PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 2GH1 Crystal Structure of the putative SAM-dependent methyltransferase BC2162 from Bacillus cereus, Northeast Structural Genomics Target BcR20. 2006-03-24 2006-04-04 Forouhar, F.,Neely, H.,Jayaraman, S.,Ciao, M.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the putative SAM-dependent methyltransferase BC2162 from Bacillus cereus, Northeast Structural Genomics Target BcR20. To be Published 0 0 0 0 2GUV 16828114 Conformational Transition between Four- and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction 2006-05-01 2006-07-25 Liu, J.,Zheng, Q.,Deng, Y.,Kallenbach, N.R.,Lu, M. Conformational Transition between Four and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction. J.Mol.Biol. 2006 361 168 179 2HXG Crystal Structure of Mn2+ bound ECAI 2006-08-03 2006-08-15 Zhu, W.,Chance, M.R.,Manjasetty, B.A. Crystal Structure of Mn2+-bound Escherichia coli L-arabinose Isomerase (ECAI) and Implications in Protein Catalytic Mechanism and Thermo-Stability. J.Young.Investig. 2007 17 0 0 2HY6 17030805 A seven-helix coiled coil 2006-08-04 2006-10-24 Liu, J.,Zheng, Q.,Deng, Y.,Cheng, C.S.,Kallenbach, N.R.,Lu, M. A seven-helix coiled coil. Proc.Natl.Acad.Sci.Usa 2006 103 15457 15462 2O1E Crystal Structure of the Metal-dependent Lipoprotein YcdH from Bacillus subtilis, Northeast Structural Genomics Target SR583 2006-11-28 2006-12-12 Forouhar, F.,Zhou, W.,Seetharaman, J.,Chen, C.X.,Fang, Y.,Cunningham, K.,Ma, L.-C.,Janjua, H.,Xiao, R.,Baran, M.C.,Liu, J.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal Structure of the Metal-dependent Lipoprotein YcdH from Bacillus subtilis, Northeast Structural Genomics Target SR583 To be Published 0 0 0 0 2NXN 17215866 T. thermophilus ribosomal protein L11 methyltransferase (PrmA) in complex with ribosomal protein L11 2006-11-17 2006-12-26 Demirci, H.,Gregory, S.T.,Dahlberg, A.E.,Jogl, G. Recognition of ribosomal protein L11 by the protein trimethyltransferase PrmA. Embo J. 2007 26 567 577 2O1X 17135236 1-deoxy-D-xylulose 5-phosphate synthase (DXS) from Deinococcus radiodurans 2006-11-29 2006-12-26 Xiang, S.,Usunow, G.,Lange, G.,Busch, M.,Tong, L. Crystal Structure of 1-Deoxy-D-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis. J.Biol.Chem. 2007 282 2676 2682 2IEQ 17176042 Core Structure of S2 from the Human Coronavirus NL63 Spike Glycoprotein 2006-09-19 2007-01-09 Zheng, Q.,Deng, Y.,Liu, J.,Hoek, L.V.,Berkhout, B.,Lu, M. Core Structure of S2 from the Human Coronavirus NL63 Spike Glycoprotein Biochemistry 2006 45 15205 15215 2NRN 17189475 Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant 2006-11-02 2007-04-17 Deng, Y.,Zheng, Q.,Liu, J.,Cheng, C.S.,Kallenbach, N.R.,Lu, M. Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant. Protein Sci. 2007 16 323 328 2PH5 Crystal structure of the homospermidine synthase hss from Legionella pneumophila in complex with NAD, Northeast Structural Genomics Target LgR54 2007-04-10 2007-05-15 Forouhar, F.,Hussain, M.,Seetharaman, J.,Fang, Y.,Janjua, H.,Xiao, R.,Cunningham, K.,Ma, L.-C.,Owens, L.,Liu, J.,Baran, M.C.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the homospermidine synthase hss from Legionella pneumophila in complex with NAD. To be Published 0 0 0 0 2ELA 17502098 Crystal Structure of the PTB domain of human APPL1 2007-03-27 2007-05-29 Li, J.,Mao, X.,Dong, L.Q.,Liu, F.,Tong, L. Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure 2007 15 525 533 2POP 17560374 The Crystal Structure of TAB1 and BIR1 complex 2007-04-27 2007-07-03 Lu, M.,Lin, S.C.,Huang, Y.,Kang, Y.J.,Rich, R.,Lo, Y.C.,Myszka, D.,Han, J.,Wu, H. XIAP Induces NF-kappaB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization. Mol.Cell 2007 26 689 702 2QGS Crystal structure of SE1688 protein from Staphylococcus epidermidis. Northeast Structural Genomics Consortium target SeR89 2007-06-29 2007-07-17 Forouhar, F.,Su, M.,Benach, J.,Seetharaman, J.,Chen, C.X.,Fang, Y.,Cunningham, K.,Owen, L.,Ma, L.-C.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of SE1688 protein from Staphylococcus epidermidis. To be Published 0 0 0 0 2QGV Crystal structure of hydrogenase-1 operon protein hyaE from Shigella flexneri. Northeast Structural Genomics Consortium Target SfR170 2007-06-29 2007-07-17 Forouhar, F.,Su, M.,Seetharaman, J.,Benach, J.,Wang, D.,Fang, Y.,Cunningham, K.,Ma, L.-C.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of hydrogenase-1 operon protein hyaE from Shigella flexneri. To be Published 0 0 0 0 2QRA 17698078 Crystal structure of XIAP BIR1 domain (P21 form) 2007-07-27 2007-09-18 Lin, S.C.,Huang, Y.,Lo, Y.C.,Lu, M.,Wu, H. Crystal structure of the BIR1 domain of XIAP in two crystal forms J.Mol.Biol. 2007 372 847 854 2PWL 17803937 Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome. 2007-05-11 2007-09-25 Chen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell 2007 27 717 730 2PZ5 17803937 Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome 2007-05-17 2007-09-25 Chen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell 2007 27 717 730 2R6Z Crystal structure of the SAM-dependent methyltransferase NGO1261 from Neisseria gonorrhoeae, Northeast Structural Genomics Consortium Target NgR48 2007-09-06 2007-09-25 Forouhar, F.,Abashidze, M.,Seetharaman, J.,Mao, L.,Nwosu, C.,Fang, Y.,Xiao, R.,Baran, M.C.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) Crystal structure of the SAM-dependent methyltransferase NGO1261 from Neisseria gonorrhoeae. To be Published 0 0 0 0 2R76 Crystal structure of the rare lipoprotein B (SO_1173) from Shewanella oneidensis, Northeast Structural Genomics Consortium Target SoR91A 2007-09-07 2007-09-25 Forouhar, F.,Chen, Y.,Seetharaman, J.,Mao, L.,Maglaqui, M.,Owen, L.A.,Cunningham, K.,Fang, Y.,Xiao, R.,Baran, M.C.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the rare lipoprotein B (SO_1173) from Shewanella oneidensis. To be Published 0 0 0 0 2R7D 22133431 Crystal structure of ribonuclease II family protein from Deinococcus radiodurans, triclinic crystal form. NorthEast Structural Genomics target DrR63 2007-09-07 2007-10-02 Schmier, B.J.,Seetharaman, J.,Deutscher, M.P.,Hunt, J.F.,Malhotra, A. The Structure and Enzymatic Properties of a Novel RNase II Family Enzyme from Deinococcus radiodurans. J.Mol.Biol. 2012 415 547 559 2RJB Crystal structure of uncharacterized protein YdcJ (SF1787) from Shigella flexneri which includes domain DUF1338. Northeast Structural Genomics Consortium target SfR276 2007-10-14 2007-10-30 Seetharaman, J.,Chen, Y.,Wang, D.,Fang, Y.,Cunningham, K.,Ma, L.-C.,Xia, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of uncharacterized protein YdcJ (SF1787) from Shigella flexneri which includes domain DUF1338. To be Published 0 0 0 0 3BDU Crystal structure of protein Q6D8G1 at the resolution 1.9 A. Northeast Structural Genomics Consortium target EwR22A. 2007-11-15 2007-11-27 Kuzin, A.P.,Su, M.,Seetharaman, J.,Wang, D.,Fang, Y.,Cunningham, K.,Owens, L.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of protein Q6D8G1 at the resolution 1.9 A. To be Published 0 0 0 0 3BIJ Crystal structure of protein GSU0716 from Geobacter sulfurreducens. Northeast Structural Genomics target GsR13 2007-11-30 2007-12-11 Forouhar, F.,Neely, H.,Su, M.,Seetharaman, J.,Benach, J.,Conover, K.,Fang, Y.,Xiao, R.,Owen, L.A.,Maglaqui, M.,Cunningham, K.,Baran, M.C.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of protein GSU0716 from Geobacter sulfurreducens. To be Published 0 0 0 0 3BID Crystal structure of the NMB1088 protein from Neisseria meningitidis. Northeast Structural Genomics Consortium target MR91 2007-11-30 2007-12-18 Forouhar, F.,Neely, H.,Seetharaman, J.,Mao, L.,Fang, Y.,Xiao, R.,Owen, L.A.,Maglaqui, M.,Cunningham, K.,Baran, M.C.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the NMB1088 protein from Neisseria meningitidis. To be Published 0 0 0 0 2PL9 18083806 Crystal Structure of CheY-Mg(2+)-BeF(3)(-) in Complex with CheZ(C19) Peptide solved from a P2(1)2(1)2 Crystal 2007-04-19 2008-01-15 Guhaniyogi, J.,Wu, T.,Patel, S.S.,Stock, A.M. Interaction of CheY with the C-terminal peptide of CheZ. J.Bacteriol. 2008 190 1419 1428 3BU2 Crystal structure of a tRNA-binding protein from Staphylococcus saprophyticus subsp. saprophyticus. Northeast Structural Genomics Consortium target SyR77 2007-12-31 2008-01-22 Seetharaman, J.,Su, M.,Forouhar, F.,Wang, D.,Fang, Y.,Cunningham, K.,Ma, L.-C.,Xia, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of a tRNA-binding protein from Staphylococcus saprophyticus subsp. saprophyticus. To be Published 0 0 0 0 3C4A Crystal structure of vioD hydroxylase in complex with FAD from Chromobacterium violaceum. Northeast Structural Genomics Consortium Target CvR158 2008-01-29 2008-02-05 Forouhar, F.,Neely, H.,Seetharaman, J.,Janjua, H.,Xiao, R.,Maglaqui, M.,Wang, H.,Baran, M.C.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of vioD hydroxylase in complex with FAD from Chromobacterium violaceum. To be Published 0 0 0 0 3BBT 18334220 crystal structure of the ErbB4 kinase in complex with lapatinib 2007-11-11 2008-02-12 Qiu, C.,Tarrant, M.K.,Choi, S.H.,Sathyamurthy, A.,Bose, R.,Banjade, S.,Pal, A.,Bornmann, W.G.,Lemmon, M.A.,Cole, P.A.,Leahy, D.J. Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase. Structure 2008 16 460 467 3BCE 18334220 Crystal structure of the ErbB4 kinase 2007-11-12 2008-02-12 Qiu, C.,Tarrant, M.K.,Choi, S.H.,Sathyamurthy, A.,Bose, R.,Banjade, S.,Pal, A.,Bornmann, W.G.,Lemmon, M.A.,Cole, P.A.,Leahy, D.J. Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase. Structure 2008 16 460 467 3C37 X-ray structure of the putative Zn-dependent peptidase Q74D82 at the resolution 1.7 A. Northeast Structural Genomics Consortium target GsR143A 2008-01-27 2008-02-12 Kuzin, A.P.,Chen, Y.,Seetharaman, J.,Vorobiev, S.M.,Forouhar, F.,Wang, D.,Mao, L.,Maglaqui, M.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. X-ray structure of the putative Zn-dependent peptidase Q74D82 at the resolution 1.7 A. To be Published 0 0 0 0 3C4S Crystal structure of the Ssl0352 protein from Synechocystis sp. Northeast Structural Genomics Consortium target SgR42 2008-01-30 2008-02-12 Vorobiev, S.M.,Chen, Y.,Seetharaman, J.,Wang, D.,Maglaqui, M.,Janjua, H.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the Ssl0352 protein from Synechocystis sp. To be Published 0 0 0 0 3BL8 18250328 Crystal structure of the extracellular domain of neuroligin 2A from mouse 2007-12-10 2008-02-19 Koehnke, J.,Jin, X.,Budreck, E.C.,Posy, S.,Scheiffele, P.,Honig, B.,Shapiro, L. Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proc.Natl.Acad.Sci.Usa 2008 105 1873 1878 3C0D Crystal structure of the putative nitrite reductase NADPH (small subunit) oxidoreductase protein Q87HB1. Northeast Structural Genomics Consortium target VpR162 2008-01-19 2008-03-04 Kuzin, A.P.,Abashidze, M.,Seetharaman, J.,Vorobiev, S.M.,Wang, D.,Fang, Y.,Owens, L.,Ma, L.-C.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the putative nitrite reductase NADPH (small subunit) oxidoreductase protein Q87HB1. To be Published 0 0 0 0 3CAX Crystal structure of uncharacterized protein PF0695 2008-02-20 2008-03-18 Ramagopal, U.A.,Hu, S.,Toro, R.,Gilmore, M.,Bain, K.,Meyer, A.J.,Rodgers, L.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of uncharacterized protein PF0695. To be Published 0 0 0 0 3CE2 Crystal structure of putative peptidase from Chlamydophila abortus 2008-02-28 2008-03-18 Ramagopal, U.A.,Toro, R.,Gilmore, M.,Eberle, M.,Maletic, M.,Meyer, A.J.,Rodgers, L.,Sauder, J.M.,Burley, S.K.,Almo, S.C. Crystal structure of putative peptidase from Chlamydophila abortus. To be Published 0 0 0 0 3BOD 18334216 Structure of mouse beta-neurexin 1 2007-12-17 2008-03-25 Koehnke, J.,Jin, X.,Trbovic, N.,Katsamba, P.S.,Brasch, J.,Ahlsen, G.,Scheiffele, P.,Honig, B.,Palmer, A.G.,Shapiro, L. Crystal Structures of beta-Neurexin 1 and beta-Neurexin 2 Ectodomains and Dynamics of Splice Insertion Sequence 4. Structure 2008 16 410 421 3BOP 18334216 Structure of mouse beta-neurexin 2D4 2007-12-17 2008-03-25 Koehnke, J.,Jin, X.,Trbovic, N.,Katsamba, P.S.,Brasch, J.,Ahlsen, G.,Scheiffele, P.,Honig, B.,Palmer, A.G.,Shapiro, L. Crystal Structures of beta-Neurexin 1 and beta-Neurexin 2 Ectodomains and Dynamics of Splice Insertion Sequence 4. Structure 2008 16 410 421 3CEW Crystal structure of a cupin protein (BF4112) from Bacteroides fragilis. Northeast Structural Genomics Consortium target BfR205 2008-02-29 2008-03-25 Forouhar, F.,Chen, Y.,Seetharaman, J.,Mao, L.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Maglaqui, M.,Wang, H.,Baran, M.C.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of a cupin protein (BF4112) from Bacteroides fragilis. Northeast Structural Genomics Consortium target BfR205. To be Published 0 0 0 0 3BSX 18328718 Crystal Structure of Human Pumilio 1 in complex with Puf5 RNA 2007-12-26 2008-04-08 Gupta, Y.K.,Nair, D.T.,Wharton, R.P.,Aggarwal, A.K. Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure 2008 16 549 557 3CWI Crystal structure of thiamine biosynthesis protein (ThiS) from Geobacter metallireducens. Northeast Structural Genomics Consortium Target GmR137 2008-04-21 2008-05-06 Forouhar, F.,Abashidze, M.,Seetharaman, J.,Mao, L.,Janjua, H.,Xiao, R.,Maglaqui, M.,Ciccosanti, C.,Foote, E.L.,Wang, H.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of thiamine biosynthesis protein (ThiS) from Geobacter metallireducens. To be Published 0 0 0 0 3D0W Crystal structure of YflH protein from Bacillus subtilis. Northeast Structural Genomics Consortium target SR326 2008-05-02 2008-05-20 Seetharaman, J.,Kuzin, A.P.,Neely, H.,Forouhar, F.,Min, S.,Zhao, L.,Fang, Y.,Owens, L.,Ma, L.-C.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of YflH protein from Bacillus subtilis. To be Published 0 0 0 0 3D3N Crystal structure of lipase/esterase (lp_2923) from Lactobacillus plantarum. Northeast Structural Genomics Consortium target LpR108 2008-05-12 2008-06-10 Forouhar, F.,Su, M.,Seetharaman, J.,Mao, L.,Janjua, H.,Xiao, R.,Ciccosanti, C.,Maglaqui, M.,Foote, E.L.,Zhao, L.