PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 3ID4 19706448 Crystal Structure of RseP PDZ2 domain fused GKASPV peptide 2009-07-20 2009-08-11 Li, X.,Wang, B.,Feng, L.,Kang, H.,Qi, Y.,Wang, J.,Shi, Y. Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage Proc.Natl.Acad.Sci.USA 2009 106 14837 14842 3I6D 19944166 Crystal structure of PPO from bacillus subtilis with AF 2009-07-06 2009-12-08 Qin, X.,Sun, L.,Wen, X.,Yang, X.,Tan, Y.,Jin, H.,Cao, Q.,Zhou, W.,Xi, Z.,Shen, Y. Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis J.Struct.Biol. 2010 170 76 82 3K3N 20101266 Crystal structure of the catalytic core domain of human PHF8 2009-10-03 2010-01-19 Yu, L.,Wang, Y.,Huang, S.,Wang, J.,Deng, Z.,Zhang, Q.,Wu, W.,Zhang, X.,Liu, Z.,Gong, W.,Chen, Z. Structural insights into a novel histone demethylase PHF8 Cell Res. 2010 20 166 173 3K3O 20101266 Crystal structure of the catalytic core domain of human PHF8 complexed with alpha-ketoglutarate 2009-10-03 2010-01-19 Yu, L.,Wang, Y.,Huang, S.,Wang, J.,Deng, Z.,Zhang, Q.,Wu, W.,Zhang, X.,Liu, Z.,Gong, W.,Chen, Z. Structural insights into a novel histone demethylase PHF8 Cell Res. 2010 20 166 173 3IU3 20032294 Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain 2009-08-29 2010-01-26 Du, J.,Yang, H.,Zhang, D.,Wang, J.,Guo, H.,Peng, B.,Guo, Y.,Ding, J. Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab J.Immunol. 2010 184 1361 1368 3KYS 20123905 Crystal structure of human YAP and TEAD complex 2009-12-07 2010-02-23 Li, Z.,Zhao, B.,Wang, P.,Chen, F.,Dong, Z.,Yang, H.,Guan, K.L.,Xu, Y. Structural insights into the YAP and TEAD complex Genes Dev. 2010 24 235 240 3L9Y 20310068 Crystal structures of holo and Cu-deficient Cu/ZnSOD from the silkworm Bombyx mori and the implications in Amyotrophic lateral sclerosis 2010-01-06 2010-03-23 Zhang, N.N.,He, Y.X.,Li, W.F.,Teng, Y.B.,Yu, J.,Chen, Y.,Zhou, C.Z. Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis. Proteins 2010 78 1999 2004 3LQQ 20434985 Structure of the CED-4 Apoptosome 2010-02-09 2010-04-28 Qi, S.,Pang, Y.,Hu, Q.,Liu, Q.,Li, H.,Zhou, Y.,He, T.,Liang, Q.,Liu, Y.,Yuan, X.,Luo, G.,Li, H.,Wang, J.,Yan, N.,Shi, Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell(Cambridge,Mass.) 2010 141 446 457 3LWH 20345658 Crystal structure of Cren7-dsDNA complex 2010-02-23 2010-05-26 Zhang, Z.F.,Gong, Y.,Guo, L.,Jiang, T.,Huang, L. Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA Mol.Microbiol. 2010 76 749 759 3LWI 20345658 Crystal structure of Cren7-dsDNA complex 2010-02-23 2010-05-26 Zhang, Z.F.,Gong, Y.,Guo, L.,Jiang, T.,Huang, L. Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA Mol.Microbiol. 2010 76 749 759 3KXT 20512977 Crystal structure of Sulfolobus Cren7-dsDNA complex 2009-12-03 2010-06-09 Feng, Y.,Yao, H.,Wang, J. Crystal structure of the crenarchaeal conserved chromatin protein Cren7 and double-stranded DNA complex Protein Sci. 2010 19 1253 1257 3NEG 20554531 Pyrabactin-bound PYL1 structure in the open and close forms 2010-06-08 2010-06-16 Hao, Q.,Yin, P.,Yan, C.,Yuan, X.,Li, W.,Zhang, Z.,Liu, L.,Wang, J.,Yan, N. Functional mechanism of the ABA agonist pyrabactin J.Biol.Chem. 2010 285 28946 28952 3I19 1.4 Angstrom Crystal Structure of Fluorescent Protein Cypet 2009-06-25 2010-06-30 Liu, R.,Ding, Y.,Hu, X. 1.4 Angstrom Crystal Structure of Fluorescent Protein Cypet To be Published 0 0 0 0 3N9L 20567261 ceKDM7A from C.elegans, complex with H3K4me3 peptide and NOG 2010-05-31 2010-06-30 Yang, Y.,Hu, L.,Wang, P.,Hou, H.,Lin, Y.,Liu, Y.,Li, Z.,Gong, R.,Feng, X.,Zhou, L.,Zhang, W.,Dong, Y.,Yang, H.,Lin, H.,Wang, Y.,Chen, C.D.,Xu, Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res. 