalose-6-phosphate phosphatase related protein 2004-07-12 2004-07-20 Rao, K.N.,Kumaran, D.,Seetharaman, J.,Bonanno, J.B.,Burley, S.K.,Swaminathan, S. Crystal structure of trehalose-6-phosphate phosphatase-related protein: biochemical and biological implications. Protein Sci. 2006 15 1735 1744 1XD7 Crystal structure of a putative DNA binding protein 2004-09-04 2004-09-21 Agarwal, R.,Swaminathan, S. Crystal structure of a putative DNA binding protein To be Published 0 0 0 0 1XM5 16511207 Crystal structure of metal-dependent hydrolase ybeY from E. coli, Pfam UPF0054 2004-10-01 2004-10-12 Zhan, C.,Fedorov, E.V.,Shi, W.,Ramagopal, U.A.,Thirumuruhan, R.,Manjasetty, B.A.,Almo, S.C.,Fiser, A.,Chance, M.R.,Fedorov, A.A. The ybeY protein from Escherichia coli is a metalloprotein. Acta Crystallogr.,Sect.F 2005 61 959 963 1XM5 16511207 Crystal structure of metal-dependent hydrolase ybeY from E. coli, Pfam UPF0054 2004-10-01 2004-10-12 Zhan, C.,Fedorov, E.V.,Shi, W.,Ramagopal, U.A.,Thirumuruhan, R.,Manjasetty, B.A.,Almo, S.C.,Fiser, A.,Chance, M.R.,Fedorov, A.A. The ybeY protein from Escherichia coli is a metalloprotein. Acta Crystallogr.,Sect.F 2005 61 959 963 1TWY Crystal structure of an ABC-type phosphate transport receptor from Vibrio cholerae 2004-07-01 2004-12-21 Ramagopal, U.A.,Patskovsky, Y.,Almo, S.C. Crystal structure of hypothetical ABC-type phosphate transporter To be Published 0 0 0 0 1Y8C Crystal structure of a S-adenosylmethionine-dependent methyltransferase from Clostridium acetobutylicum ATCC 824 2004-12-11 2004-12-28 Rajashankar, K.R.,Kniewel, R.,Lee, K.,Lima, C.D. Crystal structure of a S-adenosylmethionine-dependent methyltransferase from Clostridium acetobutylicum ATCC 824 To be Published 0 0 0 0 1Y7E The Crystal Structure of Aminopeptidase I from Borrelia burgdorferi B31 2004-12-08 2005-01-04 Min, T.,Gorman, J.,Shapiro, L. The crystal structure of aminopeptidase I (yscI) from Borrelia burgdorferi To be Published 0 0 0 0 1YBF Crystal structure of AMP nucleosidase from Bacteroides thetaiotaomicron VPI-5482 2004-12-20 2005-01-04 Krishnamurthy, N.R.,Swaminathan, S. Crystal structure of AMP nucleosidase from Bacteroides thetaiotaomicron To be published 0 0 0 0 1YCO Crystal structure of a branched-chain phosphotransacylase from Enterococcus faecalis V583 2004-12-22 2005-01-18 Rajashankar, K.R.,Kniewel, R.,Lee, K.,Lima, C.D. Crystal structure of a branched-chain phosphotransacylase from Enterococcus faecalis V583 To be Published 0 0 0 0 1YDF Crystal structure of a HAD-like phosphatase from Streptococcus pneumoniae 2004-12-23 2005-01-18 Seetharaman, J.,Swaminathan, S. Crystal Structure of a Hypothetical protein, hydrolase haloacid dehalogenase-like family To be Published 0 0 0 0 1YIR Crystal Structure of a Nicotinate Phosphoribosyltransferase 2005-01-12 2005-02-01 Seetharaman, J.,Swaminathan, S. Crystal Structure of a Nicotinate Phosphoribosyltransferase To be Published 0 0 0 0 1YMY Crystal Structure of the N-Acetylglucosamine-6-phosphate deacetylase from Escherichia coli K12 2005-01-21 2005-02-01 Fedorov, A.A.,Fedorov, E.V.,Xiang, D.F.,Raushel, F.M.,Almo, S.C. Crystal structure of the N-acetylglucosamine-6-phosphate deacetylase from Escherichia Coli To be Published 0 0 0 0 1YBD Crystal structure analysis of uridylate kinase from Neisseria meningitidis 2004-12-20 2005-02-15 Kumaran, D.,Swaminathan, S. Crystal structure analysis of uridylate kinase from Neisseria meningitidis To be Published 0 0 0 0 1YMM 15821740 TCR/HLA-DR2b/MBP-peptide complex 2005-01-21 2005-05-03 Hahn, M.,Nicholson, M.J.,Pyrdol, J.,Wucherpfennig, K.W. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. NAT.IMMUNOL. 2005 6 490 496 1ZA2 15951418 Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of CTP, carbamoyl phosphate at 2.50 A resolution 2005-04-05 2005-06-07 Wang, J.,Stieglitz, K.A.,Cardia, J.P.,Kantrowitz, E.R. Structural basis for ordered substrate binding and cooperativity in aspartate transcarbamoylase Proc.Natl.Acad.Sci.Usa 2005 102 8881 8886 1ZTP 16511166 X-ray structure of gene product from homo sapiens Hs.433573 2005-05-27 2005-06-14 Bitto, E.,Bingman, C.A.,Robinson, H.,Allard, S.T.,Wesenberg, G.E.,Phillips, G.N. The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. Acta Crystallogr.,Sect.F 2005 61 812 817 1ZWL 16322580 Structure of WrbA from Pseudomonas aeruginosa in complex with FMN 2005-06-03 2005-06-14 Gorman, J.,Shapiro, L. Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide. Protein Sci. 2005 14 3004 3012 1ZXU X-ray structure of protein from arabidopsis thaliana AT5G01750 2005-06-08 2005-06-21 Center for Eukaryotic Structural Genomics (CESG) X-ray structure of protein from arabidopsis thaliana AT5G01750 To be published 0 0 0 0 2A2L Crystal structure of Klebsiella pneumoniae protein ORFY, Pfam DUF336 2005-06-22 2005-06-28 Ramagopal, U.,Patskovsky, Y.,Almo, S.C. Crystal Structure of Klebsiella Pneumoniae Hypothetical Protein Orfy To be Published 0 0 0 0 1ZKL 15994308 Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 2005-05-03 2005-07-05 Wang, H.,Liu, Y.,Chen, Y.,Robinson, H.,Ke, H. Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7 J.Biol.Chem. 2005 280 30949 30955 1ZL5 15938619 Crystal structure of Glu335Gln mutant of Clostridium botulinum neurotoxin E catalytic domain 2005-05-05 2005-07-05 Agarwal, R.,Binz, T.,Swaminathan, S. Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme. Biochemistry 2005 44 8291 8302 1YAU 15916965 Structure of Archeabacterial 20S proteasome- PA26 complex 2004-12-17 2005-07-26 Forster, A.,Masters, E.I.,Whitby, F.G.,Robinson, H.,Hill, C.P. The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Mol.Cell 2005 18 589 599 2A9F Crystal structure of a putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating)) 2005-07-11 2005-08-02 Seetharaman, J.,Swaminathan, S. Crystal structure of a putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating)) To be Published 0 0 0 0 2ABQ Crystal structure of fructose-1-phosphate kinase from Bacillus halodurans 2005-07-15 2005-08-02 Eswaramoorthy, S.,Swaminathan, S. Crystal structure of fructose-1-phosphate kinase from Bacillus halodurans To be Published 0 0 0 0 2AKO Crystal structure of Glutamate 5-kinase from Campylobacter jejuni 2005-08-03 2005-08-09 Gorman, J.,Shapiro, L. Crystal structure of Glutamate 5-kinase from Campylobacter jejuni To be Published 0 0 0 0 1YWO 16061254 Phospholipase Cgamma1 SH3 in complex with a SLP-76 motif 2005-02-18 2005-08-16 Deng, L.,Velikovsky, C.A.,Swaminathan, C.P.,Cho, S.,Mariuzza, R.A. Structural Basis for Recognition of the T Cell Adaptor Protein SLP-76 by the SH3 Domain of Phospholipase Cgamma1 J.Mol.Biol. 2005 352 1 10 1YWP 16061254 Phospholipase Cgamma1 SH3 2005-02-18 2005-08-16 Deng, L.,Velikovsky, C.A.,Swaminathan, C.P.,Cho, S.,Mariuzza, R.A. Structural Basis for Recognition of the T Cell Adaptor Protein SLP-76 by the SH3 Domain of Phospholipase Cgamma1 J.Mol.Biol. 2005 352 1 10 2AJT 16756997 Crystal structure of L-Arabinose Isomerase from E.coli 2005-08-02 2005-08-16 Manjasetty, B.A.,Chance, M.R. Crystal Structure of Escherichia coli L-Arabinose Isomerase (ECAI), The Putative Target of Biological Tagatose Production J.Mol.Biol. 2006 360 297 309 2AP9 Crystal structure of acetylglutamate kinase from Mycobacterium tuberculosis CDC1551 2005-08-15 2005-08-30 Rajashankar, K.R.,Kniewel, R.,Lee, K.,Lima, C.D. Crystal structure of acetylglutamate kinase from Mycobacterium tuberculosis CDC1551 To be Published 0 0 0 0 1XEV Crystal structure of human carbonic anhydrase II in a new crystal form 2004-09-13 2005-09-20 Mazumdar, P.A.,Kumaran, D.,Das, A.K.,Swaminathan, S. Crystal structure of human carbonic anhydrase II in a new crystal form To be Published 0 0 0 0 2A8A 16128577 Crystal structure of Clostridium botulinum neurotoxin serotype F light chain 2005-07-07 2005-09-20 Agarwal, R.,Binz, T.,Swaminathan, S. Structural analysis of botulinum neurotoxin serotype f light chain: implications on substrate binding and inhibitor design Biochemistry 2005 44 11758 11765 2B0A Crystal structure of protein MJ0783 from Methanococcus jannaschii 2005-09-13 2005-09-20 Patskovsky, Y.,Ramagopal, U.,Almo, S.C. Crystal Structure of Hypothetical Protein Mj0783 from Methanococcus Jannaschii To be Published 0 0 0 0 2B0O Crystal structure of UPLC1 GAP domain 2005-09-14 2005-09-20 Ismail, S.,Shen, L.,Arrowsmith, C.,Edwards, A.,Sundstrom, M.,Weigelt, J.,Bochkarev, A.,Park, H. Structural analysis of GAP and ankyrin domains of UPLC1 To be Published 0 0 0 0 1XEG 18323598 Crystal structure of human carbonic anhydrase II complexed with an acetate ion 2004-09-10 2005-09-27 Mazumdar, P.A.,Kumaran, D.,Swaminathan, S.,Das, A.K. A novel acetate-bound complex of human carbonic anhydrase II. Acta Crystallogr.,Sect.F 2008 64 163 166 2AHV 16253988 Crystal Structure of Acyl-CoA transferase from E. coli O157:H7 (YdiF)-thioester complex with CoA- 1 2005-07-28 2005-11-01 Rangarajan, E.S.,Li, Y.,Ajamian, E.,Iannuzzi, P.,Kernaghan, S.D.,Fraser, M.E.,Cygler, M.,Matte, A. Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases. J.Biol.Chem. 2005 280 42919 42928 2AHW 16253988 Crystal Structure of Acyl-CoA transferase from E. coli O157:H7 (YdiF)-thioester complex with CoA- 2 2005-07-28 2005-11-01 Rangarajan, E.S.,Li, Y.,Ajamian, E.,Iannuzzi, P.,Kernaghan, S.D.,Fraser, M.E.,Cygler, M.,Matte, A. Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases. J.Biol.Chem. 2005 280 42919 42928 2ETF Crystal structure of full length botulinum neurotoxin (Type B) light chain 2005-10-27 2005-12-06 Eswaramoorthy, S.,Swaminathan, S. Crystal structure of full length botulinum neurotoxin (Type B) light chain To be Published 0 0 0 0 2F4N 17910070 Crystal structure of protein MJ1651 from Methanococcus jannaschii DSM 2661, Pfam DUF62 2005-11-23 2005-12-06 Rao, K.N.,Burley, S.K.,Swaminathan, S. Crystal structure of a conserved protein of unknown function (MJ1651) from Methanococcus jannaschii. Proteins 2008 70 572 577 2B9C 16365313 Structure of tropomyosin's mid-region: bending and binding sites for actin 2005-10-11 2006-01-03 Brown, J.H.,Zhou, Z.,Reshetnikova, L.,Robinson, H.,Yammani, R.D.,Tobacman, L.S.,Cohen, C. Structure of the mid-region of tropomyosin: Bending and binding sites for actin. Proc.Natl.Acad.Sci.Usa 2005 102 18878 18883 2FNU 16421095 PseC aminotransferase with external aldimine 2006-01-11 2006-01-24 Schoenhofen, I.C.,Lunin, V.V.,Julien, J.P.,Li, Y.,Ajamian, E.,Matte, A.,Cygler, M.,Brisson, J.R.,Aubry, A.,Logan, S.M.,Bhatia, S.,Wakarchuk, W.W.,Young, N.M. Structural and Functional Characterization of PseC, an Aminotransferase Involved in the Biosynthesis of Pseudaminic Acid, an Essential Flagellar Modification in Helicobacter pylori J.Biol.Chem. 2006 281 8907 8916 2ESR conserved hypothetical protein- streptococcus pyogenes 2005-10-26 2006-02-07 Jiang, J.,Min, T.,Gorman, J.,Shapiro, L. Crystal Structure of hypothetical protein of Streptococcus Pygenes To be Published 0 0 0 0 1XXG Crystal Structure of Staphylococcal Enterotoxin G 2004-11-05 2006-02-21 Fernandez, M.M.,Bhattacharya, S.,Malchiodi, E.L.,Mariuzza, R.A. The Crystal Structure of Staphylococcal Enterotoxin G and binding affinity to T-cell receptor and MHC class II molecule To be Published 0 0 0 0 1Z3A 16700551 Crystal structure of tRNA adenosine deaminase TadA from Escherichia coli 2005-03-10 2006-02-21 Kim, J.,Malashkevich, V.,Roday, S.,Lisbin, M.,Schramm, V.L.,Almo, S.C. Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. Biochemistry 2006 45 6407 6416 1ZWI 16532009 Structure of mutant KcsA potassium channel 2005-06-03 2006-03-07 Cordero-Morales, J.F.,Cuello, L.G.,Zhao, Y.,Jogini, V.,Cortes, D.M.,Roux, B.,Perozo, E. Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol. 2006 13 311 318 2ATK 16532009 Structure of a mutant KcsA K+ channel 2005-08-25 2006-03-07 Cordero-Morales, J.F.,Cuello, L.G.,Zhao, Y.,Jogini, V.,Cortes, D.M.,Roux, B.,Perozo, E. Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol. 2006 13 311 318 2G6T Crystal structure of an uncharacterized protein from Clostridium acetobutylicum 2006-02-25 2006-03-14 Rao, K.N.,Swaminathan, S. Crystal structure of an uncharacterized protein from Clostridium acetobutylicum To be Published 0 0 0 0 2F8Y 16530044 Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution. 2005-12-04 2006-04-04 Nam, Y.,Sliz, P.,Song, L.,Aster, J.C.,Blacklow, S.C. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell(Cambridge,Mass.) 2006 124 973 983 2FIQ Crystal structure of putative tagatose 6-phosphate kinase 2005-12-30 2006-04-04 Ramagopal, U.A.,Fedorov, E.,Almo, S.C. Crystal structure of putative tagatose 6-phosphate kinase To be Published 0 0 0 0 2FCW 16630895 Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP). 2005-12-12 2006-05-16 Fisher, C.,Beglova, N.,Blacklow, S.C. Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors Mol.Cell 2006 22 277 283 2FJI 16699513 Crystal structure of the C-terminal domain of the exocyst subunit Sec6p 2006-01-02 2006-05-16 Sivaram, M.V.,Furgason, M.L.,Brewer, D.N.,Munson, M. The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles. Nat.Struct.Mol.Biol. 2006 13 555 556 2DLJ 17169989 2'-Me-Se and Br Derivitation of A-DNA Octamer G(UMS)G(BRU)ACAC 2006-04-19 2006-05-23 Jiang, J.,Sheng, J.,Carrasco, N.,Huang, Z. Selenium derivatization of nucleic acids for crystallography. Nucleic Acids Res. 2007 35 477 485 2FAO 16446439 Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain 2005-12-07 2006-05-23 Zhu, H.,Nandakumar, J.,Aniukwu, J.,Wang, L.K.,Glickman, M.S.,Lima, C.D.,Shuman, S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D Proc.Natl.Acad.Sci.USA 2006 103 1711 1716 2FAQ 16446439 Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with ATP and Manganese 2005-12-07 2006-05-23 Zhu, H.,Nandakumar, J.,Aniukwu, J.,Wang, L.K.,Glickman, M.S.,Lima, C.D.,Shuman, S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D Proc.Natl.Acad.Sci.USA 2006 103 1711 1716 2FAR 16446439 Crystal Structure of Pseudomonas aeruginosa LigD polymerase domain with dATP and Manganese 2005-12-07 2006-05-23 Zhu, H.,Nandakumar, J.,Aniukwu, J.,Wang, L.K.,Glickman, M.S.,Lima, C.D.,Shuman, S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D Proc.Natl.Acad.Sci.USA 2006 103 1711 1716 2FRJ 16777231 Nitrosyl Horse Heart Myoglobin, Nitrite/Dithionite Method 2006-01-19 2006-05-30 Copeland, D.M.,Soares, A.S.,West, A.H.,Richter-Addo, G.B. Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin. J.Inorg.Biochem. 2006 100 1413 1425 2FRK 16777231 Nitrosyl Horse Heart Myoglobin, Nitric Oxide Gas Method 2006-01-19 2006-05-30 Copeland, D.M.,Soares, A.S.,West, A.H.,Richter-Addo, G.B. Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin. J.Inorg.Biochem. 2006 100 1413 1425 2A0W 17407325 Structure of human purine nucleoside phosphorylase H257G mutant 2005-06-17 2006-06-06 Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L. Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry 2007 46 5038 5049 2A0X 17407325 Structure of human purine nucleoside phosphorylase H257F mutant 2005-06-17 2006-06-06 Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L. Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry 2007 46 5038 5049 2A0Y 17407325 Structure of human purine nucleoside phosphorylase H257D mutant 2005-06-17 2006-06-06 Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L. Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry 2007 46 5038 5049 2FLO 16678853 Crystal structure of exopolyphosphatase (PPX) from E. coli O157:H7 2006-01-06 2006-06-06 Rangarajan, E.S.,Nadeau, G.,Li, Y.,Wagner, J.,Hung, M.N.,Schrag, J.D.,Cygler, M.,Matte, A. The Structure of the Exopolyphosphatase (PPX) from Escherichia coli O157:H7 Suggests a Binding Mode for Long Polyphosphate Chains. J.Mol.Biol. 2006 359 1249 1260 2GPY Crystal structure of putative O-methyltransferase from Bacillus halodurans 2006-04-18 2006-06-06 Ramagopal, U.A.,Patskovsky, Y.V.,Almo, S.C. Crystal structure of putative O-methyltransferase from Bacillus halodurans To be Published 0 0 0 0 2GUW Crystal structure of AMP Nucleosidase from Salmonella typhimurium LT2 2006-05-01 2006-06-06 Rao, K.N.,Swaminathan, S. Crystal structure of AMP Nucleosidase from Salmonella typhimurium LT2 To be Published 0 0 0 0 2GY5 16732286 Tie2 Ligand-Binding Domain Crystal Structure 2006-05-09 2006-06-06 Barton, W.A.,Tzvetkova-Robev, D.,Miranda, E.P.,Kolev, M.V.,Rajashankar, K.R.,Himanen, J.P.,Nikolov, D.B. Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex. Nat.Struct.Mol.Biol. 2006 13 524 532 2GY7 16732286 Angiopoietin-2/Tie2 Complex Crystal Structure 2006-05-09 2006-06-06 Barton, W.A.,Tzvetkova-Robev, D.,Miranda, E.P.,Kolev, M.V.,Rajashankar, K.R.,Himanen, J.P.,Nikolov, D.B. Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex. Nat.Struct.Mol.Biol. 2006 13 524 532 2H40 16735511 Crystal structure of the catalytic domain of unliganded PDE5 2006-05-23 2006-06-06 Wang, H.,Liu, Y.,Huai, Q.,Cai, J.,Zoraghi, R.,Francis, S.H.,Corbin, J.D.,Robinson, H.,Xin, Z.,Lin, G.,Ke, H. Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem. 2006 281 21469 21479 2H42 16735511 Crystal structure of PDE5 in complex with sildenafil 2006-05-23 2006-06-06 Wang, H.,Liu, Y.,Huai, Q.,Cai, J.,Zoraghi, R.,Francis, S.H.,Corbin, J.D.,Robinson, H.,Xin, Z.,Lin, G.,Ke, H. Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem. 2006 281 21469 21479 2H44 16735511 Crystal structure of PDE5A1 in complex with icarisid II 2006-05-23 2006-06-06 Wang, H.,Liu, Y.,Huai, Q.,Cai, J.,Zoraghi, R.,Francis, S.H.,Corbin, J.D.,Robinson, H.,Xin, Z.,Lin, G.,Ke, H. 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Proteins 2008 72 1096 1103 2H68 16829959 Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex 2006-05-30 2006-07-04 Ruthenburg, A.J.,Wang, W.-K.,Graybosch, D.M.,Li, H.,Allis, C.D.,Patel, D.J.,Verdine, G.L. Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol. 2006 13 704 712 2HAE Crystal structure of a putative malic enzyme (malate oxidoreductase) 2006-06-12 2006-07-04 Seetharaman, J.,Swaminathan, S. Crystal structure of a putative malic enzyme (malate oxidoreductase) To be Published 0 0 0 0 2HAF Crystal structure of a putative translation repressor from Vibrio cholerae 2006-06-12 2006-07-04 Sugadev, R.,Seetharaman, J.,Kumaran, D.,Swaminathan, S. 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TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature 2006 442 303 306 2GXA 16855583 Crystal structure of papillomavirus E1 hexameric helicase with ssDNA and MgADP 2006-05-08 2006-07-25 Enemark, E.J.,Joshua-Tor, L. Mechanism of DNA translocation in a replicative hexameric helicase. Nature 2006 442 270 275 2FT0 16855251 Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA 2006-01-23 2006-08-01 Hung, M.N.,Rangarajan, E.,Munger, C.,Nadeau, G.,Sulea, T.,Matte, A. Crystal Structure of TDP-Fucosamine Acetyltransferase (WecD) from Escherichia coli, an Enzyme Required for Enterobacterial Common Antigen Synthesis. J.Bacteriol. 2006 188 5606 5617 2HD0 16862121 Structure of the catalytic domain of hepatitis C virus NS2 2006-06-19 2006-08-01 Lorenz, I.C.,Marcotrigiano, J.,Dentzer, T.G.,Rice, C.M. Structure of the catalytic domain of the hepatitis C virus NS2-3 protease. Nature 2006 442 831 835 2FUF 16611889 Crystal structure of the SV40 large T antigen origin-binding domain 2006-01-26 2006-08-22 Meinke, G.,Bullock, P.A.,Bohm, A. Crystal structure of the simian virus 40 large T-antigen origin-binding domain. J.Virol. 2006 80 4304 4312 2HV6 16916641 Crystal structure of the phosphotyrosyl phosphatase activator 2006-07-27 2006-08-22 Chao, Y.,Xing, Y.,Chen, Y.,Xu, Y.,Lin, Z.,Li, Z.,Jeffrey, P.D.,Stock, J.B.,Shi, Y. Structure and mechanism of the phosphotyrosyl phosphatase activator. Mol.Cell 2006 23 535 546 2HV7 16916641 Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS 2006-07-27 2006-08-22 Chao, Y.,Xing, Y.,Chen, Y.,Xu, Y.,Lin, Z.,Li, Z.,Jeffrey, P.D.,Stock, J.B.,Shi, Y. Structure and mechanism of the phosphotyrosyl phosphatase activator. Mol.Cell 2006 23 535 546 2FYU 16924113 Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor 2006-02-08 2006-08-29 Esser, L.,Gong, X.,Yang, S.,Yu, L.,Yu, C.A.,Xia, D. Surface-modulated motion switch: Capture and release of iron-sulfur protein in the cytochrome bc1 complex. Proc.Natl.Acad.Sci.Usa 2006 103 13045 13050 2HJ1 Crystal structure of a 3D domain-swapped dimer of protein HI0395 from Haemophilus influenzae 2006-06-29 2006-08-29 Ramagopal, U.A.,Patskovsky, Y.V.,Toro, R.,Almo, S.C. Crystal structure of a 3D domain-swapped dimer of hypothetical protein from Haemophilus influenzae (CASP Target) To be Published 0 0 0 0 2HZT Crystal Structure of a putative HTH-type transcriptional regulator ytcD 2006-08-09 2006-08-29 Madegowda, M.,Eswaramoorthy, S.,Desigan, K.,Burley, S.K.,Swaminathan, S. Crystal Structure of a putative HTH-type transcription regulator ytcD To be Published 0 0 0 0 2I44 18058037 Crystal structure of serine-threonine phosphatase 2C from Toxoplasma gondii 2006-08-21 2006-08-29 Almo, S.C.,Bonanno, J.B.,Sauder, J.M.,Emtage, S.,Dilorenzo, T.P.,Malashkevich, V.,Wasserman, S.R.,Swaminathan, S.,Eswaramoorthy, S.,Agarwal, R.,Kumaran, D.,Madegowda, M.,Ragumani, S.,Patskovsky, Y.,Alvarado, J.,Ramagopal, U.A.,Faber-Barata, J.,Chance, M.R.,Sali, A.,Fiser, A.,Zhang, Z.Y.,Lawrence, D.S.,Burley, S.K. Structural genomics of protein phosphatases. J.Struct.Funct.Genom. 2007 8 121 140 1ZYL 17302814 Crystal Structure of Hypothetical Protein YihE from Escherichia coli 2005-06-10 2006-09-19 Zheng, J.,He, C.,Singh, V.K.,Martin, N.L.,Jia, Z. Crystal structure of a novel prokaryotic Ser/Thr kinase and its implication in the Cpx stress response pathway. Mol.Microbiol. 2007 63 1360 1371 2GHV 16954221 Crystal structure of SARS spike protein receptor binding domain 2006-03-27 2006-09-19 Hwang, W.C.,Lin, Y.,Santelli, E.,Sui, J.,Jaroszewski, L.,Stec, B.,Farzan, M.,Marasco, W.A.,Liddington, R.C. Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. J.Biol.Chem. 2006 281 34610 34616 2H7O 16959567 Crystal structure of the Rho-GTPase binding domain of YpkA 2006-06-02 2006-09-19 Prehna, G.,Ivanov, M.I.,Bliska, J.B.,Stebbins, C.E. Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors. Cell(Cambridge,Mass.) 2006 126 869 880 2H7V 16959567 Co-crystal structure of YpkA-Rac1 2006-06-04 2006-09-19 Prehna, G.,Ivanov, M.I.,Bliska, J.B.,Stebbins, C.E. Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors. Cell(Cambridge,Mass.) 2006 126 869 880 2H7V 16959567 Co-crystal structure of YpkA-Rac1 2006-06-04 2006-09-19 Prehna, G.,Ivanov, M.I.,Bliska, J.B.,Stebbins, C.E. Yersinia virulence depends on mimicry of host rho-family nucleotide dissociation inhibitors. Cell(Cambridge,Mass.) 2006 126 869 880 2HTL 16949616 Structure of the Escherichia coli ClC chloride channel Y445F mutant and Fab complex 2006-07-26 2006-09-19 Accardi, A.,Lobet, S.,Williams, C.,Miller, C.,Dutzler, R. Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger. J.Mol.Biol. 2006 362 691 699 2I9U Crystal Structure of Guanine Deaminase from C. acetobutylicum with bound guanine in the active site 2006-09-06 2006-09-19 Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal Structure of Guanine Deaminase from C. acetobutylicum with bound guanine in the active site To be Published 0 0 0 0 2G83 16981699 Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit 2006-03-01 2006-10-10 Johnston, C.A.,Lobanova, E.S.,Shavkunov, A.S.,Low, J.,Ramer, J.K.,Blaesius, R.,Fredericks, Z.,Willard, F.S.,Kuhlman, B.,Arshavsky, V.Y.,Siderovski, D.P. Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer. Biochemistry 2006 45 11390 11400 2HVQ 17018278 Structure of Adenylated full-length T4 RNA Ligase 2 2006-07-30 2006-10-17 Nandakumar, J.,Shuman, S.,Lima, C.D. RNA Ligase Structures Reveal the Basis for RNA Specificity and Conformational Changes that Drive Ligation Forward. Cell(Cambridge,Mass.) 2006 127 71 84 2I5W 17015827 Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG 2006-08-26 2006-10-17 Banerjee, A.,Verdine, G.L. A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex. Proc.Natl.Acad.Sci.Usa 2006 103 15020 15025 2ICS Crystal structure of an adenine deaminase 2006-09-13 2006-10-17 Sugadev, R.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of an adenine deaminase TO BE PUBLISHED 0 0 0 0 2IF7 17045824 Crystal Structure of NTB-A 2006-09-20 2006-10-17 Cao, E.,Ramagopal, U.A.,Fedorov, A.,Fedorov, E.,Yan, Q.,Lary, J.W.,Cole, J.L.,Nathenson, S.G.,Almo, S.C. NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family. Immunity 2006 25 559 570 2IM9 Crystal structure of protein LPG0564 from Legionella pneumophila str. Philadelphia 1, Pfam DUF1460 2006-10-04 2006-10-17 Bonanno, J.B.,Freeman, J.,Bain, K.T.,Powell, A.,Ozyurt, S.,Wasserman, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of hypothetical protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 TO BE PUBLISHED 0 0 0 0 2IMG 18245086 Crystal structure of dual specificity protein phosphatase 23 from Homo sapiens in complex with ligand malate ion 2006-10-04 2006-10-17 Agarwal, R.,Burley, S.K.,Swaminathan, S. Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex. J.Biol.Chem. 2008 283 8946 8953 2IMH Crystal structure of protein SPO2555 from Silicibacter pomeroyi, Pfam DUF1028 2006-10-04 2006-10-17 Bonanno, J.B.,Dickey, M.,Bain, K.T.,Slocombe, A.,Ozyurt, S.,Wasserman, S.,Burley, S.K.,Almo, S.C. Crystal structure of hypothetical protein from Silicibacter pomeroyi To be Published 0 0 0 0 2IML Crystal structure of a hypothetical protein from Archaeoglobus fulgidus binding riboflavin 5'-phosphate 2006-10-04 2006-10-17 Bonanno, J.B.,Dickey, M.,Bain, K.T.,Adams, J.,Ozyurt, S.,Wasserman, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of a hypothetical protein from Archaeoglobus fulgidus binding riboflavin 5'-phosphate To be Published 0 0 0 0 2HTH 17057716 Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain 2006-07-25 2006-10-24 Alam, S.L.,Langelier, C.,Whitby, F.G.,Koirala, S.,Robinson, H.,Hill, C.P.,Sundquist, W.I. Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nat.Struct.Mol.Biol. 2006 13 1029 1030 2IJQ Crystal structure of protein rrnAC1037 from Haloarcula marismortui, Pfam DUF309 2006-09-30 2006-10-24 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Thompson, D.A.,Rutter, M.E.,Dickey, M.,Groshong, C.,Bain, K.T.,Adams, J.M.,Reyes, C.,Rooney, I.,Powell, A.,Boice, A.,Gheyi, T.,Ozyurt, S.,Atwell, S.,Wasserman, S.R.,Schwinn, K.D.,Emtage, S.,Burley, S.K.,Almo, S.C. Crystal structure of the hypothetical Protein from Haloarcula marismortui To be Published 0 0 0 0 2F8S 17027504 Crystal structure of Aa-Ago with externally-bound siRNA 2005-12-03 2006-10-31 Yuan, Y.R.,Pei, Y.,Chen, H.Y.,Tuschl, T.,Patel, D.J. A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA. Structure 2006 14 1557 1565 2IJR Crystal structure of a protein api92 from Yersinia pseudotuberculosis, Pfam DUF1281 2006-09-30 2006-10-31 Jin, X.,Min, T.,Bonanno, J.B.,Sauder, J.M.,Wasserman, S.,Smith, D.,Burley, S.K.,Shapiro, L. Crystal structure of a hypothetical protein from Yersinia pseudotuberculosis To be Published 0 0 0 0 2IOJ Crystal structure of protein AF1212 from Archaeoglobus fulgidus, Pfam DRTGG 2006-10-10 2006-10-31 Tyagi, R.,Burley, S.K.,Swaminathan, S. The crystal structure of a hypothetical protein (Y1212_ARCFU) from Archeoglobus fulgidus To be Published 0 0 0 0 2F3L 17075135 Crystal Structure of a Lumenal Rfr-domain protein (Contig83.1_1_243_746) from Cyanothece sp. 51142 at 2.1 Angstrom resolution. 2005-11-21 2006-11-07 Buchko, G.W.,Ni, S.,Robinson, H.,Welsh, E.A.,Pakrasi, H.B.,Kennedy, M.A. Characterization of two potentially universal turn motifs that shape the repeated five-residues fold-Crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142. Protein Sci. 2006 15 2579 2595 2F3L 17075135 Crystal Structure of a Lumenal Rfr-domain protein (Contig83.1_1_243_746) from Cyanothece sp. 51142 at 2.1 Angstrom resolution. 2005-11-21 2006-11-07 Buchko, G.W.,Ni, S.,Robinson, H.,Welsh, E.A.,Pakrasi, H.B.,Kennedy, M.A. Characterization of two potentially universal turn motifs that shape the repeated five-residues fold-Crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142. Protein Sci. 2006 15 2579 2595 2G0Y 17075135 Crystal Structure of a Lumenal Pentapeptide Repeat Protein from Cyanothece sp 51142 at 2.3 Angstrom Resolution. Tetragonal Crystal Form 2006-02-13 2006-11-07 Buchko, G.W.,Ni, S.,Robinson, H.,Welsh, E.A.,Pakrasi, H.B.,Kennedy, M.A. Characterization of two potentially universal turn motifs that shape the repeated five-residues fold - Crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142 Protein Sci. 2006 15 2579 2595 2IPQ Crystal structure of C-terminal domain of Salmonella Enterica protein STY4665, PFAM DUF1528 2006-10-12 2006-11-07 Ramagopal, U.A.,Bonanno, J.B.,Gilmore, J.,Toro, R.,Bain, K.T.,Reyes, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,New York SGX Research Center for Structural Genomics (NYSGXRC) Structure of C-terminal domain of Hypothetical protein STY4665 To be Published 0 0 0 0 2NLY Crystal structure of protein BH1492 from Bacillus halodurans, Pfam DUF610 2006-10-20 2006-11-07 Jin, X.,Sauder, J.M.,Wasserman, S.,Smith, D.,Burley, S.K.,Shapiro, L. Crystal structure of hypothetical protein BH1492 from Bacillus halodurans C-125 To be Published 0 0 0 0 2IJZ Crystal structure of aminopeptidase 2006-10-02 2006-11-14 Min, T.,Burley, S.K.,Shapiro, L. Crystal structrue of putative aminopeptidase 2 from Pseudomonas Aeruginosa To be Published 0 0 0 0 2IO3 17099700 Crystal structure of human Senp2 in complex with RanGAP1-SUMO-2 2006-10-09 2006-11-14 Reverter, D.,Lima, C.D. Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat.Struct.Mol.Biol. 2006 13 1060 1068 2IRM 18058037 Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae 2006-10-15 2006-11-14 Almo, S.C.,Bonanno, J.B.,Sauder, J.M.,Emtage, S.,Dilorenzo, T.P.,Malashkevich, V.,Wasserman, S.R.,Swaminathan, S.,Eswaramoorthy, S.,Agarwal, R.,Kumaran, D.,Madegowda, M.,Ragumani, S.,Patskovsky, Y.,Alvarado, J.,Ramagopal, U.A.,Faber-Barata, J.,Chance, M.R.,Sali, A.,Fiser, A.,Zhang, Z.Y.,Lawrence, D.S.,Burley, S.K. Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM. 2007 8 121 140 2NQL Crystal structure of a member of the enolase superfamily from Agrobacterium tumefaciens 2006-10-31 2006-11-14 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Sauder, J.M.,Dickey, M.,Adams, J.M.,Ozyurt, S.,Wasserman, S.R.,Gerlt, J.,Burley, S.K.,Almo, S.C. Crystal Structure of Enolase from Agrobacterium Tumefaciens C58 To be Published 0 0 0 0 2NRF 17099694 Crystal Structure of GlpG, a Rhomboid family intramembrane protease 2006-11-02 2006-11-14 Wu, Z.,Yan, N.,Feng, L.,Oberstein, A.,Yan, H.,Baker, R.P.,Gu, L.,Jeffrey, P.D.,Urban, S.,Shi, Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat.Struct.Mol.Biol. 2006 13 1084 1091 2IAK 17161423 Crystal Structure of a protease resistant fragment of the plakin domain of Bullous Pemphigoid Antigen1 (BPAG1) 2006-09-08 2006-11-28 Jefferson, J.J.,Ciatto, C.,Shapiro, L.,Liem, R.K. Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily. J.Mol.Biol. 2007 366 244 257 2NPP 17174897 Structure of the Protein Phosphatase 2A Holoenzyme 2006-10-28 2006-12-12 Xu, Y.,Xing, Y.,Chen, Y.,Chao, Y.,Lin, Z.,Fan, E.,Yu, J.W.,Strack, S.,Jeffrey, P.D.,Shi, Y. Structure of the protein phosphatase 2A holoenzyme Cell(Cambridge,Mass.) 2006 127 1239 1251 2NYL 17174897 Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated 2006-11-20 2006-12-12 Xu, Y.,Xing, Y.,Chen, Y.,Chao, Y.,Lin, Z.,Fan, E.,Yu, J.W.,Strack, S.,Jeffrey, P.D.,Shi, Y. Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.) 2006 127 1239 1251 2NYM 17174897 Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit 2006-11-21 2006-12-12 Xu, Y.,Xing, Y.,Chen, Y.,Chao, Y.,Lin, Z.,Fan, E.,Yu, J.W.,Strack, S.,Jeffrey, P.D.,Shi, Y. Structure of the Protein Phosphatase 2A Holoenzyme. Cell(Cambridge,Mass.) 2006 127 1239 1251 2O3J Structure of Caenorhabditis Elegans UDP-Glucose Dehydrogenase 2006-12-01 2006-12-12 Zhang, Y.,Zhan, C.,Patskovsky, Y.,Ramagopal, U.,Shi, W.,Toro, R.,Wengerter, B.C.,Milstein, S.,Vidal, M.,Burley, S.K.,Almo, S.C. Crystal Structure of Caenorhabditis Elegans Udp-Glucose Dehydrogenase To be Published 0 0 0 0 2NX2 Crystal structure of protein ypsA from Bacillus subtilis, Pfam DUF1273 2006-11-16 2006-12-19 Ramagopal, U.A.,Alvarado, J.,Dickey, M.,Reyes, C.,Toro, R.,Bain, K.,Gheyi, T.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,New York SGX Research Center for Structural Genomics Crystal structure of hypothetical protein ypsA from Bacillus subtilis. To be Published 0 0 0 0 2NXO Crystal structure of protein SCO4506 from Streptomyces coelicolor, Pfam DUF178 2006-11-17 2006-12-19 Tyagi, R.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. The crystal structure of a hypothetical protein SCO4506 (gene ID: Q9L0T8) from Streptomyces coelicolor to 2.04 Angstrom resolution To be Published 0 0 0 0 2IQH 17151603 Influenza A virus nucleoprotein NP at 3.2A resolution 2006-10-13 2006-12-26 Ye, Q.,Krug, R.M.,Tao, Y.J. The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 2006 444 1078 1082 2I53 17169370 Crystal structure of Cyclin K 2006-08-23 2007-01-02 Baek, K.,Brown, R.S.,Birrane, G.,Ladias, J.A. Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9. J.Mol.Biol. 2007 366 563 573 2FLE 18215016 Structural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutant 2006-01-05 2007-01-16 Clemente, J.C.,Robbins, A.,Grana, P.,Paleo, M.R.,Correa, J.F.,Villaverde, M.C.,Sardina, F.J.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Dunn, B.M.,Sussman, F. Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation. J.Med.Chem. 2008 51 852 860 2FLE 18215016 Structural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutant 2006-01-05 2007-01-16 Clemente, J.C.,Robbins, A.,Grana, P.,Paleo, M.R.,Correa, J.F.,Villaverde, M.C.,Sardina, F.J.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Dunn, B.M.,Sussman, F. Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation. J.Med.Chem. 2008 51 852 860 2E4O 17261032 X-ray Crystal Structure of Aristolochene Synthase from Aspergillus terreus and the Evolution of Templates for the Cyclization of Farnesyl Diphosphate 2006-12-15 2007-01-23 Shishova, E.Y.,Di Costanzo, L.,Cane, D.E.,Christianson, D.W. X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate. Biochemistry 2007 46 1941 1951 2HHP 17223131 Structure of yeast poly(A) polymerase in a closed conformation. 2006-06-28 2007-01-23 Balbo, P.B.,Toth, J.,Bohm, A. X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase. J.Mol.Biol. 2007 366 1401 1415 2O09 17215864 Crystal structure of the H-NOX domain from Nostoc sp. PCC 7120 2006-11-27 2007-01-30 Ma, X.,Sayed, N.,Beuve, A.,van den Akker, F. NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism. Embo J. 2007 26 578 588 2OB3 Structure of Phosphotriesterase mutant H257Y/L303T 2006-12-18 2007-01-30 Kim, J.,Ramagopal, U.A.,Tsai, P.,Raushel, F.M.,Almo, S.C. Structure of Phosphotriesterase mutant H257Y/L303T To be Published 0 0 0 0 2OO2 Crystal structure of protein AF1782 from Archaeoglobus fulgidus, Pfam DUF357 2007-01-25 2007-02-06 Bonanno, J.B.,Rutter, M.,Bain, K.T.,Adams, J.,Sridhar, V.,Smyth, L.,Freeman, J.,Atwell, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of the hypothetical AF_1782 protein from Archaeoglobus fulgidus To be Published 0 0 0 0 2OO3 Crystal structure of protein LPL1258 from Legionella pneumophila str. Philadelphia 1, Pfam DUF519 2007-01-25 2007-02-06 Bonanno, J.B.,Freeman, J.,Bain, K.T.,Slocombe, A.,Reyes, C.,Ozyurt, S.,Smyth, L.,Atwell, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of the hypothetical lpl1258 protein from Legionella pneumophila To be Published 0 0 0 0 2OO6 Crystal structure of putative L-alanine-DL-glutamate epimerase from Burkholderia xenovorans strain LB400 2007-01-25 2007-02-06 Bonanno, J.B.,Dickey, M.,Bain, K.T.,Wu, B.,Sridhar, V.,Freeman, J.,Smyth, L.,Atwell, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative L-alanine-DL-glutamate epimerase from Burkholderia xenovorans strain LB400 To be Published 0 0 0 0 2IF9 17253903 Crystal Structure of SV40 T-antigen origin binding domain disulfide-linked dimer 2006-09-20 2007-02-13 Meinke, G.,Phelan, P.,Moine, S.,Bochkareva, E.,Bochkarev, A.,Bullock, P.A.,Bohm, A. The Crystal Structure of the SV40 T-Antigen Origin Binding Domain in Complex with DNA Plos Biol. 2007 5 0 0 2NTC 17253903 Crystal Structure of sv40 large T antigen origin binding domain with DNA 2006-11-07 2007-02-13 Meinke, G.,Phelan, P.,Moine, S.,Bochkareva, E.,Bochkarev, A.,Bullock, P.A.,Bohm, A. The Crystal Structure of the SV40 T-Antigen Origin Binding Domain in Complex with DNA Plos Biol. 2007 5 0 0 2OJ5 17303562 Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain wild-type at 1.75 A resolution 2007-01-12 2007-02-13 Schelling, P.,Guglielmi, K.M.,Kirchner, E.,Paetzold, B.,Dermody, T.S.,Stehle, T. The Reovirus Sigma1 Aspartic Acid Sandwich: A TRIMERIZATION MOTIF POISED FOR CONFORMATIONAL CHANGE. J.Biol.Chem. 2007 282 11582 11589 2HVK 17196615 crystal structure of the KcsA-Fab-TBA complex in high K+ 2006-07-28 2007-02-20 Yohannan, S.,Hu, Y.,Zhou, Y. Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel. J.Mol.Biol. 2007 366 806 814 2OOD Crystal structure of guanine deaminase from Bradyrhizobium japonicum 2007-01-25 2007-02-20 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of guanine deaminase from Bradyrhizobium japonicum To be Published 0 0 0 0 2NWL 17230192 Crystal structure of GltPh in complex with L-Asp 2006-11-15 2007-02-27 Boudker, O.,Ryan, R.M.,Yernool, D.,Shimamoto, K.,Gouaux, E. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature 2007 445 387 393 2NWX 17230192 Crystal structure of GltPh in complex with L-aspartate and sodium ions 2006-11-16 2007-02-27 Boudker, O.,Ryan, R.M.,Yernool, D.,Shimamoto, K.,Gouaux, E. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature 2007 445 387 393 2O3Z 17296300 X-ray crystal structure of LpxC complexed with 3-heptyloxybenzoate 2006-12-02 2007-02-27 Shin, H.,Gennadios, H.A.,Whittington, D.A.,Christianson, D.W. Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC. Bioorg.Med.Chem. 2007 15 2617 2623 2OVB 17329243 Crystal Structure of StaL-sulfate complex 2007-02-13 2007-02-27 Shi, R.,Lamb, S.S.,Bhat, S.,Sulea, T.,Wright, G.D.,Matte, A.,Cygler, M. Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis. J.Biol.Chem. 2007 282 13073 13086 2OQY 19883118 The crystal structure of muconate cycloisomerase from Oceanobacillus iheyensis 2007-02-01 2007-03-06 Rakus, J.F.,Kalyanaraman, C.,Fedorov, A.A.,Fedorov, E.V.,Mills-Groninger, F.P.,Toro, R.,Bonanno, J.,Bain, K.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Jacobson, M.P.,Gerlt, J.A. Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis . Biochemistry 2009 48 11546 11558 2P27 18058037 Crystal Structure of Human Pyridoxal Phosphate Phosphatase with Mg2+ at 1.9 A resolution 2007-03-07 2007-03-13 Almo, S.C.,Bonanno, J.B.,Sauder, J.M.,Emtage, S.,Dilorenzo, T.P.,Malashkevich, V.,Wasserman, S.R.,Swaminathan, S.,Eswaramoorthy, S.,Agarwal, R.,Kumaran, D.,Madegowda, M.,Ragumani, S.,Patskovsky, Y.,Alvarado, J.,Ramagopal, U.A.,Faber-Barata, J.,Chance, M.R.,Sali, A.,Fiser, A.,Zhang, Z.Y.,Lawrence, D.S.,Burley, S.K. Structural genomics of protein phosphatases. J.Struct.Funct.Genom. 2007 8 121 140 2OUN 17389385 crystal structure of PDE10A2 in complex with AMP 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OUP 17389385 crystal structure of PDE10A 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OUQ 17389385 crystal structure of PDE10A2 in complex with GMP 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OUR 17389385 crystal structure of PDE10A2 mutant D674A in complex with cAMP 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OUS 17389385 crystal structure of PDE10A2 mutant D674A 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OUU 17389385 crystal structure of PDE10A2 mutant D674A in complex with cGMP 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OUV 17389385 crystal structure of pde10a2 mutant of D564N 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OUY 17389385 crystal structure of pde10a2 mutant D564A in complex with cAMP. 2007-02-12 2007-03-20 Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa 2007 104 5782 5787 2OVL Crystal structure of a racemase from Streptomyces coelicolor A3(2) 2007-02-14 2007-03-20 Rao, K.N.,Burley, S.K.,Swaminathan, S. Crystal structure of a racemase from Streptomyces coelicolor A3(2) To be Published 0 0 0 0 2P2E Crystal structure of a putative Fe-S biosynthesis protein from Lactobacillus salivarius with novel protein fold 2007-03-07 2007-03-20 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative Fe-S biosynthesis protein from Lactobacillus salivarius with novel protein fold To be Published 0 0 0 0 2JBY 17386268 A viral protein unexpectedly mimics the structure and function of pro- survival Bcl-2 2006-12-14 2007-03-27 Kvansakul, M.,van Delft, M.F.,Lee, E.F.,Gulbis, J.M.,Fairlie, W.D.,Huang, D.C.,Colman, P.M. A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak. Mol. Cell 2007 25 933 942 2NL9 17389404 Crystal structure of the Mcl-1:Bim BH3 complex 2006-10-19 2007-03-27 Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc.Natl.Acad.Sci.USA 2007 104 6217 6222 2NLA 17389404 Crystal structure of the Mcl-1:mNoxaB BH3 complex 2006-10-19 2007-03-27 Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc.Natl.Acad.Sci.USA 2007 104 6217 6222 2OEV 17350572 Crystal structure of ALIX/AIP1 2007-01-01 2007-03-27 Fisher, R.D.,Chung, H.Y.,Zhai, Q.,Robinson, H.,Sundquist, W.I.,Hill, C.P. Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding Cell(Cambridge,Mass.) 2007 128 841 852 2OEX 17350572 Structure of ALIX/AIP1 V Domain 2007-01-01 2007-03-27 Fisher, R.D.,Chung, H.Y.,Zhai, Q.,Robinson, H.,Sundquist, W.I.,Hill, C.P. Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding Cell(Cambridge,Mass.) 2007 128 841 852 2GBB 18727669 Crystal structure of secreted chorismate mutase from Yersinia pestis 2006-03-10 2007-04-03 Kim, S.K.,Reddy, S.K.,Nelson, B.C.,Robinson, H.,Reddy, P.T.,Ladner, J.E. A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H(37)R(v) and the secreted chorismate mutase (y2828) from Yersinia pestis. Febs J. 2008 275 4824 4835 2IAL 17334368 Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR 2006-09-08 2007-04-03 Deng, L.,Langley, R.J.,Brown, P.H.,Xu, G.,Teng, L.,Wang, Q.,Gonzales, M.I.,Callender, G.G.,Nishimura, M.I.,Topalian, S.L.,Mariuzza, R.A. Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor Nat.Immunol. 2007 8 398 408 2ITQ 17349580 Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941 2006-05-25 2007-04-03 Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell 2007 11 217 0 2OO4 17401372 Structure of LNR-HD (Negative Regulatory Region) from human Notch 2 2007-01-25 2007-04-03 Gordon, W.R.,Vardar-Ulu, D.,Histen, G.,Sanchez-Irizarry, C.,Aster, J.C.,Blacklow, S.C. Structural basis for autoinhibition of Notch Nat.Struct.Mol.Biol. 2007 14 295 300 2OTJ 17321546 13-deoxytedanolide bound to the large subunit of Haloarcula marismortui 2007-02-08 2007-04-03 Schroeder, S.J.,Blaha, G.,Tirado-Rives, J.,Steitz, T.A.,Moore, P.B. The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole. J.Mol.Biol. 2007 367 1471 1479 2OTL 17321546 Girodazole bound to the large subunit of Haloarcula marismortui 2007-02-08 2007-04-03 Schroeder, S.J.,Blaha, G.,Tirado-Rives, J.,Steitz, T.A.,Moore, P.B. The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole. J.Mol.Biol. 2007 367 1471 1479 2P67 Crystal structure of LAO/AO transport system kinase 2007-03-16 2007-04-03 Ramagopal, U.A.,Adams, J.,Rodgers, L.,Toro, R.,Bain, K.,Rutter, M.,Schwinn, K.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of LAO/AO transport system kinase To be Published 0 0 0 0 2P69 18058037 Crystal Structure of Human Pyridoxal Phosphate Phosphatase with PLP 2007-03-16 2007-04-03 Almo, S.C.,Bonanno, J.B.,Sauder, J.M.,Emtage, S.,Dilorenzo, T.P.,Malashkevich, V.,Wasserman, S.R.,Swaminathan, S.,Eswaramoorthy, S.,Agarwal, R.,Kumaran, D.,Madegowda, M.,Ragumani, S.,Patskovsky, Y.,Alvarado, J.,Ramagopal, U.A.,Faber-Barata, J.,Chance, M.R.,Sali, A.,Fiser, A.,Zhang, Z.Y.,Lawrence, D.S.,Burley, S.K. Structural genomics of protein phosphatases. J.Struct.Funct.Genom. 2007 8 121 140 2P9B Crystal structure of putative prolidase from Bifidobacterium longum 2007-03-24 2007-04-03 Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of putative prolidase from Bifidobacterium longum To be Published 0 0 0 0 2PAJ 20415463 Crystal structure of an amidohydrolase from an environmental sample of Sargasso sea 2007-03-27 2007-04-03 Hall, R.S.,Agarwal, R.,Hitchcock, D.,Sauder, J.M.,Burley, S.K.,Swaminathan, S.,Raushel, F.M. Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase. Biochemistry 2010 49 4374 4382 2PBN 18058037 Crystal structure of the human tyrosine receptor phosphate gamma 2007-03-28 2007-04-03 Almo, S.C.,Bonanno, J.B.,Sauder, J.M.,Emtage, S.,Dilorenzo, T.P.,Malashkevich, V.,Wasserman, S.R.,Swaminathan, S.,Eswaramoorthy, S.,Agarwal, R.,Kumaran, D.,Madegowda, M.,Ragumani, S.,Patskovsky, Y.,Alvarado, J.,Ramagopal, U.A.,Faber-Barata, J.,Chance, M.R.,Sali, A.,Fiser, A.,Zhang, Z.Y.,Lawrence, D.S.,Burley, S.K. Structural genomics of protein phosphatases. J.Struct.Funct.Genom. 2007 8 121 140 2OYP 17363302 T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface 2007-02-22 2007-04-10 Cao, E.,Zang, X.,Ramagopal, U.A.,Mukhopadhaya, A.,Fedorov, A.A.,Fedorov, E.V.,Zencheck, W.D.,Lary, J.W.,Cole, J.L.,Deng, H.,Xiao, H.,Dilorenzo, T.P.,Allison, J.P.,Nathenson, S.G.,Almo, S.C. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface Immunity 2007 26 311 321 2PB9 Crystal structure of C-terminal domain of phosphomethylpyrimidine kinase 2007-03-28 2007-04-10 Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of C-terminal domain of phosphomethylpyrimidine kinase To be Published 0 0 0 0 2PBE Crystal structure of an aminoglycoside 6-adenyltransferase from Bacillus subtilis 2007-03-28 2007-04-10 Tyagi, R.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. The crystal structure of an aminoglycoside 6-adenyltransferase from Bacillus subtilis To be Published 0 0 0 0 2PBZ Crystal structure of an IMP biosynthesis protein PurP from Thermococcus kodakaraensis 2007-03-29 2007-04-10 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of an IMP biosynthesis protein PurP from Thermococcus kodakaraensis To be Published 0 0 0 0 2PGE 24872444 Crystal structure of MenC from Desulfotalea psychrophila LSv54 2007-04-09 2007-04-24 Odokonyero, D.,Sakai, A.,Patskovsky, Y.,Malashkevich, V.N.,Fedorov, A.A.,Bonanno, J.B.,Fedorov, E.V.,Toro, R.,Agarwal, R.,Wang, C.,Ozerova, N.D.,Yew, W.S.,Sauder, J.M.,Swaminathan, S.,Burley, S.K.,Almo, S.C.,Glasner, M.E. Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family. Proc.Natl.Acad.Sci.USA 2014 111 8535 8540 2PGS Crystal structure of a putative deoxyguanosinetriphosphate triphosphohydrolase from Pseudomonas syringae pv. phaseolicola 1448A 2007-04-10 2007-04-24 Rao, K.N.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative deoxyguanosinetriphosphate triphosphohydrolase from Pseudomonas syringae pv. phaseolicola 1448A at 2.35 A resolution To be Published 0 0 0 0 2PGW Crystal structure of a putative muconate cycloisomerase from Sinorhizobium meliloti 1021 2007-04-10 2007-04-24 Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative muconate cycloisomerase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 2PKG 17529992 Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40 2007-04-17 2007-05-15 Chen, Y.,Xu, Y.,Bao, Q.,Xing, Y.,Li, Z.,Lin, Z.,Stock, J.B.,Jeffrey, P.D.,Shi, Y. Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40. Nat.Struct.Mol.Biol. 2007 14 527 534 2POF Crystal structure of CDP-diacylglycerol pyrophosphatase 2007-04-26 2007-05-15 Madegowda, M.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of CDP-diacylglycerol pyrophosphatase. To be Published 0 0 0 0 2POZ Crystal structure of a putative dehydratase from Mesorhizobium loti 2007-04-27 2007-05-15 Sugadev, R.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative dehydratase from Mesorhizobium loti. To be Published 0 0 0 0 2PTF Crystal structure of protein MTH_863 from Methanobacterium thermoautotrophicum bound to FMN 2007-05-08 2007-05-15 Bonanno, J.B.,Rutter, M.,Bain, K.T.,Iizuka, M.,Ozyurt, S.,Smith, D.,Wasserman, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of protein MTH_863 from Methanobacterium thermoautotrophicum bound to FMN. To be Published 0 0 0 0 2OC4 17407325 Crystal structure of human purine nucleoside phosphorylase mutant H257D with Imm-H 2006-12-20 2007-05-22 Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L. Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase Biochemistry 2007 46 5038 5049 2OC9 17407325 Crystal structure of human purine nucleoside phosphorylase mutant H257G with Imm-H 2006-12-20 2007-05-22 Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L. Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase Biochemistry 2007 46 5038 5049 2ON6 17407325 Crystal structure of human purine nucleoside phosphorylase mutant H257F with Imm-H 2007-01-23 2007-05-22 Murkin, A.S.,Birck, M.R.,Rinaldo-Matthis, A.,Shi, W.,Taylor, E.A.,Almo, S.C.,Schramm, V.L. Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase Biochemistry 2007 46 5038 5049 2PFV 17583731 S. cerevisiae Exo70 with additional residues to 2.1 Angrstrom resolution 2007-04-05 2007-05-22 Moore, B.A.,Robinson, H.H.,Xu, Z. The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst. J.Mol.Biol. 2007 371 410 421 2PJU Crystal structure of propionate catabolism operon regulatory protein prpR 2007-04-16 2007-05-22 Ramagopal, U.A.,Toro, R.,Gilmore, M.,Wu, B.,Koss, J.,Groshong, C.,Gheyi, T.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of propionate catabolism operon regulatory protein prpR To be Published 0 0 0 0 2PPG Crystal structure of putative isomerase from Sinorhizobium meliloti 2007-04-30 2007-05-22 Ramagopal, U.A.,Toro, R.,Dickey, M.,Logan, C.,Groshong, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative isomerase from Sinorhizobium meliloti. To be Published 0 0 0 0 2PWW Crystal structure of ABC2387 from Bacillus clausii 2007-05-14 2007-05-22 Ramagopal, U.A.,Freeman, J.,Lau, C.,Toro, R.,Bain, K.,Rodgers, L.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of ABC2387 from Bacillus clausii. To be Published 0 0 0 0 2P9L 17499050 Crystal Structure of bovine Arp2/3 complex 2007-03-26 2007-05-29 Nolen, B.J.,Pollard, T.D. Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell 2007 26 449 457 2P9N 17499050 Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP 2007-03-26 2007-05-29 Nolen, B.J.,Pollard, T.D. Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell 2007 26 449 457 2P9P 17499050 Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP 2007-03-26 2007-05-29 Nolen, B.J.,Pollard, T.D. Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell 2007 26 449 457 2P9S 17499050 Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+ 2007-03-26 2007-05-29 Nolen, B.J.,Pollard, T.D. Insights into the Influence of Nucleotides on Actin Family Proteins from Seven Structures of Arp2/3 Complex. Mol.Cell 2007 26 449 457 2ED6 17409146 Crystal Structure of Envelope Protein VP28 from White Spot Syndrome Virus (WSSV) 2007-02-14 2007-06-05 Tang, X.,Wu, J.,Sivaraman, J.,Hew, C.L. Crystal structures of major envelope proteins VP26 and VP28 from white spot syndrome virus shed light on their evolutionary relationship J.Virol. 2007 81 6709 6717 2I4T 17223688 Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with Imm-A 2006-08-22 2007-06-05 Rinaldo-Matthis, A.,Wing, C.,Ghanem, M.,Deng, H.,Wu, P.,Gupta, A.,Tyler, P.C.,Evans, G.B.,Furneaux, R.H.,Almo, S.C.,Wang, C.C.,Schramm, V.L. Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues. Biochemistry 2007 46 659 668 2ISC 17223688 Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A 2006-10-17 2007-06-05 Rinaldo-Matthis, A.,Wing, C.,Ghanem, M.,Deng, H.,Wu, P.,Gupta, A.,Tyler, P.C.,Evans, G.B.,Furneaux, R.H.,Almo, S.C.,Wang, C.C.,Schramm, V.L. Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues Biochemistry 2007 46 659 668 2PDR 17510367 1.7 Angstrom Crystal Structure of the Photo-excited Blue-light Photoreceptor Vivid 2007-04-01 2007-06-05 Zoltowski, B.D.,Schwerdtfeger, C.,Widom, J.,Loros, J.J.,Bilwes, A.M.,Dunlap, J.C.,Crane, B.R. Conformational switching in the fungal light sensor Vivid Science 2007 316 1054 1057 2PDR 17510367 1.7 Angstrom Crystal Structure of the Photo-excited Blue-light Photoreceptor Vivid 2007-04-01 2007-06-05 Zoltowski, B.D.,Schwerdtfeger, C.,Widom, J.,Loros, J.J.,Bilwes, A.M.,Dunlap, J.C.,Crane, B.R. Conformational switching in the fungal light sensor Vivid Science 2007 316 1054 1057 2PDR 17510367 1.7 Angstrom Crystal Structure of the Photo-excited Blue-light Photoreceptor Vivid 2007-04-01 2007-06-05 Zoltowski, B.D.,Schwerdtfeger, C.,Widom, J.,Loros, J.J.,Bilwes, A.M.,Dunlap, J.C.,Crane, B.R. Conformational switching in the fungal light sensor Vivid Science 2007 316 1054 1057 2PDR 17510367 1.7 Angstrom Crystal Structure of the Photo-excited Blue-light Photoreceptor Vivid 2007-04-01 2007-06-05 Zoltowski, B.D.,Schwerdtfeger, C.,Widom, J.,Loros, J.J.,Bilwes, A.M.,Dunlap, J.C.,Crane, B.R. Conformational switching in the fungal light sensor Vivid Science 2007 316 1054 1057 2Q07 Crystal structure of AF0587, a protein of unknown function 2007-05-21 2007-06-05 Sugadev, R.,Burley, S.K.,Swaminathan, S. Crystal structure of AF0587, a protein of unknown function. To be Published 0 0 0 0 2OJR 17497863 Structure of ubiquitin solved by SAD using the Lanthanide-Binding Tag 2007-01-13 2007-06-12 Silvaggi, N.R.,Martin, L.J.,Schwalbe, H.,Imperiali, B.,Allen, K.N. Double-Lanthanide-Binding Tags for Macromolecular Crystallographic Structure Determination. J.Am.Chem.Soc. 2007 129 7114 7120 2OS5 17567581 Macrophage migration inhibitory factor from Ancylostoma ceylanicum 2007-02-05 2007-06-12 Cho, Y.,Jones, B.F.,Vermeire, J.J.,Leng, L.,DiFedele, L.,Harrison, L.M.,Xiong, H.,Kwong, Y.K.,Chen, Y.,Bucala, R.,Lolis, E.,Cappello, M. Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. J.Biol.Chem. 2007 282 23447 23456 2OS5 17567581 Macrophage migration inhibitory factor from Ancylostoma ceylanicum 2007-02-05 2007-06-12 Cho, Y.,Jones, B.F.,Vermeire, J.J.,Leng, L.,DiFedele, L.,Harrison, L.M.,Xiong, H.,Kwong, Y.K.,Chen, Y.,Bucala, R.,Lolis, E.,Cappello, M. Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. J.Biol.Chem. 2007 282 23447 23456 2HKA 17573352 Crystal structure of bovine NPC2 and cholesterol sulfate complex 2006-07-03 2007-06-26 Xu, S.,Benoff, B.,Liou, H.-L.,Lobel, P.,Stock, A.M. Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease J.Biol.Chem. 2007 282 23525 23531 2J0L 17574028 Crystal structure of a the active conformation of the kinase domain of focal adhesion kinase with a phosphorylated activation loop. 2006-08-03 2007-06-26 Lietha, D.,Cai, X.,Ceccarelli, D.F.J.,Li, Y.,Schaller, M.D.,Eck, M.J. Structural Basis for the Autoinhibition of Focal Adhesion Kinase Cell(Cambridge,Mass.) 2007 129 1177 0 2PKD 17563375 Crystal structure of CD84: Insite into SLAM family function 2007-04-17 2007-06-26 Yan, Q.,Malashkevich, V.N.,Fedorov, A.,Fedorov, E.,Cao, E.,Lary, J.W.,Cole, J.L.,Nathenson, S.G.,Almo, S.C. Structure of CD84 provides insight into SLAM family function. Proc.Natl.Acad.Sci.Usa 2007 104 10583 10588 2J0M 17574028 Crystal structure a two-chain complex between the FERM and kinase domains of focal adhesion kinase. 2006-08-03 2007-07-03 Lietha, D.,Cai, X.,Li, Y.,Schaller, M.D.,Eck, M.J. Structural Basis for the Autoinhibition of Focal Adhesion Kinase. Cell(Cambridge,Mass.) 2007 129 1177 0 2PJD 17576679 Crystal structure of 16S rRNA methyltransferase RsmC 2007-04-16 2007-07-03 Sunita, S.,Purta, E.,Durawa, M.,Tkaczuk, K.L.,Swaathi, J.,Bujnicki, J.M.,Sivaraman, J. Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC Nucleic Acids Res. 2007 35 4264 4274 2Q5C Crystal structure of NtrC family transcriptional regulator from Clostridium acetobutylicum 2007-05-31 2007-07-03 Ramagopal, U.A.,Dickey, M.,Toro, R.,Iizuka, M.,Groshong, K.,Rodgers, L.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of NtrC family transcriptional regulator from Clostridium acetobutylicum. To be Published 0 0 0 0 2QDE Crystal structure of mandelate racemase/muconate lactonizing family protein from Azoarcus sp. EbN1 2007-06-20 2007-07-03 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of mandelate racemase/muconate lactonizing enzyme family protein from Azoarcus sp. EbN1. To be Published 0 0 0 0 2HSE Structure of D236A E. coli Aspartate Transcarbamoylase in the presence of phosphonoacetamide and l-Aspartate at 2.60 A resolution 2006-07-21 2007-07-17 Wang, J.,Eldo, J.,Kantrowitz, E.R. The allosteric transition induced by the aspartate binding to Aspartate Transcarbamoylase To be Published 0 0 0 0 2QE3 19522538 Crystal structure of human tl1a extracellular domain 2007-06-22 2007-07-17 Zhan, C.,Yan, Q.,Patskovsky, Y.,Li, Z.,Toro, R.,Meyer, A.,Cheng, H.,Brenowitz, M.,Nathenson, S.G.,Almo, S.C. Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry 2009 48 7636 7645 2QF9 Crystal structure of putative secreted protein DUF305 from Streptomyces coelicolor 2007-06-27 2007-07-17 Ramagopal, U.A.,Rutter, M.,Adams, J.,Toro, R.,Groshong, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Structure of putative secreted protein DUF305 from Streptomyces coelicolor. To be Published 0 0 0 0 2QH0 Crystal structure of a glyoxalase from clostridium acetobutylicum 2007-06-29 2007-07-17 Rao, K.N.,Burley, S.K.,Swaminathan, S. Crystal structure of a glyoxalase from clostridium acetobutylicum. To be Published 0 0 0 0 2Q7G 17592110 Pyrrolysine tRNA Synthetase bound to a pyrrolysine analogue (cyc) and ATP 2007-06-06 2007-07-24 Kavran, J.M.,Gundllapalli, S.,O'donoghue, P.,Englert, M.,Soll, D.,Steitz, T.A. Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation. Proc.Natl.Acad.Sci.Usa 2007 104 11268 11273 2QGZ Crystal structure of a putative primosome component from Streptococcus pyogenes serotype M3. Northeast Structural Genomics target DR58 2007-06-29 2007-07-24 Seetharaman, J.,Chen, Y.,Wang, D.,Fang, Y.,Cunningham, K.,Ma, L.-C.,Xia, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of a putative primosome component from Streptococcus pyogenes serotype M3. To be Published 0 0 0 0 2QKP Crystal structure of C-terminal domain of SMU_1151c from Streptococcus mutans 2007-07-11 2007-07-24 Ramagopal, U.A.,Toro, R.,Gilmore, M.,Wu, B.,Bain, K.,Gheyi, T.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Structure of C-terminal domain of SMU_1151c from Streptococcus mutans. To be Published 0 0 0 0 2PQW 18026117 Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), trigonal form 2007-05-02 2007-07-31 Min, J.,Allali-Hassani, A.,Nady, N.,Qi, C.,Ouyang, H.,Liu, Y.,MacKenzie, F.,Vedadi, M.,Arrowsmith, C.H. L3MBTL1 recognition of mono- and dimethylated histones. Nat.Struct.Mol.Biol. 2007 14 1229 1230 2QGO Crystal structure of a putative Fe-S biosynthesis protein from Lactobacillus acidophilus 2007-06-29 2007-07-31 Agarwal, R.,Burley, S.K.,Swaminathan, S. Structural analysis of Fe-S cluster proteins. To be Published 0 0 0 0 2PLL 17562323 Crystal structure of perdeuterated human arginase I 2007-04-19 2007-08-14 Di Costanzo, L.,Moulin, M.,Haertlein, M.,Meilleur, F.,Christianson, D.W. Expression, purification, assay, and crystal structure of perdeuterated human arginase I Arch.Biochem.Biophys. 2007 465 82 89 2QR4 Crystal structure of oligoendopeptidase-F from Enterococcus faecium 2007-07-27 2007-08-14 Ramagopal, U.A.,Toro, R.,Meyer, A.J.,Freeman, J.,Bain, K.,Rodgers, L.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of oligoendopeptidase-F from Enterococcus faecium. To be Published 0 0 0 0 2P7V 17681541 Crystal structure of the Escherichia coli regulator of sigma 70, Rsd, in complex with sigma 70 domain 4 2007-03-20 2007-08-21 Patikoglou, G.A.,Westblade, L.F.,Campbell, E.A.,Lamour, V.,Lane, W.J.,Darst, S.A. Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4. J.Mol.Biol. 2007 372 649 659 2Q72 17687333 Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine 2007-06-05 2007-08-21 Singh, S.K.,Yamashita, A.,Gouaux, E. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 2007 448 952 956 2QAP 17661446 Fructose-1,6-bisphosphate aldolase from Leishmania mexicana 2007-06-15 2007-08-21 Lafrance-Vanasse, J.,Sygusch, J. Carboxy-Terminus Recruitment Induced by Substrate Binding in Eukaryotic Fructose Bis-phosphate Aldolases Biochemistry 2007 46 9533 9540 2QB4 17687333 Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine 2007-06-15 2007-08-21 Singh, S.K.,Yamashita, A.,Gouaux, E. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 2007 448 952 956 2QDG 17661446 Fructose-1,6-bisphosphate Schiff base intermediate in FBP aldolase from Leishmania mexicana 2007-06-20 2007-08-21 Lafrance-Vanasse, J.,Sygusch, J. Carboxy-Terminus Recruitment Induced by Substrate Binding in Eukaryotic Fructose Bis-phosphate Aldolases Biochemistry 2007 46 9533 9540 2QDH 17661446 Fructose-1,6-bisphosphate aldolase from Leishmania mexicana in complex with mannitol-1,6-bisphosphate, a competitive inhibitor 2007-06-20 2007-08-21 Lafrance-Vanasse, J.,Sygusch, J. Carboxy-Terminus Recruitment Induced by Substrate Binding in Eukaryotic Fructose Bis-phosphate Aldolases Biochemistry 2007 46 9533 9540 2QJU 17690258 Crystal Structure of an NSS Homolog with Bound Antidepressant 2007-07-09 2007-08-21 Zhou, Z.,Zhen, J.,Karpowich, N.K.,Goetz, R.M.,Law, C.J.,Reith, M.E.,Wang, D.N. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science 2007 317 1390 1393 2QS8 19358546 Crystal structure of a Xaa-Pro dipeptidase with bound methionine in the active site 2007-07-30 2007-08-21 Xiang, D.F.,Xu, C.,Kumaran, D.,Brown, A.C.,Sauder, J.M.,Burley, S.K.,Swaminathan, S.,Raushel, F.M. Functional annotation of two new carboxypeptidases from the amidohydrolase superfamily of enzymes. Biochemistry 2009 48 4567 4576 2Q66 17850751 Structure of Yeast Poly(A) Polymerase with ATP and oligo(A) 2007-06-04 2007-08-28 Balbo, P.B.,Bohm, A. Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis. Structure 2007 15 1117 1131 2QKS 17703190 Crystal structure of a Kir3.1-prokaryotic Kir channel chimera 2007-07-11 2007-08-28 Nishida, M.,Cadene, M.,Chait, B.T.,Mackinnon, R. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. Embo J. 2007 26 4005 4015 2QVC 23192024 Crystal structure of a periplasmic sugar ABC transporter from Thermotoga maritima 2007-08-08 2007-08-28 Palani, K.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Structure of a periplasmic glucose-binding protein from Thermotoga maritima. Acta Crystallogr.,Sect.F 2012 68 1460 1464 2QVG The crystal structure of a two-component response regulator from Legionella pneumophila 2007-08-08 2007-08-28 Tyagi, R.