PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 5XH2 29235460 Crystal structure of a novel PET hydrolase R103G/S131A mutant in complex with pNP from Ideonella sakaiensis 201-F6 2017-04-19 2017-12-20 Han, X.,Liu, W.,Huang, J.W.,Ma, J.,Zheng, Y.,Ko, T.P.,Xu, L.,Cheng, Y.S.,Chen, C.C.,Guo, R.T. Structural insight into catalytic mechanism of PET hydrolase Nat Commun 2017 8 2106 2106 5XH3 29235460 Crystal structure of a novel PET hydrolase R103G/S131A mutant in complex with HEMT from Ideonella sakaiensis 201-F6 2017-04-19 2017-12-20 Han, X.,Liu, W.,Huang, J.W.,Ma, J.,Zheng, Y.,Ko, T.P.,Xu, L.,Cheng, Y.S.,Chen, C.C.,Guo, R.T. 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A structural model for (GlcNAc) 2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria. J.Biol.Chem. 2021 297 101071 101071 6LZU 34400168 F411A mutant of chitin-specific solute binding protein from Vibrio harveyi co-crystalized with chitobiose. 2020-02-19 2021-02-24 Kitaoku, Y.,Fukamizo, T.,Kumsaoad, S.,Ubonbal, P.,Robinson, R.C.,Suginta, W. A structural model for (GlcNAc) 2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria. J.Biol.Chem. 2021 297 101071 101071 6LZV 34400168 F437A mutant of chitin-specific solute binding protein from Vibrio harveyi co-crystalized with chitobiose. 2020-02-19 2021-02-24 Kitaoku, Y.,Fukamizo, T.,Kumsaoad, S.,Ubonbal, P.,Robinson, R.C.,Suginta, W. A structural model for (GlcNAc) 2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria. 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Iscience 2021 24 102423 102423 7DEY 33884665 Structure of Dicer from Pichia stipitis 2020-11-05 2021-05-05 Chan, J.,Qinqin, F.,Jianwei, L.,Ying, C.,Machida, S.,Wei, C.,Yuan, Y.A.,Jobichen, C. Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer. Protein Sci. 2021 30 1210 1220 7CMA 32828542 Structure of A151R from African swine fever virus Georgia 2020-07-26 2021-06-02 Huang, J.W.,Niu, D.,Liu, K.,Wang, Q.,Ma, L.,Chen, C.C.,Zhang, L.,Liu, W.,Zhou, S.,Min, J.,Wu, S.,Yang, Y.,Guo, R.T. Structure basis of non-structural protein pA151R from African Swine Fever Virus. Biochem.Biophys.Res.Commun. 2020 532 108 113 7CEB 34188035 Crystal structure of alpha6beta1 integrin headpiece 2020-06-22 2021-06-23 Arimori, T.,Miyazaki, N.,Mihara, E.,Takizawa, M.,Taniguchi, Y.,Cabanas, C.,Sekiguchi, K.,Takagi, J. Structural mechanism of laminin recognition by integrin. Nat Commun 2021 12 4012 4012 7CF7 Crystal Structure of YbeA CP74 W72F 2020-06-24 2021-06-30 Liu, C.Y.,Lai, C.H.,Hsu, S.T.D.,Lyu, P.C. Crystal Structure of YbeA CP74 W72F To Be Published 0 0 0 0 7CFY Crystal Structure of YbeA CP74 W48F 2020-06-29 2021-06-30 Liu, C.Y.,Lai, C.H.,Hsu, S.T.D.,Lyu, P.C. Crystal Structure of YbeA CP74 W48F To Be Published 0 0 0 0 7CIU Crystal Structure of Agmatine N-Acetyltransferase mutant S171A apo form 2020-07-08 2021-07-21 Chen, J.J.,Hu, I.C.,Lai, C.H.,Lyu, P.C. Crystal Structure of Agmatine N-Acetyltransferase mutant S171A To Be Published 0 0 0 0 7EHJ 34337952 human MTHFD2 in complex with compound 21, cofactor and phosphate. 2021-03-29 2021-08-11 Lee, L.C.,Peng, Y.H.,Chang, H.H.,Hsu, T.,Lu, C.T.,Huang, C.H.,Hsueh, C.C.,Kung, F.C.,Kuo, C.C.,Jiaang, W.T.,Wu, S.Y. Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). 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Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP and inhibitor carbidopa to be published 0 0 0 0 7CX1 Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP and inhibitor methyl-tyrosine 2020-09-01 2021-09-01 Yu, X.,Gong, M.,Huang, J.,Liu, W.,Chen, C.,Guo, R. Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP and inhibitor methyl-tyrosine to be published 0 0 0 0 7EBI 34400168 Chitin-specific solute binding protein from Vibrio harveyi co-crystalized with chitotetraose. 2021-03-09 2021-09-08 Kitaoku, Y.,Fukamizo, T.,Kumsaoad, S.,Ubonbal, P.,Robinson, R.C.,Suginta, W. A structural model for (GlcNAc) 2 translocation via a periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria. 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Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog To Be Published 0 0 0 0 7DP5 Crystal structure of mutant V45A Brugia malayi thymidylate synthase complexed with 2'-deoxyuridine monophosphate and methotrexate 2020-12-18 2021-12-22 Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B. Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog To Be Published 0 0 0 0 7DP6 Crystal structure of mutant V45T Brugia malayi thymidylate synthase complexed with 2'-deoxyuridine monophosphate 2020-12-18 2021-12-22 Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B. 