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of lipase/esterase (lp_2923) from Lactobacillus plantarum. Northeast Structural Genomics Consortium target LpR108 To be Published 0 0 0 0 3D3Q Crystal structure of tRNA delta(2)-isopentenylpyrophosphate transferase (SE0981) from Staphylococcus epidermidis. Northeast Structural Genomics Consortium target SeR100 2008-05-12 2008-07-15 Forouhar, F.,Abashidze, M.,Seetharaman, J.,Mao, L.,Xiao, R.,Maglaqui, M.,Lee, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of tRNA delta(2)-isopentenylpyrophosphate transferase (SE0981) from Staphylococcus epidermidis. To be Published 0 0 0 0 3D3U Crystal structure of 4-hydroxybutyrate CoA-transferase (abfT-2) from Porphyromonas gingivalis. Northeast Structural Genomics Consortium target PgR26 2008-05-12 2008-07-15 Forouhar, F.,Neely, H.,Zhang, X.-Z.,Price II, W.N.,Hussain, M.,Seetharaman, J.,Xiao, R.,Conover, K.,Cunningham, K.,Ma, L.-C.,Ho, C.K.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of 4-hydroxybutyrate CoA-transferase (abfT-2) from Porphyromonas gingivalis. To be Published 0 0 0 0 3DMF 18667428 T. Thermophilus 16S rRNA N2 G1207 methyltransferase (RsmC) in complex with AdoMet 2008-07-01 2008-07-29 Demirci, H.,Gregory, S.T.,Dahlberg, A.E.,Jogl, G. Crystal Structure of the Thermus thermophilus 16 S rRNA Methyltransferase RsmC in Complex with Cofactor and Substrate Guanosine. J.Biol.Chem. 2008 283 26548 26556 3DMG 18667428 T. Thermophilus 16S rRNA N2 G1207 methyltransferase (RsmC) in complex with AdoHcy 2008-07-01 2008-07-29 Demirci, H.,Gregory, S.T.,Dahlberg, A.E.,Jogl, G. Crystal Structure of the Thermus thermophilus 16 S rRNA Methyltransferase RsmC in Complex with Cofactor and Substrate Guanosine. J.Biol.Chem. 2008 283 26548 26556 3DMH 18667428 T. Thermophilus 16S rRNA N2 G1207 methyltransferase (RsmC) in complex with AdoMet and Guanosine 2008-07-01 2008-07-29 Demirci, H.,Gregory, S.T.,Dahlberg, A.E.,Jogl, G. Crystal Structure of the Thermus thermophilus 16 S rRNA Methyltransferase RsmC in Complex with Cofactor and Substrate Guanosine. J.Biol.Chem. 2008 283 26548 26556 3DEX Crystal structure of SAV_2001 protein from Streptomyces avermitilis, Northeast Structural Genomics Consortium Target SvR107. 2008-06-10 2008-08-05 Forouhar, F.,Neely, H.,Seetharaman, J.,Janjua, H.,Fang, Y.,Xiao, R.,Cunningham, K.,Ma, L.-C.,Owen, L.A.,Chen, C.X.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of SAV_2001 protein from Streptomyces avermitilis, Northeast Structural Genomics Consortium Target SvR107. To be Published 0 0 0 0 3DKZ Crystal structure of the Q7W9W5_BORPA protein from Bordetella parapertussis. Northeast Structural Genomics Consortium target BpR208C. 2008-06-26 2008-08-26 Vorobiev, S.M.,Su, M.,Seetharaman, J.,Wang, D.,Ciccosanti, C.,Foote, E.L.,Mao, L.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the Q7W9W5_BORPA protein from Bordetella parapertussis. To be Published 0 0 0 0 3DL3 Crystal structure of the tellurite resistance protein TehB. Northeast Structural Genomics Consortium target VfR98 . 2008-06-26 2008-08-26 Kuzin, A.P.,Su, M.,Seetharaman, J.,Wang, D.,Mao, L.,Maglaqui, M.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the tellurite resistance protein TehB. Northeast Structural Genomics Consortium target VfR98. To be Published 0 0 0 0 3E8P Crystal structure of the protein Q8E9M7 from Shewanella oneidensis related to thioesterase superfamily. Northeast Structural Genomics Consortium target SoR246. 2008-08-20 2008-09-02 Kuzin, A.P.,Abashidze, M.,Seetharaman, J.,Janjua, H.,Ciccosanti, C.,Foote, E.L.,Wang, H.,Xiao, R.,Nair, R.,Everett, J.,Acton, T.B.,Rost, B.,Tong, S.N.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the protein Q8E9M7 from Shewanella oneidensis related to thioesterase superfamily. Northeast Structural Genomics Consortium target SoR246. To be Published 0 0 0 0 3DQP Crystal structure of the oxidoreductase ylbE from Lactococcus lactis, Northeast Structural Genomics Consortium Target KR121. 2008-07-09 2008-09-09 Forouhar, F.,Neely, H.,Seetharaman, J.,Mao, L.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Lee, D.,Everett, J.K.,B Acton, T.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the oxidoreductase ylbE from Lactococcus lactis, Northeast Structural Genomics Consortium Target KR121. To be Published 0 0 0 0 3D1M 18794898 Crystal Structure of Sonic Hedgehog Bound to the third FNIII domain of CDO 2008-05-06 2008-09-23 McLellan, J.S.,Zheng, X.,Hauk, G.,Ghirlando, R.,Beachy, P.A.,Leahy, D.J. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature 2008 455 979 983 3EB4 18806782 Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone 2008-08-26 2008-09-23 Pan, Y.,Weng, J.,Kabaleeswaran, V.,Li, H.,Cao, Y.,Bhosle, R.C.,Zhou, M. Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nat.Chem.Biol. 2008 4 708 714 3E0E Crystal structure of a domain of replication protein A from Methanococcus maripaludis. NorthEast Structural Genomics targe MrR110B 2008-07-31 2008-09-30 Seetharaman, J.,Chen, Y.,Wang, H.,Janjua, H.,Foote, E.L.,Xiao, R.,Nair, R.,Everett, J.K.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of a domain of replication protein A from Methanococcus maripaludis. NorthEast Structural Genomics targe MrR110B To be Published 0 0 0 0 3ELI Crystal structure of the AHSA1 (SPO3351) protein from Silicibacter pomeroyi, Northeast Structural Genomics Consortium Target SiR160 2008-09-22 2008-09-30 Forouhar, F.,Su, M.,Seetharaman, J.,Janjua, H.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Wang, D.,Tong, S.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the AHSA1 (SPO3351) protein from Silicibacter pomeroyi, Northeast Structural Genomics Consortium Target SiR160 To be Published 0 0 0 0 3CK4 18804028 A heterospecific leucine zipper tetramer 2008-03-14 2008-10-07 Deng, Y.,Liu, J.,Zheng, Q.,Li, Q.,Kallenbach, N.R.,Lu, M. A heterospecific leucine zipper tetramer. Chem.Biol. 2008 15 908 919 3ERJ Crystal structure of the peptidyl-tRNA hydrolase AF2095 from Archaeglobus fulgidis. Northeast Structural Genomics Consortium target GR4 2008-10-02 2008-10-14 Forouhar, F.,Su, M.,Seetharaman, J.,Conover, K.,Janjua, H.,Xiao, R.,Cunningham, K.,Ma, L.-C.,Cooper, B.,Baran, M.C.,Liu, J.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the peptidyl-tRNA hydrolase AF2095 from Archaeglobus fulgidis. Northeast Structural Genomics Consortium target GR4 To be Published 0 0 0 0 3DWH 18945682 Structural and Functional Analysis of SRA domain 2008-07-22 2008-10-21 Qian, C.,Li, S.,Jakoncic, J.,Zeng, L.,Walsh, M.J.,Zhou, M.M. Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1. J.Biol.Chem. 2008 283 34490 34494 3ESI Crystal structure of an uncharacterized protein from Erwinia carotovora subsp. atroseptica. Northeast Structural Genomics target EwR179 2008-10-06 2008-10-21 Seetharaman, J.,Lew, S.,Wang, H.,Janjua, H.,Foote, E.L.,Xiao, R.,Nair, R.,Everett, J.K.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of an uncharacterized protein from Erwinia carotovora subsp. atroseptica. Northeast Structural Genomics target EwR179 To be Published 0 0 0 0 3EXA Crystal structure of the full-length tRNA isopentenylpyrophosphate transferase (BH2366) from Bacillus halodurans, Northeast Structural Genomics Consortium target BhR41. 2008-10-16 2008-11-11 Forouhar, F.,Abashidze, M.,Neely, H.,Seetharaman, J.,Shastry, R.,Janjua, H.,Cunningham, K.,Ma, L.-C.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the full-length tRNA isopentenylpyrophosphate transferase (BH2366) from Bacillus halodurans, Northeast Structural Genomics Consortium target BhR41. To be Published 0 0 0 0 3EDY 19038967 Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1 2008-09-03 2008-11-18 Guhaniyogi, J.,Sohar, I.,Das, K.,Stock, A.M.,Lobel, P. Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis J.Biol.Chem. 2009 284 3985 3997 3F1T Crystal structure of the Q9I3C8_PSEAE protein from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium target PaR319a. 2008-10-28 2008-11-18 Vorobiev, S.M.,Chen, Y.,Abashidze, M.,Seetharaman, J.,Wang, D.,Foote, E.L.,Ciccosanti, C.,Mao, L.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the Q9I3C8_PSEAE protein from Pseudomonas aeruginosa. To be Published 0 0 0 0 3F2I Crystal structure of the alr0221 protein from Nostoc, Northeast Structural Genomics Consortium Target NsR422. 2008-10-29 2008-11-18 Forouhar, F.,Lew, S.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Foote, E.L.,Ciccosanti, C.,Belote, R.L.,Nair, R.,Everett, J.K.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the alr0221 protein from Nostoc, Northeast Structural Genomics Consortium Target NsR422. To be Published 0 0 0 0 3E9C Structure of a tryptic core fragment of TIGAR from Danio rerio 2008-08-21 2008-12-16 Li, H.,Jogl, G. TIGAR (TP53 induced glycolysis and apoptosis regulator) is a fructose-2,6- and fructose-1,6-bisphosphatase To be Published 0 0 0 0 3E9D Structure of full-length TIGAR from Danio rerio 2008-08-21 2008-12-16 Li, H.,Jogl, G. TIGAR (TP53 induced glycolysis and apoptosis regulator) is a fructose-2,6- and fructose-1,6-bisphosphatase To be Published 0 0 0 0 3E9E Structure of full-length H11A mutant form of TIGAR from Danio rerio 2008-08-21 2008-12-16 Li, H.,Jogl, G. TIGAR (TP53 induced glycolysis and apoptosis regulator) is a fructose-2,6- and fructose-1,6-bisphosphatase To be Published 0 0 0 0 3FHW Crystal structure of the protein priB from Bordetella parapertussis. Northeast Structural Genomics Consortium target BpR162. 2008-12-10 2008-12-30 Kuzin, A.P.,Neely, H.,Seetharaman, J.,Forouhar, F.,Wang, D.,Mao, L.,Maglaqui, M.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the protein priB from Bordetella parapertussis. Northeast Structural Genomics Consortium target BpR162. To be Published 0 0 0 0 3FIA Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e. 2008-12-11 2008-12-30 Vorobiev, S.M.,Chen, Y.,Seetharaman, J.,Devices, C.,Zhao, L.,Foote, E.L.,Ciccosanti, C.,Mao, L.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the EH 1 domain from human intersectin-1 protein. To be Published 0 0 0 0 3FER Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a. 2008-11-30 2009-01-06 Kuzin, A.P.,Abashidze, M.,Seetharaman, R.,Shastry, R.,Sahdev, S.,Ciccosanti, C.,Xiao, R.,Everett, J.K.,Huang, Y.,Acton, T.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of n-terminal actin-binding domain from human filamin b (tandem ch-domains). northeast structural genomics consortium target hr5571a. To be Published 0 0 0 0 3FIF Crystal structure of the ygdR protein from E.coli. Northeast Structural Genomics target ER382A. 2008-12-11 2009-01-06 Kuzin, A.P.,Su, M.,Seetharaman, J.,Rossi, P.,Chen, C.X.,Jiang, M.,Cunningham, K.,Ma, L.,Xiao, R.,Liu, J.C.,Baran, M.,Swapna, G.V.T.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the ygdR protein from E.coli. Northeast Structural Genomics target ER382A. To be Published 0 0 0 0 3FLH Crystal structure of lp_1913 protein from Lactobacillus plantarum,Northeast Structural Genomics Consortium Target LpR140B 2008-12-18 2009-01-13 Seetharaman, J.,Chen, Y.,Forouhar, F.,Sahdev, S.,Foote, E.L.,Ciccosanti, C.,Belote, R.L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of lp_1913 protein from Lactobacillus plantarum,Northeast Structural Genomics Consortium Target LpR140B To be Published 0 0 0 0 3FQD 19194460 Crystal Structure of the S. pombe Rat1-Rai1 Complex 2009-01-07 2009-02-03 Xiang, S.,Cooper-Morgan, A.,Jiao, X.,Kiledjian, M.,Manley, J.L.,Tong, L. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature 2009 458 784 788 3FQG 19194460 Crystal Structure of the S. pombe Rai1 2009-01-07 2009-02-03 Xiang, S.,Cooper-Morgan, A.,Jiao, X.,Kiledjian, M.,Manley, J.L.,Tong, L. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature 2009 458 784 788 3FQJ 19194460 Crystal Structure of the Mouse Dom3Z in Complex with GDP 2009-01-07 2009-02-03 Xiang, S.,Cooper-Morgan, A.,Jiao, X.,Kiledjian, M.,Manley, J.L.,Tong, L. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature 2009 458 784 788 3BRH Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide 2007-12-21 2009-02-17 Seidel, R.,Love, J.,Piserchio, A.,Cowburn, D. Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases To be Published 0 0 0 0 3G6S Crystal structure of the endonuclease/exonuclease/phosphatase (BVU_0621) from Bacteroides vulgatus. Northeast Structural Genomics Consortium Target BvR56D 2009-02-08 2009-02-17 Forouhar, F.,Lew, S.,Seetharaman, J.,Xiao, R.,Sahdev, S.,Foote, E.L.,Ciccosanti, C.,Wang, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the endonuclease/exonuclease/phosphatase (BVU_0621) from Bacteroides vulgatus. To be Published 0 0 0 0 3G8C 19213731 Crystal Structure of Biotin Carboxylase in Complex with Biotin, Bicarbonate, ADP and Mg Ion 2009-02-12 2009-03-03 Chou, C.Y.,Yu, L.P.,Tong, L. Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. J.Biol.Chem. 2009 284 11690 11697 3G9Q Crystal structure of the FhuD fold-family BSU3320, a periplasmic binding protein component of a Fep/Fec-like ferrichrome ABC transporter from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR577A 2009-02-13 2009-03-03 Forouhar, F.,Neely, H.,Seetharaman, J.,Janjua, H.,Mao, L.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Lee, D.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the FhuD fold-family BSU3320, a periplasmic binding protein component of a Fep/Fec-like ferrichrome ABC transporter from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR577A. To be Published 0 0 0 0 3GK5 Crystal structure of rhodanese-related protein (TVG0868615) from Thermoplasma volcanium, Northeast Structural Genomics Consortium Target TvR109A 2009-03-09 2009-03-24 Forouhar, F.,Su, M.,Seetharaman, J.,Mao, L.,Xiao, R.,Foote, E.L.,Ciccosanti, C.,Belote, R.L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of rhodanese-related protein (TVG0868615) from Thermoplasma volcanium, Northeast Structural Genomics Consortium Target TvR109A To be Published 0 0 0 0 3FUT 19285505 Apo-form of T. thermophilus 16S rRNA A1518 and A1519 methyltransferase (KsgA) in space group P21212 2009-01-14 2009-03-31 Demirci, H.,Belardinelli, R.,Seri, E.,Gregory, S.T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. J.Mol.Biol. 2009 388 271 282 3FUU 19285505 T. thermophilus 16S rRNA A1518 and A1519 methyltransferase (KsgA) in complex with Adenosine in space group P212121 2009-01-14 2009-03-31 Demirci, H.,Belardinelli, R.,Seri, E.,Gregory, S.T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. J.Mol.Biol. 2009 388 271 282 3FUV 19285505 Apo-form of T. thermophilus 16S rRNA A1518 and A1519 methyltransferase (KsgA) in space group P43212 2009-01-14 2009-03-31 Demirci, H.,Belardinelli, R.,Seri, E.,Gregory, S.T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. J.Mol.Biol. 2009 388 271 282 3FUW 19285505 T. thermophilus 16S rRNA A1518 and A1519 methyltransferase (KsgA) in complex with 5'-methylthioadenosine in space group P212121 2009-01-14 2009-03-31 Demirci, H.,Belardinelli, R.,Seri, E.,Gregory, S.T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. J.Mol.Biol. 2009 388 271 282 3FUX 19285505 T. thermophilus 16S rRNA A1518 and A1519 methyltransferase (KsgA) in complex with 5'-methylthioadenosine in space group P212121 2009-01-14 2009-03-31 Demirci, H.,Belardinelli, R.,Seri, E.,Gregory, S.T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. J.Mol.Biol. 2009 388 271 282 3GOC Crystal structure of the Endonuclease V (SAV1684) from Streptomyces avermitilis. Northeast Structural Genomics Consortium Target SvR196 2009-03-18 2009-03-31 Forouhar, F.,Abashidze, M.,Hussain, M.,Seetharaman, J.,Fang, F.,Xiao, R.,Cunningham, K.,Ma, L.,Owens, L.,Chen, C.X.