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. The crystal structure of a two-component response regulator from Legionella pneumophila. To be Published 0 0 0 0 2QVH Crystal structure of O-succinylbenzoate synthase complexed with O-succinyl benzoate (OSB) 2007-08-08 2007-08-28 Sugadev, R.,Burley, S.K.,Swaminathan, S. Crystal structure of O-succinylbenzoate synthase complexed with O-succinyl benzoate. To be Published 0 0 0 0 2QYZ Crystal structure of the uncharacterized protein CTC02137 from Clostridium tetani E88 2007-08-15 2007-08-28 Malashkevich, V.N.,Toro, R.,Meyer, A.J.,Sauder, J.M.,Wasserman, T.,Burley, S.K.,Almo, S.C. Crystal structure of the uncharacterized protein CTC02137 from Clostridium tetani E88. To be Published 0 0 0 0 2QZB Crystal structure of the uncharacterized protein yfeY from Escherichia coli 2007-08-16 2007-08-28 Bonanno, J.B.,Gilmore, M.,Bain, K.T.,Wu, B.,Romero, R.,Smith, D.,Wasserman, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of the uncharacterized protein yfeY from Escherichia coli. To be Published 0 0 0 0 2R5X Crystal structure of uncharacterized conserved protein YugN from Geobacillus kaustophilus HTA426 2007-09-04 2007-09-11 Ramagopal, U.A.,Patskovsky, Y.,Shi, W.,Toro, R.,Meyer, A.J.,Freeman, J.,Wu, B.,Koss, J.,Groshong, C.,Rodgers, L.,Wasserman, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of uncharacterized protein YugN from Geobacillus kaustophilus HTA426. To be Published 0 0 0 0 2O5N 17897947 Crystal structure of a Viral Glycoprotein 2006-12-06 2007-09-25 Mans, J.,Natarajan, K.,Balbo, A.,Schuck, P.,Eikel, D.,Hess, S.,Robinson, H.,Simic, H.,Jonjic, S.,Tiemessen, C.T.,Margulies, D.H. Cellular Expression and Crystal Structure of the Murine Cytomegalovirus Major Histocompatibility Complex Class I-like Glycoprotein, m153. J.Biol.Chem. 2007 282 35247 35258 2PWM 17826792 Crystal Structure of HIV-1 CA146 A92E real cell 2007-05-11 2007-09-25 Kelly, B.N.,Kyere, S.,Kinde, I.,Tang, C.,Howard, B.R.,Robinson, H.,Sundquist, W.I.,Summers, M.F.,Hill, C.P. Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol. 2007 373 355 366 2PWO 17826792 Crystal Structure of HIV-1 CA146 A92E Psuedo Cell 2007-05-11 2007-09-25 Kelly, B.N.,Kyere, S.,Kinde, I.,Tang, C.,Howard, B.R.,Robinson, H.,Sundquist, W.I.,Summers, M.F.,Hill, C.P. Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol. 2007 373 355 366 2QHO 17897937 Crystal structure of the UBA domain from EDD ubiquitin ligase in complex with ubiquitin 2007-07-02 2007-09-25 Kozlov, G.,Nguyen, L.,Lin, T.,De Crescenzo, G.,Park, M.,Gehring, K. Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD. J.Biol.Chem. 2007 282 35787 35795 2QLV 17851534 Crystal structure of the heterotrimer core of the S. cerevisiae AMPK homolog SNF1 2007-07-13 2007-09-25 Amodeo, G.A.,Rudolph, M.J.,Tong, L. Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature 2007 449 492 495 2OPN Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527 2007-01-29 2007-10-02 Zhang, Y.,Cao, R.,Leon, A.,Guo, R.T.,Krysiak, K.,Yin, F.,Hudock, M.P.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Hong, W.,Morita, C.,Wang, A.H.-J.,Oldfield, E. Bisphosphonates: Teaching Old Drugs with New Tricks To be Published 0 0 0 0 2QL6 17698003 human nicotinamide riboside kinase (NRK1) 2007-07-12 2007-10-02 Khan, J.A.,Xiang, S.,Tong, L. Crystal structure of human nicotinamide riboside kinase Structure 2007 15 1005 1013 2R9G Crystal structure of the C-terminal fragment of AAA ATPase from Enterococcus faecium 2007-09-12 2007-10-02 Ramagopal, U.A.,Patskovsky, Y.,Bonanno, J.B.,Shi, W.,Toro, R.,Meyer, A.J.,Rutter, M.,Wu, B.,Groshong, C.,Gheyi, T.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of the C-Terminal Domain of AAA ATPase from Enterococcus faecium. To be Published 0 0 0 0 2RDM Crystal structure of response regulator receiver protein from Sinorhizobium medicae WSM419 2007-09-24 2007-10-09 Patskovsky, Y.,Yan, Q.,Zhan, C.,Toro, R.,Meyer, A.J.,Gilmore, M.,Hu, S.,Groshong, C.,Rodgers, L.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of response regulator receiver protein from Sinorhizobium medicae WSM419. To be Published 0 0 0 0 2QHD 18586854 Crystal structure of ecarpholin S (ser49-PLA2) complexed with fatty acid 2007-07-02 2007-10-16 Zhou, X.,Tan, T.C.,Valiyaveettil, S.,Go, M.L.,Kini, R.M.,Velazquez-Campoy, A.,Sivaraman, J. Structural Characterization of Myotoxic Ecarpholin S from Echis carinatus Venom Biophys.J. 2008 95 3366 3380 2RBB Crystal structure of a glyoxalase/bleomycin resistance protein/dioxygenase family enzyme from Burkholderia phytofirmans PsJN 2007-09-18 2007-10-16 Rao, K.N.,Sauder, J.M.,Burley, S.K.,Swaminathan, S. Crystal structure of a glyoxalase/bleomycin resistance protein/dioxygenase family enzyme from Burkholderia phytofirmans PsJN. To be Published 0 0 0 0 2PW3 17582435 Structure of the PDE4D-cAMP complex 2007-05-10 2007-10-23 Wang, H.,Robinson, H.,Ke, H. The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. J.Mol.Biol. 2007 371 302 307 2RG4 Crystal structure of the uncharacterized protein Q2CBJ1_9RHOB from Oceanicola granulosus HTCC2516 2007-10-02 2007-10-23 Malashkevich, V.N.,Toro, R.,Meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of the uncharacterized protein Q2CBJ1_9RHOB from Oceanicola granulosus HTCC2516. To be Published 0 0 0 0 2RGY Crystal structure of transcriptional regulator of LacI family from Burkhoderia phymatum 2007-10-05 2007-10-23 Agarwal, R.,Burley, S.K.,Swaminathan, S. Structural analysis of transcription regulator of LacI family from Burkholderia phymatum. To be Published 0 0 0 0 2RJN Crystal structure of an uncharacterized protein Q2BKU2 from Neptuniibacter caesariensis 2007-10-15 2007-10-23 Malashkevich, V.N.,Toro, R.,Meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of an uncharacterized protein Q2BKU2 from Neptuniibacter caesariensis. To be Published 0 0 0 0 2RJO Crystal structure of Twin-arginine translocation pathway signal protein from Burkholderia phytofirmans 2007-10-15 2007-10-23 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of twin-arginine translocation pathway signal protein from Burkholderia phytofirmans. To be Published 0 0 0 0 2RK0 Crystal structure of glyoxylase/bleomycin resistance protein/dioxygenase domain from Frankia sp. EAN1pec 2007-10-16 2007-10-30 Sugadev, R.,Burley, S.K.,Swaminathan, S. Crystal structure of glyoxylase/bleomycin resistance protein/dioxygenase domain from Frankia sp. EAN1pec. To be Published 0 0 0 0 2RK9 The crystal structure of a glyoxalase/bleomycin resistance protein/dioxygenase superfamily member from Vibrio splendidus 12B01 2007-10-16 2007-10-30 Tyagi, R.,Eswaramoorthy, S.,Sauder, J.M.,Burley, S.K.,Swaminathan, S. The crystal structure of a glyoxalase/bleomycin resistance protein/dioxygenase superfamily member from Vibrio splendidus 12B01. To be Published 0 0 0 0 3B2N Crystal structure of DNA-binding response regulator, LuxR family, from Staphylococcus aureus 2007-10-18 2007-10-30 Malashkevich, V.N.,Toro, R.,Meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of DNA-binding response regulator, LuxR family, from Staphylococcus aureus. To be Published 0 0 0 0 2Q1M 18040044 Crystal Structure of human GITRL 2007-05-24 2007-11-13 Chattopadhyay, K.,Ramagopal, U.A.,Mukhopadhaya, A.,Malashkevich, V.N.,Dilorenzo, T.P.,Brenowitz, M.,Nathenson, S.G.,Almo, S.C. Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function. Proc.Natl.Acad.Sci.USA 2007 104 19452 19457 2PJO 17986339 Ricin a-chain (recombinant) complex with n-methylurea 2007-04-16 2007-11-20 Carra, J.H.,McHugh, C.A.,Mulligan, S.,Machiesky, L.M.,Soares, A.S.,Millard, C.B. Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site. Bmc Struct.Biol. 2007 7 72 72 2PTT 17950006 Structure of NK cell receptor 2B4 (CD244) bound to its ligand CD48 2007-05-08 2007-11-20 Velikovsky, C.A.,Deng, L.,Chlewicki, L.K.,Fernandez, M.M.,Kumar, V.,Mariuzza, R.A. Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family. Immunity 2007 27 572 584 2PTU 17950006 Structure of NK cell receptor 2B4 (CD244) 2007-05-08 2007-11-20 Velikovsky, C.A.,Deng, L.,Chlewicki, L.K.,Fernandez, M.M.,Kumar, V.,Mariuzza, R.A. Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family. Immunity 2007 27 572 584 2PTV 17950006 Structure of NK cell receptor ligand CD48 2007-05-08 2007-11-20 Velikovsky, C.A.,Deng, L.,Chlewicki, L.K.,Fernandez, M.M.,Kumar, V.,Mariuzza, R.A. Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family. Immunity 2007 27 572 584 2R32 18040044 Crystal Structure of human GITRL variant 2007-08-28 2007-11-20 Chattopadhyay, K.,Ramagopal, U.A.,Mukhopadhaya, A.,Malashkevich, V.N.,Dilorenzo, T.P.,Brenowitz, M.,Nathenson, S.G.,Almo, S.C. Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function. Proc.Natl.Acad.Sci.USA 2007 104 19452 19457 2R9H Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab 2007-09-12 2007-11-20 Miller, C.,Nguitragool, W. Crystal Structure of Q207C Mutant of CLC-ec1 in complex with Fab To be Published 0 0 0 0 2R9R 18004376 Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit 2007-09-13 2007-11-20 Long, S.B.,Tao, X.,Campbell, E.B.,MacKinnon, R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature 2007 450 376 382 2RB8 17971437 High resolution design of a protein loop 2007-09-18 2007-11-20 Hu, X.,Wang, H.,Ke, H.,Kuhlman, B. High-resolution design of a protein loop. Proc.Natl.Acad.Sci.Usa 2007 104 17668 17673 3B89 Crystal structure of rRNA methylase from Escherichia coli 2007-10-31 2007-11-27 Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of rRNA methylase from Escherichia coli. To be Published 0 0 0 0 3BBL Crystal structure of a regulatory protein of LacI family from Chloroflexus aggregans 2007-11-09 2007-11-27 Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a regulatory protein of LacI family from the Chloroflexus aggregans. To be Published 0 0 0 0 3BCV Crystal structure of a putative glycosyltransferase from Bacteroides fragilis 2007-11-13 2007-11-27 Palani, K.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative glycosyltransferase from Bacteroides fragilis. To be Published 0 0 0 0 3BE7 19281183 Crystal structure of Zn-dependent arginine carboxypeptidase 2007-11-16 2007-11-27 Xiang, D.F.,Patskovsky, Y.,Xu, C.,Meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Raushel, F.M. Functional identification of incorrectly annotated prolidases from the amidohydrolase superfamily of enzymes. Biochemistry 2009 48 3730 3742 2QLR 18056995 Crystal structure of human kynurenine aminotransferase II 2007-07-13 2007-12-04 Han, Q.,Robinson, H.,Li, J. Crystal Structure of Human Kynurenine Aminotransferase II J.Biol.Chem. 2008 283 3567 3573 2R0D 18042453 Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor 2007-08-18 2007-12-04 DiNitto, J.P.,Delprato, A.,Gabe Lee, M.T.,Cronin, T.C.,Huang, S.,Guilherme, A.,Czech, M.P.,Lambright, D.G. Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors. Mol.Cell 2007 28 569 583 2R2N 18056995 The crystal structure of human kynurenine aminotransferase II in complex with kynurenine 2007-08-27 2007-12-04 Han, Q.,Robinson, H.,Li, J. Crystal structure of human kynurenine aminotransferase II. J.Biol.Chem. 2008 283 3567 3573 3BCH 18063583 Crystal Structure of the Human Laminin Receptor Precursor 2007-11-12 2007-12-04 Jamieson, K.V.,Wu, J.,Hubbard, S.R.,Meruelo, D. Crystal structure of the human laminin receptor precursor. J.Biol.Chem. 2008 283 3002 3005 2OPM 19309137 Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 2007-01-29 2007-12-11 Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.K.,Lin, F.Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc. 2009 131 5153 5162 3BGA Crystal structure of beta-galactosidase from Bacteroides thetaiotaomicron VPI-5482 2007-11-26 2007-12-11 Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure analysis of beta-galactosidase from Bacteroides thetaiotaomicron VPI-5482. To be Published 0 0 0 0 2O5F 18512963 Crystal Structure of DR0079 from Deinococcus radiodurans at 1.9 Angstrom Resolution 2006-12-05 2007-12-18 Buchko, G.W.,Litvinova, O.,Robinson, H.,Yakunin, A.F.,Kennedy, M.A. Functional and Structural Characterization of DR_0079 from Deinococcus radiodurans, a Novel Nudix Hydrolase with a Preference for Cytosine (Deoxy)ribonucleoside 5'-Di- and Triphosphates. Biochemistry 2008 47 6571 6582 2O5F 18512963 Crystal Structure of DR0079 from Deinococcus radiodurans at 1.9 Angstrom Resolution 2006-12-05 2007-12-18 Buchko, G.W.,Litvinova, O.,Robinson, H.,Yakunin, A.F.,Kennedy, M.A. Functional and Structural Characterization of DR_0079 from Deinococcus radiodurans, a Novel Nudix Hydrolase with a Preference for Cytosine (Deoxy)ribonucleoside 5'-Di- and Triphosphates. Biochemistry 2008 47 6571 6582 2O6W 18158251 Crystal Structure of a Pentapeptide Repeat Protein (Rfr23) from the cyanobacterium Cyanothece 51142 2006-12-08 2007-12-18 Buchko, G.W.,Robinson, H.,Pakrasi, H.B.,Kennedy, M.A. Insights into the structural variation between pentapeptide repeat proteins-Crystal structure of Rfr23 from Cyanothece 51142. J.Struct.Biol. 2008 162 184 192 2OFM 17660249 1.11 A Crystal Structure of Apo Nitrophorin 4 From Rhodnius Prolixus 2007-01-03 2007-12-18 Amoia, A.M.,Montfort, W.R. Apo-nitrophorin 4 at atomic resolution. Protein Sci. 2007 16 2076 2081 2QUD 18066080 PP7 Coat Protein Dimer 2007-08-04 2007-12-18 Chao, J.A.,Patskovsky, Y.,Almo, S.C.,Singer, R.H. Structural basis for the coevolution of a viral RNA-protein complex. Nat.Struct.Mol.Biol. 2008 15 103 105 2R8Q 17944832 Structure of LmjPDEB1 in complex with IBMX 2007-09-11 2007-12-18 Wang, H.,Yan, Z.,Geng, J.,Kunz, S.,Seebeck, T.,Ke, H. Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Mol.Microbiol. 2007 66 1029 1038 2RD0 18079394 Structure of a human p110alpha/p85alpha complex 2007-09-20 2007-12-25 Huang, C.H.,Mandelker, D.,Schmidt-Kittler, O.,Samuels, Y.,Velculescu, V.E.,Kinzler, K.W.,Vogelstein, B.,Gabelli, S.B.,Amzel, L.M. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 2007 318 1744 1748 3BGE Crystal structure of the C-terminal fragment of AAA+ATPase from Haemophilus influenzae 2007-11-26 2008-01-01 Ramagopal, U.A.,Patskovsky, Y.,Bonanno, J.B.,Meyer, A.J.,Toro, R.,Freeman, J.,Adams, J.,Koss, J.,Maletic, M.,Gheyi, T.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of the C-terminal fragment of AAA+ATPase from Haemophilus influenzae. To be Published 0 0 0 0 3BGS 18154341 Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate 2007-11-27 2008-01-08 Rinaldo-Matthis, A.,Murkin, A.S.,Ramagopal, U.A.,Clinch, K.,Mee, S.P.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. 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The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol. 2007 374 1104 1113 3B45 17976648 Crystal structure of GlpG at 1.9A resolution 2007-10-23 2008-01-22 Wang, Y.,Maegawa, S.,Akiyama, Y.,Ha, Y. The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol. 2007 374 1104 1113 3B8M 18204465 Structure of FepE- Bacterial Polysaccharide Co-polymerase 2007-11-01 2008-01-22 Tocilj, A.,Munger, C.,Proteau, A.,Morona, R.,Purins, L.,Ajamian, E.,Wagner, J.,Papadopoulos, M.,Van Den Bosch, L.,Rubinstein, J.L.,Fethiere, J.,Matte, A.,Cygler, M. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length Nat.Struct.Mol.Biol. 2008 15 130 138 3B8N 18204465 Structure of FepE- Bacterial Polysaccharide Co-polymerase 2007-11-01 2008-01-22 Tocilj, A.,Munger, C.,Proteau, A.,Morona, R.,Purins, L.,Ajamian, E.,Wagner, J.,Papadopoulos, M.,Van Den Bosch, L.,Rubinstein, J.L.,Fethiere, J.,Matte, A.,Cygler, M. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length Nat.Struct.Mol.Biol. 2008 15 130 138 3B8O 18204465 Structure of WzzE- Bacterial Polysaccharide Co-polymerase 2007-11-01 2008-01-22 Tocilj, A.,Munger, C.,Proteau, A.,Morona, R.,Purins, L.,Ajamian, E.,Wagner, J.,Papadopoulos, M.,Van Den Bosch, L.,Rubinstein, J.L.,Fethiere, J.,Matte, A.,Cygler, M. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length Nat.Struct.Mol.Biol. 2008 15 130 138 3B8P 18204465 Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium 2007-11-01 2008-01-22 Tocilj, A.,Munger, C.,Proteau, A.,Morona, R.,Purins, L.,Ajamian, E.,Wagner, J.,Papadopoulos, M.,Van Den Bosch, L.,Rubinstein, J.L.,Fethiere, J.,Matte, A.,Cygler, M. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length Nat.Struct.Mol.Biol. 2008 15 130 138 3BOB 18322527 Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 2 2007-12-17 2008-01-22 Xu, Y.,Feng, L.,Jeffrey, P.D.,Shi, Y.,Morel, F.M. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature 2008 452 56 61 3BOE 18322527 Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 2 with acetate (CDCA1-R2) 2007-12-17 2008-01-22 Xu, Y.,Feng, L.,Jeffrey, P.D.,Shi, Y.,Morel, F.M. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature 2008 452 56 61 3BOJ 18322527 Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 1 without bound metal (CDCA1-R1) 2007-12-17 2008-01-22 Xu, Y.,Feng, L.,Jeffrey, P.D.,Shi, Y.,Morel, F.M. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature 2008 452 56 61 3B6W 18216201 Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution 2007-10-29 2008-02-05 Zhang, W.,Cho, Y.,Lolis, E.,Howe, J.R. Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci. 2008 28 932 943 3BLX 18256028 Yeast Isocitrate Dehydrogenase (Apo Form) 2007-12-11 2008-02-05 Taylor, A.B.,Hu, G.,Hart, P.J.,McAlister-Henn, L. Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase. J.Biol.Chem. 2008 283 10872 10880 3BZW Crystal structure of a putative lipase from Bacteroides thetaiotaomicron 2008-01-18 2008-02-05 Palani, K.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative lipase from Bacteroides thetaiotaomicron. To be Published 0 0 0 0 3C3K Crystal structure of an uncharacterized protein from Actinobacillus succinogenes 2008-01-28 2008-02-05 Malashkevich, V.N.,Toro, R.,Meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of an uncharacterized protein from Actinobacillus succinogenes. To be Published 0 0 0 0 3C3M Crystal structure of the N-terminal domain of response regulator receiver protein from Methanoculleus marisnigri JR1 2008-01-28 2008-02-05 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Meyer, A.J.,Dickey, M.,Chang, S.,Groshong, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of the N-terminal domain of response regulator receiver protein from Methanoculleus marisnigri JR1. To be Published 0 0 0 0 2RF3 18253536 Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles 2007-09-27 2008-02-12 Pallan, P.S.,Ittig, D.,Heroux, A.,Wawrzak, Z.,Leumann, C.J.,Egli, M. Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles. Chem.Commun.(Camb.) 2008 2008 883 885 3BEO 18188181 A Structural Basis for the allosteric regulation of non-hydrolyzing UDP-GlcNAc 2-epimerases 2007-11-19 2008-02-19 Velloso, L.M.,Bhaskaran, S.S.,Schuch, R.,Fischetti, V.A.,Stebbins, C.E. A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases. Embo Rep. 2008 9 199 205 3C5K Crystal structure of human HDAC6 zinc finger domain 2008-01-31 2008-02-19 Dong, A.,Ravichandran, M.,Schuetz, A.,Loppnau, P.,Li, Y.,MacKenzie, F.,Kozieradzki, I.,Edwards, A.M.,Arrowsmith, C.H.,Weigelt, J.,Bountra, C.,Bochkarev, A.,Dhe-Paganon, S.,Min, J.,Ouyang, H. Crystal Structure of Human HDAC6 zinc finger domain. To be Published 0 0 0 0 3B2T 18056630 Structure of phosphotransferase 2007-10-19 2008-02-26 Lew, E.D.,Bae, J.H.,Rohmann, E.,Wollnik, B.,Schlessinger, J. Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation. Proc.Natl.Acad.Sci.Usa 2007 104 19802 19807 3BG3 18297087 Crystal Structure of Human Pyruvate Carboxylase (missing the biotin carboxylase domain at the N-terminus) 2007-11-26 2008-02-26 Xiang, S.,Tong, L. Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat.Struct.Mol.Biol. 2008 15 295 302 3BUM 18273061 Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 2008-01-03 2008-02-26 Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J. 2008 27 804 816 3BUN 18273061 Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 2008-01-03 2008-02-26 Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J. 2008 27 804 816 3BUO 18273061 Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor' 2008-01-03 2008-02-26 Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J. 2008 27 804 816 3BUW 18273061 Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk 2008-01-03 2008-02-26 Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J. 2008 27 804 816 3BUX 18273061 Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met 2008-01-03 2008-02-26 Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J. 2008 27 804 816 2VOF 18462686 Structure of mouse A1 bound to the Puma BH3-domain 2008-02-17 2008-03-04 Smits, C.,Czabotar, P.E.,Hinds, M.G.,Day, C.L. Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1. Structure 2008 16 818 0 3BTS 18292341 Crystal structure of a ternary complex of the transcriptional repressor Gal80p (Gal80S0 [G301R]) and the acidic activation domain of Gal4p (aa 854-874) from Saccharomyces cerevisiae with NAD 2007-12-30 2008-03-04 Kumar, P.R.,Yu, Y.,Sternglanz, R.,Johnston, S.A.,Joshua-Tor, L. NADP regulates the yeast GAL induction system. Science 2008 319 1090 1092 2QCY 18305031 Crystal Structure of a monomeric form of Severe Acute Respiratory Syndrome (SARS) 3C-like protease mutant 2007-06-20 2008-03-11 Shi, J.,Sivaraman, J.,Song, J. Mechanism for controlling the dimer-monomer switch and coupling dimerization to catalysis of the severe acute respiratory syndrome coronavirus 3C-like protease. J.Virol. 2008 82 4620 4629 2R5C 18186649 Aedes Kynurenine Aminotransferase in Complex with Cysteine 2007-09-03 2008-03-18 Han, Q.,Gao, Y.G.,Robinson, H.,Li, J. Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase. Biochemistry 2008 47 1622 1630 2R5E 18186649 Aedes kynurenine aminotransferase in complex with glutamine 2007-09-03 2008-03-18 Han, Q.,Gao, Y.G.,Robinson, H.,Li, J. Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase. Biochemistry 2008 47 1622 1630 3CAX Crystal structure of uncharacterized protein PF0695 2008-02-20 2008-03-18 Ramagopal, U.A.,Hu, S.,Toro, R.,Gilmore, M.,Bain, K.,Meyer, A.J.,Rodgers, L.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of uncharacterized protein PF0695. To be Published 0 0 0 0 3CJP Crystal structure of an uncharacterized amidohydrolase CAC3332 from Clostridium acetobutylicum 2008-03-13 2008-03-25 Malashkevich, V.N.,Toro, R.,Ramagopal, U.A.,Bonanno, J.B.,Meyer, A.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of an uncharacterized amidohydrolase CAC3332 from Clostridium acetobutylicum. To be Published 0 0 0 0 3CK5 Crystal structure of a racemase from Streptomyces coelicolor A3(2) with bound magnesium 2008-03-14 2008-03-25 Rao, K.N.,Burley, S.K.,Swaminathan, S. Crystal structure of a racemase from Streptomyces coelicolor A3(2) with bound magnesium. To be Published 0 0 0 0 2QY2 18400173 Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domainm. 2007-08-13 2008-04-01 Benarroch, D.,Smith, P.,Shuman, S. Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain. Structure 2008 16 501 512 3BGY Triclinic structure of Mimivirus Capping Enzyme Triphosphatase at 1.65 A 2007-11-27 2008-04-01 Benarroch, D.,Smith, P.,Shuman, S. Triclinic structure of Mimivirus Capping Enzyme Triphosphatase at 1.65 A To be Published 0 0 0 0 3BUV 18407998 Crystal structure of human Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and HEPES. Resolution: 1.35 A. 2008-01-03 2008-04-01 Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem. 2008 283 16830 16839 3CIH Crystal structure of a putative alpha-rhamnosidase from Bacteroides thetaiotaomicron 2008-03-11 2008-04-01 Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative alpha-rhamnosidase from Bacteroides thetaiotaomicron. To be Published 0 0 0 0 2QYK 17727341 Crystal structure of PDE4A10 in complex with inhibitor NPV 2007-08-15 2008-04-08 Wang, H.,Peng, M.S.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M.D.,Cai, J.,Ke, H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J. 2007 408 193 201 2QYL 17727341 Crystal structure of PDE4B2B in complex with inhibitor NPV 2007-08-15 2008-04-08 Wang, H.,Peng, M.S.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M.D.,Cai, J.,Ke, H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J. 2007 408 193 201 2QYM 17727341 crystal structure of unliganded PDE4C2 2007-08-15 2008-04-08 Wang, H.,Peng, M.S.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M.D.,Cai, J.,Ke, H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J. 2007 408 193 201 2QYN 17727341 Crystal structure of PDE4D2 in complex with inhibitor NPV 2007-08-15 2008-04-08 Wang, H.,Peng, M.S.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M.D.,Cai, J.,Ke, H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J. 2007 408 193 201 3BQ1 18374650 Insertion ternary complex of Dbh DNA polymerase 2007-12-19 2008-04-08 Wilson, R.C.,Pata, J.D. Structural insights into the generation of single-base deletions by the Y family DNA polymerase dbh. Mol.Cell 2008 29 767 779 3BZC 18321528 Crystal Structure of the Tex protein from Pseudomonas aeruginosa, crystal form I 2008-01-17 2008-04-08 Johnson, S.J.,Close, D.,Robinson, H.,Vallet-Gely, I.,Dove, S.L.,Hill, C.P. Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa. J.Mol.Biol. 2008 377 1460 1473 3CO4 Crystal structure of a chitinase from Bacteroides thetaiotaomicron 2008-03-27 2008-04-08 Damodharan, L.,Burley, S.K.,Swaminathan, S. Crystal structure of a chitinase from Bacteroides thetaiotaomicron. To be Published 0 0 0 0 3COT 18407998 Crystal structure of human liver delta(4)-3-ketosteroid 5beta-reductase (akr1d1) in complex with progesterone and nadp. Resolution: 2.03 A. 2008-03-29 2008-04-08 Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem. 2008 283 16830 16839 3C5W 18394995 Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme 2008-02-01 2008-04-15 Xing, Y.,Li, Z.,Chen, Y.,Stock, J.B.,Jeffrey, P.D.,Shi, Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell(Cambridge,Mass.) 2008 133 154 163 3C5W 18394995 Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme 2008-02-01 2008-04-15 Xing, Y.,Li, Z.,Chen, Y.,Stock, J.B.,Jeffrey, P.D.,Shi, Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell(Cambridge,Mass.) 2008 133 154 163 3C8J 18426793 The crystal structure of natural killer cell receptor Ly49C 2008-02-12 2008-04-15 Deng, L.,Cho, S.,Malchiodi, E.L.,Kerzic, M.C.,Dam, J.,Mariuzza, R.A. Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors. J.Biol.Chem. 2008 283 16840 16849 3BJM 18227430 Crystal structure of human DPP-IV in complex with (1S,3S, 5S)-2-[(2S)-2-AMINO-2-(3-HYDROXYTRICYCLO[3.3.1.13,7]DEC-1- YL)ACETYL]-2-AZABICYCLO[3.1.0]HEXANE-3-CARBONITRILE (CAS), (1S,3S,5S)-2-((2S)-2-AMINO-2-(3-HYDROXYADAMANTAN-1- YL)ACETYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBONITRILE (IUPAC), OR BMS-477118 2007-12-04 2008-04-22 Metzler, W.J.,Yanchunas, J.,Weigelt, C.,Kish, K.,Klei, H.E.,Xie, D.,Zhang, Y.,Corbett, M.,Tamura, J.K.,He, B.,Hamann, L.G.,Kirby, M.S.,Marcinkeviciene, J. Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation. Protein Sci. 2008 17 240 250 3BWI 18434312 Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with an acetate ion bound at the active site 2008-01-09 2008-04-22 Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S. Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A J.Biol.Chem. 2008 283 18883 18891 3C88 18434312 Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with inhibitory peptide RRGC 2008-02-11 2008-04-22 Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S. Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A J.Biol.Chem. 2008 283 18883 18891 3C89 18434312 Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with inhibitory peptide RRGM 2008-02-11 2008-04-22 Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S. Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A J.Biol.Chem. 2008 283 18883 18891 3C8A 18434312 Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with inhibitory peptide RRGL 2008-02-11 2008-04-22 Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S. Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A J.Biol.Chem. 2008 283 18883 18891 3C8B 18434312 Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with inhibitory peptide RRGI 2008-02-11 2008-04-22 Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S. Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A J.Biol.Chem. 2008 283 18883 18891 2R19 18534617 Crystal structure of the periplasmic lipopolysaccharide transport protein LptA (YhbN), orthorhombic form 2007-08-22 2008-04-29 Suits, M.D.,Sperandeo, P.,Deho, G.,Polissi, A.,Jia, Z. Novel structure of the conserved gram-negative lipopolysaccharide transport protein A and mutagenesis analysis. J.Mol.Biol. 2008 380 476 488 2R19 18534617 Crystal structure of the periplasmic lipopolysaccharide transport protein LptA (YhbN), orthorhombic form 2007-08-22 2008-04-29 Suits, M.D.,Sperandeo, P.,Deho, G.,Polissi, A.,Jia, Z. Novel structure of the conserved gram-negative lipopolysaccharide transport protein A and mutagenesis analysis. J.Mol.Biol. 2008 380 476 488 3BJC 18346713 Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor 2007-12-03 2008-04-29 Chen, G.,Wang, H.,Robinson, H.,Cai, J.,Wan, Y.,Ke, H. An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies BIOCHEM.PHARM. 2008 75 1717 1728 3CMG Crystal structure of putative beta-galactosidase from Bacteroides fragilis 2008-03-21 2008-04-29 Ramagopal, U.A.,Rutter, M.,Toro, R.,Hu, S.,Maletic, M.,Gheyi, T.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative beta-galactosidase from Bacteroides fragilis. To be published 0 0 0 0 3CXJ Crystal structure of an uncharacterized protein from Methanothermobacter thermautotrophicus 2008-04-24 2008-05-13 Sugadev, R.,Burley, S.K.,Swaminathan, S. Crystal structure of an uncharacterized protein from Methanothermobacter thermautotrophicus. To be Published 0 0 0 0 3CYG Crystal structure of an uncharacterized protein from Fervidobacterium nodosum Rt17-B1 2008-04-25 2008-05-13 Damodharan, L.,Burley, S.K.,Swaminathan, S. Crystal structure of an uncharacterized protein from Fervidobacterium nodosum Rt17-B1. To be Published 0 0 0 0 3D0C Crystal structure of dihydrodipicolinate synthase from Oceanobacillus iheyensis at 1.9 A resolution 2008-05-01 2008-05-13 Satyanarayana, L.,Eswaramoorthy, S.,Sauder, J.M.,Burley, S.K.,Swaminathan, S. Crystal structure of dihydrodipicolinate synthase from Oceanobacillus iheyensis at 1.9 A resolution. To be Published 0 0 0 0 2RGJ 18416536 Crystal structure of flavin-containing monooxygenase PhzS 2007-10-03 2008-05-20 Greenhagen, B.T.,Shi, K.,Robinson, H.,Gamage, S.,Bera, A.K.,Ladner, J.E.,Parsons, J.F. Crystal Structure of the Pyocyanin Biosynthetic Protein PhzS. Biochemistry 2008 47 5281 5289 3B2R 17959709 Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil 2007-10-19 2008-05-20 Wang, H.,Ye, M.,Robinson, H.,Francis, S.H.,Ke, H. Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Mol.Pharmacol. 2008 73 104 110 3C66 18537269 Yeast poly(A) polymerase in complex with Fip1 residues 80-105 2008-02-02 2008-05-20 Meinke, G.,Ezeokonkwo, C.,Balbo, P.,Stafford, W.,Moore, C.,Bohm, A. Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein. Biochemistry 2008 47 6859 6869 3CC4 18455733 Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit 2008-02-24 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CC7 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U 2008-02-25 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CCE 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A 2008-02-25 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CCJ 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2534U 2008-02-26 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CCL 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535C. Density for Anisomycin is visible but not included in model. 2008-02-26 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CCM 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2611U 2008-02-26 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CCQ 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488U 2008-02-26 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CCR 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model. 2008-02-26 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CCS 18455733 Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A 2008-02-26 2008-05-20 Blaha, G.,Gurel, G.,Schroeder, S.J.,Moore, P.B.,Steitz, T.A. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J.Mol.Biol. 2008 379 505 519 3CJT 18611379 Ribosomal protein L11 methyltransferase (PrmA) in complex with dimethylated ribosomal protein L11 2008-03-13 2008-05-20 Demirci, H.,Gregory, S.T.,Dahlberg, A.E.,Jogl, G. Multiple-Site Trimethylation of Ribosomal Protein L11 by the PrmA Methyltransferase. Structure 2008 16 1059 1066 3D3A Crystal structure of a beta-galactosidase from Bacteroides thetaiotaomicron 2008-05-09 2008-05-27 Palani, K.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a beta-galactosidase from Bacteroides thetaiotaomicron. To be Published 0 0 0 0 2Q1K 18662905 Cyrstal Structure of AscE from Aeromonas hydrophilla 2007-05-24 2008-06-03 Tan, Y.W.,Yu, H.B.,Leung, K.Y.,Sivaraman, J.,Mok, Y.K. Structure of AscE and induced burial regions in AscE and AscG upon formation of the chaperone needle-subunit complex of type III secretion system in Aeromonas hydrophila. Protein Sci. 2008 17 1748 1760 2REH 17994768 Mechanistic and Structural Analyses of the Roles of Arg409 and Asp402 in the Reaction of the Flavoprotein Nitroalkane Oxidase 2007-09-26 2008-06-03 Fitzpatrick, P.F.,Bozinovski, D.M.,Heroux, A.,Shaw, P.G.,Valley, M.P.,Orville, A.M. Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase. Biochemistry 2007 46 13800 13808 3B64 18523291 Macrophage Migration Inhibitory Factor (MIF) From /Leishmania Major 2007-10-27 2008-06-10 Kamir, D.,Zierow, S.,Leng, L.,Cho, Y.,Diaz, Y.,Griffith, J.,McDonald, C.,Merk, M.,Mitchell, R.A.,Trent, J.,Chen, Y.,Kwong, Y.K.,Xiong, H.,Vermeire, J.,Cappello, M.,McMahon-Pratt, D.,Walker, J.,Bernhagen, J.,Lolis, E.,Bucala, R. A leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses. J.Immunol. 2008 180 8250 8261 3BS0 18559855 Crystal structure of the P. putida toluene transporter TodX 2007-12-21 2008-06-10 Hearn, E.M.,Patel, D.R.,van den Berg, B. Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation. Proc.Natl.Acad.Sci.Usa 2008 105 8601 8606 3CSX 19336042 Structural characterization of a protein in the DUF683 family- crystal structure of cce_0567 from the cyanobacterium Cyanothece 51142. 2008-04-10 2008-06-10 Buchko, G.W.,Robinson, H.,Addlagatta, A. Structural characterization of the protein cce_0567 from Cyanothece 51142, a metalloprotein associated with nitrogen fixation in the DUF683 family. Biochim.Biophys.Acta 2009 1794 627 633 3D5L Crystal structure of regulatory protein RecX 2008-05-16 2008-06-10 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of DNA repair regulatory protein RecX. To be Published 0 0 0 0 2QTK 18611376 Crystal Structure of the outer membrane protein opdK from Pseudomonas aeruginosa 2007-08-02 2008-06-24 Biswas, S.,Mohammad, M.M.,Movileanu, L.,van den Berg, B. Crystal Structure of the Outer Membrane Protein OpdK from Pseudomonas aeruginosa. Structure 2008 16 1027 1035 2ZL1 18479705 MP1-p14 Scaffolding complex 2008-04-02 2008-06-24 Cui, Q.,Sulea, T.,Schrag, J.D.,Munger, C.,Hung, M.N.,Naim, M.,Cygler, M.,Purisima, E.O. Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex. J.Mol.Biol. 2008 379 787 802 3BV4 18453690 Crystal structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant 2008-01-04 2008-06-24 Sherawat, M.,Tolan, D.R.,Allen, K.N. Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant. Acta Crystallogr.,Sect.D 2008 64 543 550 3CPT 18479705 MP1-p14 Scaffolding complex 2008-04-01 2008-07-01 Cui, Q.,Sulea, T.,Schrag, J.D.,Munger, C.,Hung, M.N.,Naim, M.,Cygler, M.,Purisima, E.O. Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex. J.Mol.Biol. 2008 379 787 802 3D0U 18593706 Crystal Structure of Lysine Riboswitch Bound to Lysine 2008-05-02 2008-07-01 Garst, A.D.,Heroux, A.,Rambo, R.P.,Batey, R.T. Crystal structure of the lysine riboswitch regulatory mRNA element. J.Biol.Chem. 2008 283 22347 22351 3D3X 18658150 Crystal structure of botulinum neurotoxin serotype E catalytic domain in complex with SNAP-25 substrate peptide 2008-05-13 2008-07-08 Agarwal, R.,Swaminathan, S. SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E. J.Biol.Chem. 2008 283 25944 25951 3DJ8 18802628 Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I 2008-06-22 2008-07-08 Zakharian, T.Y.,Di Costanzo, L.,Christianson, D.W. Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I Org.Biomol.Chem. 2008 6 3240 3243 3BOV 18641123 Crystal structure of the receptor binding domain of mouse PD-L2 2007-12-17 2008-07-15 Lazar-Molnar, E.,Yan, Q.,Cao, E.,Ramagopal, U.,Nathenson, S.G.,Almo, S.C. Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proc.Natl.Acad.Sci.USA 2008 105 10483 10488 3BP5 18641123 Crystal structure of the mouse PD-1 and PD-L2 complex 2007-12-18 2008-07-15 Lazar-Molnar, E.,Yan, Q.,Cao, E.,Ramagopal, U.,Nathenson, S.G.,Almo, S.C. Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proc.Natl.Acad.Sci.Usa 2008 105 10483 10488 2Z6M 18991401 Crystal structure of Human Ferritin H8 as biotemplate for noble metal nanoparticle synthesis 2007-08-04 2008-07-22 Butts, C.A.,Swift, J.,Kang, S.G.,Di Costanzo, L.,Christianson, D.W.,Saven, J.G.,Dmochowski, I.J. Directing noble metal ion chemistry within a designed ferritin protein Biochemistry 2008 47 12729 12739 3DJE Crystal structure of the deglycating enzyme fructosamine oxidase from Aspergillus fumigatus (Amadoriase II) in complex with FSA 2008-06-23 2008-07-22 Collard, F.,Zhang, J.,Nemet, I.,Qanungo, K.R.,Monnier, V.M.,Yee, V.C. Crystal structure of the deglycating enzyme fructosamine oxidase (FAOX-II) To be Published 0 0 0 0 3DJE Crystal structure of the deglycating enzyme fructosamine oxidase from Aspergillus fumigatus (Amadoriase II) in complex with FSA 2008-06-23 2008-07-22 Collard, F.,Zhang, J.,Nemet, I.,Qanungo, K.R.,Monnier, V.M.,Yee, V.C. Crystal structure of the deglycating enzyme fructosamine oxidase (FAOX-II) To be Published 0 0 0 0 3DC1 18620547 Crystal structure of kynurenine aminotransferase II complex with alpha-ketoglutarate 2008-06-03 2008-07-29 Han, Q.,Cai, T.,Tagle, D.A.,Robinson, H.,Li, J. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II Biosci.Rep. 2008 28 205 215 3CL1 18619611 M. loti cyclic-nucleotide binding domain, cyclic-GMP bound 2008-03-18 2008-08-05 Altieri, S.L.,Clayton, G.M.,Silverman, W.R.,Olivares, A.O.,De La Cruz, E.M.,Thomas, L.R.,Morais-Cabral, J.H. Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. J.Mol.Biol. 2008 381 655 669 3CLP 18619611 M. loti cyclic-nucleotide binding domain mutant 2 2008-03-19 2008-08-05 Altieri, S.L.,Clayton, G.M.,Silverman, W.R.,Olivares, A.O.,De La Cruz, E.M.,Thomas, L.R.,Morais-Cabral, J.H. Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. J.Mol.Biol. 2008 381 655 669 3CMM 18662542 Crystal Structure of the Uba1-Ubiquitin Complex 2008-03-23 2008-08-05 Lee, I.,Schindelin, H. Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes. Cell(Cambridge,Mass.) 2008 134 268 278 3CO2 18619611 Mlotik1 ion channel cyclic-nucleotide binding domain mutant 2008-03-27 2008-08-05 Altieri, S.L.,Clayton, G.M.,Silverman, W.R.,Olivares, A.O.,De La Cruz, E.M.,Thomas, L.R.,Morais-Cabral, J.H. Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. J.Mol.Biol. 2008 381 655 669 3DUG 19281183 Crystal structure of zn-dependent arginine carboxypeptidase complexed with zinc 2008-07-17 2008-08-05 Xiang, D.F.,Patskovsky, Y.,Xu, C.,Meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Raushel, F.M. Functional identification of incorrectly annotated prolidases from the amidohydrolase superfamily of enzymes. Biochemistry 2009 48 3730 3742 2QVI Crystal structure of N-cadherin domains EC12 2007-08-08 2008-08-12 Shapiro, L.S.,Carroll, K.J.,Honig, B. Biophysical characterization of N-cadherin and E-cadherin homophilic and heterophilic interactions To be Published 0 0 0 0 3E05 CRYSTAL STRUCTURE OF Precorrin-6y C5,15-methyltransferase FROM Geobacter metallireducens GS-15 2008-07-30 2008-08-12 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Dickey, M.,Hu, S.,Maletic, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF Precorrin-6y C5,15-methyltransferase from Geobacter metallireducens To be Published 0 0 0 0 3E18 CRYSTAL STRUCTURE OF NAD-BINDING PROTEIN FROM Listeria innocua 2008-08-02 2008-08-12 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Rutter, M.,Hu, S.,Groshong, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF NAD-BINDING PROTEIN FROM Listeria innocua To be Published 0 0 0 0 3DL5 18672899 Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis 2008-06-26 2008-08-19 Martucci, W.E.,Vargo, M.A.,Anderson, K.S. Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase. Biochemistry 2008 47 8902 8911 2RJK 19522538 Crystal Structure of Human TL1A Extracellular Domain C95S Mutant 2007-10-15 2008-08-26 Zhan, C.,Yan, Q.,Patskovsky, Y.,Li, Z.,Toro, R.,Meyer, A.,Cheng, H.,Brenowitz, M.,Nathenson, S.G.,Almo, S.C. Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry 2009 48 7636 7645 2RJL 19522538 Crystal structure of human TL1A extracellular domain C95S/C135S mutant 2007-10-15 2008-08-26 Zhan, C.,Yan, Q.,Patskovsky, Y.,Li, Z.,Toro, R.,Meyer, A.,Cheng, H.,Brenowitz, M.,Nathenson, S.G.,Almo, S.C. Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry 2009 48 7636 7645 3C52 18688832 Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with phosphoglycolohydroxamic acid, a competitive inhibitor 2008-01-30 2008-08-26 Fonvielle, M.,Coincon, M.,Daher, R.,Desbenoit, N.,Kosieradzka, K.,Barilone, N.,Gicquel, B.,Sygusch, J.,Jackson, M.,Therisod, M. Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics. Chemistry 2008 14 8521 8529 3C56 18688832 Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor 2008-01-30 2008-08-26 Fonvielle, M.,Coincon, M.,Daher, R.,Desbenoit, N.,Kosieradzka, K.,Barilone, N.,Gicquel, B.,Sygusch, J.,Jackson, M.,Therisod, M. Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics. Chemistry 2008 14 8521 8529 3DWL 18640983 Crystal Structure of Fission Yeast Arp2/3 Complex Lacking the Arp2 Subunit 2008-07-22 2008-08-26 Nolen, B.J.,Pollard, T.D. Structure and biochemical properties of fission yeast arp2/3 complex lacking the arp2 subunit. J.Biol.Chem. 2008 283 26490 26498 3BVH 18642883 Crystal Structure of Recombinant gammaD364A Fibrinogen Fragment D with the Peptide Ligand Gly-Pro-Arg-Pro-Amide 2008-01-07 2008-09-02 Bowley, S.R.,Merenbloom, B.K.,Okumura, N.,Betts, L.,Heroux, A.,Gorkun, O.V.,Lord, S.T. Polymerization-defective fibrinogen variant gammaD364A binds knob ""A"" peptide mimic. Biochemistry 2008 47 8607 8613 3DUP Crystal structure of mutt/nudix family hydrolase from rhodospirillum rubrum atcc 11170 2008-07-17 2008-09-02 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Freeman, J.,Chang, S.,Groshong, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Mutt/Nudix Family Hydrolase from Rhodospirillum Rubrum To be Published 0 0 0 0 3E7P CRYSTAL STRUCTURE OF of putative methyltransferase from Bacteroides vulgatus ATCC 8482 2008-08-18 2008-09-02 Malashkevich, v.n.,Toro, R.,meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF of putative methyltransferase from Bacteroides vulgatus ATCC 8482 To be Published 0 0 0 0 2JKK 19030106 Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor 2008-08-28 2008-09-09 Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One 2008 3 0 0 2JKM 19030106 Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor 2008-08-28 2008-09-09 Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One 2008 3 0 0 2JKO 19030106 Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor 2008-08-28 2008-09-09 Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One 2008 3 0 0 2JKQ 19030106 Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor 2008-08-29 2008-09-09 Lietha, D.,Eck, M.J. Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One 2008 3 0 0 3D59 18784071 Crystal structure of human plasma platelet activating factor acetylhydrolase 2008-05-16 2008-09-09 Samanta, U.,Bahnson, B.J. Crystal Structure of Human Plasma Platelet-activating Factor Acetylhydrolase: STRUCTURAL IMPLICATION TO LIPOPROTEIN BINDING AND CATALYSIS. J.Biol.Chem. 2008 283 31617 31624 3D5E 18784071 Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by paraoxon 2008-05-16 2008-09-09 Samanta, U.,Bahnson, B.J. 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Nature 2008 455 1263 1267 3EEY CRYSTAL STRUCTURE OF PUTATIVE RRNA-METHYLASE FROM Clostridium thermocellum 2008-09-06 2008-09-16 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Rutter, M.,Hu, S.,Bain, K.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Rrna-Methylase from Clostridium Thermocellum To be Published 0 0 0 0 3E0D 18691598 Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit 2008-07-31 2008-09-23 Wing, R.A.,Bailey, S.,Steitz, T.A. Insights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III alpha-Subunit. J.Mol.Biol. 2008 382 859 869 3EAU 18806782 Voltage-dependent K+ channel beta subunit in complex with cortisone 2008-08-26 2008-09-23 Pan, Y.,Weng, J.,Kabaleeswaran, V.,Li, H.,Cao, Y.,Bhosle, R.C.,Zhou, M. Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat.Chem.Biol. 2008 4 708 714 3EBV Crystal structure of putative Chitinase A from Streptomyces coelicolor. 2008-08-28 2008-09-30 Vigdorovich, V.,Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of putative Chitinase A from Streptomyces coelicolor To be Published 0 0 0 0 3EGO Crystal structure of Probable 2-dehydropantoate 2-reductase panE from Bacillus Subtilis 2008-09-11 2008-09-30 Ramagopal, U.A.,Toro, R.,Gilmore, M.,Hu, S.,Maletic, M.,Gheyi, T.,Burley, S.K.,Almo, S.C. Crystal structure of Probable 2-dehydropantoate 2-reductase panE from Bacillus Subtilis To be published 0 0 0 0 3DIN 18923516 Crystal structure of the protein-translocation complex formed by the SecY channel and the SecA ATPase 2008-06-20 2008-10-07 Zimmer, J.,Nam, Y.,Rapoport, T.A. Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature 2008 455 936 943 3DSH 18836453 Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain 2008-07-12 2008-10-07 Chen, W.,Lam, S.S.,Srinath, H.,Jiang, Z.,Correia, J.J.,Schiffer, C.A.,Fitzgerald, K.A.,Lin, K.,Royer, W.E. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat.Struct.Mol.Biol. 2008 15 1213 1220 3DW8 18922469 Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit 2008-07-21 2008-10-07 Xu, Y.,Chen, Y.,Zhang, P.,Jeffrey, P.D.,Shi, Y. Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol.Cell 2008 31 873 885 3EMH 18840606 Structural basis of WDR5-MLL interaction 2008-09-24 2008-10-07 Song, J.J.,Kingston, R.E. WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket. 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Biochemistry 2008 47 12729 12739 3EVN CRYSTAL STRUCTURE OF putative oxidoreductase from Streptococcus agalactiae 2603V/r 2008-10-13 2008-10-21 Malashkevich, V.N.,Toro, R.,Meyer, A.J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative Gfo/Idh/MocA family oxidoreductase from Streptococcus agalactiae 2603V/r To be Published 0 0 0 0 3BE5 19004000 Crystal structure of FitE (crystal form 1), a group III periplasmic siderophore binding protein 2007-11-16 2008-10-28 Shi, R.,Proteau, A.,Wagner, J.,Cui, Q.,Purisima, E.O.,Matte, A.,Cygler, M. Trapping open and closed forms of FitE-A group III periplasmic binding protein. Proteins 2008 75 598 609 3BE6 19004000 Crystal structure of FitE (crystal form 2), a group III periplasmic siderophore binding protein 2007-11-16 2008-10-28 Shi, R.,Proteau, A.,Wagner, J.,Cui, Q.,Purisima, E.O.,Matte, A.,Cygler, M. Trapping open and closed forms of FitE-A group III periplasmic binding protein. Proteins 2008 75 598 609 3EFY 18845161 Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli 2008-09-10 2008-10-28 Hsu, Y.,Jubelin, G.,Taieb, F.,Nougayrede, J.P.,Oswald, E.,Stebbins, C.E. Structure of the cyclomodulin Cif from pathogenic Escherichia coli. J.Mol.Biol. 2008 384 465 477 3B83 19081056 Computer-Based Redesign of a beta Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo beta Sheet Design. 2007-10-31 2008-11-04 Hu, X.,Wang, H.,Ke, H.,Kuhlman, B. Computer-Based Redesign of a beta Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo beta Sheet Design. Structure 2008 16 1799 1805 3EPR Crystal structure of putative HAD superfamily hydrolase from Streptococcus agalactiae. 2008-09-29 2008-11-04 Ramagopal, U.A.,Toro, R.,Dickey, M.,Tang, B.K.,Groshong, C.,Rodgers, L.,Burley, S.K.,Almo, S.C. Crystal structure of putative HAD superfamily hydrolase from Streptococcus agalactiae. To be Published 0 0 0 0 3DF0 19020622 Calcium-dependent complex between m-calpain and calpastatin 2008-06-11 2008-11-11 Moldoveanu, T.,Gehring, K.,Green, D.R. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature 2008 456 404 408 3EVZ Crystal structure of Methyltransferase from Pyrococcus furiosus 2008-10-13 2008-11-11 Zhang, Z.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of methyltransferase from Pyrococcus furiosus To be Published 0 0 0 0 3F0P 19004822 Crystal structure of the mercury-bound form of MerB, the Organomercurial Lyase involved in a bacterial mercury resistance system 2008-10-25 2008-11-11 Lafrance-Vanasse, J.,Lefebvre, M.,Di Lello, P.,Sygusch, J.,Omichinski, J.G. Crystal Structures of the Organomercurial Lyase MerB in Its Free and Mercury-bound Forms: INSIGHTS INTO THE MECHANISM OF METHYLMERCURY DEGRADATION J.Biol.Chem. 2009 284 938 944 3F2G 19004822 Crystal structure of MerB mutant C160S, the Organomercurial Lyase involved in a bacterial mercury resistance system 2008-10-29 2008-11-11 Lafrance-Vanasse, J.,Lefebvre, M.,Di Lello, P.,Sygusch, J.,Omichinski, J.G. Crystal Structures of the Organomercurial Lyase MerB in Its Free and Mercury-bound Forms: INSIGHTS INTO THE MECHANISM OF METHYLMERCURY DEGRADATION J.Biol.Chem. 2009 284 938 944 3F1C CRYSTAL STRUCTURE OF 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Listeria monocytogenes 2008-10-27 2008-11-18 Patskovsky, Y.,Ho, J.,Toro, R.,Gilmore, M.,Miller, S.,Groshong, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Listeria monocytogenes To be Published 0 0 0 0 3CQH 18849419 Crystal Structure of L-xylulose-5-phosphate 3-epimerase UlaE from the Anaerobic L-ascorbate Utilization Pathway of Escherichia coli 2008-04-03 2008-11-25 Shi, R.,Pineda, M.,Ajamian, E.,Cui, Q.,Matte, A.,Cygler, M. Structure of L-xylulose-5-Phosphate 3-epimerase (UlaE) from the anaerobic L-ascorbate utilization pathway of Escherichia coli: identification of a novel phosphate binding motif within a TIM barrel fold. J.Bacteriol. 2008 190 8137 8144 3E0B 19007108 Bacillus anthracis Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B) 2008-07-31 2008-11-25 Beierlein, J.M.,Frey, K.M.,Bolstad, D.B.,Pelphrey, P.M.,Joska, T.M.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase J.Med.Chem. 2008 51 7532 7540 3ECM 18983167 Crystal structure of the unliganded PDE8A catalytic domain 2008-09-01 2008-11-25 Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry 2008 47 12760 12768 3ECN 18983167 Crystal structure of PDE8A catalytic domain in complex with IBMX 2008-09-01 2008-11-25 Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry 2008 47 12760 12768 3ERY 18973345 Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors 2008-10-03 2008-11-25 Jones, L.L.,Colf, L.A.,Bankovich, A.J.,Stone, J.D.,Gao, Y.G.,Chan, C.M.,Huang, R.H.,Garcia, K.C.,Kranz, D.M. Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors Biochemistry 2008 47 12398 12408 3F5S CRYSTAL STRUCTURE OF putatitve short chain dehydrogenase from Shigella flexneri 2a str. 301 2008-11-04 2008-11-25 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putatitve short chain dehydrogenase from Shigella flexneri 2a str. 301 To be Published 0 0 0 0 2ZD9 18216238 Structure of a Bacterial Cyclic-Nucleotide Regulated Ion Channel 2007-11-21 2008-12-02 Clayton, G.M.,Altieri, S.,Heginbotham, L.,Unger, V.M.,Morais-Cabral, J.H. Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel. Proc.Natl.Acad.Sci.USA 2008 105 1511 1515 3D9Y 19028693 Crystal Structure of Profilin from Schizosaccharomyces pombe 2008-05-28 2008-12-16 Ezezika, O.C.,Younger, N.S.,Lu, J.,Kaiser, D.A.,Corbin, Z.A.,Nolen, B.J.,Kovar, D.R.,Pollard, T.D. Incompatibility with Formin Cdc12p Prevents Human Profilin from Substituting for Fission Yeast Profilin: INSIGHTS FROM CRYSTAL STRUCTURES OF FISSION YEAST PROFILIN. J.Biol.Chem. 2009 284 2088 2097 3DWO 19182779 Crystal structure of a Pseudomonas aeruginosa FadL homologue 2008-07-22 2008-12-16 Hearn, E.M.,Patel, D.R.,Lepore, B.W.,Indic, M.,van den Berg, B. Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature 2009 458 367 370 3BGT 19458715 Structural Studies of Acetoacetate Decarboxylase 2007-11-27 2008-12-23 Ho, M.C.,Menetret, J.F.,Tsuruta, H.,Allen, K.N. The origin of the electrostatic perturbation in acetoacetate decarboxylase. Nature 2009 459 393 397 3EWB Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes 2008-10-14 2008-12-23 Ramagopal, U.A.,Toro, R.,Gilmore, M.,Hu, S.,Maletic, M.,Rodgers, L.,Burley, S.K.,Almo, S.C. Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes. To be Published 0 0 0 0 3F48 19074341 Crystal structure of LeuT bound to L-alanine and sodium 2008-10-31 2008-12-23 Singh, S.K.,Piscitelli, C.L.,Yamashita, A.,Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 2008 322 1655 1661 3FHL Crystal structure of a putative oxidoreductase from bacteroides fragilis nctc 9343 2008-12-09 2008-12-23 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Gilmore, M.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of a Putative Oxidoreductase from Bacteroides Fragilis Nctc 9343 To be Published 0 0 0 0 3E2F 29712768 Crystal structure of mouse kynurenine aminotransferase III, PLP-bound form 2008-08-05 2008-12-30 Han, Q.,Robinson, H.,Cai, T.,Tagle, D.A.,Li, J. Correction for Han et al., ""Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III"". Mol. Cell. Biol. 2018 38 0 0 3E2Y 29712768 Crystal structure of mouse kynurenine aminotransferase III in complex with glutamine 2008-08-06 2008-12-30 Han, Q.,Robinson, H.,Cai, T.,Tagle, D.A.,Li, J. Correction for Han et al., ""Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III"". Mol. Cell. Biol. 2018 38 0 0 3E2Z 29712768 Crystal structure of mouse kynurenine aminotransferase III in complex with kynurenine 2008-08-06 2008-12-30 Han, Q.,Robinson, H.,Cai, T.,Tagle, D.A.,Li, J. Correction for Han et al., ""Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III"". Mol. Cell. Biol. 2018 38 0 0 3EZT 19053282 Crystal Structure Analysis of Human HDAC8 D101E Variant 2008-10-23 2008-12-30 Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry 2008 47 13554 13563 3FC0 19390148 1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells 2008-11-20 2008-12-30 Chattopadhyay, K.,Ramagopal, U.A.,Nathenson, S.G.,Almo, S.C. 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells. Acta Crystallogr.,Sect.D 2009 65 434 439 2ZJG Crystal structural of mouse kynurenine aminotransferase III 2008-03-07 2009-01-06 Han, Q.,Cai, T.,Tagle, D.A.,Robinson, H.,Li, J. Structural and functional characterization of mouse kynurenine aminotransferase III To be Published 0 0 0 0 3EZY Crystal structure of probable dehydrogenase TM_0414 from Thermotoga maritima 2008-10-24 2009-01-13 Ramagopal, U.A.,Toro, R.,Freeman, J.,Chang, S.,Maletic, M.,Gheyi, T.,Burley, S.K.,Almo, S.C. Crystal structure of probable dehydrogenase TM_0414 from Thermotoga maritima To be published 0 0 0 0 3F5Q CRYSTAL STRUCTURE OF putative short chain dehydrogenase from Escherichia coli CFT073 2008-11-04 2009-01-13 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of an uncharacterized protein to be published 0 0 0 0 3FM3 19660503 Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 2008-12-19 2009-01-13 Alvarado, J.J.,Nemkal, A.,Sauder, J.M.,Russell, M.,Akiyoshi, D.E.,Shi, W.,Almo, S.C.,Weiss, L.M. Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Mol.Biochem.Parasitol. 2009 168 158 167 3FMQ 19660503 Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor fumagillin bound 2008-12-22 2009-01-13 Alvarado, J.J.,Nemkal, A.,Sauder, J.M.,Russell, M.,Akiyoshi, D.E.,Shi, W.,Almo, S.C.,Weiss, L.M. Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Mol.Biochem.Parasitol. 2009 168 158 167 3FMR 19660503 Crystal structure of an Encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor TNP470 bound 2008-12-22 2009-01-13 Alvarado, J.J.,Nemkal, A.,Sauder, J.M.,Russell, M.,Akiyoshi, D.E.,Shi, W.,Almo, S.C.,Weiss, L.M. Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Mol.Biochem.Parasitol. 2009 168 158 167 3FN9 Crystal structure of putative beta-galactosidase from bacteroides fragilis 2008-12-23 2009-01-13 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of putative beta-galactosidase from bacteroides fragilis To be published 0 0 0 0 3EOT 19074157 Crystal structure of LAC031, an engineered anti-VLA1 Fab 2008-09-29 2009-01-20 Clark, L.A.,Boriack-Sjodin, P.A.,Day, E.,Eldredge, J.,Fitch, C.,Jarpe, M.,Miller, S.,Li, Y.,Simon, K.,van Vlijmen, H.W. An antibody loop replacement design feasibility study and a loop-swapped dimer structure. Protein Eng.Des.Sel. 2009 22 93 101 3EUH 19135891 Crystal Structure of the MukE-MukF Complex 2008-10-10 2009-01-20 Woo, J.S.,Lim, J.H.,Shin, H.C.,Suh, M.K.,Ku, B.,Lee, K.H.,Joo, K.,Robinson, H.,Lee, J.,Park, S.Y.,Ha, N.C.,Oh, B.H. Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions. Cell(Cambridge,Mass.) 2009 136 85 96 3F9B 19140798 W354F Yersinia enterocolitica PTPase complexed with divanadate 2008-11-13 2009-01-20 Brandao, T.A.,Robinson, H.,Johnson, S.J.,Hengge, A.C. Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc. 2009 131 778 786 3FHN 19151722 Structure of Tip20p 2008-12-09 2009-01-20 Tripathi, A.,Ren, Y.,Jeffrey, P.D.,Hughson, F.M. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat.Struct.Mol.Biol. 2009 16 114 123 3F2Q 19169240 Crystal structure of the FMN riboswitch bound to FMN 2008-10-30 2009-01-27 Serganov, A.,Huang, L.,Patel, D.J. Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature 2009 458 233 237 3F2W 19169240 Crystal structure of the FMn riboswitch bound to FMN, Ba2+ soak. 2008-10-30 2009-01-27 Serganov, A.,Huang, L.,Patel, D.J. Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature 2009 458 233 237 3F2Y 19169240 Crystal structure of the FMN riboswitch bound to FMN, Mn2+ soak. 2008-10-30 2009-01-27 Serganov, A.,Huang, L.,Patel, D.J. Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature 2009 458 233 237 3F30 19169240 Crystal structure of the FMN riboswitch bound to FMN, cobalt hexammine soak. 2008-10-30 2009-01-27 Serganov, A.,Huang, L.,Patel, D.J. Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature 2009 458 233 237 3F4E 19169240 Crystal structure of the FMN riboswitch bound to FMN, split RNA. 2008-10-31 2009-01-27 Serganov, A.,Huang, L.,Patel, D.J. Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature 2009 458 233 237 3F4G 19169240 Crystal structure of the FMN riboswitch bound to riboflavin. 2008-10-31 2009-01-27 Serganov, A.,Huang, L.,Patel, D.J. Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature 2009 458 233 237 3F4H 19169240 Crystal structure of the FMN riboswitch bound to roseoflavin 2008-10-31 2009-01-27 Serganov, A.,Huang, L.,Patel, D.J. Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature 2009 458 233 237 3FKD The crystal structure of L-threonine-O-3-phosphate decarboxylase from Porphyromonas gingivalis 2008-12-16 2009-02-03 Zhang, Z.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. The crystal structure of L-threonine-O-3-phosphate decarboxylase from Porphyromonas gingivalis To be Published 0 0 0 0 3D4F 18955486 SHV-1 beta-lactamase complex with LN1-255 2008-05-14 2009-02-10 Pattanaik, P.,Bethel, C.R.,Hujer, A.M.,Hujer, K.M.,Distler, A.M.,Taracila, M.,Anderson, V.E.,Fritsche, T.R.,Jones, R.N.,Pagadala, S.R.,van den Akker, F.,Buynak, J.D.,Bonomo, R.A. Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE J.Biol.Chem. 2009 284 945 953 3G1T CRYSTAL STRUCTURE OF short chain dehydrogenase from Salmonella enterica subsp. enterica serovar Typhi str. CT18 2009-01-30 2009-02-10 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF short chain dehydrogenase from Salmonella enterica subsp. enterica serovar Typhi str. CT18 To be Published 0 0 0 0 3EJY 19139174 Structure of E203H mutant of E.coli Cl-/H+ antiporter, CLC-ec1 2008-09-18 2009-02-17 Lim, H.H.,Miller, C. Intracellular proton-transfer mutants in a CLC Cl-/H+ exchanger. J.Gen.Physiol. 2009 133 131 138 3EJZ 19139174 Structure of E203V mutant E.coli Cl-/H+ exchanger, CLC-ec1 2008-09-18 2009-02-17 Lim, H.H.,Miller, C. Intracellular proton-transfer mutants in a CLC Cl-/H+ exchanger. J.Gen.Physiol. 2009 133 131 138 3G1W Crystal structure of sugar ABC transporter (sugar-binding protein) from Bacillus halodurans 2009-01-30 2009-02-17 Zhang, Z.,Eswaramoorthy, S.,Swaminathan, S.,Burley, S.K. The crystal structure of sugar ABC transporter (sugar-binding protein) from Bacillus halodurans. To be Published 0 0 0 0 3G79 Crystal structure of NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase from Methanosarcina mazei Go1 2009-02-09 2009-02-17 Malashkevich, V.N.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of NDP-N-acetyl-D-galactosaminuronic acid dehydrogenase from Methanosarcina mazei Go1 To be Published 0 0 0 0 3BP6 Crystal structure of the mouse PD-1 Mutant and PD-L2 complex 2007-12-18 2009-02-24 Yan, Q.,Lazar-Molnar, E.,Cao, E.,Ramagopal, U.A.,Toro, R.,Nathenson, S.G.,Almo, S.C. Crystal structure of the mouse PD-1 A99L and PD-L2 complex To be published 0 0 0 0 3G7U Crystal structure of putative DNA modification methyltransferase encoded within prophage Cp-933R (E.coli) 2009-02-10 2009-02-24 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Gilmore, M.,Iizuka, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of DNA Modification Methyltransferase Encoded within Prophage Cp-933R (E.coli) To be Published 0 0 0 0 3G1P Crystals structure of PhnP from E.coli K-12 2009-01-30 2009-03-03 Podzelinska, K.,He, S.,Wathier, M.,Yakunin, A.,Proudftoot, M.,Hove-Jensen, B.,Zechel, D.,Jia, Z. Crystals structure of PhnP from E.coli K-12 To be Published 0 0 0 0 3G8D 19213731 Crystal structure of the biotin carboxylase subunit, E296A mutant, of acetyl-COA carboxylase from Escherichia coli 2009-02-12 2009-03-03 Chou, C.Y.,Yu, L.P.,Tong, L. Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. J.Biol.Chem. 2009 284 11690 11697 3CFR Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 2 2008-03-04 2009-03-10 Klimenko, D.,Wang, M.,Steitz, T.A.,Konigsberg, W.H.,Wang, J. Insights into base selectivity from the structures of an RB69 DNA Polymerase triple mutant To be Published 0 0 0 0 3DP9 19270684 Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with butylthio-DADMe-Immucillin A 2008-07-07 2009-03-10 Gutierrez, J.A.,Crowder, T.,Rinaldo-Matthis, A.,Ho, M.C.,Almo, S.C.,Schramm, V.L. Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Nat.Chem.Biol. 2009 5 251 257 3GBU Crystal structure of an uncharacterized sugar kinase PH1459 from Pyrococcus horikoshii in complex with ATP 2009-02-20 2009-03-10 Eswaramoorthy, S.,Kumar, G.,Zhang, Z.,Burley, S.K.,Swaminathan, S. Crystal structure of an uncharacterized sugar kinase PH1459 from Pyrococcus horikoshii in complex with ATP To be Published 0 0 0 0 3CIS The Crystal Structure of Rv2623 from Mycobacterium tuberculosis 2008-03-11 2009-03-17 Drumm, J.,Mi, K.,Bilder, P.,Almo, S.C.,Chan, J. The Crystal Structure of Rv2623 : a Novel, Tandem-Repeat Universal Stress Protein of Mycobacterium tuberculosis To be Published 0 0 0 0 3GHY Crystal structure of a putative ketopantoate reductase from Ralstonia solanacearum MolK2 2009-03-04 2009-03-17 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Morano, C.,Freeman, J.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of a putative ketopantoate reductase from Ralstonia solanacearum MolK2 To be Published 0 0 0 0 3F0B 19249312 Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine 2008-10-24 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3F0U 19249312 Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine 2008-10-26 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3FQ0 19249312 Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B) 2009-01-06 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3FQC 19249312 Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A) 2009-01-07 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3FQF 19249312 Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A) 2009-01-07 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3FQO 19249312 Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(2,5-dimethoxyphenyl)prop-1-ynyl]-6-ethylpyrimidine (UCP120B) 2009-01-07 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3FQV 19249312 Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)but-1-ynyl]-6-methylpyrimidine 2009-01-07 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3FQZ 19249312 Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl)but-1-ynyl]-6-methylpyrimidine 2009-01-07 2009-03-24 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Wright, D.L.,Anderson, A.C. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J.Mol.Biol. 2009 387 1298 1308 3G17 Structure of putative 2-dehydropantoate 2-reductase from staphylococcus aureus 2009-01-29 2009-03-24 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of putative 2-dehydropantoate 2-reductase from staphylococcus aureus To be published 0 0 0 0 3GFO Structure of cbiO1 from clostridium perfringens: Part of the ABC transporter complex cbiONQ. 2009-02-27 2009-03-24 Ramagopal, U.A.,Morano, C.,Toro, R.,Dickey, M.,Do, J.,Burley, S.K.,Almo, S.C. Structure of cbiO1 from clostridium perfringens: Part of the ABC transporter complex cbiONQ To be published 0 0 0 0 3GG9 CRYSTAL STRUCTURE OF putative D-3-phosphoglycerate dehydrogenase oxidoreductase from Ralstonia solanacearum 2009-02-27 2009-03-24 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Morano, C.,Freeman, J.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Putative D-3-Phosphoglycerate Dehydrogenase from Ralstonia Solanacearum To be Published 0 0 0 0 3GMF Crystal structure of protein-disulfide isomerase from Novosphingobium aromaticivorans 2009-03-13 2009-03-24 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Morano, C.,Freeman, J.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of protein-disulfide isomerase from Novosphingobium aromaticivorans To be Published 0 0 0 0 3GPK Crystal Structure of PpiC-type peptidyl-prolyl cis-trans isomerase domain at 1.55A resolution. 2009-03-23 2009-03-31 Satyanarayana, L.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal Structure of PpiC-type peptidyl-prolyl cis-trans isomerase domain at 1.55A resolution. To be Published 0 0 0 0 3D9E 19265437 Nitroalkane oxidase: active site mutant D402N crystallized with 1-nitrooctane 2008-05-27 2009-04-07 Heroux, A.,Bozinovski, D.M.,Valley, M.P.,Fitzpatrick, P.F.,Orville, A.M. Crystal structures of intermediates in the nitroalkane oxidase reaction. Biochemistry 2009 48 3407 3416 3D9G 19265437 Nitroalkane oxidase: wild type crystallized in a trapped state forming a cyanoadduct with FAD 2008-05-27 2009-04-07 Heroux, A.,Bozinovski, D.M.,Valley, M.P.,Fitzpatrick, P.F.,Orville, A.M. Crystal structures of intermediates in the nitroalkane oxidase reaction. Biochemistry 2009 48 3407 3416 3E3C 19228114 Structure of GrlR-lipid complex 2008-08-07 2009-04-07 Jobichen, C.,Fernandis, A.Z.,Velazquez-Campoy, A.,Leung, K.Y.,Mok, Y.K.,Wenk, M.R.,Sivaraman, J. Identification and characterization of the lipid binding property of GrlR, a locus of enterocyte effacement regulator. Biochem.J. 2009 0 0 0 3G06 19273841 The Salmonella Virulence Effector SspH2 Functions As A Novel E3 Ligase 2009-01-27 2009-04-07 Quezada, C.M.,Hicks, S.W.,Galan, J.E.,Stebbins, C.E. A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases. Proc.Natl.Acad.Sci.USA 2009 106 4864 4869 3G8R Crystal structure of putative spore coat polysaccharide biosynthesis protein E from Chromobacterium violaceum ATCC 12472 2009-02-12 2009-04-07 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative spore coat polysaccharide biosynthesis protein E from Chromobacterium violaceum ATCC 12472 To be Published 0 0 0 0 3GRZ CRYSTAL STRUCTURE OF ribosomal protein L11 methylase FROM Lactobacillus delbrueckii subsp. bulgaricus 2009-03-26 2009-04-07 Patskovsky, Y.,Ramagopal, U.A.,Toro, R.,Morano, C.,Freeman, J.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN 11 METHYLASE FROM Lactobacillus delbrueckii subsp. bulgaricus To be Published 0 0 0 0 3GPV Crystal structure of a transcriptional regulator, MerR family from Bacillus thuringiensis 2009-03-23 2009-04-14 Palani, K.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a transcriptional regulator, MerR family from Bacillus thuringiensis To be Published 0 0 0 0 3GRC Crystal structure of a sensor protein from Polaromonas sp. JS666 2009-03-25 2009-04-14 Palani, K.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a sensor protein from Polaromonas sp. JS666 To be Published 0 0 0 0 3GT7 CRYSTAL STRUCTURE OF SIGNAL RECEIVER DOMAIN OF SIGNAL TRANSDUCTION HISTIDINE KINASE FROM Syntrophus aciditrophicus 2009-03-27 2009-04-14 Patskovsky, Y.,Toro, R.,Morano, C.,Freeman, J.,Hu, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Signal Receiver Domain of Signal Transduction Kinase from Syntrophus Aciditrophicus To be Published 0 0 0 0 3GV0 Crystal structure of LacI family transcription regulator from Agrobacterium tumefaciens 2009-03-30 2009-04-14 Bagaria, A.,Burley, S.K.,Swaminathan, S. Crystal structure of LacI family transcription regulator from Agrobacterium tumefaciens To be Published 0 0 0 0 3GV1 Crystal structure of disulfide interchange protein from Neisseria gonorrhoeae 2009-03-30 2009-04-14 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of disulfide interchange protein from Neisseria gonorrhoeae To be Published 0 0 0 0 3GW7 Crystal structure of a metal-dependent phosphohydrolase with conserved HD domain (yedJ) from Escherichia coli in complex with nickel ions. Northeast Structural Genomics Consortium Target ER63 2009-03-31 2009-04-14 Forouhar, F.,Abashidze, M.,Seetharaman, J.,Janjua, J.,Xiao, R.,Cunningham, K.,Ma, L.,Zhao, L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of a metal-dependent phosphohydrolase with conserved HD domain (yedJ) from Escherichia coli in complex with nickel ions. Northeast Structural Genomics Consortium Target ER63 To be Published 0 0 0 0 3GY0 Crystal structure of putatitve short chain dehydrogenase FROM SHIGELLA FLEXNERI 2A STR. 301 complexed with NADP 2009-04-03 2009-04-14 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putatitve short chain dehydrogenase FROM SHIGELLA FLEXNERI 2A STR. 301 complexed with NADP To be Published 0 0 0 0 3GY1 CRYSTAL STRUCTURE OF putative mandelate racemase/muconate lactonizing protein from Clostridium beijerinckii NCIMB 8052 2009-04-03 2009-04-14 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative mandelate racemase/muconate lactonizing protein from Clostridium beijerinckii NCIMB 8052 To be Published 0 0 0 0 3GYB Crystal structure of a LacI-family transcriptional regulatory protein from Corynebacterium glutamicum 2009-04-03 2009-04-14 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of a LacI-family transcriptional regulatory protein from Corynebacterium glutamicum To be Published 0 0 0 0 3GZ4 Crystal structure of putative short chain dehydrogenase FROM ESCHERICHIA COLI CFT073 complexed with NADPH 2009-04-06 2009-04-14 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative short chain dehydrogenase FROM ESCHERICHIA COLI CFT073 complexed with NADPH To be Published 0 0 0 0 3G7L 19362535 Chromodomain of Chp1 in complex with Histone H3K9me3 peptide 2009-02-10 2009-04-21 Schalch, T.,Job, G.,Noffsinger, V.J.,Shanker, S.,Kuscu, C.,Joshua-Tor, L.,Partridge, J.F. High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin Mol.Cell 2009 34 36 46 3GNL Structure of uncharacterized protein (LMOf2365_1472) from Listeria monocytogenes serotype 4b 2009-03-17 2009-04-21 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of uncharacterized protein (LMOf2365_1472) from Listeria monocytogenes serotype 4b To be Published 0 0 0 0 3GP4 Crystal structure of putative MerR family transcriptional regulator from listeria monocytogenes 2009-03-20 2009-04-21 Ramagopal, U.A.,Toro, R.,Morano, C.,Burley, S.K.,Almo, S.C. Structure of putative MerR family transcriptional regulator from Listeria monocytogenes To be published 0 0 0 0 3GPI Structure of putative NAD-dependent epimerase/dehydratase from methylobacillus flagellatus 2009-03-23 2009-04-21 Ramagopal, U.A.,Morano, C.,Burley, S.K.,Almo, S.C. Structure of putative NAD-dependent epimerase/dehydratase from methylobacillus flagellatus To be published 0 0 0 0 3H12 Crystal structure of putative mandelate racemase from Bordetella Bronchiseptica RB50 2009-04-10 2009-04-21 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative mandelate racemase from Bordetella Bronchiseptica RB50 To be Published 0 0 0 0 3FMT 19304745 Crystal structure of SeqA bound to DNA 2008-12-22 2009-04-28 Chung, Y.S.,Brendler, T.,Austin, S.,Guarne, A. Structural insights into the cooperative binding of SeqA to a tandem GATC repeat Nucleic Acids Res. 2009 37 3143 3152 3G3N 19350606 PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one 2009-02-02 2009-04-28 Castano, T.,Wang, H.,Campillo, N.E.,Ballester, S.,Gonzalez-Garcia, C.,Hernandez, J.,Perez, C.,Cuenca, J.,Perez-Castillo, A.,Martinez, A.,Huertas, O.,Gelpi, J.L.,Luque, F.J.,Ke, H.,Gil, C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors Chemmedchem 2009 4 866 876 3G4S 19362093 Co-crystal structure of Tiamulin bound to the large ribosomal subunit 2009-02-04 2009-04-28 Gurel, G.,Blaha, G.,Moore, P.B.,Steitz, T.A. U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J.Mol.Biol. 2009 389 146 156 3G6E 19362093 Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit 2009-02-06 2009-04-28 Gurel, G.,Blaha, G.,Moore, P.B.,Steitz, T.A. U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J.Mol.Biol. 2009 389 146 156 3G71 19362093 Co-crystal structure of Bruceantin bound to the large ribosomal subunit 2009-02-09 2009-04-28 Gurel, G.,Blaha, G.,Moore, P.B.,Steitz, T.A. U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J.Mol.Biol. 2009 389 146 156 3GMS Crystal structure of putative NADPH:quinone reductase from bacillus thuringiensis 2009-03-14 2009-04-28 Ramagopal, U.A.,Morano, C.,Burley, S.K.,Almo, S.C. Structure of putative NADPH:quinone reductase from Bacillus thuringiensis To be published 0 0 0 0 3GVX Crystal structure of Glycerate dehydrogenase related protein from Thermoplasma acidophilum 2009-03-31 2009-04-28 Syed Ibrahim, B.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal Structure of Glycerate dehydrogenase related protein from Thermoplasma acidophilum To be Published 0 0 0 0 3H11 19416807 Zymogen caspase-8:c-FLIPL protease domain complex 2009-04-10 2009-04-28 Yu, J.W.,Jeffrey, P.D.,Shi, Y. Mechanism of procaspase-8 activation by c-FLIPL. Proc.Natl.Acad.Sci.USA 2009 106 8169 8174 3H13 19416807 c-FLIPL protease-like domain 2009-04-10 2009-04-28 Yu, J.W.,Jeffrey, P.D.,Shi, Y. Mechanism of procaspase-8 activation by c-FLIPL. Proc.Natl.Acad.Sci.USA 2009 106 8169 8174 3H49 Crystal structure of a putative Ribokinase (Apo Form) from E.coli at 1.8A resolution 2009-04-18 2009-04-28 Satyanarayana, L.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative Ribokinase (Apo Form) from E.coli at 1.8A resolution. To be Published 0 0 0 0 3DYH 19309137 T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-721 2008-07-27 2009-05-05 Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.K.,Lin, F.Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc. 2009 131 5153 5162 3EFQ 19309137 T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-714 2008-09-09 2009-05-05 Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.K.,Lin, F.Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc. 2009 131 5153 5162 3EGT 19309137 T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-722 2008-09-11 2009-05-05 Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.K.,Lin, F.Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc. 2009 131 5153 5162 3GM1 19358827 Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 in Complex with Paxillin LD4 Motif-Derived Peptides 2009-03-12 2009-05-05 Lulo, J.,Yuzawa, S.,Schlessinger, J. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2 Biochem.Biophys.Res.Commun. 2009 383 347 352 3GM2 19358827 Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 2009-03-12 2009-05-05 Lulo, J.,Yuzawa, S.,Schlessinger, J. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2 Biochem.Biophys.Res.Commun. 2009 383 347 352 3GM3 19358827 Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 2009-03-12 2009-05-05 Lulo, J.,Yuzawa, S.,Schlessinger, J. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2 Biochem.Biophys.Res.Commun. 2009 383 347 352 3H5O The crystal structure of transcription regulator GntR from Chromobacterium violaceum 2009-04-22 2009-05-05 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of transcription regulator GntR from Chromobacterium violaceum To be Published 0 0 0 0 3H7A CRYSTAL STRUCTURE OF SHORT-CHAIN DEHYDROGENASE FROM Rhodopseudomonas palustris 2009-04-24 2009-05-05 Patskovsky, Y.,Toro, R.,Morano, C.,Miller, S.,Freeman, J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF SHORT-CHAIN DEHYDROGENASE FROM Rhodopseudomonas palustris To be Published 0 0 0 0 3D0O Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus 2008-05-02 2009-05-12 Ho, M.,Gutierrez, J.A.,Almo, S.C.,Schramm, V.L. Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus To be Published 0 0 0 0 3GWU 19430461 Leucine transporter LeuT in complex with sertraline 2009-04-01 2009-05-12 Zhou, Z.,Zhen, J.,Karpowich, N.K.,Law, C.J.,Reith, M.E.,Wang, D.N. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol. 2009 16 652 657 3GWV 19430461 Leucine transporter LeuT in complex with R-fluoxetine 2009-04-01 2009-05-12 Zhou, Z.,Zhen, J.,Karpowich, N.K.,Law, C.J.,Reith, M.E.,Wang, D.N. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol. 2009 16 652 657 3GWW 19430461 Leucine transporter LeuT in complex with S-fluoxetine 2009-04-01 2009-05-12 Zhou, Z.,Zhen, J.,Karpowich, N.K.,Law, C.J.,Reith, M.E.,Wang, D.N. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol. 2009 16 652 657 3H75 Crystal Structure of a Periplasmic Sugar-binding protein from the Pseudomonas fluorescens 2009-04-24 2009-05-12 Kumaran, D.,Mahmood, A.,Burley, S.K.,Swaminathan, S. Crystal Structure of a Periplasmic Sugar-binding protein from the Pseudomonas fluorescens To be Published 0 0 0 0 3H7L CRYSTAL STRUCTURE OF ENDOGLUCANASE-RELATED PROTEIN FROM Vibrio parahaemolyticus 2009-04-27 2009-05-12 Patskovsky, Y.,Toro, R.,Morano, C.,Rutter, M.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF ENDOGLUCANASE-RELATED PROTEIN FROM Vibrio parahaemolyticus To be Published 0 0 0 0 3FVS 19338303 Human Kynurenine Aminotransferase I in complex with Glycerol 2009-01-16 2009-05-19 Han, Q.,Robinson, H.,Cai, T.,Tagle, D.A.,Li, J. Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K J.Med.Chem. 2009 52 2786 2793 3FVU 19338303 Crystal Structure of Human Kynurenine Aminotransferase I in Complex with Indole-3-acetic Acid 2009-01-16 2009-05-19 Han, Q.,Robinson, H.,Cai, T.,Tagle, D.A.,Li, J. Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K J.Med.Chem. 2009 52 2786 2793 3FVX 19338303 Human kynurenine aminotransferase I in complex with tris 2009-01-16 2009-05-19 Han, Q.,Robinson, H.,Cai, T.,Tagle, D.A.,Li, J. Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K J.Med.Chem. 2009 52 2786 2793 3GQC 19464298 Structure of human Rev1-DNA-dNTP ternary complex 2009-03-24 2009-05-19 Swan, M.K.,Johnson, R.E.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structure of the human Rev1-DNA-dNTP ternary complex. J.Mol.Biol. 2009 390 699 709 3HCW CRYSTAL STRUCTURE OF PROBABLE maltose operon transcriptional repressor malR FROM STAPHYLOCOCCUS AREUS 2009-05-06 2009-05-19 Patskovsky, Y.,Toro, R.,Morano, C.,Freeman, J.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Maltose Operon Transcriptional Repressor from Staphylococcus Aureus To be Published 0 0 0 0 3HDG Crystal structure of the N-terminal domain of an uncharacterized protein (WS1339) from Wolinella succinogenes 2009-05-07 2009-05-19 Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of the N-terminal domain of an uncharacterized protein (WS1339) from Wolinella succinogenes To be Published 0 0 0 0 3HEB Crystal Structure of Response regulator receiver domain from Rhodospirillum rubrum 2009-05-08 2009-05-19 Syed Ibrahim, B.,Burley, S.K.,Swaminathan, S. Crystal Structure of Response regulator receiver domain from Rhodospirillum rubrum To be Published 0 0 0 0 3H74 Crystal structure of pyridoxal kinase from Lactobacillus plantarum 2009-04-24 2009-05-26 Bagaria, A.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of pyridoxal kinase from Lactobacillus plantarum To be Published 0 0 0 0 3HBN 19483088 Crystal structure PseG-UDP complex from Campylobacter jejuni 2009-05-04 2009-05-26 Rangarajan, E.S.,Proteau, A.,Cui, Q.,Logan, S.M.,Potetinova, Z.,Whitfield, D.,Purisima, E.O.,Cygler, M.,Matte, A.,Sulea, T.,Schoenhofen, I.C. Structural and functional analysis of Campylobacter jejuni PseG: a udp-sugar hydrolase from the pseudaminic acid biosynthetic pathway. J.Biol.Chem. 2009 284 20989 21000 3HDV Crystal structure of response regulator receiver protein from Pseudomonas putida 2009-05-07 2009-05-26 Bagaria, A.,Burley, S.K.,Swaminathan, S. Crystal structure of response regulator receiver protein from Pseudomonas putida To be Published 0 0 0 0 3HG7 CRYSTAL STRUCTURE OF D-isomer specific 2-hydroxyacid dehydrogenase family protein from Aeromonas salmonicida subsp. salmonicida A449 2009-05-13 2009-05-26 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF D-isomer specific 2-hydroxyacid dehydrogenase family protein from Aeromonas salmonicida subsp. salmonicida A449 To be Published 0 0 0 0 3D4P Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus complexed with NAD and pyruvate 2008-05-14 2009-06-02 Schramm, V.L.,Almo, S.C.,Gutierrez, J.A.,Ho, M. Crystal structure of Lactate Dehydrogenase from Staphylococcus Aureus complexed with NAD and pyruvate To be Published 0 0 0 0 3H6E The crystal structure of a carbohydrate kinase from Novosphingobium aromaticivorans 2009-04-23 2009-06-02 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of carbohydrate kinase from Novosphingobium aromaticivorans To be Published 0 0 0 0 3HIN CRYSTAL STRUCTURE OF putative enoyl-CoA hydratase from Rhodopseudomonas palustris CGA009 2009-05-20 2009-06-02 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative enoyl-CoA hydratase from Rhodopseudomonas palustris CGA009 To be Published 0 0 0 0 3HJG Crystal structure of putative alpha-ribazole-5'-phosphate phosphatase CobC FROM Vibrio parahaemolyticus 2009-05-21 2009-06-02 Patskovsky, Y.,Toro, R.,Morano, C.,Rutter, M.,Iizuka, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative alpha-ribazole-5' -phosphate phosphatase FROM Vibrio parahaemolyticus To be Published 0 0 0 0 3H43 19481527 N-terminal domain of the proteasome-activating nucleotidase of Methanocaldococcus jannaschii 2009-04-17 2009-06-09 Zhang, F.,Hu, M.,Tian, G.,Zhang, P.,Finley, D.,Jeffrey, P.D.,Shi, Y. Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii. Mol.Cell 2009 34 473 484 3H4M 19481527 AAA ATPase domain of the proteasome- activating nucleotidase 2009-04-20 2009-06-09 Zhang, F.,Hu, M.,Tian, G.,Zhang, P.,Finley, D.,Jeffrey, P.D.,Shi, Y. Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii. Mol.Cell 2009 34 473 484 3H4P 19481527 Proteasome 20S core particle from Methanocaldococcus jannaschii 2009-04-20 2009-06-09 Zhang, F.,Hu, M.,Tian, G.,Zhang, P.,Finley, D.,Jeffrey, P.D.,Shi, Y. Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii. Mol.Cell 2009 34 473 484 3HN2 Crystal structure of 2-dehydropantoate 2-reductase FROM Geobacter metallireducens GS-15 2009-05-29 2009-06-09 Patskovsky, Y.,Toro, R.,Morano, C.,Rutter, M.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of 2-dehydropantoate 2-reductase FROM Geobacter metallireducens To be Published 0 0 0 0 3HAH 19549836 Crystal structure of human PACSIN1 F-BAR domain (C2 lattice) 2009-05-01 2009-06-16 Wang, Q.,Navarro, M.V.,Peng, G.,Molinelli, E.,Lin Goh, S.,Judson, B.L.,Rajashankar, K.R.,Sondermann, H. Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc.Natl.Acad.Sci.USA 2009 106 12700 12705 3FD9 19235906 Crystal Structure of the transcriptional anti-activator ExsD from Pseudomonas aeruginosa 2008-11-25 2009-06-23 Bernhards, R.C.,Jing, X.,Vogelaar, N.J.,Robinson, H.,Schubot, F.D. Structural evidence suggests that antiactivator ExsD from Pseudomonas aeruginosa is a DNA binding protein Protein Sci. 2009 18 503 513 3FII 19543288 Crystal structure of Clostridium botulinum neurotoxin serotype F catalytic domain with an inhibitor (inh2) 2008-12-11 2009-06-23 Agarwal, R.,Schmidt, J.J.,Stafford, R.G.,Swaminathan, S. Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F. Nat.Struct.Mol.Biol. 2009 16 789 794 3G39 19543291 Structure of a lamprey variable lymphocyte receptor 2009-02-02 2009-06-23 Velikovsky, C.A.,Deng, L.,Tasumi, S.,Iyer, L.M.,Kerzic, M.C.,Aravind, L.,Pancer, Z.,Mariuzza, R.A. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat.Struct.Mol.Biol. 2009 16 725 730 3G3A 19543291 Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen 2009-02-02 2009-06-23 Velikovsky, C.A.,Deng, L.,Tasumi, S.,Iyer, L.M.,Kerzic, M.C.,Aravind, L.,Pancer, Z.,Mariuzza, R.A. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat.Struct.Mol.Biol. 2009 16 725 730 3G3B 19543291 Structure of a lamprey variable lymphocyte receptor mutant in complex with a protein antigen 2009-02-02 2009-06-23 Velikovsky, C.A.,Deng, L.,Tasumi, S.,Iyer, L.M.,Kerzic, M.C.,Aravind, L.,Pancer, Z.,Mariuzza, R.A. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat.Struct.Mol.Biol. 2009 16 725 730 3HP0 Crystal structure of a Putative polyketide biosynthesis enoyl-CoA hydratase (pksH) from Bacillus subtilis 2009-06-03 2009-06-23 Satyanarayana, L.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of a Putative polyketide biosynthesis enoyl-CoA hydratase (pksH) from Bacillus subtilis To be Published 0 0 0 0 3HS3 Crystal structure of periplasmic binding ribose operon repressor protein from Lactobacillus acidophilus 2009-06-10 2009-06-23 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of periplasmic binding ribose operon repressor protein from Lactobacillus acidophilus To be Published 0 0 0 0 3HV1 Crystal structure of a polar amino acid ABC uptake transporter substrate binding protein from Streptococcus thermophilus 2009-06-15 2009-06-23 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of a polar amino acid ABC uptake transporter substrate binding protein from Streptococcus thermophilus To be Published 0 0 0 0 3HV2 Crystal structure of signal receiver domain OF HD domain-containing protein FROM Pseudomonas fluorescens Pf-5 2009-06-15 2009-06-23 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Freeman, J.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of signal receiver domain oF HD domain-containing protein 3 FROM Pseudomonas fluorescens To be Published 0 0 0 0 3HU5 CRYSTAL STRUCTURE OF isochorismatase family protein from Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 2009-06-12 2009-06-30 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF isochorismatase family protein from Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough To be Published 0 0 0 0 3HUT Crystal structure of a putative branched-chain amino acid ABC transporter from Rhodospirillum rubrum 2009-06-15 2009-06-30 Satyanarayana, L.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative branched-chain amino acid ABC transporter from Rhodospirillum rubrum To be Published 0 0 0 0 3HZ4 Crystal Structure of Thioredoxin from Methanosarcina mazei 2009-06-23 2009-06-30 Syed Ibrahim, B.,Burley, S.K.,Swaminathan, S. Crystal Structure of Thioredoxin from Methanosarcina mazei To be Published 0 0 0 0 3HUU Crystal structure of transcription regulator like protein from Staphylococcus haemolyticus 2009-06-15 2009-07-07 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of transcription regulator like protein from Staphylococcus haemolyticus To be Published 0 0 0 0 3ECB 19625641 Crystal structure of mouse H-2Dd in complex with peptide P18-I10 derived from human immunodeficiency virus envelope glycoprotein 120 2008-08-29 2009-07-14 Wang, R.,Natarajan, K.,Margulies, D.H. Structural basis of the CD8alphabeta/MHC class i interaction: focused recognition orients CD8beta to a T cell proximal position J.Immunol. 2009 183 2554 2564 3H15 19608746 Crystal structure of replication initiation factor MCM10-ID bound to ssDNA 2009-04-10 2009-07-14 Warren, E.M.,Huang, H.,Fanning, E.,Chazin, W.J.,Eichman, B.F. Physical Interactions between Mcm10, DNA, and DNA Polymerase {alpha}. J.Biol.Chem. 2009 284 24662 24672 3HUL Structure of putative homoserine kinase thrB from Listeria monocytogenes 2009-06-15 2009-07-14 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of putative homoserine kinase thrB from Listeria monocytogenes To be published 0 0 0 0 3I3V Crystal Structure of probable secreted solute-binding lipoprotein from Streptomyces coelicolor 2009-07-01 2009-07-14 Damodhran, L.,Burley, S.K.,Swaminathan, S. Crystal Structure of probable secreted solute-binding lipoprotein from Streptomyces coelicolor To be Published 0 0 0 0 3I45 CRYSTAL STRUCTURE OF putative twin-arginine translocation pathway signal protein from Rhodospirillum rubrum Atcc 11170 2009-07-01 2009-07-14 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative twin-arginine translocation pathway signal protein from Rhodospirillum rubrum Atcc 11170 To be Published 0 0 0 0 3I47 CRYSTAL STRUCTURE OF putative enoyl CoA hydratase/isomerase (crotonase) from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 2009-07-01 2009-07-14 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative enoyl CoA hydratase/isomerase (crotonase) from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 To be Published 0 0 0 0 3I4S CRYSTAL STRUCTURE OF HISTIDINE TRIAD PROTEIN blr8122 FROM Bradyrhizobium japonicum 2009-07-02 2009-07-14 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Freeman, J.,Do, J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF HISTIDINE TRIAD PROTEIN FROM Bradyrhizobium japonicum To be Published 0 0 0 0 3I5T CRYSTAL STRUCTURE OF AMINOTRANSFERASE PRK07036 FROM Rhodobacter sphaeroides KD131 2009-07-06 2009-07-14 Patskovsky, Y.,Toro, R.,Freeman, J.,Do, J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF AMINOTRANSFERASE PRK07036 FROM Rhodobacter sphaeroides To be Published 0 0 0 0 3A46 19625256 Crystal structure of MvNei1/THF complex 2009-07-01 2009-07-21 Imamura, K.,Wallace, S.S.,Doublie, S. Structural Characterization of a Viral NEIL1 Ortholog Unliganded and Bound to Abasic Site-containing DNA J.Biol.Chem. 2009 284 26174 26183 3HR0 19651599 Crystal structure of Homo sapiens Conserved Oligomeric Golgi subunit 4 2009-06-08 2009-07-21 Richardson, B.C.,Smith, R.D.,Ungar, D.,Nakamura, A.,Jeffrey, P.D.,Lupashin, V.V.,Hughson, F.M. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proc.Natl.Acad.Sci.USA 2009 106 13329 13334 3HR0 19651599 Crystal structure of Homo sapiens Conserved Oligomeric Golgi subunit 4 2009-06-08 2009-07-21 Richardson, B.C.,Smith, R.D.,Ungar, D.,Nakamura, A.,Jeffrey, P.D.,Lupashin, V.V.,Hughson, F.M. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proc.Natl.Acad.Sci.USA 2009 106 13329 13334 3HZ6 Crystal structure of xylulokinase from Chromobacterium violaceum 2009-06-23 2009-07-21 Zhang, Z.,Burley, S.K.,Swaminathan, S. Crystal structure of xylulokinase from Chromobacterium violaceum To be Published 0 0 0 0 3IA1 Crystal structure of thio-disulfide isomerase from Thermus thermophilus 2009-07-13 2009-07-21 Patskovsky, Y.,Toro, R.,Freeman, J.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of thio-disulfide isomerase from Thermus thermophilus To be Published 0 0 0 0 3DXK 19648907 Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636 2008-07-24 2009-07-28 Nolen, B.J.,Tomasevic, N.,Russell, A.,Pierce, D.W.,Jia, Z.,McCormick, C.D.,Hartman, J.,Sakowicz, R.,Pollard, T.D. Characterization of two classes of small molecule inhibitors of Arp2/3 complex Nature 2009 460 1031 1034 3DXM 19648907 Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548 2008-07-24 2009-07-28 Nolen, B.J.,Tomasevic, N.,Russell, A.,Pierce, D.W.,Jia, Z.,McCormick, C.D.,Hartman, J.,Sakowicz, R.,Pollard, T.D. Characterization of two classes of small molecule inhibitors of Arp2/3 complex Nature 2009 460 1031 1034 3FF7 19604491 Structure of NK cell receptor KLRG1 bound to E-cadherin 2008-12-02 2009-07-28 Li, Y.,Hofmann, M.,Wang, Q.,Teng, L.,Chlewicki, L.K.,Pircher, H.,Mariuzza, R.A. Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity 2009 31 35 46 3FF8 19604491 Structure of NK cell receptor KLRG1 bound to E-cadherin 2008-12-02 2009-07-28 Li, Y.,Hofmann, M.,Wang, Q.,Teng, L.,Chlewicki, L.K.,Pircher, H.,Mariuzza, R.A. Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. Immunity 2009 31 35 46 3I42 Structure of response regulator receiver domain (CheY-like) from Methylobacillus flagellatus 2009-07-01 2009-07-28 Ramagopal, U.A.,Morano, C.,Burley, S.K.,Almo, S.C. Structure of response regulator receiver domain (CheY-like) from Methylobacillus flagellatus To be published 0 0 0 0 3I4F Structure of putative 3-oxoacyl-reductase from bacillus thuringiensis 2009-07-01 2009-07-28 Ramagopal, U.A.,Kim, J.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of putative 3-oxoacyl-reductase from bacillus thuringiensis To be published 0 0 0 0 3IBM CRYSTAL STRUCTURE OF cupin 2 domain-containing protein Hhal_0468 FROM Halorhodospira halophila 2009-07-16 2009-07-28 Patskovsky, Y.,Toro, R.,Freeman, J.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF cupin 2 domain-containing PROTEIN Hhal_0468 FROM Halorhodospira halophila To be Published 0 0 0 0 3IBQ Crystal structure of pyridoxal kinase from Lactobacillus plantarum in complex with ATP 2009-07-16 2009-07-28 Bagaria, A.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of pyridoxal kinase from Lactobacillus plantarum in complex with ATP To be Published 0 0 0 0 3HC0 19626705 BHA10 IgG1 wild-type Fab - antibody directed at human LTBR 2009-05-05 2009-08-04 Jordan, J.L.,Arndt, J.W.,Hanf, K.,Li, G.,Hall, J.,Demarest, S.,Huang, F.,Wu, X.,Miller, B.,Glaser, S.,Fernandez, E.J.,Wang, D.,Lugovskoy, A. Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules Proteins 2009 77 832 841 3IGH Crystal structure of an uncharacterized metal-dependent hydrolase from pyrococcus horikoshii ot3 2009-07-27 2009-08-04 Patskovsky, Y.,Toro, R.,Freeman, J.,Miller, S.,Sauder, J.M.,Raushel, F.M.,Burley, S.K.,Almo, S.C. Crystal Structure of an Uncharacterized Metal-Dependent Hydrolase from Pyrococcus Horikoshii To be Published 0 0 0 0 3H4C 19666603 Structure of the C-terminal Domain of Transcription Factor IIB from Trypanosoma brucei 2009-04-18 2009-08-11 Ibrahim, B.S.,Kanneganti, N.,Rieckhof, G.E.,Das, A.,Laurents, D.V.,Palenchar, J.B.,Bellofatto, V.,Wah, D.A. Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei. Proc.Natl.Acad.Sci.USA 2009 106 13242 13247 3DGR 19666527 Crystal structure of human NAMPT complexed with ADP analogue 2008-06-15 2009-08-18 Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA 2009 106 13748 13753 3DHD 19666527 Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate 2008-06-17 2009-08-18 Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA 2009 106 13748 13753 3DHF 19666527 Crystal structure of phosphorylated mimic form of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate 2008-06-17 2009-08-18 Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA 2009 106 13748 13753 3DKJ 19666527 Crystal structure of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate 2008-06-25 2009-08-18 Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA 2009 106 13748 13753 3DKL 19666527 Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate 2008-06-25 2009-08-18 Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA 2009 106 13748 13753 3E6F 19620307 MHC CLASS I H-2Dd Heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PA9, from the Human immunodeficiency virus (BaL) envelope glycoprotein 120 2008-08-15 2009-08-18 Honda, M.,Wang, R.,Kong, W.P.,Kanekiyo, M.,Akahata, W.,Xu, L.,Matsuo, K.,Natarajan, K.,Robinson, H.,Asher, T.E.,Price, D.A.,Douek, D.C.,Margulies, D.H.,Nabel, G.J. Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity J.Immunol. 2009 183 2425 2434 3E6H 19620307 MHC CLASS I H-2Dd heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PI10, from the human immunodeficiency virus (BaL) envelope glycoprotein 120 2008-08-15 2009-08-18 Honda, M.,Wang, R.,Kong, W.P.,Kanekiyo, M.,Akahata, W.,Xu, L.,Matsuo, K.,Natarajan, K.,Robinson, H.,Asher, T.E.,Price, D.A.,Douek, D.C.,Margulies, D.H.,Nabel, G.J. Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity J.Immunol. 2009 183 2425 2434 3F7F 19706512 Structure of Nup120 2008-11-08 2009-08-18 Seo, H.S.,Ma, Y.,Debler, E.W.,Wacker, D.,Kutik, S.,Blobel, G.,Hoelz, A. Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc.Natl.Acad.Sci.USA 2009 106 14281 14286 3GQL 19665973 Crystal Structure of activated receptor tyrosine kinase in complex with substrates 2009-03-24 2009-08-18 Bae, J.H.,Lew, E.D.,Yuzawa, S.,Tome, F.,Lax, I.,Schlessinger, J. The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell(Cambridge,Mass.) 2009 138 514 524 3HUS 19650644 Crystal structure of recombinant gamma N308K fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide 2009-06-15 2009-08-18 Bowley, S.R.,Okumura, N.,Lord, S.T. Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and ""A:a"" interactions. Biochemistry 2009 48 8656 8663 3HV9 19679088 Crystal structure of FimX EAL domain from Pseudomonas aeruginosa 2009-06-15 2009-08-18 Navarro, M.V.,De, N.,Bae, N.,Wang, Q.,Sondermann, H. Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure 2009 17 1104 1116 3IJ6 CRYSTAL STRUCTURE OF AN UNCHARACTERIZED METAL-DEPENDENT HYDROLASE FROM Lactobacillus acidophilus 2009-08-03 2009-08-18 Patskovsky, Y.,Toro, R.,Dickey, M.,Chang, S.,Sauder, J.M.,Raushel, F.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF AN UNCHARACTERIZED METAL-DEPENDENT HYDROLASE FROM Lactobacillus acidopphilus To be Published 0 0 0 0 3IK4 22392983 CRYSTAL STRUCTURE OF mandelate racemase/muconate lactonizing protein from Herpetosiphon aurantiacus 2009-08-05 2009-08-18 Lukk, T.,Sakai, A.,Kalyanaraman, C.,Brown, S.D.,Imker, H.J.,Song, L.,Fedorov, A.A.,Fedorov, E.V.,Toro, R.,Hillerich, B.,Seidel, R.,Patskovsky, Y.,Vetting, M.W.,Nair, S.K.,Babbitt, P.C.,Almo, S.C.,Gerlt, J.A.,Jacobson, M.P. Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proc.Natl.Acad.Sci.USA 2012 109 4122 4127 3ILV Crystal structure of a glutamine-dependent NAD(+) synthetase from Cytophaga hutchinsonii 2009-08-07 2009-08-18 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of a glutamine-dependent NAD(+) synthetase from Cytophaga hutchinsonii To be Published 0 0 0 0 3IMH CRYSTAL STRUCTURE OF GALACTOSE 1-EPIMERASE FROM Lactobacillus acidophilus NCFM 2009-08-10 2009-08-18 Patskovsky, Y.,Toro, R.,Dickey, M.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF GALACTOSE 1-EPIMERASE FROM Lactobacillus acidophilus To be Published 0 0 0 0 3E4B 20159471 Crystal structure of AlgK from Pseudomonas fluorescens WCS374r 2008-08-11 2009-08-25 Keiski, C.L.,Harwich, M.,Jain, S.,Neculai, A.M.,Yip, P.,Robinson, H.,Whitney, J.C.,Riley, L.,Burrows, L.L.,Ohman, D.E.,Howell, P.L. AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin. Structure 2010 18 265 273 3IPL CRYSTAL STRUCTURE OF o-succinylbenzoic acid-CoA ligase FROM Staphylococcus aureus subsp. aureus Mu50 2009-08-17 2009-08-25 Patskovsky, Y.,Toro, R.,Dickey, M.,Sauder, J.M.,Chang, S.,Burley, S.K.,Almo, S.C. Crystal structure of o-succinylbenzoic acid-CoA ligase from Staphylococcus aureus To be Published 0 0 0 0 3IRS CRYSTAL STRUCTURE OF UNCHARACTERIZED TIM-BARREL PROTEIN BB4693 FROM Bordetella bronchiseptica 2009-08-24 2009-09-01 Patskovsky, Y.,Malashkevich, V.,Toro, R.,Foti, R.,Dickey, M.,Sauder, J.M.,Raushel, F.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF UNCHARACTERIZED HYDROLASE FROM Bordetella bronchiseptica To be Published 0 0 0 0 3IRV CRYSTAL STRUCTURE OF CYSTEINE HYDROLASE PSPPH_2384 FROM Pseudomonas syringae pv. phaseolicola 1448A 2009-08-24 2009-09-01 Patskovsky, Y.,Malashkevich, V.,Toro, R.,Foti, R.,Dickey, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF CYSTEINE HYDROLASE PSPPH_2384 FROM Pseudomonas syringae To be Published 0 0 0 0 3ISA CRYSTAL STRUCTURE OF putative enoyl-CoA hydratase/isomerase FROM Bordetella parapertussis 2009-08-25 2009-09-01 Patskovsky, Y.,Malashkevich, V.,Toro, R.,Foti, R.,Dickey, M.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF enoyl-CoA hydratase FROM Bordetella parapertussis To be Published 0 0 0 0 3EEI Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A 2008-09-04 2009-09-08 Ho, M.,Rinaldo-matthis, A.,Brown, R.L.,Norris, G.E.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A To be Published 0 0 0 0 3ID9 Crystal structure of a MutT/NUDIX family protein from Bacillus thuringiensis 2009-07-20 2009-09-08 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of a MutT/NUDIX family protein from Bacillus thuringiensis To be Published 0 0 0 0 3IH0 Crystal structure of an uncharacterized sugar kinase PH1459 from Pyrococcus horikoshii in complex with AMP-PNP 2009-07-29 2009-09-08 Kumar, G.,Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of an uncharacterized sugar kinase PH1459 from Pyrococcus horikoshii in complex with AMP-PNP To be Published 0 0 0 0 3IPI Crystal Structure of a Geranyltranstransferase from the Methanosarcina mazei 2009-08-17 2009-09-08 Kumaran, D.,Mohammed, M.B.,Brown, A.,Burley, S.K.,Swaminathan, S. Crystal Structure of a Geranyltranstransferase from the Methanosarcina mazei To be Published 0 0 0 0 3IVR CRYSTAL STRUCTURE OF PUTATIVE long-chain-fatty-acid CoA ligase FROM Rhodopseudomonas palustris CGA009 2009-09-01 2009-09-08 Patskovsky, Y.,Toro, R.,Foti, R.,Dickey, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF PUTATIVE long-chain-fatty-acid CoA SYNTHASE FROM Rhodopseudomonas palustris CGA009 To be Published 0 0 0 0 3H6F 19759536 Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor HT1171 2009-04-23 2009-09-15 Lin, G.,Li, D.,de Carvalho, L.P.,Deng, H.,Tao, H.,Vogt, G.,Wu, K.,Schneider, J.,Chidawanyika, T.,Warren, J.D.,Li, H.,Nathan, C. Inhibitors selective for mycobacterial versus human proteasomes. Nature 2009 461 621 626 3H6I 19759536 Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor GL1 2009-04-23 2009-09-15 Lin, G.,Li, D.,de Carvalho, L.P.,Deng, H.,Tao, H.,Vogt, G.,Wu, K.,Schneider, J.,Chidawanyika, T.,Warren, J.D.,Li, H.,Nathan, C. Inhibitors selective for mycobacterial versus human proteasomes. Nature 2009 461 621 626 3H77 19694421 Crystal structure of Pseudomonas aeruginosa PqsD in a covalent complex with anthranilate 2009-04-24 2009-09-15 Bera, A.K.,Atanasova, V.,Robinson, H.,Eisenstein, E.,Coleman, J.P.,Pesci, E.C.,Parsons, J.F. Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate. Biochemistry 2009 48 8644 8655 3H78 19694421 Crystal structure of Pseudomonas aeruginosa PqsD C112A mutant in complex with anthranilic acid 2009-04-24 2009-09-15 Bera, A.K.,Atanasova, V.,Robinson, H.,Eisenstein, E.,Coleman, J.P.,Pesci, E.C.,Parsons, J.F. Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate. Biochemistry 2009 48 8644 8655 3HF9 19759536 Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant modified by inhibitor GL1 2009-05-11 2009-09-15 Lin, G.,Li, D.,de Carvalho, L.P.,Deng, H.,Tao, H.,Vogt, G.,Wu, K.,Schneider, J.,Chidawanyika, T.,Warren, J.D.,Li, H.,Nathan, C. Inhibitors selective for mycobacterial versus human proteasomes. Nature 2009 461 621 626 3HFA 19759536 Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant 2009-05-11 2009-09-15 Lin, G.,Li, D.,de Carvalho, L.P.,Deng, H.,Tao, H.,Vogt, G.,Wu, K.,Schneider, J.,Chidawanyika, T.,Warren, J.D.,Li, H.,Nathan, C. Inhibitors selective for mycobacterial versus human proteasomes. Nature 2009 461 621 626 3EWD 19728741 Crystal structure of adenosine deaminase mutant (delta Asp172) from Plasmodium vivax in complex with MT-coformycin 2008-10-14 2009-09-22 Ho, M.C.,Cassera, M.B.,Madrid, D.C.,Ting, L.M.,Tyler, P.C.,Kim, K.,Almo, S.C.,Schramm, V.L. Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry 2009 48 9618 9626 3IAY 19718023 Ternary complex of DNA polymerase delta 2009-07-15 2009-09-22 Swan, M.K.,Johnson, R.E.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta Nat.Struct.Mol.Biol. 2009 16 979 986 3JU2 CRYSTAL STRUCTURE OF PROTEIN SMc04130 FROM Sinorhizobium meliloti 1021 2009-09-14 2009-09-22 Patskovsky, Y.,Foti, R.,Ramagopal, U.,Malashkevich, V.,Freeman, J.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF PROTEIN SMc04130 FROM Sinorhizobium meliloti To be Published 0 0 0 0 3JVD Crystal structure of putative transcription regulation repressor (LACI family) FROM Corynebacterium glutamicum 2009-09-16 2009-09-22 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Foti, R.,Freeman, J.,Do, J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of LACI family protein from Corynebacterium glutamicum To be Published 0 0 0 0 3IP1 Structure of putative alcohol dehydrogenase (TM_042) from Thermotoga maritima 2009-08-15 2009-09-29 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of putative alcohol dehydrogenase (TM_042) from Thermotoga maritima To be published 0 0 0 0 3IP3 Structure of putative oxidoreductase (TM_0425) from Thermotoga maritima 2009-08-16 2009-09-29 Ramagopal, U.A.,Morano, C.,Burley, S.K.,Almo, S.C. Structure of putative oxidoreductase (TM_0425) from Thermotoga maritima To be Published 0 0 0 0 3IVD Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine 2009-08-31 2009-09-29 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine To be Published 0 0 0 0 3IVE Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Cytidine 2009-08-31 2009-09-29 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Cytidine To be Published 0 0 0 0 3F0Q 20643959 Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine 2008-10-25 2009-10-06 Frey, K.M.,Georgiev, I.,Donald, B.R.,Anderson, A.C. Predicting resistance mutations using protein design algorithms. Proc.Natl.Acad.Sci.USA 2010 107 13707 13712 3F0S Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine 2008-10-25 2009-10-06 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Crystallographic Complexes of Wildtype and Mutant MRSA DHFR Reveal Interactions for Lead Design To be Published 0 0 0 0 3F0V Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine 2008-10-26 2009-10-06 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Crystallographic Complexes of Wildtype and Mutant MRSA DHFR Reveal Interactions for Lead Design To be Published 0 0 0 0 3F0X Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine 2008-10-27 2009-10-06 Frey, K.M.,Liu, J.,Lombardo, M.N.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Crystallographic Complexes of Wildtype and Mutant MRSA DHFR Reveal Interactions for Lead Design To be Published 0 0 0 0 3IJN 5-SeMe-Cytidine modified DNA 8mer 2009-08-04 2009-10-06 Sheng, J.,Zhang, W.,Hassan, A.E.A.,Gan, J.,Huang, Z. 5-SeMe-Cytidine modified DNA 8mer TO BE PUBLISHED 0 0 0 0 3K17 Crystal structure of a Lin0012 protein from Listeria innocua 2009-09-25 2009-10-06 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of a Lin0012 protein from Listeria innocua To be Published 0 0 0 0 3JY6 Crystal structure of LacI Transcriptional regulator from Lactobacillus brevis 2009-09-21 2009-10-13 Syed Ibrahim, B.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of LacI Transcriptional regulator from Lactobacillus brevis To be Published 0 0 0 0 3JYG Crystal structure of uncharacterized protein WS1659 from Wolinella succinogenes 2009-09-21 2009-10-13 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of uncharacterized protein WS1659 from Wolinella succinogenes To be published 0 0 0 0 3JZV Crystal structure of Rru_A2000 from Rhodospirillum rubrum: A cupin-2 domain. 2009-09-24 2009-10-13 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of Rru_A2000 from Rhodospirillum rubrum: A cupin-2 domain. To be Published 0 0 0 0 3K2G Crystal structure of a Resiniferatoxin-binding protein from Rhodobacter sphaeroides 2009-09-30 2009-10-13 Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a Resiniferatoxin-binding protein from Rhodobacter sphaeroides To be Published 0 0 0 0 3K4I CRYSTAL STRUCTURE OF uncharacterized protein PSPTO_3204 from Pseudomonas syringae pv. tomato str. DC3000 2009-10-05 2009-10-13 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF uncharacterized protein PSPTO_3204 from Pseudomonas syringae pv. tomato str. DC3000 To be Published 0 0 0 0 3H8B 19761244 A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 9) 2009-04-29 2009-10-20 Shenoy, R.T.,Chowdhury, S.F.,Kumar, S.,Joseph, L.,Purisima, E.O.,Sivaraman, J. A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors J.Med.Chem. 2009 52 6335 6346 3HQT 19838203 PLP-Dependent Acyl-CoA Transferase CqsA 2009-06-08 2009-10-20 Kelly, R.C.,Bolitho, M.E.,Higgins, D.A.,Lu, W.,Ng, W.L.,Jeffrey, P.D.,Rabinowitz, J.D.,Semmelhack, M.F.,Hughson, F.M.,Bassler, B.L. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol. 2009 5 891 895 3JUX 19850053 Structure of the translocation ATPase SecA from Thermotoga maritima 2009-09-15 2009-10-20 Zimmer, J.,Rapoport, T.A. Conformational flexibility and peptide interaction of the translocation ATPase SecA. J.Mol.Biol. 2009 394 606 612 3K2W CRYSTAL STRUCTURE OF betaine-aldehyde dehydrogenase FROM Pseudoalteromonas atlantica T6c 2009-09-30 2009-10-20 Patskovsky, Y.,Toro, R.,Rutter, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF betaine-aldehyde dehydrogenase FROM Pseudoalteromonas atlantica To be Published 0 0 0 0 3FP9 19836337 Crystal structure of Intern Domain of proteasome-associated ATPase, Mycobacterium tuberculosis 2009-01-04 2009-10-27 Wang, T.,Li, H.,Lin, G.,Tang, C.,Li, D.,Nathan, C.,Darwin, K.H.,Li, H. Structural Insights on the Mycobacterium tuberculosis Proteasomal ATPase Mpa. Structure 2009 17 1377 1385 3FP9 19836337 Crystal structure of Intern Domain of proteasome-associated ATPase, Mycobacterium tuberculosis 2009-01-04 2009-10-27 Wang, T.,Li, H.,Lin, G.,Tang, C.,Li, D.,Nathan, C.,Darwin, K.H.,Li, H. Structural Insights on the Mycobacterium tuberculosis Proteasomal ATPase Mpa. Structure 2009 17 1377 1385 3IN0 19890331 Crystal structure of the F114P/M121Q variant of Pseudomonas aeruginosa azurin in the Cu(II) state 2009-08-11 2009-10-27 Marshall, N.M.,Garner, D.K.,Wilson, T.D.,Gao, Y.G.,Robinson, H.,Nilges, M.J.,Lu, Y. Rationally tuning the reduction potential of a single cupredoxin beyond the natural range. Nature 2009 462 113 116 3K10 19884503 Crystal structure of telomere capping protein Stn1 from Saccharomyces cerevisiae 2009-09-25 2009-10-27 Gelinas, A.D.,Paschini, M.,Reyes, F.E.,Heroux, A.,Batey, R.T.,Lundblad, V.,Wuttke, D.S. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proc.Natl.Acad.Sci.USA 2009 106 19298 19303 3K12 Crystal structure of an uncharacterized protein A6V7T0 from Pseudomonas aeruginosa 2009-09-25 2009-10-27 Ho, M.,Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of an uncharacterized protein A6V7T0 from Pseudomonas aeruginosa To be published 0 0 0 0 3K9D CRYSTAL STRUCTURE OF PROBABLE ALDEHYDE DEHYDROGENASE FROM Listeria monocytogenes EGD-e 2009-10-15 2009-10-27 Patskovsky, Y.,Toro, R.,Freeman, J.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Aldehyde Dehydrogenase from Listeria Monocytogenes To be Published 0 0 0 0 3FCJ 19926855 Nitroalkane oxidase: mutant402N crystallized with nitroethane 2008-11-21 2009-11-03 Major, D.T.,Heroux, A.,Orville, A.M.,Valley, M.P.,Fitzpatrick, P.F.,Gao, J. Differential quantum tunneling contributions in nitroalkane oxidase catalyzed and the uncatalyzed proton transfer reaction. Proc.Natl.Acad.Sci.USA 2009 106 20734 20739 3G8S 19228039 Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme 2009-02-12 2009-11-03 Cochrane, J.C.,Lipchock, S.V.,Smith, K.D.,Strobel, S.A. Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme Biochemistry 2009 48 3239 3246 3G8T 19228039 Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P 2009-02-12 2009-11-03 Cochrane, J.C.,Lipchock, S.V.,Smith, K.D.,Strobel, S.A. Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme Biochemistry 2009 48 3239 3246 3G96 19228039 Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P 2009-02-12 2009-11-03 Cochrane, J.C.,Lipchock, S.V.,Smith, K.D.,Strobel, S.A. Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme Biochemistry 2009 48 3239 3246 3G9C 19228039 Crystal structure of the product Bacillus anthracis glmS ribozyme 2009-02-13 2009-11-03 Cochrane, J.C.,Lipchock, S.V.,Smith, K.D.,Strobel, S.A. Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme Biochemistry 2009 48 3239 3246 3JR5 19889642 MutM lesion recognition control complex with N174C crosslinking site 2009-09-08 2009-11-03 Qi, Y.,Spong, M.C.,Nam, K.,Karplus, M.,Verdine, G.L. Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM. J.Biol.Chem. 2010 285 1468 1478 3JRM 19889631 Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator 2009-09-08 2009-11-03 Stadtmueller, B.M.,Ferrell, K.,Whitby, F.G.,Heroux, A.,Robinson, H.,Myszka, D.G.,Hill, C.P. Structural models for interactions between the 20S proteasome and its PAN/19S activators. J.Biol.Chem. 2010 285 13 17 3JTL 19889631 Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator 2009-09-12 2009-11-03 Stadtmueller, B.M.,Ferrell, K.,Whitby, F.G.,Heroux, A.,Robinson, H.,Myszka, D.G.,Hill, C.P. Structural Models for Interactions between the 20S proteasome and its PAN/19S activators. J.Biol.Chem. 2010 285 13 17 3K4U CRYSTAL STRUCTURE OF putative binding component of ABC transporter from Wolinella succinogenes DSM 1740 complexed with lysine 2009-10-06 2009-11-03 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative binding component of ABC transporter from Wolinella succinogenes DSM 1740 complexed with lysine To be Published 0 0 0 0 3K7V 19916524 Protein phosphatase 2A core complex bound to dinophysistoxin-1 2009-10-13 2009-11-03 Huhn, J.,Jeffrey, P.D.,Larsen, K.,Rundberget, T.,Rise, F.,Cox, N.R.,Arcus, V.,Shi, Y.,Miles, C.O. A structural basis for the reduced toxicity of dinophysistoxin-2. Chem.Res.Toxicol. 2009 22 1782 1786 3K7W 19916524 Protein phosphatase 2A core complex bound to dinophysistoxin-2 2009-10-13 2009-11-03 Huhn, J.,Jeffrey, P.D.,Larsen, K.,Rundberget, T.,Rise, F.,Cox, N.R.,Arcus, V.,Shi, Y.,Miles, C.O. A structural basis for the reduced toxicity of dinophysistoxin-2. Chem.Res.Toxicol. 2009 22 1782 1786 3K9C Crystal structure of LacI Transcriptional regulator from Rhodococcus species. 2009-10-15 2009-11-03 Damodhran, L.,Burley, S.K.,Swaminathan, S. Crystal structure of LacI Transcriptional regulator from Rhodococcus species. To be Published 0 0 0 0 3KEW Crystal structure of probable alanyl-trna-synthase from Clostridium perfringens 2009-10-26 2009-11-03 Patskovsky, Y.,Toro, R.,Gilmore, M.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of alanyl-trna-synthase from Clostridium perfringens To be Published 0 0 0 0 3GPP 20010681 MutM encountering an intrahelical 8-oxoguanine (oxoG) lesion in EC3-T224P complex 2009-03-23 2009-11-10 Qi, Y.,Spong, M.C.,Nam, K.,Banerjee, A.,Jiralerspong, S.,Karplus, M.,Verdine, G.L. Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature 2009 462 762 766 3IRW 19898477 Structure of a c-di-GMP riboswitch from V. cholerae 2009-08-24 2009-11-10 Smith, K.D.,Lipchock, S.V.,Ames, T.D.,Wang, J.,Breaker, R.R.,Strobel, S.A. Structural basis of ligand binding by a c-di-GMP riboswitch. Nat.Struct.Mol.Biol. 2009 16 1218 1223 3K4H CRYSTAL STRUCTURE OF putative transcriptional regulator LacI from Bacillus cereus subsp. cytotoxis NVH 391-98 2009-10-05 2009-11-10 Malashkevich, V.N.,Toro, R.,Morano, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative transcriptional regulator LacI from Bacillus cereus subsp. cytotoxis NVH 391-98 To be Published 0 0 0 0 3K6B 19906646 X-ray crystal structure of the E2 domain of APL-1 from C. elegans, in complex with sucrose octasulfate (SOS) 2009-10-08 2009-11-10 Hoopes, J.T.,Liu, X.,Xu, X.,Demeler, B.,Folta-Stogniew, E.,Li, C.,Ha, Y. Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site J.Biol.Chem. 2010 285 2165 2173 3K8P 20005805 Structural basis for vesicle tethering by the Dsl1 complex 2009-10-14 2009-11-10 Ren, Y.,Yip, C.K.,Tripathi, A.,Huie, D.,Jeffrey, P.D.,Walz, T.,Hughson, F.M. A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell(Cambridge,Mass.) 2009 139 1119 1129 3KD9 Crystal structure of pyridine nucleotide disulfide oxidoreductase from Pyrococcus horikoshii 2009-10-22 2009-11-10 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of pyridine nucleotide disulfide oxidoreductase from Pyrococcus horikoshii To be Published 0 0 0 0 3IN2 19890331 Crystal structure of the N47S/M121L variant of Pseudomonas aeruginosa azurin in the Cu(II) state 2009-08-11 2009-11-17 Marshall, N.M.,Garner, D.K.,Wilson, T.D.,Gao, Y.G.,Robinson, H.,Nilges, M.J.,Lu, Y. Rationally tuning the reduction potential of a single cupredoxin beyond the natural range. Nature 2009 462 113 116 3K3F 19865084 Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris 2009-10-02 2009-11-17 Levin, E.J.,Quick, M.,Zhou, M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature 2009 462 757 761 3K3F 19865084 Crystal Structure of the Urea Transporter from Desulfovibrio Vulgaris 2009-10-02 2009-11-17 Levin, E.J.,Quick, M.,Zhou, M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature 2009 462 757 761 3KCN The crystal structure of adenylate cyclase from Rhodopirellula baltica 2009-10-21 2009-11-17 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of adenylate cyclase from Rhodopirellula baltica To be Published 0 0 0 0 3KCT 19934036 CRYSTAL STRUCTURE OF PAmCherry1 in the photoactivated state 2009-10-21 2009-11-17 Subach, F.V.,Malashkevich, V.N.,Zencheck, W.D.,Xiao, H.,Filonov, G.S.,Almo, S.C.,Verkhusha, V.V. Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states. Proc.Natl.Acad.Sci.USA 2009 106 21097 21102 3KIO 19923215 mouse RNase H2 complex 2009-11-02 2009-11-17 Shaban, N.M.,Harvey, S.,Perrino, F.W.,Hollis, T. The structure of the mammalian RNase H2 complex provides insight into RNA:DNA hybrid processing to prevent immune dysfunction. J.Biol.Chem. 2010 285 3617 3624 3INM 19935646 Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+) 2009-08-12 2009-11-24 Dang, L.,White, D.W.,Gross, S.,Bennett, B.D.,Bittinger, M.A.,Driggers, E.M.,Fantin, V.R.,Jang, H.G.,Jin, S.,Keenan, M.C.,Marks, K.M.,Prins, R.M.,Ward, P.S.,Yen, K.E.,Liau, L.M.,Rabinowitz, J.D.,Cantley, L.C.,Thompson, C.B.,Vander Heiden, M.G.,Su, S.M. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009 462 739 744 3KKI 19838203 PLP-Dependent Acyl-CoA transferase CqsA 2009-11-05 2009-11-24 Kelly, R.C.,Bolitho, M.E.,Higgins, D.A.,Lu, W.,Ng, W.L.,Jeffrey, P.D.,Rabinowitz, J.D.,Semmelhack, M.F.,Hughson, F.M.,Bassler, B.L. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol. 2009 5 891 895 3KOL Crystal structure of a glyoxalase/dioxygenase from Nostoc punctiforme 2009-11-13 2009-11-24 Eswaramoorthy, S.,Burley, S.K.,Swaminathan, S. Crystal structure of a glyoxalase/dioxygenase from Nostoc punctiforme To be Published 0 0 0 0 3KHN Crystal structure of putative MotB like protein DVU_2228 from Desulfovibrio vulgaris. 2009-10-30 2009-12-01 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of putative MotB like protein DVU_2228 from Desulfovibrio vulgaris To be Published 0 0 0 0 3KSU Crystal structure of short-chain dehydrogenase from oenococcus oeni psu-1 2009-11-23 2009-12-01 Patskovsky, Y.,Toro, R.,Gilmore, M.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Short-Chain Dehydrogenase from Oenococcus Oeni Psu-1 To be Published 0 0 0 0 3HIO 19920175 Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue 2009-05-20 2009-12-08 Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA 2009 106 20276 20281 3HIQ 19920175 Crystal structure of Saporin-L1 mutant (Y73A) from Saponaria officinalis 2009-05-20 2009-12-08 Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA 2009 106 20276 20281 3HIS 19920175 Crystal structure of Saporin-L1 from Saponaria officinalis 2009-05-20 2009-12-08 Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA 2009 106 20276 20281 3HIV 19920175 Crystal structure of Saporin-L1 in complex with the trinucleotide inhibitor, a transition state analogue 2009-05-20 2009-12-08 Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA 2009 106 20276 20281 3HIW 19920175 Crystal structure of Saporin-L1 in complex with the cyclic tetranucleotide inhibitor, a transition state analogue 2009-05-20 2009-12-08 Ho, M.C.,Sturm, M.B.,Almo, S.C.,Schramm, V.L. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA 2009 106 20276 20281 3IEC 19966800 Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates 2009-07-22 2009-12-08 Nesic, D.,Miller, M.C.,Quinkert, Z.T.,Stein, M.,Chait, B.T.,Stebbins, C.E. Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates. Nat.Struct.Mol.Biol. 2010 17 130 132 3K5W Crystal structure of a Carbohydrate kinase (YjeF family)from Helicobacter pylori 2009-10-08 2009-12-08 Satyanarayana, L.,Burley, S.K.,Swaminathan, S. Crystal structure of a Carbohydrate kinase (YjeF family)from Helicobacter pylori To be Published 0 0 0 0 3K85 Crystal structure of a D-glycero-D-manno-heptose 1-phosphate kinase from Bacteriodes thetaiotaomicron 2009-10-13 2009-12-08 Palani, K.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a D-glycero-D-manno-heptose 1-phosphate kinase from Bacteriodes thetaiotaomicron To be Published 0 0 0 0 3KFC 19932617 Complex Structure of LXR with an agonist 2009-10-27 2009-12-08 Bernotas, R.C.,Singhaus, R.R.,Kaufman, D.H.,Travins, J.M.,Ullrich, J.W.,Unwalla, R.,Quinet, E.,Evans, M.,Nambi, P.,Olland, A.,Kauppi, B.,Wilhelmsson, A.,Goos-Nilsson, A.,Wrobel, J. 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg.Med.Chem.Lett. 2010 20 209 212 3KTS CRYSTAL STRUCTURE OF GLYCEROL UPTAKE OPERON ANTITERMINATOR REGULATORY PROTEIN FROM LISTERIA MONOCYTOGENES STR. 4b F2365 2009-11-25 2009-12-08 Patskovsky, Y.,Toro, R.,Freeman, J.,Do, J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF GLYCEROL UPTAKE OPERON ANTITERMINATOR REGULATORY PROTEIN FROM LISTERIA MONOCYTOGENES STR. 4b F2365 To be Published 0 0 0 0 3KRT CRYSTAL STRUCTURE OF putative crotonyl CoA reductase from Streptomyces coelicolor A3(2) 2009-11-19 2009-12-15 Malashkevich, V.N.,Patskovsky, Y.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative crotonyl CoA reductase from Streptomyces coelicolor A3(2) To be Published 0 0 0 0 3KTF Structure of the N-terminal BRCT domain of human microcephalin (MCPH1). 2009-11-25 2009-12-15 Singh, N.,Heroux, A.,Thompson, J.R.,Mer, G. Structure of N-terminal BRCT domain of human microcephalin (MCPH1) To be Published 0 0 0 0 3KTO Crystal structure of response regulator receiver protein from Pseudoalteromonas atlantica 2009-11-25 2009-12-15 Damodharan, L.,Burley, S.K.,Swaminathan, S. Crystal structure of response regulator receiver protein from Pseudoalteromonas atlantica To be Published 0 0 0 0 3KZG Crystal structure of an arginine 3rd transport system periplasmic binding protein from Legionella pneumophila 2009-12-08 2009-12-22 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of an arginine 3rd transport system periplasmic binding protein from Legionella pneumophila To be Published 0 0 0 0 3KZH Crystal structure of a putative sugar kinase from Clostridium perfringens 2009-12-08 2009-12-22 Syed Ibrahim, B.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative sugar kinase from Clostridium perfringens To be Published 0 0 0 0 3FOW 24416224 Plasmodium Purine Nucleoside Phosphorylase V66I-V73I-Y160F Mutant 2009-01-02 2009-12-29 Donaldson, T.M.,Ting, L.M.,Zhan, C.,Shi, W.,Zheng, R.,Almo, S.C.,Kim, K. Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase. Plos One 2014 9 0 0 3L3S Crystal structure of an enoyl-CoA hydrotase/isomerase family protein from Silicibacter pomeroyi 2009-12-17 2010-01-05 Eswaramoorthy, S.,Silberstein, M.,Burley, S.K.,Swaminathan, S. Crystal structure of an enoyl-CoA hydrotase/isomerase family protein from Silicibacter pomeroyi To be Published 0 0 0 0 3L60 Crystal structure of branched-chain alpha-keto acid dehydrogenase subunit e2 from mycobacterium tuberculosis 2009-12-22 2010-01-05 Zencheck, W.D.,Bonanno, J.B.,Patskovsky, Y.,Toro, R.,Freeman, J.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Branched-Chain Alpha-Keto Acid Dehydrogenase Subunit E2 from Mycobacterium Tuberculosis To be Published 0 0 0 0 3FOM 20093428 Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide IQQSIERL 2008-12-30 2010-01-12 Brims, D.R.,Qian, J.,Jarchum, I.,Mikesh, L.,Palmieri, E.,Ramagopal, U.A.,Malashkevich, V.N.,Chaparro, R.J.,Lund, T.,Hattori, M.,Shabanowitz, J.,Hunt, D.F.,Nathenson, S.G.,Almo, S.C.,Dilorenzo, T.P. Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect. Int.Immunol. 2010 22 191 203 3FON 20093428 Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide VNDIFEAI 2008-12-30 2010-01-12 Brims, D.R.,Qian, J.,Jarchum, I.,Mikesh, L.,Palmieri, E.,Ramagopal, U.A.,Malashkevich, V.N.,Chaparro, R.J.,Lund, T.,Hattori, M.,Shabanowitz, J.,Hunt, D.F.,Nathenson, S.G.,Almo, S.C.,Dilorenzo, T.P. Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect. Int.Immunol. 2010 22 191 203 3GX5 20006621 Crystal structure of T. tencongensis SAM-I riboswitch variant A94G/U34 bound with SAM 2009-04-01 2010-01-12 Montange, R.K.,Mondragon, E.,van Tyne, D.,Garst, A.D.,Ceres, P.,Batey, R.T. Discrimination between Closely Related Cellular Metabolites by the SAM-I Riboswitch. J.Mol.Biol. 2010 396 761 772 3KHB 20084272 Crystal structure of Escherichia coli AlkB with Co(II) and 2-OG 2009-10-30 2010-01-12 Holland, P.J.,Hollis, T. Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching. Plos One 2010 5 0 0 3L6D Crystal structure of putative oxidoreductase from Pseudomonas putida KT2440 2009-12-23 2010-01-12 Malashkevich, V.N.,Patskovsky, Y.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative oxidoreductase from Pseudomonas putida KT2440 To be Published 0 0 0 0 3HLS 20105301 Crystal structure of the signaling helix coiled-coil doimain of the BETA-1 subunit of the soluble guanylyl cyclase 2009-05-28 2010-01-19 Ma, X.,Beuve, A.,van den Akker, F. Crystal structure of the signaling helix coiled-coil domain of the beta-1 subunit of the soluble guanylyl cyclase. Bmc Struct.Biol. 2010 10 2 2 3IOY Structure of putative short-chain dehydrogenase (Saro_0793) from Novosphingobium aromaticivorans 2009-08-15 2010-01-19 Ramagopal, U.A.,Morano, C.,Burley, S.K.,Almo, S.C. Structure of putative short-chain dehydrogenase (Saro_0793) from Novosphingobium aromaticivorans To be published 0 0 0 0 3IVN 20022916 Structure of the U65C mutant A-riboswitch aptamer from the Bacillus subtilis pbuE operon 2009-09-01 2010-01-19 Delfosse, V.,Bouchard, P.,Bonneau, E.,Dagenais, P.,Lemay, J.F.,Lafontaine, D.A.,Legault, P. Riboswitch structure: an internal residue mimicking the purine ligand. Nucleic Acids Res. 2010 38 2057 2068 3KHK Crystal structure of type-I restriction-modification system methylation subunit (MM_0429) from Methanosarchina mazei. 2009-10-30 2010-01-19 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of type-I restriction-modification system methylation subunit (MM_0429) from Methanosarchina mazei. To be Published 0 0 0 0 3KW2 Crystal structure of probable rRNA-methyltransferase from Porphyromonas gingivalis 2009-11-30 2010-01-19 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of probable rRNA-methyltransferase from Porphyromonas gingivalis To be Published 0 0 0 0 3L8C Structure of probable D-alanine--poly(phosphoribitol) ligase subunit-1 from Streptococcus pyogenes 2009-12-30 2010-01-19 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of probable D-alanine--poly(phosphoribitol) ligase subunit-1 from Streptococcus pyogenes To be Published 0 0 0 0 3GV3 20077567 CXCL12 (SDF) in trigonal space group 2009-03-30 2010-01-26 Murphy, J.W.,Yuan, H.,Kong, Y.,Xiong, Y.,Lolis, E.J. Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family. Proteins 2009 78 1331 1337 3HP3 20077567 Crystal structure of CXCL12 2009-06-03 2010-01-26 Murphy, J.W.,Yuan, H.,Kong, Y.,Xiong, Y.,Lolis, E.J. Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family Proteins 2009 78 1331 1337 3IAB 20075859 Crystal structure of RNase P /RNase MRP proteins Pop6, Pop7 in a complex with the P3 domain of RNase MRP RNA 2009-07-13 2010-01-26 Perederina, A.,Esakova, O.,Quan, C.,Khanova, E.,Krasilnikov, A.S. Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain Embo J. 2010 29 761 769 3KQH 20080715 Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 2009-11-17 2010-01-26 Gu, M.,Rice, C.M. Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA 2010 107 521 528 3KQK 20080715 Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 2009-11-17 2010-01-26 Gu, M.,Rice, C.M. Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA 2010 107 521 528 3KQL 20080715 Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 2009-11-17 2010-01-26 Gu, M.,Rice, C.M. Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA 2010 107 521 528 3KQN 20080715 Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 2009-11-17 2010-01-26 Gu, M.,Rice, C.M. Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA 2010 107 521 528 3KQU 20080715 Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism 2009-11-17 2010-01-26 Gu, M.,Rice, C.M. Inaugural Article: Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA 2010 107 521 528 3IK5 20124696 SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80) 2009-08-05 2010-02-02 Kim, W.M.,Sigalov, A.B.,Stern, L.J. Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr.,Sect.D 2010 66 163 175 3IOZ 20124696 SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93) 2009-08-15 2010-02-02 Kim, W.M.,Sigalov, A.B.,Stern, L.J. Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr.,Sect.D 2010 66 163 175 3K40 20098687 Crystal structure of Drosophila 3,4-dihydroxyphenylalanine decarboxylase 2009-10-05 2010-02-02 Han, Q.,Ding, H.,Robinson, H.,Christensen, B.M.,Li, J. Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase Plos One 2010 5 0 0 3L8H 20050614 Crystal Structure of D,D-heptose 1.7-bisphosphate phosphatase from B. bronchiseptica complexed with magnesium and phosphate 2009-12-31 2010-02-02 Nguyen, H.H.,Wang, L.,Huang, H.,Peisach, E.,Dunaway-Mariano, D.,Allen, K.N. Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) . Biochemistry 2010 49 1082 1092 3LAQ 20133942 Structure-based engineering of species selectivity in the uPA-uPAR interaction 2010-01-06 2010-02-02 Lin, L.,Gardsvoll, H.,Huai, Q.,Huang, M.,Ploug, M. Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J.Biol.Chem. 2010 285 10982 10992 3LDT Crystal structure of an Outer membrane protein(OmpA)from Legionella pneumophila 2010-01-13 2010-02-02 Satyanarayana, L.,Burley, S.K.,Swaminathan, S. Crystal structure of an Outer membrane protein(OmpA)from Legionella pneumophila To be Published 0 0 0 0 3G5V 19289842 Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR 2009-02-05 2010-02-09 Garrett, T.P.J.,Burgess, A.W.,Gan, H.K.,Luwor, R.B.,Cartwright, G.,Walker, F.,Orchard, S.G.,Clayton, A.H.A.,Nice, E.C.,Rothacker, J.,Catimel, B.,Cavenee, W.K.,Old, L.J.,Stockert, E.,Ritter, G.,Adams, T.E.,Hoyne, P.A.,Wittrup, D.,Chao, G.,Cochran, J.R.,Luo, C.,Lou, M.,Huyton, T.,Xu, Y.,Fairlie, W.D.,Yao, S.,Scott, A.M.,Johns, T.G. Antibodies specifically targeting a locally misfolded region of tumor associated EGFR Proc.Natl.Acad.Sci.USA 2009 106 5082 5087 3I8A 20026215 Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B) 2009-07-09 2010-02-09 Frey, K.M.,Lombardo, M.N.,Wright, D.L.,Anderson, A.C. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. J.Struct.Biol. 2010 170 93 97 3IBA 19876942 Crystal structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with zoledronate, IPP and Mg2+ 2009-07-15 2010-02-09 Huang, C.H.,Gabelli, S.B.,Oldfield, E.,Amzel, L.M. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins 2010 78 888 899 3ICK 19876942 Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with minodronate and isopentenyl disphosphate 2009-07-17 2010-02-09 Huang, C.H.,Gabelli, S.B.,Oldfield, E.,Amzel, L.M. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins 2010 78 888 899 3ICM 19876942 Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl pyrophosphate, Mg2+ and 1-(2-Hydroxy-2,2-bis-phosphono-ethyl)-3-phenyl-pyridinium 2009-07-17 2010-02-09 Huang, C.H.,Gabelli, S.B.,Oldfield, E.,Amzel, L.M. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins 2010 78 888 899 3ICN 19876942 Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl pyrophosphate and 3-Fluoro-1-(2-hydroxy-2,2-bis-phosphono-ethyl)-pyridinium 2009-07-17 2010-02-09 Huang, C.H.,Gabelli, S.B.,Oldfield, E.,Amzel, L.M. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins 2010 78 888 899 3KBK 20131801 Epi-isozizaene synthase complexed with Hg 2009-10-20 2010-02-09 Aaron, J.A.,Lin, X.,Cane, D.E.,Christianson, D.W. Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates Biochemistry 2010 49 1787 1797 3KLN 20150502 Vibrio cholerae VpsT 2009-11-08 2010-02-09 Krasteva, P.V.,Fong, J.C.,Shikuma, N.J.,Beyhan, S.,Navarro, M.V.,Yildiz, F.H.,Sondermann, H. Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science 2010 327 866 868 3KLN 20150502 Vibrio cholerae VpsT 2009-11-08 2010-02-09 Krasteva, P.V.,Fong, J.C.,Shikuma, N.J.,Beyhan, S.,Navarro, M.V.,Yildiz, F.H.,Sondermann, H. Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science 2010 327 866 868 3KLN 20150502 Vibrio cholerae VpsT 2009-11-08 2010-02-09 Krasteva, P.V.,Fong, J.C.,Shikuma, N.J.,Beyhan, S.,Navarro, M.V.,Yildiz, F.H.,Sondermann, H. Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science 2010 327 866 868 3KLO 20150502 Vibrio cholerae VpsT bound to c-di-GMP 2009-11-08 2010-02-09 Krasteva, P.V.,Fong, J.C.,Shikuma, N.J.,Beyhan, S.,Navarro, M.V.,Yildiz, F.H.,Sondermann, H. Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science 2010 327 866 868 3KRM 20080952 Imp1 kh34 2009-11-18 2010-02-09 Chao, J.A.,Patskovsky, Y.,Patel, V.,Levy, M.,Almo, S.C.,Singer, R.H. ZBP1 recognition of beta-actin zipcode induces RNA looping. Genes Dev. 2010 24 148 158 3L6E Crystal structure of putative short chain dehydrogenase/reductase family oxidoreductase from Aeromonas hydrophila subsp. hydrophila ATCC 7966 2009-12-23 2010-02-09 Malashkevich, V.N.,Patskovsky, Y.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative short chain dehydrogenase/reductase family oxidoreductase from Aeromonas hydrophila subsp. hydrophila ATCC 7966 To be Published 0 0 0 0 3LG5 20131801 F198A Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium cation 2010-01-19 2010-02-09 Aaron, J.A.,Lin, X.,Cane, D.E.,Christianson, D.W. Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates Biochemistry 2010 49 1787 1797 3LJI CRYSTAL STRUCTURE OF putative geranyltranstransferase from Pseudomonas fluorescens Pf-5 2010-01-26 2010-02-09 Malashkevich, V.N.,Toro, R.,Patskovsky, Y.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative geranyltranstransferase from Pseudomonas fluorescens Pf-5 To be Published 0 0 0 0 3LKB Crystal structure of a branched chain amino acid ABC transporter from Thermus thermophilus with bound valine 2010-01-27 2010-02-09 Agarwal, R.,Sauder, J.M.,Burley, S.K.,Swaminathan, S. Crystal structure of a branched chain amino acid ABC transporter from Thermus thermophilus with bound valine To be Published 0 0 0 0 3JYB 20112417 Crystal Structure of the RetS periplasmic domain 2009-09-21 2010-02-16 Jing, X.,Jaw, J.,Robinson, H.H.,Schubot, F.D. Crystal structure and oligomeric state of the RetS signaling kinase sensory domain. Proteins 2010 78 1631 1640 3K3E 20121115 Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691 2009-10-02 2010-02-16 Wang, H.,Luo, X.,Ye, M.,Hou, J.,Robinson, H.,Ke, H. Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis J.Med.Chem. 2010 53 1726 1731 3K3H 20121115 Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691 2009-10-02 2010-02-16 Wang, H.,Luo, X.,Ye, M.,Hou, J.,Robinson, H.,Ke, H. Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis J.Med.Chem. 2010 53 1726 1731 3KVQ 20080685 Crystal structure of VEGFR2 extracellular domain D7 2009-11-30 2010-02-16 Yang, Y.,Xie, P.,Opatowsky, Y.,Schlessinger, J. Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling Proc.Natl.Acad.Sci.USA 2010 107 1906 1911 3LMD Crystal structure of geranylgeranyl pyrophosphate synthase from corynebacterium glutamicum atcc 13032 2010-01-29 2010-02-16 Patskovsky, Y.,Ho, M.,Toro, R.,Rutter, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Geranylgeranyl Pyrophosphate Synthase from Corynebacterium Glutamicum To be Published 0 0 0 0 3LOM 23493556 CRYSTAL STRUCTURE OF GERANYLTRANSFERASE FROM Legionella pneumophila 2010-02-04 2010-02-16 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3JS2 20121196 Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid 2009-09-09 2010-02-23 Ravindranathan, K.P.,Mandiyan, V.,Ekkati, A.R.,Bae, J.H.,Schlessinger, J.,Jorgensen, W.L. Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening J.Med.Chem. 2010 53 1662 1672 3KQB 20100660 Factor xa in complex with the inhibitor n-(3-fluoro-2'- (methylsulfonyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-1h- pyrazole-5-carboxamide 2009-11-17 2010-02-23 Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett. 2010 20 1373 1377 3KQC 20100660 Factor xa in complex with the inhibitor 6-(2'- (methylsulfonyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h- 1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-5,6- dihydro-1h-pyrazolo[3,4-c]pyridin-7(4h)-one 2009-11-17 2010-02-23 Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett. 2010 20 1373 1377 3KQD 20100660 Factor xa in complex with the inhibitor 1-(3-(5-oxo-4,5- dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'-(pyrrolidin-1- ylmethyl)biphenyl-4-yl)-3-(trifluoromethyl)-5,6-dihydro- 1h-pyrazolo[3,4-c]pyridin-7(4h)-one 2009-11-17 2010-02-23 Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett. 2010 20 1373 1377 3KQE 20100660 Factor xa in complex with the inhibitor 3-methyl-1-(3-(5- oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-6-(2'- (pyrrolidin-1-ylmethyl)biphenyl-4-yl)-5,6-dihydro-1h- pyrazolo[3,4-c]pyridin-7(4h)-one 2009-11-17 2010-02-23 Quan, M.L.,Pinto, D.J.,Rossi, K.A.,Sheriff, S.,Alexander, R.S.,Amparo, E.,Kish, K.,Knabb, R.M.,Luettgen, J.M.,Morin, P.,Smallwood, A.,Woerner, F.J.,Wexler, R.R. Phenyltriazolinones as potent factor Xa inhibitors. Bioorg.Med.Chem.Lett. 2010 20 1373 1377 3L2O 20181953 Structure-Based Mechanism of Dimerization-Dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase 2009-12-15 2010-02-23 Li, Y.,Hao, B. Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. J.Biol.Chem. 2010 285 13896 13906 3LHL Crystal structure of a putative agmatinase from Clostridium difficile 2010-01-22 2010-02-23 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of a putative agmatinase from Clostridium difficile To be Published 0 0 0 0 3LM4 Crystal Structure of 2,3-Dihydroxy Biphenyl dioxygenase from Rhodococcus sp. (strain RHA1) 2010-01-29 2010-02-23 Syed Ibrahim, B.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal Structure of 2,3-Dihydroxy Biphenyl dioxygenase from Rhodococcus sp. (strain RHA1) To be Published 0 0 0 0 3LNX 20839809 Second PDZ domain from human PTP1E 2010-02-03 2010-02-23 Zhang, J.,Sapienza, P.J.,Ke, H.,Chang, A.,Hengel, S.R.,Wang, H.,Phillips, G.N.,Lee, A.L. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry 2010 49 9280 9291 3LNX 20839809 Second PDZ domain from human PTP1E 2010-02-03 2010-02-23 Zhang, J.,Sapienza, P.J.,Ke, H.,Chang, A.,Hengel, S.R.,Wang, H.,Phillips, G.N.,Lee, A.L. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry 2010 49 9280 9291 3LOP Crystal structure of substrate-binding periplasmic protein (Pbp) from Ralstonia solanacearum 2010-02-04 2010-02-23 Palani, K.,Burley, S.K.,Swaminathan, S. Crystal structure of substrate-binding periplasmic protein (Pbp) from Ralstonia solanacearum To be Published 0 0 0 0 3LPM Crystal structure of putative methyltransferase small domain protein from Listeria monocytogenes 2010-02-05 2010-02-23 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative methyltransferase small domain protein from Listeria monocytogenes To be Published 0 0 0 0 3LQ7 Crystal structure of glutathione s-transferase from agrobacterium tumefaciens str. c58 2010-02-08 2010-02-23 Patskovsky, Y.,Toro, R.,Gilmore, M.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Glutathione S-Transferase from Agrobacterium Tumefaciens To be Published 0 0 0 0 3F6P 19574649 Crystal Structure of unphosphorelated receiver domain of YycF 2008-11-06 2010-03-02 Zhao, H.,Heroux, A.,Sequeira, R.D.,Tang, L. Preliminary crystallographic studies of the regulatory domain of response regulator YycF from an essential two-component signal transduction system. Acta Crystallogr.,Sect.F 2009 65 719 722 3K5S 20190755 Crystal structure of chicken T-cadherin EC1 EC2 2009-10-07 2010-03-02 Ciatto, C.,Bahna, F.,Zampieri, N.,Vansteenhouse, H.C.,Katsamba, P.S.,Ahlsen, G.,Harrison, O.J.,Brasch, J.,Jin, X.,Posy, S.,Vendome, J.,Ranscht, B.,Jessell, T.M.,Honig, B.,Shapiro, L. T-cadherin structures reveal a novel adhesive binding mechanism Nat.Struct.Mol.Biol. 2010 17 339 347 3K6D 20190755 Crystal structure of Xenopus laevis T-cadherin EC1 2009-10-08 2010-03-02 Ciatto, C.,Bahna, F.,Zampieri, N.,Vansteenhouse, H.C.,Katsamba, P.S.,Ahlsen, G.,Harrison, O.J.,Brasch, J.,Jin, X.,Posy, S.,Vendome, J.,Ranscht, B.,Jessell, T.M.,Honig, B.,Shapiro, L. T-cadherin structures reveal a novel adhesive binding mechanism Nat.Struct.Mol.Biol. 2010 17 339 347 3K6I 20190755 Crystal structure of chicken T-cadherin EC1 2009-10-08 2010-03-02 Ciatto, C.,Bahna, F.,Zampieri, N.,Vansteenhouse, H.C.,Katsamba, P.S.,Ahlsen, G.,Harrison, O.J.,Brasch, J.,Jin, X.,Posy, S.,Vendome, J.,Ranscht, B.,Jessell, T.M.,Honig, B.,Shapiro, L. T-cadherin structures reveal a novel adhesive binding mechanism Nat.Struct.Mol.Biol. 2010 17 339 347 3K8O Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH 2009-10-14 2010-03-02 Ho, M.,Rinaldo-matthis, A.,Almo, S.C.,Schramm, V.L. Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-Immucillin H Proc.Natl.Acad.Sci.USA 2010 0 0 0 3K8Q Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H 2009-10-14 2010-03-02 Ho, M.,Almo, S.C.,Scharmm, V.L. Crystal structure of human nucleoside phosphorylase in complex with SerMe-ImmH Proc.Natl.Acad.Sci.USA 2010 0 0 0 3KXX 20133753 Structure of the mutant Fibroblast Growth Factor receptor 1 2009-12-04 2010-03-02 Bae, J.H.,Boggon, T.J.,Tome, F.,Mandiyan, V.,Lax, I.,Schlessinger, J. Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells. Proc.Natl.Acad.Sci.USA 2010 107 2866 2871 3LGX Structure of probable D-alanine-poly(phosphoribitol) ligase subunit-1 from Streptococcus pyogenes with ATP 2010-01-21 2010-03-02 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of probable D-alanine-poly(phosphoribitol) ligase subunit-1 from Streptococcus pyogenes with ATP To be published 0 0 0 0 3LHX Crystal structure of a Ketodeoxygluconokinase (kdgk) from Shigella flexneri 2010-01-23 2010-03-02 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Crystal structure of a Ketodeoxygluconokinase (kdgk) from Shigella flexneri To be Published 0 0 0 0 3LME Structure of probable translation initiation inhibitor from (RPA2473) from Rhodopseudomonas palustris 2010-01-29 2010-03-02 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of probable translation initiation inhibitor from (RPA2473) from Rhodopseudomonas palustris To be published 0 0 0 0 3LSN Crystal structure of putative geranyltranstransferase from PSEUDOMONAS fluorescens PF-5 complexed with magnesium 2010-02-12 2010-03-02 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative geranyltranstransferase from Pseudomonas fluorescens PF-5 complexed with magnesium To be Published 0 0 0 0 3LUF Structure of probable two-component system response regulator/GGDEF domain protein 2010-02-17 2010-03-02 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of probable two-component system response regulator/GGDEF domain protein To be published 0 0 0 0 3I55 19738021 Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit 2009-07-03 2010-03-09 Gurel, G.,Blaha, G.,Steitz, T.A.,Moore, P.B. Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob.Agents Chemother. 2009 53 5010 5014 3I56 19738021 Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit 2009-07-03 2010-03-09 Gurel, G.,Blaha, G.,Steitz, T.A.,Moore, P.B. Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob.Agents Chemother. 2009 53 5010 5014 3LK5 Crystal structure of putative Geranylgeranyl pyrophosphate synthase from Corynebacterium glutamicum 2010-01-27 2010-03-09 Malashkevich, V.N.,Toro, R.,Patskovsky, Y.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative Geranylgeranyl pyrophosphate synthase from Corynebacterium glutamicum Atcc 13032 To be Published 0 0 0 0 3LVS 23493556 Crystal structure of farnesyl diphosphate synthase from rhodobacter capsulatus sb1003 2010-02-22 2010-03-09 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3LXT Crystal structure of Glutathione S Transferase from Pseudomonas fluorescens 2010-02-25 2010-03-09 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of Glutathione S Transferase from Pseudomonas fluorescens To be Published 0 0 0 0 3LXZ Structure of probable Glutathione S-transferase(PP0183) from Pseudomonas putida 2010-02-25 2010-03-09 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of probable Glutathione S-transferase(PP0183) from Pseudomonas putida To be published 0 0 0 0 3KXW 21185305 The crystal structure of fatty acid AMP ligase from Legionella pneumophila 2009-12-04 2010-03-16 Zhang, Z.,Zhou, R.,Sauder, J.M.,Tonge, P.J.,Burley, S.K.,Swaminathan, S. Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila. J.Mol.Biol. 2011 406 313 324 3M0F Crystal structure of Glutathione S Transferase in complex with glutathione from Pseudomonas fluorescens 2010-03-03 2010-03-16 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal structure of Glutathione S Transferase in complex with glutathione from Pseudomonas fluorescens To be Published 0 0 0 0 3HEA 20112920 The L29P/L124I mutation of Pseudomonas fluorescens esterase 2009-05-08 2010-03-23 Yin de, L.T.,Bernhardt, P.,Morley, K.L.,Jiang, Y.,Cheeseman, J.D.,Purpero, V.,Schrag, J.D.,Kazlauskas, R.J. Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase. Biochemistry 2010 49 1931 1942 3HEA 20112920 The L29P/L124I mutation of Pseudomonas fluorescens esterase 2009-05-08 2010-03-23 Yin de, L.T.,Bernhardt, P.,Morley, K.L.,Jiang, Y.,Cheeseman, J.D.,Purpero, V.,Schrag, J.D.,Kazlauskas, R.J. Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase. Biochemistry 2010 49 1931 1942 3LNY 20839809 Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide 2010-02-03 2010-03-23 Zhang, J.,Sapienza, P.J.,Ke, H.,Chang, A.,Hengel, S.R.,Wang, H.,Phillips, G.N.,Lee, A.L. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry 2010 49 9280 9291 3LNY 20839809 Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide 2010-02-03 2010-03-23 Zhang, J.,Sapienza, P.J.,Ke, H.,Chang, A.,Hengel, S.R.,Wang, H.,Phillips, G.N.,Lee, A.L. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry 2010 49 9280 9291 3LUA Crystal structure of a Signal receiver domain of Two component Signal Transduction (Histidine Kinase) from Clostridium thermocellum 2010-02-17 2010-03-23 Satyanarayana, L.,Burley, S.K.,Swaminathan, S. Crystal structure of a Signal receiver domain of Two component Signal Transduction (Histidine Kinase) from Clostridium thermocellum To be Published 0 0 0 0 3LYB Structure of putative endoribonuclease(KP1_3112) from Klebsiella pneumoniae 2010-02-26 2010-03-23 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of putative endoribonuclease(KP1_3112) from Klebsiella pneumoniae To be published 0 0 0 0 3LYK Structure of stringent starvation protein A homolog from Haemophilus influenzae 2010-02-27 2010-03-23 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of stringent starvation protein A homolog from Haemophilus influenzae To be published 0 0 0 0 3LYP Structure of stringent starvation protein A homolog from Pseudomonas fluorescens 2010-02-28 2010-03-23 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of stringent starvation protein A homolog from Pseudomonas fluorescens To be published 0 0 0 0 3LLW Crystal structure of geranyltransferase from helicobacter pylori 26695 2010-01-29 2010-03-31 Patskovsky, Y.,Toro, R.,Rutter, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Geranyltransferase from Helicobacter Pylori To be Published 0 0 0 0 3LQ1 Crystal structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylic acid synthase/2-oxoglutarate decarboxylase FROM Listeria monocytogenes str. 4b F2365 2010-02-08 2010-03-31 Patskovsky, Y.,Toro, R.,Freeman, J.,Hu, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Sephchc Synthase from Listeria Monocytogenes To be Published 0 0 0 0 3LTE CRYSTAL STRUCTURE OF RESPONSE REGULATOR (SIGNAL RECEIVER DOMAIN) FROM Bermanella marisrubri 2010-02-15 2010-03-31 Patskovsky, Y.,Toro, R.,Gilmore, M.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF RESPONSE REGULATOR SIGNAL RECEIVER DOMAIN FROM Bermanella marisrubri RED65 To be Published 0 0 0 0 3M0G CRYSTAL STRUCTURE OF putative farnesyl diphosphate synthase from Rhodobacter capsulatus 2010-03-03 2010-03-31 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF putative farnesyl diphosphate synthase from Rhodobacter capsulatus To be Published 0 0 0 0 3LNV 21185305 The crystal structure of fatty acyl-adenylate ligase from L. pneumophila in complex with acyl adenylate and pyrophosphate 2010-02-03 2010-04-07 Zhang, Z.,Zhou, R.,Sauder, J.M.,Tonge, P.J.,Burley, S.K.,Swaminathan, S. Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila. J.Mol.Biol. 2011 406 313 324 3M2T The crystal structure of dehydrogenase from Chromobacterium violaceum 2010-03-08 2010-04-07 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of dehydrogenase from Chromobacterium violaceum To be Published 0 0 0 0 3M8N Crystal structure of a possible gutathione S-tranferase from Rhodopseudomonas palustris 2010-03-18 2010-04-07 Damodharan, L.,Burley, S.K.,Swaminathan, S. Crystal structure of a possible gutathione S-tranferase from Rhodopseudomonas palustris To be Published 0 0 0 0 3M9L Crystal structure of probable had family hydrolase from pseudomonas fluorescens pf-5 2010-03-22 2010-04-07 Patskovsky, Y.,Toro, R.,Freeman, J.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Had Family Hydrolase from Pseudomonas Fluorescens Pf-5 To be Published 0 0 0 0 3M9U Crystal structure of geranylgeranyl pyrophosphate synthase from lactobacillus brevis atcc 367 2010-03-22 2010-04-07 Patskovsky, Y.,Toro, R.,Rutter, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Geranylgeranyl Pyrophosphate Synthase from Lactobacillus Brevis Atcc 367 To be Published 0 0 0 0 3MAE CRYSTAL STRUCTURE OF PROBABLE DIHYDROLIPOAMIDE ACETYLTRANSFERASE FROM LISTERIA MONOCYTOGENES 4b F2365 2010-03-23 2010-04-07 Patskovsky, Y.,Toro, R.,Gilmore, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF A CATALYTIC DOMAIN OF DIHYDROLIPOAMIDE ACETYLTRANSFERASE FROM LISTERIA MONOCYTOGENES 4b F2365 To be Published 0 0 0 0 3LNM 20360102 F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel 2010-02-02 2010-04-14 Tao, X.,Lee, A.,Limapichat, W.,Dougherty, D.A.,MacKinnon, R. A gating charge transfer center in voltage sensors. Science 2010 328 67 73 3ME7 Crystal structure of putative electron transport protein aq_2194 from Aquifex aeolicus VF5 2010-03-31 2010-04-14 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative electron transport protein aq_2194 from Aquifex aeolicus VF5 To be Published 0 0 0 0 3ME8 Crystal structure of putative electron transfer protein aq_2194 from Aquifex aeolicus VF5 2010-03-31 2010-04-14 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative electron transfer protein aq_2194 from Aquifex aeolicus VF5 To be Published 0 0 0 0 3MF4 Crystal structure of putative two-component system response regulator/ggdef domain protein 2010-04-01 2010-04-14 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative two-component system response regulator/ggdef domain protein To be Published 0 0 0 0 3KGD 20399182 Crystal structure of E. coli RNA 3' cyclase 2009-10-28 2010-04-21 Tanaka, N.,Smith, P.,Shuman, S. Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer. Structure 2010 18 449 457 3ME5 Crystal structure of putative dna cytosine methylase from shigella flexneri 2a str. 2457T 2010-03-31 2010-04-21 Ramagopal, U.A.,Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative dna cytosine methylase from shigella flexneri 2a str. 2457T To be Published 0 0 0 0 3MGG Crystal Structure of Methyl Transferase from Methanosarcina mazei 2010-04-06 2010-04-21 Syed Ibrahim, B.,Burley, S.K.,Swaminathan, S. Crystal Structure of Methyl Transferase from Methanosarcina mazei To be Published 0 0 0 0 3MGK CRYSTAL STRUCTURE OF PROBABLE PROTEASE/AMIDASE FROM Clostridium acetobutylicum ATCC 824 2010-04-06 2010-04-21 Patskovsky, Y.,Toro, R.,Freeman, J.,Iizuka, M.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF PROBABLE PROTEASE/AMIDASE FROM Clostridium acetobutylicum To be Published 0 0 0 0 3H3J Crystal structure of lactate dehydrogenase mutant (A85R) from staphylococcus aureus complexed with NAD and pyruvate 2009-04-16 2010-04-28 Ho, M.-C.,Almo, S.C.,Schramm, V.L. Crystal structure of lactate dehydrogenase mutant (A85R) from staphylococcus aureus complexed with NAD and pyruvate To be Published 0 0 0 0 3HGU 20516619 Structure of Phenazine Antibiotic Biosynthesis Protein 2009-05-14 2010-04-28 Bera, A.K.,Atanasova, V.,Gamage, S.,Robinson, H.,Parsons, J.F. Structure of the D-alanylgriseoluteic acid biosynthetic protein EhpF, an atypical member of the ANL superfamily of adenylating enzymes. Acta Crystallogr. D Biol. Crys 2010 66 664 672 3HGV 20516619 Structure of Phenazine Antibiotic Biosynthesis Protein 2009-05-14 2010-04-28 Bera, A.K.,Atanasova, V.,Gamage, S.,Robinson, H.,Parsons, J.F. Structure of the D-alanylgriseoluteic acid biosynthetic protein EhpF, an atypical member of the ANL superfamily of adenylating enzymes. Acta Crystallogr. D Biol. Crys 2010 66 664 672 3M06 20385093 Crystal Structure of TRAF2 2010-03-02 2010-04-28 Zheng, C.,Kabaleeswaran, V.,Wang, Y.,Cheng, G.,Wu, H. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol.Cell 2010 38 101 113 3M0D 20385093 Crystal structure of the TRAF1:TRAF2:cIAP2 complex 2010-03-02 2010-04-28 Zheng, C.,Kabaleeswaran, V.,Wang, Y.,Cheng, G.,Wu, H. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol.Cell 2010 38 101 113 3MHF 20427286 Tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes 2010-04-07 2010-04-28 LowKam, C.,Liotard, B.,Sygusch, J. Structure of a class I tagatose-1,6-bisphosphate aldolase: investigation into an apparent loss of stereospecificity. J.Biol.Chem. 2010 285 21143 21152 3MHG 20427286 Dihydroxyacetone phosphate carbanion intermediate in tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes 2010-04-07 2010-04-28 LowKam, C.,Liotard, B.,Sygusch, J. Structure of a class I tagatose-1,6-bisphosphate aldolase: investigation into an apparent loss of stereospecificity. J.Biol.Chem. 2010 285 21143 21152 3MMZ 23848398 CRYSTAL STRUCTURE OF putative HAD family hydrolase from Streptomyces avermitilis MA-4680 2010-04-20 2010-04-28 Daughtry, K.D.,Huang, H.,Malashkevich, V.,Patskovsky, Y.,Liu, W.,Ramagopal, U.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Dunaway-Mariano, D.,Allen, K.N. Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis. Biochemistry 2013 52 5372 5386 3MN1 23848398 Crystal structure of probable yrbi family phosphatase from pseudomonas syringae pv.phaseolica 1448a 2010-04-20 2010-04-28 Daughtry, K.D.,Huang, H.,Malashkevich, V.,Patskovsky, Y.,Liu, W.,Ramagopal, U.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Dunaway-Mariano, D.,Allen, K.N. Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis. Biochemistry 2013 52 5372 5386 3L6F 20417641 Structure of MHC class II molecule HLA-DR1 complexed with phosphopeptide MART-1 2009-12-23 2010-05-12 Li, Y.,Depontieu, F.R.,Sidney, J.,Salay, T.M.,Engelhard, V.H.,Hunt, D.F.,Sette, A.,Topalian, S.L.,Mariuzza, R.A. Structural Basis for the Presentation of Tumor-Associated MHC Class II-Restricted Phosphopeptides to CD4(+) T Cells. J.Mol.Biol. 2010 399 596 603 3LZI 20411947 RB69 DNA Polymerase (Y567A) ternary complex with dATP Opposite 7,8-dihydro-8-oxoguanine 2010-03-01 2010-05-12 Beckman, J.,Wang, M.,Blaha, G.,Wang, J.,Konigsberg, W.H. Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine . Biochemistry 2010 49 4116 4125 3M0W Structure of S100A4 with PCP 2010-03-03 2010-05-12 Ramagopal, U.A.,Dulyaninova, N.G.,Almo, S.C.,Bresnick, A.R. Structure of S100A4 with PCP To be published 0 0 0 0 3M22 20416505 Crystal structure of TagRFP fluorescent protein 2010-03-06 2010-05-12 Subach, O.M.,Malashkevich, V.N.,Zencheck, W.D.,Morozova, K.S.,Piatkevich, K.D.,Almo, S.C.,Verkhusha, V.V. Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins. Chem.Biol. 2010 17 333 341 3MDK Structure of stringent starvation protein A (sspA) from Pseudomonas putida 2010-03-30 2010-05-12 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of stringent starvation protein A (sspA) from Pseudomonas putida To be published 0 0 0 0 3MDN Structure of glutamine aminotransferase class-II domain protein (SPO2029) from silicibacter pomeroyi 2010-03-30 2010-05-12 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of glutamine aminotransferase class-II domain protein (SPO2029) from silicibacter pomeroyi To be published 0 0 0 0 3MPO The crystal structure of a hydrolase from Lactobacillus brevis 2010-04-27 2010-05-12 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of a hydrolase from Lactobacillus brevis To be Published 0 0 0 0 3MQT Crystal structure of a mandelate racemase/muconate lactonizing enzyme from Shewanella pealeana 2010-04-28 2010-05-12 Agarwal, R.,Burley, S.K.,Swaminathan, S. Crystal STRUCTURE OF A MANDELATE RACEMASE/MUCONATE LACTONIZING ENZYME FROM SHEWANELLA PEALEANA To be Published 0 0 0 0 3MSR The crystal structure of an amidohydrolase from Mycoplasma synoviae 2010-04-29 2010-05-12 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of an amidohydrolase from Mycoplasma synoviae To be Published 0 0 0 0 3LZJ 20411947 RB69 DNA Polymerase (Y567A) ternary complex with dCTP Opposite 7,8-Dihydro-8-oxoguanine 2010-03-01 2010-05-19 Beckman, J.,Wang, M.,Blaha, G.,Wang, J.,Konigsberg, W.H. Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine . Biochemistry 2010 49 4116 4125 3MTT 21139197 Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target HR5531C 2010-04-30 2010-05-19 Schauder, C.,Ma, L.C.,Krug, R.M.,Montelione, G.T.,Guan, R. Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85beta subunit reveals conformational plasticity in the interhelical turn region Acta Crystallogr.,Sect.F 2010 66 1567 1571 3MWC Crystal structure of probable o-succinylbenzoic acid synthetase from kosmotoga olearia 2010-05-05 2010-05-19 Patskovsky, Y.,Toro, R.,Dickey, M.,Sauder, J.M.,Gerlt, J.,Burley, S.K.,Almo, S.C. Crystal Structure of O-Succinylbenzoic Acid Synthetase from Kosmotoga Olearia To be Published 0 0 0 0 3K9A 20525690 Crystal Structure of HIV gp41 with MPER 2009-10-15 2010-05-26 Shi, W.,Bohon, J.,Han, D.P.,Habte, H.,Qin, Y.,Cho, M.W.,Chance, M.R. Structural characterization of HIV gp41 with the membrane-proximal external region J.Biol.Chem. 2010 285 24290 24298 3LW9 20516623 Structure of a Cytoplasmic Domain of Salmonella InvA 2010-02-23 2010-05-26 Lilic, M.,Quezada, C.M.,Stebbins, C.E. A conserved domain in type III secretion links the cytoplasmic domain of InvA to elements of the basal body. Acta Crystallogr.,Sect.D 2010 66 709 713 3M24 20416505 Crystal structure of TagBFP fluorescent protein 2010-03-06 2010-05-26 Subach, O.M.,Malashkevich, V.N.,Zencheck, W.D.,Morozova, K.S.,Piatkevich, K.D.,Almo, S.C.,Verkhusha, V.V. Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins. Chem.Biol. 2010 17 333 341 3MZN Crystal structure of probable glucarate dehydratase from chromohalobacter salexigens dsm 3043 2010-05-12 2010-05-26 Patskovsky, Y.,Toro, R.,Rutter, M.,Sauder, J.M.,Gerlt, J.A.,Burley, S.K.,Almo, S.C. Crystal Structure of Glucarate Dehydratase from Chromohalobacter Salexigens To be Published 0 0 0 0 3HJ3 24324854 Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant 2009-05-20 2010-06-02 Martucci, W.E.,Rodriguez, J.M.,Vargo, M.A.,Marr, M.,Hamilton, A.D.,Anderson, K.S. Exploring novel strategies for AIDS protozoal pathogens: alpha-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR. Medchemcomm 2013 4 1247 1256 3HLM 19826765 Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase/Kynurenine Aminotransferase IV 2009-05-27 2010-06-02 Han, Q.,Cai, T.,Tagle, D.A.,Li, J. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Cell.Mol.Life Sci. 2010 67 353 368 3MOP 20485341 The ternary Death Domain complex of MyD88, IRAK4, and IRAK2 2010-04-23 2010-06-02 Lin, S.C.,Lo, Y.C.,Wu, H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 2010 465 885 890 3MQP Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930 2010-04-28 2010-06-02 Guan, R.,Xiao, R.,Zhao, L.,Acton, T.B.,Gelinas, C.,Montelione, G.T. Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide To be Published 0 0 0 0 3N2C 20604542 Crystal structure of prolidase eah89906 complexed with n-methylphosphonate-l-proline 2010-05-17 2010-06-02 Xiang, D.F.,Patskovsky, Y.,Xu, C.,Fedorov, A.A.,Fedorov, E.V.,Sisco, A.A.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Raushel, F.M. Functional identification and structure determination of two novel prolidases from cog1228 in the amidohydrolase superfamily . Biochemistry 2010 49 6791 6803 3N3D Crystal structure of geranylgeranyl pyrophosphate synthase from lactobacillus brevis atcc 367 2010-05-19 2010-06-02 Patskovsky, Y.,Toro, R.,Rutter, M.,Chang, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Geranylgeranyl Pyrophosphate Synthase from Lactobacillus Brevis To be Published 0 0 0 0 3MGC 20361791 Teg12 Apo 2010-04-05 2010-06-09 Bick, M.J.,Banik, J.J.,Darst, S.A.,Brady, S.F. Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry 2010 49 4159 4168 3MT5 20508092 Crystal Structure of the Human BK Gating Apparatus 2010-04-30 2010-06-09 Yuan, P.,Leonetti, M.D.,Pico, A.R.,Hsiung, Y.,MacKinnon, R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science 2010 329 182 186 3MT5 20508092 Crystal Structure of the Human BK Gating Apparatus 2010-04-30 2010-06-09 Yuan, P.,Leonetti, M.D.,Pico, A.R.,Hsiung, Y.,MacKinnon, R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science 2010 329 182 186 3MT5 20508092 Crystal Structure of the Human BK Gating Apparatus 2010-04-30 2010-06-09 Yuan, P.,Leonetti, M.D.,Pico, A.R.,Hsiung, Y.,MacKinnon, R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science 2010 329 182 186 3MZV 23493556 Crystal structure of a decaprenyl diphosphate synthase from Rhodobacter capsulatus 2010-05-13 2010-06-09 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3N4E CRYSTAL STRUCTURE OF mandelate racemase/muconate lactonizing protein from Paracoccus denitrificans Pd1222 2010-05-21 2010-06-09 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF mandelate racemase/muconate lactonizing protein from Paracoccus denitrificans Pd1222 To be Published 0 0 0 0 3N4F CRYSTAL STRUCTURE OF Mandelate racemase/muconate lactonizing protein from Geobacillus sp. Y412MC10 2010-05-21 2010-06-09 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. CRYSTAL STRUCTURE OF Mandelate racemase/muconate lactonizing protein from Geobacillus sp. Y412MC10 To be Published 0 0 0 0 3IJJ 20534506 Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer) 2009-08-04 2010-06-16 Cho, Y.,Crichlow, G.V.,Vermeire, J.J.,Leng, L.,Du, X.,Hodsdon, M.E.,Bucala, R.,Cappello, M.,Gross, M.,Gaeta, F.,Johnson, K.,Lolis, E.J. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA 2010 107 11313 11318 3MI0 20461058 Crystal Structure of Mycobacterium Tuberculosis Proteasome at 2.2 A 2010-04-09 2010-06-23 Li, D.,Li, H.,Wang, T.,Pan, H.,Lin, G.,Li, H. Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome. Embo J. 2010 0 0 0 3MOG Crystal structure of 3-hydroxybutyryl-CoA dehydrogenase from Escherichia coli K12 substr. MG1655 2010-04-22 2010-06-23 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Gilmore, M.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of 3-Hydroxybutyryl-Coa Dehydrogenase from Escherichia Coli K12 To be Published 0 0 0 0 3N10 21094652 Product complex of adenylate cyclase class IV 2010-05-14 2010-06-23 Gallagher, D.T.,Kim, S.K.,Robinson, H.,Reddy, P.T. Active-Site Structure of Class IV Adenylyl Cyclase and Transphyletic Mechanism. J.Mol.Biol. 2011 405 787 803 3NFU Crystal structure of probable glucarate dehydratase from chromohalobacter salexigens dsm 3043 complexed with magnesium 2010-06-10 2010-06-23 Patskovsky, Y.,Toro, R.,Rutter, M.,Sauder, J.M.,Gerlt, J.A.,Burley, S.K.,Almo, S.C. Crystal Structure of Glucarate Dehydratase from Chromohalobacter Salexigens To be Published 0 0 0 0 3KXY 20536183 Crystal Structure of the ExsC-ExsE Complex 2009-12-04 2010-06-30 Vogelaar, N.J.,Jing, X.,Robinson, H.H.,Schubot, F.D. Analysis of the Crystal Structure of the ExsC.ExsE Complex Reveals Distinctive Binding Interactions of the Pseudomonas aeruginosa Type III Secretion Chaperone ExsC with ExsE and ExsD. Biochemistry 2010 49 5870 5879 3M18 20616002 Crystal structure of variable lymphocyte receptor VLRA.R2.1 in complex with hen egg lysozyme 2010-03-04 2010-06-30 Deng, L.,Velikovsky, C.A.,Xu, G.,Iyer, L.M.,Tasumi, S.,Kerzic, M.C.,Flajnik, M.F.,Aravind, L.,Pancer, Z.,Mariuzza, R.A. A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey. Proc.Natl.Acad.Sci.USA 2010 107 13408 13413 3MSY Crystal Structure of Mandelate racemase/muconate lactonizing enzyme from a Marine actinobacterium 2010-04-29 2010-06-30 Satyanarayana, L.,Burley, S.K.,Swaminathan, S. Crystal Structure of Mandelate racemase/muconate lactonizing enzyme from a Marine actinobacterium To be Published 0 0 0 0 3MVA 20550934 Crystal structure of human MTERF1 bound to the termination sequence 2010-05-03 2010-06-30 Yakubovskaya, E.,Mejia, E.,Byrnes, J.,Hambardjieva, E.,Garcia-Diaz, M. Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell(Cambridge,Mass.) 2010 141 982 993 3NIW Crystal structure of a haloacid dehalogenase-like hydrolase from Bacteroides thetaiotaomicron 2010-06-16 2010-06-30 Bonanno, J.B.,Ramagopal, U.,Toro, R.,Rutter, M.,Bain, K.T.,Wu, B.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of a haloacid dehalogenase-like hydrolase from Bacteroides thetaiotaomicron To be Published 0 0 0 0 3MY9 Crystal structure of a muconate cycloisomerase from Azorhizobium caulinodans 2010-05-10 2010-07-07 Quartararo, C.E.,Ramagopal, U.,Bonanno, J.B.,Rutter, M.,Bain, K.T.,Miller, S.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of a muconate cycloisomerase from Azorhizobium caulinodans To be Published 0 0 0 0 3N05 CRYSTAL STRUCTURE OF NH3-DEPENDENT NAD+ SYNTHETASE FROM STREPTOMYCES AVERMITILIS 2010-05-13 2010-07-07 Patskovsky, Y.,Toro, R.,Freeman, J.,Do, J.,Sauder, J.M.,Gerlt, J.A.,Burley, S.K.,Almo, S.C. Crystal Structure of Nh3-Dependent Nad+ Synthetase from Streptomyces Avermitilis To be Published 0 0 0 0 3NJ2 22289180 Crystal structure of cce_0566 from the cyanobacterium Cyanothece 51142, a protein associated with nitrogen fixation from the DUF269 family 2010-06-16 2010-07-07 Buchko, G.W.,Robinson, H. Crystal structure of cce_0566 from Cyanothece 51142, a protein associated with nitrogen fixation in the DUF269 family. Febs Lett. 2012 586 350 355 3NO1 Crystal Structure of Mandelate racemase/muconate lactonizing enzyme from a Marine actinobacterium in complex with magnesium 2010-06-24 2010-07-07 Satyanarayana, L.,Burley, S.K.,Swaminathan, S. Crystal Structure of Mandelate racemase/muconate lactonizing enzyme from a Marine actinobacterium in complex with magnesium To be Published 0 0 0 0 3N28 Crystal structure of probable phosphoserine phosphatase from vibrio cholerae, unliganded form 2010-05-17 2010-07-14 Patskovsky, Y.,Ramagopal, U.,Toro, R.,Rutter, M.,Miller, S.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal Structure of Phosphoserine Phosphatase from Vibrio Cholerae To be Published 0 0 0 0 3NPK The crystal structure of geranyltranstransferase from Campylobacter jejuni 2010-06-28 2010-07-14 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of geranyltranstransferase from Campylobacter jejuni To be Published 0 0 0 0 3GAB 20603082 C-terminal domain of Bacillus subtilis MutL crystal form I 2009-02-17 2010-07-21 Pillon, M.C.,Lorenowicz, J.J.,Uckelmann, M.,Klocko, A.D.,Mitchell, R.R.,Chung, Y.S.,Modrich, P.,Walker, G.C.,Simmons, L.A.,Friedhoff, P.,Guarne, A. Structure of the endonuclease domain of MutL: unlicensed to cut. Mol.Cell 2010 39 145 151 3GAB 20603082 C-terminal domain of Bacillus subtilis MutL crystal form I 2009-02-17 2010-07-21 Pillon, M.C.,Lorenowicz, J.J.,Uckelmann, M.,Klocko, A.D.,Mitchell, R.R.,Chung, Y.S.,Modrich, P.,Walker, G.C.,Simmons, L.A.,Friedhoff, P.,Guarne, A. Structure of the endonuclease domain of MutL: unlicensed to cut. Mol.Cell 2010 39 145 151 3MPU 20620149 Crystal structure of the C47A/A241C disulfide-linked E. coli Aspartate Transcarbamoylase holoenzyme 2010-04-27 2010-07-21 Mendes, K.R.,Kantrowitz, E.R. The Pathway of Product Release from the R State of Aspartate Transcarbamoylase. J.Mol.Biol. 2010 401 940 948 3N0G 20624401 Crystal Structure of Isoprene Synthase from Grey Poplar Leaves (Populus x canescens) in complex with three Mg2+ ions and dimethylallyl-S-thiolodiphosphate 2010-05-14 2010-07-21 Koksal, M.,Zimmer, I.,Schnitzler, J.P.,Christianson, D.W. Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission. J.Mol.Biol. 2010 402 363 373 3N1U Structure of putative HAD superfamily (subfamily III A) hydrolase from Legionella pneumophila 2010-05-17 2010-07-21 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of putative HAD superfamily (subfamily III A) hydrolase from Legionella pneumophila To be published 0 0 0 0 3N6H Crystal structure of Mandelate racemase/muconate lactonizing protein from Actinobacillus succinogenes 130Z complexed with magnesium/sulfate 2010-05-25 2010-07-21 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of Mandelate racemase/muconate lactonizing protein from Actinobacillus succinogenes 130Z complexed with magnesium/sulfate To be Published 0 0 0 0 3N6J Crystal structure of Mandelate racemase/muconate lactonizing protein from Actinobacillus succinogenes 130Z 2010-05-25 2010-07-21 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of Mandelate racemase/muconate lactonizing protein from Actinobacillus succinogenes 130Z To be Published 0 0 0 0 3N53 Crystal structure of a response regulator receiver modulated diguanylate cyclase from Pelobacter carbinolicus 2010-05-24 2010-07-28 Palani, K.,Zhang, Z.,Burley, S.K.,Swaminathan, S. Crystal structure of a response regulator receiver modulated diguanylate cyclase from Pelobacter carbinolicus To be Published 0 0 0 0 3NAS The crystal structure of beta-phosphoglucomutase from Bacillus subtilis 2010-06-02 2010-07-28 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of beta-phosphoglucomutase from Bacillus subtilis To be Published 0 0 0 0 3NQB Crystal Structure of Adenine Deaminase from Agrobacterium tumefaciens (str. C 58) 2010-06-29 2010-07-28 Bagaria, A.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal Structure of Adenine Deaminase from Agrobacterium tumefaciens (str. 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Crystal Structure of the GerBC Component of a Bacillus subtilis Spore Germinant Receptor. J.Mol.Biol. 2010 402 8 16 3NF2 23493556 Crystal structure of polyprenyl synthetase from Streptomyces coelicolor A3(2) 2010-06-09 2010-08-04 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3LZS 20660190 Crystal Structure of HIV-1 CRF01_AE Protease in Complex with Darunavir 2010-03-01 2010-08-11 Bandaranayake, R.M.,Kolli, M.,King, N.M.,Nalivaika, E.A.,Heroux, A.,Kakizawa, J.,Sugiura, W.,Schiffer, C.A. The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways. J.Virol. 2010 84 9995 10003 3N1I 20551348 Crystal Structure of a StWhy2-ERE32 complex 2010-05-15 2010-08-11 Cappadocia, L.,Marechal, A.,Parent, J.S.,Lepage, E.,Sygusch, J.,Brisson, N. Crystal Structures of DNA-Whirly Complexes and Their Role in Arabidopsis Organelle Genome Repair. Plant Cell 2010 22 1849 1867 3NOX 20684603 Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone 2010-06-25 2010-08-11 Meng, W.,Brigance, R.P.,Chao, H.J.,Fura, A.,Harrity, T.,Marcinkeviciene, J.,O'Connor, S.P.,Tamura, J.K.,Xie, D.,Zhang, Y.,Klei, H.E.,Kish, K.,Weigelt, C.A.,Turdi, H.,Wang, A.,Zahler, R.,Kirby, M.S.,Hamann, L.G. Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors. J.Med.Chem. 2010 53 5620 5628 3NCY 19578361 X-ray crystal structure of an arginine agmatine antiporter (AdiC) in complex with a Fab fragment 2010-06-06 2010-08-18 Fang, Y.,Jayaram, H.,Shane, T.,Komalkova-Partensky, L.,Wu, F.,Williams, C.,Xiong, Y.,Miller, C. Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Nature 2009 460 1040 1043 3NT3 20681709 CRYSTAL STRUCTURE OF LSSmKate2 red fluorescent proteins with large Stokes shift 2010-07-02 2010-08-18 Piatkevich, K.D.,Malashkevich, V.N.,Almo, S.C.,Verkhusha, V.V. Engineering ESPT Pathways Based on Structural Analysis of LSSmKate Red Fluorescent Proteins with Large Stokes Shift. J.Am.Chem.Soc. 2010 132 10762 10770 3NT9 20681709 CRYSTAL STRUCTURE OF LSSmKate1 red fluorescent proteins with large Stokes shift 2010-07-03 2010-08-18 Piatkevich, K.D.,Malashkevich, V.N.,Almo, S.C.,Verkhusha, V.V. Engineering ESPT Pathways Based on Structural Analysis of LSSmKate Red Fluorescent Proteins with Large Stokes Shift. 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CRYSTAL STRUCTURE OF putative dioxygenase from Bacillus subtilis subsp. subtilis str. 168 To be Published 0 0 0 0 3OAN Crystal structure of the Ran Binding Domain From The Nuclear Complex Component Nup2 From Ashbya Gossypii 2010-08-05 2010-08-18 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of the Ran Binding Domain From The Nuclear Complex Component Nup2 From Ashbya Gossypii To be Published 0 0 0 0 3OCQ crystal structure of tRNA-specific Adenosine deaminase from Salmonella enterica 2010-08-10 2010-08-18 Kim, J.,Ramagopal, U.A.,Burley, S.K.,Almo, S.C. Crystal structure of tRNA-specific Adenosine deaminase from Salmonella enterica To be Published 0 0 0 0 3MXH 20690679 Native structure of a c-di-GMP riboswitch from V. cholerae 2010-05-07 2010-08-25 Smith, K.D.,Lipchock, S.V.,Livingston, A.L.,Shanahan, C.A.,Strobel, S.A. Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch . 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Crystal structure of PNP with an inhibitor DADME_immH from Vibrio cholerae To be Published 0 0 0 0 3OGG 20858456 Crystal structure of the receptor binding domain of botulinum neurotoxin D 2010-08-16 2010-09-01 Zhang, Y.,Buchko, G.W.,Qin, L.,Robinson, H.,Varnum, S.M. Structural analysis of the receptor binding domain of botulinum neurotoxin serotype D. Biochem.Biophys.Res.Commun. 2010 401 498 503 3OHP Crystal structure of HGPRT from Vibrio cholerae 2010-08-17 2010-09-01 Kim, J.,Ramagopal, U.A.,Almo, S.C.,Burley, S.K. Crystal structure of HGPRT from Vibrio cholerae To be Published 0 0 0 0 3M45 20739279 Crystal structure of Ig1 domain of mouse SynCAM 2 2010-03-10 2010-09-08 Fogel, A.I.,Li, Y.,Giza, J.,Wang, Q.,Lam, T.T.,Modis, Y.,Biederer, T. N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion. J.Biol.Chem. 2010 285 34864 34874 3JVX Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120A) 2009-09-17 2010-09-15 Beierlein, J.M.,Karri, N.G.,Anderson, A.C. Mutational Studies into Trimethoprim Resistance in Bacillus anthracis Dihydrofolate Reductase To be Published 0 0 0 0 3JW3 Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim 2009-09-17 2010-09-15 Beierlein, J.M.,Karri, N.G.,Anderson, A.C. Mutational Studies into Trimethoprim Resistance in Bacillus anthracis Dihydrofolate Reductase To be Published 0 0 0 0 3JW5 Crystal structure of Bacillus anthracis (Y102F) dihydrofolate reductase complexed with NADPH and Trimethoprim 2009-09-17 2010-09-15 Beierlein, J.M.,Karri, N.G.,Anderson, A.C. 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J.Virol. 2011 85 818 827 3O6F 21297580 Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4 2010-07-29 2011-03-02 Yin, Y.,Li, Y.,Kerzic, M.C.,Martin, R.,Mariuzza, R.A. Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection. Embo J. 2011 30 1137 1148 3QQV 23493556 Crystal structure of geranylgeranyl pyrophosphate synthase from corynebacterium glutamicum complexed with isoprenyl diphosphate and magnesium 2011-02-16 2011-03-02 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3MBZ 20822105 OXA-24 beta-lactamase complex soaked with 10mM SA4-17 inhibitor for 15min 2010-03-26 2011-03-16 Bou, G.,Santillana, E.,Sheri, A.,Beceiro, A.,Sampson, J.M.,Kalp, M.,Bethel, C.R.,Distler, A.M.,Drawz, S.M.,Pagadala, S.R.,van den Akker, F.,Bonomo, R.A.,Romero, A.,Buynak, J.D. Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase J.Am.Chem.Soc. 2010 132 13320 13331 3PV6 Crystal structure of NKp30 bound to its ligand B7-H6 2010-12-06 2011-03-16 Li, Y.,Wang, Q.,Mariuzza, R.A. Structure of the activating natural killer cell receptor NKp30 bound to its ligand B7-H6 reveals basis for tumor cell recognition in humans to be published 0 0 0 0 3PV7 Crystal structure of NKp30 ligand B7-H6 2010-12-06 2011-03-16 Li, Y.,Wang, Q.,Mariuzza, R.A. Structure of the activating natural killer cell receptor NKp30 bound to its ligand B7-H6 reveals basis for tumor cell recognition in humans to be published 0 0 0 0 3M3T SARS-CoV main protease monomeric Arg298Ala mutant with N-terminal additional residues (Gly-Ser) 2010-03-10 2011-03-23 Shi, J.H.,Song, J.X. SARS-CoV main protease with N-terminal extension regulated by mutation on C-terminal domain To be Published 0 0 0 0 3M3V SARS-CoV main protease triple mutant STI/A with two N-terminal additional residue (Gly-Ser) 2010-03-10 2011-03-23 Shi, J.H.,Song, J.X. SARS-CoV main protease with N-terminal extension regulated by mutations on the C-terminal domain To be Published 0 0 0 0 3QYB 21454505 X-ray Crystal Structure of Human TBC1D4 (AS160) RabGAP domain 2011-03-03 2011-03-23 Park, S.Y.,Jin, W.,Woo, J.R.,Shoelson, S.E. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. J.Biol.Chem. 2011 286 18130 18138 3QYE 21454505 Crystal Structure of Human TBC1D1 RabGAP domain 2011-03-03 2011-03-23 Park, S.Y.,Jin, W.,Woo, J.R.,Shoelson, S.E. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. J.Biol.Chem. 2011 286 18130 18138 3MDJ 21478864 ER Aminopeptidase, ERAP1, Bound to the Zinc Aminopeptidase Inhibitor, Bestatin 2010-03-30 2011-03-30 Nguyen, T.T.,Chang, S.C.,Evnouchidou, I.,York, I.A.,Zikos, C.,Rock, K.L.,Goldberg, A.L.,Stratikos, E.,Stern, L.J. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat.Struct.Mol.Biol. 2011 18 604 613 3PSI 21419780 Crystal Structure of the Spt6 core domain from Saccharomyces cerevisiae, Form Spt6(239-1451) 2010-12-01 2011-03-30 Close, D.,Johnson, S.J.,Sdano, M.A.,McDonald, S.M.,Robinson, H.,Formosa, T.,Hill, C.P. Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol. 2011 408 697 713 3QNM Haloalkane Dehalogenase Family Member from Bacteroides thetaiotaomicron of Unknown Function 2011-02-08 2011-03-30 Matthew, M.W.,Ramagopal, U.A.,Toro, R.,Dickey, M.,Sauder, J.M.,Poulter, C.D.,Burley, S.K.,Gerlt, J.A.,Almo, S.C. Haloalkane Dehalogenase Family Member from Bacteroides thetaiotaomicron of Unknown Function To be Published 0 0 0 0 3QP5 21504831 Crystal structure of CviR bound to antagonist chlorolactone (CL) 2011-02-11 2011-03-30 Chen, G.,Swem, L.R.,Swem, D.L.,Stauff, D.L.,O'Loughlin, C.T.,Jeffrey, P.D.,Bassler, B.L.,Hughson, F.M. A strategy for antagonizing quorum sensing. Mol.Cell 2011 42 199 209 3MB8 24585883 Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-H 2010-03-25 2011-04-06 Donaldson, T.M.,Cassera, M.B.,Ho, M.C.,Zhan, C.,Merino, E.F.,Evans, G.B.,Tyler, P.C.,Almo, S.C.,Schramm, V.L.,Kim, K. Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase. Eukaryot Cell 2014 13 572 579 3QZ7 21421759 T-3 ternary complex of Dpo4 2011-03-04 2011-04-06 Wu, Y.,Wilson, R.C.,Pata, J.D. The y-family DNA polymerase dpo4 uses a template slippage mechanism to create single-base deletions. J.Bacteriol. 2011 193 2630 2636 3QZ8 21421759 TT-4 ternary complex of Dpo4 2011-03-04 2011-04-06 Wu, Y.,Wilson, R.C.,Pata, J.D. The y-family DNA polymerase dpo4 uses a template slippage mechanism to create single-base deletions. J.Bacteriol. 2011 193 2630 2636 3R2G Crystal structure of Inosine 5' monophosphate dehydrogenase from Legionella pneumophila 2011-03-14 2011-04-06 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of Inosine 5' monophosphate dehydrogenase from Legionella pneumophila To be Published 0 0 0 0 3R31 Crystal structure of betaine aldehyde dehydrogenase from Agrobacterium tumefaciens 2011-03-15 2011-04-06 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of betaine aldehyde dehydrogenase from Agrobacterium tumefaciens To be Published 0 0 0 0 3R4Q Crystal structure of Lactoylglutathione lyase from Agrobacterium tumefaciens 2011-03-17 2011-04-06 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of Lactoylglutathione lyase from Agrobacterium tumefaciens To be Published 0 0 0 0 3R64 Crystal structure of a NAD-dependent benzaldehyde dehydrogenase from Corynebacterium glutamicum 2011-03-21 2011-04-06 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a NAD-dependent benzaldehyde dehydrogenase from Corynebacterium glutamicum To be Published 0 0 0 0 3R6A Crystal structure of an uncharacterized protein (hypothetical protein MM_3218) from Methanosarcina mazei. 2011-03-21 2011-04-06 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of an uncharacterized protein (hypothetical protein MM_3218) from Methanosarcina mazei. To be Published 0 0 0 0 3PVC 23617613 Crystal structure of apo MnmC from Yersinia Pestis 2010-12-06 2011-04-13 Kim, J.,Almo, S.C. Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. Bmc Struct.Biol. 2013 13 5 5 3QUQ 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, an open cap conformation 2011-02-24 2011-04-13 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QUT 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, asp13asn mutant, an open cap conformation 2011-02-24 2011-04-13 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QYP 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, glu47asn mutant complexed with calcium and phosphate 2011-03-03 2011-04-13 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3RCM crystal structure of EFI target 500140:TatD family hydrolase from Pseudomonas putida 2011-03-31 2011-04-20 Kim, J.,Toro, R.,Hillerich, B.,Seidel, R.D.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) crystal structure of EFI target 500140:TatD family hydrolase from Pseudomonas putida TO BE PUBLISHED 0 0 0 0 3QFQ 21501625 Asymmetric Assembly of Merkel Cell Polyomavirus Large T-antigen Origin Binding Domains at the Viral Origin 2011-01-22 2011-04-27 Harrison, C.J.,Meinke, G.,Kwun, H.J.,Rogalin, H.,Phelan, P.J.,Bullock, P.A.,Chang, Y.,Moore, P.S.,Bohm, A. Asymmetric assembly of merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J.Mol.Biol. 2011 409 529 542 3QI3 21483814 Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691 2011-01-26 2011-04-27 Hou, J.,Xu, J.,Liu, M.,Zhao, R.,Luo, H.B.,Ke, H. Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine. Plos One 2011 6 0 0 3QI4 21483814 Crystal structure of PDE9A(Q453E) in complex with IBMX 2011-01-26 2011-04-27 Hou, J.,Xu, J.,Liu, M.,Zhao, R.,Luo, H.B.,Ke, H. Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine. Plos One 2011 6 0 0 3QLD Structure of Probable Mandelate Racemase (AaLAA1DRAFT_2112) from Alicyclobacillus Acidocaldarius 2011-02-02 2011-04-27 Ramagopal, U.A.,Toro, R.,Burley, S.K.,Almo, S.C. Structure of Probable Mandelate Racemase (AaLAA1DRAFT_2112) from Alicyclobacillus Acidocaldarius To be published 0 0 0 0 3QU2 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, a closed cap conformation 2011-02-23 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QU4 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, asp13ala mutant 2011-02-23 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QU5 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, asp11asn mutant 2011-02-23 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QU7 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, asp13asn mutant complexed with calcium and phosphate 2011-02-23 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QU9 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, asp13asn mutant complexed with magnesium and tartrate 2011-02-23 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QUB 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, glu47ala mutant complexed with sulfate 2011-02-23 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QUC 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, glu47asn mutant complexed with sulfate 2011-02-23 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QX7 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron complexed with phosphate, a closed cap conformation 2011-03-01 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3QXG 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron complexed with calcium, a closed cap conformation 2011-03-01 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3R0N 22927415 Crystal Structure of the Immunoglobulin variable domain of Nectin-2 2011-03-08 2011-04-27 Samanta, D.,Ramagopal, U.A.,Rubinstein, R.,Vigdorovich, V.,Nathenson, S.G.,Almo, S.C. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion. Proc.Natl.Acad.Sci.USA 2012 109 14836 14840 3R9K 21894910 Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, glu47asp mutant complexed with sulfate, a closed cap conformation 2011-03-25 2011-04-27 Huang, H.,Patskovsky, Y.,Toro, R.,Farelli, J.D.,Pandya, C.,Almo, S.C.,Allen, K.N.,Dunaway-Mariano, D. Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase. Biochemistry 2011 50 8937 8949 3RHG Crystal structure of amidohydrolase pmi1525 (target efi-500319) from proteus mirabilis hi4320 2011-04-11 2011-04-27 Patskovsky, Y.,Hillerich, B.,Seidel, R.D.,Zencheck, W.D.,Toro, R.,Imker, H.J.,Raushel, F.M.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Amidohydrolase Pmi1525 from Proteus Mirabilis Hi4320 To be Published 0 0 0 0 3RHK 21454604 Crystal structure of the catalytic domain of c-Met kinase in complex with ARQ 197 2011-04-11 2011-04-27 Eathiraj, S.,Palma, R.,Volckova, E.,Hirschi, M.,France, D.S.,Ashwell, M.A.,Chan, T.C. Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197. J.Biol.Chem. 2011 286 20666 20676 3RJL Crystal structure of 1-pyrroline-5-carboxylate dehydrogenase from Bacillus licheniformis (Target NYSGRC-000337) 2011-04-15 2011-04-27 Patskovsky, Y.,Toro, R.,Foti, R.,Seidel, R.D.,Almo, S.C. Crystal Structure of 1-Pyrroline-5-Carboxylate Dehydrogenase from Bacillus Licheniformis To be Published 0 0 0 0 3RHA The crystal structure of Oxidoreductase from Arthrobacter aurescens 2011-04-11 2011-05-04 Zhang, Z.,Almo, S.C.,Swaminathan, S. The crystal structure of Oxidoreductase from Arthrobacter aurescens To be Published 0 0 0 0 3RHX 21454610 Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069 2011-04-12 2011-05-04 Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J.Biol.Chem. 2011 286 20677 20687 3RI1 21454610 Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069 2011-04-12 2011-05-04 Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J.Biol.Chem. 2011 286 20677 20687 3NPM 20681545 Crystal Structure of the C47A/A241C disulfide-linked C6 Aspartate Transcarbamoylase enzyme 2010-06-28 2011-05-11 Mendes, K.R.,Kantrowitz, E.R. A cooperative Escherichia coli aspartate transcarbamoylase without regulatory subunits . Biochemistry 2010 49 7694 7703 3OEM 21522138 Crystal structure of GluN2D ligand-binding core in complex with N-methyl-D-aspartate 2010-08-12 2011-05-11 Vance, K.M.,Simorowski, N.,Traynelis, S.F.,Furukawa, H. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun 2011 2 294 294 3OEN 21522138 Crystal structure of GluN2D ligand-binding core in complex with L-glutamate 2010-08-12 2011-05-11 Vance, K.M.,Simorowski, N.,Traynelis, S.F.,Furukawa, H. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun 2011 2 294 294 3Q3Z 21518891 Structure of a c-di-GMP-II riboswitch from C. acetobutylicum bound to c-di-GMP 2010-12-22 2011-05-11 Smith, K.D.,Shanahan, C.A.,Moore, E.L.,Simon, A.C.,Strobel, S.A. Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches. Proc.Natl.Acad.Sci.USA 2011 108 7757 7762 3RAZ The crystal structure of thioredoxin-related protein from Neisseria meningitidis serogroup B 2011-03-28 2011-05-11 Zhang, Z.,Burley, S.K.,Swaminathan, S. The crystal structure of thioredoxin-related protein from Neisseria meningitidis serogroup B To be Published 0 0 0 0 3RIU 21552261 Crystal structure of Drosophila hexameric C3PO formed by truncated Translin and Trax 2011-04-14 2011-05-11 Tian, Y.,Simanshu, D.K.,Ascano, M.,Diaz-Avalos, R.,Park, A.Y.,Juranek, S.A.,Rice, W.J.,Yin, Q.,Robinson, C.V.,Tuschl, T.,Patel, D.J. Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex. Nat.Struct.Mol.Biol. 2011 18 658 664 3RMG 23493556 Crystal structure of geranylgeranyl pyrophosphate synthase from bacteroides thetaiotaomicron 2011-04-20 2011-05-11 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3RR1 Crystal structure of enolase PRK14017 (target EFI-500653) from Ralstonia pickettii 12J 2011-04-28 2011-05-11 Patskovsky, Y.,Hillerich, B.,Seidel, R.D.,Zencheck, W.D.,Toro, R.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of enolase PRK14017 from Ralstonia pickettii To be Published 0 0 0 0 3RRA Crystal structure of enolase PRK14017 (target EFI-500653) from Ralstonia pickettii 12J with magnesium bound 2011-04-29 2011-05-11 Patskovsky, Y.,Ramagopal, U.A.,Hillerich, B.,Seidel, R.D.,Zencheck, W.D.,Toro, R.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of enolase PRK14017 from Ralstonia pickettii To be Published 0 0 0 0 3RCY CRYSTAL STRUCTURE OF Mandelate racemase/muconate lactonizing enzyme-like protein from Roseovarius sp. TM1035 2011-03-31 2011-05-18 Malashkevich, V.N.,Toro, R.,Seidel, R.,Garrett, S.,Foti, R.,Almo, S.C. CRYSTAL STRUCTURE OF Mandelate racemase/muconate lactonizing enzyme-like protein from Roseovarius sp. TM1035 To be Published 0 0 0 0 3RHD Crystal structure of glyceraldehyde-3-phosphate dehydrogenase GapN from Methanocaldococcus jannaschii DSM 2661 complexed with NADP 2011-04-11 2011-05-18 Malashkevich, V.N.,Toro, R.,Seidel, R.,Garrett, S.,Foti, R.,Almo, S.C. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase GapN from Methanocaldococcus jannaschii DSM 2661 complexed with NADP To be Published 0 0 0 0 3RHH Crystal structure of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Bacillus halodurans C-125 complexed with NADP 2011-04-11 2011-05-18 Malashkevich, V.N.,Toro, R.,Seidel, R.,Garrett, S.,Foti, R.,Almo, S.C. Crystal structure of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Bacillus halodurans C-125 complexed with NADP To be Published 0 0 0 0 3RMT Crystal structure of putative 5-enolpyruvoylshikimate-3-phosphate synthase from Bacillus halodurans C-125 2011-04-21 2011-05-18 Malashkevich, V.N.,Toro, R.,Seidel, R.,Ramagopal, U.,Zencheck, W.,Almo, S.C. Crystal structure of putative 5-enolpyruvoylshikimate-3-phosphate synthase from Bacillus halodurans C-125 To be Published 0 0 0 0 3ROS Crystal structure of NAD-dependent aldehyde dehydrogenase from Lactobacillus acidophilus 2011-04-26 2011-05-18 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of NAD-dependent aldehyde dehydrogenase from Lactobacillus acidophilus To be Published 0 0 0 0 3ROT Crystal structure of ABC sugar transporter (periplasmic sugar binding protein) from Legionella pneumophila 2011-04-26 2011-05-18 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of ABC sugar transporter (periplasmic sugar binding protein) from Legionella pneumophila To be Published 0 0 0 0 3N4M 33205945 E. coli RNA polymerase alpha subunit C-terminal domain in complex with CAP and DNA 2010-05-21 2011-05-25 Lara-Gonzalez, S.,Dantas Machado, A.C.,Rao, S.,Napoli, A.A.,Birktoft, J.,Di Felice, R.,Rohs, R.,Lawson, C.L. The RNA Polymerase alpha Subunit Recognizes the DNA Shape of the Upstream Promoter Element. Biochemistry 2020 59 4523 4532 3RBG 23583034 Crystal structure analysis of Class-I MHC restricted T-cell associated molecule 2011-03-29 2011-05-25 Rubinstein, R.,Ramagopal, U.A.,Nathenson, S.G.,Almo, S.C.,Fiser, A. Functional classification of immune regulatory proteins. Structure 2013 21 766 776 3NYJ 21574595 Crystal Structure Analysis of APP E2 domain 2010-07-15 2011-06-01 Lee, S.,Xue, Y.,Hu, J.,Wang, Y.,Liu, X.,Demeler, B.,Ha, Y. The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. Biochemistry 2011 50 5453 5464 3PMR 21574595 Crystal Structure of E2 domain of Human Amyloid Precursor-Like Protein 1 2010-11-17 2011-06-01 Lee, S.,Xue, Y.,Hu, J.,Wang, Y.,Liu, X.,Demeler, B.,Ha, Y. The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. Biochemistry 2011 50 5453 5464 3QN2 21636896 Structure-based design of a disulfide-linked oligomeric form of the Simian Virus 40 (SV40) large T antigen DNA binding domain 2011-02-07 2011-06-01 Meinke, G.,Phelan, P.,Fradet-Turcotte, A.,Archambault, J.,Bullock, P.A. Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain. Acta Crystallogr.,Sect.D 2011 67 560 567 3QTL 21541315 Structural Basis for Dual-inhibition Mechanism of a Non-classical Kazal-type Serine Protease Inhibitor from Horseshoe Crab in Complex with Subtilisin 2011-02-23 2011-06-01 Shenoy, R.T.,Thangamani, S.,Velazquez-Campoy, A.,Ho, B.,Ding, J.L.,Sivaraman, J. Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin. Plos One 2011 6 0 0 3QU3 21596780 Crystal structure of IRF-7 DBD apo form 2011-02-23 2011-06-01 De Ioannes, P.,Escalante, C.R.,Aggarwal, A.K. Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding. Nucleic Acids Res. 2011 39 7300 7307 3QZV 21596426 Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide 2011-03-07 2011-06-01 Ruthenburg, A.J.,Li, H.,Milne, T.A.,Dewell, S.,McGinty, R.K.,Yuen, M.,Ueberheide, B.,Dou, Y.,Muir, T.W.,Patel, D.J.,Allis, C.D. Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.) 2011 145 692 706 3RNK Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain 2011-04-22 2011-06-01 Lazar-Molnar, E.,Ramagopal, U.A.,Cao, E.,Nathenson, S.G.,Almo, S.C. 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Protein Sci. 2011 20 1145 1154 3RDO 21520321 Crystal structure of R7-2 streptavidin complexed with biotin 2011-04-01 2011-07-06 Magalhaes, M.L.,Czekster, C.M.,Guan, R.,Malashkevich, V.N.,Almo, S.C.,Levy, M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci. 2011 20 1145 1154 3RDQ 21520321 Crystal structure of R7-2 streptavidin complexed with desthiobiotin 2011-04-01 2011-07-06 Magalhaes, M.L.,Czekster, C.M.,Guan, R.,Malashkevich, V.N.,Almo, S.C.,Levy, M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci. 2011 20 1145 1154 3RDS 21520321 Crystal structure of the refolded R7-2 streptavidin 2011-04-01 2011-07-06 Magalhaes, M.L.,Czekster, C.M.,Guan, R.,Malashkevich, V.N.,Almo, S.C.,Levy, M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci. 2011 20 1145 1154 3RDU 21520321 Crystal structure of R7-2 streptavidin complexed with PEG 2011-04-01 2011-07-06 Magalhaes, M.L.,Czekster, C.M.,Guan, R.,Malashkevich, V.N.,Almo, S.C.,Levy, M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci. 2011 20 1145 1154 3RDX 21520321 Crystal structure of ligand-free R7-2 streptavidin 2011-04-02 2011-07-06 Magalhaes, M.L.,Czekster, C.M.,Guan, R.,Malashkevich, V.N.,Almo, S.C.,Levy, M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci. 2011 20 1145 1154 3RE5 21520321 Crystal structure of R4-6 streptavidin 2011-04-02 2011-07-06 Magalhaes, M.L.,Czekster, C.M.,Guan, R.,Malashkevich, V.N.,Almo, S.C.,Levy, M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci. 2011 20 1145 1154 3RE6 21520321 Crystal structure of R4-6 streptavidin 2011-04-02 2011-07-06 Magalhaes, M.L.,Czekster, C.M.,Guan, R.,Malashkevich, V.N.,Almo, S.C.,Levy, M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Sci. 2011 20 1145 1154 3SGL 23617613 The crystal structure of MnmC from Yersinia pestis bound with FAD and SAM 2011-06-15 2011-07-06 Kim, J.,Almo, S.C. Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. Bmc Struct.Biol. 2013 13 5 5 3SJN Crystal structure of enolase Spea_3858 (target EFI-500646) from Shewanella pealeana with magnesium bound 2011-06-21 2011-07-06 Patskovsky, Y.,Kim, J.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. 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J.Struct.Funct.Genom. 2013 14 47 57 3T88 21830810 Crystal structure of Escherichia coli MenB in complex with substrate analogue, OSB-NCoA 2011-08-01 2011-08-24 Li, H.J.,Li, X.,Liu, N.,Zhang, H.,Truglio, J.J.,Mishra, S.,Kisker, C.,Garcia-Diaz, M.,Tonge, P.J. Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member. Biochemistry 2011 50 9532 9544 3T89 21830810 Crystal structure of Escherichia coli MenB, the 1,4-dihydroxy-2-naphthoyl-CoA synthase in vitamin K2 biosynthesis 2011-08-01 2011-08-24 Li, H.J.,Li, X.,Liu, N.,Zhang, H.,Truglio, J.J.,Mishra, S.,Kisker, C.,Garcia-Diaz, M.,Tonge, P.J. Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member. Biochemistry 2011 50 9532 9544 3T8A 21830810 Crystal structure of Mycobacterium tuberculosis MenB in complex with substrate analogue, OSB-NCoA 2011-08-01 2011-08-24 Li, H.J.,Li, X.,Liu, N.,Zhang, H.,Truglio, J.J.,Mishra, S.,Kisker, C.,Garcia-Diaz, M.,Tonge, P.J. Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member. Biochemistry 2011 50 9532 9544 3T8B 21830810 Crystal structure of Mycobacterium tuberculosis MenB with altered hexameric assembly 2011-08-01 2011-08-24 Li, H.J.,Li, X.,Liu, N.,Zhang, H.,Truglio, J.J.,Mishra, S.,Kisker, C.,Garcia-Diaz, M.,Tonge, P.J. Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member. Biochemistry 2011 50 9532 9544 2YIF 21745821 Crystal structure of a F. nucleatum FMN riboswitch - Free state 2011-05-12 2011-08-31 Vicens, Q.,Mondragon, E.,Batey, R.T. Molecular Sensing by the Aptamer Domain of the Fmn Riboswitch: A General Model for Ligand Binding by Conformational Selection. Nucleic Acids Res. 2011 39 8586 0 3TCS Crystal structure of a putative racemase from Roseobacter denitrificans 2011-08-09 2011-08-31 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of a putative racemase from Roseobacter denitrificans To be Published 0 0 0 0 3TF3 21870783 Crystal structure of metal-free Human Arginase I 2011-08-15 2011-08-31 D'Antonio, E.L.,Christianson, D.W. Crystal structures of complexes with cobalt-reconstituted human arginase I. Biochemistry 2011 50 8018 8027 3TFO Crystal structure of a putative 3-oxoacyl-(acyl-carrier-protein) reductase from Sinorhizobium meliloti 2011-08-16 2011-08-31 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a putative 3-oxoacyl-(acyl-carrier-protein) reductase from Sinorhizobium meliloti To be Published 0 0 0 0 3TG9 The crystal structure of penicillin binding protein from Bacillus halodurans 2011-08-17 2011-08-31 Zhang, Z.,Satyanarayana, L.,Almo, S.C.,Swaminathan, S. The crystal structure of penicillin binding protein from Bacillus halodurans To be Published 0 0 0 0 3OQ0 Crystal Structure of motif N of Saccharomyces cerevisiae Dbf4 2010-09-02 2011-09-07 Matthews, L.A.,Jones, D.R.,Prasad, A.A.,Duncker, B.P.,Guarne, A. Crystal Structure of Saccharomyces cerevisiae Dbf4-motif N To be Published 0 0 0 0 3OQ4 Crystal Structure of motif N of Saccharomyces cerevisiae Dbf4 2010-09-02 2011-09-07 Matthews, L.A.,Jones, D.R.,Prasad, A.A.,Duncker, B.P.,Guarne, A. Crystal Structure of Saccharomyces cerevisiae Dbf4-motif N To be Published 0 0 0 0 3R9M 21889351 Crystal structure of the Brox Bro1 domain 2011-03-25 2011-09-14 Sette, P.,Mu, R.,Dussupt, V.,Jiang, J.,Snyder, G.,Smith, P.,Xiao, T.S.,Bouamr, F. The Phe105 Loop of Alix Bro1 Domain Plays a Key Role in HIV-1 Release. Structure 2011 19 1485 1495 3TH7 21870783 Crystal structure of unliganded Co2+2-HAI (pH 7.0) 2011-08-18 2011-09-14 D'Antonio, E.L.,Christianson, D.W. Crystal structures of complexes with cobalt-reconstituted human arginase I. Biochemistry 2011 50 8018 8027 3THE 21870783 Crystal structure of Co2+2-HAI (pH 8.5) 2011-08-18 2011-09-14 D'Antonio, E.L.,Christianson, D.W. Crystal structures of complexes with cobalt-reconstituted human arginase I. Biochemistry 2011 50 8018 8027 3THH 21870783 Crystal structure of the Co2+2-HAI-ABH complex 2011-08-19 2011-09-14 D'Antonio, E.L.,Christianson, D.W. Crystal structures of complexes with cobalt-reconstituted human arginase I. Biochemistry 2011 50 8018 8027 3THJ 21870783 Crystal structure of the Co2+2-HAI-L-Orn complex 2011-08-19 2011-09-14 D'Antonio, E.L.,Christianson, D.W. Crystal structures of complexes with cobalt-reconstituted human arginase I. Biochemistry 2011 50 8018 8027 2XR7 22610270 Crystal Structure of Nicotiana tabacum malonyltransferase (NtMat1) complexed with malonyl-coa 2010-09-11 2011-09-21 Manjasetty, B.A.,Yu, X.H.,Panjikar, S.,Taguchi, G.,Chance, M.R.,Li, C.J. Structural Basis for Modification of Flavonol and Naphthol Glucoconjugates by Nicotiana Tabacum Malonyltransferase (Ntmat1). Planta 2012 236 781 0 3RAA 21900159 Structural studies of AAV8 capsid transitions associated with endosomal trafficking 2011-03-27 2011-09-21 Nam, H.J.,Gurda, B.L.,McKenna, R.,Potter, M.,Byrne, B.,Salganik, M.,Muzyczka, N.,Agbandje-McKenna, M. Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking. J.Virol. 2011 85 11791 11799 3S4S 21900604 Crystal structure of CD4 mutant bound to HLA-DR1 2011-05-20 2011-09-21 Wang, X.X.,Li, Y.,Yin, Y.,Mo, M.,Wang, Q.,Gao, W.,Wang, L.,Mariuzza, R.A. Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc.Natl.Acad.Sci.USA 2011 108 15960 15965 3S5L 21900604 Crystal structure of CD4 mutant bound to HLA-DR1 2011-05-23 2011-09-21 Wang, X.X.,Li, Y.,Yin, Y.,Mo, M.,Wang, Q.,Gao, W.,Wang, L.,Mariuzza, R.A. Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc.Natl.Acad.Sci.USA 2011 108 15960 15965 3TOT Crystal structure of GLUTATHIONE TRANSFERASE (TARGET EFI-501058) from Ralstonia solanacearum GMI1000 2011-09-06 2011-09-21 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Washington, R.D.S.E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal structure of GLUTATHIONE S-TRANSFERASE from Ralstonia solanacearum To be Published 0 0 0 0 3TOU Crystal structure of GLUTATHIONE TRANSFERASE (TARGET EFI-501058) from Ralstonia solanacearum GMI1000 with GSH bound 2011-09-06 2011-09-21 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Washington, R.D.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal structure of GLUTATHIONE S-TRANSFERASE from Ralstonia solanacearum To be Published 0 0 0 0 3TOX Crystal structure of a short chain dehydrogenase in complex with NAD(P) from Sinorhizobium meliloti 1021 2011-09-06 2011-09-21 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a short chain dehydrogenase in complex with NAD(P) from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3TOY CRYSTAL STRUCTURE OF ENOLASE BRADO_4202 (TARGET EFI-501651) FROM Bradyrhizobium sp. ORS278 WITH CALCIUM AND ACETATE BOUND 2011-09-06 2011-09-21 Patskovsky, Y.,Kim, J.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammond, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. CRYSTAL STRUCTURE OF MANDELATE RACEMASE FROM Bradyrhizobium sp. ORS278 To be Published 0 0 0 0 3OZC Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pCl-phenylthioDADMeImmA 2010-09-24 2011-09-28 Ho, M.,Guan, R.,Almo, S.C.,Schramm, V.L. Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase to be published 0 0 0 0 3OZD Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase in complex with pCl-phenylthioDADMeImmA 2010-09-24 2011-09-28 Ho, M.,Guan, R.,Almo, S.C.,Schramm, V.L. Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase to be published 0 0 0 0 3OZE Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase 2010-09-24 2011-09-28 Ho, M.,Guan, R.,Almo, S.C.,Schramm, V.L. Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase to be published 0 0 0 0 3OZF 22726686 Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine 2010-09-24 2011-09-28 Hazleton, K.Z.,Ho, M.C.,Cassera, M.B.,Clinch, K.,Crump, D.R.,Rosario, I.,Merino, E.F.,Almo, S.C.,Tyler, P.C.,Schramm, V.L. Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase. Chem.Biol. 2012 19 721 730 3OZG 22726686 Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with S-SerMe-ImmH phosphonate 2010-09-24 2011-09-28 Hazleton, K.Z.,Ho, M.C.,Cassera, M.B.,Clinch, K.,Crump, D.R.,Rosario, I.,Merino, E.F.,Almo, S.C.,Tyler, P.C.,Schramm, V.L. Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase. Chem.Biol. 2012 19 721 730 3R9Z 21911368 Crystal Structure of StWhy2 K67A (form II) 2011-03-26 2011-09-28 Cappadocia, L.,Parent, J.S.,Zampini, E.,Lepage, E.,Sygusch, J.,Brisson, N. A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Res. 2012 40 258 269 3RA0 21911368 Crystal Structure of a StWhy2 K67A-dT32 complex 2011-03-26 2011-09-28 Cappadocia, L.,Parent, J.S.,Zampini, E.,Lepage, E.,Sygusch, J.,Brisson, N. A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Res. 2012 40 258 269 3TFW Crystal structure of a putative O-methyltransferase from Klebsiella pneumoniae 2011-08-16 2011-09-28 Satyanarayana, L.,Almo, S.C.,Swaminathan, S. Crystal structure of a putative O-methyltransferase from Klebsiella pneumoniae To be Published 0 0 0 0 3TFX Crystal structure of Orotidine 5'-phosphate decarboxylase from Lactobacillus acidophilus 2011-08-16 2011-09-28 Satyanarayana, L.,Almo, S.C.,Swaminathan, S. Crystal structure of Orotidine 5'-phosphate decarboxylase from Lactobacillus acidophilus To be Published 0 0 0 0 3TPC Crystal structure of a hypothtical protein SMa1452 from Sinorhizobium meliloti 1021 2011-09-07 2011-09-28 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a hypothtical protein SMa1452 from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3TQI 26033498 Structure of the GMP synthase (guaA) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQM 26033498 Structure of an ribosomal subunit interface protein from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQP 26033498 Structure of an enolase (eno) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQQ 26033498 Structure of the methionyl-tRNA formyltransferase (fmt) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TR5 26033498 Structure of a peptide chain release factor 3 (prfC) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TR9 26033498 Structure of a dihydropteroate synthase (folP) in complex with pteroic acid from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TRE 26033498 Structure of a translation elongation factor P (efp) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TTE Crystal structure of enolase brado_4202 (target EFI-501651) from Bradyrhizobium complexed with magnesium and mandelic acid 2011-09-14 2011-09-28 Patskovsky, Y.,Kim, J.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammond, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Mandelate Racemase from Bradyrhizobium Sp. Ors278 To be Published 0 0 0 0 4A21 21949126 Structure of Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase bound to sulfate 2011-09-21 2011-10-05 De La Paz Santangelo, M.,Gest, P.M.,Guerin, M.E.,Coincon, M.,Pham, H.,Ryan, G.,Puckett, S.E.,Spencer, J.S.,Gonzalez-Juarrero, M.,Daher, R.,Lenaerts, A.J.,Schnappinger, D.,Therisod, M.,Ehrt, S.,Sygusch, J.,Jackson, M. Glycolytic and Non-Glycolytic Functions of the Fructose-1,6-Bisphosphate Aldolase of Mycobacterium Tuberculosis, an Essential Enzyme Produced by Replicating and Non-Replicating Bacilli J.Biol.Chem. 2011 286 40219 0 3RF4 21944748 Ancylostoma ceylanicum mif in complex with furosemide 2011-04-05 2011-10-12 Cho, Y.,Vermeire, J.J.,Merkel, J.S.,Leng, L.,Du, X.,Bucala, R.,Cappello, M.,Lolis, E. Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors. Chem.Biol. 2011 18 1089 1101 3S9H 21923197 RB69 DNA Polymerase Triple Mutant(L561A/S565G/Y567A) ternary complex with dUpNpp and a dideoxy-terminated primer in the presence of Ca2+ 2011-06-01 2011-10-12 Xia, S.,Wang, M.,Blaha, G.,Konigsberg, W.H.,Wang, J. Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase. Biochemistry 2011 50 9114 9124 3SNN 21923197 RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dCTP Opposite dG in the presence of Mg2+ 2011-06-29 2011-10-12 Xia, S.,Wang, M.,Blaha, G.,Konigsberg, W.H.,Wang, J. Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase. Biochemistry 2011 50 9114 9124 3SYA 21962516 Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium and PIP2 2011-07-16 2011-10-12 Whorton, M.R.,Mackinnon, R. Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.) 2011 147 199 208 3SYC 21962516 Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) D228N mutant 2011-07-16 2011-10-12 Whorton, M.R.,Mackinnon, R. Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.) 2011 147 199 208 3SYP 21962516 Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) R201A mutant 2011-07-18 2011-10-12 Whorton, M.R.,Mackinnon, R. Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.) 2011 147 199 208 3TU9 24900268 Crystal structure of rabbit muscle aldolase bound with 5-O-methyl mannitol 1,6-phosphate 2011-09-16 2011-10-12 Mabiala-Bassiloua, C.G.,Arthus-Cartier, G.,Hannaert, V.,Therisod, H.,Sygusch, J.,Therisod, M. Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases. ACS Med Chem Lett 2011 2 804 808 4A22 21949126 Structure of Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase bound to N-(4-hydroxybutyl)- glycolohydroxamic acid bis- phosphate 2011-09-21 2011-10-12 de la Paz Santangelo, M.,Gest, P.M.,Guerin, M.E.,Coincon, M.,Pham, H.,Ryan, G.,Puckett, S.E.,Spencer, J.S.,Gonzalez-Juarrero, M.,Daher, R.,Lenaerts, A.J.,Schnappinger, D.,Therisod, M.,Ehrt, S.,Sygusch, J.,Jackson, M. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. J. Biol. Chem. 2011 286 40219 40231 3TVU 21953464 Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 3 2011-09-20 2011-10-19 Rajamohan, F.,Marr, E.,Reyes, A.R.,Landro, J.A.,Anderson, M.D.,Corbett, J.W.,Dirico, K.J.,Harwood, J.H.,Tu, M.,Vajdos, F.F. Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion. J.Biol.Chem. 2011 286 41510 41519 3TZ3 21953464 Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 2 2011-09-26 2011-10-19 Rajamohan, F.,Marr, E.,Reyes, A.R.,Landro, J.A.,Anderson, M.D.,Corbett, J.W.,Dirico, K.J.,Harwood, J.H.,Tu, M.,Vajdos, F.F. Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion. J.Biol.Chem. 2011 286 41510 41519 3U3X Crystal structure of a putative oxidoreductase from Sinorhizobium meliloti 1021 2011-10-06 2011-10-19 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a putative oxidoreductase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3U4F Crystal structure of a mandelate racemase (muconate lactonizing enzyme family protein) from Roseovarius nubinhibens 2011-10-07 2011-10-19 Eswaramoorthy, S.,Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a mandelate racemase (muconate lactonizing enzyme family protein) from Roseovarius nubinhibens To be Published 2011 0 0 0 3U4J Crystal structure of NAD-dependent aldehyde dehydrogenase from Sinorhizobium meliloti 2011-10-08 2011-10-19 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of NAD-dependent aldehyde dehydrogenase from Sinorhizobium meliloti To be Published 0 0 0 0 3U5R Crystal structure of a hypothetical protein SMc02350 from Sinorhizobium meliloti 1021 2011-10-11 2011-10-19 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a hypothetical protein SMc02350 from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3SWW 21996520 Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one 2011-07-14 2011-10-26 Wang, W.,Devasthale, P.,Wang, A.,Harrity, T.,Egan, D.,Morgan, N.,Cap, M.,Fura, A.,Klei, H.E.,Kish, K.,Weigelt, C.,Sun, L.,Levesque, P.,Li, Y.X.,Zahler, R.,Kirby, M.S.,Hamann, L.G. 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg.Med.Chem.Lett. 2011 21 6646 6651 3SX4 21996520 Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one 2011-07-14 2011-10-26 Wang, W.,Devasthale, P.,Wang, A.,Harrity, T.,Egan, D.,Morgan, N.,Cap, M.,Fura, A.,Klei, H.E.,Kish, K.,Weigelt, C.,Sun, L.,Levesque, P.,Li, Y.X.,Zahler, R.,Kirby, M.S.,Hamann, L.G. 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg.Med.Chem.Lett. 2011 21 6646 6651 3TS7 23493556 CRYSTAL STRUCTURE OF FARNESYL DIPHOSPHATE SYNTHASE (TARGET EFI-501951) FROM Methylococcus capsulatus 2011-09-12 2011-10-26 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3TW9 Crystal structure of gluconate dehydratase (TARGET EFI-501679) from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 2011-09-21 2011-10-26 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Gluconate Dehydratase from Salmonella Enterica P125109 To be Published 0 0 0 0 3TWA Crystal structure of gluconate dehydratase (TARGET EFI-501679) from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 complexed with magnesium and glycerol 2011-09-21 2011-10-26 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Gluconate Dehydratase from Salmonella Enterica P125109 To be Published 0 0 0 0 3TWB Crystal structure of gluconate dehydratase (TARGET EFI-501679) from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 complexed with magnesium and gluconic acid 2011-09-21 2011-10-26 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Gluconate Dehydratase from Salmonella Enterica P125109 To be Published 0 0 0 0 3T81 Crystal Structure of diiron adenine deaminase 2011-08-01 2011-11-02 Bagaria, A.,Kumaran, D.,Burley, S.K.,Swaminathan, S. Crystal Structure of diiron adenine deaminase TO BE PUBLISHED 0 0 0 0 3T8L 21998098 Crystal Structure of adenine deaminase with Mn/Fe 2011-08-01 2011-11-02 Kamat, S.S.,Holmes-Hampton, G.P.,Bagaria, A.,Kumaran, D.,Tichy, S.E.,Gheyi, T.,Zheng, X.,Bain, K.,Groshong, C.,Emtage, S.,Sauder, J.M.,Burley, S.K.,Swaminathan, S.,Lindahl, P.A.,Raushel, F.M. The catalase activity of diiron adenine deaminase. Protein Sci. 2011 20 2080 2094 3UAP Crystal structure of glutathione transferase (TARGET EFI-501774) from methylococcus capsulatus str. bath 2011-10-21 2011-11-02 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glutathione S-Transferase from Methylococcus Capsulatus To be Published 0 0 0 0 3UAR Crystal structure of glutathione transferase (TARGET EFI-501774) from methylococcus capsulatus str. bath with gsh bound 2011-10-21 2011-11-02 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glutathione S-Transferase from Methylococcus Capsulatus To be Published 0 0 0 0 3PHB Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG 2010-11-03 2011-11-09 Ho, M.,Cassera, M.B.,Murkin, A.S.,Almo, S.C.,Schramm, V.L. Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG to be published 0 0 0 0 3PHC Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase in complex with DADMe-ImmG 2010-11-03 2011-11-09 Ho, M.,Edwards, A.A.,Almo, S.C.,Schramm, V.L. Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase in complex with DADMe-ImmG To be Published 0 0 0 0 3S5S Crystal structure of putative mandelate racemase/muconate lactonizing enzyme (PSI/COM target 200551) from Sorangium cellulosum 2011-05-23 2011-11-09 Ramagopal, U.A.,Toro, R.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) Crystal structure of putative mandelate racemase/muconate lactonizing enzyme (PSI/COM target 200551) from Sorangium cellulosum To be published 0 0 0 0 3TO9 22020126 Crystal structure of yeast Esa1 E338Q HAT domain bound to coenzyme A with active site lysine acetylated 2011-09-04 2011-11-09 Yuan, H.,Rossetto, D.,Mellert, H.,Dang, W.,Srinivasan, M.,Johnson, J.,Hodawadekar, S.,Ding, E.C.,Speicher, K.,Abshiru, N.,Perry, R.,Wu, J.,Yang, C.,Zheng, Y.G.,Speicher, D.W.,Thibault, P.,Verreault, A.,Johnson, F.B.,Berger, S.L.,Sternglanz, R.,McMahon, S.B.,Cote, J.,Marmorstein, R. MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J. 2011 31 58 70 3TOA 22020126 Human MOF crystal structure with active site lysine partially acetylated 2011-09-04 2011-11-09 Yuan, H.,Rossetto, D.,Mellert, H.,Dang, W.,Srinivasan, M.,Johnson, J.,Hodawadekar, S.,Ding, E.C.,Speicher, K.,Abshiru, N.,Perry, R.,Wu, J.,Yang, C.,Zheng, Y.G.,Speicher, D.W.,Thibault, P.,Verreault, A.,Johnson, F.B.,Berger, S.L.,Sternglanz, R.,McMahon, S.B.,Cote, J.,Marmorstein, R. MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J. 2011 31 58 70 3TVI 25170437 Crystal structure of Clostridium acetobutylicum aspartate kinase (CaAK): An important allosteric enzyme for industrial amino acids production 2011-09-20 2011-11-09 Manjasetty, B.A.,Chance, M.R.,Burley, S.K.,Panjikar, S.,Almo, S.C. Crystal structure of Clostridium acetobutylicum Aspartate kinase (CaAK): An important allosteric enzyme for amino acids production. Biotechnol Rep (Amst) 2014 3 73 85 3U5T The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from Sinorhizobium meliloti 2011-10-11 2011-11-09 Zhang, Z.,Almo, S.C.,Swaminathan, S. The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from Sinorhizobium meliloti To be Published 0 0 0 0 3U9L The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) from Sinorhizobium meliloti 2011-10-19 2011-11-09 Zhang, Z.,Almo, S.C.,Swaminathan, S. The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) from Sinorhizobium meliloti TO BE PUBLISHED 0 0 0 0 3UBK Crystal structure of glutathione transferase (TARGET EFI-501770) from leptospira interrogans 2011-10-24 2011-11-09 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glutathione S-Transferase from Leptospira Interrogans To be Published 0 0 0 0 3UBL Crystal structure of glutathione transferase (TARGET EFI-501770) from leptospira interrogans with gsh bound 2011-10-24 2011-11-09 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glutathione S-Transferase from Leptospira Interrogans To be Published 0 0 0 0 3UBO The crystal structure of adenosine kinase from Sinorhizobium meliloti 2011-10-24 2011-11-09 Zhang, Z.,Almo, S.C.,Swaminathan, S. The crystal structure of adenosine kinase from Sinorhizobium meliloti To be Published 0 0 0 0 3QXA 22084083 HLA-DR1 bound with CLIP peptide 2011-03-01 2011-11-16 Painter, C.A.,Negroni, M.P.,Kellersberger, K.A.,Zavala-Ruiz, Z.,Evans, J.E.,Stern, L.J. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc.Natl.Acad.Sci.USA 2011 108 19329 19334 3QXD 22084083 F54C HLA-DR1 bound with CLIP peptide 2011-03-01 2011-11-16 Painter, C.A.,Negroni, M.P.,Kellersberger, K.A.,Zavala-Ruiz, Z.,Evans, J.E.,Stern, L.J. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc.Natl.Acad.Sci.USA 2011 108 19329 19334 3TIX 22081013 Crystal structure of the Chp1-Tas3 complex core 2011-08-22 2011-11-16 Schalch, T.,Job, G.,Shanker, S.,Partridge, J.F.,Joshua-Tor, L. The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nat.Struct.Mol.Biol. 2011 18 1351 1357 3UCA 23493556 Crystal structure of isoprenoid synthase (target EFI-501974) from clostridium perfringens 2011-10-26 2011-11-16 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3ZXP 22162750 Structural and Functional Analyses of the Bro1 Domain Protein BROX 2011-08-13 2011-11-16 Zhai, Q.,Landesman, M.B.,Robinson, H.,Sundquist, W.I.,Hill, C.P. Structure of the Bro1 Domain Protein Brox and Functional Analyses of the Alix Bro1 Domain in HIV-1 Budding. Plos One 2011 6 27466 0 3B23 22053189 Crystal structure of thrombin-variegin complex: Insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors 2011-07-20 2011-11-23 Koh, C.Y.,Kumar, S.,Kazimirova, M.,Nuttall, P.A.,Radhakrishnan, U.P.,Kim, S.,Jagadeeswaran, P.,Imamura, T.,Mizuguchi, J.,Iwanaga, S.,Swaminathan, K.,Kini, R.M. Crystal structure of thrombin in complex with s-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors Plos One 2011 6 0 0 3T6G 22081014 Structure of the complex between NSP3 (SHEP1) and p130Cas 2011-07-28 2011-11-23 Mace, P.D.,Wallez, Y.,Dobaczewska, M.K.,Lee, J.J.,Robinson, H.,Pasquale, E.B.,Riedl, S.J. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nat.Struct.Mol.Biol. 2011 18 1381 1387 3TS5 22067157 Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin 2011-09-12 2011-11-23 Senthil Kumar, V.S.,O'Neall-Hennessey, E.,Reshetnikova, L.,Brown, J.H.,Robinson, H.,Szent-Gyorgyi, A.G.,Cohen, C. Crystal structure of a phosphorylated light chain domain of scallop smooth-muscle Myosin. Biophys.J. 2011 101 2185 2189 3TUY 22067157 Phosphorylated Light Chain Domain of Scallop smooth Muscle Myosin 2011-09-19 2011-11-23 Senthil Kumar, V.S.,O'Neall-Hennessey, E.,Reshetnikova, L.,Brown, J.H.,Robinson, H.,Szent-Gyorgyi, A.G.,Cohen, C. Crystal structure of a phosphorylated light chain domain of scallop smooth-muscle Myosin. Biophys.J. 2011 101 2185 2189 3UF0 Crystal structure of a putative NAD(P) dependent gluconate 5-dehydrogenase from Beutenbergia cavernae(EFI target EFI-502044) with bound NADP (low occupancy) 2011-10-31 2011-11-23 Vetting, M.W.,Toro, R.,Bhosle, R.,Hillerich, B.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of a putative NAD(P) dependent gluconate 5-dehydrogenase from Beutenbergia cavernae(EFI target EFI-502044) with bound NADP (low occupancy) To be Published 0 0 0 0 3UHJ Crystal structure of a probable glycerol dehydrogenase from Sinorhizobium meliloti 1021 2011-11-03 2011-11-23 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a probable glycerol dehydrogenase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3UIF CRYSTAL STRUCTURE OF putative sulfonate ABC transporter, periplasmic sulfonate-binding protein SsuA from Methylobacillus flagellatus KT 2011-11-04 2011-11-23 Malashkevich, V.N.,Bonanno, J.B.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. CRYSTAL STRUCTURE OF putative sulfonate ABC transporter, periplasmic sulfonate-binding protein SsuA from Methylobacillus flagellatus KT To be Published 0 0 0 0 3UJ2 CRYSTAL STRUCTURE OF AN ENOLASE FROM ANAEROSTIPES CACCAE (EFI TARGET EFI-502054) WITH BOUND MG AND SULFATE 2011-11-07 2011-11-23 Vetting, M.W.,Toro, R.,Bhosle, R.,Hillerich, B.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) CRYSTAL STRUCTURE OF AN ENOLASE FROM ANAEROSTIPES CACCAE (EFI TARGET EFI-502054) WITH BOUND MG AND SULFATE to be published 0 0 0 0 3NTT 23926356 Structural insights of Adeno-Associated virus 5. A gene therapy Vector for Cystic Fibrosis 2010-07-05 2011-12-07 Govindasamy, L.,DiMattia, M.A.,Gurda, B.L.,Halder, S.,McKenna, R.,Chiorini, J.A.,Muzyczka, N.,Zolotukhin, S.,Agbandje-McKenna, M. Structural insights into adeno-associated virus serotype 5. J.Virol. 2013 87 11187 11199 3U6N 22139424 Open Structure of the BK channel Gating Ring 2011-10-12 2011-12-07 Yuan, P.,Leonetti, M.D.,Hsiung, Y.,Mackinnon, R. Open structure of the Ca(2+) gating ring in the high-conductance Ca(2+)-activated K(+) channel. Nature 2011 481 94 97 3UGO 22136875 Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) 2011-11-02 2011-12-07 Feklistov, A.,Darst, S.A. Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.) 2011 147 1257 1269 3UOG Crystal structure of putative Alcohol dehydrogenase from Sinorhizobium meliloti 1021 2011-11-16 2011-12-07 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. Crystal structure of putative Alcohol dehydrogenase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3N6I Crystal Structure of BlaC-E166A covalently bound with 6-aminopenicillian 2010-05-25 2011-12-14 Tremblay, L.W.,Blanchard, J.S. The Structure Activity Relationship of BlaC with all classes of beta-lactams To be Published 0 0 0 0 3N8L Crystal Structure of BlaC-E166A covalently bound with Ampicillin 2010-05-28 2011-12-14 Tremblay, L.W.,Blanchard, J.S. Structures of BlaC-E166A covalently bound to beta-lactams from all classes. To be Published 0 0 0 0 3N8R Crystal Structure of BlaC-E166A covalently bound with Carbenicillin 2010-05-28 2011-12-14 Tremblay, L.W.,Blanchard, J.S. BlaC-E166A bound with beta-lactams from all classes To be Published 0 0 0 0 3NBL Crystal Structure of BlaC-E166A covalently bound with Cefuroxime 2010-06-03 2011-12-14 Tremblay, L.W.,Blanchard, J.S. BlaC-E166A covalently bound with cephalosporins and penicillins To be Published 0 0 0 0 3NC8 Crystal Structure of BlaC-E166A covalently bound with Mecillinam 2010-06-04 2011-12-14 Tremblay, L.W.,Blanchard, J.S. BlaC-E166A covalently bound with cephalosporins and penicillins To be Published 0 0 0 0 3NCK Crystal Structure of BlaC-E166A covalently bound with Nafcillin 2010-06-04 2011-12-14 Tremblay, L.W.,Blanchard, J.S. BlaC-E166A covalently bound with cephalosporins and penicillins To be Published 0 0 0 0 3NDE Crystal Structure of BlaC-E166A covalently bound with Cephalotin 2010-06-07 2011-12-14 Tremblay, L.W.,Blanchard, J.S. BlaC-E166A covalently bound with cephalosporins and penicillins To be Published 0 0 0 0 3NDG Crystal Structure of BlaC-E166A covalently bound with Methicillin 2010-06-07 2011-12-14 Tremblay, L.W.,Blanchard, J.S. BlaC-E166A covalently bound with cephalosporins and penicillins To be Published 0 0 0 0 3U9R 22158123 Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC), beta subunit 2011-10-19 2011-12-14 Huang, C.S.,Ge, P.,Zhou, Z.H.,Tong, L. An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature 2012 481 219 223 3U9S 22158123 Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, CoA complex 2011-10-19 2011-12-14 Huang, C.S.,Ge, P.,Zhou, Z.H.,Tong, L. An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature 2012 481 219 223 3U9T 22158123 Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, free enzyme 2011-10-19 2011-12-14 Huang, C.S.,Ge, P.,Zhou, Z.H.,Tong, L. An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature 2012 481 219 223 3URH Crystal structure of a dihydrolipoamide dehydrogenase from Sinorhizobium meliloti 1021 2011-11-22 2011-12-14 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a dihydrolipoamide dehydrogenase from Sinorhizobium meliloti 1021 TO BE PUBLISHED 0 0 0 0 3US8 Crystal Structure of an isocitrate dehydrogenase from Sinorhizobium meliloti 1021 2011-11-23 2011-12-14 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal Structure of an isocitrate dehydrogenase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3RJO 22355701 Crystal Structure of ERAP1 Peptide Binding Domain 2011-04-15 2011-12-21 Gandhi, A.,Lakshminarasimhan, D.,Sun, Y.,Guo, H.C. Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1. Sci Rep 2011 1 186 186 3UO8 22158899 Crystal structure of the MALT1 paracaspase (P1 form) 2011-11-16 2011-12-21 Yu, J.W.,Jeffrey, P.D.,Ha, J.Y.,Yang, X.,Shi, Y. Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Proc.Natl.Acad.Sci.USA 2011 108 21004 21009 3UOA 22158899 Crystal structure of the MALT1 paracaspase (P21 form) 2011-11-16 2011-12-21 Yu, J.W.,Jeffrey, P.D.,Ha, J.Y.,Yang, X.,Shi, Y. Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Proc.Natl.Acad.Sci.USA 2011 108 21004 21009 3U2B 22181698 Structure of the Sox4 HMG domain bound to DNA 2011-10-03 2011-12-28 Jauch, R.,Ng, C.K.L.,Narasimhan, K.,Kolatkar, P.R. The crystal structure of the Sox4 HMG domain-DNA complex suggests a mechanism for positional interdependence in DNA recognition Biochem.J. 2012 443 39 47 3ULQ 22215984 Crystal Structure of the Anti-Activator RapF Complexed with the Response Regulator ComA DNA Binding Domain 2011-11-11 2012-01-04 Baker, M.D.,Neiditch, M.B. Structural basis of response regulator inhibition by a bacterial anti-activator protein. Plos Biol. 2011 9 0 0 3V76 The crystal structure of a flavoprotein from Sinorhizobium meliloti 2011-12-20 2012-01-04 Zhang, Z.,Almo, S.C.,Swaminathan, S. The crystal structure of a flavoprotein from Sinorhizobium meliloti TO BE PUBLISHED 0 0 0 0 3Q9D Crystal Structure of Cpn0803 from C. pneumoniae. 2011-01-07 2012-01-11 Stone, C.B.,Sugiman-Marangos, S.N.,Junop, M.S.,Mahony, J.B. Crystal Structure of Cpn0803 from C. pneumoniae. To be Published 0 0 0 0 3V7P Crystal structure of amidohydrolase nis_0429 (target efi-500396) from Nitratiruptor sp. sb155-2 2011-12-21 2012-01-11 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C. Crystal Structure of Amidohydrolase Nis_0429 (Target Efi-500319) from Nitratiruptor Sp. Sb155-2 To be Published 0 0 0 0 3V8B Crystal Structure of a 3-ketoacyl-ACP reductase from Sinorhizobium meliloti 1021 2011-12-22 2012-01-11 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal Structure of a 3-ketoacyl-ACP reductase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3VC7 Crystal Structure of a putative oxidoreductase from Sinorhizobium meliloti 1021 2012-01-03 2012-01-18 Ghosh, A.,Bhoshle, R.,Toro, R.,Gizzi, A.,Hillerich, B.,Almo, S.C. Crystal Structure of a putative oxidoreductase protein from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3QEW RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dDTP Opposite dT 2011-01-20 2012-01-25 Xia, S.,Konigsberg, W.H.,Wang, J. Hydrogen-Bonding Capability of Difluorotoluene Nucleoside in Replication Complexes To be Published 0 0 0 0 3VCN Crystal structure of mannonate dehydratase (target EFI-502209) from Caulobacter crescentus CB15 2012-01-04 2012-01-25 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of mannonate dehydratase from Caulobacter crescentus CB15 To be Published 0 0 0 0 3VDG Crystal structure of enolase MSMEG_6132 (TARGET EFI-502282) from Mycobacterium smegmatis str. MC2 155 complexed with formate and acetate 2012-01-05 2012-01-25 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of enolase MSMEG_6132 FROM Mycobacterium smegmatis To be Published 0 0 0 0 3VDI 22457093 Structure of the FMO protein from Pelodictyon phaeum 2012-01-05 2012-01-25 Tronrud, D.E.,Allen, J.P. Reinterpretation of the electron density at the site of the eighth bacteriochlorophyll in the FMO protein from Pelodictyon phaeum. Photosynth.Res. 2012 112 71 74 3VFC Crystal structure of enolase MSMEG_6132 (TARGET EFI-502282) from Mycobacterium smegmatis str. MC2 155 complexed with tartrate 2012-01-09 2012-01-25 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of enolase MSMEG_6132 from Mycobacterium smegmatis To be Published 0 0 0 0 4D8L 22475079 Crystal structure of the 2-pyrone-4,6-dicarboxylic acid hydrolase from sphingomonas paucimobilis 2012-01-10 2012-01-25 Hobbs, M.E.,Malashkevich, V.,Williams, H.J.,Xu, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Raushel, F.M. Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation. Biochemistry 2012 51 3497 3507 4DA9 Crystal structure of putative Short-chain dehydrogenase/reductase from Sinorhizobium meliloti 1021 2012-01-12 2012-01-25 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. Crystal structure of putative Short-chain dehydrogenase/reductase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3AWD 22040731 Crystal structure of gox2181 2011-03-18 2012-02-01 Liu, X.,Yuan, Z.,Adam Yuan, Y.,Lin, J.,Wei, D. Biochemical and structural analysis of Gox2181, a new member of the SDR superfamily from Gluconobacter oxydans. Biochem.Biophys.Res.Commun. 2011 415 410 415 3TXX Crystal structure of putrescine transcarbamylase from Enterococcus faecalis 2011-09-23 2012-02-01 Shi, D.,Yu, X.,Zhao, G.,Ho, J.,Lu, S.,Allewell, N.M.,Tuchman, M. Crystal structure of putrescine transcarbamylase from Enterococcus faecalis: Structural insights into the oligomeric assembly and the active site To be Published 0 0 0 0 3UIH 22244766 crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide 2011-11-04 2012-02-01 Du, J.,Kelly, A.E.,Funabiki, H.,Patel, D.J. Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin. Structure 2012 20 185 195 3VA8 Crystal structure of enolase FG03645.1 (target EFI-502278) from Gibberella zeae PH-1 complexed with magnesium, formate and sulfate 2011-12-29 2012-02-01 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of dehydratase FG03645.1 from Gibberella zeae PH-1 To be Published 0 0 0 0 3VC5 Crystal structure of enolase Tbis_1083(TARGET EFI-502310) FROM Thermobispora bispora DSM 43833 complexed with phosphate 2012-01-03 2012-02-01 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of enolase Tbis_1083 FROM Thermobispora bispora DSM 43833 To be Published 0 0 0 0 3VC6 Crystal structure of enolase Tbis_1083(TARGET EFI-502310) FROM Thermobispora bispora DSM 43833 complexed with magnesium and formate 2012-01-03 2012-02-01 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of enolase Tbis_1083 FROM Thermobispora bispora DSM 43833 To be Published 0 0 0 0 4DEJ Crystal structure of glutathione transferase-like protein IL0419 (Target EFI-501089) from Idiomarina loihiensis L2TR 2012-01-20 2012-02-01 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glutathione S-Transferase-Like Protein Il0419 from Idiomarina Loihiensis To be Published 0 0 0 0 4DFD Crystal structure of had family enzyme bt-2542 (target efi-501088) from bacteroides thetaiotaomicron, magnesium complex 2012-01-23 2012-02-01 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088) To be Published 0 0 0 0 3QNN 22616982 RB69 DNA Polymerase (Y567A) Ternary Complex with dGT Opposite 3tCo 2011-02-08 2012-02-08 Xia, S.,Beckman, J.,Wang, J.,Konigsberg, W.H. Using a Fluorescent Cytosine Analogue tC(o) To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA Polymerase. Biochemistry 2012 51 4609 4617 3QW5 22525749 Crystal structure of the protease domain of Botulinum Neurotoxin Serotype A with a peptide inhibitor RRGF 2011-02-26 2012-02-08 Kumar, G.,Kumaran, D.,Ahmed, S.A.,Swaminathan, S. Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling. Acta Crystallogr.,Sect.D 2012 68 511 520 3QW6 22525749 Crystal structure of the protease domain of Botulinum Neurotoxin Serotype A with a peptide inhibitor RYGC 2011-02-26 2012-02-08 Kumar, G.,Kumaran, D.,Ahmed, S.A.,Swaminathan, S. Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling. Acta Crystallogr.,Sect.D 2012 68 511 520 3QW7 22525749 Crystal structure of the protease domain of Botulinum Neurotoxin Serotype A with a peptide inhibitor RRFC 2011-02-27 2012-02-08 Kumar, G.,Kumaran, D.,Ahmed, S.A.,Swaminathan, S. Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling. Acta Crystallogr.,Sect.D 2012 68 511 520 3QW8 22525749 Crystal structure of the protease domain of Botulinum Neurotoxin Serotype A with a peptide inhibitor CRGC 2011-02-27 2012-02-08 Kumar, G.,Kumaran, D.,Ahmed, S.A.,Swaminathan, S. Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling. Acta Crystallogr.,Sect.D 2012 68 511 520 3TQ1 22154937 Human DNA Polymerase eta in binary complex with DNA 2011-09-08 2012-02-08 Ummat, A.,Silverstein, T.D.,Jain, R.,Buku, A.,Johnson, R.E.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Human DNA Polymerase Eta Is Pre-Aligned for dNTP Binding and Catalysis. J.Mol.Biol. 2012 415 627 634 4DGS The crystals structure of dehydrogenase from Rhizobium meliloti 2012-01-26 2012-02-08 Zhang, Z.,Almo, S.C.,Swaminathan, S. The crystals structure of dehydrogenase from Rhizobium meliloti To be Published 0 0 0 0 4DHD 23493556 Crystal structure of isoprenoid synthase A3MSH1 (TARGET EFI-501992) from Pyrobaculum calidifontis 2012-01-27 2012-02-08 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 3V8G 22343718 Crystal structure of an asymmetric trimer of a glutamate transporter homologue (GltPh) 2011-12-22 2012-02-15 Verdon, G.,Boudker, O. Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog. Nat.Struct.Mol.Biol. 2012 19 355 357 4DHG Crystal structure of enolase TBIS_1083(TARGET EFI-502310) from Thermobispora bispora dsm 43833, an open loop conformation 2012-01-27 2012-02-15 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Enolase Tbis_1083 from Thermobispora Bispora Dsm 43833 To be Published 0 0 0 0 4DLL Crystal structure of a 2-hydroxy-3-oxopropionate reductase from Polaromonas sp. JS666 2012-02-06 2012-02-15 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a 2-hydroxy-3-oxopropionate reductase from Polaromonas sp. JS666 To be Published 0 0 0 0 3TJZ 22304919 Crystal Structure of Arf1 Bound to the gamma/zeta-COP Core Complex 2011-08-25 2012-02-22 Yu, X.,Breitman, M.,Goldberg, J. A structure-based mechanism for arf1-dependent recruitment of coatomer to membranes. Cell(Cambridge,Mass.) 2012 148 530 542 3TS9 22314235 Crystal Structure of the MDA5 Helicase Insert Domain 2011-09-12 2012-02-22 Berke, I.C.,Modis, Y. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. Embo J. 2012 31 1714 1726 3TS9 22314235 Crystal Structure of the MDA5 Helicase Insert Domain 2011-09-12 2012-02-22 Berke, I.C.,Modis, Y. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. Embo J. 2012 31 1714 1726 3U4W 22344177 Src in complex with DNA-templated macrocyclic inhibitor MC4b 2011-10-10 2012-02-22 Georghiou, G.,Kleiner, R.E.,Pulkoski-Gross, M.,Liu, D.R.,Seeliger, M.A. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nat.Chem.Biol. 2012 8 366 374 3U51 22344177 Src in complex with DNA-templated macrocyclic inhibitor MC1 2011-10-10 2012-02-22 Georghiou, G.,Kleiner, R.E.,Pulkoski-Gross, M.,Liu, D.R.,Seeliger, M.A. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nat.Chem.Biol. 2012 8 366 374 3V93 22356915 unliganded structure of TcrPDEC1 catalytic domain 2011-12-23 2012-02-22 Wang, H.,Kunz, S.,Chen, G.,Seebeck, T.,Wan, Y.,Robinson, H.,Martinelli, S.,Ke, H. Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. J.Biol.Chem. 2012 287 11788 11797 3V94 TcrPDEC1 catalytic domain in complex with inhibitor wyq16 2011-12-23 2012-02-22 Wang, H.,Kunz, S.,Chen, G.,Seebeck, T.,Wan, Y.,Robinson, H.,Martinelli, S.,Ke, H. TcrPDEC1 catalytic domain in complex with inhibitor wyq16 To be Published 0 0 0 0 4DCC Crystal structure of had family enzyme bt-2542 from bacteroides thetaiotaomicron (target efi-501088) 2012-01-17 2012-02-22 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088) To be Published 0 0 0 0 4DN2 CRYSTAL STRUCTURE OF putative Nitroreductase from Geobacter metallireducens GS-15 2012-02-08 2012-02-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. CRYSTAL STRUCTURE OF putative Nitroreductase from Geobacter metallireducens GS-15 To be Published 0 0 0 0 4DN7 CRYSTAL STRUCTURE OF putative ABC transporter, ATP-binding protein from Methanosarcina mazei Go1 2012-02-08 2012-02-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. CRYSTAL STRUCTURE OF putative ABC transporter, ATP-binding protein from Methanosarcina mazei Go1 To be Published 0 0 0 0 4DN9 CRYSTAL STRUCTURE OF putative Antibiotic biosynthesis monooxygenase from Chloroflexus aurantiacus J-10-fl 2012-02-08 2012-02-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. CRYSTAL STRUCTURE OF putative Antibiotic biosynthesis monooxygenase from Chloroflexus aurantiacus J-10-fl To be Published 0 0 0 0 4DND Crystal structure of syntaxin 10 from Homo sapiens 2012-02-08 2012-02-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. Crystal structure of syntaxin 10 from Homo sapiens To be Published 0 0 0 0 4DNG Crystal structure of putative aldehyde dehydrogenase from Bacillus subtilis subsp. subtilis str. 168 2012-02-08 2012-02-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. Crystal structure of putative aldehyde dehydrogenase from Bacillus subtilis subsp. subtilis str. 168 To be Published 0 0 0 0 3Q0T Crystal structure of human dpp-iv in complex withsa-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5h-pyrrolo[3,4-b]pyridin-6(7h)-yl)acetate 2010-12-16 2012-02-29 Wang, W.,Devasthale, P.,Wang, A.,Egan, D.,Morgan, N.,Cap, M.,Fura, A.,Klei, H.E.,Kish, K.,Sun, L.,Levesque, P.,Zahler, R.,Kirby, M.,Hamann, L.G. Discovery of 7-oxo-pyrrolopyridines as potent and selective inhibitors of dpp4 To be Published 0 0 0 0 3RJ2 21715494 Structural and functional characterization of a novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus (SGIV) 2011-04-15 2012-02-29 Tran, B.N.,Chen, L.,Liu, Y.,Wu, J.,Velazquez-Campoy, A.,Sivaraman, J.,Hew, C.L. Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus J.Virol. 2011 85 9159 9166 3V62 22382979 Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164 2011-12-18 2012-02-29 Armstrong, A.A.,Mohideen, F.,Lima, C.D. Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature 2012 483 59 63 4DLF Crystal structure of an amidohydrolase (COG3618) from burkholderia multivorans (TARGET EFI-500235) with bound ZN, space group P3221 2012-02-06 2012-02-29 Vetting, M.W.,Toro, R.,Bhosle, R.,Seidel, R.D.,Hillerich, B.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Al Obaidi, N.F.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of an amidohydrolase (COG3618) from burkholderia multivorans (target efi-500235) with bound ZN, space group P3221 to be published 0 0 0 0 4DLM Crystal structure of an amidohydrolase (COG3618) from burkholderia multivorans (TARGET EFI-500235) with bound ZN, space group P212121 2012-02-06 2012-02-29 Vetting, M.W.,Toro, R.,Bhosle, R.,Seidel, R.D.,Hillerich, B.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Al Obaidi, N.F.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of an amidohydrolase (COG3618) from burkholderia multivorans (TARGET EFI-500235) with bound ZN, space group P212121 to be published 0 0 0 0 4DNM Crystal structure of an amidohydrolase (cog3618) from burkholderia multivorans (target efi-500235) with bound hepes, space group p3221 2012-02-08 2012-02-29 Vetting, M.W.,Toro, R.,Bhosle, R.,Seidel, R.D.,Hillerich, B.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Al Obaidi, N.F.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of an amidohydrolase (cog3618) from burkholderia multivorans (target efi-500235) with bound hepes, space group p3221 to be published 0 0 0 0 4DPO Crystal structure of a conserved protein MM_1583 from Methanosarcina mazei Go1 2012-02-13 2012-02-29 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a conserved protein MM_1583 from Methanosarcina mazei Go1 To be Published 0 0 0 0 4DUP Crystal Structure of a quinone oxidoreductase from Rhizobium etli CFN 42 2012-02-22 2012-03-07 Kumaran, D.,Rice, S.,Almo, S.C.,Swaminathan, S. Crystal Structure of a quinone oxidoreductase from Rhizobium etli CFN 42 To be Published 0 0 0 0 3REO Monolignol O-methyltransferase (MOMT) 2011-04-04 2012-03-14 Bhuiya, M.W.,Liu, C.J. Monolignol O-methyltransferase (MOMT) To be Published 0 0 0 0 3RPU 21855551 Crystal structure of the MukE-MukF complex 2011-04-27 2012-03-14 Gloyd, M.,Ghirlando, R.,Guarne, A. The role of MukE in assembling a functional MukBEF complex. J.Mol.Biol. 2011 412 578 590 4DAL Crystal structure of Putative aldehyde dehydrogenase from Sinorhizobium meliloti 1021 2012-01-12 2012-03-14 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. Crystal structure of Putative aldehyde dehydrogenase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 4DWD Crystal structure of mandelate racemase/muconate lactonizing protein from Paracoccus denitrificans PD1222 complexed with magnesium 2012-02-24 2012-03-14 Malashkevich, V.N.,Toro, R.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of mandelate racemase/muconate lactonizing protein from Paracoccus denitrificans PD1222 complexed with magnesium To be Published 0 0 0 0 4DYV Crystal structure of a short-chain dehydrogenase/reductase SDR from Xanthobacter autotrophicus Py2 2012-02-29 2012-03-14 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of a short-chain dehydrogenase/reductase SDR from Xanthobacter autotrophicus Py2 To be Published 0 0 0 0 3UZX 22437839 Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and epiandrosterone 2011-12-07 2012-03-21 Chen, M.,Drury, J.E.,Christianson, D.W.,Penning, T.M. Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING. J.Biol.Chem. 2012 287 16609 16622 4DB5 Crystal structure of Rabbit GITRL 2012-01-13 2012-03-21 Kumar, P.R.,Bhosle, R.,Gizzi, A.,Scott Glenn, A.,Chowhury, S.,Hillerich, B.,Seidel, R.,Nathenson, S.G.,Almo, S.C. Crystal structure of GITRL from Oryctolagus cuniculus to be published 0 0 0 0 4DIO The crystal structure of transhydrogenase from Sinorhizobium meliloti 2012-01-31 2012-03-21 Zhang, Z.,Almo, S.C.,Swaminathan, S. The crystal structure of transhydrogenase from Sinorhizobium meliloti To be Published 0 0 0 0 4DNA CRYSTAL STRUCTURE OF putative glutathione reductase from Sinorhizobium meliloti 1021 2012-02-08 2012-03-21 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. CRYSTAL STRUCTURE OF putative glutathione reductase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 4DU5 Crystal structure of PfkB protein from Polaromonas sp. JS666 2012-02-21 2012-03-21 Agarwal, R.,Almo, S.C.,Swaminathan, S. Crystal structure of PfkB protein from Polaromonas sp. JS666 To be Published 0 0 0 0 4DZ1 22418438 Crystal structure of DalS, an ATP binding cassette transporter for D-alanine from Salmonella enterica 2012-02-29 2012-03-21 Osborne, S.E.,Tuinema, B.R.,Mok, M.C.,Lau, P.S.,Bui, N.K.,Tomljenovic-Berube, A.M.,Vollmer, W.,Zhang, K.,Junop, M.,Coombes, B.K. Characterization of DalS, an ATP-binding Cassette Transporter for D-Alanine, and Its Role in Pathogenesis in Salmonella enterica. J.Biol.Chem. 2012 287 15242 15250 4DZI Crystal structure of amidohydrolase map2389c (target EFI-500390) from Mycobacterium avium subsp. paratuberculosis K-10 2012-03-01 2012-03-21 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C. Crystal structure of amidohydrolase map2389c (target EFI-500390) from Mycobacterium avium To be Published 0 0 0 0 4E38 Crystal structure of probable keto-hydroxyglutarate-aldolase from Vibrionales bacterium SWAT-3 (Target EFI-502156) 2012-03-09 2012-03-21 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of probable keto-hydroxyglutarate-aldolase from Vibrionales bacterium SWAT-3 (Target EFI-502156) To be Published 0 0 0 0 4E3A CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 2012-03-09 2012-03-21 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 To be Published 0 0 0 0 4E3E CRYSTAL STRUCTURE OF putative MaoC domain protein dehydratase from Chloroflexus aurantiacus J-10-fl 2012-03-09 2012-03-21 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. CRYSTAL STRUCTURE OF putative MaoC domain protein dehydratase from Chloroflexus aurantiacus J-10-fl To be Published 0 0 0 0 4E3Z Crystal Structure of a oxidoreductase from Rhizobium etli CFN 42 2012-03-11 2012-03-21 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal Structure of a oxidoreductase from Rhizobium etli CFN 42 To be Published 0 0 0 0 4E4S Crystal structure of Pika GITRL 2012-03-13 2012-03-21 Kumar, P.R.,Bhosle, R.,Bonanno, J.,Chowdhury, S.,Gizzi, A.,Glen, S.,Hillerich, B.,Hammonds, J.,Seidel, R.,Toro, R.,Nathenson, S.G.,Almo, S.C. Crystal structure of GITRL from Ochotona princeps to be published 0 0 0 0 4DBU 22507964 Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid 2012-01-16 2012-03-28 Chen, M.,Adeniji, A.O.,Twenter, B.M.,Winkler, J.D.,Christianson, D.W.,Penning, T.M. Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorg.Med.Chem.Lett. 2012 22 3492 3497 4DNH Crystal structure of hypothetical protein SMc04132 from Sinorhizobium meliloti 1021 2012-02-08 2012-03-28 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. Crystal structure of hypothetical protein SMc04132 from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 4E4F Crystal structure of enolase PC1_0802 (TARGET EFI-502240) from Pectobacterium carotovorum subsp. carotovorum PC1 2012-03-12 2012-03-28 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of ENOLASE PC1_0802 from Pectobacterium carotovorum To be Published 0 0 0 0 4E4G Crystal structure of putative Methylmalonate-semialdehyde dehydrogenase from Sinorhizobium meliloti 1021 2012-03-12 2012-03-28 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of putative Methylmalonate-semialdehyde dehydrogenase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 4E5T Crystal structure of a putative Mandelate racemase/Muconate lactonizing enzyme (Target PSI-200750) from Labrenzia alexandrii DFL-11 2012-03-14 2012-03-28 Kumar, P.R.,Bonanno, J.,Chowdhury, S.,Foti, R.,Gizzi, A.,Glen, S.,Hammonds, J.,Hillerich, B.,Matikainen, B.,Seidel, R.,Toro, R.,Zencheck, W.,Almo, S.C. Crystal structure of a putative MR/ML enzyme from Labrenzia alexandrii DFL-11 to be published 0 0 0 0 4E6M Crystal structure of Putative dehydratase protein from Salmonella enterica subsp. enterica serovar Typhimurium (Salmonella typhimurium) 2012-03-15 2012-04-04 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of Putative dehydratase protein from Salmonella enterica subsp. enterica serovar Typhimurium (Salmonella typhimurium) To be Published 0 0 0 0 3V1V 22455514 Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and geranyl-S-thiolodiphosphate 2011-12-10 2012-04-11 Koksal, M.,Chou, W.K.,Cane, D.E.,Christianson, D.W. Structure of 2-Methylisoborneol Synthase from Streptomyces coelicolor and Implications for the Cyclization of a Noncanonical C-Methylated Monoterpenoid Substrate. Biochemistry 2012 51 3011 3020 3V1X 22455514 Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and 2-fluorogeranyl diphosphate 2011-12-10 2012-04-11 Koksal, M.,Chou, W.K.,Cane, D.E.,Christianson, D.W. Structure of 2-Methylisoborneol Synthase from Streptomyces coelicolor and Implications for the Cyclization of a Noncanonical C-Methylated Monoterpenoid Substrate. Biochemistry 2012 51 3011 3020 3VC1 22455498 Crystal structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor A3(2) in complex with Mg2+, geranyl-S-thiolodiphosphate, and S-adenosyl-L-homocysteine 2012-01-03 2012-04-11 Koksal, M.,Chou, W.K.,Cane, D.E.,Christianson, D.W. Structure of Geranyl Diphosphate C-Methyltransferase from Streptomyces coelicolor and Implications for the Mechanism of Isoprenoid Modification. Biochemistry 2012 51 3003 3010 3VC2 22455498 Crystal structure of geranyl diphosphate C-methyltransferase from Streptomyces coelicolor A3(2) in complex with Mg2+, geranyl diphosphate, and S-adenosyl-L-homocysteine 2012-01-03 2012-04-11 Koksal, M.,Chou, W.K.,Cane, D.E.,Christianson, D.W. Structure of Geranyl Diphosphate C-Methyltransferase from Streptomyces coelicolor and Implications for the Mechanism of Isoprenoid Modification. Biochemistry 2012 51 3003 3010 4E98 25945704 Crystal structure of possible CutA1 divalent ion tolerance protein from Cryptosporidium parvum Iowa II 2012-03-20 2012-04-11 Buchko, G.W.,Abendroth, J.,Clifton, M.C.,Robinson, H.,Zhang, Y.,Hewitt, S.N.,Staker, B.L.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J. Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis. Acta Crystallogr F Struct Biol 2015 71 522 530 3U73 22285761 Crystal structure of stabilized human uPAR mutant in complex with ATF 2011-10-13 2012-04-18 Xu, X.,Gardsvoll, H.,Yuan, C.,Lin, L.,Ploug, M.,Huang, M. Crystal structure of the urokinase receptor in a ligand-free form. J.Mol.Biol. 2012 416 629 641 3U74 22285761 Crystal structure of stabilized human uPAR mutant 2011-10-13 2012-04-18 Xu, X.,Gardsvoll, H.,Yuan, C.,Lin, L.,Ploug, M.,Huang, M. Crystal structure of the urokinase receptor in a ligand-free form. J.Mol.Biol. 2012 416 629 641 3ULY 22484091 Crystal Structure of BROX Bro1 Domain in Complex with the C-Terminal Tails of CHMP5 2011-11-11 2012-04-18 Mu, R.,Dussupt, V.,Jiang, J.,Sette, P.,Rudd, V.,Chuenchor, W.,Bello, N.F.,Bouamr, F.,Xiao, T.S. Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B. Structure 2012 20 887 898 3UM0 22484091 Crystal structure of the Brox Bro1 domain in complex with the C-terminal tail of CHMP5 2011-11-11 2012-04-18 Mu, R.,Dussupt, V.,Jiang, J.,Sette, P.,Rudd, V.,Chuenchor, W.,Bello, N.F.,Bouamr, F.,Xiao, T.S. Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B. Structure 2012 20 887 898 3UM1 22484091 Crystal structure of the Brox Bro1 domain in complex with the C-terminal tail of CHMP5 2011-11-11 2012-04-18 Mu, R.,Dussupt, V.,Jiang, J.,Sette, P.,Rudd, V.,Chuenchor, W.,Bello, N.F.,Bouamr, F.,Xiao, T.S. Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B. Structure 2012 20 887 898 3UM2 22484091 Crystal structure of the Brox Bro1 domain in complex with the C-terminal tail of CHMP5 2011-11-12 2012-04-18 Mu, R.,Dussupt, V.,Jiang, J.,Sette, P.,Rudd, V.,Chuenchor, W.,Bello, N.F.,Bouamr, F.,Xiao, T.S. Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B. Structure 2012 20 887 898 3UM3 22484091 Crystal structure of the Brox Bro1 domain in complex with the C-terminal tail of CHMP4B 2011-11-12 2012-04-18 Mu, R.,Dussupt, V.,Jiang, J.,Sette, P.,Rudd, V.,Chuenchor, W.,Bello, N.F.,Bouamr, F.,Xiao, T.S. Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B. Structure 2012 20 887 898 4E4U Crystal structure of a putative Mandelate racemase/Muconate lactonizing enzyme (Target PSI-200780) from Burkholderia SAR-1 2012-03-13 2012-04-18 Kumar, P.R.,Bonanno, J.,Chowdhury, S.,Foti, R.,Gizzi, A.,Hammonds, J.,Hillerich, B.,Matikainen, B.,Seidel, R.,Toro, R.,Zencheck, W.,Almo, S.C. Crystal structure of a putative MR/ML enzyme from Burkholderia SAR-1 to be published 0 0 0 0 4ECI Crystal structure of glutathione s-transferase prk13972 (target efi-501853) from pseudomonas aeruginosa pacs2 complexed with acetate 2012-03-26 2012-04-18 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glutathione S-Transferase Prk13972 from Pseudomonas Aeruginosa To be Published 0 0 0 0 4ECJ Crystal structure of glutathione s-transferase prk13972 (target efi-501853) from pseudomonas aeruginosa pacs2 complexed with glutathione 2012-03-26 2012-04-18 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glutathione S-Transferase Prk13972 from Pseudomonas Aeruginosa To be Published 0 0 0 0 4EEK Crystal structure of HAD FAMILY HYDROLASE DR_1622 from Deinococcus radiodurans R1 (TARGET EFI-501256) With bound phosphate and sodium 2012-03-28 2012-04-18 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of HAD HYDROLASE DR_1622 Deinococcus radiodurans R1 (TARGET EFI-501256) To be Published 0 0 0 0 4EEL Crystal structure of HAD FAMILY HYDROLASE DR_1622 from Deinococcus radiodurans R1 (TARGET EFI-501256) with bound citrate and sodium 2012-03-28 2012-04-18 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of HAD HYDROLASE DR_1622 Deinococcus radiodurans R1 (TARGET EFI-501256) To be Published 0 0 0 0 4EEN crystal structure of HAD FAMILY HYDROLASE DR_1622 from Deinococcus radiodurans R1 (TARGET EFI-501256) with bound magnesium 2012-03-28 2012-04-18 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of HAD HYDROLASE DR_1622 Deinococcus radiodurans R1 (TARGET EFI-501256) To be Published 0 0 0 0 3UX1 22496238 Structural Characterization of Adeno-Associated Virus Serotype 9 2011-12-03 2012-05-02 Dimattia, M.A.,Nam, H.J.,Van Vliet, K.,Mitchell, M.,Bennett, A.,Gurda, B.L.,McKenna, R.,Olson, N.H.,Sinkovits, R.S.,Potter, M.,Byrne, B.J.,Aslanidi, G.,Zolotukhin, S.,Muzyczka, N.,Baker, T.S.,Agbandje-McKenna, M. Structural insight into the unique properties of adeno-associated virus serotype 9. J.Virol. 2012 86 6947 6958 4DGW 22314233 Crystal Structure of the SF3a splicing factor complex of U2 snRNP 2012-01-26 2012-05-02 Lin, P.C.,Xu, R.M. Structure and assembly of the SF3a splicing factor complex of U2 snRNP Embo J. 2012 31 1579 1590 4DGW 22314233 Crystal Structure of the SF3a splicing factor complex of U2 snRNP 2012-01-26 2012-05-02 Lin, P.C.,Xu, R.M. Structure and assembly of the SF3a splicing factor complex of U2 snRNP Embo J. 2012 31 1579 1590 4E6H 22513198 CRYSTAL STRUCTURE OF THE HAT domain of k. lactis RNA14 2012-03-15 2012-05-02 Paulson, A.R.,Tong, L. Crystal structure of the Rna14-Rna15 complex. Rna 2012 18 1154 1162 4E6S 22505416 Crystal structure of the SCAN domain from mouse Zfp206 2012-03-15 2012-05-02 Liang, Y.,Choo, S.H.,Rossbach, M.,Baburajendran, N.,Palasingam, P.,Kolatkar, P.R. Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206. Acta Crystallogr.,Sect.F 2012 68 443 447 4E6S 22505416 Crystal structure of the SCAN domain from mouse Zfp206 2012-03-15 2012-05-02 Liang, Y.,Choo, S.H.,Rossbach, M.,Baburajendran, N.,Palasingam, P.,Kolatkar, P.R. Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206. Acta Crystallogr.,Sect.F 2012 68 443 447 4E85 22513198 crystal STRUCTURE OF HAT DOMAIN OF RNA14 2012-03-19 2012-05-02 Paulson, A.R.,Tong, L. Crystal structure of the Rna14-Rna15 complex. Rna 2012 18 1154 1162 4EBA 22513198 Crystal structure of the Rna14-Rna15 complex 2012-03-23 2012-05-02 Paulson, A.R.,Tong, L. Crystal structure of the Rna14-Rna15 complex. Rna 2012 18 1154 1162 4EJ6 Crystal structure of a putative zinc-binding dehydrogenase (Target PSI-012003) from Sinorhizobium meliloti 1021 2012-04-06 2012-05-02 Sampathkumar, P.,Banu, N.,Bhosle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Fiser, A.,Gizzi, A.,Glenn, A.S.,Hammonds, J.,Hillerich, B.,Khafizov, K.,Love, J.D.,Matikainen, B.,Patskovsky, Y.,Seidel, R.,Toro, R.,Zencheck, W.,Almo, S.C. Crystal structure of a putative zinc-binding dehydrogenase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 4ESK Crystal structure of a strand-swapped dimer of Mouse Leukocyte-associated immunoglobulin-like receptor 1 (NYSGRC-006047)IG-like domain 2012-04-23 2012-05-02 Sampathkumar, P.,Bonanno, J.,Fiser, A.,Patskovsky, Y.,Zencheck, W.,Nathenson, S.G.,Almo, S.C. Crystal structure of a strand-swapped dimer of Mouse Leukocyte-associated immunoglobulin-like receptor 1 IG-like domain to be published 0 0 0 0 4EN0 25087510 Crystal structure of light 2012-04-12 2012-05-09 Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C. Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure 2014 22 1252 1262 3RRQ Crystal structure of the extracellular domain of human PD-1 2011-04-29 2012-05-16 Lazar-Molnar, E.,Ramagopal, U.A.,Nathenson, S.G.,Almo, S.C. Crystal structure of the extracellular domain of human PD-1 To be Published 0 0 0 0 4ESO Crystal structure of a putative oxidoreductase protein from Sinorhizobium meliloti 1021 in complex with NADP 2012-04-23 2012-05-16 Ghosh, A.,Bhoshle, R.,Toro, R.,Gizzi, A.,Hillerich, B.,Seidel, R.,Almo, S.C. Crystal structure of a putative oxidoreductase protein from Sinorhizobium meliloti 1021 in complex with NADP To be Published 0 0 0 0 4DMZ 22605337 PelD 156-455 from Pseudomonas aeruginosa PA14, apo form 2012-02-08 2012-05-23 Whitney, J.C.,Colvin, K.M.,Marmont, L.S.,Robinson, H.,Parsek, M.R.,Howell, P.L. Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa. J.Biol.Chem. 2012 287 23582 23593 4DN0 22605337 PelD 156-455 from Pseudomonas aeruginosa PA14 in complex with c-di-GMP 2012-02-08 2012-05-23 Whitney, J.C.,Colvin, K.M.,Marmont, L.S.,Robinson, H.,Parsek, M.R.,Howell, P.L. Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa. J.Biol.Chem. 2012 287 23582 23593 4EJN 22533986 Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide 2012-04-06 2012-05-23 Ashwell, M.A.,Lapierre, J.M.,Brassard, C.,Bresciano, K.,Bull, C.,Cornell-Kennon, S.,Eathiraj, S.,France, D.S.,Hall, T.,Hill, J.,Kelleher, E.,Khanapurkar, S.,Kizer, D.,Koerner, S.,Link, J.,Liu, Y.,Makhija, S.,Moussa, M.,Namdev, N.,Nguyen, K.,Nicewonger, R.,Palma, R.,Szwaya, J.,Tandon, M.,Uppalapati, U.,Vensel, D.,Volak, L.P.,Volckova, E.,Westlund, N.,Wu, H.,Yang, R.Y.,Chan, T.C. Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. J.Med.Chem. 2012 55 5291 5310 4EXJ Crystal structure of glutathione s-transferase like protein lelg_03239 (target efi-501752) from lodderomyces elongisporus 2012-04-30 2012-05-23 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal structure of glutathione s-transferase like protein lelg_03239 (target efi-501752) from lodderomyces elongisporus To be Published 0 0 0 0 4EZB CRYSTAL STRUCTURE OF the Conserved hypothetical protein from Sinorhizobium meliloti 1021 2012-05-02 2012-05-23 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. CRYSTAL STRUCTURE OF the Conserved hypothetical protein from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 3S2Y 22879982 Crystal structure of a chromate/uranium reductase from Gluconacetobacter hansenii 2011-05-17 2012-05-30 Jin, H.,Zhang, Y.,Buchko, G.W.,Varnum, S.M.,Robinson, H.,Squier, T.C.,Long, P.E. Structure Determination and Functional Analysis of a Chromate Reductase from Gluconacetobacter hansenii. Plos One 2012 7 0 0 3SJQ 22579256 Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin 2011-06-21 2012-05-30 Zhang, M.,Abrams, C.,Wang, L.,Gizzi, A.,He, L.,Lin, R.,Chen, Y.,Loll, P.J.,Pascal, J.M.,Zhang, J.F. Structural basis for calmodulin as a dynamic calcium sensor. Structure 2012 20 911 923 4DQY 22582261 Structure of Human PARP-1 bound to a DNA double strand break 2012-02-16 2012-05-30 Langelier, M.F.,Planck, J.L.,Roy, S.,Pascal, J.M. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science 2012 336 728 732 4F2D Crystal Structure of Escherichia coli L-arabinose Isomerase (ECAI) complexed with Ribitol 2012-05-07 2012-05-30 Manjasetty, B.A.,Burley, S.K.,Almo, S.C.,Chance, M.R. Crystal Structure of Escherichia coli L-arabinose Isomerase (ECAI) complexed with Ribitol TO BE PUBLISHED 0 0 0 0 4F3T 22682761 Human Argonaute-2 - miR-20a complex 2012-05-09 2012-05-30 Elkayam, E.,Kuhn, C.D.,Tocilj, A.,Haase, A.D.,Greene, E.M.,Hannon, G.J.,Joshua-Tor, L. The Structure of Human Argonaute-2 in Complex with miR-20a. Cell(Cambridge,Mass.) 2012 150 100 110 4F3X Crystal structure of putative aldehyde dehydrogenase from Sinorhizobium meliloti 1021 complexed with NAD 2012-05-09 2012-05-30 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of putative aldehyde dehydrogenase from Sinorhizobium meliloti 1021 complexed with NAD To be Published 0 0 0 0 3SA3 Crystal structure of wild-type HIV-1 protease in complex with AG23 2011-06-02 2012-06-06 Altman, M.D.,Nalam, M.N.L.,Ali, A.,Cao, H.,Rana, T.M.,Schiffer, C.A.,Tidor, B. Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published 0 0 0 0 3SAC Crystal structure of wild-type HIV-1 protease in complex with AF80 2011-06-02 2012-06-06 Altman, M.D.,Nalam, M.N.L.,Ali, A.,Cao, H.,Rana, T.M.,Schiffer, C.A.,Tidor, B. Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published 0 0 0 0 4DOJ 22940865 Crystal structure of BetP in outward-facing conformation 2012-02-09 2012-06-06 Perez, C.,Koshy, C.,Yildiz, O.,Ziegler, C. Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP. Nature 2012 490 126 130 4EP3 22549928 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate CA-p2 2012-04-16 2012-06-06 Alvizo, O.,Mittal, S.,Mayo, S.L.,Schiffer, C.A. Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci. 2012 21 1029 1041 4EPJ 22549928 Crystal Structure of inactive single chain wild-type HIV-1 Protease in Complex with the substrate p2-NC 2012-04-17 2012-06-06 Alvizo, O.,Mittal, S.,Mayo, S.L.,Schiffer, C.A. Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci. 2012 21 1029 1041 4EQ0 22549928 Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC 2012-04-17 2012-06-06 Alvizo, O.,Mittal, S.,Mayo, S.L.,Schiffer, C.A. Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci. 2012 21 1029 1041 4F0R Crystal structure of an adenosine deaminase homolog from Chromobacterium violaceum (target NYSGRC-019589) bound Zn and 5'-Methylthioadenosine (unproductive complex) 2012-05-04 2012-06-06 Kim, J.,Vetting, M.W.,Sauder, J.M.,Burley, S.K.,Raushel, F.M.,Bonanno, J.B.,Almo, S.C. Crystal structure of an adenosine deaminase homolog from Chromobacterium violaceum (target NYSGRC-019589) bound Zn and 5'-Methylthioadenosine (unproductive complex) To be Published 0 0 0 0 4F0S Crystal structure of an adenosine deaminase homolog from Chromobacterium violaceum (target NYSGRC-019589) with bound inosine. 2012-05-04 2012-06-06 Kim, J.,Vetting, M.W.,Sauder, J.M.,Burley, S.K.,Raushel, F.M.,Bonanno, J.B.,Almo, S.C. Crystal structure of an adenosine deaminase homolog from Chromobacterium violaceum (target NYSGRC-019589) with bound inosine. To be Published 0 0 0 0 3S9U Bacillus anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP120J 2011-06-02 2012-06-13 Anderson, A.C.,Beierlein, J.M.,Viswanathan, K.,Wright, D.L. Structure-Activity Studies of Heterocyclic Propargyl-linked TMP Analogs Targeting Bacillus anthracis Dihydrofolate Reductase To be Published 0 0 0 0 3UBB 22515733 The crystal structure of GlpG in complex with a phosphonofluoridate inhibitor 2011-10-24 2012-06-13 Xue, Y.,Chowdhury, S.,Liu, X.,Akiyama, Y.,Ellman, J.,Ha, Y. Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S' Subsites. Biochemistry 2012 51 3723 3731 4F62 23493556 Crystal structure of a putative farnesyl-diphosphate synthase from Marinomonas sp. MED121 (Target EFI-501980) 2012-05-14 2012-06-13 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 4FFU CRYSTAL STRUCTURE OF putative MaoC-like (monoamine oxidase-like) protein, similar to NodN from Sinorhizo Bium meliloti 1021 2012-06-01 2012-06-13 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. CRYSTAL STRUCTURE OF putative MaoC-like (monoamine oxidase-like) protein, similar to NodN from Sinorhizo Bium meliloti 1021 To be Published 0 0 0 0 4EV0 Crystal Structure of Thermus thermophilus Catabolite Activator Protein 2012-04-25 2012-06-20 Hudson, B.P.,Turo, K.,Birktoft, J.J.,Ebright, R.H.,Lawson, C.L. Crystal Structure of T. thermophilius Catabolite Activator Protein To be Published 0 0 0 0 4F71 Crystal structure of had family enzyme bt-2542 (target efi-501088) from Bacteroides thetaiotaomicron, wild-type protein, complex with magnesium and inorganic phosphate 2012-05-15 2012-06-20 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Almo, S.C.,Gerlt, J.A. Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088) To be Published 0 0 0 0 4F72 Crystal structure of had family enzyme bt-2542 (target efi-501088) from Bacteroides thetaiotaomicron, asp12ala mutant, complex with magnesium and inorganic phosphate 2012-05-15 2012-06-20 Patskovsky, Y.,Farelli, J.D.,Toro, R.,Bhosle, R.,Hillerich, B.,Washington, E.,Seidel, R.D.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Almo, S.C.,Gerlt, J.A. Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088) To be Published 0 0 0 0 4FCI 22869115 Crystal Structure of the Mn2+2-Human Arginase I-AGPA Complex 2012-05-25 2012-06-20 D'Antonio, E.L.,Christianson, D.W. Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I. Acta Crystallogr.,Sect.F 2012 68 889 893 4FCK 22869115 Crystal Structure of the Co2+2-Human Arginase I-AGPA Complex 2012-05-25 2012-06-20 D'Antonio, E.L.,Christianson, D.W. Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I. Acta Crystallogr.,Sect.F 2012 68 889 893 4E11 22690733 Crystal structure of kynurenine formamidase from Drosophila melanogaster 2012-03-05 2012-06-27 Han, Q.,Robinson, H.,Li, J. Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem.J. 2012 446 253 260 4E14 22690733 Crystal structure of kynurenine formamidase conjugated with phenylmethylsulfonyl fluoride 2012-03-05 2012-06-27 Han, Q.,Robinson, H.,Li, J. Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem.J. 2012 446 253 260 4E15 22690733 Crystal structure of kynurenine formamidase conjugated with an inhibitor 2012-03-05 2012-06-27 Han, Q.,Robinson, H.,Li, J. Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Biochem.J. 2012 446 253 260 4EZC 22733730 Crystal Structure of the UT-B Urea Transporter from Bos Taurus 2012-05-02 2012-06-27 Levin, E.J.,Cao, Y.,Enkavi, G.,Quick, M.,Pan, Y.,Tajkhorshid, E.,Zhou, M. Structure and permeation mechanism of a mammalian urea transporter. Proc.Natl.Acad.Sci.USA 2012 109 11194 11199 4EZD 22733730 Crystal Structure of the UT-B Urea Transporter from Bos Taurus Bound to Selenourea 2012-05-02 2012-06-27 Levin, E.J.,Cao, Y.,Enkavi, G.,Quick, M.,Pan, Y.,Tajkhorshid, E.,Zhou, M. Structure and permeation mechanism of a mammalian urea transporter. Proc.Natl.Acad.Sci.USA 2012 109 11194 11199 4F3Q 26033498 Structure of a YebC family protein (CBU_1566) from Coxiella burnetii 2012-05-09 2012-06-27 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 4FD4 22753468 Crystal structure of mosquito arylalkylamine N-Acetyltransferase like 5b 2012-05-26 2012-06-27 Han, Q.,Robinson, H.,Ding, H.,Christensen, B.M.,Li, J. Evolution of insect arylalkylamine N-acetyltransferases: structural evidence from the yellow fever mosquito, Aedes aegypti. Proc.Natl.Acad.Sci.USA 2012 109 11669 11674 4FD5 22753468 Crystal structure of arylalkylamine N-Acetyltransferase 2 from Aedes aegypti 2012-05-26 2012-06-27 Han, Q.,Robinson, H.,Ding, H.,Christensen, B.M.,Li, J. Evolution of insect arylalkylamine N-acetyltransferases: structural evidence from the yellow fever mosquito, Aedes aegypti. Proc.Natl.Acad.Sci.USA 2012 109 11669 11674 4FD6 22753468 Crystal structure of native arylalkylamine N-Acetyltransferase 2 from the yellow fever mosquito, Aedes aegypti 2012-05-26 2012-06-27 Han, Q.,Robinson, H.,Ding, H.,Christensen, B.M.,Li, J. Evolution of insect arylalkylamine N-acetyltransferases: structural evidence from the yellow fever mosquito, Aedes aegypti. Proc.Natl.Acad.Sci.USA 2012 109 11669 11674 4FD7 22753468 Crystal structure of insect putative arylalkylamine N-Acetyltransferase 7 from the yellow fever mosquito Aedes aegypt 2012-05-26 2012-06-27 Han, Q.,Robinson, H.,Ding, H.,Christensen, B.M.,Li, J. Evolution of insect arylalkylamine N-acetyltransferases: structural evidence from the yellow fever mosquito, Aedes aegypti. Proc.Natl.Acad.Sci.USA 2012 109 11669 11674 4FI4 Crystal structure of mannonate dehydratase PRK15072 (TARGET EFI-502214) from Caulobacter sp. K31 2012-06-07 2012-06-27 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Enolase Prk15072 (Target Efi-502214) from Caulobacter Sp. K31 To be Published 0 0 0 0 4F3R 26033498 Structure of phosphopantetheine adenylyltransferase (CBU_0288) from Coxiella burnetii 2012-05-09 2012-07-04 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 4F04 22667327 A Second Allosteric site in E. coli Aspartate Transcarbamoylase: R-state ATCase with UTP bound 2012-05-03 2012-07-11 Peterson, A.W.,Cockrell, G.M.,Kantrowitz, E.R. A second allosteric site in Escherichia coli aspartate transcarbamoylase. Biochemistry 2012 51 4776 4778 4F55 22730118 Crystal Structure of the Catalytic Domain of the Bacillus cereus SleB Protein 2012-05-11 2012-07-11 Li, Y.,Jin, K.,Setlow, B.,Setlow, P.,Hao, B. Crystal Structure of the Catalytic Domain of the Bacillus cereus SleB Protein, Important in Cortex Peptidoglycan Degradation during Spore Germination. J.Bacteriol. 2012 194 4537 4545 4FP4 23493556 Crystal structure of isoprenoid synthase a3mx09 (target efi-501993) from pyrobaculum calidifontis 2012-06-21 2012-07-11 Wallrapp, F.H.,Pan, J.J.,Ramamoorthy, G.,Almonacid, D.E.,Hillerich, B.S.,Seidel, R.,Patskovsky, Y.,Babbitt, P.C.,Almo, S.C.,Jacobson, M.P.,Poulter, C.D. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA 2013 110 0 0 4DF6 22587688 Crystal Structure of the inhibitor NXL104 Covalent Adduct with TB B-lactamase 2012-01-23 2012-07-18 Xu, H.,Hazra, S.,Blanchard, J.S. NXL104 irreversibly inhibits the {beta}-lactamase from Mycobacterium tuberculosis. Biochemistry 2012 51 4551 4557 4FHQ 26202493 Crystal Structure of HVEM 2012-06-06 2012-07-18 Liu, W.,Vigdorovich, V.,Zhan, C.,Patskovsky, Y.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C. Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM. Mol Biotechnol 2015 57 914 922 4FWY 22539151 F33Y CuB myoglobin (F33Y L29H F43H sperm whale myoglobin) with copper bound 2012-07-02 2012-07-18 Miner, K.D.,Mukherjee, A.,Gao, Y.G.,Null, E.L.,Petrik, I.D.,Zhao, X.,Yeung, N.,Robinson, H.,Lu, Y. A Designed Functional Metalloenzyme that Reduces O(2) to H(2) O with Over One Thousand Turnovers. Angew.Chem.Int.Ed.Engl. 2012 51 5589 5592 4FWY 22539151 F33Y CuB myoglobin (F33Y L29H F43H sperm whale myoglobin) with copper bound 2012-07-02 2012-07-18 Miner, K.D.,Mukherjee, A.,Gao, Y.G.,Null, E.L.,Petrik, I.D.,Zhao, X.,Yeung, N.,Robinson, H.,Lu, Y. A Designed Functional Metalloenzyme that Reduces O(2) to H(2) O with Over One Thousand Turnovers. Angew.Chem.Int.Ed.Engl. 2012 51 5589 5592 4FWY 22539151 F33Y CuB myoglobin (F33Y L29H F43H sperm whale myoglobin) with copper bound 2012-07-02 2012-07-18 Miner, K.D.,Mukherjee, A.,Gao, Y.G.,Null, E.L.,Petrik, I.D.,Zhao, X.,Yeung, N.,Robinson, H.,Lu, Y. A Designed Functional Metalloenzyme that Reduces O(2) to H(2) O with Over One Thousand Turnovers. Angew.Chem.Int.Ed.Engl. 2012 51 5589 5592 3TWK 22789755 Crystal structure of arabidopsis thaliana FPG 2011-09-22 2012-07-25 Duclos, S.,Aller, P.,Jaruga, P.,Dizdaroglu, M.,Wallace, S.S.,Doublie, S. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. Dna Repair 2012 11 714 725 3TWK 22789755 Crystal structure of arabidopsis thaliana FPG 2011-09-22 2012-07-25 Duclos, S.,Aller, P.,Jaruga, P.,Dizdaroglu, M.,Wallace, S.S.,Doublie, S. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. Dna Repair 2012 11 714 725 3TWK 22789755 Crystal structure of arabidopsis thaliana FPG 2011-09-22 2012-07-25 Duclos, S.,Aller, P.,Jaruga, P.,Dizdaroglu, M.,Wallace, S.S.,Doublie, S. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. Dna Repair 2012 11 714 725 3U3Z 22908299 Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142 2011-10-06 2012-07-25 Singh, N.,Basnet, H.,Wiltshire, T.D.,Mohammad, D.H.,Thompson, J.R.,Heroux, A.,Botuyan, M.V.,Yaffe, M.B.,Couch, F.J.,Rosenfeld, M.G.,Mer, G. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proc.Natl.Acad.Sci.USA 2012 109 14381 14386 3UO1 22753930 Structure of a monoclonal antibody complexed with its MHC-I antigen 2011-11-16 2012-07-25 Mage, M.G.,Dolan, M.A.,Wang, R.,Boyd, L.F.,Revilleza, M.J.,Robinson, H.,Natarajan, K.,Myers, N.B.,Hansen, T.H.,Margulies, D.H. The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J.Immunol. 2012 189 1391 1399 3UYR 22753930 Structure of a monoclonal antibody complexed with its MHC-I antigen 2011-12-06 2012-07-25 Mage, M.G.,Dolan, M.A.,Wang, R.,Boyd, L.F.,Revilleza, M.J.,Robinson, H.,Natarajan, K.,Myers, N.B.,Hansen, T.H.,Margulies, D.H. The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J.Immunol. 2012 189 1391 1399 3V4U 22753930 Structure of a monoclonal antibody complexed with its MHC-I antigen 2011-12-15 2012-07-25 Mage, M.G.,Dolan, M.A.,Wang, R.,Boyd, L.F.,Revilleza, M.J.,Robinson, H.,Natarajan, K.,Myers, N.B.,Hansen, T.H.,Margulies, D.H. The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J.Immunol. 2012 189 1391 1399 3V52 22753930 Structure of a monoclonal antibody complexed with its MHC-I antigen 2011-12-15 2012-07-25 Mage, M.G.,Dolan, M.A.,Wang, R.,Boyd, L.F.,Revilleza, M.J.,Robinson, H.,Natarajan, K.,Myers, N.B.,Hansen, T.H.,Margulies, D.H. The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J.Immunol. 2012 189 1391 1399 4EZE Crystal structure of had family hydrolase t0658 from Salmonella enterica subsp. enterica serovar Typhi (Target EFI-501419) 2012-05-02 2012-07-25 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Allen, K.N.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of had hydrolase t0658 from Salmonella enterica (Target EFI-501419) To be Published 0 0 0 0 4F9D 22810235 Structure of Escherichia coli PgaB 42-655 in complex with nickel 2012-05-18 2012-07-25 Little, D.J.,Poloczek, J.,Whitney, J.C.,Robinson, H.,Nitz, M.,Howell, P.L. The Structure and Metal Dependent Activity of Escherichia coli PgaB Provides Insight into the Partial De-N-acetylation of Poly-b-1,6-N-acetyl-D-glucosamine J.Biol.Chem. 2012 287 31126 31137 4F9G 22705373 Crystal structure of STING complex with Cyclic di-GMP. 2012-05-18 2012-07-25 Yin, Q.,Tian, Y.,Kabaleeswaran, V.,Jiang, X.,Tu, D.,Eck, M.J.,Chen, Z.J.,Wu, H. Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING. Mol.Cell 2012 46 735 745 4F9J 22810235 Structure of Escherichia coli PgaB 42-655 in complex with iron 2012-05-18 2012-07-25 Little, D.J.,Poloczek, J.,Whitney, J.C.,Robinson, H.,Nitz, M.,Howell, P.L. The Structure and Metal Dependent Activity of Escherichia coli PgaB Provides Insight into the Partial De-N-acetylation of Poly-b-1,6-N-acetyl-D-glucosamine J.Biol.Chem. 2012 287 31126 31137 4FC8 22781759 Crystal structure of transcription regulator protein Rtr1 from Kluyveromyces lactis 2012-05-24 2012-07-25 Xiang, K.,Manley, J.L.,Tong, L. The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat Commun 2012 3 946 946 4FET 22777830 Catalytic domain of germination-specific lytic tansglycosylase SleB from Bacillus anthracis 2012-05-30 2012-07-25 Jing, X.,Robinson, H.R.,Heffron, J.D.,Popham, D.L.,Schubot, F.D. The catalytic domain of the germination-specific lytic transglycosylase SleB from Bacillus anthracis displays a unique active site topology. Proteins 2012 80 2469 2475 4FET 22777830 Catalytic domain of germination-specific lytic tansglycosylase SleB from Bacillus anthracis 2012-05-30 2012-07-25 Jing, X.,Robinson, H.R.,Heffron, J.D.,Popham, D.L.,Schubot, F.D. The catalytic domain of the germination-specific lytic transglycosylase SleB from Bacillus anthracis displays a unique active site topology. Proteins 2012 80 2469 2475 4G2N Crystal structure of putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding from Polaromonas sp. JS6 66 2012-07-12 2012-07-25 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding from Polaromonas sp. JS6 66 To be Published 0 0 0 0 4G4F Crystal structure of GITRL from Bushbaby 2012-07-16 2012-08-01 Kumar, P.R.,Nathenson, S.G.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC),Atoms-to-Animals: The Immune Function Network (IFN) Crystal structure of GITRL from Otolemur garnettii to be published 0 0 0 0 3UCT 22803592 Structure of Mn2+-bound N-terminal domain of calmodulin in the presence of Zn2+ 2011-10-27 2012-08-08 Senguen, F.T.,Grabarek, Z. X-ray Structures of Magnesium and Manganese Complexes with the N-Terminal Domain of Calmodulin: Insights into the Mechanism and Specificity of Metal Ion Binding to an EF-Hand. Biochemistry 2012 51 6182 6194 3UCW 22803592 Structure of MG2+ bound N-Terminal domain of Calmodulin 2011-10-27 2012-08-08 Senguen, F.T.,Grabarek, Z. X-ray Structures of Magnesium and Manganese Complexes with the N-Terminal Domain of Calmodulin: Insights into the Mechanism and Specificity of Metal Ion Binding to an EF-Hand. Biochemistry 2012 51 6182 6194 3UCY 22803592 Structure of Mg2+ bound N-terminal domain of calmodulin in the presence of Zn2+ 2011-10-27 2012-08-08 Senguen, F.T.,Grabarek, Z. X-ray Structures of Magnesium and Manganese Complexes with the N-Terminal Domain of Calmodulin: Insights into the Mechanism and Specificity of Metal Ion Binding to an EF-Hand. Biochemistry 2012 51 6182 6194 4DXB 22720063 2.29A structure of the engineered MBP TEM-1 fusion protein RG13 in complex with zinc, P1 space group 2012-02-27 2012-08-08 Ke, W.,Laurent, A.H.,Armstrong, M.D.,Chen, Y.,Smith, W.E.,Liang, J.,Wright, C.M.,Ostermeier, M.,van den Akker, F. Structure of an Engineered beta-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation. Plos One 2012 7 0 0 4DXC 22720063 Crystal structure of the engineered MBP TEM-1 fusion protein RG13, C2 space group 2012-02-27 2012-08-08 Ke, W.,Laurent, A.H.,Armstrong, M.D.,Chen, Y.,Smith, W.E.,Liang, J.,Wright, C.M.,Ostermeier, M.,van den Akker, F. Structure of an Engineered beta-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation. Plos One 2012 7 0 0 4G8S Crystal Structure Of a Putative Nitroreductase from Geobacter sulfurreducens PCA (Target PSI-013445) 2012-07-23 2012-08-08 Kumar, P.R.,Ahmed, M.,Banu, N.,Bhosle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Gizzi, A.,Glen, S.,Hammonds, J.,Hillerich, B.,Love, J.D.,Seidel, R.,Stead, M.,Toro, R.,Washington, E.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) Crystal structure of a nitroreductase from Geobacter sulfurreducens PCA to be published 0 0 0 0 4FB5 Crystal structure of a probable oxidoreduxtase protein 2012-05-22 2012-08-15 Eswaramoorthy, S.,Chamala, S.,Evans, B.,Foti, R.,Gizzi, A.,Hillerich, B.,Kar, A.,Lafleur, J.,Seidel, R.,Villigas, G.,Zencheck, W.,Almo, S.C.,Swaminathan, S. Crystal structure of a probable oxidoreduxtase protein To be Published 0 0 0 0 4FGS Crystal structure of a probable dehydrogenase protein 2012-06-04 2012-08-15 Eswaramoorthy, S.,Rice, S.,Almo, S.C.,Swaminathan, S. Crystal structure of a probable dehydrogenase protein To be Published 0 0 0 0 4G9Q Crystal structure of a 4-carboxymuconolactone decarboxylase 2012-07-24 2012-08-15 Hickey, H.D.,Mcgillick, B.E.,Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of a 4-carboxymuconolactone decarboxylase To be Published 0 0 0 0 4GI5 Crystal Structure Of a Putative quinone reductase from Klebsiella pneumoniae (Target PSI-013613) 2012-08-08 2012-08-22 Kumar, P.R.,Hillerich, B.,Love, J.,Seidel, R.,Almo, S.C. Crystal structure of a quinone reductase from Klebsiella pneumoniae with bound FAD to be published 0 0 0 0 4GIC Crystal Structure Of a Putative Histidinol dehydrogenase (Target PSI-014034) from Methylococcus capsulatus 2012-08-08 2012-08-22 Kumar, P.R.,Hillerich, B.,Love, J.,Seidel, R.,Almo, S.C. Crystal structure of a putative Histidinol dehydrogenase from Methylococcus capsulatus to be published 0 0 0 0 3TKY 22851762 Monolignol o-methyltransferase (momt) 2011-08-29 2012-08-29 Zhang, K.,Bhuiya, M.W.,Pazo, J.R.,Miao, Y.,Kim, H.,Ralph, J.,Liu, C.J. An engineered monolignol 4-o-methyltransferase depresses lignin biosynthesis and confers novel metabolic capability in Arabidopsis. Plant Cell 2012 24 3135 3152 3U96 22564106 Crystal Structure of YopHQ357F(Catalytic Domain, Residues 163-468) in complex with pNCS 2011-10-17 2012-08-29 Ke, S.,Ho, M.C.,Zhadin, N.,Deng, H.,Callender, R. Investigation of catalytic loop structure, dynamics, and function relationship of Yersinia protein tyrosine phosphatase by temperature-jump relaxation spectroscopy and X-ray structural determination. J.Phys.Chem.B 2012 116 6166 6176 4E41 Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 2012-03-11 2012-08-29 Deng, L.,Langley, R.J.,Wang, Q.,Topalian, S.L.,Mariuzza, R.A. Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 Proc.Natl.Acad.Sci.USA 2012 0 0 0 4E42 Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 2012-03-11 2012-08-29 Deng, L.,Langley, R.J.,Wang, Q.,Topalian, S.L.,Mariuzza, R.A. Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 Proc.Natl.Acad.Sci.USA 2012 0 0 0 4GLT Crystal structure of glutathione s-transferase MFLA_2116 (target EFI-507160) from methylobacillus flagellatus kt with gsh bound 2012-08-14 2012-08-29 Patskovsky, Y.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal structure of glutathione s-transferase MFLA_2116 (target EFI-507160) from methylobacillus flagellatus kt with gsh bound To be Published 0 0 0 0 4GP1 Crystal structure of ISOPRENOID SYNTHASE A3MSH1 (TARGET EFI-501992) from pyrobaculum calidifontis complexed with DMAPP 2012-08-20 2012-08-29 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Poulter, C.D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Isoprenoid Synthase from Pyrobaculum Calidifontis To be Published 0 0 0 0 4AKY 22921071 CRYSTAL STRUCTURE OF VIRB8 FROM BRUCELLA SUIS IN COMPLEX WITH INTERACTION INHIBITOR 2-(butylamino)-8-quinolinol 2012-02-29 2012-09-05 Smith, M.A.,Coincon, M.,Paschos, A.,Jolicoeur, B.,Lavallee, P.,Sygusch, J.,Baron, C. Identification of the Binding Site of Brucella Virb8 Interaction Inhibitors. Chem.Biol. 2012 19 1041 0 4AKZ 22921071 CRYSTAL STRUCTURE OF VIRB8 FROM BRUCELLA SUIS 2012-02-29 2012-09-05 Smith, M.A.,Coincon, M.,Paschos, A.,Jolicoeur, B.,Lavallee, P.,Sygusch, J.,Baron, C. Identification of the Binding Site of Brucella Virb8 Interaction Inhibitors. Chem.Biol. 2012 19 1041 0 4FIF 22988085 Catalytic domain of human PAK4 with RPKPLVDP peptide 2012-06-08 2012-09-12 Ha, B.H.,Davis, M.J.,Chen, C.,Lou, H.J.,Gao, J.,Zhang, R.,Krauthammer, M.,Halaban, R.,Schlessinger, J.,Turk, B.E.,Boggon, T.J. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc.Natl.Acad.Sci.USA 2012 109 16107 16112 4G2K 22935026 Crystal structure of the Marburg Virus GP2 ectodomain in its post-fusion conformation 2012-07-12 2012-09-12 Koellhoffer, J.F.,Malashkevich, V.N.,Harrison, J.S.,Toro, R.,Bhosle, R.C.,Chandran, K.,Almo, S.C.,Lai, J.R. Crystal Structure of the Marburg Virus GP2 Core Domain in Its Postfusion Conformation. Biochemistry 2012 51 7665 7675 4GME Crystal structure of mannonate dehydratase (target EFI-502209) from caulobacter crescentus cb15 complexed with magnesium and d-mannonate 2012-08-15 2012-09-12 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Mannonate Dehydratase from Caulobacter Crescentus Cb15 To be Published 0 0 0 0 4GOS 25437562 Crystal structure of human B7-H4 IgV-like domain 2012-08-20 2012-09-12 Jeon, H.,Vigdorovich, V.,Garrett-Thomson, S.C.,Janakiram, M.,Ramagopal, U.A.,Abadi, Y.M.,Lee, J.S.,Scandiuzzi, L.,Ohaegbulam, K.C.,Chinai, J.M.,Zhao, R.,Yao, Y.,Mao, Y.,Sparano, J.A.,Almo, S.C.,Zang, X. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep 2014 9 1089 1098 4GOS 25437562 Crystal structure of human B7-H4 IgV-like domain 2012-08-20 2012-09-12 Jeon, H.,Vigdorovich, V.,Garrett-Thomson, S.C.,Janakiram, M.,Ramagopal, U.A.,Abadi, Y.M.,Lee, J.S.,Scandiuzzi, L.,Ohaegbulam, K.C.,Chinai, J.M.,Zhao, R.,Yao, Y.,Mao, Y.,Sparano, J.A.,Almo, S.C.,Zang, X. Structure and cancer immunotherapy of the B7 family member B7x. Cell Rep 2014 9 1089 1098 4GPS 22961381 Crystal Structure of K. lactis Dxo1 (YDR370C) 2012-08-21 2012-09-12 Chang, J.H.,Jiao, X.,Chiba, K.,Oh, C.,Martin, C.E.,Kiledjian, M.,Tong, L. Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity. Nat.Struct.Mol.Biol. 2012 19 1011 1017 4GPU 22961381 Crystal structure of K. lactis Dxo1 (YDR370C) in complex with manganese 2012-08-21 2012-09-12 Chang, J.H.,Jiao, X.,Chiba, K.,Oh, C.,Martin, C.E.,Kiledjian, M.,Tong, L. Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity. Nat.Struct.Mol.Biol. 2012 19 1011 1017 4GWB Crystal structure of putative Peptide methionine sulfoxide reductase from Sinorhizobium meliloti 1021 2012-09-01 2012-09-19 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of putative Peptide methionine sulfoxide reductase from Sinorhizobium meliloti 1021 To be Published 0 0 0 0 4GXH Crystal Structure of a Pyrrolidone-carboxylate peptidase 1 (target ID NYSGRC-012831) from Xenorhabdus bovienii SS-2004 2012-09-04 2012-09-19 Ghosh, A.,Bhoshle, R.,Toro, R.,Gizzi, A.,Hillerich, B.,Seidel, R.,Almo, S.C.,New York Structural Genomics Research Consortium Crystal Structure of a Pyrrolidone-carboxylate peptidase 1 (target ID NYSGRC-012831) from Xenorhabdus bovienii SS-2004 (CASP Target) To be Published 0 0 0 0 4H16 Crystal Structure of a short chain alcohol dehydrogenase-related dehydrogenase (target ID NYSGRC-011812) from Sinorhizobium meliloti 1021 in space group P6422 2012-09-10 2012-09-19 Ghosh, A.,Bhoshle, R.,Toro, R.,Gizzi, A.,Hillerich, B.,Seidel, R.,Almo, S.C.,New York Structural Genomics Research Consortium Crystal Structure of a short chain alcohol dehydrogenase-related dehydrogenase (target ID NYSGRC-011812) from Sinorhizobium meliloti 1021 in space group P6422 To be Published 0 0 0 0 4EKX 22927815 Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 2012-04-10 2012-09-26 Krumm, B.,Meng, X.,Wang, Z.,Xiang, Y.,Deng, J. A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. Plos Pathog. 2012 8 0 0 4FFS 22891633 Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A 2012-06-01 2012-09-26 Wang, S.,Haapalainen, A.M.,Yan, F.,Du, Q.,Tyler, P.C.,Evans, G.B.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L. A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori. Biochemistry 2012 51 6892 6894 4FFS 22891633 Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A 2012-06-01 2012-09-26 Wang, S.,Haapalainen, A.M.,Yan, F.,Du, Q.,Tyler, P.C.,Evans, G.B.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L. A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori. Biochemistry 2012 51 6892 6894 4GM6 Crystal structure of PfkB family carbohydrate kinase(TARGET EFI-502146 FROM Listeria grayi DSM 20601 2012-08-15 2012-09-26 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of PfkB family carbohydrate kinase FROM Listeria grayi To be Published 0 0 0 0 4GSM 23061982 Crystal Structure of Ni2+2-Human Arginase I 2012-08-28 2012-09-26 D'Antonio, E.L.,Hai, Y.,Christianson, D.W. Structure and function of non-native metal clusters in human arginase I. Biochemistry 2012 51 8399 8409 4GSV 23061982 Crystal Structure of the Ni2+2-Human Arginase I-ABH complex 2012-08-28 2012-09-26 D'Antonio, E.L.,Hai, Y.,Christianson, D.W. Structure and function of non-native metal clusters in human arginase I. Biochemistry 2012 51 8399 8409 4GSZ 23061982 Crystal Structure of the Zn2+5-Human Arginase I-ABH Complex 2012-08-28 2012-09-26 D'Antonio, E.L.,Hai, Y.,Christianson, D.W. Structure and function of non-native metal clusters in human arginase I. Biochemistry 2012 51 8399 8409 4GWC 23061982 Crystal Structure of Mn2+2,Zn2+-Human Arginase I 2012-09-01 2012-09-26 D'Antonio, E.L.,Hai, Y.,Christianson, D.W. Structure and function of non-native metal clusters in human arginase I. Biochemistry 2012 51 8399 8409 4GWD 23061982 Crystal Structure of the Mn2+2,Zn2+-Human Arginase I-ABH Complex 2012-09-01 2012-09-26 D'Antonio, E.L.,Hai, Y.,Christianson, D.W. Structure and function of non-native metal clusters in human arginase I. Biochemistry 2012 51 8399 8409 4H1Z Crystal structure of putative isomerase from Sinorhizobium meliloti, open loop conformation (target EFI-502104) 2012-09-11 2012-09-26 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Enolase Q92Zs5 (Target EFI-502104) from Sinorhizobium meliloti To be Published 0 0 0 0 4B63 22928747 A. fumigatus ornithine hydroxylase (SidA) bound to NADP and ornithine 2012-08-09 2012-10-03 Franceschini, S.,Fedkenheuer, M.,Vogelaar, N.J.,Robinson, H.H.,Sobrado, P.,Mattevi, A. Structural Insight Into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases. Biochemistry 2012 51 7043 0 4B64 22928747 A. fumigatus ornithine hydroxylase (SidA) bound to NADP and Lysine 2012-08-09 2012-10-03 Franceschini, S.,Fedkenheuer, M.,Vogelaar, N.J.,Robinson, H.H.,Sobrado, P.,Mattevi, A. Structural Insight Into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases. Biochemistry 2012 51 7043 0 4DI8 22475079 CRYSTAL STRUCTURE OF THE D248A mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 8.5 2012-01-11 2012-10-03 Hobbs, M.E.,Malashkevich, V.,Williams, H.J.,Xu, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Raushel, F.M. Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation. Biochemistry 2012 51 3497 3507 4DI9 22475079 CRYSTAL STRUCTURE OF THE D248A mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 6.5 2012-01-11 2012-10-03 Hobbs, M.E.,Malashkevich, V.,Williams, H.J.,Xu, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Raushel, F.M. Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation. Biochemistry 2012 51 3497 3507 4DIA 22475079 CRYSTAL STRUCTURE OF THE D248N mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 4.6 2012-01-11 2012-10-03 Hobbs, M.E.,Malashkevich, V.,Williams, H.J.,Xu, C.,Sauder, J.M.,Burley, S.K.,Almo, S.C.,Raushel, F.M. Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation. Biochemistry 2012 51 3497 3507 4F2Z 23012475 Crystal structure of RPE65 in a lipid environment 2012-05-08 2012-10-03 Kiser, P.D.,Farquhar, E.R.,Shi, W.,Sui, X.,Chance, M.R.,Palczewski, K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc.Natl.Acad.Sci.USA 2012 109 0 0 4F30 23012475 Structure of RPE65: P6522 crystal form grown in ammonium phosphate solution 2012-05-08 2012-10-03 Kiser, P.D.,Farquhar, E.R.,Shi, W.,Sui, X.,Chance, M.R.,Palczewski, K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc.Natl.Acad.Sci.USA 2012 109 0 0 4F3A 23012475 Structure of RPE65: P6522 crystal form, iridium derivative 2012-05-09 2012-10-03 Kiser, P.D.,Farquhar, E.R.,Shi, W.,Sui, X.,Chance, M.R.,Palczewski, K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc.Natl.Acad.Sci.USA 2012 109 0 0 4GQ1 23019579 Nup37 of S. pombe 2012-08-22 2012-10-03 Liu, X.,Mitchell, J.M.,Wozniak, R.W.,Blobel, G.,Fan, J. Structural evolution of the membrane-coating module of the nuclear pore complex. Proc.Natl.Acad.Sci.USA 2012 109 16498 16503 4GQ2 23019579 S. pombe Nup120-Nup37 complex 2012-08-22 2012-10-03 Liu, X.,Mitchell, J.M.,Wozniak, R.W.,Blobel, G.,Fan, J. Structural evolution of the membrane-coating module of the nuclear pore complex. Proc.Natl.Acad.Sci.USA 2012 109 16498 16503 4A2U CRP(CAP) from Myco. Tuberculosis, with cAMP 2011-09-28 2012-10-10 Kim, S.-K.,Robinson, H.,Reddy, P.T.,Gallagher, D.T. A New Crystal Form of Crp from M. Tuberculosis and Conformational Effects of Crystal Packing To be Published 0 0 0 0 4FYV 22906065 Aspartate Transcarbamoylase Complexed with dCTP 2012-07-05 2012-10-10 Cockrell, G.M.,Kantrowitz, E.R. Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase. Biochemistry 2012 51 7128 7137 4FYX 22906065 E. coli Aspartate Transcarbamoylase complexed with dCTP, UTP, and Mg2+ 2012-07-05 2012-10-10 Cockrell, G.M.,Kantrowitz, E.R. Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase. Biochemistry 2012 51 7128 7137 4FYY 22906065 E. coli Aspartate Transcarbamoylase Complexed with CTP, UTP, and Mg2+ 2012-07-05 2012-10-10 Cockrell, G.M.,Kantrowitz, E.R. Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase. Biochemistry 2012 51 7128 7137 4GEK 23676670 Crystal Structure of wild-type CmoA from E.coli 2012-08-02 2012-10-10 Kim, J.,Xiao, H.,Bonanno, J.B.,Kalyanaraman, C.,Brown, S.,Tang, X.,Al-Obaidi, N.F.,Patskovsky, Y.,Babbitt, P.C.,Jacobson, M.P.,Lee, Y.-S.,Almo, S.C. Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function Nature 2013 498 123 126 4GGJ 23064227 Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) 2012-08-06 2012-10-10 Ipsaro, J.J.,Haase, A.D.,Knott, S.R.,Joshua-Tor, L.,Hannon, G.J. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 2012 491 279 283 4GGK 23064227 Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) bound to tungstate 2012-08-06 2012-10-10 Ipsaro, J.J.,Haase, A.D.,Knott, S.R.,Joshua-Tor, L.,Hannon, G.J. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 2012 491 279 283 4GP2 Crystal structure of ISOPRENOID SYNTHASE A3MSH1 (TARGET EFI-501992) from pyrobaculum calidifontis complexed with DMAPP and Magnesium 2012-08-20 2012-10-10 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Poulter, C.D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Isoprenoid Synthase from Pyrobaculum Calidifontis To be Published 0 0 0 0 4GRF Crystal structure of thioredoxin domain of thiol-disulfide oxidoreductase BVU-2223 (Target EFI-501010) from Bacteroides vulgatus 2012-08-24 2012-10-10 Patskovsky, Y.,Sampathkumar, P.,Toro, R.,Bhosle, R.,Zencheck, W.D.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Evans, B.,Chowdhury, S.,Hammonds, J.,Al-Obaidi, N.F.,Stead, M.,Love, J.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Structure of thioredoxin domain of thiol-disulfide oxidoreductase BVU-2223 from Bacteroides vulgatus To be Published 0 0 0 0 4H6P Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a R101A substitution. 2012-09-19 2012-10-10 Buchko, G.W.,Robinson, H.,Zhang, Y. Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii To be Published 0 0 0 0 4H83 Crystal structure of Mandelate racemase/muconate lactonizing enzyme (EFI target:502127) 2012-09-21 2012-10-10 Kim, J.,Toro, R.,Bhosle, R.,Al Obaidi, N.F.,Morisco, L.L.,Wasserman, S.R.,Sojitra, S.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Stead, M.,Hillerich, B.,Love, J.,Seidel, R.D.,Imker, H.J.,Gerlt, J.A.,Almo, S.C. Crystal structure of Mandelate racemase/muconate lactonizing enzyme To be Published 0 0 0 0 4H9N Complex structure 1 of DAXX/H3.3(sub5)/H4 2012-09-24 2012-10-10 Elsasser, S.J.,Huang, H.,Lewis, P.W.,Chin, J.W.,Allis, D.C.,Patel, D.J. DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published 0 0 0 0 4HAD Crystal structure of probable oxidoreductase protein from Rhizobium etli CFN 42 2012-09-26 2012-10-10 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable oxidoreductase protein from Rhizobium etli CFN 42 To be Published 0 0 0 0 4EY4 23035744 Crystal Structure of Recombinant Human Acetylcholinesterase in the Apo state 2012-05-01 2012-10-17 Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem. 2012 55 10282 10286 4EY5 23035744 Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with (-)-huperzine A 2012-05-01 2012-10-17 Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem. 2012 55 10282 10286 4EY6 23035744 Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with (-)-galantamine 2012-05-01 2012-10-17 Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem. 2012 55 10282 10286 4EY7 23035744 Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil 2012-05-01 2012-10-17 Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem. 2012 55 10282 10286 4FUL 23021994 PI3 Kinase Gamma bound to a pyrmidine inhibitor 2012-06-28 2012-10-17 Gopalsamy, A.,Bennett, E.M.,Shi, M.,Zhang, W.G.,Bard, J.,Yu, K. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg.Med.Chem.Lett. 2012 22 6636 6641 4H9Q Complex structure 4 of DAXX(E225A)/H3.3(sub5)/H4 2012-09-24 2012-10-17 Elsasser, S.J.,Huang, H.,Lewis, P.W.,Chin, J.W.,Allis, D.C.,Patel, D.J. DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published 0 0 0 0 4H9S Complex structure 6 of DAXX/H3.3(sub7)/H4 2012-09-24 2012-10-17 Elsasser, S.J.,Huang, H.,Lewis, P.W.,Chin, J.W.,Allis, D.C.,Patel, D.J. DAXX chaperone envelops an H3.3/H4 dimer dictating H3.3-specific read out To be Published 0 0 0 0 4HB9 28246174 Crystal structure of a putative FAD containing monooxygenase from Photorhabdus luminescens subsp. laumondii TTO1 (Target PSI-012791) 2012-09-27 2012-10-17 Park, H.B.,Sampathkumar, P.,Perez, C.E.,Lee, J.H.,Tran, J.,Bonanno, J.B.,Hallem, E.A.,Almo, S.C.,Crawford, J.M. Stilbene epoxidation and detoxification in a Photorhabdus luminescens -nematode symbiosis. J.Biol.Chem. 2017 292 6680 6694 4B3N 23091002 Crystal structure of rhesus TRIM5alpha PRY/SPRY domain 2012-07-25 2012-10-24 Yang, H.,Ji, X.,Zhao, G.,Ning, J.,Zhao, Q.,Aiken, C.,Gronenborn, A.M.,Zhang, P.,Xiong, Y. Structural Insight Into HIV-1 Capsid Recognition by Rhesus Trim5Alpha Proc.Natl.Acad.Sci.USA 2012 109 18372 0 4ESV 23022319 A New Twist on the Translocation Mechanism of Helicases from the Structure of DnaB with its Substrates 2012-04-23 2012-10-24 Itsathitphaisarn, O.,Wing, R.A.,Eliason, W.K.,Wang, J.,Steitz, T.A. The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation. Cell(Cambridge,Mass.) 2012 151 267 277 4HC8 CRYSTAL STRUCTURE OF PROBABLE ENOYL-CoA HYDRATASE ECHA3 (Rv0632c, NYSGRC-019494) from Mycobacterium Tuberculosis H37Rv 2012-09-28 2012-10-24 Sampathkumar, P.,Ahmed, M.,Banu, N.,Bhosle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Fiser, A.,Gizzi, A.,Glenn, A.S.,Hammonds, J.,Hillerich, B.,Khafizov, K.,Lafleur, J.,Love, J.D.,Stead, M.,Seidel, R.,Toro, R.,Almo, S.C. Crystal structure of probable enoyl-CoA hydratase ECHA3 (Rv0632c, NYSGRC-019494) from Mycobacterium Tuberculosis H37Rv To be Published 0 0 0 0 4G8K 23084743 Intact sensor domain of human RNase L in the inactive signaling state 2012-07-23 2012-10-31 Han, Y.,Whitney, G.,Donovan, J.,Korennykh, A. Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes. Cell Rep 2012 2 902 913 4G8L 23084743 Active state of intact sensor domain of human RNase L with 2-5A bound 2012-07-23 2012-10-31 Han, Y.,Whitney, G.,Donovan, J.,Korennykh, A. Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes. Cell Rep 2012 2 902 913 4GYW 23103939 Crystal structure of human O-GlcNAc Transferase in complex with UDP and a glycopeptide 2012-09-05 2012-10-31 Lazarus, M.B.,Jiang, J.,Gloster, T.M.,Zandberg, W.F.,Whitworth, G.E.,Vocadlo, D.J.,Walker, S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat.Chem.Biol. 2012 8 966 968 4GZ3 23103939 Crystal structure of human O-GlcNAc Transferase with UDP and a thioglycopeptide 2012-09-05 2012-10-31 Lazarus, M.B.,Jiang, J.,Gloster, T.M.,Zandberg, W.F.,Whitworth, G.E.,Vocadlo, D.J.,Walker, S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat.Chem.Biol. 2012 8 966 968 4H3H 23070812 Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA poymerase II CTD peptide phosphorylated at SER-7 2012-09-13 2012-10-31 Xiang, K.,Manley, J.L.,Tong, L. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev. 2012 26 2265 2270 4H3K 23070812 Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA polymerase II CTD peptide phosphorylated at Ser-2, Ser-5 and Ser-7 2012-09-13 2012-10-31 Xiang, K.,Manley, J.L.,Tong, L. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev. 2012 26 2265 2270 4HGV Crystal structure of a fumarate hydratase 2012-10-08 2012-10-31 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of a fumarate hydratase To be Published 0 0 0 0 4HKM Crystal Structure of an Anthranilate Phosphoribosyltransferase (target ID NYSGRC-016600) from Xanthomonas campestris 2012-10-15 2012-10-31 Ghosh, A.,Ahmed, A.,Banu, R.,Bhoshle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Fiser, A.,Glenn, A.S.,Hillerich, B.,Khafizov, K.,Lafleur, J.,Love, J.D.,Seidel, R.,Stead, M.,Toro, R.,Almo, S.C. Crystal Structure of an Anthranilate Phosphoribosyltransferase (target ID NYSGRC-016600) from Xanthomonas campestris To be Published 0 0 0 0 4HL9 Crystal structure of antibiotic biosynthesis monooxygenase 2012-10-16 2012-10-31 Rice, S.,Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of antibiotic biosynthesis monooxygenase To be Published 0 0 0 0 4H22 23099021 Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1 2012-09-11 2012-11-07 Nguyen, J.B.,Modis, Y. Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1. J.Struct.Biol. 2013 181 82 88 4H5I 23109340 Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P1 form) 2012-09-18 2012-11-07 McMahon, C.,Studer, S.M.,Clendinen, C.,Dann, G.P.,Jeffrey, P.D.,Hughson, F.M. The structure of sec12 implicates potassium ion coordination in sar1 activation. J.Biol.Chem. 2012 287 43599 43606 4H5J 23109340 Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P64 form) 2012-09-18 2012-11-07 McMahon, C.,Studer, S.M.,Clendinen, C.,Dann, G.P.,Jeffrey, P.D.,Hughson, F.M. The structure of sec12 implicates potassium ion coordination in sar1 activation. J.Biol.Chem. 2012 287 43599 43606 4HN8 Crystal structure of a putative D-glucarate dehydratase from Pseudomonas mendocina ymp 2012-10-19 2012-11-07 Hegde, R.P.,Toro, R.,Burley, S.K.,Almo, S.C.,Ramagopal, U.A. Crystal structure of a putative D-glucarate dehydratase from Pseudomonas mendocina ymp To be published 0 0 0 0 4HNL Crystal structure of ENOLASE EGBG_01401 (TARGET EFI-502226) from Enterococcus gallinarum EG2 2012-10-19 2012-11-07 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.F.,Stead, M.,Love, J.,Gerlt, J.A.,Almo, S.C. Crystal structure of ENOLASE EGBG_01401 from Enterococcus gallinarum EG2 To be Published 0 0 0 0 4HPF 23129643 Structure of the human SLO3 gating ring 2012-10-23 2012-11-07 Leonetti, M.D.,Yuan, P.,Hsiung, Y.,Mackinnon, R. Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. Proc.Natl.Acad.Sci.USA 2012 109 19274 19279 4AYA 23119064 Crystal structure of ID2 HLH homodimer at 2.1A resolution 2012-06-19 2012-11-14 Wong, M.V.,Jiang, S.,Palasingam, P.,Kolatkar, P.R. A Divalent Ion is Crucial in the Structure and Dominant-Negative Function of Id Proteins, a Class of Helix-Loop-Helix Transcription Regulators. Plos One 2012 7 48591 0 4HPS Crystal Structure of a Pyrrolidone-carboxylate peptidase 1 (target ID NYSGRC-012831) from Xenorhabdus bovienii SS-2004 in space group P21 2012-10-24 2012-11-14 Ghosh, A.,Ahmed, A.,Banu, R.,Bhoshle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Fiser, A.,Glenn, A.S.,Hillerich, B.,Khafizov, K.,Lafleur, J.,Love, J.D.,Seidel, R.,Stead, M.,Toro, R.,Almo, S.C. Crystal Structure of a Pyrrolidone-carboxylate peptidase 1 (target ID NYSGRC-012831) from Xenorhabdus bovienii SS-2004 in space group P21 To be Published 0 0 0 0 3V1P 23030629 Crystal structure of the mutant Q185A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 2011-12-09 2012-11-21 Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry 2012 51 8665 8678 4HWN Crystal structure of the second Ig-C2 domain of human Fc-receptor like A (FCRLA), Isoform 9 [NYSGRC-005836] 2012-11-08 2012-11-21 Kumar, P.R.,Nathenson, S.G.,Almo, S.C. Crystal structure of the second Ig-C2 domain of the human Fc-receptor like A, Isoform 9 [NYSGRC-005836] to be published 0 0 0 0 4HWU Crystal structure of the Ig-C2 type 1 domain from mouse Fibroblast growth factor receptor 2 (FGFR2) [NYSGRC-005912] 2012-11-08 2012-11-21 Kumar, P.R.,Nathenson, S.G.,Almo, S.C. Crystal structure of the Ig-C2 type 1 domain from mouse FGFR2 [NYSGRC-005912] to be published 0 0 0 0 4G29 23151626 Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI 2012-07-11 2012-11-28 Bhaskaran, S.S.,Stebbins, C.E. Structure of the catalytic domain of the Salmonella virulence factor SseI. Acta Crystallogr.,Sect.D 2012 68 1613 1621 4G2B 23151626 Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI 2012-07-11 2012-11-28 Bhaskaran, S.S.,Stebbins, C.E. Structure of the catalytic domain of the Salmonella virulence factor SseI. Acta Crystallogr.,Sect.D 2012 68 1613 1621 4HCE 23177925 Crystal structure of the telomeric Saccharomyces cerevisiae Cdc13 OB2 domain 2012-09-29 2012-11-28 Mason, M.,Wanat, J.J.,Harper, S.,Schultz, D.C.,Speicher, D.W.,Johnson, F.B.,Skordalakes, E. Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance. Structure 2013 21 109 120 4HKS 23180775 Calcium release-activated calcium (CRAC) channel ORAI, K163W mutant 2012-10-15 2012-11-28 Hou, X.,Pedi, L.,Diver, M.M.,Long, S.B. Crystal structure of the calcium release-activated calcium channel Orai. Science 2012 338 1308 1313 4HZ2 Crystal structure of glutathione s-transferase xaut_3756 (target efi-507152) from xanthobacter autotrophicus py2 2012-11-14 2012-11-28 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.F.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C. Crystal structure of glutathione s-transferase xaut_3756 from xanthobacter autotrophicus py2 To be Published 0 0 0 0 4HZ4 Crystal structure of glutathione s-transferase b4xh91 (target efi-501787) from actinobacillus pleuropneumoniae 2012-11-14 2012-11-28 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.F.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C. Crystal structure of glutathione s-transferase b4xh91 from Actinobacillus pleuropneumoniae To be Published 0 0 0 0 3UXO 23651085 Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme 2011-12-05 2012-12-05 Gridley, C.L.,Rangarajan, S.,Firbank, S.,Dalal, S.,Sweasy, J.B.,Jaeger, J. Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta. Biochemistry 2013 52 4422 4432 4H4M 23163887 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor 2012-09-17 2012-12-05 Frey, K.M.,Bollini, M.,Mislak, A.C.,Cisneros, J.A.,Gallardo-Macias, R.,Jorgensen, W.L.,Anderson, K.S. Crystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design. J.Am.Chem.Soc. 2012 134 19501 19503 4H4O 23163887 Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with (E)-3-(3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)- 4-fluorophenoxy)-5-fluorophenyl)acrylonitrile (JLJ506), A Non-nucleoside inhibitor 2012-09-17 2012-12-05 Frey, K.M.,Bollini, M.,Mislak, A.C.,Cisneros, J.A.,Gallardo-Macias, R.,Jorgensen, W.L.,Anderson, K.S. Crystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design. J.Am.Chem.Soc. 2012 134 19501 19503 4I0K 23583036 Crystal structure of murine B7-H3 extracellular domain 2012-11-16 2012-12-05 Vigdorovich, V.,Ramagopal, U.A.,Lazar-Molnar, E.,Sylvestre, E.,Lee, J.S.,Hofmeyer, K.A.,Zang, X.,Nathenson, S.G.,Almo, S.C. Structure and T cell inhibition properties of B7 family member, B7-H3. Structure 2013 21 707 717 4F6L 23070851 Crystal structure of Aureusimine biosynthetic cluster reductase domain 2012-05-14 2012-12-12 Wyatt, M.A.,Mok, M.C.,Junop, M.,Magarvey, N.A. Heterologous expression and structural characterisation of a pyrazinone natural product assembly line. Chembiochem 2012 13 2408 2415 4GZL 23284172 Crystal structure of RAC1 Q61L mutant 2012-09-06 2012-12-12 Davis, M.J.,Ha, B.H.,Holman, E.C.,Halaban, R.,Schlessinger, J.,Boggon, T.J. RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc.Natl.Acad.Sci.USA 2013 110 912 917 4HUJ Crystal structure of a hypothetical protein SMa0349 from Sinorhizobium meliloti 2012-11-02 2012-12-12 Rice, S.,Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of a hypothetical protein SMa0349 from Sinorhizobium meliloti To be Published 0 0 0 0 4HY3 Crystal structure of a phosphoglycerate oxidoreductase from rhizobium etli 2012-11-12 2012-12-12 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a phosphoglycerate oxidoreductase from rhizobium etli To be Published 0 0 0 0 4I6K Crystal structure of probable 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE ABAYE1769 (TARGET EFI-505029) from Acinetobacter baumannii with citric acid bound 2012-11-29 2012-12-12 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.F.,Stead, M.,Love, J.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C. CRYSTAL STRUCTURE OF PROBABLE 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE (TARGET EFI-505029) FROM Acinetobacter baumannii To be Published 0 0 0 0 3V5C Crystal structure of the mutant E234A of Galacturonate Dehydratase from GEOBACILLUS SP. complexed with Mg 2011-12-16 2012-12-19 Fedorov, A.A.,Fedorov, E.V.,Groninger-Poe, F.,Gerlt, J.A.,Almo, S.C. Crystal structure of the mutant E234A of Galacturonate Dehydratase from GEOBACILLUS SP. complexed with Mg To be Published 0 0 0 0 3V5F Crystal structure of the mutant E234A of Galacturonate Dehydratase from GEOBACILLUS SP. complexed with Mg 2011-12-16 2012-12-19 Fedorov, A.A.,Fedorov, E.V.,Groninger-Poe, F.,Gerlt, J.A.,Almo, S.C. Crystal structure of the mutant E234A of Galacturonate Dehydratase from GEOBACILLUS SP. complexed with Mg To be Published 0 0 0 0 4G59 23169621 Crystal structure of the murine cytomegalovirus MHC-I homolog m152 with ligand RAE-1 gamma 2012-07-17 2012-12-19 Wang, R.,Natarajan, K.,Revilleza, M.J.,Boyd, L.F.,Zhi, L.,Zhao, H.,Robinson, H.,Margulies, D.H. Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1gamma reveals a paradigm for MHC/MHC interaction in immune evasion. Proc.Natl.Acad.Sci.USA 2012 109 0 0 4HKT Crystal structure of a putative myo-inositol dehydrogenase from Sinorhizobium meliloti 1021 (Target PSI-012312) 2012-10-15 2012-12-19 Sampathkumar, P.,Gizzi, A.,Ahmed, M.,Banu, N.,Bhosle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Fiser, A.,Glenn, A.S.,Hammonds, J.,Hillerich, B.,Khafizov, K.,Lafleur, J.,Love, J.D.,Stead, M.,Seidel, R.,Toro, R.,Almo, S.C. Crystal structure of a putative myo-inositoldehydrogenase from Sinorhizobium meliloti 1021 (Target PSI-012312) to be published 0 0 0 0 4FXM 23181361 Crystal structure of the complex of a human telomeric repeat G-quadruplex and N-methyl mesoporphyrin IX (P21212) 2012-07-03 2012-12-26 Nicoludis, J.M.,Miller, S.T.,Jeffrey, P.D.,Barrett, S.P.,Rablen, P.R.,Lawton, T.J.,Yatsunyk, L.A. Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA. J.Am.Chem.Soc. 2012 134 20446 20456 4GRH 23230967 Crystal structure of pabB of Stenotrophomonas maltophilia 2012-08-24 2012-12-26 Bera, A.K.,Atanasova, V.,Dhanda, A.,Ladner, J.E.,Parsons, J.F. Structure of Aminodeoxychorismate Synthase from Stenotrophomonas maltophilia. Biochemistry 2012 51 10208 10217 4HS4 Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a Y129N substitution. 2012-10-29 2012-12-26 Buchko, G.W.,Zhang, Y.,Robinson, H. Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii To be Published 0 0 0 0 4IAO 23307867 Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4 2012-12-07 2012-12-26 Hsu, H.C.,Wang, C.L.,Wang, M.,Yang, N.,Chen, Z.,Sternglanz, R.,Xu, R.M. Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding Genes Dev. 2013 27 64 73 4IAO 23307867 Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4 2012-12-07 2012-12-26 Hsu, H.C.,Wang, C.L.,Wang, M.,Yang, N.,Chen, Z.,Sternglanz, R.,Xu, R.M. Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding Genes Dev. 2013 27 64 73 4DQ5 23209446 Structural Investigation of Bacteriophage Phi6 Lysin (WT) 2012-02-15 2013-01-02 Dessau, M.,Goldhill, D.,McBride, R.,McBride, R.L.,Turner, P.E.,Modis, Y. Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS Genet 2012 8 0 0 4DQ7 23209446 Structural Investigation of Bacteriophage Phi6 Lysin (V207F mutant) 2012-02-15 2013-01-02 Dessau, M.,Goldhill, D.,McBride, R.,McBride, R.L.,Turner, P.E.,Modis, Y. Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS Genet 2012 8 0 0 4DQJ 23209446 Structural Investigation of Bacteriophage Phi6 Lysin (in complex with chitotetraose) 2012-02-16 2013-01-02 Dessau, M.,Goldhill, D.,McBride, R.,McBride, R.L.,Turner, P.E.,Modis, Y. Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS Genet 2012 8 0 0 4F4W 23245850 Y-family DNA polymerase chimera Dbh-Dpo4-Dpo4 #1 2012-05-11 2013-01-02 Wilson, R.C.,Jackson, M.A.,Pata, J.D. Y-family polymerase conformation is a major determinant of fidelity and translesion specificity. Structure 2013 21 20 31 3VCC CRYSTAL STRUCTURE OF D-Galacturonate Dehydratase from GEOBACILLUS SP. complexed with Mg 2012-01-03 2013-01-09 Fedorov, A.A.,Fedorov, E.V.,Groninger-Poe, F.,Gerlt, J.A.,Almo, S.C. CRYSTAL STRUCTURE OF D-Galacturonate Dehydratase from GEOBACILLUS SP. complexed with Mg To be Published 0 0 0 0 3VE7 Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP 2012-01-07 2013-01-09 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula complexed with inhibitor BMP To be Published 0 0 0 0 3VE9 Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula 2012-01-07 2013-01-09 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Metallosphaera sedula To be Published 0 0 0 0 4DBE Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP 2012-01-14 2013-01-16 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP To be Published 0 0 0 0 4GRA 23256751 Crystal structure of SULT1A1 bound with PAP 2012-08-24 2013-01-16 Cook, I.,Wang, T.,Almo, S.C.,Kim, J.,Falany, C.N.,Leyh, T.S. The gate that governs sulfotransferase selectivity. Biochemistry 2013 52 415 424 4HNT 23286247 crystal structure of F403A mutant of S. aureus Pyruvate carboxylase 2012-10-21 2013-01-16 Yu, L.P.,Chou, C.Y.,Choi, P.H.,Tong, L. Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry 2013 52 488 496 4HNU 23286247 crystal structure of K442E mutant of S. aureus Pyruvate carboxylase 2012-10-21 2013-01-16 Yu, L.P.,Chou, C.Y.,Choi, P.H.,Tong, L. Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry 2013 52 488 496 4HNV 23286247 Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase 2012-10-21 2013-01-16 Yu, L.P.,Chou, C.Y.,Choi, P.H.,Tong, L. Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry 2013 52 488 496 4IG8 23319625 Structural basis for cytosolic double-stranded RNA surveillance by human OAS1 2012-12-16 2013-01-16 Donovan, J.,Dufner, M.,Korennykh, A. Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. Proc.Natl.Acad.Sci.USA 2013 110 1652 1657 4IHC Crystal structure of probable mannonate dehydratase Dd703_0947 (target EFI-502222) from Dickeya dadantii Ech703 2012-12-18 2013-01-16 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.F.,Stead, M.,Love, J.,Gerlt, J.A.,Almo, S.C. Crystal structure of mannonate dehydratase Dd703_0947 from Dickeya dadantii Ech703 To be Published 0 0 0 0 4INF Crystal structure of amidohydrolase saro_0799 (target efi-505250) from novosphingobium aromaticivorans dsm 12444 with bound calcium 2013-01-04 2013-01-16 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C. Crystal structure of amidohydrolase sarp_0799 (target efi-505250) from novosphingobium aromaticivorans To be Published 0 0 0 0 4DF0 Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus 2012-01-22 2013-01-23 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus To be Published 0 0 0 0 4DF1 Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus complexed with inhibitor BMP 2012-01-22 2013-01-23 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus complexed with inhibitor BMP To be Published 0 0 0 0 4FGN 23269808 Crystal structure of the SV40 large T-antigen origin bining domain bound to Site I DNA 2012-06-04 2013-01-23 Meinke, G.,Phelan, P.J.,Harrison, C.J.,Bullock, P.A. Analysis of the Costructure of the Simian Virus 40 T-Antigen Origin Binding Domain with Site I Reveals a Correlation between GAGGC Spacing and Spiral Assembly. J.Virol. 2013 87 2923 2934 4HSZ Structure of truncated (delta8C) S100A4 2012-10-31 2013-01-30 Ramagopal, U.A.,Dulyaninova, N.G.,Kumar, P.R.,Almo, S.C.,Bresnick, A.R. Structure of truncated (delta8C) S100A4 To be Published 0 0 0 0 4HZA Crystal Structure of the Immunoglobulin variable domain of Nectin-2 in monoclinic form 2012-11-14 2013-01-30 Ramagopal, U.A.,Samanta, D.,Nathenson, S.G.,Almo, S.C. Crystal Structure of the Immunoglobulin variable domain of Nectin-2 in monoclinic form To be published 0 0 0 0 4IGJ Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, target EFI-507175 2012-12-17 2013-01-30 Kim, J.,Toro, R.,Bhosle, R.,Al Obaidi, N.F.,Morisco, L.L.,Wasserman, S.R.,Sojitra, S.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Hillerich, B.,Love, J.,Seidel, R.D.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal structure of Maleylacetoacetate isomerase from Anaeromyxobacter dehalogenans 2CP-1, target EFI-507175 To be Published 0 0 0 0 4IT1 Crystal structure of enolase pfl01_3283 (target efi-502286) from pseudomonas fluorescens pf0-1 with bound magnesium, potassium and tartrate 2013-01-17 2013-01-30 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Enolase Pfl01_3283 from Pseudomonas Fluorescens To be Published 0 0 0 0 4ITY 23583962 Crystal structure of Leishmania mexicana arginase 2013-01-19 2013-01-30 D'Antonio, E.L.,Ullman, B.,Roberts, S.C.,Dixit, U.G.,Wilson, M.E.,Hai, Y.,Christianson, D.W. Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Arch.Biochem.Biophys. 2013 535 163 176 4IU0 23583962 Crystal structure of Leishmania mexicana arginase in complex with inhibitor ABH 2013-01-19 2013-01-30 D'Antonio, E.L.,Ullman, B.,Roberts, S.C.,Dixit, U.G.,Wilson, M.E.,Hai, Y.,Christianson, D.W. Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Arch.Biochem.Biophys. 2013 535 163 176 4IU1 23583962 Crystal structure of Leishmania mexicana arginase in complex with inhibitor nor-NOHA 2013-01-19 2013-01-30 D'Antonio, E.L.,Ullman, B.,Roberts, S.C.,Dixit, U.G.,Wilson, M.E.,Hai, Y.,Christianson, D.W. Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Arch.Biochem.Biophys. 2013 535 163 176 4IU4 23583962 Crystal structure of Leishmania mexicana arginase in complex with inhibitor BEC 2013-01-19 2013-01-30 D'Antonio, E.L.,Ullman, B.,Roberts, S.C.,Dixit, U.G.,Wilson, M.E.,Hai, Y.,Christianson, D.W. Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Arch.Biochem.Biophys. 2013 535 163 176 4IU5 23583962 Crystal structure of Leishmania mexicana arginase in complex with catalytic product L-ornithine 2013-01-19 2013-01-30 D'Antonio, E.L.,Ullman, B.,Roberts, S.C.,Dixit, U.G.,Wilson, M.E.,Hai, Y.,Christianson, D.W. Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections. Arch.Biochem.Biophys. 2013 535 163 176 4DKY 24916461 Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Ra] 2012-02-05 2013-02-06 Bhowmick, T.,Ghosh, S.,Dixit, K.,Ganesan, V.,Ramagopal, U.A.,Dey, D.,Sarma, S.P.,Ramakumar, S.,Nagaraja, V. Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors Nat Commun 2014 5 4124 4124 4EAR 23438750 Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate 2012-03-22 2013-02-06 Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L. Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol. 2013 20 212 222 4EB8 23438750 Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate 2012-03-23 2013-02-06 Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L. Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol. 2013 20 212 222 4ECE 23438750 Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine 2012-03-26 2013-02-06 Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L. Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol. 2013 20 212 222 4G1Q 23422558 Crystal structure of HIV-1 reverse transcriptase (RT) in complex with Rilpivirine (TMC278, Edurant), a non-nucleoside rt-inhibiting drug 2012-07-11 2013-02-06 Kuroda, D.G.,Bauman, J.D.,Challa, J.R.,Patel, D.,Troxler, T.,Das, K.,Arnold, E.,Hochstrasser, R.M. Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase. Nat Chem 2013 5 174 181 4GKA 23438750 Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with phosphate 2012-08-10 2013-02-06 Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L. Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol. 2013 20 212 222 4GYF Crystal structure of histidinol phosphate phosphatase (HISK) from Lactococcus lactis subsp. lactis Il1403 complexed with ZN, L-histidinol and phosphate 2012-09-05 2013-02-06 Fedorov, A.A.,Fedorov, E.V.,Ghodge, S.,Raushel, F.M.,Almo, S.C. Crystal structure of histidinol phosphate phosphatase (HISK) from Lactococcus lactis subsp. lactis Il1403 complexed with ZN, L-histidinol and phosphate To be Published 0 0 0 0 4HLU 23359690 Structure of the EcfA-A' heterodimer bound to ADP 2012-10-17 2013-02-06 Karpowich, N.K.,Wang, D.N. Assembly and mechanism of a group II ECF transporter. Proc.Natl.Acad.Sci.USA 2013 110 2534 2539 4IFB Crystal structure of SULT 2A1 LLGG mutant with PAPS 2012-12-14 2013-02-06 Kim, J.,Toro, R.,Bhosle, R.,Cook, I.,Wang, T.,Falany, C.N.,Leyh, T.S.,Almo, S.C. Sulfotransferase Selectivity at the Molecular level To be Published 0 0 0 0 4IW9 Crystal structure of glutathione s-transferase mha_0454 (target efi-507015) from mannheimia haemolytica, gsh complex 2013-01-23 2013-02-06 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Probable Glutathione S-Transferase Mha_0454 (Target Efi-507015) from Mannheimia Haemolytica To be Published 0 0 0 0 3VAL 23376934 Structure of U2AF65 variant with BrU5C1 DNA 2011-12-29 2013-02-13 Jenkins, J.L.,Agrawal, A.A.,Gupta, A.,Green, M.R.,Kielkopf, C.L. U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs. Nucleic Acids Res. 2013 41 3859 3873 3VYY 23361462 Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9) 2012-10-05 2013-02-13 Fu, Q.,Yuan, Y.A. Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9). Nucleic Acids Res. 2013 41 3457 3470 4DBD Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus 2012-01-14 2013-02-13 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus To be Published 0 0 0 0 4GZY 23374340 Crystal structures of bacterial RNA Polymerase paused elongation complexes 2012-09-06 2013-02-13 Weixlbaumer, A.,Leon, K.,Landick, R.,Darst, S.A. Structural basis of transcriptional pausing in bacteria. Cell(Cambridge,Mass.) 2013 152 431 441 4HYR Structure of putative Glucarate dehydratase from Acidaminococcus sp. D21 with unusual static disorder 2012-11-14 2013-02-13 Hegde, R.P.,Toro, R.,Burley, S.K.,Almo, S.C.,Ramagopal, U.A.,New York Structural Genomics Research Consortium (NYSGRC) Structure of putative Glucarate dehydratase from Acidaminococcus sp. D21 with unusual static disorder To be published 0 0 0 0 4II2 23416107 Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4, ubiquitin, and ATP/Mg 2012-12-19 2013-02-13 Olsen, S.K.,Lima, C.D. Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer. Mol.Cell 2013 49 884 896 4IFQ 23499021 Crystal structure of Saccharomyces cerevisiae NUP192, residues 2 to 960 [ScNup192(2-960)] 2012-12-14 2013-02-20 Sampathkumar, P.,Kim, S.J.,Upla, P.,Rice, W.J.,Phillips, J.,Timney, B.L.,Pieper, U.,Bonanno, J.B.,Fernandez-Martinez, J.,Hakhverdyan, Z.,Ketaren, N.E.,Matsui, T.,Weiss, T.M.,Stokes, D.L.,Sauder, J.M.,Burley, S.K.,Sali, A.,Rout, M.P.,Almo, S.C. Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex. Structure 2013 21 560 571 4IOY 23417676 Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT 2013-01-08 2013-02-20 Kemble, D.J.,Whitby, F.G.,Robinson, H.,McCullough, L.L.,Formosa, T.,Hill, C.P. Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT. J.Biol.Chem. 2013 288 10188 10194 4J2U Crystal structure of an enoyl-CoA hydratase from Rhodobacter sphaeroides 2.4.1 2013-02-05 2013-02-20 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of an enoyl-CoA hydratase from Rhodobacter sphaeroides 2.4.1 To be Published 0 0 0 0 4F8K 23457445 Molecular analysis of the interaction between the prostacyclin receptor and the first PDZ domain of PDZK1 2012-05-17 2013-02-27 Birrane, G.,Mulvaney, E.P.,Pal, R.,Kinsella, B.T.,Kocher, O. Molecular Analysis of the Prostacyclin Receptor's Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1. Plos One 2013 8 0 0 4GBT 23449783 Structural characterization of H-1 Parvovirus: comparison of infectious virions to replication defective particles 2012-07-27 2013-02-27 Halder, S.,Nam, H.J.,Govindasamy, L.,Vogel, M.,Dinsart, C.,Salome, N.,McKenna, R.,Agbandje-McKenna, M. Structural characterization of h-1 parvovirus: comparison of infectious virions to empty capsids. J.Virol. 2013 87 5128 5140 4GC3 23327428 Crystal structure of L-HISTIDINOL PHOSPHATE PHOSPHATASE (HISK) from Lactococcus lactis subsp. lactis Il1403 complexed with ZN and sulfate 2012-07-29 2013-02-27 Ghodge, S.V.,Fedorov, A.A.,Fedorov, E.V.,Hillerich, B.,Seidel, R.,Almo, S.C.,Raushel, F.M. Structural and Mechanistic Characterization of l-Histidinol Phosphate Phosphatase from the Polymerase and Histidinol Phosphatase Family of Proteins. Biochemistry 2013 52 1101 1112 4GK8 23327428 Crystal structure of histidinol phosphate phosphatase (HISK) from Lactococcus lactis subsp. lactis Il1403 complexed with ZN and L-histidinol arsenate 2012-08-10 2013-02-27 Ghodge, S.V.,Fedorov, A.A.,Fedorov, E.V.,Hillerich, B.,Seidel, R.,Almo, S.C.,Raushel, F.M. Structural and Mechanistic Characterization of l-Histidinol Phosphate Phosphatase from the Polymerase and Histidinol Phosphatase Family of Proteins. Biochemistry 2013 52 1101 1112 4H4F 23430245 Crystal structure of human chymotrypsin C (CTRC) bound to inhibitor eglin c from Hirudo medicinalis 2012-09-17 2013-02-27 Batra, J.,Szabo, A.,Caulfield, T.R.,Soares, A.S.,Sahin-Toth, M.,Radisky, E.S. Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation. J.Biol.Chem. 2013 288 9848 9859 4J2F Crystal structure of a glutathione transferase family member from Ricinus communis, target EFI-501866 2013-02-04 2013-02-27 Kim, J.,Toro, R.,Bhosle, R.,Al Obaidi, N.F.,Morisco, L.L.,Wasserman, S.R.,Sojitra, S.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Hillerich, B.,Love, J.,Seidel, R.D.,Imker, H.J.,Armstrong, R.N.,Gerlt, J.A.,Almo, S.C. Crystal structure of a glutathione transferase family member from Ricinus communis, target EFI-501866 TO BE PUBLISHED 0 0 0 0 4DBW 23432095 Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 2'-desmethyl-indomethacin 2012-01-16 2013-03-06 Liedtke, A.J.,Adeniji, A.O.,Chen, M.,Byrns, M.C.,Jin, Y.,Christianson, D.W.,Marnett, L.J.,Penning, T.M. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17 beta-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J.Med.Chem. 2013 56 2429 2446 4HRE 23415230 Crystal Structure of p11/Annexin A2 Heterotetramer in Complex with SMARCA3 Peptide 2012-10-27 2013-03-06 Oh, Y.S.,Gao, P.,Lee, K.W.,Ceglia, I.,Seo, J.S.,Zhang, X.,Ahn, J.H.,Chait, B.T.,Patel, D.J.,Kim, Y.,Greengard, P. SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action. Cell(Cambridge,Mass.) 2013 152 831 843 4J3Z Crystal structure of mandelate racemase/muconate lactonizing enzyme from Jannaschia sp. CCS1 2013-02-06 2013-03-06 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of mandelate racemase/muconate lactonizing enzyme from Jannaschia sp. CCS1 To be Published 0 0 0 0 4JDP Crystal structure of probable p-nitrophenyl phosphatase (pho2) (target EFI-501307) from Archaeoglobus fulgidus DSM 4304 with Magnesium bound 2013-02-25 2013-03-06 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.F.,Stead, M.,Love, J.,Allen, K.N.,Dunaway-Mariano, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of probable p-nitrophenyl phosphatase from Archaeoglobus fulgidus. To be Published 0 0 0 0 4I15 23409953 Crystal structure of TbrPDEB1 2012-11-20 2013-03-13 Jansen, C.,Wang, H.,Kooistra, A.J.,de Graaf, C.,Orrling, K.M.,Tenor, H.,Seebeck, T.,Bailey, D.,de Esch, I.J.,Ke, H.,Leurs, R. Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure. J.Med.Chem. 2013 56 2087 2096 4J6G 25087510 CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX 2013-02-11 2013-03-13 Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C. Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure 2014 22 1252 1262 4JB3 Crystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loop 2013-02-19 2013-03-13 Vetting, M.W.,Toro, R.,Bhosle, R.,Kumar, P.R.,Ghosh, A.,Al Obaidi, N.F.,Stead, M.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Hillerich, B.,Love, J.,Seidel, R.D.,Imker, H.J.,Dunaway-Mariano, D.,Allen, K.N.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of bt_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loop To be Published 0 0 0 0 4JCS Crystal structure of Enoyl-CoA hydratase/isomerase from Cupriavidus metallidurans CH34 2013-02-22 2013-03-13 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of Enoyl-CoA hydratase/isomerase from Cupriavidus metallidurans CH34 To be Published 0 0 0 0 4JCU Crystal structure of a 5-carboxymethyl-2-hydroxymuconate isomerase from Deinococcus radiodurans R1 2013-02-22 2013-03-13 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a 5-carboxymethyl-2-hydroxymuconate isomerase from Deinococcus radiodurans R1 To be Published 0 0 0 0 4JED Crystal structure of glutathione s-transferase mrad2831_1084 (target efi-507060) from methylobacterium radiotolerans jcm 2831, complex with glutathione sulfonate 2013-02-26 2013-03-13 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of glutathione S-transferase (TARGET EFI-507060) from Methylobacterium radiotolerans To be Published 0 0 0 0 4JGJ Crystal structure of the Ig-like D1 domain from mouse Carcinoembryogenic antigen-related cell adhesion molecule 15 (CEACAM15) [PSI-NYSGRC-005691] 2013-03-01 2013-03-13 Kumar, P.R.,Bonanno, J.,Nathenson, S.G.,Almo, S.C. Crystal structure of the Ig-like D1 domain of CEACAM15 from Mus musculus [NYSGRC-005691] to be published 0 0 0 0 4IX7 23468431 Crystal Structure of the insv-BEN domain complexed to its DNA target site 2013-01-24 2013-03-20 Dai, Q.,Ren, A.,Westholm, J.O.,Serganov, A.A.,Patel, D.J.,Lai, E.C. The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. Genes Dev. 2013 27 602 614 4J1R Crystal Structure of GSK3b in complex with inhibitor 15R 2013-02-01 2013-03-20 Wang, Y.,Wach, J.,Sheehan, P.,Zhong, C.,Zhan, C.,Harris, R.,Almo, S.C.,Bishop, J.,Haggarty, S.,Ramek, A.,Berry, K.,O'Herin, C.,Koehler, A.N.,Hung, A.W.,Young, D.W. Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published 0 0 0 0 4J6F Crystal structure of putative alcohol dehydrogenase from Sinorhizobium meliloti 1021, NYSGRC-Target 012230 2013-02-11 2013-03-20 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of putative alcohol dehydrogenase from Sinorhizobium meliloti 1021, NYSGRC-Target 012230 To be Published 0 0 0 0 4J71 Crystal Structure of GSK3b in complex with inhibitor 1R 2013-02-12 2013-03-20 Wang, Y.,Wach, J.,Sheehan, P.,Zhong, C.,Zhan, C.,Harris, R.,Almo, S.C.,Bishop, J.,Haggarty, S.,Ramek, A.,Berry, K.,O'Herin, C.,Koehler, A.N.,Hung, A.W.,Young, D.W. Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published 0 0 0 0 4JBB Crystal structure of Glutathione S-transferase A6TBY7(Target EFI-507184) from Klebsiella pneumoniae MGH 78578, GSH complex 2013-02-19 2013-03-20 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Glutathione S-Transferase A6Tby7 (Target Efi-507184) from Klebsiella Pneumoniae To be Published 0 0 0 0 4GF3 23519663 Structure of a SycH-YopH Chaperone-Effector Complex 2012-08-02 2013-03-27 Vujanac, M.,Stebbins, C.E. Context-dependent protein folding of a virulence peptide in the bacterial and host environments: structure of an SycH-YopH chaperone-effector complex. Acta Crystallogr.,Sect.D 2013 69 546 554 4ICG 23515315 N-terminal dimerization domain of H-NS in complex with Hha (Salmonella Typhimurium) 2012-12-10 2013-03-27 Ali, S.S.,Whitney, J.C.,Stevenson, J.,Robinson, H.,Howell, P.L.,Navarre, W.W. Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex. J.Biol.Chem. 2013 288 13356 13369 4J7L 23523372 Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions 2013-02-13 2013-03-27 Jiao, X.,Chang, J.H.,Kilic, T.,Tong, L.,Kiledjian, M. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol.Cell 2013 50 104 115 4J7M 23523372 Crystal structure of mouse DXO in complex with substrate mimic RNA and calcium ion 2013-02-13 2013-03-27 Jiao, X.,Chang, J.H.,Kilic, T.,Tong, L.,Kiledjian, M. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol.Cell 2013 50 104 115 4J7N 23523372 Crystal structure of mouse DXO in complex with M7GPPPG cap 2013-02-13 2013-03-27 Jiao, X.,Chang, J.H.,Kilic, T.,Tong, L.,Kiledjian, M. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol.Cell 2013 50 104 115 4JJH Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624] 2013-03-07 2013-03-27 Kumar, P.R.,Nathenson, S.G.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC),Atoms-to-Animals: The Immune Function Network (IFN) Crystal structure of the D1 domain of human Nectin-4 extracellular fragment [NYSGRC-005624] to be published 0 0 0 0 4JKS Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with DMSO, NYSGRC Target 14306 2013-03-11 2013-03-27 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with DMSO, NYSGRC Target 14306 To be Published 0 0 0 0 4JKU Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with quinaldic acid, NYSGRC Target 14306 2013-03-11 2013-03-27 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with quinaldic acid, NYSGRC Target 14306 To be Published 0 0 0 0 4GYO 23526881 Crystal Structure of Rap Protein Complexed with Competence and Sporulation Factor 2012-09-05 2013-04-03 Parashar, V.,Jeffrey, P.D.,Neiditch, M.B. Conformational change-induced repeat domain expansion regulates rap phosphatase quorum-sensing signal receptors. Plos Biol. 2013 11 0 0 4I1A 23526881 Crystal Structure of the Apo Form of RapI 2012-11-20 2013-04-03 Parashar, V.,Jeffrey, P.D.,Neiditch, M.B. Conformational change-induced repeat domain expansion regulates rap phosphatase quorum-sensing signal receptors. Plos Biol. 2013 11 0 0 4IYM Crystal structure of putative methylmalonate-semialdehyde dehydrogenase from Sinorhizobium meliloti 1021 complexed with NAD, target 011934 2013-01-28 2013-04-03 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Zenchek, W.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of putative methylmalonate-semialdehyde dehydrogenase from Sinorhizobium meliloti 1021 complexed with NAD, target 011934 To be Published 0 0 0 0 4JLQ 23535894 Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2 2013-03-12 2013-04-03 Soniat, M.,Sampathkumar, P.,Collett, G.,Gizzi, A.S.,Banu, R.N.,Bhosle, R.C.,Chamala, S.,Chowdhury, S.,Fiser, A.,Glenn, A.S.,Hammonds, J.,Hillerich, B.,Khafizov, K.,Love, J.D.,Matikainen, B.,Seidel, R.D.,Toro, R.,Rajesh Kumar, P.,Bonanno, J.B.,Chook, Y.M.,Almo, S.C. Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. J.Struct.Funct.Genom. 2013 14 31 35 4IZ5 23575685 Structure of the complex between ERK2 phosphomimetic mutant and PEA-15 2013-01-29 2013-04-10 Mace, P.D.,Wallez, Y.,Egger, M.F.,Dobaczewska, M.K.,Robinson, H.,Pasquale, E.B.,Riedl, S.J. Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun 2013 4 1681 1681 4IZ7 23575685 Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain 2013-01-29 2013-04-10 Mace, P.D.,Wallez, Y.,Egger, M.F.,Dobaczewska, M.K.,Robinson, H.,Pasquale, E.B.,Riedl, S.J. Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun 2013 4 1681 1681 4IZA 23575685 Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain 2013-01-29 2013-04-10 Mace, P.D.,Wallez, Y.,Egger, M.F.,Dobaczewska, M.K.,Robinson, H.,Pasquale, E.B.,Riedl, S.J. Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nat Commun 2013 4 1681 1681 4IZM 23563139 Crystal structure of GltPh L66C-S300C mutant crosslinked with divalent mercury 2013-01-30 2013-04-10 Reyes, N.,Oh, S.,Boudker, O. Binding thermodynamics of a glutamate transporter homolog. Nat.Struct.Mol.Biol. 2013 20 634 640 4J3H 23479651 Ring cycle for dilating and constricting the nuclear pore: structure of a Nup54 homo-tetramer. 2013-02-05 2013-04-10 Solmaz, S.R.,Blobel, G.,Melcak, I. Ring cycle for dilating and constricting the nuclear pore. Proc.Natl.Acad.Sci.USA 2013 110 5858 5863 4JYX Crystal structure of polyprenyl synthase PATL_3739 (TARGET EFI-509195) FROM PSEUDOALTEROMONAS ATLANTICA, COMPLEX WITH INORGANIC PHOSPHATE AND AN UNKNOWN LIGAND 2013-04-01 2013-04-10 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Poulter, C.D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Isoprenoid Synthase Patl_3739 from Pseudoalteromonas Atlantica To be Published 0 0 0 0 4HDI 23911417 Crystal Structure of 3E5 IgG3 FAB from mus musculus 2012-10-02 2013-04-17 Eryilmaz, E.,Janda, A.,Kim, J.,Cordero, R.J.,Cowburn, D.,Casadevall, A. Global structures of IgG isotypes expressing identical variable regions. Mol.Immunol. 2013 56 588 598 4JOT Crystal structure of enoyl-CoA hydrotase from Deinococcus radiodurans R1 2013-03-18 2013-04-17 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of enoyl-CoA hydrotase from Deinococcus radiodurans R1 To be Published 0 0 0 0 4JXK Crystal Structure of Oxidoreductase ROP_24000 (Target EFI-506400) from Rhodococcus opacus B4 2013-03-28 2013-04-17 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Oxidoreductase Rop_24000 (Target EFI-506400) from Rhodococcus Opacus To be Published 0 0 0 0 4JXY CRYSTAL STRUCTURE OF POLYPRENYL SYNTHASE PATL_3739 (TARGET EFI-509195) FROM Pseudoalteromonas atlantica 2013-03-28 2013-04-17 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Poulter, C.D.,Gerlt, J.A.,Almo, S.C. CRYSTAL STRUCTURE OF ISOPRENOID SYNTHASE PATL_3739 FROM Pseudoalteromonas atlantica To be Published 0 0 0 0 4JHS Crystal structure of a C-terminal two domain fragment of human beta-2-glycoprotein 1 2013-03-05 2013-04-24 Bonanno, J.B.,Toro, R.,Gizzi, A.,Chan, M.K.,Garrett-Thomson, S.C.,Patel, H.,Lim, S.,Matikainen, B.,Celikgil, A.,Garforth, S.,Hillerich, B.,Seidel, R.,Rand, J.H.,Almo, S.C. Crystal structure of a C-terminal two domain fragment of human beta-2-glycoprotein 1 To be Published 0 0 0 0 4K29 Crystal structure of an enoyl-CoA hydratase/isomerase from Xanthobacter autotrophicus Py2 2013-04-08 2013-04-24 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of an enoyl-CoA hydratase/isomerase from Xanthobacter autotrophicus Py2 TO BE PUBLISHED 0 0 0 0 4K2N Crystal structure of an enoyl-CoA hydratase/ carnithine racemase from Magnetospirillum magneticum 2013-04-09 2013-04-24 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of an enoyl-CoA hydratase/ carnithine racemase from Magnetospirillum magneticum To be Published 0 0 0 0 4K3W Crystal structure of an enoyl-CoA hydratase/isomerase from Marinobacter aquaeolei 2013-04-11 2013-04-24 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of an enoyl-CoA hydratase/isomerase from Marinobacter aquaeolei To be Published 0 0 0 0 4F1W 23685211 Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with Adenine 2012-05-07 2013-05-01 Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L. Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with Adenine Structure 2013 21 963 974 4F2P 23685211 Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A 2012-05-08 2013-05-01 Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L. Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A Structure 2013 21 963 974 4F2W 23685211 Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with methyl-thio-DADMe-Immucillin-A 2012-05-08 2013-05-01 Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L. Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with methyl-thio-DADMe-Immucillin-A Structure 2013 21 963 974 4F3C 23685211 Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A 2012-05-09 2013-05-01 Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L. Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A Structure 2013 21 963 974 4F3K 23685211 Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A 2012-05-09 2013-05-01 Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L. Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A Structure 2013 21 963 974 4HZL 23589879 Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein 2012-11-15 2013-05-01 Deng, L.,Zhong, L.,Struble, E.,Duan, H.,Ma, L.,Harman, C.,Yan, H.,Virata-Theimer, M.L.,Zhao, Z.,Feinstone, S.,Alter, H.,Zhang, P. Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus. Proc.Natl.Acad.Sci.USA 2013 110 7418 7422 4IUR 23636332 crystal structure of SHH1 SAWADEE domain in complex with H3K9me3 peptide 2013-01-21 2013-05-01 Law, J.A.,Du, J.,Hale, C.J.,Feng, S.,Krajewski, K.,Palanca, A.M.,Strahl, B.D.,Patel, D.J.,Jacobsen, S.E. Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature 2013 498 385 389 4J2H Crystal structure of a putative short-chain alcohol dehydrogenase from Sinorhizobium meliloti 1021 (Target NYSGRC-011708) 2013-02-04 2013-05-01 Sampathkumar, P.,Gizzi, A.,Ahmed, M.,Banu, N.,Bhosle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Fiser, A.,Glenn, A.S.,Hammonds, J.,Hillerich, B.,Khafizov, K.,Lafleur, J.,Love, J.D.,Stead, M.,Seidel, R.,Toro, R.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) Crystal structure of a putative short-chain alcohol dehydrogenase from Sinorhizobium meliloti 1021 (Target NYSGRC-011708) to be published 0 0 0 0 4JFC Crystal structure of a enoyl-CoA hydratase from Polaromonas sp. JS666 2013-02-28 2013-05-01 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a enoyl-CoA hydratase from Polaromonas sp. JS666 To be Published 0 0 0 0 4JHM Crystal structure of a putative mandelate racemase/muconate lactonizing enzyme from Pseudovibrio sp. 2013-03-05 2013-05-01 Hegde, R.P.,Toro, R.,Burley, S.K.,Almo, S.C.,Ramagopal, U.A.,New York Structural Genomics Research Consortium (NYSGRC) Crystal structure of a putative mandelate racemase/muconate lactonizing enzyme from Pseudovibrio sp. To be published 0 0 0 0 4JIF 23695561 Co-crystal structure of ICAP1 PTB domain in complex with a KRIT1 peptide 2013-03-05 2013-05-01 Liu, W.,Boggon, T.J. Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide. Acta Crystallogr.,Sect.F 2013 69 494 498 4JIF 23695561 Co-crystal structure of ICAP1 PTB domain in complex with a KRIT1 peptide 2013-03-05 2013-05-01 Liu, W.,Boggon, T.J. Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide. Acta Crystallogr.,Sect.F 2013 69 494 498 4JJ9 Crystal Structure of 5-carboxymethyl-2-hydroxymuconate delta-isomerase 2013-03-07 2013-05-01 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal Structure of 5-carboxymethyl-2-hydroxymuconate delta-isomerase To be Published 0 0 0 0 4JXN CRYSTAL STRUCTURE OF POLYPRENYL SYNTHASE ISP_B (TARGET EFI-509198) FROM Roseobacter denitrificans 2013-03-28 2013-05-01 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Zencheck, W.D.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Poulter, C.D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Isoprenoid Synthase Isp_B from Roseobacter Denitrificans To be Published 0 0 0 0 4K8C Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with ADP 2013-04-18 2013-05-01 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with ADP To be Published 0 0 0 0 4K8K Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 1-(4-methoxyphenyl)-1-cyclopropane and 2-aminoperimidine 2013-04-18 2013-05-01 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 1-(4-methoxyphenyl)-1-cyclopropane and 2-aminoperimidine To be Published 0 0 0 0 4K8P Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-ethylbenzyl alcohol 2013-04-18 2013-05-01 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-ethylbenzyl alcohol To be Published 0 0 0 0 4K8T Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with ethyl 3,4-diaminobenzoate 2013-04-18 2013-05-01 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with ethyl 3,4-diaminobenzoate To be Published 0 0 0 0 4I5J 23752926 PP2A PR70 Holoenzyme 2012-11-28 2013-05-08 Wlodarchak, N.,Guo, F.,Satyshur, K.A.,Jiang, L.,Jeffrey, P.D.,Sun, T.,Stanevich, V.,Mumby, M.C.,Xing, Y. Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res. 2013 23 931 946 4I5K 23752926 PP2A PR70 Holoenzyme model3_diCa_rcsb.pdb bppnat5_extend.mtz 2012-11-28 2013-05-08 Wlodarchak, N.,Guo, F.,Satyshur, K.A.,Jiang, L.,Jeffrey, P.D.,Sun, T.,Stanevich, V.,Mumby, M.C.,Xing, Y. Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res. 2013 23 931 946 4IF4 23650349 Crystal Structure of the Magnesium and beryllofluoride-activated VraR from Staphylococcus aureus 2012-12-14 2013-05-08 Leonard, P.G.,Golemi-Kotra, D.,Stock, A.M. Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation. Proc.Natl.Acad.Sci.USA 2013 110 8525 8530 4JC8 23840694 Crystal Structure of HOPS component Vps33 from Chaetomium thermophilum 2013-02-21 2013-05-08 Baker, R.W.,Jeffrey, P.D.,Hughson, F.M. Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16* Plos One 2013 8 0 0 4JVY 23630077 Structure of the STAR (signal transduction and activation of RNA) domain of GLD-1 bound to RNA 2013-03-26 2013-05-08 Teplova, M.,Hafner, M.,Teplov, D.,Essig, K.,Tuschl, T.,Patel, D.J. Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Genes Dev. 2013 27 928 940 4JWT Crystal structure of a putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Sulfurimonas denitrificans DSM 1251 (Target NYSGRC-029304 ) 2013-03-27 2013-05-08 Sampathkumar, P.,Gizzi, A.,Ahmed, M.,Banu, N.,Bhosle, R.,Bonanno, J.,Chamala, S.,Chowdhury, S.,Fiser, A.,Glenn, A.S.,Hammonds, J.,Hillerich, B.,Khafizov, K.,Lafleur, J.,Suarez, J.,Haapalainen, A.,Love, J.D.,Stead, M.,Seidel, R.,Toro, R.,Schramm, V.L.,Almo, S.C. Crystal structure of a putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Sulfurimonas denitrificans DSM 1251 To be Published 0 0 0 0 4K38 23650368 Native anSMEcpe with bound AdoMet and Kp18Cys peptide 2013-04-10 2013-05-08 Goldman, P.J.,Grove, T.L.,Sites, L.A.,McLaughlin, M.I.,Booker, S.J.,Drennan, C.L. X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proc.Natl.Acad.Sci.USA 2013 110 8519 8524 4KGE 23677204 Crystal structure of near-infrared fluorescent protein with an extended stokes shift, pH 4.5 2013-04-29 2013-05-08 Piatkevich, K.D.,Malashkevich, V.N.,Morozova, K.S.,Nemkovich, N.A.,Almo, S.C.,Verkhusha, V.V. Extended Stokes shift in fluorescent proteins: chromophore-protein interactions in a near-infrared TagRFP675 variant. Sci Rep 2013 3 1847 1847 4KGF 23677204 Crystal structure of near-infrared fluorescent protein with an extended stokes shift, ph 8.0 2013-04-29 2013-05-08 Piatkevich, K.D.,Malashkevich, V.N.,Morozova, K.S.,Nemkovich, N.A.,Almo, S.C.,Verkhusha, V.V. Extended Stokes shift in fluorescent proteins: chromophore-protein interactions in a near-infrared TagRFP675 variant. Sci Rep 2013 3 1847 1847 4K8V 23647843 Structure of cyclic GMP-AMP Synthase (cGAS) 2013-04-18 2013-05-15 Gao, P.,Ascano, M.,Wu, Y.,Barchet, W.,Gaffney, B.L.,Zillinger, T.,Serganov, A.A.,Liu, Y.,Jones, R.A.,Hartmann, G.,Tuschl, T.,Patel, D.J. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.) 2013 153 1094 1107 4K96 23647843 Structure of Binary Complex of cGAS with Bound dsDNA 2013-04-19 2013-05-15 Gao, P.,Ascano, M.,Wu, Y.,Barchet, W.,Gaffney, B.L.,Zillinger, T.,Serganov, A.A.,Liu, Y.,Jones, R.A.,Hartmann, G.,Tuschl, T.,Patel, D.J. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.) 2013 153 1094 1107 4KEF Structure of Cofilin Mutant (cof1-159p) 2013-04-25 2013-05-15 Kish-Trier, E.,Haarer, B.,Cingolani, G.,Amberg, D.C. Structure of Cofilin Mutant (cof1-159p) To be Published 0 0 0 0 4FX6 23030629 Crystal structure of the mutant V182A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 2012-07-02 2013-05-22 Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry 2012 51 8665 8678 4FXR 23030629 Crystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 2012-07-03 2013-05-22 Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry 2012 51 8665 8678 4K93 CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE 2013-04-19 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE To be Published 0 0 0 0 4K9C CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE and 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBOXYLIC ACID 2013-04-19 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N-(HYDROXYMETHYL)BENZAMIDE and 4-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-7-CARBOXYLIC ACID To be Published 0 0 0 0 4K9I CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with Norharmane 2013-04-19 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. CRYSTAL STRUCTURE OF probable sugar kinase protein from Rhizobium etli CFN 42 complexed with Norharmane To be Published 0 0 0 0 4KA0 Crystal structure of a putative thiol-disulfide oxidoreductase from Bacteroides vulgatus (target NYSGRC-011676), space group P21221 2013-04-21 2013-05-22 Vetting, M.W.,Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.D.,Bonanno, J.B.,Armstrong, R.N.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) Crystal structure of a putative thiol-disulfide oxidoreductase from Bacteroides vulgatus (target NYSGRC-011676), space group P21221 To be Published 0 0 0 0 4KAD Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N1-(2.3-dihydro-1H-inden-5-yl)acetam 2013-04-22 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with N1-(2.3-dihydro-1H-inden-5-yl)acetam To be Published 0 0 0 0 4KAH Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 4-bromo-1H-pyrazole 2013-04-22 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 4-bromo-1H-pyrazole To be Published 0 0 0 0 4KAL Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with quinoline-3-carboxylic acid 2013-04-22 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Seidel, R.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with quinoline-3-carboxylic acid To be Published 0 0 0 0 4KAN Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-(2,5-dimethyl-1,3-thiazol-4-yl)acetic acid 2013-04-22 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with 2-(2,5-dimethyl-1,3-thiazol-4-yl)acetic acid To be Published 0 0 0 0 4KBE Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with benzoguanamine 2013-04-23 2013-05-22 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium etli CFN 42 complexed with benzoguanamine To be Published 0 0 0 0 4KPK Crystal structure of a enoyl-CoA hydratase from Shewanella pealeana ATCC 700345 2013-05-13 2013-05-22 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a enoyl-CoA hydratase from Shewanella pealeana ATCC 700345 To be Published 0 0 0 0 4G6T 23204470 Structure of the HopA1-SchA Chaperone-Effector Complex 2012-07-19 2013-06-05 Janjusevic, R.,Quezada, C.M.,Small, J.,Stebbins, C.E. Structure of the HopA1(21-102)-ShcA chaperone-effector complex of Pseudomonas syringae reveals conservation of a virulence factor binding motif from animal to plant pathogens. J.Bacteriol. 2013 195 658 664 4IZB 23704947 Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA 2013-01-29 2013-06-05 Tan, D.,Crabb, W.M.,Whitman, W.B.,Tong, L. Crystal Structure of DmdD, a Crotonase Superfamily Enzyme That Catalyzes the Hydration and Hydrolysis of Methylthioacryloyl-CoA. Plos One 2013 8 0 0 4IZD 23704947 Crystal structure of DmdD E121A in complex with MMPA-CoA 2013-01-29 2013-06-05 Tan, D.,Crabb, W.M.,Whitman, W.B.,Tong, L. Crystal Structure of DmdD, a Crotonase Superfamily Enzyme That Catalyzes the Hydration and Hydrolysis of Methylthioacryloyl-CoA. Plos One 2013 8 0 0 4FH8 23891152 Crystal Structure of Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum 2012-06-05 2013-06-12 Nguyen, J.B.,Pool, C.D.,Wong, C.Y.,Treger, R.S.,Williams, D.L.,Cappello, M.,Lea, W.A.,Simeonov, A.,Vermeire, J.J.,Modis, Y. Peroxiredoxin-1 from the Human Hookworm Ancylostoma ceylanicum Forms a Stable Oxidized Decamer and Is Covalently Inhibited by Conoidin A. Chem.Biol. 2013 20 991 1001 4GBD 23050701 Crystal Structure Of Adenosine Deaminase From Pseudomonas Aeruginosa Pao1 with bound Zn and methylthio-coformycin 2012-07-27 2013-06-12 Guan, R.,Ho, M.C.,Frohlich, R.F.,Tyler, P.C.,Almo, S.C.,Schramm, V.L. Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. Biochemistry 2012 51 9094 9103 4GBD 23050701 Crystal Structure Of Adenosine Deaminase From Pseudomonas Aeruginosa Pao1 with bound Zn and methylthio-coformycin 2012-07-27 2013-06-12 Guan, R.,Ho, M.C.,Frohlich, R.F.,Tyler, P.C.,Almo, S.C.,Schramm, V.L. Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. Biochemistry 2012 51 9094 9103 4JTA 23705070 Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin 2013-03-23 2013-06-12 Banerjee, A.,Lee, A.,Campbell, E.,Mackinnon, R. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife 2013 2 0 0 4JTC 23705070 Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+ 2013-03-23 2013-06-12 Banerjee, A.,Lee, A.,Campbell, E.,Mackinnon, R. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife 2013 2 0 0 4JTD 23705070 Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of Charybdotoxin 2013-03-23 2013-06-12 Banerjee, A.,Lee, A.,Campbell, E.,Mackinnon, R. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife 2013 2 0 0 4KIN 23746475 Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE 2013-05-02 2013-06-12 Wrobleski, S.T.,Lin, S.,Murali Dhar, T.G.,Dyckman, A.J.,Li, T.,Pitt, S.,Zhang, R.,Fan, Y.,Doweyko, A.M.,Tokarski, J.S.,Kish, K.F.,Kiefer, S.E.,Sack, J.S.,Newitt, J.A.,Witmer, M.R.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K. The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett. 2013 23 4120 4126 4KIP 23746475 Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE 2013-05-02 2013-06-12 Wrobleski, S.T.,Lin, S.,Murali Dhar, T.G.,Dyckman, A.J.,Li, T.,Pitt, S.,Zhang, R.,Fan, Y.,Doweyko, A.M.,Tokarski, J.S.,Kish, K.F.,Kiefer, S.E.,Sack, J.S.,Newitt, J.A.,Witmer, M.R.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K. The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett. 2013 23 4120 4126 4KKN Crystal structure of bovine CTLA-4, PSI-NYSGRC-012704 2013-05-06 2013-06-12 Kumar, P.R.,Casadevall, A.,Almo, S.C. Crystal structure of bovine CTLA-4, PSI-NYSGRC-012704 to be published 0 0 0 0 4FX8 23030629 Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 2012-07-02 2013-06-19 Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry 2012 51 8665 8678 4GC4 23030629 Crystal structure of the mutant R160A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 2012-07-29 2013-06-19 Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry 2012 51 8665 8678 4KRE 23746446 Structure of Human Argonaute-1 bound to endogenous Sf9 RNA 2013-05-16 2013-06-19 Faehnle, C.R.,Elkayam, E.,Haase, A.D.,Hannon, G.J.,Joshua-Tor, L. The making of a slicer: activation of human argonaute-1. Cell Rep 2013 3 1901 1909 4KMO 23840694 Crystal Structure of the Vps33-Vps16 HOPS subcomplex from Chaetomium thermophilum 2013-05-08 2013-06-26 Baker, R.W.,Jeffrey, P.D.,Hughson, F.M. Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16* Plos One 2013 8 0 0 4KNC 23779107 Structural and functional characterization of Pseudomonas aeruginosa AlgX 2013-05-09 2013-06-26 Riley, L.M.,Weadge, J.T.,Baker, P.,Robinson, H.,Codee, J.D.,Tipton, P.A.,Ohman, D.E.,Howell, P.L. Structural and Functional Characterization of Pseudomonas aeruginosa AlgX: ROLE OF AlgX IN ALGINATE ACETYLATION. J.Biol.Chem. 2013 288 22299 22314 4KNC 23779107 Structural and functional characterization of Pseudomonas aeruginosa AlgX 2013-05-09 2013-06-26 Riley, L.M.,Weadge, J.T.,Baker, P.,Robinson, H.,Codee, J.D.,Tipton, P.A.,Ohman, D.E.,Howell, P.L. Structural and Functional Characterization of Pseudomonas aeruginosa AlgX: ROLE OF AlgX IN ALGINATE ACETYLATION. J.Biol.Chem. 2013 288 22299 22314 4KNC 23779107 Structural and functional characterization of Pseudomonas aeruginosa AlgX 2013-05-09 2013-06-26 Riley, L.M.,Weadge, J.T.,Baker, P.,Robinson, H.,Codee, J.D.,Tipton, P.A.,Ohman, D.E.,Howell, P.L. Structural and Functional Characterization of Pseudomonas aeruginosa AlgX: ROLE OF AlgX IN ALGINATE ACETYLATION. J.Biol.Chem. 2013 288 22299 22314 4LBG Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with adenosine 2013-06-20 2013-07-03 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with adenosine To be Published 0 0 0 0 4LBX Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with cytidine 2013-06-21 2013-07-03 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with cytidine To be Published 0 0 0 0 4LC4 Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with guanosine 2013-06-21 2013-07-03 Malashkevich, v.n.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with guanosine To be Published 0 0 0 0 4LC6 Crystal structure of the mutant H128Q of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 2013-06-21 2013-07-03 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of the mutant H128Q of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP To be Published 0 0 0 0 4LC8 Crystal structure of the mutant H128N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 2013-06-21 2013-07-03 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of the mutant H128N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP To be Published 0 0 0 0 4LCA Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with thymidine 2013-06-21 2013-07-03 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of probable sugar kinase protein from Rhizobium Etli CFN 42 complexed with thymidine To be Published 0 0 0 0 3VZ0 23500184 Structural insights into cofactor and substrate selection by Gox0499 2012-10-09 2013-07-10 Yuan, Z.,Yin, B.,Wei, D.,Yuan, Y.A. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase J.Struct.Biol. 2013 182 125 135 3VZ3 23500184 Structural insights into substrate and cofactor selection by sp2771 2012-10-09 2013-07-10 Yuan, Z.,Yin, B.,Wei, D.,Yuan, Y.A. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase J.Struct.Biol. 2013 182 125 135 4GC5 23804760 Crystal structure of murine TFB1M 2012-07-29 2013-07-10 Guja, K.E.,Venkataraman, K.,Yakubovskaya, E.,Shi, H.,Mejia, E.,Hambardjieva, E.,Karzai, A.W.,Garcia-Diaz, M. Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1. 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J.Biol.Chem. 2013 288 24000 24011 4K9Z Crystal structure of a putative thiol-disulfide oxidoreductase from Bacteroides vulgatus (target NYSGRC-011676), space group P6222 2013-04-21 2013-07-10 Vetting, M.W.,Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.D.,Bonanno, J.B.,Armstrong, R.N.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) Crystal structure of a putative thiol-disulfide oxidoreductase from Bacteroides vulgatus (target NYSGRC-011676), space group P6222 To be Published 0 0 0 0 4KGQ 25087510 Crystal structure of a human light loop mutant in complex with dcr3 2013-04-29 2013-07-10 Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C. Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure 2014 22 1252 1262 4L8R 23329046 Structure of mrna stem-loop, human stem-loop binding protein and 3'hexo ternary complex 2013-06-17 2013-07-10 Tan, D.,Marzluff, W.F.,Dominski, Z.,Tong, L. Structure of Histone Mrna Stem-Loop, Human Stem-Loop Binding Protein, and 3'Hexo Ternary Complex. Science 2013 339 318 0 4LFE Crystal structure of geranylgeranyl diphosphate synthase sub1274 (target efi-509455) from streptococcus uberis 0140j with bound magnesium and isopentyl diphosphate, partially liganded complex; 2013-06-26 2013-07-10 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Poulter, C.D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Geranylgeranyl Diphosphate Synthase from Streptococcus Uberis 0140J To be Published 0 0 0 0 4LFG Crystal structure of geranylgeranyl diphosphate synthase sub1274 (target efi-509455) from streptococcus uberis 0140j with bound magnesium and isopentyl diphosphate, fully liganded complex; 2013-06-26 2013-07-10 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Poulter, C.D.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Geranylgeranyl Diphosphate Synthase from Streptococcus Uberis 0140J To be Published 0 0 0 0 4IOP 23803857 Crystal structure of NKp65 bound to its ligand KACL 2013-01-08 2013-07-17 Li, Y.,Wang, Q.,Chen, S.,Brown, P.H.,Mariuzza, R.A. Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. Proc.Natl.Acad.Sci.USA 2013 110 11505 11510 4K80 23863933 Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 2:0 ceramide-1-phosphate (2:0-C1P) 2013-04-17 2013-07-17 Simanshu, D.K.,Kamlekar, R.K.,Wijesinghe, D.S.,Zou, X.,Zhai, X.,Mishra, S.K.,Molotkovsky, J.G.,Malinina, L.,Hinchcliffe, E.H.,Chalfant, C.E.,Brown, R.E.,Patel, D.J. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 2013 500 463 467 4K85 23863933 Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 12:0 Ceramide-1-Phosphate (12:0-C1P) 2013-04-17 2013-07-17 Simanshu, D.K.,Kamlekar, R.K.,Wijesinghe, D.S.,Zou, X.,Zhai, X.,Mishra, S.K.,Molotkovsky, J.G.,Malinina, L.,Hinchcliffe, E.H.,Chalfant, C.E.,Brown, R.E.,Patel, D.J. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 2013 500 463 467 4KF6 23863933 Crystal structure of human ceramide-1-phosphate transfer protein (CPTP) in complex with 8:0 Ceramide-1-Phosphate (8:0-C1P) 2013-04-26 2013-07-17 Simanshu, D.K.,Kamlekar, R.K.,Wijesinghe, D.S.,Zou, X.,Zhai, X.,Mishra, S.K.,Molotkovsky, J.G.,Malinina, L.,Hinchcliffe, E.H.,Chalfant, C.E.,Brown, R.E.,Patel, D.J. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 2013 500 463 467 4KD6 Crystal structure of a Enoyl-CoA hydratase/isomerase from Burkholderia graminis C4D1M 2013-04-24 2013-07-24 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a Enoyl-CoA hydratase/isomerase from Burkholderia graminis C4D1M To be Published 0 0 0 0 4KPB 23829560 Crystal structure of cytochrome P450 BM-3 R47E mutant 2013-05-13 2013-07-24 Catalano, J.,Sadre-Bazzaz, K.,Amodeo, G.A.,Tong, L.,McDermott, A. Structural Evidence: A Single Charged Residue Affects Substrate Binding in Cytochrome P450 BM-3. Biochemistry 2013 52 6807 6815 4LK5 Crystal structure of a enoyl-CoA hydratase from Mycobacterium avium subsp. paratuberculosis K-10 2013-07-06 2013-07-24 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a enoyl-CoA hydratase from Mycobacterium avium subsp. paratuberculosis K-10 To be Published 0 0 0 0 4LKB Crystal structure of a putative 4-Oxalocrotonate Tautomerase from Nostoc sp. PCC 7120 2013-07-07 2013-07-24 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a putative 4-Oxalocrotonate Tautomerase from Nostoc sp. PCC 7120 To be Published 0 0 0 0 4LKR Crystal structure of deoD-3 gene product from Shewanella oneidensis MR-1, NYSGRC target 029437 2013-07-08 2013-07-24 Malashkevich, V.N.,Bonanno, J.B.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Almo, S.C. Crystal structure of deoD-3 gene product from Shewanella oneidensis MR-1, NYSGRC target 029437 To be Published 0 0 0 0 4LN1 CRYSTAL STRUCTURE OF L-lactate dehydrogenase from Bacillus cereus ATCC 14579 complexed with calcium, NYSGRC Target 029452 2013-07-11 2013-07-24 Malashkevich, V.N.,Bonanno, J.B.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Almo, S.C. Crystal structure of L-lactate dehydrogenase from Bacillus cereus ATCC 14579 complexed with calcium, NYSGRC Target 029452 To be Published 0 0 0 0 4LNA CRYSTAL STRUCTURE OF purine nucleoside phosphorylase I from Spirosoma linguale DSM 74, NYSGRC Target 029362 2013-07-11 2013-07-24 Malashkevich, V.N.,Bonanno, J.B.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Almo, S.C. Crystal structure of purine nucleoside phosphorylase I from Spirosoma linguale DSM 74, NYSGRC Target 029362 To be Published 0 0 0 0 4LNH Crystal structure of uridine phosphorylase from Vibrio fischeri ES114, NYSGRC Target 29520. 2013-07-11 2013-07-24 Malashkevich, V.N.,Bonanno, J.B.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Almo, S.C. Crystal structure of uridine phosphorylase from Vibrio fischeri ES114, NYSGRC Target 29520. To be Published 0 0 0 0 4GD6 23145056 SHV-1 beta-lactamase in complex with penam sulfone SA1-204 2012-07-31 2013-07-31 Ke, W.,Pattanaik, P.,Bethel, C.R.,Sheri, A.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F. Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation Plos One 2012 7 0 0 4KVO 23912279 The NatA (Naa10p/Naa15p) amino-terminal acetyltrasferase complex bound to AcCoA 2013-05-22 2013-07-31 Liszczak, G.,Goldberg, J.M.,Foyn, H.,Petersson, E.J.,Arnesen, T.,Marmorstein, R. Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat.Struct.Mol.Biol. 2013 20 1098 1105 4KVX 23912279 Crystal structure of Naa10 (Ard1) bound to AcCoA 2013-05-23 2013-07-31 Liszczak, G.,Goldberg, J.M.,Foyn, H.,Petersson, E.J.,Arnesen, T.,Marmorstein, R. Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat.Struct.Mol.Biol. 2013 20 1098 1105 4L5R 23850291 Crystal structure of p202 HIN1 in complex with 20-mer dsDNA 2013-06-11 2013-07-31 Yin, Q.,Sester, D.P.,Tian, Y.,Hsiao, Y.S.,Lu, A.,Cridland, J.A.,Sagulenko, V.,Thygesen, S.J.,Choubey, D.,Hornung, V.,Walz, T.,Stacey, K.J.,Wu, H. Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Rep 2013 4 327 339 4LMR Crystal structure of L-lactate dehydrogenase from Bacillus cereus ATCC 14579, NYSGRC Target 029452 2013-07-10 2013-07-31 Malashkevich, V.N.,Bonanno, J.B.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Khafizov, K.,Seidel, R.,Almo, S.C. Crystal structure of L-lactate dehydrogenase from Bacillus cereus ATCC 14579, NYSGRC Target 029452 To be Published 0 0 0 0 4AZO 24531463 Murine epidermal fatty acid-binding protein (FABP5), apo form, poly- his tag removed 2012-06-26 2013-08-07 Sanson, B.,Wang, T.,Sun, J.,Wang, L.,Kaczocha, M.,Ojima, I.,Deutsch, D.,Li, H. Crystallographic Study of Fabp5 as an Intracellular Endocannabinoid Transporter. Acta Crystallogr.,Sect.D 2014 70 290 0 4AZP 24531463 Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid anandamide 2012-06-26 2013-08-07 Sanson, B.,Wang, T.,Sun, J.,Wang, L.,Kaczocha, M.,Ojima, I.,Deutsch, D.,Li, H. Crystallographic Study of Fabp5 as an Intracellular Endocannabinoid Transporter. Acta Crystallogr.,Sect.D 2014 70 290 0 4HRS 23821306 Crystal structure of H. volcanii small archaeal modifier protein 2 2012-10-28 2013-08-07 Li, Y.,Maciejewski, M.W.,Martin, J.,Jin, K.,Zhang, Y.,Maupin-Furlow, J.A.,Hao, B. Crystal structure of the ubiquitin-like small archaeal modifier protein 2 from Haloferax volcanii. Protein Sci. 2013 22 1206 1217 4KDZ Crystal structure of tRNA/rRNA methyltransferase YibK from Escherichia coli (Target NYSGRC-012599) 2013-04-25 2013-08-07 Kim, J.,Toro, R.,Bhosle, R.,Almo, S.C. Crystal structure of tRNA/rRNA methyltransferase YibK from Escherichia coli (Target NYSGRC-012599) To be Published 0 0 0 0 4KG8 25087510 Crystal structure of light mutant 2013-04-28 2013-08-07 Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C. Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure 2014 22 1252 1262 4KGG 25087510 Crystal structure of light mutant2 and dcr3 complex 2013-04-29 2013-08-07 Liu, W.,Zhan, C.,Cheng, H.,Kumar, P.R.,Bonanno, J.B.,Nathenson, S.G.,Almo, S.C. Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure 2014 22 1252 1262 4LUI Crystal structure of Orotidine 5'-monophosphate decarboxylase from methanocaldococcus jannaschii 2013-07-25 2013-08-07 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of Orotidine 5'-monophosphate decarboxylase from methanocaldococcus jannaschii To be Published 0 0 0 0 4LUJ Crystal structure of Orotidine 5'-monophosphate decarboxylase from methanocaldococcus jannaschii complexed with inhibitor BMP 2013-07-25 2013-08-07 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of Orotidine 5'-monophosphate decarboxylase from methanocaldococcus jannaschii complexed with inhibitor BMP To be Published 0 0 0 0 4AZQ 24531463 Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid 2-arachidonoylglycerol 2012-06-26 2013-08-14 Sanson, B.,Wang, T.,Sun, J.,Wang, L.,Kaczocha, M.,Ojima, I.,Deutsch, D.,Li, H. Crystallographic Study of Fabp5 as an Intracellular Endocannabinoid Transporter. Acta Crystallogr.,Sect.D 2014 70 290 0 4KUX 23905850 Crystal structure of Aspergillus terreus aristolochene synthase complexed with farnesyl thiolodiphosphate (FSPP) 2013-05-22 2013-08-14 Chen, M.,Al-Lami, N.,Janvier, M.,D'Antonio, E.L.,Faraldos, J.A.,Cane, D.E.,Allemann, R.K.,Christianson, D.W. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry 2013 52 5441 5453 4KVI 23905850 Crystal structure of Aspergillus terreus aristolochene synthase complexed with (4aS,7S)-4a-methyl-7-(prop-1-en-2-yl)-2,3,4,4a,5,6,7,8-octahydroquinolin-1-ium 2013-05-22 2013-08-14 Chen, M.,Al-Lami, N.,Janvier, M.,D'Antonio, E.L.,Faraldos, J.A.,Cane, D.E.,Allemann, R.K.,Christianson, D.W. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry 2013 52 5441 5453 4KVW 23905850 Crystal structure of Aspergillus terreus aristolochene synthase complexed with (3R,6R,9aR)-6,9a-dimethyl-3-(prop-1-en-2-yl)decahydroquinolizin-5-ium 2013-05-23 2013-08-14 Chen, M.,Al-Lami, N.,Janvier, M.,D'Antonio, E.L.,Faraldos, J.A.,Cane, D.E.,Allemann, R.K.,Christianson, D.W. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry 2013 52 5441 5453 4KVY 23905850 Crystal structure of Aspergillus terreus aristolochene synthase complexed with (1S,8S,9aR)-1,9a-dimethyl-8-(prop-1-en-2-yl)decahydroquinolizin-5-ium 2013-05-23 2013-08-14 Chen, M.,Al-Lami, N.,Janvier, M.,D'Antonio, E.L.,Faraldos, J.A.,Cane, D.E.,Allemann, R.K.,Christianson, D.W. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry 2013 52 5441 5453 4KWD 23905850 Crystal structure of Aspergillus terreus aristolochene synthase complexed with (1R,8R,9aS)-1,9a-dimethyl-8-(prop-1-en-2-yl)decahydroquinolizin-5-ium 2013-05-23 2013-08-14 Chen, M.,Al-Lami, N.,Janvier, M.,D'Antonio, E.L.,Faraldos, J.A.,Cane, D.E.,Allemann, R.K.,Christianson, D.W. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry 2013 52 5441 5453 4L5S 23850291 p202 HIN1 in complex with 12-mer dsDNA 2013-06-11 2013-08-14 Yin, Q.,Sester, D.P.,Tian, Y.,Hsiao, Y.S.,Lu, A.,Cridland, J.A.,Sagulenko, V.,Thygesen, S.J.,Choubey, D.,Hornung, V.,Walz, T.,Stacey, K.J.,Wu, H. Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Rep 2013 4 327 339 4LOH 23910378 Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(3',5')p] 2013-07-12 2013-08-14 Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell(Cambridge,Mass.) 2013 154 748 762 4LOI 23910378 Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(2',5')p] 2013-07-12 2013-08-14 Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell(Cambridge,Mass.) 2013 154 748 762 4LOJ 23910378 Crystal structure of mSting in complex with c[G(2',5')pA(3',5')p] 2013-07-12 2013-08-14 Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell(Cambridge,Mass.) 2013 154 748 762 4LOK 23910378 Crystal structure of mSting in complex with c[G(3',5')pA(3',5')p] 2013-07-12 2013-08-14 Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell(Cambridge,Mass.) 2013 154 748 762 4M1A Crystal structure of a Domain of unknown function (DUF1904) from Sebaldella termitidis ATCC 33386 2013-08-02 2013-08-14 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a Domain of unknown function (DUF1904) from Sebaldellatermitidis ATCC 33386 To be Published 0 0 0 0 4HQB 23975200 Crystal structure of DdrB from Deinococcus radiodurans bound to ssDNA 2012-10-25 2013-09-04 Sugiman-Marangos, S.N.,Peel, J.K.,Weiss, Y.M.,Ghirlando, R.,Junop, M.S. Crystal structure of the DdrB/ssDNA complex from Deinococcus radiodurans reveals a DNA binding surface involving higher-order oligomeric states. Nucleic Acids Res. 2013 41 9934 9944 4JH0 23964740 Crystal structure of dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) (DPP-IV-WT) complex with bms-767778 AKA 2-(3-(aminomethyl)-4-(2,4- dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6h-pyrrolo[3,4- b]pyridin-6-yl)-n,n-dimethylacetamide 2013-03-04 2013-09-04 Devasthale, P.,Wang, Y.,Wang, W.,Fevig, J.,Feng, J.,Wang, A.,Harrity, T.,Egan, D.,Morgan, N.,Cap, M.,Fura, A.,Klei, H.E.,Kish, K.,Weigelt, C.,Sun, L.,Levesque, P.,Moulin, F.,Li, Y.X.,Zahler, R.,Kirby, M.S.,Hamann, L.G. Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). J.Med.Chem. 2013 56 7343 7357 4LKO 23964740 Crystal structure of human DPP-IV in complex with BMS-744891 2013-07-08 2013-09-04 Devasthale, P.,Wang, Y.,Wang, W.,Fevig, J.,Feng, J.,Wang, A.,Harrity, T.,Egan, D.,Morgan, N.,Cap, M.,Fura, A.,Klei, H.E.,Kish, K.,Weigelt, C.,Sun, L.,Levesque, P.,Moulin, F.,Li, Y.X.,Zahler, R.,Kirby, M.S.,Hamann, L.G. Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). J.Med.Chem. 2013 56 7343 7357 4M51 23972005 Crystal structure of amidohydrolase nis_0429 (ser145ala mutant) from nitratiruptor sp. sb155-2 2013-08-07 2013-09-04 Goble, A.M.,Toro, R.,Li, X.,Ornelas, A.,Fan, H.,Eswaramoorthy, S.,Patskovsky, Y.,Hillerich, B.,Seidel, R.,Sali, A.,Shoichet, B.K.,Almo, S.C.,Swaminathan, S.,Tanner, M.E.,Raushel, F.M. Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes. Biochemistry 2013 52 6525 6536 4MB6 Crystal structure of adenine phosphoribosyltransferase from Yersinia pseudotuberculosis. 2013-08-19 2013-09-04 Pavithra, G.C.,Kim, J.,Hegde, R.P.,Almo, S.C.,Ramagopal, U.A. Crystal structure of adenine phosphoribosyltransferase from Yersinia pseudotuberculosis To be published 0 0 0 0 4HU8 23794438 Crystal Structure of a Bacterial Ig-like Domain Containing GH10 Xylanase from Termite Gut 2012-11-02 2013-09-18 Han, Q.,Liu, N.,Robinson, H.,Cao, L.,Qian, C.,Wang, Q.,Xie, L.,Ding, H.,Wang, Q.,Huang, Y.,Li, J.,Zhou, Z. Biochemical characterization and crystal structure of a GH10 xylanase from termite gut bacteria reveal a novel structural feature and significance of its bacterial Ig-like domain. Biotechnol.Bioeng. 2013 110 3093 3103 4MMW Crystal structure of D-glucarate dehydratase from Agrobacterium tumefaciens complexed with magnesium, L-Xylarohydroxamate and L-Lyxarohydroxamate 2013-09-09 2013-09-18 Fedorov, A.A.,Fedorov, E.V.,Sakai, A.,Gerlt, J.A.,Almo, S.C. Crystal structure of D-glucarate dehydratase from Agrobacterium tumefaciens complexed with magnesium, L-Xylarohydroxamate and L-Lyxarohydroxamate To be Published 0 0 0 0 4MHC 24062435 Crystal Structure of a Nucleoporin 2013-08-29 2013-09-25 Seo, H.S.,Blus, B.J.,Jankovic, N.Z.,Blobel, G. Structure and nucleic acid binding activity of the nucleoporin Nup157. Proc.Natl.Acad.Sci.USA 2013 110 16450 16455 4MPF Crystal structure of human glutathione transferase theta-2, complex with inorganic phosphate, GSH free, target EFI-507257 2013-09-12 2013-09-25 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Human Glutathione S-Transferase Theta-2 (Target Efi-507257) To be Published 0 0 0 0 4MPG Crystal structure of human glutathione transferase theta-2, complex with glutathione and unknown ligand, target EFI-507257 2013-09-12 2013-09-25 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Human Glutathione S-Transferase Theta-2 (Target EFI-507257) To be Published 0 0 0 0 4LIX 24036329 Crystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate at 1.55 A resolution 2013-07-04 2013-10-02 Koksal, M.,Potter, K.,Peters, R.J.,Christianson, D.W. 1.55 angstrom -resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis. Biochim.Biophys.Acta 2013 1840 184 190 4MUZ Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus complexed with inhibitor BMP 2013-09-23 2013-10-02 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus complexed with inhibitor BMP To be Published 0 0 0 0 4I4C 23452154 Crystal structure of the protein frsA complexed with unknown ligand 2012-11-27 2013-10-09 Kellett, W.F.,Brunk, E.,Desai, B.J.,Fedorov, A.A.,Almo, S.C.,Gerlt, J.A.,Rothlisberger, U.,Richards, N.G. Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase. Biochemistry 2013 52 1842 1844 3VZ2 23500184 Structural insights into substrate and cofactor selection by sp2771 2012-10-09 2013-10-16 Yuan, Z.,Yin, B.,Wei, D.,Yuan, Y.R. Structural basis for cofactor and substrate selection by cyanobacterium succinic semialdehyde dehydrogenase J.Struct.Biol. 2013 182 125 135 4K9E 24127596 Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D 2013-04-19 2013-10-16 Reshetnyak, A.V.,Nelson, B.,Shi, X.,Boggon, T.J.,Pavlenco, A.,Mandel-Bausch, E.M.,Tome, F.,Suzuki, Y.,Sidhu, S.S.,Lax, I.,Schlessinger, J. Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proc.Natl.Acad.Sci.USA 2013 110 17832 17837 4M0E 24900610 Structure of human acetylcholinesterase in complex with dihydrotanshinone I 2013-08-01 2013-10-16 Cheung, J.,Gary, E.N.,Shiomi, K.,Rosenberry, T.L. Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS Med Chem Lett 2013 4 1091 1096 4M0F 24900610 Structure of human acetylcholinesterase in complex with territrem B 2013-08-01 2013-10-16 Cheung, J.,Gary, E.N.,Shiomi, K.,Rosenberry, T.L. Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS Med Chem Lett 2013 4 1091 1096 4MZW CRYSTAL STRUCTURE OF NU-CLASS GLUTATHIONE TRANSFERASE YGHU FROM Streptococcus sanguinis SK36, COMPLEX WITH GLUTATHIONE DISULFIDE, TARGET EFI-507286 2013-09-30 2013-10-16 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Glutathione S-Transferase Yghu (Target Efi-507286) To be Published 0 0 0 0 4FB3 24109229 Polyomavirus T-ag binds symmetrical repeats at the viral origin in an asymmetrical manner 2012-05-22 2013-10-23 Harrison, C.,Jiang, T.,Banerjee, P.,Meinke, G.,D'Abramo, C.M.,Schaffhausen, B.,Bohm, A. Polyomavirus large T antigen binds symmetrical repeats at the viral origin in an asymmetrical manner. J.Virol. 2013 87 13751 13759 4IS6 24108701 Crystal structure of HLA-DR4 bound to GP100 peptide 2013-01-16 2013-10-23 Chen, S.,Li, Y.,Depontieu, F.R.,McMiller, T.L.,English, A.M.,Shabanowitz, J.,Kos, F.,Sidney, J.,Sette, A.,Rosenberg, S.A.,Hunt, D.F.,Mariuzza, R.A.,Topalian, S.L. Structure-Based Design of Altered MHC Class II-Restricted Peptide Ligands with Heterogeneous Immunogenicity. J.Immunol. 2013 191 5097 5106 4N4U 25540822 Crystal structure of ABC transporter solute binding protein BB0719 from Bordetella bronchiseptica RB50, TARGET EFI-510049 2013-10-08 2013-10-23 Vetting, M.W.,Al-Obaidi, N.,Zhao, S.,San Francisco, B.,Kim, J.,Wichelecki, D.J.,Bouvier, J.T.,Solbiati, J.O.,Vu, H.,Zhang, X.,Rodionov, D.A.,Love, J.D.,Hillerich, B.S.,Seidel, R.D.,Quinn, R.J.,Osterman, A.L.,Cronan, J.E.,Jacobson, M.P.,Gerlt, J.A.,Almo, S.C. Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry 2015 54 909 931 4HRO Crystal structure of H. volcanii small archaeal modifier protein 1 2012-10-28 2013-10-30 Li, Y.,Maciejewski, M.W.,Jin, K.,Martin, J.,Zhang, Y.,Lu, M.,Maupin-Furlow, J.A.,Hao, B. Crystal structure of H. volcanii small archaeal modifier protein 1 To be Published 0 0 0 0 4JLF 24060876 Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase 2013-03-12 2013-10-30 Kurz, S.G.,Wolff, K.A.,Hazra, S.,Bethel, C.R.,Hujer, A.M.,Smith, K.M.,Xu, Y.,Tremblay, L.W.,Blanchard, J.S.,Nguyen, L.,Bonomo, R.A. Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob.Agents Chemother. 2013 57 6085 6096 4M65 In situ thermolysin crystallized on a MiTeGen micromesh with asparagine ligand 2013-08-08 2013-10-30 Yin, X.,Scalia, A.,Leroy, L.,Cuttitta, C.M.,Polizzo, G.M.,Ericson, D.L.,Roessler, C.G.,Campos, O.,Agarwal, R.,Allaire, M.,Orville, A.M.,Jackimowicz, R.,Ma, M.Y.,Sweet, R.M.,Soares, A.S. Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes Acta Crystallogr.,Sect.D 0 0 1177 1189 4N2Y Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus 2013-10-06 2013-10-30 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus To be Published 0 0 0 0 4N5U Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240] 2013-10-10 2013-10-30 Kumar, P.R.,Casadevall, A.,Almo, S.C. Crystal structure of the 4th FN3 domain of human PTP, receptor F [PSI-NYSGRC-006240] to be published 0 0 0 0 4N68 Crystal structure of an internal FN3 domain from human Contactin-5 [PSI-NYSGRC-005804] 2013-10-11 2013-10-30 Kumar, P.R.,Casadevall, A.,Almo, S.C. Crystal structure of an internal FN3 domain from human Contactin-5 [PSI-NYSGRC-005804] to be published 0 0 0 0 4N8P Crystal structure of a strand swapped CTLA-4 from Duckbill Platypus [PSI-NYSGRC-012711] 2013-10-17 2013-10-30 Kumar, P.R.,Casadevall, A.,Almo, S.C. Crystal structure of a strand swapped CTLA-4 from Duckbill Platypus [PSI-NYSGRC-012711] to be published 0 0 0 0 4N8Z 24816088 In situ lysozyme crystallized on a MiTeGen micromesh with benzamidine ligand 2013-10-18 2013-10-30 Yin, X.,Scalia, A.,Leroy, L.,Cuttitta, C.M.,Polizzo, G.M.,Ericson, D.L.,Roessler, C.G.,Campos, O.,Ma, M.Y.,Agarwal, R.,Jackimowicz, R.,Allaire, M.,Orville, A.M.,Sweet, R.M.,Soares, A.S. Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes. Acta Crystallogr.,Sect.D 2014 70 1177 1189 4K2J 24146617 Decameric ring structure of KSHV (HHV-8) latency-associated nuclear antigen (LANA) DNA binding domain 2013-04-09 2013-11-06 Domsic, J.F.,Chen, H.S.,Lu, F.,Marmorstein, R.,Lieberman, P.M. Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA. Plos Pathog. 2013 9 0 0 4MFB 24151856 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor 2013-08-27 2013-11-06 Lee, W.G.,Gallardo-Macias, R.,Frey, K.M.,Spasov, K.A.,Bollini, M.,Anderson, K.S.,Jorgensen, W.L. Picomolar Inhibitors of HIV Reverse Transcriptase Featuring Bicyclic Replacement of a Cyanovinylphenyl Group. J.Am.Chem.Soc. 2013 135 16705 16713 4NAX Crystal structure of glutathione transferase PPUT_1760 from Pseudomonas putida, target EFI-507288, with one glutathione disulfide bound per one protein subunit 2013-10-22 2013-11-06 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of glutathione transferase Pput_1760 from Pseudomonas putida, target EFI-507288 To be Published 0 0 0 0 4CDP 17023414 Improved coordinates for Escherichia coli O157:H7 heme degrading enzyme ChuS. 2013-11-05 2013-11-13 Suits, M.D.,Jaffer, N.,Jia, Z. Structure of the Escherichia Coli O157:H7 Heme Oxygenase Chus in Complex with Heme and Enzymatic Inactivation by Mutation of the Heme Coordinating Residue His-193. J.Biol.Chem. 2006 281 36776 0 4ILW 24073280 Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2) 2013-01-01 2013-11-13 Batra, J.,Soares, A.S.,Mehner, C.,Radisky, E.S. Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes. Plos One 2013 8 0 0 4KOO 24192350 Crystal Structure of WHY1 from Arabidopsis thaliana 2013-05-12 2013-11-13 Cappadocia, L.,Parent, J.S.,Sygusch, J.,Brisson, N. A family portrait: structural comparison of the Whirly proteins from Arabidopsis thaliana and Solanum tuberosum. Acta Crystallogr.,Sect.F 2013 69 1207 1211 4KOP 24192350 Crystal Structure of WHY2 from Arabidopsis thaliana 2013-05-12 2013-11-13 Cappadocia, L.,Parent, J.S.,Sygusch, J.,Brisson, N. A family portrait: structural comparison of the Whirly proteins from Arabidopsis thaliana and Solanum tuberosum. Acta Crystallogr.,Sect.F 2013 69 1207 1211 4KOQ 24192350 Crystal Structure of WHY3 from Arabidopsis thaliana 2013-05-12 2013-11-13 Cappadocia, L.,Parent, J.S.,Sygusch, J.,Brisson, N. A family portrait: structural comparison of the Whirly proteins from Arabidopsis thaliana and Solanum tuberosum. Acta Crystallogr.,Sect.F 2013 69 1207 1211 4L6D Crystal structure of 5-carboxyvanillate decarboxylase from Sphingomonas paucimobilis complexed with vanillic acid 2013-06-12 2013-11-13 Fedorov, A.A.,Fedorov, E.V.,Vladimirova, A.,Raushel, F.M.,Almo, S.C. Crystal structure of 5-carboxyvanillate decarboxylase from Sphingomonas paucimobilis complexed with vanillic acid To be Published 0 0 0 0 4LK0 24218560 Crystal Structure Analysis of the E.coli holoenzyme/T7 Gp2 complex 2013-07-05 2013-11-13 Bae, B.,Davis, E.,Brown, D.,Campbell, E.A.,Wigneshweraraj, S.,Darst, S.A. Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA 2013 110 19772 19777 4LK1 24218560 Crystal Structure Analysis of the E.coli holoenzyme 2013-07-05 2013-11-13 Bae, B.,Davis, E.,Brown, D.,Campbell, E.A.,Wigneshweraraj, S.,Darst, S.A. Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA 2013 110 19772 19777 4LLG 24218560 Crystal Structure Analysis of the E.coli holoenzyme/Gp2 complex 2013-07-09 2013-11-13 Bae, B.,Davis, E.,Brown, D.,Campbell, E.A.,Wigneshweraraj, S.,Darst, S.A. Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA 2013 110 19772 19777 4NG3 Crystal structure of 5-carboxyvanillate decarboxylase from Sphingomonas paucimobilis complexed with 4-Hydroxy-3-methoxy-5-nitrobenzoic acid 2013-11-01 2013-11-13 Fedorov, A.A.,Fedorov, E.V.,Vladimirova, A.,Raushel, F.M.,Almo, S.C. Crystal structure of 5-carboxyvanillate decarboxylase from Sphingomonas paucimobilis complexed with 4-Hydroxy-3-methoxy-5-nitrobenzoic acid To be Published 0 0 0 0 4NHW Crystal structure of glutathione transferase SMc00097 from Sinorhizobium meliloti, target EFI-507275, with one glutathione bound per one protein subunit 2013-11-05 2013-11-20 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of glutathione transferase SMc00097 from Sinorhizobium meliloti, target EFI-507275 To be Published 0 0 0 0 4NHZ Crystal structure of glutathione transferase BBTA-3750 from Bradyrhizobium sp., Target EFI-507290, with one glutathione bound 2013-11-05 2013-11-20 Patskovsky, Y.,Vetting, M.W.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Morisco, L.L.,Wasserman, S.R.,Sojitra, S.,Stead, M.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Hillerich, B.,Love, J.,Seidel, R.D.,Imker, H.J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C. Crystal Structure of Glutathione Transferase Bbta-3750 from Bradyrhizobium Sp., Target Efi-507290 To be Published 0 0 0 0 3W1Y Crystal structure of T brucei ATG8.2 in complex with E coli S10 2012-11-23 2013-11-27 Yuan, Y.A.,Wang, C. Crystal structure of T brucei ATG8.2 To be Published 0 0 0 0 4KGX 24138583 The R state structure of E. coli ATCase with CTP bound 2013-04-29 2013-11-27 Cockrell, G.M.,Zheng, Y.,Guo, W.,Peterson, A.W.,Truong, J.K.,Kantrowitz, E.R. New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase. Biochemistry 2013 52 8036 8047 4KGZ 24138583 The R state structure of E. coli ATCase with UTP and Magnesium bound 2013-04-29 2013-11-27 Cockrell, G.M.,Zheng, Y.,Guo, W.,Peterson, A.W.,Truong, J.K.,Kantrowitz, E.R. New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase. Biochemistry 2013 52 8036 8047 4KH0 24138583 The R state structure of E. coli ATCase with ATP and Magnesium bound 2013-04-29 2013-11-27 Cockrell, G.M.,Zheng, Y.,Guo, W.,Peterson, A.W.,Truong, J.K.,Kantrowitz, E.R. New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase. Biochemistry 2013 52 8036 8047 4MSV 27806260 Crystal structure of FASL and DcR3 complex 2013-09-18 2013-11-27 Liu, W.,Ramagopal, U.,Cheng, H.,Bonanno, J.B.,Toro, R.,Bhosle, R.,Zhan, C.,Almo, S.C. Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure 2016 24 2016 2023 4MYL 24261485 Crystal structure of Trypanosoma cruzi Formiminoglutamase (oxidized) at pH 4.6 2013-09-27 2013-11-27 Hai, Y.,Dugery, R.J.,Healy, D.,Christianson, D.W. Formiminoglutamase from trypanosoma cruzi is an arginase-like manganese metalloenzyme. Biochemistry 2013 52 9294 9309 4MYN 24261485 Crystal structure of Trypanosoma cruzi formiminoglutamase N114H variant with Mn2+2 2013-09-27 2013-11-27 Hai, Y.,Dugery, R.J.,Healy, D.,Christianson, D.W. Formiminoglutamase from trypanosoma cruzi is an arginase-like manganese metalloenzyme. Biochemistry 2013 52 9294 9309 4MZZ 24138653 Crystal structure of Bovine 3 Glu-Osteocalcin. 2013-09-30 2013-11-27 Malashkevich, V.N.,Almo, S.C.,Dowd, T.L. X-ray crystal structure of bovine 3 Glu-osteocalcin. Biochemistry 2013 52 8387 8392 3W9U Crystal structure of Lipk107 2013-04-17 2013-12-04 Yuan, Y.A. Crystal structure of Lipk107 To be Published 0 0 0 0 4LZZ 24240239 Nucleotide-induced asymmetry within atpase activator ring drives s54-RNAP interaction and ATP hydrolysis 2013-08-01 2013-12-04 Sysoeva, T.A.,Chowdhury, S.,Guo, L.,Nixon, B.T. Nucleotide-induced asymmetry within ATPase activator ring drives sigma 54-RNAP interaction and ATP hydrolysis. Genes Dev. 2013 27 2500 2511 4NOF Crystal structure of the second Ig domain from mouse Polymeric Immunoglobulin receptor [PSI-NYSGRC-006220] 2013-11-19 2013-12-04 Sampathkumar, P.,Casadevall, A.,Almo, S.C. Crystal structure of the second Ig domain from mouse Polymeric Immunoglobulin receptor to be published 0 0 0 0 4ICM Crystal structure of 5-carboxyvanillate decarboxylase LigW from Sphingomonas paucimobilis 2012-12-10 2013-12-11 Fedorov, A.A.,Fedorov, E.V.,Vladimirova, A.,Raushel, F.M.,Almo, S.C. Crystal structure of 5-carboxyvanillate decarboxylase LigW from Sphingomonas paucimobilis To be Published 0 0 0 0 4M6D Crystal structure of the aptamer minF-lysozyme complex. 2013-08-09 2013-12-11 Malashkevich, V.N.,Padlan, F.C.,Toro, R.,Girvin, M.,Almo, S.C. Crystal structure of the aptamer minF-lysozyme complex. To be Published 0 0 0 0 4LTV 24517311 Crystal structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2) 2013-07-24 2013-12-18 Li, R.,Chou, W.K.,Himmelberger, J.A.,Litwin, K.M.,Harris, G.G.,Cane, D.E.,Christianson, D.W. Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase. Biochemistry 2014 53 1155 1168 4LUU 24517311 V329A Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium cation 2013-07-25 2013-12-18 Li, R.,Chou, W.K.,Himmelberger, J.A.,Litwin, K.M.,Harris, G.G.,Cane, D.E.,Christianson, D.W. Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase. Biochemistry 2014 53 1155 1168 4LXW 24517311 L72V Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium cation 2013-07-30 2013-12-18 Li, R.,Chou, W.K.,Himmelberger, J.A.,Litwin, K.M.,Harris, G.G.,Cane, D.E.,Christianson, D.W. Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase. Biochemistry 2014 53 1155 1168 4LZ3 24517311 F95H Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium cation 2013-07-31 2013-12-18 Li, R.,Chou, W.K.,Himmelberger, J.A.,Litwin, K.M.,Harris, G.G.,Cane, D.E.,Christianson, D.W. Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase. Biochemistry 2014 53 1155 1168 4M4O Crystal structure of the aptamer minE-lysozyme complex 2013-08-07 2013-12-18 Malashkevich, V.N.,Padlan, F.C.,Toro, R.,Girvin, M.,Almo, S.C. Crystal structure of the aptamer minE-lysozyme complex to be published 0 0 0 0 4MBB 24447265 Cubic crystal form of PIR1 dual specificity phosphatase core 2013-08-19 2013-12-18 Sankhala, R.S.,Lokareddy, R.K.,Cingolani, G. Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase. Biochemistry 2014 53 862 871 4NT0 Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate 2013-11-29 2013-12-18 Fedorov, A.A.,Fedorov, E.V.,Iiams, V.,Gerlt, J.A.,Almo, S.C. Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate To be Published 0 0 0 0 4LSL 24289305 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ476), a non-nucleoside inhibitor 2013-07-22 2013-12-25 Frey, K.M.,Gray, W.T.,Spasov, K.A.,Bollini, M.,Gallardo-Macias, R.,Jorgensen, W.L.,Anderson, K.S. Structure-Based Evaluation of C5 Derivatives in the Catechol Diether Series Targeting HIV-1 Reverse Transcriptase. Chem.Biol.Drug Des. 2014 83 541 549 4LSN 24289305 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ518), a non-nucleoside inhibitor 2013-07-22 2013-12-25 Frey, K.M.,Gray, W.T.,Spasov, K.A.,Bollini, M.,Gallardo-Macias, R.,Jorgensen, W.L.,Anderson, K.S. Structure-Based Evaluation of C5 Derivatives in the Catechol Diether Series Targeting HIV-1 Reverse Transcriptase. Chem.Biol.Drug Des. 2014 83 541 549 4MYM Crystal structure of a glyoxalase/ bleomycin resistance protein/ dioxygenase from Nocardioides 2013-09-27 2013-12-25 Eswaramoorthy, S.,Almo, S.C.,Swaminathan, S. Crystal structure of a glyoxalase/ bleomycin resistance protein/ dioxygenase from Nocardioides. To be Published 0 0 0 0 4NS1 Crystal structure of purine nucleoside phosphorylase from Porphyromonas gingivalis ATCC 33277, NYSGRC Target 30972 2013-11-27 2013-12-25 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of purine nucleoside phosphorylase from Porphyromonas gingivalis ATCC 33277, NYSGRC Target 30972. To be Published 0 0 0 0 4NSN Crystal structure of purine nucleoside phosphorylase from Porphyromonas gingivalis ATCC 33277, NYSGRC Target 030972, orthorhombic symmetry 2013-11-28 2013-12-25 Malashkevich, V.N.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Seidel, R.,Bonanno, J.B.,Almo, S.C. Crystal structure of purine nucleoside phosphorylase from Porphyromonas gingivalis ATCC 33277, NYSGRC Target 030972, orthorhombic symmetry. To be Published 0 0 0 0 4N39 24311690 Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) 2013-10-06 2014-01-01 Lazarus, M.B.,Jiang, J.,Kapuria, V.,Bhuiyan, T.,Janetzko, J.,Zandberg, W.F.,Vocadlo, D.J.,Herr, W.,Walker, S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science 2013 342 1235 1239 4N3A 24311690 Crystal Structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (1-26)E10A 2013-10-06 2014-01-01 Lazarus, M.B.,Jiang, J.,Kapuria, V.,Bhuiyan, T.,Janetzko, J.,Zandberg, W.F.,Vocadlo, D.J.,Herr, W.,Walker, S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science 2013 342 1235 1239 4NYH 24447265 Orthorhombic crystal form of pir1 dual specificity phosphatase core 2013-12-10 2014-01-08 Sankhala, R.S.,Lokareddy, R.K.,Cingolani, G. Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase. Biochemistry 2014 53 862 871 4IPV Crystal structure of Pseudomonas aeruginosa (strain: PAO1) type IV minor pilin FimU in space group P65 2013-01-10 2014-01-15 Nguyen, Y.,Sugiman-Marangos, S.N.,Bell, S.,Harvey, H.,Giltner, C.L.,Junop, M.S.,Burrows, L.L. Minor pilin FimU controls P. aeruginosa type IV pilus extension/retraction dynamics independently of other minor components To be Published 0 0 0 0 4IRV 24474782 Structure of the Helicobacter pylori CagA Oncogene Bound to the Human Tumor Suppressor Apoptosis-stimulating Protein of p53-2 2013-01-15 2014-01-15 Nesic, D.,Buti, L.,Lu, X.,Stebbins, C.E. Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2. Proc.Natl.Acad.Sci.USA 2014 111 1562 1567 4J1P 24391744 X-ray crystal structure of bromodomain 2 of human brd2 in complex with rvx208 to 1.08 A resolution 2013-02-01 2014-01-15 McLure, K.G.,Gesner, E.M.,Tsujikawa, L.,Kharenko, O.A.,Attwell, S.,Campeau, E.,Wasiak, S.,Stein, A.,White, A.,Fontano, E.,Suto, R.K.,Wong, N.C.,Wagner, G.S.,Hansen, H.C.,Young, P.R. RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One 2013 8 0 0 4J3I 24391744 X-ray crystal structure of bromodomain complex to 1.24 A resolution 2013-02-05 2014-01-15 McLure, K.G.,Gesner, E.M.,Tsujikawa, L.,Kharenko, O.A.,Attwell, S.,Campeau, E.,Wasiak, S.,Stein, A.,White, A.,Fontano, E.,Suto, R.K.,Wong, N.C.,Wagner, G.S.,Hansen, H.C.,Young, P.R. RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One 2013 8 0 0 4NK6 24398681 Crystal Structure of the periplasmic alginate epimerase AlgG 2013-11-12 2014-01-15 Wolfram, F.,Kitova, E.N.,Robinson, H.,Walvoort, M.T.,Codee, J.D.,Klassen, J.S.,Howell, P.L. Catalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgG. J.Biol.Chem. 2014 289 6006 6019 4NK8 24398681 Crystal Structure of the periplasmic alginate epimerase AlgG D317A mutant 2013-11-12 2014-01-15 Wolfram, F.,Kitova, E.N.,Robinson, H.,Walvoort, M.T.,Codee, J.D.,Klassen, J.S.,Howell, P.L. Catalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgG. J.Biol.Chem. 2014 289 6006 6019 4O92 Crystal structure of a Glutathione S-transferase from Pichia kudriavzevii (Issatchenkia orientalis), target EFI-501747 2013-12-31 2014-01-15 Kim, J.,Toro, R.,Bhosle, R.,Al Obaidi, N.F.,Morisco, L.L.,Wasserman, S.R.,Sojitra, S.,Washington, E.,Glenn, A.S.,Chowdhury, S.,Evans, B.,Stead, M.,Hillerich, B.,Love, J.,Seidel, R.D.,Imker, H.J.,Attonito, J.D.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of a Glutathione S-transferase from Pichia kudriavzevii (Issatchenkia orientalis), target EFI-501747 TO BE PUBLISHED 0 0 0 0 4N5A 24360784 Crystal structure of Efr3 2013-10-09 2014-01-22 Wu, X.,Chi, R.J.,Baskin, J.M.,Lucast, L.,Burd, C.G.,De Camilli, P.,Reinisch, K.M. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev.Cell 2014 28 19 29 4NJ5 24463519 Crystal structure of SUVH9 2013-11-08 2014-01-22 Johnson, L.M.,Du, J.,Hale, C.J.,Bischof, S.,Feng, S.,Chodavarapu, R.K.,Zhong, X.,Marson, G.,Pellegrini, M.,Segal, D.J.,Patel, D.J.,Jacobsen, S.E. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature 2014 507 124 128 4O8Y 24463465 Zinc-free Rpn11 in complex with Rpn8 2013-12-30 2014-01-22 Worden, E.J.,Padovani, C.,Martin, A. Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation. Nat.Struct.Mol.Biol. 2014 21 220 227 4NT1 24412362 Crystal structure of apo-form of Arabidopsis ACD11 (accelerated-cell-death 11) at 1.8 Angstrom resolution 2013-11-29 2014-02-05 Simanshu, D.K.,Zhai, X.,Munch, D.,Hofius, D.,Markham, J.E.,Bielawski, J.,Bielawska, A.,Malinina, L.,Molotkovsky, J.G.,Mundy, J.W.,Patel, D.J.,Brown, R.E. Arabidopsis Accelerated Cell Death 11, ACD11, Is a Ceramide-1-Phosphate Transfer Protein and Intermediary Regulator of Phytoceramide Levels. Cell Rep 2014 6 388 399 4NZG 28066922 Crystal Structure of the N-terminal domain of Moloney murine leukemia virus integrase, Northeast Structural Genomics Consortium Target OR3 2013-12-12 2014-02-05 Guan, R.,Aiyer, S.,Cote, M.L.,Xiao, R.,Jiang, M.,Acton, T.B.,Roth, M.J.,Montelione, G.T. X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition. Proteins 2017 85 647 656 4LL7 24522109 Structure of She3p amino terminus. 2013-07-09 2014-02-12 Shi, H.,Singh, N.,Esselborn, F.,Blobel, G. Structure of a myosinbulletadaptor complex and pairing by cargo. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4LL8 24522109 Complex of carboxy terminal domain of Myo4p and She3p middle fragment 2013-07-09 2014-02-12 Shi, H.,Singh, N.,Esselborn, F.,Blobel, G. Structure of a myosinbulletadaptor complex and pairing by cargo. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4MI7 24531472 Crystal Structure of Salmonella Effector Protein GtgE 2013-08-30 2014-02-12 Kohler, A.C.,Spano, S.,Galan, J.E.,Stebbins, C.E. Structural and enzymatic characterization of a host-specificity determinant from Salmonella. Acta Crystallogr.,Sect.D 2014 70 384 391 4OO6 Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) 2014-01-30 2014-02-12 Sampathkumar, P.,Brower, A.,Soniat, M.,Bonanno, J.,Hillerich, B.,Seidel, R.D.,Rout, M.P.,Chook, Y.M.,Almo, S.C. Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1) to be published 0 0 0 0 4O7Q 24406744 Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions 2013-12-26 2014-02-19 Lu, A.,Kabaleeswaran, V.,Fu, T.,Magupalli, V.G.,Wu, H. Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions. J.Mol.Biol. 2014 426 1420 1427 4K24 24465541 Structure of anti-uPAR Fab ATN-658 in complex with uPAR 2013-04-08 2014-02-26 Xu, X.,Cai, Y.,Wei, Y.,Donate, F.,Juarez, J.,Parry, G.,Chen, L.,Meehan, E.J.,Ahn, R.W.,Ugolkov, A.,Dubrovskyi, O.,O'halloran, T.V.,Huang, M.,Mazar, A.P. Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M) Plos One 2014 9 0 0 4J8L CRYSTAL STRUCTURE OF THE PYRIDOXAL-5'-PHOSPHATE DEPENDENT protein YhfS from Escherichia coli 2013-02-14 2014-03-05 Fedorov, A.A.,Fedorov, E.V.,Xiang, D.F.,Raushel, F.M.,Almo, S.C. Crystal structure of the pyridoxal-5'-phosphate dependent protein yhfs from escherichia coli To be Published 0 0 0 0 4LIF 24586168 Crystal structure of the JCV large T-antigen origin binding domain 2013-07-02 2014-03-05 Meinke, G.,Phelan, P.J.,Kalekar, R.,Shin, J.,Archambault, J.,Bohm, A.,Bullock, P.A. Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain. Plos Pathog. 2014 10 0 0 4NBP 24586168 Crystal structure of the JCV large T-antigen origin binding domain 2013-10-23 2014-03-05 Meinke, G.,Phelan, P.J.,Kalekar, R.,Shin, J.,Archambault, J.,Bohm, A.,Bullock, P.A. Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain. Plos Pathog. 2014 10 0 0 4NGF 24486018 Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 17-mer siRNA having 5'-p and UU-3' ends (3.1 Angstrom resolution) 2013-11-01 2014-03-05 Tian, Y.,Simanshu, D.K.,Ma, J.B.,Park, J.E.,Heo, I.,Kim, V.N.,Patel, D.J. A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell 2014 53 606 616 4M6F 24598738 Dimer of the G-Segment Invertase bound to a DNA substrate 2013-08-09 2014-03-12 Ritacco, C.J.,Steitz, T.A.,Wang, J. Exploiting large non-isomorphous differences for phase determination of a G-segment invertase-DNA complex. Acta Crystallogr.,Sect.D 2014 70 685 693 4M6F 24598738 Dimer of the G-Segment Invertase bound to a DNA substrate 2013-08-09 2014-03-12 Ritacco, C.J.,Steitz, T.A.,Wang, J. Exploiting large non-isomorphous differences for phase determination of a G-segment invertase-DNA complex. Acta Crystallogr.,Sect.D 2014 70 685 693 4OAU 24578532 Complete human RNase L in complex with biological activators. 2014-01-06 2014-03-12 Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A. Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science 2014 343 1244 1248 4OAV 24578532 Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate. 2014-01-06 2014-03-12 Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A. Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science 2014 343 1244 1248 4O8W 24530795 Crystal Structure of the GerD spore germination protein 2013-12-30 2014-03-19 Li, Y.,Jin, K.,Ghosh, S.,Devarakonda, P.,Carlson, K.,Davis, A.,Stewart, K.A.,Cammett, E.,Rossi, P.P.,Setlow, B.,Lu, M.,Setlow, P.,Hao, B. Structural and Functional Analysis of the GerD Spore Germination Protein of Bacillus Species. J.Mol.Biol. 2014 426 1995 2008 4OU8 24648526 Crystal structure of apocarotenoid oxygenase in the presence of C8E6 2014-02-15 2014-03-19 Sui, X.,Kiser, P.D.,Che, T.,Carey, P.R.,Golczak, M.,Shi, W.,von Lintig, J.,Palczewski, K. Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO). J.Biol.Chem. 2014 289 12286 12299 3WS3 25063871 Crystal Structure of H-2D in complex with an insulin derived peptide 2014-02-28 2014-03-26 Lamont, D.,Mukherjee, G.,Kumar, P.R.,Samanta, D.,McPhee, C.G.,Kay, T.W.H.,Almo, S.C.,DiLorenzo, T.P.,Serreze, D.V. Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses J. Immunol. 2014 193 2135 2146 4P32 24639492 Crystal structure of E. coli LptB in complex with ADP-magnesium 2014-03-05 2014-03-26 Sherman, D.J.,Lazarus, M.B.,Murphy, L.,Liu, C.,Walker, S.,Ruiz, N.,Kahne, D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proc.Natl.Acad.Sci.USA 2014 111 4982 4987 4P33 24639492 Crystal structure of E. coli LptB-E163Q in complex with ATP-sodium 2014-03-05 2014-03-26 Sherman, D.J.,Lazarus, M.B.,Murphy, L.,Liu, C.,Walker, S.,Ruiz, N.,Kahne, D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proc.Natl.Acad.Sci.USA 2014 111 4982 4987 4LMD 24586168 Crystal structure of the JCV large t-antigen origin binding domain 2013-07-10 2014-04-02 Meinke, G.,Phelan, P.J.,Kalekar, R.,Shin, J.,Archambault, J.,Bohm, A.,Bullock, P.A. Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain. Plos Pathog. 2014 10 0 0 4K1W Crystal structure of the A314P mutant of mannonate dehydratase from novosphingobium aromaticivorans complexed with mg and d-mannonate 2013-04-06 2014-04-09 Fedorov, A.A.,Fedorov, E.V.,Wichelecki, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of the A314P mutant of mannonate dehydratase from novosphingobium aromaticivorans complexed with mg and d-mannonate To be Published 0 0 0 0 4K2S Crystal structure of the mutant P317A of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg and d-gluconate 2013-04-09 2014-04-09 Fedorov, A.A.,Fedorov, E.V.,Wichelecki, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of the mutant P317A of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg and d-gluconate To be Published 0 0 0 0 4P2E 25615864 Acoustic transfer of protein crystals from agar pedestals to micromeshes for high throughput screening of heavy atom derivatives 2014-03-03 2014-04-09 Cuttitta, C.M.,Ericson, D.L.,Scalia, A.,Roessler, C.G.,Teplitsky, E.,Joshi, K.,Campos, O.,Agarwal, R.,Allaire, M.,Orville, A.M.,Sweet, R.M.,Soares, A.S. Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening. Acta Crystallogr.,Sect.D 2015 71 94 103 4PXO Crystal structure of Maleylacetoacetate isomerase from Methylobacteriu extorquens AM1 WITH BOUND MALONATE AND GSH (TARGET EFI-507068) 2014-03-24 2014-04-09 Patskovsky, Y.,Toro, R.,Bhosle, R.,Hillerich, B.,Seidel, R.D.,Washington, E.,Scott Glenn, A.,Chowdhury, S.,Evans, B.,Hammonds, J.,Imker, H.J.,Al Obaidi, N.,Stead, M.,Love, J.,Gerlt, J.A.,Armstrong, R.N.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of glutathione s-transferase zeta from Methylobacterium extorquens (TARGET EFI-507068) To be Published 0 0 0 0 4LR3 24816117 Crystal structure of E. coli YfbU at 2.5 A resolution 2013-07-19 2014-04-30 Wang, J.,Wing, R.A. Diamonds in the rough: a strong case for the inclusion of weak-intensity X-ray diffraction data. Acta Crystallogr.,Sect.D 2014 70 1491 1497 4LR3 24816117 Crystal structure of E. coli YfbU at 2.5 A resolution 2013-07-19 2014-04-30 Wang, J.,Wing, R.A. Diamonds in the rough: a strong case for the inclusion of weak-intensity X-ray diffraction data. Acta Crystallogr.,Sect.D 2014 70 1491 1497 4OHU 24527857 Crystal structure of Mycobacterium tuberculosis InhA in complex with inhibitor PT92 2014-01-18 2014-04-30 Li, H.J.,Lai, C.T.,Pan, P.,Yu, W.,Liu, N.,Bommineni, G.R.,Garcia-Diaz, M.,Simmerling, C.,Tonge, P.J. A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA. Acs Chem.Biol. 2014 9 986 993 4OIN 24755292 Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 2014-01-20 2014-05-07 Zhang, Y.,Degen, D.,Ho, M.X.,Sineva, E.,Ebright, K.Y.,Ebright, Y.W.,Mekler, V.,Vahedian-Movahed, H.,Feng, Y.,Yin, R.,Tuske, S.,Irschik, H.,Jansen, R.,Maffioli, S.,Donadio, S.,Arnold, E.,Ebright, R.H. GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife 2014 3 0 0 4Q60 Crystal structure of a 4-hydroxyproline epimerase from Burkholderia Multivorans atcc 17616, target EFI-506586, open form, with bound pyrrole-2-carboxylate 2014-04-18 2014-05-07 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Sojitra, S.,Stead, M.,Washington, E.,Glenn, A.S.,Chowdhury, S.,Evans, B.,Hammonds, J.,Hillerich, B.,Love, J.,Seidel, R.D.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) CRYSTAL STRUCTURE OF PROLINE RACEMASE Bmul_4447 FROM Burkholderia multivorans, TARGET EFI-506586 To be Published 0 0 0 0 4KPL Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with Mg,d-mannonate and 2-keto-3-deoxy-d-gluconate 2013-05-13 2014-05-14 Fedorov, A.A.,Fedorov, E.V.,Wichelecki, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with Mg,d-mannonate and 2-keto-3-deoxy-d-gluconate To be Published 0 0 0 0 4PUT 24817709 Crystal structure of the Arabidopsis thaliana TOP2 oligopeptidase 2014-03-13 2014-05-14 Wang, R.,Rajagopalan, K.,Sadre-Bazzaz, K.,Moreau, M.,Klessig, D.F.,Tong, L. Structure of the Arabidopsis thaliana TOP2 oligopeptidase. Acta Crystallogr F Struct Biol 2014 70 555 559 4KBX Crystal structure of the pyridoxal-5'-phosphate dependent protein yhfx from escherichia coli 2013-04-24 2014-05-21 Fedorov, A.A.,Fedorov, E.V.,Xiang, D.F.,Raushel, F.M.,Almo, S.C. Crystal structure of the pyridoxal-5'-phosphate dependent protein yhfx from escherichia coli To be Published 0 0 0 0 4KT2 Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg and glycerol 2013-05-19 2014-05-21 Fedorov, A.A.,Fedorov, E.V.,Wichelecki, D.,Gerlt, J.A.,Almo, S.C. Crystal structure of d-mannonate dehydratase from chromohalobacter salexigens complexed with mg and glycerol To be Published 0 0 0 0 4LTE 24847884 Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor 2013-07-23 2014-05-21 Maianti, J.P.,McFedries, A.,Foda, Z.H.,Kleiner, R.E.,Du, X.Q.,Leissring, M.A.,Tang, W.J.,Charron, M.J.,Seeliger, M.A.,Saghatelian, A.,Liu, D.R. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 2014 511 94 98 4O44 24726448 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ529), a non-nucleoside inhibitor 2013-12-18 2014-05-21 Mislak, A.C.,Frey, K.M.,Bollini, M.,Jorgensen, W.L.,Anderson, K.S. A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. Biochim.Biophys.Acta 2014 1840 2203 2211 4PT4 24916461 Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Ra] 2014-03-10 2014-05-21 Bhowmick, T.,Ghosh, S.,Dixit, K.,Ganesan, V.,Ramagopal, U.A.,Dey, D.,Sarma, S.P.,Ramakumar, S.,Nagaraja, V. Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors Nat Commun 2014 5 4124 4124 3WBW Crystal structure of Gox0644 in complex with NADPH 2013-05-22 2014-05-28 Yuan, Y.A.,Wang, C. Crystal structure of Gox0644 in complex with NADPH To be Published 0 0 0 0 3WBY Crystal structure of Gox0644 D53A mutant in complex with NADPH 2013-05-22 2014-05-28 Yuan, Y.A.,Wang, C. 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Nature 2014 511 435 439 4OPX 24922587 Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide 2014-02-06 2014-07-02 Patel, M.R.,Bhatt, A.,Steffen, J.D.,Chergui, A.,Murai, J.,Pommier, Y.,Pascal, J.M.,Trombetta, L.D.,Fronczek, F.R.,Talele, T.T. Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors. J.Med.Chem. 2014 57 5579 5601 4OQA 24922587 Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide 2014-02-07 2014-07-02 Patel, M.R.,Bhatt, A.,Steffen, J.D.,Chergui, A.,Murai, J.,Pommier, Y.,Pascal, J.M.,Trombetta, L.D.,Fronczek, F.R.,Talele, T.T. 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Biochemistry 2014 53 4671 4684 4Q3T 25007099 Crystal structure of Schistosoma mansoni arginase in complex with inhibitor NOHA 2014-04-12 2014-07-16 Hai, Y.,Edwards, J.E.,Van Zandt, M.C.,Hoffmann, K.F.,Christianson, D.W. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 2014 53 4671 4684 4Q3U 25007099 Crystal structure of Schistosoma mansoni arginase in complex with inhibitor nor-NOHA 2014-04-12 2014-07-16 Hai, Y.,Edwards, J.E.,Van Zandt, M.C.,Hoffmann, K.F.,Christianson, D.W. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 2014 53 4671 4684 4Q3V 25007099 Crystal structure of Schistosoma mansoni arginase in complex with inhibitor BEC 2014-04-12 2014-07-16 Hai, Y.,Edwards, J.E.,Van Zandt, M.C.,Hoffmann, K.F.,Christianson, D.W. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 2014 53 4671 4684 4Q40 25007099 Crystal structure of Schistosoma mansoni arginase in complex with L-valine 2014-04-12 2014-07-16 Hai, Y.,Edwards, J.E.,Van Zandt, M.C.,Hoffmann, K.F.,Christianson, D.W. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 2014 53 4671 4684 4Q41 25007099 Crystal structure of Schistosoma mansoni arginase in complex with L-lysine 2014-04-12 2014-07-16 Hai, Y.,Edwards, J.E.,Van Zandt, M.C.,Hoffmann, K.F.,Christianson, D.W. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 2014 53 4671 4684 4Q42 25007099 Crystal structure of Schistosoma mansoni arginase in complex with L-ornithine 2014-04-12 2014-07-16 Hai, Y.,Edwards, J.E.,Van Zandt, M.C.,Hoffmann, K.F.,Christianson, D.W. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 2014 53 4671 4684 4QIK 25026078 Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex 2014-05-31 2014-07-16 Tan, D.,Zhou, M.,Kiledjian, M.,Tong, L. The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Nat.Struct.Mol.Biol. 2014 21 679 685 4TQ5 25051182 Structure of a UbiA homolog from Archaeoglobus fulgidus 2014-06-10 2014-07-16 Huang, H.,Levin, E.J.,Liu, S.,Bai, Y.,Lockless, S.W.,Zhou, M. Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1. Plos Biol. 2014 12 0 0 4QB5 Crystal structure of a glyoxalase/bleomycin resistance protein from Albidiferax ferrireducens T118 2014-05-06 2014-07-23 Kumaran, D.,Almo, S.C.,Swaminathan, S. Crystal structure of a glyoxalase/bleomycin resistance protein from Albidiferax ferrireducens T118 To be Published 0 0 0 0 4QOZ 25002523 Crystal structure of the histone mRNA stem-loop, stem-loop binding protein (phosphorylated), and 3'hExo ternary complex 2014-06-21 2014-07-23 Zhang, J.,Tan, D.,DeRose, E.F.,Perera, L.,Dominski, Z.,Marzluff, W.F.,Tong, L.,Hall, T.M. Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4LW7 Crystal structure of the mutant H128S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 2013-07-26 2014-07-30 Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. Crystal structure of the mutant H128S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP To be Published 0 0 0 0 4QEN 25018018 crystal structure of KRYPTONITE in complex with mCHH DNA and SAH 2014-05-17 2014-07-30 Du, J.,Johnson, L.M.,Groth, M.,Feng, S.,Hale, C.J.,Li, S.,Vashisht, A.A.,Gallego-Bartolome, J.,Wohlschlegel, J.A.,Patel, D.J.,Jacobsen, S.E. Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol.Cell 2014 55 495 504 4QEO 25018018 crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SAH 2014-05-17 2014-07-30 Du, J.,Johnson, L.M.,Groth, M.,Feng, S.,Hale, C.J.,Li, S.,Vashisht, A.A.,Gallego-Bartolome, J.,Wohlschlegel, J.A.,Patel, D.J.,Jacobsen, S.E. Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol.Cell 2014 55 495 504 4QSF CRYSTAL STRUCTURE of AMIDOHYDROLASE PMI1525 (TARGET EFI-500319) FROM PROTEUS MIRABILIS HI4320, A COMPLEX WITH BUTYRIC ACID AND MANGANESE 2014-07-03 2014-07-30 Patskovsky, Y.,Toro, R.,Xiang, D.F.,Raushel, F.M.,Almo, S.C. Crystal Structure of Amidohydrolase Pmi1525 from Proteus Mirabilis Hi4320 To be Published 0 0 0 0 4J1V 25031347 Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor pathway, in HCV replication 2013-02-02 2014-08-06 Chung, H.Y.,Gu, M.,Buehler, E.,MacDonald, M.R.,Rice, C.M. Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction. J.Virol. 2014 88 11022 11033 4QA0 25075551 Crystal structure of C153F HDAC8 in complex with SAHA 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QA1 25075551 Crystal structure of A188T HDAC8 in complex with M344 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QA2 25075551 Crystal structure of I243N HDAC8 in complex with SAHA 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QA3 25075551 Crystal structure of T311M HDAC8 in complex with Trichostatin A (TSA) 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QA4 25075551 Crystal structure of H334R HDAC8 in complex with M344 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QA5 25075551 Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QA6 25075551 Crystal structure of I243N/Y306F HDAC8 in complex with a tetrapeptide substrate 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QA7 25075551 Crystal structure of H334R/Y306F HDAC8 in complex with a tetrapeptide substrate 2014-05-02 2014-08-06 Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol. 2014 9 2157 2164 4QRN HIGH-RESOLUTION CRYSTAL STRUCTURE of 5-CARBOXYVANILLATE DECARBOXYLASE (TARGET EFI-505250) FROM NOVOSPHINGOBIUM AROMATICIVORANS DSM 12444 COMPLEXED WITH MANGANESE AND 4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID 2014-07-01 2014-08-06 Patskovsky, Y.,Vladimirova, A.,Toro, R.,Bhosle, R.,Raushel, F.M.,Almo, S.C. Crystal Structure of 5-Carboxyvanillate Decarboxylase from Novosphingobium Aromaticivorans To be Published 0 0 0 0 4QRO CRYSTAL STRUCTURE of DIHYDROXYBENZOIC ACID DECARBBOXYLASE BPRO_2061 (TARGET EFI-500288) FROM POLAROMONAS SP. JS666 WITH BOUND MANGANESE AND AN INHIBITOR, 2-NITRORESORCINOL 2014-07-01 2014-08-06 Patskovsky, Y.,Vladimirova, A.,Toro, R.,Bhosle, R.,Raushel, F.M.,Almo, S.C. Crystal Structure of Dihydroxybenzoate Decarboxylase from Frompolaromonas Sp WITH BOUND MANGANESE AND 2-NITRORESORCINOL To be Published 0 0 0 0 4QS5 CRYSTAL STRUCTURE of 5-CARBOXYVANILLATE DECARBOXYLASE LIGW2 FROM NOVOSPHINGOBIUM AROMATICIVORANS DSM 12444 (TARGET EFI-505250) WITH BOUND MANGANESE AND 3-methoxy-4-hydroxy-5-nitrobenzoic acid, THE D314N MUTANT 2014-07-02 2014-08-06 Patskovsky, Y.,Vladimirova, A.,Toro, R.,Bhosle, R.,Gerlt, J.A.,Raushel, F.M.,Almo, S.C. Crystal Structure of 5-CARBOXYVANILLATE Decarboxylase from Novosphingobium Aromaticivorans To be Published 0 0 0 0 4QS6 CRYSTAL STRUCTURE of 5-CARBOXYVANILLATE DECARBOXYLASE LIGW2 FROM NOVOSPHINGOBIUM AROMATICIVORANS DSM 12444 (TARGET EFI-505250) WITH BOUND 4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID, NO METAL, THE D314N MUTANT 2014-07-03 2014-08-06 Patskovsky, Y.,Vladimirova, A.,Toro, R.,Bhosle, R.,Raushel, F.M.,Almo, S.C. Crystal Structure of Ligw2 Decarboxylase from Novosphingobium Aromaticivorans To be Published 0 0 0 0 4MGJ 25029089 Crystal structure of cytochrome P450 2B4 F429H in complex with 4-CPI 2013-08-28 2014-08-13 Yang, Y.,Zhang, H.,Usharani, D.,Bu, W.,Im, S.,Tarasev, M.,Rwere, F.,Pearl, N.M.,Meagher, J.,Sun, C.,Stuckey, J.,Shaik, S.,Waskell, L. Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond. Biochemistry 2014 53 5080 5091 4OYF 24842876 Crystal structure of GLTPH R397A IN Sodium-bound state 2014-02-11 2014-08-13 Verdon, G.,Oh, S.,Serio, R.N.,Boudker, O. Coupled ion binding and structural transitions along the transport cycle of glutamate transporters. Elife 2014 3 0 0 4QKT 25082811 Azurin mutant M121EM44K with copper 2014-06-09 2014-08-13 Liu, J.,Meier, K.K.,Tian, S.,Zhang, J.L.,Guo, H.,Schulz, C.E.,Robinson, H.,Nilges, M.J.,Munck, E.,Lu, Y. Redesigning the Blue Copper Azurin into a Redox-Active Mononuclear Nonheme Iron Protein: Preparation and Study of Fe(II)-M121E Azurin. J.Am.Chem.Soc. 2014 136 12337 12344 4QLW 25082811 Azurin mutant M121E with iron 2014-06-13 2014-08-13 Liu, J.,Meier, K.K.,Tian, S.,Zhang, J.L.,Guo, H.,Schulz, C.E.,Robinson, H.,Nilges, M.J.,Munck, E.,Lu, Y. Redesigning the Blue Copper Azurin into a Redox-Active Mononuclear Nonheme Iron Protein: Preparation and Study of Fe(II)-M121E Azurin. J.Am.Chem.Soc. 2014 136 12337 12344 4QSE Crystal structure of ATU4361 sugar transporter from Agrobacterium Fabrum c58, target efi-510558, with bound glycerol 2014-07-03 2014-08-13 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of maltoside transporter ATU4361 from Agrobacterium Fabrum, target EFI-510558 To be Published 0 0 0 0 4TYX 25076049 Structure of aquoferric sperm whale myoglobin L29H/F33Y/F43H/S92A mutant 2014-07-09 2014-08-13 Bhagi-Damodaran, A.,Petrik, I.D.,Marshall, N.M.,Robinson, H.,Lu, Y. Systematic tuning of heme redox potentials and its effects on O2 reduction rates in a designed oxidase in myoglobin. J.Am.Chem.Soc. 2014 136 11882 11885 4MAL TPR3 of FimV from P. aeruginosa (PAO1) 2013-08-16 2014-08-20 Daniel-Ivad, M.,Nguyen, Y.,Zhang, K.,Buensuceso, R.,Robinson, H.,Wolfram, F.,Sugiman-Marangos, S.N.,Junop, M.S.,Howell, P.L.,Burrows, L.L. Crystal structure of TPR2 from FimV To be Published 0 0 0 0 4MBQ TPR3 of FimV from P. aeruginosa (PAO1) 2013-08-19 2014-08-20 Daniel-Ivad, M.,Nguyen, Y.,Zhang, K.,Buensuceso, R.,Robinson, H.,Wolfram, F.,Sugiman-Marangos, S.N.,Junop, M.S.,Howell, P.L.,Burrows, L.L. Crystal structure of TPR2 from FimV To be Published 0 0 0 0 4PO2 25058147 Crystal Structure of the Stress-Inducible Human Heat Shock Protein HSP70 Substrate-Binding Domain in Complex with Peptide Substrate 2014-02-24 2014-08-20 Zhang, P.,Leu, J.I.,Murphy, M.E.,George, D.L.,Marmorstein, R. Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate. Plos One 2014 9 0 0 4PO2 25058147 Crystal Structure of the Stress-Inducible Human Heat Shock Protein HSP70 Substrate-Binding Domain in Complex with Peptide Substrate 2014-02-24 2014-08-20 Zhang, P.,Leu, J.I.,Murphy, M.E.,George, D.L.,Marmorstein, R. Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate. Plos One 2014 9 0 0 4QTG CRYSTAL STRUCTURE of 5-CARBOXYVANILLATE DECARBOXYLASE LIGW2 (TARGET EFI-505250) FROM NOVOSPHINGOBIUM AROMATICIVORANS DSM 12444 COMPLEXED WITH MANGANESE 2014-07-07 2014-08-20 Patskovsky, Y.,Vladimirova, A.,Toro, R.,Bhosle, R.,Raushel, F.M.,Almo, S.C. Crystal Structure of 5-Carboxyvanillate Decarboxylase LIGW2 from Novosphingobium Aromaticivorans To be Published 0 0 0 0 4QUC 25085419 Crystal structure of chromodomain of Rhino 2014-07-10 2014-08-20 Le Thomas, A.,Stuwe, E.,Li, S.,Du, J.,Marinov, G.,Rozhkov, N.,Chen, Y.C.,Luo, Y.,Sachidanandam, R.,Toth, K.F.,Patel, D.,Aravin, A.A. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 2014 28 1667 1680 4R2B Crystal structure of sugar transporter Oant_3817 from Ochrobactrum anthropi, target EFI-510528, with bound glucose 2014-08-11 2014-08-27 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal Structure of Glucose Transporter Oant_3817 from Ochrobactrum Anthropi, Target EFI-510528 To be Published 0 0 0 0 4R2F Crystal structure of sugar transporter ACHL_0255 from Arthrobacter chlorophenolicus A6, target EFI-510633, with bound laminaribiose 2014-08-11 2014-08-27 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal structure of sugar transporter ACHL_0255 from Arthrobacter chlorophenolicus, target EFI-510633 To be Published 0 0 0 0 4U4F 25103407 Structure of GluA2* in complex with partial agonist (S)-5-Nitrowillardiine 2014-07-23 2014-08-27 Yelshanskaya, M.V.,Li, M.,Sobolevsky, A.I. Structure of an agonist-bound ionotropic glutamate receptor. Science 2014 345 1070 1074 4Q2R Structural Proteomics From Crude Native Rod Outer Segments 2014-04-09 2014-09-03 Baker, B.Y.,Shi, W.,Palczewski, K. Structural Proteomics From Crude Native Rod Outer Segments To be Published 0 0 0 0 4R5J 25148104 Crystal structure of the DnaK C-terminus (Dnak-SBD-A) 2014-08-21 2014-09-10 Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol. 2014 9 2508 2516 4R5K 25148104 Crystal structure of the DnaK C-terminus (Dnak-SBD-B) 2014-08-21 2014-09-10 Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol. 2014 9 2508 2516 4R6H Crystal structure of putative binding protein msme from bacillus subtilis subsp. subtilis str. 168, target efi-510764, an open conformation 2014-08-25 2014-09-10 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al obaidi, N.,Chamala, S.,Scott glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Transporter Msme from Bacillus Subtilis, Target Efi-510764 To be Published 0 0 0 0 4R6K Crystal structure of ABC transporter substrate-binding protein YesO from Bacillus subtilis, TARGET EFI-510761, an open conformation 2014-08-25 2014-09-10 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal structure of transporter Yeso from Bacillus subtilis, Target Efi-510761 To be Published 0 0 0 0 4R6Y Crystal structure of solute-binding protein stm0429 from salmonella enterica subsp. enterica serovar typhimurium str. lt2, target efi-510776, a closed conformation, in complex with glycerol and acetate 2014-08-26 2014-09-10 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al obaidi, N.,Chamala, S.,Scott glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Transporter STM0429 from Salmonella Enterica To be Published 0 0 0 0 4OYE 24842876 Crystal structure of GltPh R397A in apo 2014-02-11 2014-09-17 Verdon, G.,Oh, S.,Serio, R.N.,Boudker, O. Coupled ion binding and structural transitions along the transport cycle of glutamate transporters. Elife 2014 3 0 0 4P2V 25225400 Structure of the AI-2 processing enzyme LsrF in complex with the product of the LsrG reaction P-HPD 2014-03-04 2014-09-17 Marques, J.C.,Oh, I.K.,Ly, D.C.,Lamosa, P.,Ventura, M.R.,Miller, S.T.,Xavier, K.B. LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2. Proc.Natl.Acad.Sci.USA 2014 111 14235 14240 4QNU 25855808 Crystal structure of CmoB bound with Cx-SAM in P21212 2014-06-18 2014-09-17 Kim, J.,Xiao, H.,Koh, J.,Wang, Y.,Bonanno, J.B.,Thomas, K.,Babbitt, P.C.,Brown, S.,Lee, Y.S.,Almo, S.C. Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. Nucleic Acids Res. 2015 43 4602 4613 4QNV 25855808 Crystal structure of Cx-SAM bound CmoB from E. coli in P6122 2014-06-18 2014-09-17 Kim, J.,Xiao, H.,Koh, J.,Wang, Y.,Bonanno, J.B.,Thomas, K.,Babbitt, P.C.,Brown, S.,Lee, Y.S.,Almo, S.C. Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. Nucleic Acids Res. 2015 43 4602 4613 4QNX 25855808 Crystal structure of apo-CmoB 2014-06-18 2014-09-17 Kim, J.,Xiao, H.,Koh, J.,Wang, Y.,Bonanno, J.B.,Thomas, K.,Babbitt, P.C.,Brown, S.,Lee, Y.S.,Almo, S.C. Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. Nucleic Acids Res. 2015 43 4602 4613 4R7W Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae liganded with phosphonocytosine 2014-08-28 2014-09-17 Fedorov, A.A.,Fedorov, E.V.,Hitchcock, D.S.,Raushel, F.M.,Almo, S.C. Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae liganded with phosphonocytosine To be Published 0 0 0 0 4R85 Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae liganded with 5-methylcytosine 2014-08-29 2014-09-17 Fedorov, A.A.,Fedorov, E.V.,Hitchcock, D.S.,Raushel, F.M.,Almo, S.C. Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae liganded with 5-methylcytosine To be Published 0 0 0 0 4R88 Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae liganded with 5-fluorocytosine 2014-08-29 2014-09-17 Fedorov, A.A.,Fedorov, E.V.,Hitchcock, D.S.,Raushel, F.M.,Almo, S.C. Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae liganded with 5-fluorocytosine To be Published 0 0 0 0 3WJM 24639361 Crystal structure of Bombyx mori Sp2/Sp3 heterohexamer 2013-10-11 2014-09-24 Hou, Y.,Li, J.,Li, Y.,Dong, Z.,Xia, Q.,Yuan, Y.A. Crystal structure of Bombyx mori arylphorins reveals a 3:3 heterohexamer with multiple papain cleavage sites Protein Sci. 2014 23 735 746 3WJS Crystal structure of GYE (old yellow enzyme) 2013-10-14 2014-09-24 Yuan, Y.A.,Yin, B. Crystal structure of GYE (old yellow enzyme) To be Published 0 0 0 0 4K9G 25050663 1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound 2013-04-19 2014-09-24 Ioannou, K.,Cheng, K.F.,Crichlow, G.V.,Birmpilis, A.I.,Lolis, E.J.,Tsitsilonis, O.E.,Al-Abed, Y. ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. INT J ONCOL. 2014 45 1457 1468 4QYD 25281266 Crystal Structure of the human BRPF1 bromodomain in complex with a histone H4K12ac peptide 2014-07-24 2014-09-24 Lubula, M.Y.,Eckenroth, B.E.,Carlson, S.,Poplawski, A.,Chruszcz, M.,Glass, K.C. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. 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P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation. Plos Pathog. 2014 10 0 0 4W2E 25104389 Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome 2014-06-04 2014-10-01 Gagnon, M.G.,Lin, J.,Bulkley, D.,Steitz, T.A. Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome. Science 2014 345 684 687 4N8T 24769418 Human hemoglobin nitric oxide adduct 2013-10-18 2014-10-08 Yi, J.,Soares, A.S.,Richter-Addo, G.B. Crystallographic characterization of the nitric oxide derivative of R-state human hemoglobin. Nitric Oxide 2014 39 46 50 4QUV 25307054 Structure of an integral membrane delta(14)-sterol reductase 2014-07-12 2014-10-08 Li, X.,Roberti, R.,Blobel, G. Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum. Nature 2015 517 104 107 4KNX 25262942 Hin GlmU Bound to WG176 2013-05-10 2014-10-15 Doig, P.,Boriack-Sjodin, P.A.,Dumas, J.,Hu, J.,Itoh, K.,Johnson, K.,Kazmirski, S.,Kinoshita, T.,Kuroda, S.,Sato, T.O.,Sugimoto, K.,Tohyama, K.,Aoi, H.,Wakamatsu, K.,Wang, H. Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg.Med.Chem. 2014 22 6256 6269 4Q0D 25127103 Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, methotrexate and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid. 2014-04-01 2014-10-15 Kumar, V.P.,Cisneros, J.A.,Frey, K.M.,Castellanos-Gonzalez, A.,Wang, Y.,Gangjee, A.,White, A.C.,Jorgensen, W.L.,Anderson, K.S. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorg.Med.Chem.Lett. 2014 24 4158 4161 4Q0E 25127103 Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid. 2014-04-01 2014-10-15 Kumar, V.P.,Cisneros, J.A.,Frey, K.M.,Castellanos-Gonzalez, A.,Wang, Y.,Gangjee, A.,White, A.C.,Jorgensen, W.L.,Anderson, K.S. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorg.Med.Chem.Lett. 2014 24 4158 4161 4U6U 25331899 Crystal Structure of the Cog5-Cog7 complex from Kluyveromyces lactis 2014-07-29 2014-10-22 Ha, J.Y.,Pokrovskaya, I.D.,Climer, L.K.,Shimamura, G.R.,Kudlyk, T.,Jeffrey, P.D.,Lupashin, V.V.,Hughson, F.M. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Proc.Natl.Acad.Sci.USA 2014 111 15762 15767 4QSH 25215494 Crystal Structure of L. monocytogenes Pyruvate Carboxylase in complex with Cyclic-di-AMP 2014-07-04 2014-10-29 Sureka, K.,Choi, P.H.,Precit, M.,Delince, M.,Pensinger, D.A.,Huynh, T.N.,Jurado, A.R.,Goo, Y.A.,Sadilek, M.,Iavarone, A.T.,Sauer, J.D.,Tong, L.,Woodward, J.J. The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function. Cell(Cambridge,Mass.) 2014 158 1389 1401 4QSK 25215494 Crystal Structure of L. monocytogenes Pyruvate Carboxylase in complex with Cyclic-di-AMP 2014-07-04 2014-10-29 Sureka, K.,Choi, P.H.,Precit, M.,Delince, M.,Pensinger, D.A.,Huynh, T.N.,Jurado, A.R.,Goo, Y.A.,Sadilek, M.,Iavarone, A.T.,Sauer, J.D.,Tong, L.,Woodward, J.J. The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function. Cell(Cambridge,Mass.) 2014 158 1389 1401 4QSL 25215494 Crystal Structure of Listeria Monocytogenes Pyruvate Carboxylase 2014-07-04 2014-10-29 Sureka, K.,Choi, P.H.,Precit, M.,Delince, M.,Pensinger, D.A.,Huynh, T.N.,Jurado, A.R.,Goo, Y.A.,Sadilek, M.,Iavarone, A.T.,Sauer, J.D.,Tong, L.,Woodward, J.J. The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function. Cell(Cambridge,Mass.) 2014 158 1389 1401 4RK0 Crystal structure of LacI family transcriptional regulator from Enterococcus faecalis V583, Target EFI-512923, with bound ribose 2014-10-11 2014-10-29 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal Structure of LacI Transcriptional Regulator Ef_2962 from Enterococcus faecalis V583, Target EFI-512923 To be Published 0 0 0 0 4RK1 Crystal structure of LacI family transcriptional regulator from Enterococcus faecium, Target EFI-512930, with bound ribose 2014-10-11 2014-10-29 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal Structure of LacI Transcriptional Regulator Rbsr from Enterococcus faecium, Target EFI-512930 To be Published 0 0 0 0 4RK6 Crystal structure of LacI family transcriptional regulator CCPA from Weissella paramesenteroides, Target EFI-512926, with bound glucose 2014-10-11 2014-10-29 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal structure of transcriptional regulator CCPA from Weissella paramesenteroides, Target EFI-512926 To be Published 0 0 0 0 4RK7 Crystal structure of LacI family transcriptional regulator CCPA from Weissella paramesenteroides, Target EFI-512926, with bound sucrose 2014-10-11 2014-10-29 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal structure of transcriptional regulator CCPA from Weissella paramesenteroides, Target EFI-512926 To be Published 0 0 0 0 4O4G 24726448 Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ527), a non-nucleoside inhibitor 2013-12-18 2014-11-05 Mislak, A.C.,Frey, K.M.,Bollini, M.,Jorgensen, W.L.,Anderson, K.S. A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. Biochim.Biophys.Acta 2014 1840 2203 2211 4RCN 25383525 Structure and function of a single-chain, multi-domain long-chain acyl-coa carboxylase 2014-09-16 2014-11-05 Tran, T.H.,Hsiao, Y.S.,Jo, J.,Chou, C.Y.,Dietrich, L.E.,Walz, T.,Tong, L. Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase. Nature 2015 518 120 124 4RJZ Crystal structure of ATU4361 sugar transporter from Agrobacterium fabrum C58, target EFI-510558, an open conformation 2014-10-11 2014-11-05 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Maltoside Transporter ATU4361 from Agrobacterium Fabrum, Target EFI-510558 To be Published 0 0 0 0 4RK2 Crystal structure of sugar transporter RHE_PF00321 from Rhizobium etli, target EFI-510806, an open conformation 2014-10-11 2014-11-05 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of Sugar Transporter RHE_Pf00321 from Rhizobium Etli, Target EFI-510806 To be Published 0 0 0 0 4RK5 Crystal structure of LacI family transcriptional regulator from Lactobacillus casei, Target EFI-512911, with bound sucrose 2014-10-11 2014-11-05 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal Structure of LacI Transcriptional Regulator Lsei_2103 from Lactobacillus casei, Target EFI-512911 To be Published 0 0 0 0 4RK9 CRYSTAL STRUCTURE OF SUGAR TRANSPORTER BL01359 FROM Bacillus licheniformis, TARGET EFI-510856, IN COMPLEX WITH STACHYOSE 2014-10-12 2014-11-05 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C.,Enzyme Function Initiative (EFI) CRYSTAL STRUCTURE OF SUGAR TRANSPORTER BL01359 FROM Bacillus licheniformis, TARGET EFI-510856 To be Published 0 0 0 0 4Q6G 25385624 Crystal Structure of the C-terminal domain of AcKRS-1 bound with N-acetyl-lysine and ADPNP 2014-04-22 2014-11-12 Guo, L.T.,Wang, Y.S.,Nakamura, A.,Eiler, D.,Kavran, J.M.,Wong, M.,Kiessling, L.L.,Steitz, T.A.,O'Donoghue, P.,Soll, D. Polyspecific pyrrolysyl-tRNA synthetases from directed evolution. Proc.Natl.Acad.Sci.USA 2014 111 16724 16729 4RKQ Crystal structure of LacI family transcriptional regulator from Arthrobacter sp. FB24, target EFI-560007 2014-10-13 2014-11-12 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Burley, S.K.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of LacI Transcriptional Regulator PurR from Arthrobacter Sp, Target Nysgxrc 11027R To be Published 0 0 0 0 4RKR Crystal structure of LacI family transcriptional regulator from Arthrobacter sp. FB24, target EFI-560007, complex with lactose 2014-10-13 2014-11-12 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Burley, S.K.,Almo, S.C.,Enzyme Function Initiative (EFI) Crystal Structure of LacI Transcriptional Regulator PurR from Arthrobacter Sp, Target Nysgxrc 11027R To be Published 0 0 0 0 4RPF Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715 2014-10-30 2014-11-12 Patskovsky, Y.,Bhosle, R.,Toro, R.,Hillerich, B.,Gizzi, A.,Garforth, S.,Kar, A.,Chan, M.K.,Lafluer, J.,Patel, H.,Matikainen, B.,Chamala, S.,Lim, S.,Celikgil, A.,Villegas, G.,Evans, B.,Love, J.,Fiser, A.,Seidel, R.,Bonanno, J.B.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) Crystal Structure of Homoserine Kinase from Yersinia Pestis Nepal516, Nysgrc Target 032715 To be Published 0 0 0 0 4WCJ 25359777 Structure of IcaB from Ammonifex degensii 2014-09-04 2014-11-12 Little, D.J.,Bamford, N.C.,Pokrovskaya, V.,Robinson, H.,Nitz, M.,Howell, P.L. Structural Basis for the De-N-acetylation of Poly-beta-1,6-N-acetyl-d-glucosamine in Gram-positive Bacteria. J.Biol.Chem. 2014 289 35907 35917 4NEJ Small molecular fragment bound to crystal contact interface of Interleukin-2 2013-10-29 2014-11-19 Brenke, R.,Jehle, S.,Vajda, S.,Allen, K.N.,Kozakov, D. Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2 To be Published 0 0 0 0 4NEM Small molecular fragment bound to crystal contact interface of Interleukin-2 2013-10-29 2014-11-19 Jehle, S.,Brenke, R.,Vajda, S.,Allen, K.N.,Kozakov, D. Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2 To be Published 0 0 0 0 4RK4 Crystal structure of LacI family transcriptional regulator from Lactobacillus casei, Target EFI-512911, with bound glucose 2014-10-11 2014-11-19 Patskovsky, Y.,Toro, R.,Bhosle, R.,Al Obaidi, N.,Chamala, S.,Scott Glenn, A.,Attonito, J.D.,Chowdhury, S.,Lafleur, J.,Siedel, R.D.,Hillerich, B.,Love, J.,Whalen, K.L.,Gerlt, J.A.,Almo, S.C. Crystal Structure of LacI Transcriptional Regulator Lsei_2103 from Lactobacillus casei, Target EFI-512911 To be Published 0 0 0 0 4NI8 Crystal structure of 5-carboxyvanillate decarboxylase LigW from Sphingomonas paucimobilis complexed with Mn and 5-methoxyisophtalic acid 2013-11-05 2014-11-26 Fedorov, A.A.,Fedorov, E.V.,Vladimirova, A.,Raushel, F.M.,Almo, S.C. Crystal structure of 5-carboxyvanillate decarboxylase LigW from Sphingomonas paucimobilis complexed with Mn and 5-methoxyisophtalic acid To be Published 0 0 0 0 4RP3 29261291 Crystal Structure of the L27 Domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster bound to a potassium ion (space group P212121) 2014-10-29 2014-11-26 Ghosh, A.,Ramagopal, U.A.,Bonanno, J.B.,Brenowitz, M.,Almo, S.C. Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Biochemistry 2018 57 1293 1305 4RP4 29261291 Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P212121) 2014-10-29 2014-11-26 Ghosh, A.,Ramagopal, U.A.,Bonanno, J.B.,Brenowitz, M.,Almo, S.C. Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Biochemistry 2018 57 1293 1305 4RP5 29261291 Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P21) 2014-10-29 2014-11-26 Ghosh, A.,Ramagopal, U.A.,Bonanno, J.B.,Brenowitz, M.,Almo, S.C. Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Biochemistry 2018 57 1293 1305 4RQA Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target ID NYSGRC-029686) from Staphylococcus aureus (orthorhombic space group) 2014-10-31 2014-11-26 Ghosh, A.,Ahmed, A.,Bhoshle, R.,Seidel, R.,Stead, M.,Toro, R.,Schramm, V.L.,Almo, S.C.,New York Structural Genomics Research Consortium (NYSGRC) Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target ID NYSGRC-029686) from Staphylococcus aureus (orthorhombic space group) To be Published 0 0 0 0 4OJV 25050706 Crystal structure of unliganded yeast PDE1 2014-01-21 2014-12-03 Tian, Y.,Cui, W.,Huang, M.,Robinson, H.,Wan, Y.,Wang, Y.,Ke, H. Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate. Biochemistry 2014 53 4938 4945 4OJX 25050706 crystal structure of yeast phosphodiesterase-1 in complex with GMP 2014-01-21 2014-12-03 Tian, Y.,Cui, W.,Huang, M.,Robinson, H.,Wan, Y.,Wang, Y.,Ke, H. Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate. Biochemistry 2014 53 4938 4945 4QU4 25414331 Improved refinement of the Mtr4 apo crystal structure 2014-07-10 2014-12-03 Taylor, L.L.,Jackson, R.N.,Rexhepaj, M.,King, A.K.,Lott, L.K.,van Hoof, A.,Johnson, S.J. The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding. Nucleic Acids Res. 2014 42 13861 13872 4W8P 25465129 Crystal structure of RIAM TBS1 in complex with talin R7R8 domains 2014-08-25 2014-12-03 Chang, Y.C.,Zhang, H.,Franco-Barraza, J.,Brennan, M.L.,Patel, T.,Cukierman, E.,Wu, J. Structural and Mechanistic Insights into the Recruitment of Talin by RIAM in Integrin Signaling. Structure 2014 22 1810 1820 4WE1 25408842 Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600) 2014-09-09 2014-12-03 Lee, W.G.,Frey, K.M.,Gallardo-Macias, R.,Spasov, K.A.,Bollini, M.,Anderson, K.S.,Jorgensen, W.L. Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. Acs Med.Chem.Lett. 2014 5 1259 1262 4QGE 25432025 phosphodiesterase-9A in complex with inhibitor WYQ-C36D 2014-05-22 2014-12-10 Shao, Y.X.,Huang, M.,Cui, W.,Feng, L.J.,Wu, Y.,Cai, Y.,Li, Z.,Zhu, X.,Liu, P.,Wan, Y.,Ke, H.,Luo, H.B. Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent. J.Med.Chem. 2014 57 10304 10313 4X23 23723239 CRYSTAL STRUCTURE OF CENP-C IN COMPLEX WITH THE NUCLEOSOME CORE PARTICLE 2014-11-25 2014-12-10 Kato, H.,Jiang, J.S.,Zhou, B.R.,Rozendaal, M.,Feng, H.,Ghirlando, R.,Xiao, T.S.,Straight, A.F.,Bai, Y. A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science 2013 340 1110 1113 4R4Y 25456816 Structural basis of a point mutation that causes the genetic disease Aspartylglucosaminuria 2014-08-20 2014-12-17 Sui, L.,Lakshminarasimhan, D.,Pande, S.,Guo, H.C. Structural Basis of a Point Mutation that Causes the Genetic Disease Aspartylglucosaminuria. Structure 2014 22 1855 1861 4RWH Crystal structure of T cell costimulatory ligand B7-1 (CD80) 2014-12-04 2014-12-17 Fedorov, A.A.,Fedorov, E.V.,Samanta, D.,Hillerich, B.,Seidel, R.D.,Almo, S.C. Crystal structure of T cell costimulatory ligand B7-1 (CD80) To be Published 0 0 0 0 4RWW 25693966 Crystal Structure of L. monocytogenes PstA in complex with cyclic-di-AMP 2014-12-07 2014-12-17 Choi, P.H.,Sureka, K.,Woodward, J.J.,Tong, L. Molecular basis for the recognition of cyclic-di-AMP by PstA, a PII -like signal transduction protein. Microbiologyopen 2015 4 361 374 4RWX 25693966 Crystal Structure of L. monocytogenes PstA 2014-12-07 2014-12-17 Choi, P.H.,Sureka, K.,Woodward, J.J.,Tong, L. Molecular basis for the recognition of cyclic-di-AMP by PstA, a PII -like signal transduction protein. Microbiologyopen 2015 4 361 374 4REB 25500724 Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer 2014-09-22 2014-12-24 Zhao, Q.,Xue, X.,Longerich, S.,Sung, P.,Xiong, Y. Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer. Nat Commun 2014 5 5726 5726 4WNL 25535369 The X-ray structure of a RNA-binding protein complex 2014-10-13 2014-12-24 Singh, N.,Blobel, G.,Shi, H. Hooking She3p onto She2p for myosin-mediated cytoplasmic mRNA transport. Proc.Natl.Acad.Sci.USA 2015 112 142 147 3WUY 25450592 Crystal structure of Nit6803 2014-05-09 2014-12-31 Zhang, L.,Yin, B.,Wang, C.,Jiang, S.,Wang, H.,Yuan, Y.A.,Wei, D. Structural insights into enzymatic activity and substrate specificity determination by a single amino acid in nitrilase from Syechocystis sp. PCC6803 J.Struct.Biol. 2014 188 93 101 4R30 25538239 Structure of human laforin dual specificity phosphatase domain 2014-08-13 2014-12-31 Sankhala, R.S.,Koksal, A.C.,Ho, L.,Nitschke, F.,Minassian, B.A.,Cingolani, G. Dimeric quaternary structure of human laforin. J.Biol.Chem. 2015 290 4552 4559 4RHI 25536859 Crystal structure of SeMet-labeled wild-type T. brucei arginase-like protein in P321 space group 2014-10-02 2014-12-31 Hai, Y.,Kerkhoven, E.J.,Barrett, M.P.,Christianson, D.W. Crystal Structure of an Arginase-like Protein from Trypanosoma brucei That Evolved without a Binuclear Manganese Cluster. Biochemistry 2015 54 458 471 4RHJ 25536859 Crystal structure of wild-type T. brucei arginase-like protein in a reduced form 2014-10-02 2014-12-31 Hai, Y.,Kerkhoven, E.J.,Barrett, M.P.,Christianson, D.W. 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Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications To Be Published 0 0 0 0 5YDI Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector anopheles gambiae, new crystal packing 2017-09-13 2018-03-07 Han, Q.,Guan, H.,Ding, H.,Liao, C.,Robinson, H.,Li, J. Crystal structures of acetylcholinesterase of the malaria vector Anopheles gambiae reveal a polymerization interface, ligand binding residues and post translational modifications To Be Published 0 0 0 0 5YDJ Crystal structure of anopheles gambiae acetylcholinesterase in complex with PMSF 2017-09-13 2018-03-07 Han, Q.,Guan, H.,Ding, H.,Liao, C.,Robinson, H.,Li, J. 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