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Nucleic Acids Res. 2022 50 8867 8881 7UX5 36534810 Structure of PDL1 in complex with FP28136, a Helicon Polypeptide 2022-05-05 2022-12-28 Li, K.,Tokareva, O.S.,Thomson, T.M.,Wahl, S.C.T.,Travaline, T.L.,Ramirez, J.D.,Choudary, S.K.,Agarwal, S.,Walkup 4th, W.G.,Olsen, T.J.,Brennan, M.J.,Verdine, G.L.,McGee, J.H. De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7UXQ 36534810 Structure of PDL1 in complex with FP28135, a Helicon Polypeptide 2022-05-05 2022-12-28 Li, K.,Tokareva, O.S.,Thomson, T.M.,Wahl, S.C.T.,Travaline, T.L.,Ramirez, J.D.,Choudary, S.K.,Agarwal, S.,Walkup 4th, W.G.,Olsen, T.J.,Brennan, M.J.,Verdine, G.L.,McGee, J.H. De novo mapping of alpha-helix recognition sites on protein surfaces using unbiased libraries. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7XCN 36646841 Crystal structure of the MttB-MttC complex at 2.7 A resolution 2022-03-24 2023-01-18 Li, J.,Kang, P.T.,Jiang, R.,Lee, J.Y.,Soares, J.A.,Krzycki, J.A.,Chan, M.K. Insights into pyrrolysine function from structures of a trimethylamine methyltransferase and its corrinoid protein complex. Commun Biol 2023 6 54 54 7WQQ Retinoic acid receptor alpha mutant - N299H 2022-01-25 2023-01-25 Huang, X.X.,Ng, L.M.,Teh, B.T. Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling To Be Published 0 0 0 0 8HYG Crystal structure of protease-associated domain of Arabidopsis vacuolar sorting receptor 1 at pH 4.6 2023-01-06 2023-01-25 Tsao, H.E.,Lui, S.N.,Wong, K.B. Crystal structure of protease-associated domain of Arabidopsis vacuolar sorting receptor 1 at pH 4.6 To Be Published 0 0 0 0 7WUL Crystal structure of UBR bof from PRT6 (RDG pH5.5) 2022-02-08 2023-02-08 Ho, M.C.,Cao, J.J. Crystal structure of UBR box from PRT6 To Be Published 0 0 0 0 7WUM Crystal structure of UBR box from PRT6 (RDG pH 8.5) 2022-02-08 2023-02-08 Ho, M.C.,Cao, C.C. Crystal structure of UBR box from PRT6 To Be Published 0 0 0 0 8H9D 36917574 Crystal structure of Cas12a protein 2022-10-25 2023-02-08 Jianwei, L.,Jobichen, C.,Machida, S.,Meng, S.,Read, R.J.,Hongying, C.,Jian, S.,Yuan, Y.A.,Sivaraman, J. Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage. Plos Biol. 2023 21 0 0 7XBS 36278314 Crystal structure of the adenylation domain of CmnG 2022-03-22 2023-03-01 Chen, I.H.,Cheng, T.,Wang, Y.L.,Huang, S.J.,Hsiao, Y.H.,Lai, Y.T.,Toh, S.I.,Chu, J.,Rudolf, J.D.,Chang, C.Y. Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis. Chembiochem 2022 23 0 0 7XBT 36278314 Crystal structure of the adenylation domain of CmnG in complex with AMP 2022-03-22 2023-03-01 Chen, I.H.,Cheng, T.,Wang, Y.L.,Huang, S.J.,Hsiao, Y.H.,Lai, Y.T.,Toh, S.I.,Chu, J.,Rudolf, J.D.,Chang, C.Y. Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis. Chembiochem 2022 23 0 0 7XBU 36278314 Crystal structure of the adenylation domain of CmnG in complex with capreomycidine 2022-03-22 2023-03-01 Chen, I.H.,Cheng, T.,Wang, Y.L.,Huang, S.J.,Hsiao, Y.H.,Lai, Y.T.,Toh, S.I.,Chu, J.,Rudolf, J.D.,Chang, C.Y. 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Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun 2023 14 5078 5078 7X4C 37604815 Native CD-NTase EfCdnE 2022-03-02 2023-03-08 Yang, C.S.,Ko, T.P.,Chen, C.J.,Hou, M.H.,Wang, Y.C.,Chen, Y. Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun 2023 14 5078 5078 7X4F 37604815 Native CD-NTase LpCdnE 2022-03-02 2023-03-08 Yang, C.S.,Ko, T.P.,Chen, C.J.,Hou, M.H.,Wang, Y.C.,Chen, Y. Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun 2023 14 5078 5078 7X4G 37604815 CD-NTase ClCdnE in complex with substrate UTP 2022-03-02 2023-03-08 Yang, C.S.,Ko, T.P.,Chen, C.J.,Hou, M.H.,Wang, Y.C.,Chen, Y. Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun 2023 14 5078 5078 7X4P 37604815 CD-NTase EfCdnE in complex with intermediate pppUpU 2022-03-03 2023-03-08 Yang, C.S.,Ko, T.P.,Chen, C.J.,Hou, M.H.,Wang, Y.C.,Chen, Y. Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun 2023 14 5078 5078 7X4T 37604815 LpCdnE UMPNPP Mg complex 2022-03-03 2023-03-08 Yang, C.S.,Ko, T.P.,Chen, C.J.,Hou, M.H.,Wang, Y.C.,Chen, Y. Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases. Nat Commun 2023 14 5078 5078 7X5P Truncated VhChiP (1-19aa) in complex with doxycycline 2022-03-05 2023-03-08 Aunkham, A.,Sanram, S.,Suginta, W. Structure and function of truncated VhChiP To Be Published 0 0 0 0 7X5Q 37394001 Apo Truncated VhChiP (Delta 1-19) in complex with peptide (DGANSDAAK) 2022-03-05 2023-03-08 Sanram, S.,Aunkham, A.,Robinson, R.,Suginta, W. Structural displacement model of chitooligosaccharide transport through chitoporin. J.Biol.Chem. 2023 299 105000 105000 8IA4 38627399 Crystal structure of Cas2 in complex with AcrVA5-peptide 2023-02-07 2023-03-22 Bi, M.,Su, W.,Li, J.,Mo, X. Insights into the inhibition of protospacer integration via direct interaction between Cas2 and AcrVA5. Nat Commun 2024 15 3256 3256 7YQN 36997036 Crystal structure of Ecoli malate synthase G 2022-08-08 2023-03-29 Ho, M.R.,Wu, Y.M.,Lu, Y.C.,Ko, T.P.,Wu, K.P. Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G. J.Struct.Biol. 2023 215 107958 107958 7XGS Short vegetative phase protein 2022-04-06 2023-04-12 Pan, Z.-J.,Huang, Y.-C.,Cheng, H.-P.,Lin, C.-P.,Liao, Y.-T.,Ko, T.-P.,Wang, H.-C.,Lin, S.-S. The PHYL1 effector of peanut witches broom (PnWB) phytoplasma alters the miR156/157-mediated squamosa promoter binding protein like regulation and gibberellic acid generation to promote anthocyanin biosynthesis To Be Published 0 0 0 0 8HHG 37019934 The bacterial divisome protein complex FtsB-FtsL-FtsQ 2022-11-16 2023-04-26 Nguyen, H.T.V.,Chen, X.,Parada, C.,Luo, A.C.,Shih, O.,Jeng, U.S.,Huang, C.Y.,Shih, Y.L.,Ma, C. Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome. Nat Commun 2023 14 1903 1903 8HHH 37019934 The bacterial divisome protein complex FtsB-FtsL-FtsQ 2022-11-16 2023-04-26 Nguyen, H.T.V.,Chen, X.,Parada, C.,Luo, A.C.,Shih, O.,Jeng, U.S.,Huang, C.Y.,Shih, Y.L.,Ma, C. Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome. Nat Commun 2023 14 1903 1903 7WZZ 37296297 Crystal structure of peptide KAGQVVTIW in complex with HLA-B5801 2022-02-20 2023-05-03 Huan, X.,Zhuo, N.,Lee, H.Y.,Ren, E.C. Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep 2023 13 9373 9373 7X00 37296297 Crystal structure of peptide VSFIEFVGW in complex with HLA-B5801 2022-02-20 2023-05-03 Huan, X.,Zhuo, N.,Lee, H.Y.,Ren, E.C. Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep 2023 13 9373 9373 7X1B 37296297 Crystal structure of peptide KAGQVVTI in complex with HLA-B5801 2022-02-23 2023-05-03 Huan, X.,Zhuo, N.,Lee, H.Y.,Ren, E.C. Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep 2023 13 9373 9373 7X1C 37296297 Crystal structure of peptide VSFIEFVI in complex with HLA-B5801 2022-02-23 2023-05-03 Huan, X.,Zhuo, N.,Lee, H.Y.,Ren, E.C. Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01. Sci Rep 2023 13 9373 9373 7XJW 35628479 Crystal structure of canine coronavirus main protease in complex with GC376 2022-04-18 2023-05-31 Ho, C.Y.,Yu, J.X.,Wang, Y.C.,Lin, Y.C.,Chiu, Y.F.,Gao, J.Y.,Lai, S.J.,Chen, M.J.,Huang, W.C.,Tien, N.,Chen, Y. A Structural Comparison of SARS-CoV-2 Main Protease and Animal Coronaviral Main Protease Reveals Species-Specific Ligand Binding and Dimerization Mechanism. Int J Mol Sci 2022 23 0 0 7XQA 37137912 Orf1-glycine complex 2022-05-07 2023-05-31 Wang, Y.L.,Chang, C.Y.,Hsu, N.S.,Lo, I.W.,Lin, K.H.,Chen, C.L.,Chang, C.F.,Wang, Z.C.,Ogasawara, Y.,Dairi, T.,Maruyama, C.,Hamano, Y.,Li, T.L. N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. Nat Commun 2023 14 2528 2528 7XXD 37137912 Orf1-sarcosine complex 2022-05-29 2023-05-31 Wang, Y.L.,Chang, C.Y.,Hsu, N.S.,Lo, I.W.,Lin, K.H.,Chen, C.L.,Chang, C.F.,Wang, Z.C.,Ogasawara, Y.,Dairi, T.,Maruyama, C.,Hamano, Y.,Li, T.L. N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. Nat Commun 2023 14 2528 2528 7XXM 37137912 Orf1-glycine-4-aminobutylthricin complex 2022-05-30 2023-05-31 Wang, Y.L.,Chang, C.Y.,Hsu, N.S.,Lo, I.W.,Lin, K.H.,Chen, C.L.,Chang, C.F.,Wang, Z.C.,Ogasawara, Y.,Dairi, T.,Maruyama, C.,Hamano, Y.,Li, T.L. N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. Nat Commun 2023 14 2528 2528 7XXP 37137912 F316A-glycine-streptothricin F complex 2022-05-30 2023-05-31 Wang, Y.L.,Chang, C.Y.,Hsu, N.S.,Lo, I.W.,Lin, K.H.,Chen, C.L.,Chang, C.F.,Wang, Z.C.,Ogasawara, Y.,Dairi, T.,Maruyama, C.,Hamano, Y.,Li, T.L. N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. Nat Commun 2023 14 2528 2528 7XYE 37137912 The apo structure of Orf1 2022-06-01 2023-05-31 Wang, Y.L.,Chang, C.Y.,Hsu, N.S.,Lo, I.W.,Lin, K.H.,Chen, C.L.,Chang, C.F.,Wang, Z.C.,Ogasawara, Y.,Dairi, T.,Maruyama, C.,Hamano, Y.,Li, T.L. N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. 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Structural and functional insights into the self-sufficient flavin-dependent halogenase. Int.J.Biol.Macromol. 2024 260 129312 129312 8JZ5 38216020 Crystal structure of AetF in complex with FAD and NADP+ at 1.86 angstrom 2023-07-04 2024-01-17 Dai, L.,Li, H.,Dai, S.,Zhang, Q.,Zheng, H.,Hu, Y.,Guo, R.T.,Chen, C.C. Structural and functional insights into the self-sufficient flavin-dependent halogenase. Int.J.Biol.Macromol. 