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) Crystal structure of the Endonuclease V (SAV1684) from Streptomyces avermitilis. Northeast Structural Genomics Consortium Target SvR196. To be Published 0 0 0 0 3GUW Crystal Structure of the TatD-like Protein (AF1765) from Archaeoglobus fulgidus, Northeast Structural Genomics Consortium Target GR121 2009-03-30 2009-04-07 Forouhar, F.,Su, M.,Seetharaman, J.,Fang, F.,Xiao, R.,Cunningham, K.,Ma, L.,Zhao, L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target GR121 To be Published 0 0 0 0 3GVZ Crystal structure of the protein CV2077 from Chromobacterium violaceum. Northeast Structural Genomics Consortium Target CvR62 2009-03-31 2009-04-14 Forouhar, F.,Neely, H.,Seetharaman, J.,Fang, F.,Xiao, R.,Cunningham, K.,Maglaqui, M.,Owens, L.,Chen, C.X.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the Protein CV2077 from Chromobacterium violaceum. Northeast Structural Genomics Consortium Target CvR62. To be Published 0 0 0 0 3H2B Crystal structure of the SAM-dependent methyltransferase cg3271 from Corynebacterium glutamicum in complex with S-adenosyl-L-homocysteine and pyrophosphate. Northeast Structural Genomics Consortium Target CgR113A 2009-04-14 2009-04-28 Forouhar, F.,Lew, S.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Foote, E.L.,Ciccosanti, C.,Wang, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target CgR113A To be published 0 0 0 0 3DVT 18650427 Biochemical and structural characterization of the PAK1- LC8 interaction 2008-07-20 2009-05-12 Lightcap, C.M.,Sun, S.,Lear, J.D.,Rodeck, U.,Polenova, T.,Williams, J.C. Biochemical and structural characterization of the Pak1-LC8 interaction. J.Biol.Chem. 2008 283 27314 27324 3GWB Crystal structure of peptidase M16 inactive domain from Pseudomonas fluorescens. Northeast Structural Genomics target PlR293L 2009-03-31 2009-05-12 Seetharaman, J.,Chen, Y.,Fang, F.,Xiao, R.,Everett, J.K.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of peptidase M16 inactive domain from Pseudomonas fluorescens. Northeast Structural Genomics target PlR293L To be Published 0 0 0 0 3H72 19284989 Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA) in complex with NANA 2009-04-24 2009-05-12 Hsiao, Y.-S.,Parker, D.,Ratner, A.J.,Prince, A.,Tong, L. Crystal structures of respiratory pathogen neuraminidases Biochem.Biophys.Res.Commun. 2009 380 467 471 3H73 19284989 Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA) in complex with DANA 2009-04-24 2009-05-12 Hsiao, Y.-S.,Parker, D.,Ratner, A.J.,Prince, A.,Tong, L. Crystal structures of respiratory pathogen neuraminidases Biochem.Biophys.Res.Commun. 2009 380 467 471 3DH9 Crystal Structure of Drosophila Thioredoxin Reductase, wild-type 2008-06-17 2009-06-16 Eckenroth, B.E.,Hondal, R.J.,Everse, S.J. Crystal Structure of Drosophila Thioredoxin Reductase, wild-type To be Published 0 0 0 0 3G88 19622680 T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group P61 2009-02-11 2009-06-30 Gregory, S.T.,Demirci, H.,Belardinelli, R.,Monshupanee, T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG Rna 2009 15 1693 1704 3G89 19622680 T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet and AMP in space group P61 2009-02-11 2009-06-30 Gregory, S.T.,Demirci, H.,Belardinelli, R.,Monshupanee, T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG Rna 2009 15 1693 1704 3G8A 19622680 T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoHcy in space group P61 2009-02-11 2009-06-30 Gregory, S.T.,Demirci, H.,Belardinelli, R.,Monshupanee, T.,Gualerzi, C.,Dahlberg, A.E.,Jogl, G. Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG Rna 2009 15 1693 1704 3HBL 19523900 Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant 2009-05-04 2009-06-30 Yu, L.P.,Xiang, S.,Lasso, G.,Gil, D.,Valle, M.,Tong, L. A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure 2009 17 823 832 3I1E Crystal Structure of the PDZ domain of the SdrC-like Protein (Lin2157) from Listeria innocua, Northeast Structural Genomics Consortium Target LkR136C 2009-06-26 2009-07-14 Forouhar, F.,Lew, S.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target LkR136C To be Published 0 0 0 0 3I1H Crystal structure of human BFL-1 in complex with BAK BH3 peptide 2009-06-26 2009-07-14 Guan, R.,Xiao, R.,Zhao, L.,Acton, T.,White, E.,Gelinas, C.,Montelione, G.T. crystal structure of human BFL-1 in complex with BAK BH3 peptide To be Published 0 0 0 0 3I3U Crystal structure of lp_1913 protein from lactobacillus plantarum, northeast structural genomics Consortium target lpr140a 2009-06-30 2009-07-21 Seetharaman, J.,Chen, Y.,Forouhar, F.,Sahdev, S.,Janjua, H.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of lp_1913 protein from lactobacillus plantarum, northeast structural genomics Consortium target lpr140a To be Published 0 0 0 0 3HRO 19556541 Crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2, polycystic kidney disease 2) 2009-06-09 2009-07-28 Yu, Y.,Ulbrich, M.H.,Li, M.H.,Buraei, Z.,Chen, X.Z.,Ong, A.C.,Tong, L.,Isacoff, E.Y.,Yang, J. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc.Natl.Acad.Sci.USA 2009 106 11558 11563 3IBW Crystal Structure of the ACT domain from GTP pyrophosphokinase of Chlorobium tepidum. Northeast Structural Genomics Consortium Target CtR148A 2009-07-17 2009-07-28 Vorobiev, S.,Su, M.,Seetharaman, J.,Janjua, J.,Xiao, R.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the ACT domain from GTP pyrophosphokinase of Chlorobium tepidum. To be Published 0 0 0 0 3IGN 22843345 Crystal Structure of the GGDEF domain from Marinobacter aquaeolei diguanylate cyclase complexed with c-di-GMP - Northeast Structural Genomics Consortium Target MqR89a 2009-07-28 2009-08-11 Vorobiev, S.M.,Neely, H.,Yu, B.,Seetharaman, J.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Hunt, J.F. Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product. J.Struct.Funct.Genom. 2012 13 177 183 3HKL 19664639 Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK 2009-05-24 2009-08-25 Stiegler, A.L.,Burden, S.J.,Hubbard, S.R. Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. J.Mol.Biol. 2009 393 1 9 3I2O 19706517 Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate and methylated trinucleotide T-meA-T 2009-06-29 2009-08-25 Yu, B.,Hunt, J.F. Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB. Proc.Natl.Acad.Sci.USA 2009 106 14315 14320 3I3Q 19706517 Crystal Structure of AlkB in complex with Mn(II) and 2-oxoglutarate 2009-06-30 2009-08-25 Yu, B.,Hunt, J.F. Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB. Proc.Natl.Acad.Sci.USA 2009 106 14315 14320 3I49 19706517 Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate and methylated trinucleotide T-meC-T 2009-07-01 2009-08-25 Yu, B.,Hunt, J.F. Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB. Proc.Natl.Acad.Sci.USA 2009 106 14315 14320 3IPF Crystal structure of the Q251Q8_DESHY protein from Desulfitobacterium hafniense. Northeast Structural Genomics Consortium Target DhR8c. 2009-08-17 2009-09-15 Vorobiev, S.M.,Chen, Y.,Seetharaman, J.,Janjua, H.,Xiao, R.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Andre, I.,Rossi, P.,Kennedy, M.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the Q251Q8_DESHY protein from Desulfitobacterium hafniense. To be Published 0 0 0 0 3JT0 Crystal Structure of the C-terminal fragment (426-558) Lamin-B1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR5546A 2009-09-11 2009-09-22 Kuzin, A.,Abashidze, M.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Belote, R.L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target HR5546A To be Published 0 0 0 0 3JU6 19783784 Crystal Structure of Dimeric Arginine Kinase in Complex with AMPPNP and Arginine 2009-09-14 2009-09-29 Wu, X.,Ye, S.,Guo, S.,Yan, W.,Bartlam, M.,Rao, Z. Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity Faseb J. 2010 24 242 252 3JU6 19783784 Crystal Structure of Dimeric Arginine Kinase in Complex with AMPPNP and Arginine 2009-09-14 2009-09-29 Wu, X.,Ye, S.,Guo, S.,Yan, W.,Bartlam, M.,Rao, Z. Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity Faseb J. 2010 24 242 252 3I9Y 19748340 Crystal structure of the V. parahaemolyticus histidine kinase sensor TorS sensor domain 2009-07-13 2009-10-06 Moore, J.O.,Hendrickson, W.A. Structural analysis of sensor domains from the TMAO-responsive histidine kinase receptor TorS Structure 2009 17 1195 1204 3GI3 19356929 Crystal structure of a N-Phenyl-N'-Naphthylurea analog in complex with p38 MAP kinase 2009-03-05 2009-10-20 Cirillo, P.F.,Hickey, E.R.,Moss, N.,Breitfelder, S.,Betageri, R.,Fadra, T.,Gaenzler, F.,Gilmore, T.,Goldberg, D.R.,Kamhi, V.,Kirrane, T.,Kroe, R.R.,Madwed, J.,Moriak, M.,Netherton, M.,Pargellis, C.A.,Patel, U.R.,Qian, K.C.,Sharma, R.,Sun, S.,Swinamer, A.,Torcellini, C.,Takahashi, H.,Tsang, M.,Xiong, Z. Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors. Bioorg.Med.Chem.Lett. 2009 19 2386 2391 3KB1 Crystal Structure of the Nucleotide-binding protein AF_226 in complex with ADP from Archaeoglobus fulgidus, Northeast Structural Genomics Consortium Target GR157 2009-10-19 2009-10-27 Forouhar, F.,Lew, S.,Abashidze, M.,Seetharaman, J.,Mao, M.,Xiao, R.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target GR157 To be Published 0 0 0 0 3KA5 Crystal structure of Ribosome-associated protein Y (PSrp-1) from Clostridium acetobutylicum. Northeast Structural Genomics Consortium target id CaR123A 2009-10-18 2009-11-03 Seetharaman, J.,Neely, H.,Wang, D.,Janjua, H.,Cunningham, K.,Owens, L.,Xiao, R.,Liu, J.,Baran, M.C.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of Ribosome-associated protein Y (PSrp-1) from Clostridium acetobutylicum To be Published 0 0 0 0 3EAC 27819029 Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form. 2008-08-25 2009-11-10 Liu, D.,Cowburn, D. Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep 2016 2 33 43 3EAZ 27819029 Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant. 2008-08-26 2009-11-10 Liu, D.,Cowburn, D. Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep 2016 2 33 43 3GHE 19913488 Crystal structure of anti-HIV-1 Fab 537-10D in complex with V3 peptide MN 2009-03-03 2009-12-01 Burke, V.,Williams, C.,Sukumaran, M.,Kim, S.S.,Li, H.,Wang, X.H.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Structural basis of the cross-reactivity of genetically related human anti-HIV-1 mAbs: implications for design of V3-based immunogens Structure 2009 17 1538 1546 3LMA Crystal structure of the stage V sporulation protein AD (SpoVAD) from Bacillus licheniformis. Northeast Structural Genomics Consortium Target BiR6. 2010-01-29 2010-02-09 Vorobiev, S.,Ashok, S.,Seetharaman, J.,Belote, R.L.,Ciccosanti, C.,Patel, D.J.,Janjua, H.,Acton, T.B.,Xiao, R.,Everett, J.K.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the stage V sporulation protein AD (SpoVAD) from Bacillus licheniformis. To be Published 0 0 0 0 3LJX Crystal Structure of MmoQ Response regulator (fragment 20-298) from Methylococcus capsulatus str. Bath, Northeast Structural Genomics Consortium Target McR175G 2010-01-26 2010-02-16 Kuzin, A.,Scott, L.,Forouhar, F.,Abashidze, M.,Seetharaman, J.,Mao, M.,Xiao, R.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target McR175G To be published 2009 0 0 0 3LLQ Aquaporin structure from plant pathogen Agrobacterium Tumerfaciens 2010-01-29 2010-02-16 Liu, Q.,Hillerich, B.,Love, J.,NYCOMPS Aquaporin structure from plant pathogen Agrobacterium Tumerfaciens To be Published 0 0 0 0 3LM6 Crystal Structure of Stage V sporulation protein AD (spoVAD) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR525 2010-01-29 2010-02-16 Forouhar, F.,Su, M.,Seetharaman, J.,Fang, F.,Xiao, R.,Cunningham, K.,Ma, L.,Wang, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target SR525 To be Published 0 0 0 0 3K6F 20190755 Crystal structure of mouse T-cadherin EC1 2009-10-08 2010-03-02 Ciatto, C.,Bahna, F.,Zampieri, N.,Vansteenhouse, H.C.,Katsamba, P.S.,Ahlsen, G.,Harrison, O.J.,Brasch, J.,Jin, X.,Posy, S.,Vendome, J.,Ranscht, B.,Jessell, T.M.,Honig, B.,Shapiro, L. T-cadherin structures reveal a novel adhesive binding mechanism Nat.Struct.Mol.Biol. 2010 17 339 347 3LM8 Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677 2010-01-29 2010-03-23 Kuzin, A.,Abashidze, M.,Seetharaman, J.,Mao, M.,Xiao, R.,Foote, E.L.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target SR677 To be Published 0 0 0 0 3LYU Crystal Structure of the C-terminal domain (residues 83-215) of PF1911 hydrogenase from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR246A 2010-02-28 2010-03-23 Forouhar, F.,Abashidze, M.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Foote, E.L.,Ciccosanti, C.,Belote, R.L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target PfR246A To be Published 0 0 0 0 3LZ7 Crystal Structure of thioesterase HI1161 EC3.1.2.- from Haemophilus influenzae. Orthorombic crystal form. Northeast Structural Genomics Consortium Target IR63 2010-03-01 2010-03-23 Kuzin, A.,Min, S.,Seetharaman, J.,Janjua, J.,Xiao, R.,Foote, E.L.,Ciccosanti, C.,Cooper, B.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target IR63 To be Published 0 0 0 0 3M6U 20558545 Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group 43 2010-03-16 2010-03-31 Demirci, H.,Larsen, L.H.,Hansen, T.,Rasmussen, A.,Cadambi, A.,Gregory, S.T.,Kirpekar, F.,Jogl, G. Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna 2010 16 1584 1596 3M6V 20558545 Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P2 in complex with S-Adenosyl-L-Methionine 2010-03-16 2010-03-31 Demirci, H.,Larsen, L.H.,Hansen, T.,Rasmussen, A.,Cadambi, A.,Gregory, S.T.,Kirpekar, F.,Jogl, G. Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna 2010 16 1584 1596 3M6X 20558545 Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P21212 2010-03-16 2010-03-31 Demirci, H.,Larsen, L.H.,Hansen, T.,Rasmussen, A.,Cadambi, A.,Gregory, S.T.,Kirpekar, F.,Jogl, G. Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna 2010 16 1584 1596 3LLP 20393565 1.8 Angstrom human fascin 1 crystal structure 2010-01-29 2010-04-07 Chen, L.,Yang, S.,Jakoncic, J.,Zhang, J.J.,Huang, X.Y. Migrastatin analogues target fascin to block tumour metastasis. Nature 2010 464 1062 1066 3MA5 Crystal structure of the tetratricopeptide repeat domain protein Q2S6C5_SALRD from Salinibacter ruber. Northeast Structural Genomics Consortium Target SrR115c. 2010-03-23 2010-04-07 Vorobiev, S.,Neely, H.,Seetharaman, J.,Wang, H.,Foote, E.L.,Ciccosanti, C.,Mao, L.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the tetratricopeptide repeat domain protein Q2S6C5_SALRD from Salinibacter ruber. To be Published 0 0 0 0 3MEP Crystal Structure of ECA2234 protein from Erwinia carotovora, Northeast Structural Genomics Consortium Target EwR44 2010-03-31 2010-04-14 Seetharaman, J.,Abashidze, M.,Forouhar, F.,Mao, M.,Xiao, R.,Ciccosanti, C.,Wang, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target EwR44 To be Published 0 0 0 0 3MFB Crystal Structure of the S-type Pyocin domain of ECA1669 protein from Erwinia carotovora, Northeast Structural Genomics Consortium Target EwR82C 2010-04-01 2010-04-14 Forouhar, F.,Neely, H.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target EwR82C To be Published 0 0 0 0 3MEJ Crystal structure of putative transcriptional regulator ywtF from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR736 2010-03-31 2010-04-28 Kuzin, A.,Su, M.,Seetharaman, J.,Mao, M.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target SR736 To be Published 0 0 0 0 3MGD Crystal Structure of predicted acetyltransferase with acetyl-CoA from Clostridium acetobutylicum at the resolution 1.9A, Northeast Structural Genomics Consortium Target CaR165 2010-04-05 2010-04-28 Kuzin, A.,Chen, Y.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Zhao, L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target CaR165 To be published 0 0 0 0 3MJQ Crystal structure of the PAS domain of Q24QT8_DESHY protein from Desulfitobacterium hafniense. Northeast Structural Genomics Consortium Target DhR85c. 2010-04-13 2010-04-28 Vorobiev, S.,Neely, H.,Seetharaman, J.,Wang, D.,Ciccosanti, C.,Mao, L.,Xiao, R.,Acton, T.B.,Everett, J.K.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal structure of the PAS domain of Q24QT8_DESHY protein from Desulfitobacterium hafniense. To be Published 0 0 0 0 3MEL Crystal Structure of Thiamin pyrophosphokinase family protein from Enterococcus faecalis, Northeast Structural Genomics Consortium Target EfR150 2010-03-31 2010-05-05 Kuzin, A.,Abasidze, M.,Seetharaman, J.,Mao, M.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Maglaqui, M.,Zhao, L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target EfR150 To be Published 0 0 0 0 3LJW 20368734 Crystal Structure of the Second Bromodomain of Human Polybromo 2010-01-26 2010-05-19 Charlop-Powers, Z.,Zeng, L.,Zhang, Q.,Zhou, M.M. Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res. 2010 20 529 538 3GO1 20622876 Crystal structure of anti-HIV-1 Fab 268-D in complex with V3 peptide MN 2009-03-18 2010-06-23 Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat.Struct.Mol.Biol. 2010 17 955 961 3ML4 20603078 Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region 2010-04-16 2010-07-14 Bergamin, E.,Hallock, P.T.,Burden, S.J.,Hubbard, S.R. The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization. Mol.Cell 2010 39 100 109 3MLT 20622876 Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide 2010-04-18 2010-07-14 Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat.Struct.Mol.Biol. 2010 17 955 961 3MLW 20622876 Crystal structure of anti-HIV-1 V3 Fab 1006-15D in complex with an MN V3 peptide 2010-04-18 2010-07-14 Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat.Struct.Mol.Biol. 2010 17 955 961 3MLX 20622876 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with an MN V3 peptide 2010-04-18 2010-07-14 Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat.Struct.Mol.Biol. 2010 17 955 961 3MLY 20622876 Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with a UR29 V3 peptide 2010-04-18 2010-07-14 Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat.Struct.Mol.Biol. 2010 17 955 961 3MW2 20624592 Crystal structure of beta-neurexin 1 with the splice insert 4 2010-05-05 2010-07-28 Koehnke, J.,Katsamba, P.S.,Ahlsen, G.,Bahna, F.,Vendome, J.,Honig, B.,Shapiro, L.,Jin, X. Splice Form Dependence of beta-Neurexin/Neuroligin Binding Interactions. Neuron 2010 67 61 74 3MW4 20624592 Crystal structure of beta-neurexin 3 without the splice insert 4 2010-05-05 2010-07-28 Koehnke, J.,Katsamba, P.S.,Ahlsen, G.,Bahna, F.,Vendome, J.,Honig, B.,Shapiro, L.,Jin, X. Splice Form Dependence of beta-Neurexin/Neuroligin Binding Interactions. Neuron 2010 67 61 74 3NHV Crystal Structure of BH2092 protein from Bacillus halodurans, Northeast Structural Genomics Consortium Target BhR228F 2010-06-14 2010-08-11 Forouhar, F.,Neely, H.,Seetharaman, J.,Mao, M.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target BhR228F To be Published 2010 0 0 0 3NNG Crystal structure of the F5/8 type C domain of Q5LFR2_BACFN protein from Bacteroides fragilis. Northeast Structural Genomics Consortium Target BfR258E 2010-06-23 2010-08-18 Vorobiev, S.,Su, M.,Dimaio, F.,Baker, D.,Seetharaman, J.,Janjua, J.,Xiao, R.,Ciccosanti, C.,Foote, E.L.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of the F5/8 type C domain of Q5LFR2_BACFN protein from Bacteroides fragilis. To be Published 0 0 0 0 3NRL Crystal Structure of protein RUMGNA_01417 from Ruminococcus gnavus, Northeast Structural Genomics Consortium Target UgR76 2010-06-30 2010-08-25 Seetharaman, J.,Abashidze, M.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target UgR76 To be Published 0 0 0 0 3NZQ 21139196 Crystal Structure of Biosynthetic arginine decarboxylase ADC (SpeA) from Escherichia coli, Northeast Structural Genomics Consortium Target ER600 2010-07-16 2010-09-01 Forouhar, F.,Lew, S.,Seetharaman, J.,Xiao, R.,Acton, T.B.,Montelione, G.T.,Tong, L. Structures of bacterial biosynthetic arginine decarboxylases. Acta Crystallogr.,Sect.F 2010 66 1562 1566 3O3W Crystal Structure of BH2092 protein (residues 14-131) from Bacillus halodurans, Northeast Structural Genomics Consortium Target BhR228A 2010-07-26 2010-09-01 Forouhar, F.,Neely, H.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of BH2092 protein (residues 14-131) from Bacillus halodurans, Northeast Structural Genomics Consortium Target BhR228A To be Published 0 0 0 0 3MN3 20823513 An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1 2010-04-20 2010-09-15 Rudolph, M.J.,Amodeo, G.A.,Tong, L. An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1. Acta Crystallogr.,Sect.F 2010 66 999 1002 3OBH X-ray crystal structure of protein SP_0782 (7-79) from Streptococcus pneumoniae. Northeast Structural Genomics Consortium Target SpR104 2010-08-06 2010-09-15 Kuzin, A.,Abashidze, M.,Lew, S.,Seetharaman, J.,Patel, P.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. X-ray crystal structure of protein SP_0782 (7-79) from Streptococcus pneumoniae. Northeast Structural Genomics Consortium Target SpR104 To be Published 0 0 0 0 3O2S 20861839 Crystal structure of the human symplekin-Ssu72 complex 2010-07-22 2010-10-06 Xiang, K.,Nagaike, T.,Xiang, S.,Kilic, T.,Beh, M.M.,Manley, J.L.,Tong, L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature 2010 467 729 733 3OTF 20829353 Structural basis for the cAMP-dependent gating in human HCN4 channel 2010-09-11 2010-10-13 Xu, X.,Vysotskaya, Z.V.,Liu, Q.,Zhou, L. Structural basis for the cAMP-dependent gating in the human HCN4 channel. J.Biol.Chem. 2010 285 37082 37091 3P51 Three-dimensional structure of protein Q2Y8N9_NITMU from nitrosospira multiformis, Northeast structural genomics consortium target NMR118 2010-10-07 2010-10-27 Kuzin, A.,Chen, Y.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target NmR118 To be published 0 0 0 0 3P9V High Resolution Crystal Structure of protein Maqu_3174 from Marinobacter aquaeolei, Northeast Structural Genomics Consortium Target MqR197 2010-10-18 2010-10-27 Kuzin, A.,Chen, Y.,Seetharaman, J.,Mao, M.,Xiao, R.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target MqR197 To be published 0 0 0 0 3MIG 20958070 Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite, obtained in the presence of substrate 2010-04-10 2010-11-24 Chufan, E.E.,Prigge, S.T.,Siebert, X.,Eipper, B.A.,Mains, R.E.,Amzel, L.M. Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc. 2010 132 15565 15572 3MIH 20958070 Oxidized (Cu2+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide, obtained in the presence of substrate 2010-04-10 2010-11-24 Chufan, E.E.,Prigge, S.T.,Siebert, X.,Eipper, B.A.,Mains, R.E.,Amzel, L.M. Differential Reactivity Between the Two Copper Sites of Peptidylglycine alpha-Hydroxylating Monooxygenase (PHM) J.Am.Chem.Soc. 2010 132 15565 15572 3PM7 Crystal Structure of EF_3132 protein from Enterococcus faecalis at the resolution 2A, Northeast Structural Genomics Consortium Target EfR184 2010-11-16 2010-12-15 Kuzin, A.,Su, M.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) Northeast Structural Genomics Consortium Target EfR184 To be Published 0 0 0 0 3PU2 Crystal Structure of the Q3J4M4_RHOS4 protein from Rhodobacter sphaeroides. Northeast Structural Genomics Consortium Target RhR263. 2010-12-03 2010-12-15 Vorobiev, S.,Chen, Y.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Wang, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal Structure of the Q3J4M4_RHOS4 protein from Rhodobacter sphaeroides. To be Published 0 0 0 0 3PG5 Crystal structure of protein DIP2308 from Corynebacterium diphtheriae, Northeast Structural Genomics Consortium Target CdR78 2010-10-30 2010-12-22 Forouhar, F.,Lew, S.,Seetharaman, J.,Lee, D.,Ciccosanti, C.,Sahdev, S.,Nair, R.,Rost, B.,Acton, T.B.,Xiao, R.,Everett, J.K.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal structure of protein DIP2308 from Corynebacterium diphtheriae, Northeast Structural Genomics Consortium Target CdR78 To be Published 0 0 0 0 3PUT Crystal Structure of the CERT START domain (mutant V151E) from Rhizobium etli at the resolution 1.8A, Northeast Structural Genomics Consortium Target ReR239. 2010-12-06 2010-12-22 Kuzin, A.,Chen, Y.,Seetharaman, J.,Mao, M.,Xiao, R.,Ciccosanti, C.,Wang, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the CERT START domain (mutant V151E) from Rhizobium etli at the resolution 1.8A, Northeast Structural Genomics Consortium Target ReR239. To be Published 0 0 0 0 3PPE 21269602 Crystal structure of chicken VE-cadherin EC1-2 2010-11-24 2011-02-02 Brasch, J.,Harrison, O.J.,Ahlsen, G.,Carnally, S.M.,Henderson, R.M.,Honig, B.,Shapiro, L. Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. J.Mol.Biol. 2011 408 57 73 3Q2L 21300292 Mouse E-cadherin EC1-2 V81D mutant 2010-12-20 2011-02-23 Harrison, O.J.,Jin, X.,Hong, S.,Bahna, F.,Ahlsen, G.,Brasch, J.,Wu, Y.,Vendome, J.,Felsovalyi, K.,Hampton, C.M.,Troyanovsky, R.B.,Ben-Shaul, A.,Frank, J.,Troyanovsky, S.M.,Shapiro, L.,Honig, B. The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure 2011 19 244 256 3Q2N 21300292 Mouse E-cadherin EC1-2 L175D mutant 2010-12-20 2011-02-23 Harrison, O.J.,Jin, X.,Hong, S.,Bahna, F.,Ahlsen, G.,Brasch, J.,Wu, Y.,Vendome, J.,Felsovalyi, K.,Hampton, C.M.,Troyanovsky, R.B.,Ben-Shaul, A.,Frank, J.,Troyanovsky, S.M.,Shapiro, L.,Honig, B. The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure 2011 19 244 256 3Q2W 21300292 Crystal structure of mouse N-cadherin ectodomain 2010-12-20 2011-02-23 Harrison, O.J.,Jin, X.,Hong, S.,Bahna, F.,Ahlsen, G.,Brasch, J.,Wu, Y.,Vendome, J.,Felsovalyi, K.,Hampton, C.M.,Troyanovsky, R.B.,Ben-Shaul, A.,Frank, J.,Troyanovsky, S.M.,Shapiro, L.,Honig, B. The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure 2011 19 244 256 3MLK 20958070 Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound nitrite 2010-04-16 2011-03-02 Chufan, E.E.,Prigge, S.T.,Siebert, X.,Eipper, B.A.,Mains, R.E.,Amzel, L.M. Differential reactivity between two copper sites in peptidylglycine alpha-hydroxylating monooxygenase J.Am.Chem.Soc. 2010 132 15565 15572 3MLL 20958070 Reduced (Cu+) peptidylglycine alpha-hydroxylating monooxygenase (PHM) with bound azide 2010-04-16 2011-03-02 Chufan, E.E.,Prigge, S.T.,Siebert, X.,Eipper, B.A.,Mains, R.E.,Amzel, L.M. Differential reactivity between two copper sites in peptidylglycine alpha-hydroxylating monooxygenase J.Am.Chem.Soc. 2010 132 15565 15572 3OFF Structured Domain of Drosophila melanogaster Boca p65 2 2 Crystal form 2010-08-14 2011-03-02 Collins, M.N.,Hendrickson, W.A. Structural Characterization of the Boca/Mesd Maturation Factors for LDL-Receptor-Type beta-Propeller Domains Structure 2011 0 0 0 3OFG Structured Domain of Caenorhabditis elegans BMY-1 2010-08-14 2011-03-02 Collins, M.N.,Hendrickson, W.A. Structural Characterization of the Boca/Mesd Maturation Factors for LDL-Receptor-Type beta-Propeller Domains Structure 2011 0 0 0 3OFH Structured Domain of Mus musculus Mesd 2010-08-14 2011-03-02 Collins, M.N.,Hendrickson, W.A. Structural Characterization of the Boca/Mesd Maturation Factors for LDL-Receptor-Type beta-Propeller Domains Structure 2011 0 0 0 3QFI X-ray crystal structure of transcriptional regulator (EF0465) from Enterococcus faecalis, Northeast Structural Genomics Consortium Target EfR190 2011-01-21 2011-03-02 Forouhar, F.,Neely, H.,Seetharaman, J.,Wang, H.,Ciccosanti, C.,Mao, L.,Acton, T.B.,Xiao, R.,Everett, J.K.,Montelione, G.T.,Tong, L.,Hun, J.F.,Northeast Structural Genomics Consortium (NESG) X-ray crystal structure of transcriptional regulator (EF0465) from Enterococcus faecalis, Northeast Structural Genomics Consortium Target EfR190 To be Published 0 0 0 0 3RK0 22102225 X-ray crystal Structure of the putative N-type ATP pyrophosphatase (PF0828) in complex with AMP from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR23 2011-04-16 2011-05-11 Forouhar, F.,Saadat, N.,Hussain, M.,Seetharaman, J.,Lee, I.,Janjua, H.,Xiao, R.,Shastry, R.,Acton, T.B.,Montelione, G.T.,Tong, L. A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding. Acta Crystallogr.,Sect.F 2011 67 1323 1327 3Q6F 21565703 Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120 2010-12-31 2011-05-25 Spurrier, B.,Sampson, J.M.,Totrov, M.,Li, H.,O'Neal, T.,Williams, C.,Robinson, J.