PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 4M2J 24505011 Crystal structure of PLP-dependent cyclase OrfR in complex with Au 2013-08-05 2014-06-18 Chang, C.Y.,Lyu, S.Y.,Liu, Y.C.,Hsu, N.S.,Wu, C.C.,Tang, C.F.,Lin, K.H.,Ho, J.Y.,Wu, C.J.,Tsai, M.D.,Li, T.L. Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl. 2014 53 1943 1948 4M2M 24505011 Crystal structure of PLP-dependent cyclase OrfR in complex with PLP-L-Arg 2013-08-05 2014-06-18 Chang, C.Y.,Lyu, S.Y.,Liu, Y.C.,Hsu, N.S.,Wu, C.C.,Tang, C.F.,Lin, K.H.,Ho, J.Y.,Wu, C.J.,Tsai, M.D.,Li, T.L. Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl. 2014 53 1943 1948 4M27 24505011 Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and L-Arg 2013-08-05 2014-06-25 Chang, C.Y.,Lyu, S.Y.,Liu, Y.C.,Hsu, N.S.,Wu, C.C.,Tang, C.F.,Lin, K.H.,Ho, J.Y.,Wu, C.J.,Tsai, M.D.,Li, T.L. Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl. 2014 53 1943 1948 4M2C 24505011 Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and D-Arg 2013-08-05 2014-06-25 Chang, C.Y.,Lyu, S.Y.,Liu, Y.C.,Hsu, N.S.,Wu, C.C.,Tang, C.F.,Lin, K.H.,Ho, J.Y.,Wu, C.J.,Tsai, M.D.,Li, T.L. Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl. 2014 53 1943 1948 4M2E 24505011 Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and L-homoarginine 2013-08-05 2014-06-25 Chang, C.Y.,Lyu, S.Y.,Liu, Y.C.,Hsu, N.S.,Wu, C.C.,Tang, C.F.,Lin, K.H.,Ho, J.Y.,Wu, C.J.,Tsai, M.D.,Li, T.L. Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl. 2014 53 1943 1948 4OEE 24959968 Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex 2014-01-13 2014-07-09 Li, Y.C.,Ho, I.H.,Ku, C.C.,Zhong, Y.Q.,Hu, Y.P.,Chen, Z.G.,Chen, C.Y.,Lin, W.C.,Zulueta, M.M.,Hung, S.C.,Lin, M.G.,Wang, C.C.,Hsiao, C.D. Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2. Acs Chem.Biol. 2014 9 1712 1717 4CXV 25157844 Structure of bifunctional endonuclease (AtBFN2) in complex with phosphate. 2014-04-09 2014-07-23 Yu, T.,Maestre-Reyna, M.,Ko, C.,Ko, T.,Sun, Y.,Lin, T.,Shaw, J.,Wang, A.H. Structural Insights of the Ssdna Binding Site in the Multifunctional Endonuclease Atbfn2 from Arabidopsis Thaliana. Plos One 2014 9 5821 0 4M8V Crystal structure of Human double mutant beta2-microglobulin Q8H-L65T 2013-08-14 2014-10-15 Lai, M.H.,Wu, P.H.,Li, C.H.,Chang, C.C.,Chen, C.J. Crystal structure of Human double mutant beta2-microglobulin Q8H-L65T To be Published 0 0 0 0 3WUB 25193708 The wild type crystal structure of b-1,4-Xylanase (XynAS9) from Streptomyces sp. 9 2014-04-23 2014-10-29 Chen, C.C.,Luo, H.,Han, X.,Lv, P.,Ko, T.P.,Peng, W.,Huang, C.H.,Wang, K.,Gao, J.,Zheng, Y.,Yang, Y.,Zhang, J.,Yao, B.,Guo, R.T. Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability. J.Biotechnol. 2014 0 175 182 3WUE 25193708 The wild type crystal structure of b-1,4-Xylanase (XynAS9) with xylobiose from Streptomyces sp. 9 2014-04-23 2014-10-29 Chen, C.C.,Luo, H.,Han, X.,Lv, P.,Ko, T.P.,Peng, W.,Huang, C.H.,Wang, K.,Gao, J.,Zheng, Y.,Yang, Y.,Zhang, J.,Yao, B.,Guo, R.T. Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability. J.Biotechnol. 2014 0 175 182 4QUM 25314968 Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide 2014-07-10 2014-12-10 Chen, K.E.,Lin, S.Y.,Wu, M.J.,Ho, M.R.,Santhanam, A.,Chou, C.C.,Meng, T.C.,Wang, A.H.J. Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal. 2014 7 0 0 4RH9 25728925 Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide 2014-10-01 2015-03-11 Chen, K.E.,Li, M.Y.,Chou, C.C.,Ho, M.R.,Chen, G.C.,Meng, T.C.,Wang, A.H. Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure 2015 23 653 664 4RHG 25728925 Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide 2014-10-02 2015-03-11 Chen, K.E.,Li, M.Y.,Chou, C.C.,Ho, M.R.,Chen, G.C.,Meng, T.C.,Wang, A.H. Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure 2015 23 653 664 4RI4 25728925 Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate 2014-10-05 2015-03-11 Chen, K.E.,Li, M.Y.,Chou, C.C.,Ho, M.R.,Chen, G.C.,Meng, T.C.,Wang, A.H. Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure 2015 23 653 664 4RI5 25728925 Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate 2014-10-05 2015-03-11 Chen, K.E.,Li, M.Y.,Chou, C.C.,Ho, M.R.,Chen, G.C.,Meng, T.C.,Wang, A.H. Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. 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Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation. Angew. Chem. Int. Ed. Engl. 2018 57 1831 1835 5WUL 29396495 Serratia marcescens short-chain dehydrogenase/reductase F98A/F202L 2016-12-19 2018-02-28 Liu, J.-S.,Kuan, Y.-C.,Tsou, Y.,Lin, T.-Y.,Hsu, W.-H.,Yang, M.-T.,Lin, J.-Y.,Wang, W.-C. Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine. Sci Rep 2018 8 2316 2316 5WUW 29396495 Serratia marcescens short-chain dehydrogenase/reductase F98L/F202L mutant 2016-12-21 2018-02-28 Liu, J.-S.,Kuan, Y.-C.,Tsou, Y.,Lin, T.-Y.,Hsu, W.-H.,Yang, M.-T.,Lin, J.-Y.,Wang, W.-C. Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine. 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Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex Nucleic Acids Res. 2018 46 7396 7404 5YWT 29734329 Crystal structure of TREX1 in complex with a duplex DNA with 3' overhang 2017-11-30 2018-05-23 Huang, K.W.,Liu, T.C.,Liang, R.Y.,Chu, L.Y.,Cheng, H.L.,Chu, J.W.,Hsiao, Y.Y. Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1 PLoS Biol. 2018 16 0 0 5XPS 30155962 Crystal Structure of Transketolase in complex with erythrose-4-phosphate from Pichia Stipitis 2017-06-04 2018-06-06 Hsu, N.S.,Wang, Y.L.,Lin, K.H.,Chang, C.F.,Ke, S.C.,Lyu, S.Y.,Hsu, L.J.,Li, Y.S.,Chen, S.C.,Wang, K.C.,Li, T.L. Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto-Transferring Reactions. 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Chembiochem 2018 19 2395 2402 5XT0 30155962 Crystal Structure of Transketolase in complex with TPP intermediate VIII from Pichia Stipitis 2017-06-16 2018-06-20 Hsu, N.S.,Wang, Y.L.,Lin, K.H.,Chang, C.F.,Ke, S.C.,Lyu, S.Y.,Hsu, L.J.,Li, Y.S.,Chen, S.C.,Wang, K.C.,Li, T.L. Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto-Transferring Reactions. Chembiochem 2018 19 2395 2402 5XT4 30155962 Crystal Structure of Transketolase in complex with TPP intermediate VIII' from Pichia Stipitis 2017-06-16 2018-06-20 Hsu, N.S.,Wang, Y.L.,Lin, K.H.,Chang, C.F.,Ke, S.C.,Lyu, S.Y.,Hsu, L.J.,Li, Y.S.,Chen, S.C.,Wang, K.C.,Li, T.L. Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto-Transferring Reactions. Chembiochem 2018 19 2395 2402 5Z2G Crystal Structure of L-amino acid oxidase from venom of Naja atra 2018-01-02 2018-06-20 Kumar, J.V.,Chien, K.Y.,Lin, C.C.,Chiang, L.C.,Lin, T.H.,Wu, W.G. 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Cell Rep 2018 24 1996 2004 5YNT 29229390 Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX 1903 2017-10-25 2018-08-29 Wang, J.,Chen, C.C.,Yang, Y.,Liu, W.,Ko, T.P.,Shang, N.,Hu, X.,Xie, Y.,Huang, J.W.,Zhang, Y.,Guo, R.T. Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis. Biochem. Biophys. Res. Commun. 2018 495 1782 1788 5YNU 29229390 Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX 1903 in complex with INN 2017-10-25 2018-08-29 Wang, J.,Chen, C.C.,Yang, Y.,Liu, W.,Ko, T.P.,Shang, N.,Hu, X.,Xie, Y.,Huang, J.W.,Zhang, Y.,Guo, R.T. Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis. Biochem. Biophys. Res. 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Kinetic analysis and structural studies of a high-efficiency laccase fromCerrenasp. RSD1. FEBS Open Bio 2018 8 1230 1246 5ZW0 30095206 Apo-form PigA 2018-05-14 2018-09-05 Lee, C.-C.,Ko, T.-P.,Chen, C.T.,Chan, Y.T.,Lo, S.Y.,Chang, J.Y.,Chen, Y.W.,Chung, T.F.,Hsieh, H.J.,Hsiao, C.D.,Wang, A.H.J. Crystal Structure of PigA: A Prolyl Thioester-Oxidizing Enzyme in Prodigiosin Biosynthesis. Chembiochem 2019 20 193 202 5YKC crystal structure of H5 hemagglutinin from A/chicken/Taiwan/0502/2012 2017-10-13 2018-10-17 Lin, T.H.,Lee, M.S.,Wu, W.G. crystal structure of H5 hemagglutinin from A/chicken/Taiwan/0502/2012 To Be Published 0 0 0 0 5YKZ 30820467 The crystal structure of Penaeus vannamei nodavirus P-domain (P21) 2017-10-16 2018-10-24 Chen, N.C.,Yoshimura, M.,Miyazaki, N.,Guan, H.H.,Chuankhayan, P.,Lin, C.C.,Chen, S.K.,Lin, P.J.,Huang, Y.C.,Iwasaki, K.,Nakagawa, A.,Chan, S.I.,Chen, C.J. The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism. Commun Biol 2019 2 72 72 5YVK 30222239 Crystal structure of a cyclase Famc1 from Fischerella ambigua UTEX 1903 2017-11-26 2018-11-07 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 5YVL 30222239 Crystal structure of a cyclase Hpiu5 from Fischerella sp. ATCC 43239 2017-11-26 2018-11-07 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 5YVP 30222239 Crystal structure of an apo form cyclase Filc1 from Fischerella sp. TAU 2017-11-27 2018-11-07 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 6A46 30357414 Structure of TREX2 in complex with a nucleotide (dCMP) 2018-06-19 2018-11-07 Cheng, H.L.,Lin, C.T.,Huang, K.W.,Wang, S.,Lin, Y.T.,Toh, S.I.,Hsiao, Y.Y. Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res. 2018 46 12166 12176 6A47 30357414 Structure of TREX2 in complex with a Y structured dsDNA 2018-06-19 2018-11-07 Cheng, H.L.,Lin, C.T.,Huang, K.W.,Wang, S.,Lin, Y.T.,Toh, S.I.,Hsiao, Y.Y. 