2010 20 886 898 3N9N 20567261 ceKDM7A from C.elegans, complex with H3K4me3K9me2 peptide and NOG 2010-05-31 2010-06-30 Yang, Y.,Hu, L.,Wang, P.,Hou, H.,Lin, Y.,Liu, Y.,Li, Z.,Gong, R.,Feng, X.,Zhou, L.,Zhang, W.,Dong, Y.,Yang, H.,Lin, H.,Wang, Y.,Chen, C.D.,Xu, Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res. 2010 20 886 898 3N9O 20567261 ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K9me2 peptide and NOG 2010-05-31 2010-06-30 Yang, Y.,Hu, L.,Wang, P.,Hou, H.,Lin, Y.,Liu, Y.,Li, Z.,Gong, R.,Feng, X.,Zhou, L.,Zhang, W.,Dong, Y.,Yang, H.,Lin, H.,Wang, Y.,Chen, C.D.,Xu, Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res. 2010 20 886 898 3N9P 20567261 ceKDM7A from C.elegans, complex with H3K4me3K27me2 peptide and NOG 2010-05-31 2010-06-30 Yang, Y.,Hu, L.,Wang, P.,Hou, H.,Lin, Y.,Liu, Y.,Li, Z.,Gong, R.,Feng, X.,Zhou, L.,Zhang, W.,Dong, Y.,Yang, H.,Lin, H.,Wang, Y.,Chen, C.D.,Xu, Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res. 2010 20 886 898 3N9Q 20567261 ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K27me2 peptide and NOG 2010-05-31 2010-06-30 Yang, Y.,Hu, L.,Wang, P.,Hou, H.,Lin, Y.,Liu, Y.,Li, Z.,Gong, R.,Feng, X.,Zhou, L.,Zhang, W.,Dong, Y.,Yang, H.,Lin, H.,Wang, Y.,Chen, C.D.,Xu, Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res. 2010 20 886 898 3NK6 20550164 Structure of the Nosiheptide-resistance methyltransferase 2010-06-18 2010-07-21 Yang, H.,Wang, Z.,Shen, Y.,Wang, P.,Jia, X.,Zhao, L.,Zhou, P.,Gong, R.,Li, Z.,Yang, Y.,Chen, D.,Murchie, A.I.H.,Xu, Y. Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus Biochemistry 2010 49 6440 6450 3NK7 20550164 Structure of the Nosiheptide-resistance methyltransferase S-adenosyl-L-methionine Complex 2010-06-18 2010-07-21 Yang, H.,Wang, Z.,Shen, Y.,Wang, P.,Jia, X.,Zhao, L.,Zhou, P.,Gong, R.,Li, Z.,Yang, Y.,Chen, D.,Murchie, A.I.H.,Xu, Y. Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus Biochemistry 2010 49 6440 6450 3NS2 20630864 High-resolution structure of pyrabactin-bound PYL2 2010-07-01 2010-07-21 Yuan, X.,Yin, P.,Hao, Q.,Yan, C.,Wang, J.,Yan, N. Single amino acid alteration between Valine and Isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2 J.Biol.Chem. 2010 285 28953 28958 3NGN 20628353 Crystal structure of the human CNOT6L nuclease domain in complex with AMP 2010-06-12 2010-07-28 Wang, H.,Morita, M.,Yang, X.,Suzuki, T.,Yang, W.,Wang, J.,Ito, K.,Wang, Q.,Zhao, C.,Bartlam, M.,Yamamoto, T.,Rao, Z. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. Embo J. 2010 0 0 0 3NGO 20628353 Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA 2010-06-12 2010-07-28 Wang, H.,Morita, M.,Yang, X.,Suzuki, T.,Yang, W.,Wang, J.,Ito, K.,Wang, Q.,Zhao, C.,Bartlam, M.,Yamamoto, T.,Rao, Z. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. Embo J. 2010 0 0 0 3AL4 21203961 Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus 2010-07-22 2010-08-04 Zhang, W.,Qi, J.,Shi, Y.,Li, Q.,Gao, F.,Sun, Y.,Lu, X.,Lu, Q.,Vavricka, C.J.,Liu, D.,Yan, J.,Gao, G.F. Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus Protein Cell 2010 1 459 467 3N9T Cryatal structure of Hydroxyquinol 1,2-dioxygenase from Pseudomonas putida DLL-E4 2010-05-31 2010-08-04 Liu, W.,Shen, W.,Fang, P.,Li, J.,Cui, Z. Cryatal structure of Hydroxyquinol 1,2-dioxygenase from Pseudomonas putida DLL-E4 To be Published 0 0 0 0 3LA7 20616047 Crystal structure of NtcA in apo-form 2010-01-06 2010-09-01 Zhao, M.X.,Jiang, Y.L.,He, Y.X.,Chen, Y.F.,Teng, Y.B.,Chen, Y.X.,Zhang, C.C.,Zhou, C.Z. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc.Natl.Acad.Sci.USA 2010 107 12487 12492 3N5B 20708625 The complex of PII and PipX from Anabaena 2010-05-24 2010-09-01 Zhao, M.