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P. Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120. Structure 2011 19 691 699 3RQS Crystal Structure of human L-3- Hydroxyacyl-CoA dehydrogenase (EC1.1.1.35) from mitochondria at the resolution 2.0 A, Northeast Structural Genomics Consortium Target HR487, Mitochondrial Protein Partnership 2011-04-28 2011-05-25 Kuzin, A.,Su, M.,Seetharaman, J.,Patel, P.,Xiao, R.,Ciccosanti, C.,Shastry, R.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target HR487 To be published 0 0 0 0 3R66 Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza virus B, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2 2011-03-21 2011-06-08 Guan, R.,Ma, L.C.,Leonard, P.G.,Brendan, A.R.,Sridharan, H.,Zhao, C.,Krug, R.M.,Montelione, G.T. The Structure of the complex of ISG15 and Influenza B virus NS1 Protein: implications for the mechanism of SN1-mediated inhibition of ISG15 conjugation To be Published 0 0 0 0 3RRU X-ray crystal structure of the VHS domain of human TOM1-like protein, Northeast Structural Genomics Consortium Target HR3050E 2011-04-30 2011-06-08 Forouhar, F.,Lew, S.,Seetharaman, J.,Wang, H.,Ciccosanti, C.,Patel, D.,Acton, T.B.,Xiao, R.,Everett, J.K.,Montelione, G.T.,Hunt, J.F.,Tong, L. X-ray crystal structure of the VHS domain of human TOM1-like protein, Northeast Structural Genomics Consortium Target HR3050E To be Published 0 0 0 0 3N27 Molecular Basis of the Inhibition of Henipa Viruses 2010-05-17 2011-06-29 Liu, J.,Lu, M. Molecular Basis of the Inhibition of Henipa Viruses To be Published 0 0 0 0 3SDL 21808041 Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza B virus, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2 2011-06-09 2011-07-20 Guan, R.,Ma, L.C.,Leonard, P.G.,Amer, B.R.,Sridharan, H.,Zhao, C.,Krug, R.M.,Montelione, G.T. Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus. Proc.Natl.Acad.Sci.USA 2011 108 13468 13473 3SM3 Crystal Structure of SAM-dependent methyltransferases Q8PUK2_METMA from Methanosarcina mazei. Northeast Structural Genomics Consortium Target MaR262. 2011-06-27 2011-07-20 Vorobiev, S.,Neely, H.,Seetharaman, J.,Snyder, A.,Patel, P.,Xiao, R.,Ciccosanti, C.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal Structure of SAM-dependent methyltransferases Q8PUK2_METMA from Methanosarcina mazei. To be Published 2009 0 0 0 3SXW Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR69. 2011-07-15 2011-08-03 Vorobiev, S.,Su, M.,Nivon, L.,Seetharaman, J.,Patel, P.,Xiao, R.,Maglaqui, M.,Ciccosanti, C.,Baker, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR69. To be Published 0 0 0 0 3SY1 Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70 2011-07-15 2011-08-03 Vorobiev, S.,Su, M.,Nivon, L.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Maglaqui, M.,Baker, D.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70 To be Published 0 0 0 0 3S37 21827946 Structural basis for the function of two anti-VEGF receptor antibodies 2011-05-17 2011-08-24 Franklin, M.C.,Navarro, E.C.,Wang, Y.,Patel, S.,Singh, P.,Zhang, Y.,Persaud, K.,Bari, A.,Griffith, H.,Shen, L.,Balderes, P.,Kussie, P. The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies. Structure 2011 19 1097 1107 3TC6 24161950 Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR63. 2011-08-08 2011-08-24 Bjelic, S.,Kipnis, Y.,Wang, L.,Pianowski, Z.,Vorobiev, S.,Su, M.,Seetharaman, J.,Xiao, R.,Kornhaber, G.,Hunt, J.F.,Tong, L.,Hilvert, D.,Baker, D. Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J.Mol.Biol. 2014 426 256 271 3TC7 24161950 Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62. 2011-08-08 2011-08-24 Bjelic, S.,Kipnis, Y.,Wang, L.,Pianowski, Z.,Vorobiev, S.,Su, M.,Seetharaman, J.,Xiao, R.,Kornhaber, G.,Hunt, J.F.,Tong, L.,Hilvert, D.,Baker, D. Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J.Mol.Biol. 2014 426 256 271 3R2P 21914797 2.2 Angstrom Crystal Structure of C Terminal Truncated Human Apolipoprotein A-I Reveals the Assembly of HDL by Dimerization. 2011-03-14 2011-09-21 Mei, X.,Atkinson, D. Crystal Structure of C-terminal Truncated Apolipoprotein A-I Reveals the Assembly of High Density Lipoprotein (HDL) by Dimerization. J.Biol.Chem. 2011 286 38570 38582 3TQC 26033498 Structure of the pantothenate kinase (coaA) from Coxiella burnetii 2011-09-09 2011-09-21 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQE 26033498 Structure of the malonyl CoA-acyl carrier protein transacylase (fabD) from Coxiella burnetii 2011-09-09 2011-09-21 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQF 26033498 Structure of the Hpr(Ser) kinase/phosphatase from Coxiella burnetii 2011-09-09 2011-09-21 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQK 23704901 Structure of Phospho-2-dehydro-3-deoxyheptonate aldolase from Francisella tularensis SCHU S4 2011-09-09 2011-09-21 Chaudhury, S.,Abdulhameed, M.D.,Singh, N.,Tawa, G.J.,D'haeseleer, P.M.,Zemla, A.T.,Navid, A.,Zhou, C.E.,Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Love, J.,Graf, J.F.,Rozak, D.A.,Dankmeyer, J.L.,Amemiya, K.,Daefler, S.,Wallqvist, A. Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction. Plos One 2013 8 0 0 3TQX 26033498 Structure of the 2-amino-3-ketobutyrate coenzyme A ligase (kbl) from Coxiella burnetii 2011-09-09 2011-09-21 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQY 26033498 Structure of a single-stranded DNA-binding protein (ssb), from Coxiella burnetii 2011-09-09 2011-09-21 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TRD 26033498 Structure of an alpha-beta serine hydrolase homologue from Coxiella burnetii 2011-09-09 2011-09-21 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TRF 26033498 Structure of a shikimate kinase (aroK) from Coxiella burnetii 2011-09-09 2011-09-21 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQG 26033498 Structure of the 2-methylcitrate synthase (prpC) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQH 26033498 Structure of the quinone oxidoreductase from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQN 26033498 Structure of the transcriptional regulator of the GntR family, from Coxiella burnetii. 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQO 26033498 Structure of the cysteinyl-tRNA synthetase (cysS) from Coxiella burnetii. 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQR 26033498 Structure of the phosphoribosylglycinamide formyltransferase (purN) in complex with CHES from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQS 26033498 Structure of the dimethyladenosine transferase (ksgA) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQT 26033498 Structure of the D-alanine-D-alanine ligase from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQV 23704901 Structure of the nicotinate-nucleotide pyrophosphorylase from Francisella tularensis. 2011-09-09 2011-09-28 Chaudhury, S.,Abdulhameed, M.D.,Singh, N.,Tawa, G.J.,D'haeseleer, P.M.,Zemla, A.T.,Navid, A.,Zhou, C.E.,Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Love, J.,Graf, J.F.,Rozak, D.A.,Dankmeyer, J.L.,Amemiya, K.,Daefler, S.,Wallqvist, A. Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction. Plos One 2013 8 0 0 3TR1 26033498 Structure of a 3-phosphoshikimate 1-carboxyvinyltransferase (aroA) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TR3 26033498 Structure of a bolA protein homologue from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TRH 26033498 Structure of a phosphoribosylaminoimidazole carboxylase catalytic subunit (purE) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TRI 26033498 Structure of a pyrroline-5-carboxylate reductase (proC) from Coxiella burnetii 2011-09-09 2011-09-28 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TP4 24705591 Crystal Structure of engineered protein at the resolution 1.98A, Northeast Structural Genomics Consortium Target OR128 2011-09-07 2011-10-05 Rajagopalan, S.,Wang, C.,Yu, K.,Kuzin, A.P.,Richter, F.,Lew, S.,Miklos, A.E.,Matthews, M.L.,Seetharaman, J.,Su, M.,Hunt, J.F.,Cravatt, B.F.,Baker, D. Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol. 2014 10 386 391 3TQL 26033498 Structure of the amino acid ABC transporter, periplasmic amino acid-binding protein from Coxiella burnetii. 2011-09-09 2011-10-05 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TR4 26033498 Structure of an inorganic pyrophosphatase (ppa) from Coxiella burnetii 2011-09-09 2011-10-19 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3U1O 22871159 THREE DIMENSIONAL STRUCTURE OF DE NOVO DESIGNED CYSTEINE ESTERASE ECH19, Northeast Structural Genomics Consortium Target OR49 2011-09-30 2011-10-26 Richter, F.,Blomberg, R.,Khare, S.D.,Kiss, G.,Kuzin, A.P.,Smith, A.J.,Gallaher, J.,Pianowski, Z.,Helgeson, R.C.,Grjasnow, A.,Xiao, R.,Seetharaman, J.,Su, M.,Vorobiev, S.,Lew, S.,Forouhar, F.,Kornhaber, G.J.,Hunt, J.F.,Montelione, G.T.,Tong, L.,Houk, K.N.,Hilvert, D.,Baker, D. Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J.Am.Chem.Soc. 2012 134 16197 16206 3THP 22065580 Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B 2011-08-19 2011-11-02 Pastore, C.,Topalidou, I.,Forouhar, F.,Yan, A.C.,Levy, M.,Hunt, J.F. Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. J.Biol.Chem. 2012 287 2130 2143 3TQ8 26033498 Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim 2011-09-09 2011-11-02 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQ9 26033498 Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with methotrexate 2011-09-09 2011-11-02 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQA 26033498 Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with NADPH 2011-09-09 2011-11-02 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TQB 26033498 Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with folate 2011-09-09 2011-11-02 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TTH 26033498 Structure of the spermidine N1-acetyltransferase (speG) from Coxiella burnetii 2011-09-14 2011-11-09 Franklin, M.C.,Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.,Gary, E.,Hillerich, B.,Yao, Z.K.,Carlier, P.R.,Totrov, M.,Love, J.D. Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins 2015 83 2124 2136 3TX3 CysZ, a putative sulfate permease 2011-09-22 2011-11-09 Assur, Z.,Liu, Q.,Hendrickson, W.A.,Mancia, F. CysZ, a putative sulfate permease To be Published 0 0 0 0 3UAK 22871159 Crystal Structure of De Novo designed cysteine esterase ECH14, Northeast Structural Genomics Consortium Target OR54 2011-10-21 2011-12-07 Richter, F.,Blomberg, R.,Khare, S.D.,Kiss, G.,Kuzin, A.P.,Smith, A.J.,Gallaher, J.,Pianowski, Z.,Helgeson, R.C.,Grjasnow, A.,Xiao, R.,Seetharaman, J.,Su, M.,Vorobiev, S.,Lew, S.,Forouhar, F.,Kornhaber, G.J.,Hunt, J.F.,Montelione, G.T.,Tong, L.,Houk, K.N.,Hilvert, D.,Baker, D. Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J.Am.Chem.Soc. 2012 134 16197 16206 3USH Crystal Structure of the Q2S0R5 protein from Salinibacter ruber, Northeast Structural Genomics Consortium Target SrR207 2011-11-23 2011-12-14 Vorobiev, S.,Su, M.,Seetharaman, J.,Maglaqui, M.,Xiao, R.,Kohan, E.,Wang, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the Q2S0R5 protein from Salinibacter ruber, Northeast Structural Genomics Consortium Target SrR207 To be Published 0 0 0 0 3O1I 22483119 Crystal Structure of the TorS sensor domain - TorT complex in the absence of ligand 2010-07-21 2011-12-21 Moore, J.O.,Hendrickson, W.A. An asymmetry-to-symmetry switch in signal transmission by the histidine kinase receptor for TMAO. Structure 2012 20 729 741 3O1J 22483119 Crystal Structure of the TorS sensor domain - TorT complex in the absence of isopropanol 2010-07-21 2011-12-21 Moore, J.O.,Hendrickson, W.A. An asymmetry-to-symmetry switch in signal transmission by the histidine kinase receptor for TMAO. Structure 2012 20 729 741 3UBF 22171007 Crystal structure of Drosophila N-cadherin EC1-3, I 2011-10-24 2011-12-21 Jin, X.,Walker, M.A.,Felsovalyi, K.,Vendome, J.,Bahna, F.,Mannepalli, S.,Cosmanescu, F.,Ahlsen, G.,Honig, B.,Shapiro, L. Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers. Proc.Natl.Acad.Sci.USA 2012 109 0 0 3UBG 22171007 Crystal structure of Drosophila N-cadherin EC1-3, II 2011-10-24 2011-12-21 Jin, X.,Walker, M.A.,Felsovalyi, K.,Vendome, J.,Bahna, F.,Mannepalli, S.,Cosmanescu, F.,Ahlsen, G.,Honig, B.,Shapiro, L. Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers. Proc.Natl.Acad.Sci.USA 2012 109 0 0 3UBH 22171007 Crystal structure of Drosophila N-cadherin EC1-4 2011-10-24 2011-12-21 Jin, X.,Walker, M.A.,Felsovalyi, K.,Vendome, J.,Bahna, F.,Mannepalli, S.,Cosmanescu, F.,Ahlsen, G.,Honig, B.,Shapiro, L. Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers. Proc.Natl.Acad.Sci.USA 2012 109 0 0 3UJI 22164215 Crystal structure of anti-HIV-1 V3 Fab 2558 in complex with MN peptide 2011-11-07 2011-12-28 Gorny, M.K.,Sampson, J.,Li, H.,Jiang, X.,Totrov, M.,Wang, X.H.,Williams, C.,O'Neal, T.,Volsky, B.,Li, L.,Cardozo, T.,Nyambi, P.,Zolla-Pazner, S.,Kong, X.P. Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure. Plos One 2011 6 0 0 3UJJ 22164215 Crystal structure of anti-HIV-1 V3 Fab 4025 in complex with Con A peptide 2011-11-07 2011-12-28 Gorny, M.K.,Sampson, J.,Li, H.,Jiang, X.,Totrov, M.,Wang, X.H.,Williams, C.,O'Neal, T.,Volsky, B.,Li, L.,Cardozo, T.,Nyambi, P.,Zolla-Pazner, S.,Kong, X.P. Human Anti-V3 HIV-1 Monoclonal Antibodies Encoded by the VH5-51/VL Lambda Genes Define a Conserved Antigenic Structure. Plos One 2011 6 0 0 4DMB X-ray structure of human hepatitus C virus NS5A-transactivated protein 2 at the resolution 1.9A, Northeast Structural Genomics Consortium (NESG) Target HR6723 2012-02-07 2012-04-04 Kuzin, A.,Su, M.,Seetharaman, J.,Patel, P.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target HR6723 To be Published 0 0 0 0 4DIU Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR94 2012-01-31 2012-04-11 Seetharaman, J.,Lew, S.,Wang, D.,Kohan, E.,Patel, D.,Whitehead, T.,Fleishman, S.,Ciccosanti, C.,Xiao, R.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR94 To be Published 0 0 0 0 4EVW Crystal Structure of the nucleoside-diphosphate-sugar pyrophosphorylase from Vibrio cholerae RC9. Northeast Structural Genomics Consortium (NESG) Target VcR193. 