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Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res. 2018 46 12166 12176 5YT8 Crystal structure of H5 hemagglutinin with G228S Q226L mutants from A/chicken/Taiwan/0502/2012 2017-11-17 2018-11-21 Lin, T.H.,Lee, M.S.,Wu, W.G.,Liu, J.S. crystal structure of H5 hemagglutinin from A/chicken/Taiwan/0502/2012 To Be Published 0 0 0 0 5YT9 Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/Taiwan/0502/2012 2017-11-17 2018-11-21 Lin, T.H.,Lee, M.S.,Wu, W.G.,Liu, J.S. crystal structure of H5 hemagglutinin from A/chicken/Taiwan/0502/2012 To Be Published 0 0 0 0 6A8X 30222239 Crystal structure of a apo form cyclase from Fischerella sp. 2018-07-11 2018-12-19 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 6A92 30222239 Crystal structure of a cyclase Filc1 from Fischerella sp. 2018-07-11 2018-12-19 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 6A98 30222239 Crystal structure of a cyclase from Fischerella sp. TAU 2018-07-12 2018-12-19 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 6A99 30222239 Crystal structure of a Stig cyclases Fisc from Fischerella sp. TAU in complex with (3Z)-3-(1-methyl-2-pyrrolidinylidene)-3H-indole 2018-07-12 2018-12-19 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 6A9F 30222239 Crystal structure of a cyclase from Fischerella sp. TAU in complex with 4-(1H-Indol-3-yl)butan-2-one 2018-07-13 2018-12-19 Chen, C.C.,Hu, X.,Tang, X.,Yang, Y.,Ko, T.P.,Gao, J.,Zheng, Y.,Huang, J.W.,Yu, Z.,Li, L.,Han, S.,Cai, N.,Zhang, Y.,Liu, W.,Guo, R.T. The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement Angew. Chem. Int. Ed. Engl. 2018 57 15060 15064 5Z88 Crystal structure of H5 hemagglutinin G228S mutant with 3SLN from A/chicken/Taiwan/0502/2012 2018-01-31 2019-02-06 Lin, T.H.,Lee, M.S.,Wu, W.G.,Liu, J.S. crystal structure of H5 hemagglutinin from A/chicken/Taiwan/0502/2012 To Be Published 0 0 0 0 6IUC 30544248 Structure of Helicobacter pylori Soj-ATP complex bound to DNA 2018-11-28 2019-02-13 Chu, C.H.,Yen, C.Y.,Chen, B.W.,Lin, M.G.,Wang, L.H.,Tang, K.Z.,Hsiao, C.D.,Sun, Y.J. Crystal structures of HpSoj-DNA complexes and the nucleoid-adaptor complex formation in chromosome segregation. Nucleic Acids Res. 2019 47 2113 2129 6IQC 30713157 Wild-type Programmed Cell Death 5 protein from Sulfolobus solfataricus 2018-11-06 2019-02-20 Lin, K.F.,Hsu, J.Y.,Hsieh, D.L.,Tsai, M.J.,Yeh, C.H.,Chen, C.Y. Crystal structure of the programmed cell death 5 protein from Sulfolobus solfataricus. Acta Crystallogr F Struct Biol 2019 75 73 79 5ZDC 30940816 Crystal structure of poly(ADP-ribose) glycohydrolase (PARG) from Deinococcus radiodurans in complex with ADP-ribose (P32) 2018-02-23 2019-02-27 Cho, C.C.,Chien, C.Y.,Chiu, Y.C.,Lin, M.H.,Hsu, C.H. Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans. Nat Commun 2019 10 1491 1491 5ZME 30891827 Nucleotide-free form of C. reinhardtii ArsA1 2018-04-03 2019-03-20 Lin, T.W.,Chen, C.C.,Wu, S.M.,Chang, Y.C.,Li, Y.C.,Su, Y.W.,Hsiao, C.D.,Chang, H.Y. Structural analysis of chloroplast tail-anchored membrane protein recognition by ArsA1. Plant J. 2019 99 128 143 5ZMF 30891827 AMPPNP complex of C. reinhardtii ArsA1 2018-04-03 2019-03-20 Lin, T.W.,Chen, C.C.,Wu, S.M.,Chang, Y.C.,Li, Y.C.,Su, Y.W.,Hsiao, C.D.,Chang, H.Y. Structural analysis of chloroplast tail-anchored membrane protein recognition by ArsA1. Plant J. 2019 99 128 143 6JC5 30836182 Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni 2019-01-28 2019-03-20 Chang, H.Y.,Ko, T.P.,Chang, Y.C.,Huang, K.F.,Lin, C.Y.,Chou, H.Y.,Chiang, C.Y.,Tsai, H.J. Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni. Int. J. Biol. Macromol. 2019 130 675 684 6JC6 30836182 Crystal structure of the purple chromoprotein of Stichodactyla haddoni with a Glu-Tyr-Gly tri-peptide chromophore 2019-01-28 2019-03-20 Chang, H.Y.,Ko, T.P.,Chang, Y.C.,Huang, K.F.,Lin, C.Y.,Chou, H.Y.,Chiang, C.Y.,Tsai, H.J. Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni. Int. J. Biol. Macromol. 