-X.,Jiang, Y.-L.,Xu, B.-Y.,Chen, Y.-X.,Zhang, C.-C.,Zhou, C.-Z. Crystal structure of the cyanobacterial signal transduction protein PII in complex with PipX. J.Mol.Biol. 2010 402 552 559 3O4O 20802483 Crystal structure of an Interleukin-1 receptor complex 2010-07-27 2010-09-01 Wang, D.L.,Zhang, S.Y.,Li, L.,Liu, X.,Mei, K.R.,Wang, X.Q. Structural insights into the assembly and activation of IL-1beta with its receptors Nat.Immunol. 2010 11 905 911 3MNM 20704189 Crystal structure of GAE domain of GGA2p from Saccharomyces cerevisiae 2010-04-21 2010-09-08 Fang, P.,Li, X.,Wang, J.,Niu, L.,Teng, M. Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5 Biochemistry 2010 49 7949 7955 3NI2 20841425 Crystal structures and enzymatic mechanisms of a Populus tomentosa 4-coumarate:CoA ligase 2010-06-14 2010-09-08 Hu, Y.,Gai, Y.,Yin, L.,Wang, X.,Feng, C.,Feng, L.,Li, D.,Jiang, X.N.,Wang, D.C. Crystal structures of a Populus tomentosa 4-coumarate:CoA ligase shed light on its enzymatic mechanisms Plant Cell 2010 22 3093 3104 3NFP 20820193 Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain 2010-06-10 2010-09-15 Yang, H.,Wang, J.,Du, J.,Zhong, C.,Zhang, D.,Guo, H.,Guo, Y.,Ding, J. Structural basis of immunosuppression by the therapeutic antibody daclizumab Cell Res. 2010 20 1361 1371 3NTH 20713507 Crystal structure of Tudor and Aubergine [R13(me2s)] complex 2010-07-05 2010-09-15 Liu, H.P.,Wang, J.Y.,Huang, Y.,Li, Z.Z.,Gong, W.M.,Lehmann, R.,Xu, R.M. Structural basis for methylarginine-dependent recognition of Aubergine by Tudor Genes Dev. 2010 24 1876 1881 3NTI 20713507 Crystal structure of Tudor and Aubergine [R15(me2s)] complex 2010-07-05 2010-09-15 Liu, H.P.,Wang, J.Y.,Huang, Y.,Li, Z.Z.,Gong, W.M.,Lehmann, R.,Xu, R.M. Structural basis for methylarginine-dependent recognition of Aubergine by Tudor Genes Dev. 2010 24 1876 1881 3O7P 20877283 Crystal structure of the E.coli Fucose:proton symporter, FucP (N162A) 2010-07-30 2010-09-15 Dang, S.Y.,Sun, L.F.,Huang, Y.,Lu, F.,Liu, Y.,Gong, H.,Wang, J.,Yan, N. Structure of a fucose transporter in an outward-open conformation Nature 2010 467 734 738 3NSS 20852645 The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active sites 2010-07-02 2010-09-22 Li, Q.,Qi, J.X.,Zhang, W.,Vavricka, C.J.,Shi, Y.,Wei, J.H.,Feng, E.G.,Shen, J.S.,Chen, J.L.,Liu, D.,He, J.H.,Yan, J.H.,Liu, H.,Jiang, H.L.,Teng, M.K.,Li, X.B.,Gao, G.F. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site Nat.Struct.Mol.Biol. 2010 17 1266 1268 3N2Y 20919707 Crystal structure of tyrosyl-tRNA synthetase complexed with p-(2-tetrazolyl)-phenylalanine 2010-05-19 2010-11-03 Wang, J.,Zhang, W.,Song, W.,Wang, Y.,Yu, Z.,Li, J.,Wu, M.,Wang, L.,Zang, J.,Lin, Q. A biosynthetic route to photoclick chemistry on proteins J.Am.Chem.Soc. 2010 132 14812 14818 3P6Y CF Im25-CF Im68-UGUAA complex 2010-10-11 2010-11-03 Li, H.,Tong, S.,Li, X.,Shi, H.,Gao, Y.,Ge, H.,Niu, L.,Teng, M. Structural basis of pre-mRNA recognition by the human cleavage factor Im complex To be Published 0 0 0 0 3MAP 20975740 Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate 2010-03-24 2010-11-10 Yang, B.,Zhong, C.,Peng, Y.,Lai, Z.,Ding, J. Molecular mechanisms of ""off-on switch"" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res. 2010 20 1188 1200 3MAS 20975740 Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate 2010-03-24 2010-11-10 Yang, B.,Zhong, C.,Peng, Y.,Lai, Z.,Ding, J. Molecular mechanisms of ""off-on switch"" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res. 2010 20 1188 1200 3NSM 21106526 Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 from Ostrinia furnacalis 2010-07-02 2010-11-24 Liu, T.,Zhang, H.,Liu, F.,Wu, Q.,Shen, X.,Yang, Q. Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme J.Biol.Chem. 2011 286 4049 4058 3NSN 21106526 Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with TMG-chitotriomycin 2010-07-02 2010-11-24 Liu, T.,Zhang, H.,Liu, F.,Wu, Q.,Shen, X.,Yang, Q. Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme J.Biol.Chem. 2011 286 4049 4058 3O05 20919991 Crystal Structure of Yeast Pyridoxal 5-Phosphate Synthase Snz1 Complxed with Substrate PLP 2010-07-19 2010-11-24 Zhang, X.,Teng, Y.B.,Liu, J.P.,He, Y.X.,Zhou, K.,Chen, Y.,Zhou, C.Z. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1 Biochem.J. 2010 432 445 450 3O06 20919991 Crystal Structure of yeast pyridoxal 5-phosphate synthase Snz1 2010-07-19 2010-11-24 Zhang, X.,Teng, Y.B.,Liu, J.P.,He, Y.X.,Zhou, K.,Chen, Y.,Zhou, C.Z. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1 Biochem.J. 2010 432 445 450 3O07 20919991 Crystal structure of yeast pyridoxal 5-phosphate synthase Snz1 complexed with substrate G3P 2010-07-19 2010-11-24 Zhang, X.,Teng, Y.B.,Liu, J.P.,He, Y.X.,Zhou, K.,Chen, Y.,Zhou, C.Z. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1 Biochem.J. 2010 432 445 450 3OFS 21134381 Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography 2010-08-16 2010-12-15 Zhang, H.,Graeff, R.,Chen, Z.,Zhang, L.R.,Zhang, L.H.,Lee, H.C.,Hao, Q. Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal J.Mol.Biol. 2011 405 1070 1078 3NO7 21123191 Crystal structure of the centromere-binding protein ParB from plasmid pCXC100 2010-06-24 2010-12-22 Huang, L.,Yin, P.,Zhu, X.,Zhang, Y.,Ye, K. Crystal structure and centromere binding of the plasmid segregation protein ParB from pCXC100 Nucleic Acids Res. 2011 39 2954 2968 3OOI 21196496 Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine 2010-08-31 2010-12-22 Qiao, Q.,Li, Y.,Chen, Z.,Wang, M.,Reinberg, D.,Xu, R.M. The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation J.Biol.Chem. 2010 286 8361 8368 3OPT 21067515 Crystal structure of the Rph1 catalytic core with a-ketoglutarate 2010-09-02 2010-12-22 Chang, Y.,Wu, J.,Tong, X.J.,Zhou, J.Q.,Ding, J. Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism Biochem.J. 2011 433 295 302 3OPW 21067515 Crystal Structure of the Rph1 catalytic core 2010-09-02 2010-12-22 Chang, Y.,Wu, J.,Tong, X.J.,Zhou, J.Q.,Ding, J. Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism Biochem.J. 2011 433 295 302 3PB1 21199867 Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator 2010-10-20 2010-12-29 Lin, Z.,Jiang, L.,Yuan, C.,Jensen, J.K.,Zhang, X.,Luo, Z.,Furie, B.C.,Furie, B.,Andreasen, P.A.,Huang, M. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J.Biol.Chem. 2011 286 7027 7032 3PZ8 Crystal structure of Dvl1-DIX(Y17D) mutant 2010-12-14 2010-12-29 Liu, Y.T.,Dan, Q.J.,Wang, J.W.,Feng, Y.G.,Chen, L.,Liang, J.,Li, Q.X.,Lin, S.C.,Wang, Z.X.,Wu, J.W. Molecular basis of WNT activation via the DIX-domain protein CCD1 To be Published 0 0 0 0 3L9C The Crystal Structure of smu.777 from Streptococcus mutans UA159 2010-01-05 2011-01-05 Su, X.-D.,Huang, Y.H.,Liu, X. The Crystal Structure of smu.777 from Streptococcus mutans UA159 TO BE PUBLISHED 0 0 0 0 3LA1 High resolution crystal structure of CyPet mutant A167I 2010-01-06 2011-01-12 Hu, X.,Liu, R. Crystal Structure of CyPet To be Published 0 0 0 0 3LAS Crystal structure of carbonic anhydrase from streptococcus mutans to 1.4 angstrom resolution 2010-01-07 2011-01-12 Ma, L.-L.,Wang, K.-T.,Liu, X.,Su, X.