2024 260 129312 129312 8IV3 38234090 Crystal structure of SARS-CoV2 N-NTD complexed with 5-Benzyloxygramine 2023-03-25 2024-02-07 Hong, J.Y.,Lin, S.C.,Kehn-Hall, K.,Zhang, K.M.,Luo, S.Y.,Wu, H.Y.,Chang, S.Y.,Hou, M.H. Targeting protein-protein interaction interfaces with antiviral N protein inhibitor in SARS-CoV-2. Biophys.J. 2024 123 478 488 8JA1 38418525 ASFV Topoisomerase ATPase domain in complex with AMP-PNP and Mg2+ (oxidized form) 2023-05-05 2024-02-07 Chang, C.M.,Wang, S.C.,Wang, C.H.,Pang, A.H.,Yang, C.H.,Chang, Y.K.,Wu, W.J.,Tsai, M.D. A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerase. Commun Chem 2024 7 45 45 8JA2 38418525 ASFV Topoisomerase ATPase domain in complex with AMP-PNP and Mg2+ 2023-05-05 2024-02-07 Chang, C.M.,Wang, S.C.,Wang, C.H.,Pang, A.H.,Yang, C.H.,Chang, Y.K.,Wu, W.J.,Tsai, M.D. A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerase. Commun Chem 2024 7 45 45 8IQ5 38349137 Crystal structure of trimeric K2-2 TSP 2023-03-15 2024-02-21 Ye, T.J.,Fung, K.M.,Lee, I.M.,Ko, T.P.,Lin, C.Y.,Wong, C.L.,Tu, I.F.,Huang, T.Y.,Yang, F.L.,Chang, Y.P.,Wang, J.T.,Lin, T.L.,Huang, K.F.,Wu, S.H. Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation. Mbio 2024 15 0 0 8K16 38719864 KtrA bound with ATP and thallium 2023-07-10 2024-04-03 Chiang, W.T.,Chang, Y.K.,Hui, W.H.,Chang, S.W.,Liao, C.Y.,Chang, Y.C.,Chen, C.J.,Wang, W.C.,Lai, C.C.,Wang, C.H.,Luo, S.Y.,Huang, Y.P.,Chou, S.H.,Horng, T.L.,Hou, M.H.,Muench, S.P.,Chen, R.S.,Tsai, M.D.,Hu, N.J. Structural basis and synergism of ATP and Na + activation in bacterial K + uptake system KtrAB. Nat Commun 2024 15 3850 3850 8K1K 38719864 KtrA bound with ATP and sodium 2023-07-11 2024-04-03 Chiang, W.T.,Chang, Y.K.,Hui, W.H.,Chang, S.W.,Liao, C.Y.,Chang, Y.C.,Chen, C.J.,Wang, W.C.,Lai, C.C.,Wang, C.H.,Luo, S.Y.,Huang, Y.P.,Chou, S.H.,Horng, T.L.,Hou, M.H.,Muench, S.P.,Chen, R.S.,Tsai, M.D.,Hu, N.J. Structural basis and synergism of ATP and Na + activation in bacterial K + uptake system KtrAB. Nat Commun 2024 15 3850 3850 8IYE Structure of VldE-D158N in complex with GDP 2023-04-04 2024-04-10 Wong, C.P.,Mori, T.,Mahmud, T.,Abe, I. Structure of VldE-D158N in complex with GDP To Be Published 0 0 0 0 8IYF Structure of VldE-H182A in complex with GDP 2023-04-04 2024-04-10 Wong, C.P.,Mori, T.,Mahmud, T.,Abe, I. Structure of VldE-H182A in complex with GDP To Be Published 0 0 0 0 8K7D 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7E 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7F 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7G 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7H 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R)-2-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7I 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2-(hydroxymethyl)-5-((methylamino)methyl)pyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7J 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-((dimethylamino)methyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7K 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)-1-methylpyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8K7L 38559739 Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol 2023-07-26 2024-04-10 Li, H.Y.,Lin, H.Y.,Chang, S.K.,Chiu, Y.T.,Hou, C.C.,Ko, T.P.,Huang, K.F.,Niu, D.M.,Cheng, W.C. Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au 2024 4 908 918 8J8Y Phytoplasma immunodominant membrane protein 2023-05-02 2024-05-08 Wang, H.C.,Ko, T.P. Phytoplasma immunodominant membrane protein To Be Published 0 0 0 0 8JBP Crystal structure of triosephosphate isomerase from Leishmania orientalis at 1.45 angstroms resolution with an arsenic atom bound at Cys57 2023-05-09 2024-05-15 Kuaprasert, B.,Leartsakulpanich, U.,Riangrungroj, P.,Pornthanakasem, W.,Suginta, W.,Robinson, C.R.,Zhou, Y.,Mungthin, M.,Leelayoova, S.,Saehlee, S.,Kiriwan, D.,Choowongkomon, K. Leishmania orientalis triosephosphate isomerase crystal structure at 1.45 angstroms resolution and its potential specific inhibitors To be published 0 0 0 0 8YD8 38710704 Structure of FADD/Caspase-8/cFLIP death effector domain assembly 2024-02-19 2024-05-15 Yang, C.Y.,Lien, C.I.,Tseng, Y.C.,Tu, Y.F.,Kulczyk, A.W.,Lu, Y.C.,Wang, Y.T.,Su, T.W.,Hsu, L.C.,Lo, Y.C.,Lin, S.C. Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nat Commun 2024 15 3791 3791 8JMJ 38842933 Structure of Helicobacter pylori Soj-DNA-Spo0J complex 2023-06-05 2024-05-29 Chu, C.H.,Wu, C.T.,Lin, M.G.,Yen, C.Y.,Wu, Y.Z.,Hsiao, C.D.,Sun, Y.J. Insights into the molecular mechanism of ParABS system in chromosome partition by HpParA and HpParB. Nucleic Acids Res. 2024 52 7321 7336 8JMK 38842933 Structure of Helicobacter pylori Soj mutant, D41A bound to DNA 2023-06-05 2024-05-29 Chu, C.H.,Wu, C.T.,Lin, M.G.,Yen, C.Y.,Wu, Y.Z.,Hsiao, C.D.,Sun, Y.J. Insights into the molecular mechanism of ParABS system in chromosome partition by HpParA and HpParB. Nucleic Acids Res. 2024 52 7321 7336 8XP8 38989613 Crystal structure of d(ACGmCCGT/ACGGCGT) in complex with Echinomycin 2024-01-03 2024-05-29 Lin, S.M.,Huang, H.T.,Fang, P.J.,Chang, C.F.,Satange, R.,Chang, C.K.,Chou, S.H.,Neidle, S.,Hou, M.H. Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation. Nucleic Acids Res. 2024 52 8566 8579 8XPA 38989613 Crystal structure of d(ACGmCCGT/ACGGCGT) 2024-01-03 2024-05-29 Lin, S.M.,Huang, H.T.,Fang, P.J.,Chang, C.F.,Satange, R.,Chang, C.K.,Chou, S.H.,Neidle, S.,Hou, M.H. Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation. Nucleic Acids Res. 2024 52 8566 8579 8XUD 38937433 Crystal structure of adaptor NlpI in complex with endopeptidase MepS and PDZ-protease Prc 2024-01-12 2024-06-05 Wang, S.,Huang, C.H.,Lin, T.S.,Yeh, Y.Q.,Fan, Y.S.,Wang, S.W.,Tseng, H.C.,Huang, S.J.,Chang, Y.Y.,Jeng, U.S.,Chang, C.I.,Tzeng, S.R. Structural basis for recruitment of peptidoglycan endopeptidase MepS by lipoprotein NlpI. Nat Commun 2024 15 5461 5461 8XUP 38937433 Crystal structure of lipoprotein NlpI in complex with MepS 2024-01-13 2024-06-05 Wang, S.,Huang, C.H.,Lin, T.S.,Yeh, Y.Q.,Fan, Y.S.,Wang, S.W.,Tseng, H.C.,Huang, S.J.,Chang, Y.Y.,Jeng, U.S.,Chang, C.I.,Tzeng, S.R. Structural basis for recruitment of peptidoglycan endopeptidase MepS by lipoprotein NlpI. Nat Commun 2024 15 5461 5461 8JUQ Crystal structure of Chitoporin from Vibrio harveyi in complex with gentamicin c1a 2023-06-27 2024-07-03 Sanram, S.,Suginta, W. Crystal structure of Chitoporin from Vibrio harveyi in complex with gentamicin c1a To Be Published 0 0 0 0 8JUR Crystal structure of Chitoporin from Vibrio harveyi in complex with gentamicin c1a (multiple binding sites) 2023-06-27 2024-07-03 Sanram, S.,Suginta, W. Crystal structure of Chitoporin from Vibrio harveyi in complex with gentamicin c1a (multiple binding sites) To Be Published 0 0 0 0 8W4G 38938812 Crystal structure of EndoSz mutant D234M, from Streptococcus equi subsp. Zooepidemicus Sz105 2023-08-24 2024-07-03 Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au 2024 4 2130 2150 8W4I 38938812 Crystal structure of EndoSz mutant D234M in space group P21 2023-08-24 2024-07-03 Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au 2024 4 2130 2150 8W4L 38938812 Crystal structure of closed conformation of human immunoglobulin Fc in presence of EndoSz 2023-08-24 2024-07-03 Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au 2024 4 2130 2150 8W4M 38938812 Crystal structure of open conformation of human immunoglobulin Fc in presence of EndoSz 2023-08-24 2024-07-03 Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au 2024 4 2130 2150 8W4N 38938812 Crystal structure of EndoSz mutant D234M, in space group P21, in complex with oligosaccharide G2S1 2023-08-24 2024-07-03 Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au 2024 4 2130 2150 8X8G 38938812 Crystal structure of EndoSz mutant D234M, from Streptococcus equi subsp. Zooepidemicus Sz105, in complex with oligosaccharide G2S2-oxazoline 2023-11-27 2024-07-03 Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J. Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism. Jacs Au 2024 4 2130 2150 8JZ6 Crystal structure of AetF in complex with FAD and NADP+ at 2.66 angstrom 2023-07-04 2024-07-10 Li, H.,Dai, L.,Chen, C.-C.,Guo, R.-T. Crystal structure of AetF in complex with FAD and NADP+ at 2.66 angstrom To Be Published 0 0 0 0 8K32 The complex structure of SLKARI with NADH at 2.12-angstrom resolution 2023-07-14 2024-07-17 Chen, C.Y.,Huang, C.H. Structural bases of coenzyme specificity of thermophilic ketol-acid reductoisomerase To Be Published 0 0 0 0 8WQN 39077943 Structure of Saccharolobus solfataricus SegC (SSO0033) protein 2023-10-12 2024-08-07 Lin, M.G.,Yen, C.Y.,Shen, Y.Y.,Huang, Y.S.,Ng, I.W.,Barilla, D.,Sun, Y.J.,Hsiao, C.D. Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea. Nucleic Acids Res. 2024 52 9966 9977 8YK9 39077943 Structure of Saccharolobus solfataricus SegC (SSO0033) protein, ATP soak 2024-03-04 2024-08-07 Lin, M.G.,Yen, C.Y.,Shen, Y.Y.,Huang, Y.S.,Ng, I.W.,Barilla, D.,Sun, Y.J.,Hsiao, C.D. Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea. Nucleic Acids Res. 2024 52 9966 9977 9C1W 39506119 Structure of AKT2 with compound 3 2024-05-29 2024-09-04 Craven, G.B.,Chu, H.,Sun, J.D.,Carelli, J.D.,Coyne, B.,Chen, H.,Chen, Y.,Ma, X.,Das, S.,Kong, W.,Zajdlik, A.D.,Yang, K.S.,Reisberg, S.H.,Thompson, P.A.,Lipford, J.R.,Taunton, J. Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation. Nature 2025 637 205 214 8Z4Q 39227380 The crystal structure of a Hydroquinone Dioxygenase PaD 2024-04-17 2024-09-11 Cui, C.,Yang, L.J.,Liu, Z.W.,Shu, X.,Zhang, W.W.,Gao, Y.,Wang, Y.X.,Wang, T.,Chen, C.C.,Guo, R.T.,Gao, S.S. Substrate specificity of a branch of aromatic dioxygenases determined by three distinct motifs. Nat Commun 2024 15 7682 7682 8Z4R 39227380 The crystal structure of a Hydroquinone Dioxygenase PaD with substrate 2024-04-17 2024-09-11 Cui, C.,Yang, L.J.,Liu, Z.W.,Shu, X.,Zhang, W.W.,Gao, Y.,Wang, Y.X.,Wang, T.,Chen, C.C.,Guo, R.T.,Gao, S.S. Substrate specificity of a branch of aromatic dioxygenases determined by three distinct motifs. Nat Commun 2024 15 7682 7682 8Z4S 39227380 The crystal structure of a Hydroquinone Dioxygenase PaD with