2019 130 675 684 6IID 30949702 Human EXOG-H140A in complex with RNA-DNA chimeric duplex 2018-10-04 2019-04-03 Wu, C.C.,Lin, J.L.J.,Yang-Yen, H.F.,Yuan, H.S. A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. Nucleic Acids Res. 2019 47 5405 5419 6ITA 30902636 Crystal structure of intracellular B30.2 domain of BTN3A1 mutant 2018-11-20 2019-04-03 Yang, Y.,Li, L.,Yuan, L.,Zhou, X.,Duan, J.,Xiao, H.,Cai, N.,Han, S.,Ma, X.,Liu, W.,Chen, C.C.,Wang, L.,Li, X.,Chen, J.,Kang, N.,Chen, J.,Shen, Z.,Malwal, S.R.,Liu, W.,Shi, Y.,Oldfield, E.,Guo, R.T.,Zhang, Y. A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation. Immunity 2019 50 1043 0 6J06 30902636 Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with HMBPP-08 2018-12-21 2019-04-03 Yang, Y.,Li, L.,Yuan, L.,Zhou, X.,Duan, J.,Xiao, H.,Cai, N.,Han, S.,Ma, X.,Liu, W.,Chen, C.C.,Wang, L.,Li, X.,Chen, J.,Kang, N.,Chen, J.,Shen, Z.,Malwal, S.R.,Liu, W.,Shi, Y.,Oldfield, E.,Guo, R.T.,Zhang, Y. A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation. Immunity 2019 50 1043 0 6J0K 30902636 Crystal structure of intracellular B30.2 domain of BTN3A3 mutant in complex with HMBPP 2018-12-24 2019-04-03 Yang, Y.,Li, L.,Yuan, L.,Zhou, X.,Duan, J.,Xiao, H.,Cai, N.,Han, S.,Ma, X.,Liu, W.,Chen, C.C.,Wang, L.,Li, X.,Chen, J.,Kang, N.,Chen, J.,Shen, Z.,Malwal, S.R.,Liu, W.,Shi, Y.,Oldfield, E.,Guo, R.T.,Zhang, Y. A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation. Immunity 2019 50 1043 0 6J0L 30902636 Crystal structure of intracellular B30.2 domain of BTN3A3 mutant in complex with sulfate ion 2018-12-24 2019-04-03 Yang, Y.,Li, L.,Yuan, L.,Zhou, X.,Duan, J.,Xiao, H.,Cai, N.,Han, S.,Ma, X.,Liu, W.,Chen, C.C.,Wang, L.,Li, X.,Chen, J.,Kang, N.,Chen, J.,Shen, Z.,Malwal, S.R.,Liu, W.,Shi, Y.,Oldfield, E.,Guo, R.T.,Zhang, Y. A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation. Immunity 2019 50 1043 0 6AFS 30878480 Proton pyrophosphatase - two phosphates-bound 2018-08-08 2019-04-10 Tsai, J.Y.,Tang, K.Z.,Li, K.M.,Hsu, B.L.,Chiang, Y.W.,Goldman, A.,Sun, Y.J. Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol. 2019 431 1619 1632 6AFU 30878480 Proton pyrophosphatase-L555M mutant 2018-08-08 2019-04-10 Tsai, J.Y.,Tang, K.Z.,Li, K.M.,Hsu, B.L.,Chiang, Y.W.,Goldman, A.,Sun, Y.J. Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol. 2019 431 1619 1632 6AFV 30878480 Proton pyrophosphatase-L555K mutant 2018-08-08 2019-04-10 Tsai, J.Y.,Tang, K.Z.,Li, K.M.,Hsu, B.L.,Chiang, Y.W.,Goldman, A.,Sun, Y.J. Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol. 2019 431 1619 1632 6AFW 30878480 Proton pyrophosphatase-T228D mutant 2018-08-08 2019-04-10 Tsai, J.Y.,Tang, K.Z.,Li, K.M.,Hsu, B.L.,Chiang, Y.W.,Goldman, A.,Sun, Y.J. Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol. 2019 431 1619 1632 6AFY 30878480 Proton pyrophosphatase-E225S mutant 2018-08-08 2019-04-10 Tsai, J.Y.,Tang, K.Z.,Li, K.M.,Hsu, B.L.,Chiang, Y.W.,Goldman, A.,Sun, Y.J. Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol. 2019 431 1619 1632 6AFZ 30878480 Proton pyrophosphatase-E225H mutant 2018-08-08 2019-04-10 Tsai, J.Y.,Tang, K.Z.,Li, K.M.,Hsu, B.L.,Chiang, Y.W.,Goldman, A.,Sun, Y.J. Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. J. Mol. Biol. 2019 431 1619 1632 6J8V 30837154 Structure of MOEN5-SSO7D fusion protein in complex with ligand 2 2019-01-21 2019-04-17 Zhang, L.L.,Ko, T.P.,Malwal, S.R.,Liu, W.D.,Zhou, S.Y.,Yu, X.J.,Oldfield, E.,Guo, R.T.,Chen, C.C. Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun. 2019 511 800 805 6J8W 30837154 Structure of MOEN5-SSO7D fusion protein in complex with lig 1 2019-01-21 2019-04-17 Zhang, L.L.,Ko, T.P.,Malwal, S.R.,Liu, W.D.,Zhou, S.Y.,Yu, X.J.,Oldfield, E.,Guo, R.T.,Chen, C.C. Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun. 2019 511 800 805 5ZT2 Crystal structure of CCG DNA repeats at 1.66 angstrom resolution 2018-05-01 2019-05-15 Hou, M.H. Crystallographic analysis of conformational change in CCG repeats into i-motif and unusual DNA duplex in presence and absence of CoII(Chro)2 complex To Be Published 0 0 0 0 5ZLC 31067051 Binary complex of human DNA Polymerase Mu with MndGTP 2018-03-27 2019-05-29 Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D. Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc. 2019 141 8489 8502 5ZXA 31175911 Crystal structure of fibronectin-binding protein Apa mutant from Mycobacterium tuberculosis 2018-05-18 2019-05-29 Kuo, C.J.,Gao, J.,Huang, J.W.,Ko, T.P.,Zhai, C.,Ma, L.,Liu, W.,Dai, L.,Chang, Y.F.,Chen, T.H.,Hu, Y.,Yu, X.,Guo, R.T.,Chen, C.C. Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis. Biochim Biophys Acta Gen Subj 2019 1863 1351 1359 5ZYO 31104814 Crystal Structure of domain-swapped Circular-Permuted YbeA (CP74) from Escherichia coli 2018-05-26 2019-05-29 Ko, K.T.,Hu, I.C.,Huang, K.F.,Lyu, P.C.,Hsu, S.D. Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer. Structure 2019 27 1224 0 6IPI 31067051 Binary Complex of Human DNA Polymerase Mu with MndCTP 2018-11-03 2019-05-29 Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D. Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc. 2019 141 8489 8502 6IPJ 31067051 Binary Complex of Human DNA Polymerase Mu with MndTTP 2018-11-03 2019-05-29 Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D. Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc. 2019 141 8489 8502 5ZZD 30628619 Crystal structure of a protein from Aspergillus flavus 2018-05-31 2019-06-05 Chang, Z.,Ansbacher, T.,Zhang, L.,Yang, Y.,Ko, T.P.,Zhang, G.,Liu, W.,Huang, J.W.,Dai, L.,Guo, R.T.,Major, D.T.,Chen, C.C. Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis. Org.Biomol.Chem. 2019 17 2070 2076 5ZZJ Crystal structure of a enzyme from Santalum album 2018-06-01 2019-06-12 Han, X.,Liu, W.D.,Chen, C.C.,Guo, R.T. Crystal structure of a enzyme from Santalum album to be published 0 0 0 0 5ZZP 31588923 The crystal structure of Mandelate oxidase 2018-06-04 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 5ZZQ 31373572 The crystal structure of Mandelate oxidase with (S)-4-Hydroxymandelic acid 2018-06-04 2019-06-19 Yeh, H.W.,Lin, K.H.,Lyu, S.Y.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallogr D Struct Biol 2019 75 733 742 5ZZR 31588923 The crystal structure of Mandelate oxidase with (S)-mandelic acid 2018-06-04 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 5ZZS 31373572 The crystal structure of Mandelate oxidase with benzoic acid 2018-06-04 2019-06-19 Yeh, H.W.,Lin, K.H.,Lyu, S.Y.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallogr D Struct Biol 2019 75 733 742 5ZZT 32362037 The crystal structure of Mandelate oxidase with 3,3-difluoro-2-hydroxy-3-phenylpropionic acid 2018-06-04 2019-06-19 Lin, K.H.,Lyu, S.Y.,Yeh, H.W.,Li, Y.S.,Hsu, N.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Wang, Z.C.,Wu, C.J.,Li, T.L. Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity. Protein Sci. 2020 29 1655 1666 5ZZZ 31588923 The crystal structure of Mandelate oxidase Y128C with benzoyl-formic acid 2018-06-05 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 6A00 31373572 The crystal structure of Mandelate oxidase with (S)-2-phenylpropionate 2018-06-05 2019-06-19 Yeh, H.W.,Lin, K.H.,Lyu, S.Y.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallogr D Struct Biol 2019 75 733 742 6A01 32362037 The crystal structure of Mandelate oxidase Y128F with 3,3-difluoro-2,2-dihydroxy-3-phenylpropionic acid 2018-06-05 2019-06-19 Lin, K.H.,Lyu, S.Y.,Yeh, H.W.,Li, Y.S.,Hsu, N.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Wang, Z.C.,Wu, C.J.,Li, T.L. Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity. Protein Sci. 2020 29 1655 1666 6A08 31588923 The crystal structure of Mandelate oxidase with benzoyl-formic acid 2018-06-05 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 6A0B 32362037 The crystal structure of Mandelate oxidase mutant Y128F with (R)-3,3,3-trifluoro-2-hydroxy-propionic acid 2018-06-05 2019-06-19 Lin, K.H.,Lyu, S.Y.,Yeh, H.W.,Li, Y.S.,Hsu, N.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Wang, Z.C.,Wu, C.J.,Li, T.L. Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity. Protein Sci. 2020 29 1655 1666 6A0D 31373572 The crystal structure of Mandelate oxidase mutant Y128F with (S)-2-phenylpropanoic acid 2018-06-05 2019-06-19 Yeh, H.W.,Lin, K.H.,Lyu, S.Y.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallogr D Struct Biol 2019 75 733 742 6A0O 31373572 Mandelate oxidase mutant-Y128F with benzaldehyde 2018-06-06 2019-06-19 Yeh, H.W.,Lin, K.H.,Lyu, S.Y.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallogr D Struct Biol 2019 75 733 742 6A0Y 31373572 Mandelate oxidase mutant-Y128F with Benzoic acid 2018-06-06 2019-06-19 Yeh, H.W.,Lin, K.H.,Lyu, S.Y.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallogr D Struct Biol 2019 75 733 742 6A13 31588923 Mandelate oxidase mutant-Y128F 2018-06-06 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 6A19 31588923 Mandelate oxidase mutant-Y128F with Benzoylformic acid 2018-06-06 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 6A1A 31373572 Mandelate oxidase mutant-Y128F with 4-hydroxymandelic acid 2018-06-07 2019-06-19 Yeh, H.W.,Lin, K.H.,Lyu, S.Y.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction. Acta Crystallogr D Struct Biol 2019 75 733 742 6A1B 32362037 Mandelate oxidase mutant-Y128F with 3,3,3-trifluoro-2,2-dihydroxypropanoic acid 2018-06-07 2019-06-19 Lin, K.H.,Lyu, S.Y.,Yeh, H.W.,Li, Y.S.,Hsu, N.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Wang, Z.C.,Wu, C.J.,Li, T.L. Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity. Protein Sci. 2020 29 1655 1666 6A1H 31588923 Mandelate oxidase mutant-Y128F with 5-deazariboflavin mononucleotide 2018-06-07 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 6A1L 31588923 Mandelate oxidase mutant-Y128F with 5-deazariboflavin mononucleotide and benzoic acid 2018-06-07 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 6A1M 31588923 Mandelate oxidase mutant-Y128F with 5-deazariboflavin mononucleotide and benzoylformic acid 2018-06-07 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. Acta Crystallogr D Struct Biol 2019 75 918 929 6A1N 32362037 Mandelate oxidase mutant-Y128F with (2R,3S)-3-fluoro-2-hydroxy-3-phenylpropanoic acid 2018-06-07 2019-06-19 Lin, K.H.,Lyu, S.Y.,Yeh, H.W.,Li, Y.S.,Hsu, N.