2012-04-26 2012-05-23 Vorobiev, S.,Neely, H.,Su, M.,Seetharaman, J.,Mao, M.,Xiao, R.,Kohan, E.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the nucleoside-diphosphate-sugar pyrophosphorylase from Vibrio cholerae RC9. To be Published 0 0 0 0 4F2V 24705591 Crystal Structure of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR165 2012-05-08 2012-05-30 Rajagopalan, S.,Wang, C.,Yu, K.,Kuzin, A.P.,Richter, F.,Lew, S.,Miklos, A.E.,Matthews, M.L.,Seetharaman, J.,Su, M.,Hunt, J.F.,Cravatt, B.F.,Baker, D. Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol. 2014 10 386 391 4F12 22660477 Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 2012-05-05 2012-06-06 Geng, Y.,Xiong, D.,Mosyak, L.,Malito, D.L.,Kniazeff, J.,Chen, Y.,Burmakina, S.,Quick, M.,Bush, M.,Javitch, J.A.,Pin, J.P.,Fan, Q.R. Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2. Nat.Neurosci. 2012 15 970 978 4ETJ 24705591 Crystal Structure of E6H variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR185 2012-04-24 2012-06-13 Rajagopalan, S.,Wang, C.,Yu, K.,Kuzin, A.P.,Richter, F.,Lew, S.,Miklos, A.E.,Matthews, M.L.,Seetharaman, J.,Su, M.,Hunt, J.F.,Cravatt, B.F.,Baker, D. Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol. 2014 10 386 391 4ETK 24705591 Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186 2012-04-24 2012-06-13 Rajagopalan, S.,Wang, C.,Yu, K.,Kuzin, A.P.,Richter, F.,Lew, S.,Miklos, A.E.,Matthews, M.L.,Seetharaman, J.,Su, M.,Hunt, J.F.,Cravatt, B.F.,Baker, D. Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat.Chem.Biol. 2014 10 386 391 4F6A High-resolution x-ray Structure of the tetramutant of BH1408 protein from Bacillus halodurans, Northeast Structural Genomics Consortium (NESG) Target BhR182 2012-05-14 2012-06-13 Kuzin, A.,Neely, H.,Odukwe, N.,Seetharaman, J.,Patel, P.,Xiao, R.,Kohan, E.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Northeast Structural Genomics Consortium Target BhR182 To be Published 0 0 0 0 3V72 22651551 Crystal Structure of Rat DNA polymerase beta Mutator E295K: Enzyme-dsDNA 2011-12-20 2012-07-04 Li, Y.,Gridley, C.L.,Jaeger, J.,Sweasy, J.B.,Schlick, T. Unfavorable Electrostatic and Steric Interactions in DNA Polymerase beta E295K Mutant Interfere with the Enzyme s Pathway J.Am.Chem.Soc. 2012 134 9999 10010 4G06 Crystal structure of protein SP_0782 (7-79) from Streptococcus pneumoniae complexed with ssDNA. Northeast Structural Genomics Consortium (NESG) target SPR104 2012-07-09 2012-07-25 Kuzin, A.P.,Su, M.,Seetharaman, J.,Patel, P.,Xiao, R.,Ciccosanti, C.,Lee, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target SpR104 To be Published 0 0 0 0 4FDL 22795132 Crystal structure of Caspase-7 2012-05-28 2012-08-01 Feldman, T.,Kabaleeswaran, V.,Jang, S.B.,Antczak, C.,Djaballah, H.,Wu, H.,Jiang, X. A class of allosteric caspase inhibitors identified by high-throughput screening. Mol.Cell 2012 47 585 595 4FMK 22902367 Crystal structure of mouse nectin-2 extracellular fragment D1-D2 2012-06-17 2012-08-22 Harrison, O.J.,Vendome, J.,Brasch, J.,Jin, X.,Hong, S.,Katsamba, P.S.,Ahlsen, G.,Troyanovsky, R.B.,Troyanovsky, S.M.,Honig, B.,Shapiro, L. Nectin ectodomain structures reveal a canonical adhesive interface. Nat.Struct.Mol.Biol. 2012 19 906 915 4FN0 22902367 Crystal structure of mouse nectin-2 extracellular fragment D1-D2, 2nd crystal form 2012-06-18 2012-08-22 Harrison, O.J.,Vendome, J.,Brasch, J.,Jin, X.,Hong, S.,Katsamba, P.S.,Ahlsen, G.,Troyanovsky, R.B.,Troyanovsky, S.M.,Honig, B.,Shapiro, L. Nectin ectodomain structures reveal a canonical adhesive interface. Nat.Struct.Mol.Biol. 2012 19 906 915 4FOM 22902367 Crystal structure of human nectin-3 full ectodomain (D1-D3) 2012-06-20 2012-08-22 Harrison, O.J.,Vendome, J.,Brasch, J.,Jin, X.,Hong, S.,Katsamba, P.S.,Ahlsen, G.,Troyanovsky, R.B.,Troyanovsky, S.M.,Honig, B.,Shapiro, L. Nectin ectodomain structures reveal a canonical adhesive interface. Nat.Struct.Mol.Biol. 2012 19 906 915 4FQP 22902367 Crystal structure of human Nectin-like 5 full ectodomain (D1-D3) 2012-06-25 2012-08-22 Harrison, O.J.,Vendome, J.,Brasch, J.,Jin, X.,Hong, S.,Katsamba, P.S.,Ahlsen, G.,Troyanovsky, R.B.,Troyanovsky, S.M.,Honig, B.,Shapiro, L. Nectin ectodomain structures reveal a canonical adhesive interface. Nat.Struct.Mol.Biol. 2012 19 906 915 4FS0 22902367 Crystal structure of mutant F136D of mouse nectin-2 extracellular fragment D1-D2 2012-06-26 2012-08-22 Harrison, O.J.,Vendome, J.,Brasch, J.,Jin, X.,Hong, S.,Katsamba, P.S.,Ahlsen, G.,Troyanovsky, R.B.,Troyanovsky, S.M.,Honig, B.,Shapiro, L. Nectin ectodomain structures reveal a canonical adhesive interface. Nat.Struct.Mol.Biol. 2012 19 906 915 4FYG 22872863 Structural basis for substrate recognition by a novel Legionella phosphoinositide phosphatase 2012-07-04 2012-08-22 Hsu, F.,Zhu, W.,Brennan, L.,Tao, L.,Luo, Z.Q.,Mao, Y. Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc.Natl.Acad.Sci.USA 2012 109 13567 13572 4GPM 28338692 Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR264. 2012-08-21 2012-09-05 Fallas, J.A.,Ueda, G.,Sheffler, W.,Nguyen, V.,McNamara, D.E.,Sankaran, B.,Pereira, J.H.,Parmeggiani, F.,Brunette, T.J.,Cascio, D.,Yeates, T.R.,Zwart, P.,Baker, D. Computational design of self-assembling cyclic protein homo-oligomers. NAT.CHEM. 2017 9 353 360 4GVW Three-dimensional structure of the de novo designed serine hydrolase 2bfq_3, Northeast Structural Genomics Consortium (NESG) Target OR248 2012-08-31 2012-09-12 Kuzin, A.,Lew, S.,Seetharaman, J.,Rajagopalan, S.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target OR248 To be Published 0 0 0 0 4HB5 28338692 Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR267. 2012-09-27 2012-10-10 Fallas, J.A.,Ueda, G.,Sheffler, W.,Nguyen, V.,McNamara, D.E.,Sankaran, B.,Pereira, J.H.,Parmeggiani, F.,Brunette, T.J.,Cascio, D.,Yeates, T.R.,Zwart, P.,Baker, D. Computational design of self-assembling cyclic protein homo-oligomers. NAT.CHEM. 2017 9 353 360 4EY8 23035744 Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2 2012-05-01 2012-10-17 Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem. 2012 55 10282 10286 4GXY 23064646 RNA structure 2012-09-04 2012-10-17 Peselis, A.,Serganov, A. Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch. Nat.Struct.Mol.Biol. 2012 19 1182 1184 4HHU Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR280. 2012-10-10 2012-10-24 Vorobiev, S.,Lew, S.,Lin, Y.-R.,Seetharaman, J.,Castelllanos, J.,Maglaqui, M.,Xiao, R.,Lee, D.,Koga, N.,Koga, R.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of Engineered Protein OR280. To be Published 0 0 0 0 4GMV 23483482 Crystal Structure of the coiled-coil, RA and PH domains of Lamellipodin 2012-08-16 2012-11-28 Chang, Y.C.,Zhang, H.,Brennan, M.L.,Wu, J. Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein Cell 2013 4 211 219 4G3T 23184707 Mycobacterium smegmatis DprE1 - hexagonal crystal form 2012-07-15 2012-12-05 Li, H.,Jogl, G. Crystal structure of decaprenylphosphoryl-beta- D-ribose 2'-epimerase from Mycobacterium smegmatis. Proteins 2013 81 538 543 4GIF 23212381 C-terminal coiled-coil domain of transient receptor potential channel TRPP3 (PKD2L1, Polycystin-L) 2012-08-08 2012-12-05 Yu, Y.,Ulbrich, M.H.,Li, M.H.,Dobbins, S.,Zhang, W.K.,Tong, L.,Isacoff, E.Y.,Yang, J. Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun 2012 3 1252 1252 3V7J Co-crystal structure of Wild Type Rat polymerase beta: Enzyme-DNA binary complex 2011-12-21 2013-01-16 Rangarajan, S.,Gridley, C.L.,Firbank, S.,Dalal, S.,Sweasy, J.B.,Jaeger, J. Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain To be Published 0 0 0 0 3V7L Apo Structure of Rat DNA polymerase beta K72E variant 2011-12-21 2013-01-16 Rangarajan, S.,Gridley, C.L.,Firbank, S.,Dalal, S.,Sweasy, J.B.,Jaeger, J. Crystallographic studies of K72E mutant DNA polymerase explain loss of lyase function and reveal changes in the overall conformational state of the polymerase domain To be Published 0 0 0 0 4FCZ Crystal Structure of Toluene-tolerance protein from Pseudomonas putida (strain KT2440), Northeast Structural Genomics Consortium (NESG) Target PpR99 2012-05-25 2013-02-13 Kuzin, A.,Su, M.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Ciccosanti, C.,Wang, H.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target PpR99 To be Published 0 0 0 0 4FDB Three-dimensional structure of the protein prib from ralstonia solanacearum at the resolution 1.8a. northeast structural genomics consortium target rsr213c 2012-05-27 2013-02-13 Kuzin, A.,Neely, H.,Seetharaman, J.,Wang, H.,Sahdev, S.,Foote, E.L.,Xiao, R.,Liu, J.,Everett, J.K.,Acton, T.B.,Rost, B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Three-dimensional structure of the protein prib from ralstonia solanacearum at the resolution 1.8a. northeast structural genomics consortium target rsr213c To be Published 0 0 0 0 4JBC Crystal Structure of the computationally designed serine hydrolase 3mmj_2, Northeast Structural Genomics Consortium (NESG) Target OR318 2013-02-19 2013-03-20 Kuzin, A.,Lew, S.,Rajagopalan, S.,Seetharaman, J.,Maglaqui, M.,Xiao, R.,Lee, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Baker, D.,Hunt, J.F. Crystal Structure of the computationally designed serine hydrolase 3mmj_2, Northeast Structural Genomics Consortium (NESG) Target OR318 To be Published 0 0 0 0 4J9T 23924187 Crystal structure of a putative, de novo designed unnatural amino acid dependent metalloprotein, northeast structural genomics consortium target OR61 2013-02-17 2013-03-27 Mills, J.H.,Khare, S.D.,Bolduc, J.M.,Forouhar, F.,Mulligan, V.K.,Lew, S.,Seetharaman, J.,Tong, L.,Stoddard, B.L.,Baker, D. Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy. J.Am.Chem.Soc. 2013 135 13393 13399 4JC0 23542644 Crystal structure of Thermotoga maritima holo RimO in complex with pentasulfide, Northeast Structural Genomics Consortium Target VR77 2013-02-20 2013-04-10 Forouhar, F.,Arragain, S.,Atta, M.,Gambarelli, S.,Mouesca, J.M.,Hussain, M.,Xiao, R.,Kieffer-Jaquinod, S.,Seetharaman, J.,Acton, T.B.,Montelione, G.T.,Mulliez, E.,Hunt, J.F.,Fontecave, M. Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases. Nat.Chem.Biol. 2013 9 333 338 4I53 23667716 Crystal structure of clade C1086 HIV-1 gp120 core in complex with DMJ-II-121 2012-11-28 2013-05-29 Lalonde, J.M.,Le-Khac, M.,Jones, D.M.,Courter, J.R.,Park, J.,Schon, A.,Princiotto, A.M.,Wu, X.,Mascola, J.R.,Freire, E.,Sodroski, J.,Madani, N.,Hendrickson, W.A.,Smith, A.B. Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett 2013 4 338 343 4JNE 23708608 Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP 2013-03-15 2013-05-29 Qi, R.,Sarbeng, E.B.,Liu, Q.,Le, K.Q.,Xu, X.,Xu, H.,Yang, J.,Wong, J.L.,Vorvis, C.,Hendrickson, W.A.,Zhou, L.,Liu, Q. Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat.Struct.Mol.Biol. 2013 20 900 907 4JNF 23708608 Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP 2013-03-15 2013-05-29 Qi, R.,Sarbeng, E.B.,Liu, Q.,Le, K.Q.,Xu, X.,Xu, H.,Yang, J.,Wong, J.L.,Vorvis, C.,Hendrickson, W.A.,Zhou, L.,Liu, Q. Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat.Struct.Mol.Biol. 2013 20 900 907 4KS9 23791943 Crystal Structure of Malonyl-CoA decarboxylase (Rmet_2797) from Cupriavidus metallidurans, Northeast Structural Genomics Consortium Target CrR76 2013-05-17 2013-06-19 Froese, D.S.,Forouhar, F.,Tran, T.H.,Vollmar, M.,Kim, Y.S.,Lew, S.,Neely, H.,Seetharaman, J.,Shen, Y.,Xiao, R.,Acton, T.B.,Everett, J.K.,Cannone, G.,Puranik, S.,Savitsky, P.,Krojer, T.,Pilka, E.S.,Kiyani, W.,Lee, W.H.,Marsden, B.D.,von Delft, F.,Allerston, C.K.,Spagnolo, L.,Gileadi, O.,Montelione, G.T.,Oppermann, U.,Yue, W.W.,Tong, L. Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 2013 21 1182 1192 4KSA 23791943 Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127 2013-05-17 2013-06-19 Froese, D.S.,Forouhar, F.,Tran, T.H.,Vollmar, M.,Kim, Y.S.,Lew, S.,Neely, H.,Seetharaman, J.,Shen, Y.,Xiao, R.,Acton, T.B.,Everett, J.K.,Cannone, G.,Puranik, S.,Savitsky, P.,Krojer, T.,Pilka, E.S.,Kiyani, W.,Lee, W.H.,Marsden, B.D.,von Delft, F.,Allerston, C.K.,Spagnolo, L.,Gileadi, O.,Montelione, G.T.,Oppermann, U.,Yue, W.W.,Tong, L. Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 2013 21 1182 1192 4KSF 23791943 Crystal Structure of Malonyl-CoA decarboxylase from Agrobacterium vitis, Northeast Structural Genomics Consortium Target RiR35 2013-05-17 2013-06-19 Froese, D.S.,Forouhar, F.,Tran, T.H.,Vollmar, M.,Kim, Y.S.,Lew, S.,Neely, H.,Seetharaman, J.,Shen, Y.,Xiao, R.,Acton, T.B.,Everett, J.K.,Cannone, G.,Puranik, S.,Savitsky, P.,Krojer, T.,Pilka, E.S.,Kiyani, W.,Lee, W.H.,Marsden, B.D.,von Delft, F.,Allerston, C.K.,Spagnolo, L.,Gileadi, O.,Montelione, G.T.,Oppermann, U.,Yue, W.W.,Tong, L. Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure 2013 21 1182 1192 4KYB Crystal Structure of de novo designed serine hydrolase OSH55.14_E3, Northeast Structural Genomics Consortium Target OR342 2013-05-28 2013-06-19 Kuzin, A.,Lew, S.,Rajagopalan, S.,Seetharaman, J.,Mao, L.,Xiao, R.,Lee, D.,Raja, S.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Tong, L.,Hunt, J.F. Northeast Structural Genomics Consortium Target OR342 To be Published 0 0 0 0 4L1J Three dimensional structure of mutant D143A of human HD domain-containing protein 2, Northeast Structural Genomics Consortium (NESG) Target HR6723 2013-06-03 2013-06-19 Kuzin, A.,Su, M.,Yakunin, A.,Beloglazova, O.,Seetharaman, J.,Maglaqui, M.,Xiao, R.,Lee, D.,Brown, G.,Flick, R.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Three dimensional structure of mutant D143A of human HD domain-containing protein 2, Northeast Structural Genomics Consortium (NESG) Target HR6723 To be Published 0 0 0 0 4L6E Crystal Structure of the RanBD1 fourth domain of E3 SUMO-protein ligase RanBP2. Northeast Structural Genomics Consortium (NESG) Target HR9193b 2013-06-12 2013-06-26 Vorobiev, S.,Su, M.,Seetharaman, J.,Mao, L.,Xiao, R.,Maglaqui, M.,Kogan, S.,Wang, H.