nonnatural substrate S6 2024-04-17 2024-09-11 Cui, C.,Yang, L.J.,Liu, Z.W.,Shu, X.,Zhang, W.W.,Gao, Y.,Wang, Y.X.,Wang, T.,Chen, C.C.,Guo, R.T.,Gao, S.S. Substrate specificity of a branch of aromatic dioxygenases determined by three distinct motifs. Nat Commun 2024 15 7682 7682 9JUE Roadblock3 homodimer structure from Candidatus Prometheoarchaeum syntrophicum strain MK-D1 2024-10-08 2024-10-16 Ponlachantra, K.,Robinson, R.C. Roadblock domain protein from Asgard archaea To Be Published 0 0 0 0 9JQ8 Roadblock2 homodimer structure from Candidatus Prometheoarchaeum syntrophicum strain MK-D1 2024-09-27 2024-10-30 Ponlachantra, K.,Robinson, R.C. Roadblock domain protein from Asgard archaea To Be Published 0 0 0 0 8XZY 39082219 Structure of a xylanase Xyl-1 M4 mutant E175A 2024-01-21 2024-11-27 Wu, Y.,Yang, Y.,Lu, G.,Xiang, W.L.,Sun, T.Y.,Chen, K.W.,Lv, X.,Gui, Y.F.,Zeng, R.Q.,Du, Y.K.,Fu, C.H.,Huang, J.W.,Chen, C.C.,Guo, R.T.,Yu, L.J. Unleashing the Power of Evolution in Xylanase Engineering: Investigating the Role of Distal Mutation Regulation. J.Agric.Food Chem. 2024 72 18201 18213 8XZZ 39082219 Structure of a xylanase Xyl-1 M4 E175A in complex with xylobiose 2024-01-21 2024-11-27 Wu, Y.,Yang, Y.,Lu, G.,Xiang, W.L.,Sun, T.Y.,Chen, K.W.,Lv, X.,Gui, Y.F.,Zeng, R.Q.,Du, Y.K.,Fu, C.H.,Huang, J.W.,Chen, C.C.,Guo, R.T.,Yu, L.J. Unleashing the Power of Evolution in Xylanase Engineering: Investigating the Role of Distal Mutation Regulation. J.Agric.Food Chem. 2024 72 18201 18213 8Y00 39082219 Structure of a xylanase Xyl-1 M4 mutant E175A in complex with xylotriose 2024-01-21 2024-11-27 Wu, Y.,Yang, Y.,Lu, G.,Xiang, W.L.,Sun, T.Y.,Chen, K.W.,Lv, X.,Gui, Y.F.,Zeng, R.Q.,Du, Y.K.,Fu, C.H.,Huang, J.W.,Chen, C.C.,Guo, R.T.,Yu, L.J. Unleashing the Power of Evolution in Xylanase Engineering: Investigating the Role of Distal Mutation Regulation. J.Agric.Food Chem. 2024 72 18201 18213 8XAO 38867953 The thermostable and acid-tolerant DNA-binding protein 2023-12-05 2024-12-11 Tang, S.,Huang, C.H.,Ko, T.P.,Lin, K.F.,Chang, Y.C.,Lin, P.Y.,Sun, L.,Chen, C.Y. Dual dimeric interactions in the nucleic acid-binding protein Sac10b lead to multiple bridging of double-stranded DNA. Heliyon 2024 10 0 0 8XAP 38867953 Thermostable and acid-tolerant DNA-binding protein 2023-12-05 2024-12-11 Tang, S.,Huang, C.H.,Ko, T.P.,Lin, K.F.,Chang, Y.C.,Lin, P.Y.,Sun, L.,Chen, C.Y. Dual dimeric interactions in the nucleic acid-binding protein Sac10b lead to multiple bridging of double-stranded DNA. Heliyon 2024 10 0 0 8XAQ 38867953 The thermostable and acid-tolerant DNA-binding protein 2023-12-05 2024-12-11 Tang, S.,Huang, C.H.,Ko, T.P.,Lin, K.F.,Chang, Y.C.,Lin, P.Y.,Sun, L.,Chen, C.Y. Dual dimeric interactions in the nucleic acid-binding protein Sac10b lead to multiple bridging of double-stranded DNA. Heliyon 2024 10 0 0 8ZAC 39747870 Crystal structure of BcABA3 from Botrytis cinerea 2024-04-25 2024-12-11 Li, S.,Huang, J.W.,Min, J.,Li, H.,Ning, M.,Zhou, S.,Yang, Y.,Chen, C.C.,Guo, R.T. Molecular insights into a distinct class of terpenoid cyclases. Nat Commun 2025 16 207 207 8ZAF 39747870 Crystal structure of SkABA3 from Shimazuella kribbensis 2024-04-25 2024-12-11 Li, S.,Huang, J.W.,Min, J.,Li, H.,Ning, M.,Zhou, S.,Yang, Y.,Chen, C.C.,Guo, R.T. Molecular insights into a distinct class of terpenoid cyclases. Nat Commun 2025 16 207 207 8ZAG 39747870 Crystal structure of SkABA3 from Shimazuella kribbensis in complex with PPi 2024-04-25 2024-12-11 Li, S.,Huang, J.W.,Min, J.,Li, H.,Ning, M.,Zhou, S.,Yang, Y.,Chen, C.C.,Guo, R.T. Molecular insights into a distinct class of terpenoid cyclases. Nat Commun 2025 16 207 207 8XUA Oligogalacturonate-specific porin from Vibrio harveyi (VhGalP) 2024-01-12 2024-12-25 Meesrikaew, P.,Sanram, S.,Robinson, R.,Suginta, W. Oligogalacturonate-specific porin from Vibrio harveyi (VhGalP) To be published 0 0 0 0 8Z7K 39761280 Crystal structure of Hemolysin co-regulated protein 1 (Hcp1) VariantB from Burkholderia pseudomallei 2024-04-20 2024-12-25 Tandhavanant, S.,Yimthin, T.,Sengyee, S.,Charoenwattanasatien, R.,Lebedev, A.A.,Lafontaine, E.R.,Hogan, R.J.,Chewapreecha, C.,West, T.E.,Brett, P.J.,Burtnick, M.N.,Chantratita, N. Genetic variation of hemolysin co-regulated protein 1 affects the immunogenicity and pathogenicity of Burkholderia pseudomallei. Plos Negl Trop Dis 2025 19 0 0 8YEV 39481728 Dual-specificity tyrosine phosphorylation-regulated kinase 1A in complex with coumestrol 2024-02-23 2025-01-01 Peng, C.H.,Hwang, T.L.,Hung, S.C.,Tu, H.J.,Tseng, Y.T.,Lin, T.E.,Lee, C.C.,Tseng, Y.C.,Ko, C.Y.,Yen, S.C.,Hsu, K.C.,Pan, S.L.,HuangFu, W.C. Identification, biological evaluation, and crystallographic analysis of coumestrol as a novel dual-specificity tyrosine-phosphorylation-regulated kinase 1A inhibitor. Int.J.Biol.Macromol. 