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Wang, Z.C.,Wu, C.J.,Li, T.L. Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity. Protein Sci. 2020 29 1655 1666 6A1R 31588923 Mandelate oxidase mutant-Y128F with the N5-phenylacetyl-FMN adduct 2018-06-08 2019-06-19 Lyu, S.Y.,Lin, K.H.,Yeh, H.W.,Li, Y.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Hsu, N.S.,Wu, C.J.,Li, T.L. The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level. 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Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun. 2021 551 33 37 6L0H 33714757 Crystal structure of dihydroorotase in complex with malate at pH7 from Saccharomyces cerevisiae 2019-09-26 2020-12-02 Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y. Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun. 2021 551 33 37 6L0I 33714757 Crystal structure of dihydroorotase in complex with malate at pH6.5 from Saccharomyces cerevisiae 2019-09-26 2020-12-02 Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y. Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. 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Expanding the Substrate Specificity of Macro Domains toward 3''-Isomer of O-Acetyl-ADP-ribose Acs Catalysis 2021 11 11075 11090 6LX0 33094809 Structure of Leptospira santarosai serovar shermani LRR protein LSS11580 2020-02-10 2020-12-23 Hsu, S.H.,Chu, C.H.,Tian, Y.C.,Chang, M.Y.,Chou, L.F.,Sun, Y.J.,Yang, C.W. Crystal structure of Leptospira leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells. Biochem.J. 2020 477 4313 4326 7DD0 33360015 Crystal structure of the N-terminal domain of TagH from Bacillus subtilis 2020-10-27 2020-12-23 Yang, C.S.,Huang, W.C.,Ko, T.P.,Wang, Y.C.,Wang, A.H.,Chen, Y. Crystal structure of the N-terminal domain of TagH reveals a potential drug targeting site. Biochem.Biophys.Res.Commun. 2020 536 1 6 6L75 33836081 Crystal structure of d(GTGGGCCGAC)2 DNA duplex 2019-10-31 2021-01-13 Jhan, C.R.,Satange, R.,Wang, S.C.,Zeng, J.Y.,Horng, Y.C.,Jin, P.,Neidle, S.,Hou, M.H. Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Res. 2021 49 9526 9538 6L76 33836081 Crystal structure of the Ni(II)(Chro)2-d(TTGGGCCGAA/TTCGGCCCAA) complex at 2.94 angstrom resolution 2019-10-31 2021-01-13 Jhan, C.R.,Satange, R.,Wang, S.C.,Zeng, J.Y.,Horng, Y.C.,Jin, P.,Neidle, S.,Hou, M.H. Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Res. 2021 49 9526 9538 6LNH Crystal structure of IDO from Bacillus thuringiensis 2019-12-30 2021-01-13 Feng, Y.,Huang, J.W.,Liu, W.D.,Chen, C.C.,Guo, R.T. Crystal structure of IDO from Bacillus thuringiensis to be published 0 0 0 0 6M2O 32397467 Double mutant(H333A/I334A) crystal structure of benzoate coenzyme A ligase 2020-02-28 2021-01-13 Adhikari, K.,Lo, I.W.,Chen, C.L.,Wang, Y.L.,Lin, K.H.,Zadeh, S.M.,Rattinam, R.,Li, Y.S.,Wu, C.J.,Li, T.L. Chemoenzymatic Synthesis and Biological Evaluation for Bioactive Molecules Derived from Bacterial Benzoyl Coenzyme A Ligase and Plant Type III Polyketide Synthase. Biomolecules 2020 10 0 0 6M2U 32397467 The crystal structure of benzoate coenzyme A ligase double mutant (H333A/I334A) in complex with 2-chloro-1,3-thiazole-5-carboxylate-AMP 2020-02-29 2021-01-13 Adhikari, K.,Lo, I.W.,Chen, C.L.,Wang, Y.L.,Lin, K.H.,Zadeh, S.M.,Rattinam, R.,Li, Y.S.,Wu, C.J.,Li, T.L. Chemoenzymatic Synthesis and Biological Evaluation for Bioactive Molecules Derived from Bacterial Benzoyl Coenzyme A Ligase and Plant Type III Polyketide Synthase. Biomolecules 2020 10 0 0 7D6A 33471829 Crystal structure of Oryza sativa Os4BGlu18 monolignol beta-glucosidase 2020-09-29 2021-01-13 Baiya, S.,Pengthaisong, S.,Kitjaruwankul, S.,Ketudat Cairns, J.R. Structural analysis of rice Os4BGlu18 monolignol beta-glucosidase. 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The crystal structure of benzoate coenzyme A ligase double mutant (H333A/I334A) in complex with 2-methyl-thiazole-5 carboxylate-AMP To Be Published 0 0 0 0 7D4J 33836064 ddATP complex of cyclic trinucleotide synthase CdnD 2020-09-24 2021-03-17 Ko, T.P.,Wang, Y.C.,Tsai, C.L.,Yang, C.S.,Hou, M.H.,Chen, Y. Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase. Nucleic Acids Res. 2021 49 4725 4737 7D4O 33836064 cyclic trinucleotide synthase CdnD in complex with ATP and ADP 2020-09-24 2021-03-17 Ko, T.P.,Wang, Y.C.,Tsai, C.L.,Yang, C.S.,Hou, M.H.,Chen, Y. Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase. Nucleic Acids Res. 2021 49 4725 4737 7D4S 33836064 apo-form cyclic trinucleotide synthase CdnD 2020-09-24 2021-03-17 Ko, T.P.,Wang, Y.C.,Tsai, C.L.,Yang, C.S.,Hou, M.H.,Chen, Y. Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase. Nucleic Acids Res. 2021 49 4725 4737 7D4U 33836064 ATP complex with double mutant cyclic trinucleotide synthase CdnD 2020-09-24 2021-03-17 Ko, T.P.,Wang, Y.C.,Tsai, C.L.,Yang, C.S.,Hou, M.H.,Chen, Y. Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase. Nucleic Acids Res. 2021 49 4725 4737 7D18 33774034 Crystal structure of Acidobacteriales bacterium glutaminyl cyclase 2020-09-14 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D1B 33774034 Crystal structure of Fimbriiglobus ruber glutaminyl cyclase 2020-09-14 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D1H 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with D238A mutation 2020-09-14 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D1N 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with three Cu ions bound to the active site 2020-09-15 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D1P 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with three Cd ions bound to the active site 2020-09-15 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D1Y 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with two Co ions bound to the active site 2020-09-15 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D21 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with two Zn ions bound to the active site 2020-09-15 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D23 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with one K ion bound to the active site 2020-09-15 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D2B 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with a Ni ion bound to the active site 2020-09-16 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes. J.Mol.Biol. 2021 433 166960 166960 7D2D 33774034 Crystal structure of Ixodes scapularis glutaminyl cyclase with a Mn ion bound to the active site 2020-09-16 2021-04-14 Huang, K.F.,Huang, J.S.,Wu, M.L.,Hsieh, W.L.,Hsu, K.C.,Hsu, H.L.,Ko, T.P.,Wang, A.H. 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Nat Catal 2021 4 425 430 7CDL 33629832 holo-methanol dehydrogenase (MDH) with Cys131-Cys132 reduced from Methylococcus capsulatus (Bath) 2020-06-20 2021-06-23 Chan, S.I.,Chuankhayan, P.,Reddy Nareddy, P.K.,Tsai, I.K.,Tsai, Y.F.,Chen, K.H.,Yu, S.S.,Chen, C.J. Mechanism of Pyrroloquinoline Quinone-Dependent Hydride Transfer Chemistry from Spectroscopic and High-Resolution X-ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath). J.Am.Chem.Soc. 2021 143 3359 3372 7DKS 34019851 Crystal structure of TxGH116 E441A nucleophile mutant from Thermoanaerobacterium xylanolyticum 2020-11-25 2021-06-23 Pengthaisong, S.,Hua, Y.,Ketudat Cairns, J.R. Structural basis for transglycosylation in glycoside hydrolase family GH116 glycosynthases. 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Characterization of Enzymes Catalyzing the Formation of the Nonproteinogenic Amino Acid l-Dap in Capreomycin Biosynthesis. Biochemistry 2021 60 77 84 7DRY Crystal structure of Aspergillus oryzae Rib2 deaminase 2020-12-30 2021-07-14 Chen, S.C.,Ye, L.C.,Yen, T.M.,Zhu, R.X.,Li, C.Y.,Chang, S.C.,Liaw, S.H.,Hsu, C.H. Crystal structures of Aspergillus oryzae Rib2 deaminase: the functional mechanism involved in riboflavin biosynthesis. Iucrj 2021 8 549 558 7DRZ Crystal structure of Aspergillus oryzae Rib2 deaminase (C-terminal deletion mutant) at pH 4.6 2020-12-30 2021-07-14 Chen, S.C.,Ye, L.C.,Yen, T.M.,Zhu, R.X.,Li, C.Y.,Chang, S.C.,Liaw, S.H.,Hsu, C.H. Crystal structures of Aspergillus oryzae Rib2 deaminase: the functional mechanism involved in riboflavin biosynthesis. Iucrj 2021 8 549 558 7DS0 Crystal structure of Aspergillus oryzae Rib2 deaminase (C-terminal deletion mutant) at pH 6.5 2020-12-30 2021-07-14 Chen, S.C.,Ye, L.C.,Yen, T.M.,Zhu, R.X.,Li, C.Y.,Chang, S.C.,Liaw, S.H.,Hsu, C.H. 