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Hunt, J.F.,Tong, L. Crystal Structure of the RanBD1 fourth domain of E3 SUMO-protein ligase RanBP2. To be Published 0 0 0 0 4GZK 23568335 Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 2012-09-06 2013-07-24 Ren, Z.,C Franklin, M.,Ghose, R. Structure of the RNA-directed RNA Polymerase from the cystovirus 12. Proteins 2013 81 1479 1484 4IEG 23568335 Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form) 2012-12-13 2013-07-24 Ren, Z.,C Franklin, M.,Ghose, R. Structure of the RNA-directed RNA Polymerase from the cystovirus 12. Proteins 2013 81 1479 1484 4KPA 23829560 Crystal structure of cytochrome P450 BM-3 in complex with N-palmitoylglycine (NPG) 2013-05-13 2013-07-24 Catalano, J.,Sadre-Bazzaz, K.,Amodeo, G.A.,Tong, L.,McDermott, A. Structural Evidence: A Single Charged Residue Affects Substrate Binding in Cytochrome P450 BM-3. Biochemistry 2013 52 6807 6815 4KYZ 26650357 Three-dimensional structure of triclinic form of de novo design insertion domain, Northeast Structural Genomics Consortium (NESG) Target OR327 2013-05-29 2013-07-24 King, I.C.,Gleixner, J.,Doyle, L.,Kuzin, A.,Hunt, J.F.,Xiao, R.,Montelione, G.T.,Stoddard, B.L.,DiMaio, F.,Baker, D. Precise assembly of complex beta sheet topologies from de novo designed building blocks. Elife 2015 4 0 0 4J96 23871672 Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer. 2013-02-15 2013-08-07 Chen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M. Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep 2013 4 376 384 4IBM 23935097 Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1 2012-12-08 2013-08-21 Anastassiadis, T.,Duong-Ly, K.C.,Deacon, S.W.,Lafontant, A.,Ma, H.,Devarajan, K.,Dunbrack, R.L.,Wu, J.,Peterson, J.R. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. J.Biol.Chem. 2013 288 28068 28077 4K33 23972473 Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma 2013-04-10 2013-09-11 Huang, Z.,Chen, H.,Blais, S.,Neubert, T.A.,Li, X.,Mohammadi, M. Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation. Structure 2013 21 1889 1896 4HLR Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein 2012-10-17 2013-10-30 Liu, J.,Li, Q.,Dey, A.K.,Moore, J.P.,Lu, M. Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein To be Published 0 0 0 0 4N6C Crystal Structure of the B1RZQ2 protein from Streptococcus pneumoniae. Northeast Structural Genomics Consortium (NESG) Target SpR36. 2013-10-11 2013-10-30 Vorobiev, S.,Seetharaman, J.,Patel, D.,Xiao, R.,Ciccosanti, C.,Wang, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the B1RZQ2 protein from Streptococcus pneumoniae. To be Published 0 0 0 0 4NAR Crystal Structure of the Q9WYS3 protein from Thermotoga maritima. Northeast Structural Genomics Consortium Target VR152 2013-10-22 2013-11-06 Vorobiev, S.,Lew, S.,Seetharaman, J.,Chi, Y.,Xiao, R.,Maglaqui, M.,Lee, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the Q9WYS3 protein from Thermotoga maritima. To be Published 0 0 0 0 4NE7 Crystal Structure of engineered Kumamolisin-As from Alicyclobacillus sendaiensis, Northeast Structural Genomics Consortium (NESG) Target OR367 2013-10-28 2013-11-20 Guan, R.,Pultz, I.S.,Seetharaman, J.,Kornhaber, G.,Mao, L.,Xiao, R.,Maglaqui, M.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T. Northeast Structural Genomics Consortium Target OR367 To be Published 0 0 0 0 4NEY Crystal Structure of an engineered protein with ferredoxin fold, Northeast Structural Genomics Consortium (NESG) Target OR277 2013-10-30 2014-01-15 Guan, R.,Lin, Y.-R.,Koga, N.,Koga, R.,Castellanos, J.,Seetharaman, J.,Maglaqui, M.,Sahdev, S.,Mao, L.,Xiao, R.,Everett, J.K.,Baker, D.,Montelione, G.T. Northeast Structural Genomics Consortium Target OR277 To be published 0 0 0 0 4NEZ Crystal Structure of an engineered protein with ferredoxin fold, Northeast Structural Genomics Consortium (NESG) Target OR276 2013-10-30 2014-01-15 Guan, R.,Lin, Y.-R.,Koga, N.,Koga, R.,Castellanos, J.,Seetharaman, J.,Maglaqui, M.,Sahdev, S.,Mao, L.,Xiao, R.,Everett, J.K.,Baker, D.,Montelione, G.T.,Northeast Structural Genomics Consortium (NESG) Northeast Structural Genomics Consortium Target OR276 To be published 0 0 0 0 4LW5 24408076 Crystal structure of all-trans green fluorescent protein 2013-07-26 2014-02-05 Rosenman, D.J.,Huang, Y.M.,Xia, K.,Fraser, K.,Jones, V.E.,Lamberson, C.M.,Van Roey, P.,Colon, W.,Bystroff, C. Green-lighting green fluorescent protein: Faster and more efficient folding by eliminating a cis-trans peptide isomerization event. Protein Sci. 2014 23 400 410 4PQ8 Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR465 2014-02-28 2014-03-12 Vorobiev, S.,Parmeggiani, F.,Seetharaman, J.,Janjua, H.,Xiao, R.,Maglaqui, M.,Park, K.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Tong, L.,Hunt, J. Crystal Structure of Engineered Protein OR465. To be Published 0 0 0 0 4HOG 24568657 Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H) 2012-10-22 2014-03-19 G-Dayanandan, N.,Paulsen, J.L.,Viswanathan, K.,Keshipeddy, S.,Lombardo, M.N.,Zhou, W.,Lamb, K.M.,Sochia, A.E.,Alverson, J.B.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J.Med.Chem. 2014 57 2643 2656 4PWW Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR494. 2014-03-21 2014-04-09 Vorobiev, S.,Lin, Y.-R.,Seetharaman, J.,Xiao, R.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of Engineered Protein OR494. To be Published 0 0 0 0 4CS5 24728082 Crystal Structure of PCNA from Litopenaeus vannamei 2014-03-04 2014-04-23 Carrasco-Miranda, J.S.,Lopez-Zavala, A.A.,Arvizu-Flores, A.A.,Garcia-Orozco, K.D.,Stojanoff, V.,Rudino-Pinera, E.,Brieba, L.G.,Sotelo-Mundo, R.R. Crystal Structure of the Shrimp Proliferating Cell Nuclear Antigen: Structural Complementarity with Wssv DNA Polymerase Pip-Box. Plos One 2014 9 94369 0 4O1W 24727932 Crystal Structure of Colwellia psychrerythraea cytochrome c 2013-12-16 2014-04-23 Harvilla, P.B.,Wolcott, H.N.,Magyar, J.S. The structure of ferricytochrome c552 from the psychrophilic marine bacterium Colwellia psychrerythraea 34H. Metallomics 2014 6 1126 1130 4PGR 24904158 Crystal structure of YetJ from Bacillus Subtilis at pH 8 2014-05-02 2014-06-04 Chang, Y.,Bruni, R.,Kloss, B.,Assur, Z.,Kloppmann, E.,Rost, B.,Hendrickson, W.A.,Liu, Q. Structural basis for a pH-sensitive calcium leak across membranes. Science 2014 344 1131 1135 4PGS 24904158 Crystal structure of YetJ from Bacillus Subtilis at pH 6 by soaking 2014-05-02 2014-06-04 Chang, Y.,Bruni, R.,Kloss, B.,Assur, Z.,Kloppmann, E.,Rost, B.,Hendrickson, W.A.,Liu, Q. Structural basis for a pH-sensitive calcium leak across membranes. Science 2014 344 1131 1135 4PGU 24904158 Crystal structure of YetJ from Bacillus Subtilis at pH 7 by soaking 2014-05-02 2014-06-04 Chang, Y.,Bruni, R.,Kloss, B.,Assur, Z.,Kloppmann, E.,Rost, B.,Hendrickson, W.A.,Liu, Q. Structural basis for a pH-sensitive calcium leak across membranes. Science 2014 344 1131 1135 4PGV 24904158 Crystal structure of YetJ from Bacillus Subtilis at pH 8 by back soaking 2014-05-02 2014-06-04 Chang, Y.,Bruni, R.,Kloss, B.,Assur, Z.,Kloppmann, E.,Rost, B.,Hendrickson, W.A.,Liu, Q. Structural basis for a pH-sensitive calcium leak across membranes. Science 2014 344 1131 1135 4Q28 Crystal Structure of the Plectin 1 and 2 Repeats of the Human Periplakin. Northeast Structural Genomics Consortium (NESG) Target HR9083A 2014-04-07 2014-06-18 Vorobiev, S.,Lew, S.,Seetharaman, J.,Janjua, H.,Xiao, R.,O'Connell, P.T.,Maglaqui, M.,Wang, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the Plectin 1 and 2 Repeats of Human Periplakin. To be Published 0 0 0 0 4NQQ 25253890 Crystal structure of mouse P-cadherin extracellular domains EC1-EC2 2013-11-25 2014-09-24 Vendome, J.,Felsovalyi, K.,Song, H.,Yang, Z.,Jin, X.,Brasch, J.,Harrison, O.J.,Ahlsen, G.,Bahna, F.,Kaczynska, A.,Katsamba, P.S.,Edmond, D.,Hubbell, W.L.,Shapiro, L.,Honig, B. Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4NUM 25253890 Crystal structure of mouse N-cadherin EC1-2 A78SI92M 2013-12-03 2014-09-24 Vendome, J.,Felsovalyi, K.,Song, H.,Yang, Z.,Jin, X.,Brasch, J.,Harrison, O.J.,Ahlsen, G.,Bahna, F.,Kaczynska, A.,Katsamba, P.S.,Edmond, D.,Hubbell, W.L.,Shapiro, L.,Honig, B. Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4NUP 25253890 Crystal structure of mouse N-cadherin EC1-2 with AA insertion between residues 2 and 3 2013-12-03 2014-09-24 Vendome, J.,Felsovalyi, K.,Song, H.,Yang, Z.,Jin, X.,Brasch, J.,Harrison, O.J.,Ahlsen, G.,Bahna, F.,Kaczynska, A.,Katsamba, P.S.,Edmond, D.,Hubbell, W.L.,Shapiro, L.,Honig, B. Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4NUQ 25253890 Crystal structure of mouse N-cadherin EC1-2 W2F 2013-12-03 2014-09-24 Vendome, J.,Felsovalyi, K.,Song, H.,Yang, Z.,Jin, X.,Brasch, J.,Harrison, O.J.,Ahlsen, G.,Bahna, F.,Kaczynska, A.,Katsamba, P.S.,Edmond, D.,Hubbell, W.L.,Shapiro, L.,Honig, B. Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4R80 Crystal Structure of a De Novo Designed Beta Sheet Protein, Cystatin Fold, Northeast Structural Genomics Consortium (NESG) Target OR486 2014-08-29 2014-09-24 Guan, R.,Marcos, E.,O'Connell, P.,Seetharaman, J.,Janjua, H.,Xiao, R.,Maglaqui, M.,Acton, T.B.,Everett, J.K.,Baker, D.,Montelione, G.T.,Northeast Structural Genomics Consortium (NESG) Crystal Structure of an engineered protein with denovo beta sheet design, Northeast Structural Genomics Consortium (NESG) Target OR486 To be Published 0 0 0 0 4RJV Crystal Structure of a De Novo Designed Ferredoxin Fold, Northeast Structural Genomics Consortium (NESG) Target OR461 2014-10-09 2014-10-22 O'Connell, P.T.,Lin, Y.-R.,Guan, R.,Koga, N.,Koga, R.,Seetharaman, J.,Janjua, H.,Xiao, R.,Maglaqui, M.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Northeast Structural Genomics Consortium (NESG) Northeast Structural Genomics Consortium Target OR461 To be published 0 0 0 0 4QQ5 25317566 Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations 2014-06-26 2014-10-29 Huang, Z.,Tan, L.,Wang, H.,Liu, Y.,Blais, S.,Deng, J.,Neubert, T.A.,Gray, N.S.,Li, X.,Mohammadi, M. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol. 2015 10 299 309 4QQC 25349422 Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations 2014-06-27 2014-10-29 Tan, L.,Wang, J.,Tanizaki, J.,Huang, Z.,Aref, A.R.,Rusan, M.,Zhu, S.J.,Zhang, Y.,Ercan, D.,Liao, R.G.,Capelletti, M.,Zhou, W.,Hur, W.,Kim, N.,Sim, T.,Gaudet, S.,Barbie, D.A.,Yeh, J.R.,Yun, C.H.,Hammerman, P.S.,Mohammadi, M.,Janne, P.A.,Gray, N.S. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4QQJ 25317566 Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain Harboring the V550L Gate-Keeper Mutation 2014-06-27 2014-10-29 Huang, Z.,Tan, L.,Wang, H.,Liu, Y.,Blais, S.,Deng, J.,Neubert, T.A.,Gray, N.S.,Li, X.,Mohammadi, M. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol. 2015 10 299 309 4QQT 25317566 Crystal Structure of FGF Receptor (FGFR) 4 Tyrosine Kinase Domain 2014-06-29 2014-10-29 Huang, Z.,Tan, L.,Wang, H.,Liu, Y.,Blais, S.,Deng, J.,Neubert, T.A.,Gray, N.S.,Li, X.,Mohammadi, M. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol. 2015 10 299 309 4QRC 25317566 Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib 2014-06-30 2014-10-29 Huang, Z.,Tan, L.,Wang, H.,Liu, Y.,Blais, S.,Deng, J.,Neubert, T.A.,Gray, N.S.,Li, X.,Mohammadi, M. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol. 2015 10 299 309 4R6V 25349422 Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations 2014-08-26 2014-10-29 Tan, L.,Wang, J.,Tanizaki, J.,Huang, Z.,Aref, A.R.,Rusan, M.,Zhu, S.J.,Zhang, Y.,Ercan, D.,Liao, R.G.,Capelletti, M.,Zhou, W.,Hur, W.,Kim, N.,Sim, T.,Gaudet, S.,Barbie, D.A.,Yeh, J.R.,Yun, C.H.,Hammerman, P.S.,Mohammadi, M.,Janne, P.A.,Gray, N.S. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4RL6 Crystal Structure of the Q04L03_STRP2 protein from Streptococcus pneumoniae. Northeast Structural Genomics Consortium Target SpR105 2014-10-15 2014-11-05 Vorobiev, S.,Neely, H.M.,Odukwe, C.D.,Seetharaman, J.,Mao, L.,Xiao, R.,Kohan, E.,Wang, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of the Q04L03_STRP2 protein from Streptococcus pneumoniae. To be Published 0 0 0 0 4RV1 Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium (NESG) Target OR497. 2014-11-24 2014-12-10 Vorobiev, S.,Parmeggiani, F.,Seetharaman, J.,Xiao, R.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of Engineered Protein OR497. To be Published 0 0 0 0 4RZP Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium (NESG) Target OR366. 2014-12-23 2015-01-07 Vorobiev, S.,Parmeggiani, F.,Dimaio, F.,Seetharaman, J.,Sahdev, S.,Xiao, R.,Kogan, S.,Everett, J.K.,Acton, T.B.,Baker, D.,Montelione, G.T.,Tong, L.,Hunt, J.F. Crystal Structure of Engineered Protein OR366 To be Published 0 0 0 0 4RGM 25572397 Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 20B1 2014-09-30 2015-01-21 Dutta, K.,Varshney, A.K.,Franklin, M.C.,Goger, M.,Wang, X.,Fries, B.C. Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies. J.Biol.Chem. 2015 290 6715 6730 4RGO 25572397 Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 14G8 2014-09-30 2015-01-21 Dutta, K.,Varshney, A.K.,Franklin, M.C.,Goger, M.,Wang, X.,Fries, B.C. Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies. J.Biol.Chem. 2015 290 6715 6730 4WB5 25605907 Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit) 2014-09-02 2015-01-21 Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Robine, N.,Darnell, R.B.,Hendrickson, W.A. Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA 2015 112 1374 1379 4WB6 25605907 Crystal structure of a L205R mutant of human cAMP-dependent protein kinase A (catalytic alpha subunit) 2014-09-02 2015-01-21 Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Robine, N.,Darnell, R.B.,Hendrickson, W.A. Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA 2015 112 1374 1379 4WB7 25605907 Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A (catalytic alpha subunit) 2014-09-02 2015-01-21 Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Robine, N.,Darnell, R.B.,Hendrickson, W.A. Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA 2015 112 1374 1379 4WB8 25605907 Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit), exon 1 deletion 2014-09-02 2015-01-21 Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Robine, N.,Darnell, R.B.,Hendrickson, W.A. Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA 2015 112 1374 1379 4RYI 25635100 Crystal structure of BcTSPO/PK11195 complex 2014-12-15 2015-01-28 Guo, Y.,Kalathur, R.C.,Liu, Q.,Kloss, B.,Bruni, R.,Ginter, C.,Kloppmann, E.,Rost, B.,Hendrickson, W.A. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science 2015 347 551 555 4RYQ 25635100 Crystal structure of BcTSPO, type 2 at 1.7 Angstrom 2014-12-16 2015-01-28 Guo, Y.,Kalathur, R.C.,Liu, Q.,Kloss, B.,Bruni, R.,Ginter, C.,Kloppmann, E.,Rost, B.,Hendrickson, W.A. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science 2015 347 551 555 4RYR 25635100 Crystal structure of BcTSPO, type 2 at 1.7 Angstrom with DMSO 2014-12-16 2015-01-28 Guo, Y.,Kalathur, R.C.,Liu, Q.,Kloss, B.,Bruni, R.,Ginter, C.,Kloppmann, E.,Rost, B.,Hendrickson, W.A. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science 2015 347 551 555 4RYJ 25635100 Crystal structure of apo dimer of BcTSPO 2014-12-15 2015-02-11 Guo, Y.,Kalathur, R.C.,Liu, Q.,Kloss, B.,Bruni, R.,Ginter, C.,Kloppmann, E.,Rost, B.,Hendrickson, W.A. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science 2015 347 551 555 4RYN 25635100 Crystal structure of BcTSPO, type1 monomer 2014-12-15 2015-02-11 Guo, Y.,Kalathur, R.C.,Liu, Q.,Kloss, B.,Bruni, R.,Ginter, C.,Kloppmann, E.,Rost, B.,Hendrickson, W.A. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science 2015 347 551 555 4RYO 25635100 Crystal structure of BcTSPO type II high resolution monomer 2014-12-15 2015-04-22 Guo, Y.,Kalathur, R.C.,Liu, Q.,Kloss, B.,Bruni, R.,Ginter, C.,Kloppmann, E.,Rost, B.,Hendrickson, W.A. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science 2015 347 551 555 4XYK 25985179 Crystal structure of human phosphofructokinase-1 in complex with ADP, Northeast Structural Genomics Consortium Target HR9275 2015-02-02 2015-05-06 Webb, B.A.,Forouhar, F.,Szu, F.E.,Seetharaman, J.,Tong, L.,Barber, D.L. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature 2015 523 111 114 4XYJ 25985179 Crystal structure of human phosphofructokinase-1 in complex with ATP and Mg, Northeast Structural Genomics Consortium Target HR9275 2015-02-02 2015-05-20 Webb, B.A.,Forouhar, F.,Szu, F.E.,Seetharaman, J.,Tong, L.,Barber, D.L. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature 2015 523 111 114 4RMK 26235031 Crystal structure of the Olfactomedin domain of latrophilin 3 in P65 crystal form 2014-10-21 2015-08-19 Ranaivoson, F.M.,Liu, Q.,Martini, F.,Bergami, F.,von Daake, S.,Li, S.,Lee, D.,Demeler, B.,Hendrickson, W.A.,Comoletti, D. Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development. Structure 2015 23 1665 1677 4ZPM 26478182 Crystal Structure of Protocadherin Alpha C2 EC1-3 2015-05-08 2015-10-28 Rubinstein, R.,Thu, C.A.,Goodman, K.M.,Wolcott, H.N.,Bahna, F.,Mannepalli, S.,Ahlsen, G.,Chevee, M.,Halim, A.,Clausen, H.,Maniatis, T.,Shapiro, L.,Honig, B. Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions. Cell 2015 163 629 642 4X3M Crystal Structure of TTHA0275 from Thermus thermophilus (HB8) in complex with Adenosine in space group P212121 2014-12-01 2015-11-11 Demirci, H.,Belardinelli, R.,Jogl, G. Crystal Structure of TTHA0275 from Thermus thermophilus (HB8) To Be Published 0 0 0 0 4R9W 26391892 Crystal structure of platelet factor 4 complexed with fondaparinux 2014-09-08 2015-12-16 Cai, Z.,Yarovoi, S.V.,Zhu, Z.,Rauova, L.,Hayes, V.,Lebedeva, T.,Liu, Q.,Poncz, M.,Arepally, G.,Cines, D.B.,Greene, M.I. Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nat Commun 2015 6 8277 8277 4R9Y 26391892 Crystal structure of KKOFab in complex with platelet factor 4 2014-09-08 2015-12-16 Cai, Z.,Yarovoi, S.V.,Zhu, Z.,Rauova, L.,Hayes, V.,Lebedeva, T.,Liu, Q.,Poncz, M.,Arepally, G.,Cines, D.B.,Greene, M.I. Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nat Commun 2015 6 8277 8277 5FLW 27050262 Crystal structure of putative exo-beta-1,3-galactanase from Bifidobacterium bifidum s17 2015-10-28 2015-12-23 Godoy, A.S.,de Lima, M.Z.,Camilo, C.M.,Polikarpov, I. Crystal structure of a putative exo-beta-1,3-galactanase from Bifidobacterium bifidum S17. Acta Crystallogr F Struct Biol 2016 72 288 293 5E85 26655470 isolated SBD of BiP 2015-10-13 2015-12-30 Yang, J.,Nune, M.,Zong, Y.,Zhou, L.,Liu, Q. Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP. Structure 2015 23 2191 2203 5E86 26655470 isolated SBD of BiP with loop34 modification 2015-10-13 2015-12-30 Yang, J.,Nune, M.,Zong, Y.,Zhou, L.,Liu, Q. Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP. Structure 2015 23 2191 2203 5EKE 26729507 Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB (F215A mutant) 2015-11-03 2016-01-06 Ardiccioni, C.,Clarke, O.B.,Tomasek, D.,Issa, H.A.,von Alpen, D.C.,Pond, H.L.,Banerjee, S.,Rajashankar, K.R.,Liu, Q.,Guan, Z.,Li, C.,Kloss, B.,Bruni, R.,Kloppmann, E.,Rost, B.,Manzini, M.C.,Shapiro, L.,Mancia, F. Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. Nat Commun 2016 7 10175 10175 5EKP 26729507 Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB (WT) 2015-11-03 2016-01-06 Ardiccioni, C.,Clarke, O.B.,Tomasek, D.,Issa, H.A.,von Alpen, D.C.,Pond, H.L.,Banerjee, S.,Rajashankar, K.R.,Liu, Q.,Guan, Z.,Li, C.,Kloss, B.,Bruni, R.,Kloppmann, E.,Rost, B.,Manzini, M.C.,Shapiro, L.,Mancia, F. Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis. Nat Commun 2016 7 10175 10175 5C7Q 26524597 Crystal Structure of the Bdellovibrio bacteriovorus Nucleoside Diphosphate Sugar Hydrolase 2015-06-24 2016-01-20 de la Pena, A.H.,Suarez, A.,Duong-Ly, K.C.,Schoeffield, A.J.,Pizarro-Dupuy, M.A.,Zarr, M.,Pineiro, S.A.,Amzel, L.M.,Gabelli, S.B. Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus. Plos One 2015 10 0 0 5E84 26655470 ATP-bound state of BiP 2015-10-13 2016-01-27 Yang, J.,Nune, M.,Zong, Y.,Zhou, L.,Liu, Q. Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP. Structure 2015 23 2191 2203 5EG3 26687682 Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma) 2015-10-26 2016-02-03 Huang, Z.,Marsiglia, W.M.,Basu Roy, U.,Rahimi, N.,Ilghari, D.,Wang, H.,Chen, H.,Gai, W.,Blais, S.,Neubert, T.A.,Mansukhani, A.,Traaseth, N.J.,Li, X.,Mohammadi, M. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma. Mol.Cell 2016 61 98 110 5K6V 27644106 Sidekick-1 immunoglobulin domains 1-4, crystal form 2 2016-05-25 2016-09-28 Goodman, K.M.,Yamagata, M.,Jin, X.,Mannepalli, S.,Katsamba, P.S.,Ahlsen, G.,Sergeeva, A.P.,Honig, B.,Sanes, J.R.,Shapiro, L. Molecular basis of sidekick-mediated cell-cell adhesion and specificity. Elife 2016 5 0 0 5K6W 27644106 Sidekick-1 immunoglobulin domains 1-5 2016-05-25 2016-09-28 Goodman, K.M.,Yamagata, M.,Jin, X.,Mannepalli, S.,Katsamba, P.S.,Ahlsen, G.,Sergeeva, A.P.,Honig, B.,Sanes, J.R.,Shapiro, L. Molecular basis of sidekick-mediated cell-cell adhesion and specificity. Elife 2016 5 0 0 5K6X 27644106 Sidekick-2 immunoglobulin domains 1-4, crystal form 1 2016-05-25 2016-09-28 Goodman, K.M.,Yamagata, M.,Jin, X.,Mannepalli, S.,Katsamba, P.S.,Ahlsen, G.,Sergeeva, A.P.,Honig, B.,Sanes, J.R.,Shapiro, L. Molecular basis of sidekick-mediated cell-cell adhesion and specificity. Elife 2016 5 0 0 5TI9 27762317 Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161 2016-10-01 2016-10-26 Lewis-Ballester, A.,Forouhar, F.,Kim, S.M.,Lew, S.,Wang, Y.,Karkashon, S.,Seetharaman, J.,Batabyal, D.,Chiang, B.Y.,Hussain, M.,Correia, M.A.,Yeh, S.R.,Tong, L. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep 2016 6 35169 35169 5TIA 27762317 Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161 2016-10-01 2016-10-26 Lewis-Ballester, A.,Forouhar, F.,Kim, S.M.,Lew, S.,Wang, Y.,Karkashon, S.,Seetharaman, J.,Batabyal, D.,Chiang, B.Y.,Hussain, M.,Correia, M.A.,Yeh, S.R.,Tong, L. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep 2016 6 35169 35169 5UGX 28166054 Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation 2017-01-10 2017-02-22 Chen, H.,Marsiglia, W.M.,Cho, M.K.,Huang, Z.,Deng, J.,Blais, S.P.,Gai, W.,Bhattacharya, S.,Neubert, T.A.,Traaseth, N.J.,Mohammadi, M. Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Elife 2017 6 0 0 5UHN 28166054 Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation 2017-01-11 2017-02-22 Chen, H.,Marsiglia, W.M.,Cho, M.K.,Huang, Z.,Deng, J.,Blais, S.P.,Gai, W.,Bhattacharya, S.,Neubert, T.A.,Traaseth, N.J.,Mohammadi, M. Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Elife 2017 6 0 0 5K84 Crystal structure of laccase from Thermus thermophilus HB27 (sodium nitrate 10 min) 2016-05-27 2017-06-07 Diaz-Vilchis, A.,Ruiz-Arellano, R.R.,Rosas-Benitez, E.,Stojanoff, V.,Rudino-Pinera, E. Preserving metallic sites affected by radiation damage: the CuT2 case in Thermus thermophilus multicopper oxidase To be Published 0 0 0 0 5V3S 28596570 Crystal structure of IP-1A from Alcaligenes faecalis at 1.8A resolution 2017-03-08 2017-06-14 Yalpani, N.,Altier, D.,Barry, J.,Kassa, A.,Nowatzki, T.M.,Sethi, A.,Zhao, J.Z.,Diehn, S.,Crane, V.,Sandahl, G.,Guan, R.,Poland, B.,Perez Ortega, C.,Nelson, M.E.,Xie, W.,Liu, L.,Wu, G. An Alcaligenes strain emulates Bacillus thuringiensis producing a binary protein that kills corn rootworm through a mechanism similar to Cry34Ab1/Cry35Ab1. Sci Rep 2017 7 3063 3063 5KJO X-ray structure of PcCel45A expressed in Aspergillus nidullans 2016-06-20 2017-06-21 Godoy, A.S.,Ramia, M.P.,Camilo, C.M.,Polikarpov, I. X-ray structure of PcCel45A expressed in Aspergillus nidullans To Be Published 0 0 0 0 5JN0 CRK-II SH2 domain 2016-04-29 2017-08-09 Cho, J.-H. CRK-II SH2 domain To Be Published 0 0 0 0 5W59 28757146 Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c 2017-06-14 2017-08-16 Liu, Y.,Ma, J.,Beenken, A.,Srinivasan, L.,Eliseenkova, A.V.,Mohammadi, M. Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization. Structure 2017 25 1325 0 6ASY 29084938 BiP-ATP2 2017-08-26 2017-12-06 Yang, J.,Zong, Y.,Su, J.,Li, H.,Zhu, H.,Columbus, L.,Zhou, L.,Liu, Q. Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun 2017 8 1201 1201 5W5A 29165665 Crystal structure of Mycobacterium tuberculosis CRP-FNR family transcription factor Cmr (Rv1675c) 2017-06-14 2017-12-13 Ranganathan, S.,Cheung, J.,Cassidy, M.,Ginter, C.,Pata, J.D.,McDonough, K.A. Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria. Nucleic Acids Res. 2018 46 403 420 5W5B 29165665 Crystal structure of Mycobacterium tuberculosis CRP-FNR family transcription factor Cmr (Rv1675c), truncated construct 2017-06-14 2017-12-13 Ranganathan, S.,Cheung, J.,Cassidy, M.,Ginter, C.,Pata, J.D.,McDonough, K.A. Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria. Nucleic Acids Res. 2018 46 403 420 5TF8 Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dTTP 2016-09-24 2018-05-09 Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain To Be Published 0 0 0 0 5TFA Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dUTP 2016-09-24 2018-05-09 Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain To Be Published 0 0 0 0 5TFB Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with 7-methyl-GTP 2016-09-24 2018-05-09 Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain To Be Published 0 0 0 0 6CG6 29742438 mouse cadherin-10 EC1-2 adhesive fragment 2018-02-19 2018-05-09 Brasch, J.,Katsamba, P.S.,Harrison, O.J.,Ahlsen, G.,Troyanovsky, R.B.,Indra, I.,Kaczynska, A.,Kaeser, B.,Troyanovsky, S.,Honig, B.,Shapiro, L. Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior. Cell Rep 2018 23 1840 1852 6CGS 29742438 mouse cadherin-7 EC1-2 adhesive fragment 2018-02-20 2018-05-09 Brasch, J.,Katsamba, P.S.,Harrison, O.J.,Ahlsen, G.,Troyanovsky, R.B.,Indra, I.,Kaczynska, A.,Kaeser, B.,Troyanovsky, S.,Honig, B.,Shapiro, L. Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior. Cell Rep 2018 23 1840 1852 6CGU 29742438 mouse cadherin-6 EC1-2 adhesive fragment 2018-02-20 2018-05-09 Brasch, J.,Katsamba, P.S.,Harrison, O.J.,Ahlsen, G.,Troyanovsky, R.B.,Indra, I.,Kaczynska, A.,Kaeser, B.,Troyanovsky, S.,Honig, B.,Shapiro, L. Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior. Cell Rep 2018 23 1840 1852 6DDB 29990496 Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target 2018-05-09 2018-07-04 Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 2018 34 136 0 6DDC 29990496 Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target 2018-05-09 2018-07-04 Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 2018 34 136 0 6DDH 29990496 Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target 2018-05-10 2018-07-04 Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 2018 34 136 0 6E12 Crystal Structure of the Alr8543 protein in complex with Oleic Acid and magnesium ion from Nostoc sp. PCC 7120, Northeast Structural Genomics Consortium Target NsR141 2018-07-09 2018-07-25 Forouhar, F.,Neely, H.,Seetharaman, J.,Xiao, R.,Ciccosanti, C.,Patel, D.,Belote, R.L.,Everett, J.K.,Nair, R.,Acton, T.B.,Rost, B.,Montelione, G.T.,Tong, L.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) Crystal Structure of the Alr8543 protein in complex with Oleic Acid and magnesium ion from Nostoc sp. PCC 7120, Northeast Structural Genomics Consortium Target NsR141 To Be Published 0 0 0 0 6E35 Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160 2018-07-13 2018-07-25 Forouhar, F.,Lewis-Ballester, A.,Lew, S.,Karkashon, S.,Seetharaman, J.,Lu, C.,Hussain, M.,Yeh, S.-R.,Tong, L. Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160 To Be Published 0 0 0 0 6OBY 31794207 The nucleotide-binding protein AF_226 in complex with ADP from Archaeoglobus fulgidus with Co found by PIXE. Based on 3KB1. 2019-03-21 2019-12-25 Grime, G.W.,Zeldin, O.B.,Snell, M.E.,Lowe, E.D.,Hunt, J.F.,Montelione, G.T.,Tong, L.,Snell, E.H.,Garman, E.F. High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application. J.Am.Chem.Soc. 2020 142 185 197 6U33 32179646 Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus 2019-08-21 2020-03-25 Liu, J.,Kozhaya, L.,Torres, V.J.,Unutmaz, D.,Lu, M. Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem. 2020 295 5944 5959 6OLU 33275877 RIAM RA-PH core structure in the P212121 space group 2019-04-17 2020-04-22 Cho, E.A.,Zhang, P.,Kumar, V.,Kavalchuk, M.,Zhang, H.,Huang, Q.,Duncan, J.S.,Wu, J. Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. Structure 2021 29 320 0 7N1R 34941000 A novel and unique ATP hydrolysis to AMP by a human Hsp70 BiP 2021-05-28 2022-01-12 Li, H.,Musayev, F.N.,Yang, J.,Su, J.,Liu, Q.,Wang, W.,Fang, X.,Zhou, L.,Liu, Q. A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP). Protein Sci. 2022 31 797 810 8FA4 Crystal structure of Xanthomonas campestris GanA beta-galactosidase 2022-11-25 2023-11-29 Godoy, A.S.,Polikarpov, I. Crystal structure of Xanthomonas campestris GanA beta-galactosidase To Be Published 0 0 0 0 8FA5 Crystal structure of Xanthomonas campestris GH35 beta-galactosidase 2022-11-25 2023-11-29 Godoy, A.S.,Polikarpov, I. Crystal structure of Xanthomonas campestris GanA beta-galactosidase To Be Published 0 0 0 0 8FAA Crystal structure of Xanthomonas campestris GH35 beta-galactosidase 2022-11-25 2023-11-29 Godoy, A.S.,Polikarpov, I. Crystal structure of Xanthomonas campestris GanA beta-galactosidase To Be Published 0 0 0 0