2024 282 136860 136860 8Z2T 39109746 Crystal structure of trehalose synthase from Deinococcus radiodurans complexed with validoxylamine A (VAA) 2024-04-13 2025-01-01 Ye, L.C.,Chow, S.Y.,Chang, S.C.,Kuo, C.H.,Wang, Y.L.,Wei, Y.J.,Lee, G.C.,Liaw, S.H.,Chen, W.M.,Chen, S.C. Structural and Mutational Analyses of Trehalose Synthase from Deinococcus radiodurans Reveal the Interconversion of Maltose-Trehalose Mechanism. J.Agric.Food Chem. 2024 72 18649 18657 8Z2U 39109746 Crystal structure of trehalose synthase mutamt E324D from Deinococcus radiodurans complexed with validoxylamine A (VAA) 2024-04-13 2025-01-01 Ye, L.C.,Chow, S.Y.,Chang, S.C.,Kuo, C.H.,Wang, Y.L.,Wei, Y.J.,Lee, G.C.,Liaw, S.H.,Chen, W.M.,Chen, S.C. Structural and Mutational Analyses of Trehalose Synthase from Deinococcus radiodurans Reveal the Interconversion of Maltose-Trehalose Mechanism. J.Agric.Food Chem. 2024 72 18649 18657 9ISR 39591507 Human MTHFD1 in complex with compound 16g 2024-07-18 2025-01-01 Chang, H.H.,Lee, L.C.,Hsu, T.,Peng, Y.H.,Huang, C.H.,Yeh, T.K.,Lu, C.T.,Huang, Z.T.,Hsueh, C.C.,Kung, F.C.,Lin, L.M.,Huang, Y.C.,Wang, Y.H.,Li, L.H.,Tang, Y.C.,Chang, L.,Hsieh, C.C.,Jiaang, W.T.,Kuo, C.C.,Wu, S.Y. Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization. J.Med.Chem. 2024 67 21106 21125 9ITD 39591507 Human MTHFD1 in complex with compound 16a 2024-07-19 2025-01-01 Chang, H.H.,Lee, L.C.,Hsu, T.,Peng, Y.H.,Huang, C.H.,Yeh, T.K.,Lu, C.T.,Huang, Z.T.,Hsueh, C.C.,Kung, F.C.,Lin, L.M.,Huang, Y.C.,Wang, Y.H.,Li, L.H.,Tang, Y.C.,Chang, L.,Hsieh, C.C.,Jiaang, W.T.,Kuo, C.C.,Wu, S.Y. Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization. J.Med.Chem. 2024 67 21106 21125 9IUO 39591507 Human MTHFD1 in complex with compound 16d 2024-07-22 2025-01-01 Chang, H.H.,Lee, L.C.,Hsu, T.,Peng, Y.H.,Huang, C.H.,Yeh, T.K.,Lu, C.T.,Huang, Z.T.,Hsueh, C.C.,Kung, F.C.,Lin, L.M.,Huang, Y.C.,Wang, Y.H.,Li, L.H.,Tang, Y.C.,Chang, L.,Hsieh, C.C.,Jiaang, W.T.,Kuo, C.C.,Wu, S.Y. Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization. J.Med.Chem. 2024 67 21106 21125 8XWO Vibrio harveyi chitoporin in complex with minocycline 2024-01-16 2025-01-22 Sanram, S.,Suginta, W.,Robinson, R.C. VhChiP in complex with minocycline To Be Published 0 0 0 0 8YSC 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with ATP (form 1) 2024-03-22 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSD 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with ATP (form 2) 2024-03-22 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSE 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with dATP 2024-03-22 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSG 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with GTP 2024-03-22 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSI 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with UTP 2024-03-23 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSJ 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with UMPNPP 2024-03-23 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSL 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with UTP and ATP 2024-03-23 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSR 39761885 Crystal structure of the Deinococcus wulumuqiensis CD-NTase DwCdnB in complex with hexatungstotellurate(VI) TEW 2024-03-23 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 8YSS 39761885 Crystal structure of the apo form of Deinococcus wulumuqiensis CD-NTase DwCdnB 2024-03-23 2025-01-29 Yang, C.S.,Shie, M.Y.,Huang, S.W.,Wang, Y.C.,Hou, M.H.,Chen, C.J.,Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int.J.Biol.Macromol. 2025 295 139534 139534 9JN4 Crystal structure of KtzT-C197A in complex with HEME 2024-09-22 2025-01-29 Yang, Y.,Li, Y.,Yao, L.,Dai, K.,Fu, X.,Ge, A.,Huang, J.W.,Guo, R.T.,Chen, C.C. Structural Insights into the N-N Bond-Formation Mechanism of the Heme-Dependent Piperazate Synthase KtzT Acs Catalysis 2025 15 1265 1273 9JN5 Crystal structure of KtzT-C197A in complex with HEME and substrate 2024-09-22 2025-01-29 Yang, Y.,Li, Y.,Yao, L.,Dai, K.,Fu, X.,Ge, A.,Huang, J.W.,Guo, R.T.,Chen, C.C. Structural Insights into the N-N Bond-Formation Mechanism of the Heme-Dependent Piperazate Synthase KtzT Acs Catalysis 2025 15 1265 1273 9JN6 Crystal structure of KtzT-C197A in complex with HEME and product 2024-09-22 2025-01-29 Yang, Y.,Li, Y.,Yao, L.,Dai, K.,Fu, X.,Ge, A.,Huang, J.W.,Guo, R.T.,Chen, C.C. Structural Insights into the N-N Bond-Formation Mechanism of the Heme-Dependent Piperazate Synthase KtzT Acs Catalysis 2025 15 1265 1273 8YQH 38968608 Crystal structure of Cry3Aa-PEI at 3.1 A 2024-03-19 2025-02-12 Yekta, R.,Xiong, X.,Li, J.,Heater, B.S.,Lee, M.M.,Chan, M.K. Mechanoresponsive Protein Crystals for NADH Recycling in Multicycle Enzyme Reactions. J.Am.Chem.Soc. 2024 146 