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Crystal structure of SARS-CoV-2 main protease in complex with Z-IETD-FMK To Be Published 0 0 0 0 7WQK wild-type SARS-CoV-2 main protease in complex with MG-132 2022-01-25 2023-08-02 Wang, Y.C.,Yang, C.S.,Hou, M.H.,Tsai, C.L.,Chen, Y. wild-type SARS-CoV-2 main protease in complex with MG-132 To Be Published 0 0 0 0 7YM1 37834349 Structure of SsbA protein in complex with the anticancer drug 5-fluorouracil 2022-07-27 2023-08-02 Su, H.H.,Huang, Y.H.,Lien, Y.,Yang, P.C.,Huang, C.Y. Crystal Structure of DNA Replication Protein SsbA Complexed with the Anticancer Drug 5-Fluorouracil. Int J Mol Sci 2023 24 0 0 8GR7 37566786 Cop4 from Antrodia cinnamomea in complex with pyrophosphate and magnesium 2022-09-01 2023-09-06 Chen, S.C.,Jiang, B.C.,Lu, Y.J.,Chang, C.H.,Wu, T.H.,Lin, S.W.,Yin, H.W.,Lee, T.H.,Hsu, C.H. Characterization and Crystal Structures of a Cubebol-Producing Sesquiterpene Synthase from Antrodia cinnamomea . J.Agric.Food Chem. 2023 71 13014 13023 8GUF Crystal structure of cyclic B subunit of type II heat labile enterotoxin 2022-09-12 2023-09-20 Peng, Y.J.,Wu, C.Y.,Sue, S.C. Crystal structure of cyclic B subunit of type II heat labile enterotoxin To Be Published 0 0 0 0 8IKR 37830798 Crystal structure of DpaA 2023-03-01 2023-10-11 Wang, H.J.,Hernandez-Rocamora, V.M.,Kuo, C.I.,Hsieh, K.Y.,Lee, S.H.,Ho, M.R.,Tu, Z.,Vollmer, W.,Chang, C.I. Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun's lipoprotein from peptidoglycan. Mbio 2023 14 0 0 8KE1 37904728 PylRS C-terminus domain mutant bound with L-3-bromophenylalanine and AMPNP 2023-08-11 2023-11-01 Jiang, H.K.,Weng, J.H.,Wang, Y.H.,Tsou, J.C.,Chen, P.J.,Ko, A.A.,Soll, D.,Tsai, M.D.,Wang, Y.S. Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet 2023 14 1277489 1277489 8KE2 37904728 PylRS C-terminus domain mutant bound with L-3-trifluoromethylphenylalanine and AMPNP 2023-08-11 2023-11-01 Jiang, H.K.,Weng, J.H.,Wang, Y.H.,Tsou, J.C.,Chen, P.J.,Ko, A.A.,Soll, D.,Tsai, M.D.,Wang, Y.S. Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet 2023 14 1277489 1277489 8KE3 37904728 PylRS C-terminus domain mutant bound with D-3-trifluoromethylphenylalanine and AMPNP 2023-08-11 2023-11-01 Jiang, H.K.,Weng, J.H.,Wang, Y.H.,Tsou, J.C.,Chen, P.J.,Ko, A.A.,Soll, D.,Tsai, M.D.,Wang, Y.S. Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet 2023 14 1277489 1277489 8KE4 37904728 PylRS C-terminus domain mutant bound with D-3-bromophenylalanine and AMPNP 2023-08-11 2023-11-01 Jiang, H.K.,Weng, J.H.,Wang, Y.H.,Tsou, J.C.,Chen, P.J.,Ko, A.A.,Soll, D.,Tsai, M.D.,Wang, Y.S. Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet 2023 14 1277489 1277489 8KE5 37904728 PylRS C-terminus domain mutant bound with D-3-chlorophenylalanine and AMPNP 2023-08-11 2023-11-01 Jiang, H.K.,Weng, J.H.,Wang, Y.H.,Tsou, J.C.,Chen, P.J.,Ko, A.A.,Soll, D.,Tsai, M.D.,Wang, Y.S. Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet 2023 14 1277489 1277489 8KE6 37904728 PylRS C-terminus domain mutant bound with L-3-chlorophenylalanine and AMPNP 2023-08-11 2023-11-01 Jiang, H.K.,Weng, J.H.,Wang, Y.H.,Tsou, J.C.,Chen, P.J.,Ko, A.A.,Soll, D.,Tsai, M.D.,Wang, Y.S. Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet 2023 14 1277489 1277489 8HCC 37870446 Crystal structure of mTREX1-RNA product complex (AMP) 2022-11-01 2023-11-08 Huang, K.W.,Wu, C.Y.,Toh, S.I.,Liu, T.C.,Tu, C.I.,Lin, Y.H.,Cheng, A.J.,Kao, Y.T.,Chu, J.W.,Hsiao, Y.Y. Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res. 2023 51 11927 11940 8INI 37975688 vaccinia H2 protein without the transmembrane region 2023-03-10 2023-11-15 Kao, C.F.,Liu, C.Y.,Hsieh, C.L.,Carillo, K.J.D.,Tzou, D.L.M.,Wang, H.C.,Chang, W. Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex. J.Virol. 2023 97 0 0 8I80 38114770 Crystal structure of Cph001-D189N 2023-02-02 2024-01-10 Toh, S.I.,Elaine Keisha, J.,Wang, Y.L.,Pan, Y.C.,Jhu, Y.H.,Hsiao, P.Y.,Liao, W.T.,Chen, P.Y.,Ko, T.M.,Chang, C.Y. Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin. 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J.Biol.Chem. 2023 300 105553 105553 8IWC 38072060 Crystal structure of Q9PR55 at pH 6.0 2023-03-29 2024-02-07 Hsu, M.F.,Sriramoju, M.K.,Lai, C.H.,Chen, Y.R.,Huang, J.S.,Ko, T.P.,Huang, K.F.,Hsu, S.D. Structure, dynamics, and stability of the smallest and most complex 7 1 protein knot. J.Biol.Chem. 2023 300 105553 105553 8W68 38072060 Crystal structure of Q9PR55 at pH 6.0 (use NMR model) 2023-08-28 2024-02-07 Hsu, M.F.,Sriramoju, M.K.,Lai, C.H.,Chen, Y.R.,Huang, J.S.,Ko, T.P.,Huang, K.F.,Hsu, S.D. Structure, dynamics, and stability of the smallest and most complex 7 1 protein knot. J.Biol.Chem. 2023 300 105553 105553 8IQ9 38349137 Crystal structure of trimeric K2-2 TSP in complex with tetrasaccharide and octasaccharide 2023-03-16 2024-02-21 Ye, T.-J.,Fung, K.-M.,Lee, I.-M.,Ko, T.-P.,Lin, C.-Y.,Wong, C.-L.,Tu, I.-F.,Huang, T.-Y.,Yang, F.-L.,Chang, Y.-P.,Wang, J.-T.,Lin, T.-L.,Huang, K.-F.,Wu, S.-H. Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation. Mbio 2024 0 0 0