18817 18822 8YFP Chito oligosaccharide deacetylase from vibrio campbellii (VhCOD) 2024-02-25 2025-02-26 Sirikan, P.,Wipa, S.,Tamo, F.,Robinson, R.C. Structural and functional of Chito oligosaccharide deacetylase of Vibrio cambellii To be published 0 0 0 0 8YFP Chito oligosaccharide deacetylase from vibrio campbellii (VhCOD) 2024-02-25 2025-02-26 Sirikan, P.,Wipa, S.,Tamo, F.,Robinson, R.C. Structural and functional of Chito oligosaccharide deacetylase of Vibrio cambellii To be published 0 0 0 0 8YH4 Chito oligosaccharide deacetylase from vibrio campbellii (VhCOD) in complex with chitosanbiose (GlcN)2 2024-02-27 2025-03-05 Sirikan, P.,Wipa, S.,Tamo, F.,Robinson, R.C. Chito oligosaccharide deacetylase from vibrio campbellii (VhCOD) in complex with chitosanbiose (GlcN)2 To be published 0 0 0 0 8YH4 Chito oligosaccharide deacetylase from vibrio campbellii (VhCOD) in complex with chitosanbiose (GlcN)2 2024-02-27 2025-03-05 Sirikan, P.,Wipa, S.,Tamo, F.,Robinson, R.C. Chito oligosaccharide deacetylase from vibrio campbellii (VhCOD) in complex with chitosanbiose (GlcN)2 To be published 0 0 0 0 8YNX 39032488 Crystal structure of Cag3-CagT complex from Helicobacter pylori 2024-03-12 2025-03-19 Mok, C.Y.,Chu, H.Y.,Lam, W.W.L.,Au, S.W.N. Structural insights into the assembly pathway of the Helicobacter pylori CagT4SS outer membrane core complex. Structure 2024 32 1725 0 8YQG Dimeric structure of the Longin domain from a Lokiarchaeota archaeon Roadblock-Longin protein 2024-03-19 2025-03-26 Sitthisak, P.,Kitaoku, Y.,Robinson, R.C. Structure of the Longin domain from a Lokiarchaeota archaeon Roadblock-Longin protein To Be Published 0 0 0 0 8YS7 Crystal structure of actinomycin D and Echinomycin-d(ACGGGCT/AGCCCCGT) complex 2024-03-22 2025-04-09 Lee, Y.Y.,Hou, M.H. Crystal structure of actinomycin D and Echinomycin-d(ACGGGCT/AGCCCCGT) complex To Be Published 0 0 0 0 8ZX2 40130308 Structure-Based Mechanism and Specificity of Human Galactosyltransferase B3GalT5 2024-06-13 2025-04-09 Lo, J.M.,Kung, C.C.,Cheng, T.R.,Wong, C.H.,Ma, C. Structure-Based Mechanism and Specificity of Human Galactosyltransferase beta 3GalT5. J.Am.Chem.Soc. 2025 147 10875 10885 8ZX3 40130308 Structure-Based Mechanism and Specificity of Human Galactosyltransferase B3GalT5 2024-06-13 2025-04-09 Lo, J.M.,Kung, C.C.,Cheng, T.R.,Wong, C.H.,Ma, C. Structure-Based Mechanism and Specificity of Human Galactosyltransferase beta 3GalT5. J.Am.Chem.Soc. 2025 147 10875 10885 9HNL 40298610 Structure of the (6-4) photolyase of Caulobacter crescentus in its oxidized state at room temperture-synchrotron 2024-12-11 2025-05-07 Wang, P.H.,Hosokawa, Y.,C Soares, J.,Emmerich, H.J.,Fuchs, V.,Caramello, N.,Engilberge, S.,Bologna, A.,Rosner, C.J.,Nakamura, M.,Watad, M.,Luo, F.,Owada, S.,Tosha, T.,Kang, J.,Tono, K.,Bessho, Y.,Nango, E.,Pierik, A.J.,Royant, A.,Tsai, M.D.,Yamamoto, J.,Maestre-Reyna, M.,Essen, L.O. Redox-State-Dependent Structural Changes within a Prokaryotic 6-4 Photolyase. J.Am.Chem.Soc. 2025 147 16084 16098 9DF3 40465424 EGFR Exon20 insertion mutant SVD bound with (S)-3-((3-chloro-2-methoxyphenyl)amino)-2-(3-((tetrahydrofuran-2-yl)methoxy)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one 2024-08-29 2025-05-14 Pagliarini, R.A.,Henderson, J.A.,Milgram, B.C.,Borrelli, D.R.,Brooijmans, N.,Hilbert, B.J.,Huff, M.R.,Ito, T.,Kryukov, G.V.,Ladd, B.,Martin, B.R.,Motiwala, H.,O'Hearn, E.,Tsai, C.F.,Wang, W.,Bellier, J.,Boland, L.,Clark, S.,Hensley, E.,Hata, A.N.,Kuzmic, P.,Guzman-Perez, A.,Jackson, E.L.,Stuart, D.D. STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models. Clin.Cancer Res. 2025 0 0 0 9L5U 40424468 Papain-like cysteine protease toxin/immunity pair 2024-12-23 2025-06-04 Song, P.Y.,Tsai, C.E.,Chen, Y.C.,Huang, Y.W.,Chen, P.P.,Wang, T.H.,Hu, C.Y.,Chen, P.Y.,Ku, C.,Hsia, K.C.,Ting, S.Y. An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE. Plos Biol. 2025 23 0 0 8ZXI Peptide channel interactions in the truncated VhChiP nanopore 2024-06-14 2025-06-18 Sanram, S.,Suginta, W.,Robinson, R.C. Structure and function of truncated VhChiP To Be Published 0 0 0 0 9UPT Structure of AtBgl1A, a GH1 beta-Glucosidase from Acetivibrio thermocellus 2025-04-29 2025-07-02 Pitchayatanakorn, P.,Putthasang, P.,Chomngam, S.,Jongkon, N.,Choowongkomon, K.,Kongsaeree, P.,Fushinobu, S.,Kongsaeree, P.T. Structure-Based Engineering to Improve Thermostability of Acetivibrio thermocellus AtBgl1A beta-Glucosidase Acs Omega 2025 0 0 0 9KUQ 40513738 Crystal structure of a C45 isoprenyl diphosphate synthase, Rv0562 from Mycobacterium tuberculosis 2024-12-04 2025-07-09 Wang, Q.,Yang, Y.,He, B.,Huang, J.W.,Kuo, C.J.,Chen, C.C.,Guo, R.T. Structural insight of a bi-functional isoprenyl diphosphate synthase Rv0562 from Mycobacterium tuberculosis. Int.J.Biol.Macromol. 2025 0 145171 145171