-D. Crystal structure of carbonic anhydrase from streptococcus mutans to 1.4 angstrom resolution To be published 0 0 0 0 3PLA 21270896 Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus 2010-11-15 2011-01-26 Lin, J.,Lai, S.,Jia, R.,Xu, A.,Zhang, L.,Lu, J.,Ye, K. Structural basis for site-specific ribose methylation by box C/D RNA protein complexes. Nature 2011 469 559 563 3PUQ 21251613 CEKDM7A from C.Elegans, complex with alpha-KG 2010-12-06 2011-01-26 Xu, W.,Yang, H.,Liu, Y.,Yang, Y.,Wang, P.,Kim, S.-H.,Ito, S.,Yang, C.,Wang, P.,Xiao, M.-T.,Liu, L.-X.,Jiang, W.-Q.,Liu, J.,Zhang, J.-Y.,Wang, B.,Frye, S.,Zhang, Y.,Xu, Y.-H.,Lei, Q.-Y.,Guan, K.-L.,Zhao, S.-M.,Xiong, Y. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases Cancer Cell 2011 19 17 30 3PUR 21251613 CEKDM7A from C.Elegans, complex with D-2-HG 2010-12-06 2011-01-26 Xu, W.,Yang, H.,Liu, Y.,Yang, Y.,Wang, P.,Kim, S.-H.,Ito, S.,Yang, C.,Wang, P.,Xiao, M.-T.,Liu, L.-X.,Jiang, W.-Q.,Liu, J.,Zhang, J.-Y.,Wang, B.,Frye, S.,Zhang, Y.,Xu, Y.-H.,Lei, Q.-Y.,Guan, K.-L.,Zhao, S.-M.,Xiong, Y. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases Cancer Cell 2011 19 17 30 3OZJ 21262235 Crystal structure of human retinoic X receptor alpha complexed with bigelovin and coactivator SRC-1 2010-09-25 2011-02-02 Zhang, H.,Li, L.,Chen, L.,Hu, L.,Jiang, H.,Shen, X. Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode J.Mol.Biol. 2011 407 13 20 3PL9 21297637 Crystal structure of spinach minor light-harvesting complex CP29 at 2.80 angstrom resolution 2010-11-14 2011-02-09 Pan, X.,Li, M.,Wan, T.,Wang, L.,Jia, C.,Hou, Z.,Zhao, X.,Zhang, J.,Chang, W. Structural insights into energy regulation of light-harvesting complex CP29 from spinach. Nat.Struct.Mol.Biol. 2011 18 309 315 3Q48 21304995 Crystal structure of Pseudomonas aeruginosa CupB2 chaperone 2010-12-23 2011-02-09 Cai, X.,Wang, R.,Filloux, A.,Waksman, G.,Meng, G. Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones Plos One 2011 6 0 0 3OXF 21266482 Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form I) 2010-09-21 2011-02-23 Xu, S.,Wu, J.,Sun, B.,Zhong, C.,Ding, J. Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res. 2011 39 4438 4449 3OXG 21266482 human lysine methyltransferase Smyd3 in complex with AdoHcy (Form III) 2010-09-21 2011-02-23 Xu, S.,Wu, J.,Sun, B.,Zhong, C.,Ding, J. Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res. 2011 39 4438 4449 3OXL 21266482 Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form II) 2010-09-21 2011-02-23 Xu, S.,Wu, J.,Sun, B.,Zhong, C.,Ding, J. Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding Nucleic Acids Res. 2011 39 4438 4449 3PIM 21345799 Crystal structure of Mxr1 from Saccharomyces cerevisiae in unusual oxidized form 2010-11-07 2011-02-23 Ma, X.X.,Guo, P.C.,Shi, W.W.,Luo, M.,Tan, X.F.,Chen, Y.,Zhou, C.Z. Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1 J.Biol.Chem. 2011 286 13430 13437 3PIN 21345799 Crystal structure of Mxr1 from Saccharomyces cerevisiae in complex with Trx2 2010-11-07 2011-02-23 Ma, X.X.,Guo, P.C.,Shi, W.W.,Luo, M.,Tan, X.F.,Chen, Y.,Zhou, C.Z. Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1 J.Biol.Chem. 2011 286 13430 13437 3OPX Crystal structure of pyrimidine 5 -nucleotidase SDT1 from Saccharomyces cerevisiae complexed with uridine 5'-monophosphate 2010-09-02 2011-03-02 Shi, N.,Teng, M.K.,Niu, L.W. Crystal structure of pyrimidine 5 -nucleotidase SDT1 from Saccharomyces cerevisiae complexed with uridine 5'-monophosphate To be published 0 0 0 0 3PVL 21311020 Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans 2010-12-07 2011-03-02 Wu, L.,Pan, L.,Wei, Z.,Zhang, M. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science 2011 331 757 760 3QNU 21368113 Crystal structure of the cytosolic domain of human atlastin-1 in complex with GDP, hexagonal form 2011-02-09 2011-03-02 Bian, X.,Klemm, R.W.,Liu, T.Y.,Zhang, M.,Sun, S.,Sui, X.,Liu, X.,Rapoport, T.A.,Hu, J. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc.Natl.Acad.Sci.USA 2011 108 3976 3981 3QOF 21368113 Crystal structure of the cytosolic domain of human atlastin-1 in complex with GDP, orthorhombic form 2011-02-09 2011-03-02 Bian, X.,Klemm, R.W.,Liu, T.Y.,Zhang, M.,Sun, S.,Sui, X.,Liu, X.,Rapoport, T.A.,Hu, J. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc.Natl.Acad.Sci.USA 2011 108 3976 3981 3OVP 20923965 Crystal Structure of hRPE 2010-09-16 2011-03-09 Liang, W.G.,Ouyang, S.Y.,Shaw, N.,Joachimiak, A.,Zhang, R.G.,Liu, Z.J. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE Faseb J. 2011 25 497 504 3M3W 22573331 Crystal structure of mouse PACSIN3 BAR domain mutant 2010-03-10 2011-03-16 Bai, X.Y.,Meng, G.,Luo, M.,Zheng, X.F. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules J.Biol.Chem. 2012 287 22387 22396 3O72 21324904 Crystal structure of EfeB in complex with heme 2010-07-30 2011-03-16 Liu, X.,Du, Q.,Wang, Z.,Zhu, D.,Huang, Y.,Li, N.,Wei, T.,Xu, S.,Gu, L. Crystal structure and biochemical features of EfeB/YcdB from Escherichia coli O157: ASP235 plays divergent roles in different enzyme-catalyzed processes J.Biol.Chem. 2011 286 14922 14931 3Q47 21454478 Crystal structure of TPR domain of CHIP complexed with pseudophosphorylated Smad1 peptide 2010-12-23 2011-03-16 Wang, L.,Liu, Y.T.,Hao, R.,Chen, L.,Chang, Z.,Wang, H.R.,Wang, Z.X.,Wu, J.W. Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP). J.Biol.Chem. 2011 286 15883 15894 3Q49 21454478 Crystal structure of the TPR domain of CHIP complexed with Hsp70-C peptide 2010-12-23 2011-03-16 Wang, L.,Liu, Y.T.,Hao, R.,Chen, L.,Chang, Z.,Wang, H.R.,Wang, Z.X.,Wu, J.W. Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP). J.Biol.Chem. 2011 286 15883 15894 3Q4A 21454478 Crystal structure of the TPR domain of CHIP complexed with phosphorylated Smad1 peptide 2010-12-23 2011-03-16 Wang, L.,Liu, Y.T.,Hao, R.,Chen, L.,Chang, Z.,Wang, H.R.,Wang, Z.X.,Wu, J.W. Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP). J.Biol.Chem. 2011 286 15883 15894 3OF7 21093592 The Crystal Structure of Prp20p from Saccharomyces cerevisiae and Its Binding Properties to Gsp1p and Histones 2010-08-14 2011-03-23 Wu, F.,Liu, Y.,Zhu, Z.,Huang, H.,Ding, B.,Wu, J.,Shi, Y. The 1.9A crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones. J.Struct.Biol. 2011 174 213 222 3OLC 20858457 Crystal structure of the N-terminal region of TopBP1 2010-08-25 2011-03-30 Huo, Y.G.,Bai, L.,Xu, M.,Jiang, T. Crystal structure of the N-terminal region of human Topoisomerase II beta binding protein 1 Biochem.Biophys.Res.Commun. 2010 401 401 405 3R45 21478274 Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP 2011-03-17 2011-04-06 Hu, H.,Liu, Y.,Wang, M.,Fang, J.,Huang, H.,Yang, N.,Li, Y.,Wang, J.,Yao, X.,Shi, Y.,Li, G.,Xu, R.M. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP Genes Dev. 2011 25 901 906 3N3Z Crystal structure of PDE9A (E406A) mutant in complex with IBMX 2010-05-21 2011-04-13 Hou, J.,Luo, H.-B.,Chen, Y.,Xu, J.,Zhao, R.,Zou, L. Crystal structure of PDE9A (E406A) mutation in complex with IBMX To be Published 0 0 0 0 3OLE 21111049 Structures of human pancreatic alpha-amylase in complex with acarviostatin II03 2010-08-26 2011-04-13 Qin, X.,Ren, L.,Yang, X.,Bai, F.,Wang, L.,Geng, P.,Bai, G.,Shen, Y. Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes. J.Struct.Biol. 2011 174 196 202 3OLI 21111049 Structures of human pancreatic alpha-amylase in complex with acarviostatin IV03 2010-08-26 2011-04-13 Qin, X.,Ren, L.,Yang, X.,Bai, F.,Wang, L.,Geng, P.,Bai, G.,Shen, Y. Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes. J.Struct.Biol. 2011 174 196 202 3QQ2 21306302 Crystal Structure of the Beta Domain of the Bordetella Autotransporter Brka 2011-02-14 2011-04-13 Zhai, Y.,Zhang, K.,Huo, Y.,Zhu, Y.,Zhou, Q.,Lu, J.,Black, I.,Pang, X.,Roszak, A.W.,Zhang, X.,Isaacs, N.W.,Sun, F. Autotransporter passenger domain secretion requires a hydrophobic cavity at the extracellular entrance of the beta-domain pore Biochem.J. 2011 435 577 587 3AJF 21460234 Structural insigths into dsRNA binding and RNA silencing suppression by NS3 protein of rice hoja blanca tenuivirus 2010-06-05 2011-04-20 Yang, X.,Tan, S.H.,Teh, Y.J.,Yuan, Y.A. Structural implications into dsRNA binding and RNA silencing suppression by NS3 protein of Rice Hoja Blanca Tenuivirus Rna 2011 17 903 911 3AXJ High resolution crystal structure of C3PO 2011-04-07 2011-04-20 Yuan, Y.A.,Yang, X. High resolution crystal structure of C3PO To be Published 0 0 0 0 3NKS 21048046 Structure of human protoporphyrinogen IX oxidase 2010-06-21 2011-04-20 Qin, X.,Tan, Y.,Wang, L.,Wang, Z.,Wang, B.,Wen, X.,Yang, G.,Xi, Z.,Shen, Y. Structural insight into human variegate porphyria disease Faseb J. 2011 25 653 664 3RAJ Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7 2011-03-28 2011-04-27 Zhang, H.,Zhao, Y.J.,Hao, Q.,Lee, H.C. Engineering a novel cytosolic form of CD38 for cyclic ADP-ribose dependent signaling To be Published 0 0 0 0 3MP1 21685874 Complex structure of Sgf29 and trimethylated H3K4 2010-04-24 2011-05-04 Bian, C.,Xu, C.,Ruan, J.,Lee, K.K.,Burke, T.L.,Tempel, W.,Barsyte, D.,Li, J.,Wu, M.,Zhou, B.O.,Fleharty, B.E.,Paulson, A.,Allali-Hassani, A.,Zhou, J.Q.,Mer, G.,Grant, P.A.,Workman, J.L.,Zang, J.,Min, J. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J. 2011 30 2829 2842 3MP6 21685874 Complex Structure of Sgf29 and dimethylated H3K4 2010-04-25 2011-05-04 Bian, C.,Xu, C.,Ruan, J.,Lee, K.K.,Burke, T.L.,Tempel, W.,Barsyte, D.,Li, J.,Wu, M.,Zhou, B.O.,Fleharty, B.E.,Paulson, A.,Allali-Hassani, A.,Zhou, J.Q.,Mer, G.,Grant, P.A.,Workman, J.L.,Zang, J.,Min, J. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J. 2011 30 2829 2842 3MP8 21685874 Crystal structure of Sgf29 tudor domain 2010-04-26 2011-05-04 Bian, C.,Xu, C.,Ruan, J.,Lee, K.K.,Burke, T.L.,Tempel, W.,Barsyte, D.,Li, J.,Wu, M.,Zhou, B.O.,Fleharty, B.E.,Paulson, A.,Allali-Hassani, A.,Zhou, J.Q.,Mer, G.,Grant, P.A.,Workman, J.L.,Zang, J.,Min, J. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Embo J. 2011 30 2829 2842 3PPV 21385852 Crystal structure of an engineered VWF A2 domain (N1493C and C1670S) 2010-11-25 2011-05-04 Zhou, M.,Dong, X.,Baldauf, C.,Chen, H.,Zhou, Y.,Springer, T.A.,Luo, X.,Zhong, C.,Grater, F.,Ding, J. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood 2011 117 4623 4631 3PPW 21385852 Crystal structure of the D1596A mutant of an engineered VWF A2 domain (N1493C and C1670S) 2010-11-25 2011-05-04 Zhou, M.,Dong, X.,Baldauf, C.,Chen, H.,Zhou, Y.,Springer, T.A.,Luo, X.,Zhong, C.,Grater, F.,Ding, J. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood 2011 117 4623 4631 3PPX 21385852 Crystal structure of the N1602A mutant of an engineered VWF A2 domain (N1493C and C1670S) 2010-11-25 2011-05-04 Zhou, M.,Dong, X.,Baldauf, C.,Chen, H.,Zhou, Y.,Springer, T.A.,Luo, X.,Zhong, C.,Grater, F.,Ding, J. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood 2011 117 4623 4631 3PPY 21385852 Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S) 2010-11-25 2011-05-04 Zhou, M.,Dong, X.,Baldauf, C.,Chen, H.,Zhou, Y.,Springer, T.A.,Luo, X.,Zhong, C.,Grater, F.,Ding, J. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13 Blood 2011 117 4623 4631 3QFL 21402358 Coiled-Coil Domain-Dependent Homodimerization of Intracellular MLA Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death 2011-01-21 2011-05-04 Maekawa, T.,Cheng, W.,Spiridon, L.N.,Toller, A.,Lukasik, E.,Saijo, Y.,Liu, P.,Shen, Q.H.,Micluta, M.A.,Somssich, I.E.,Takken, F.L.,Petrescu, A.J.,Chai, J.,Schulze-Lefert, P. Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death Cell Host Microbe 2011 9 187 199 3RNV Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase 2011-04-22 2011-05-04 Guo, B.,Lin, J.,Ye, K. Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase to be published 0 0 0 0 3PPN 21366542 Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC 2010-11-24 2011-05-11 Du, Y.,Shi, W.W.,He, Y.X.,Yang, Y.H.,Zhou, C.Z.,Chen, Y. Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC Biochem.J. 2011 436 283 289 3PPQ 21366542 Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC 2010-11-25 2011-05-11 Du, Y.,Shi, W.W.,He, Y.X.,Yang, Y.H.,Zhou, C.Z.,Chen, Y. Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC Biochem.J. 2011 436 283 289 3PPR 21366542 Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC 2010-11-25 2011-05-11 Du, Y.,Shi, W.W.,He, Y.X.,Yang, Y.H.,Zhou, C.Z.,Chen, Y. Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of the Bacillus subtilis ABC transporter OpuC Biochem.J. 2011 436 283 289 3NDQ Structure of Human TFIIS Domain II 2010-06-07 2011-05-18 Ye, X.,Gnatt, A.,Hu, X.P. Structure of Human TFIIS Domain II To be Published 0 0 0 0 3N3Y Crystal structure of Thymidylate Synthase X (ThyX) from Helicobacter pylori with FAD and dUMP at 2.31A resolution 2010-05-21 2011-05-25 Wang, K.,Wang, Q.,Chen, J.,Chen, L.,Jiang, H.,Shen, X. Structure, Enzymatic Characterization and Inhibitor Discovery of Thymidylate Synthase X (ThyX) from Helicobacter pylori Strain SS1 To be Published 0 0 0 0 3N3Y Crystal structure of Thymidylate Synthase X (ThyX) from Helicobacter pylori with FAD and dUMP at 2.31A resolution 2010-05-21 2011-05-25 Wang, K.,Wang, Q.,Chen, J.,Chen, L.,Jiang, H.,Shen, X. Structure, Enzymatic Characterization and Inhibitor Discovery of Thymidylate Synthase X (ThyX) from Helicobacter pylori Strain SS1 To be Published 0 0 0 0 3P12 21276853 Crystal Structure of D-ribose Pyranase Sa240 2010-09-29 2011-05-25 Wang, L.,Wu, M.,Zang, J. Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus J.Struct.Biol. 2011 174 413 419 3P13 21276853 Complex Structure of D-ribose Pyranase Sa240 with D-ribose 2010-09-29 2011-05-25 Wang, L.,Wu, M.,Zang, J. Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus J.Struct.Biol. 2011 174 413 419 3QOW 21564555 DOT1L Structure in complex with SAM 2011-02-11 2011-05-25 Richon, V.M.,Johnston, D.,Sneeringer, C.J.,Jin, L.,Majer, C.R.,Elliston, K.,Jerva, L.F.,Scott, M.P.,Copeland, R.A. Chemogenetic analysis of human protein methyltransferases. Chem.Biol.Drug Des. 2011 78 199 210 3QOX 21564555 DOT1L structure in complex with SAH 2011-02-11 2011-05-25 Richon, V.M.,Johnston, D.,Sneeringer, C.J.,Jin, L.,Majer, C.R.,Elliston, K.,Jerva, L.F.,Scott, M.P.,Copeland, R.A. Chemogenetic analysis of human protein methyltransferases. Chem.Biol.Drug Des. 2011 78 199 210 3R29 21613212 Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 2011-03-14 2011-05-25 Zhang, H.,Chen, L.,Chen, J.,Jiang, H.,Shen, X. Structural basis for retinoic x receptor repression on the tetramer. J.Biol.Chem. 2011 286 24593 24598 3R2A 21613212 Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein 2011-03-14 2011-05-25 Zhang, H.,Chen, L.,Chen, J.,Jiang, H.,Shen, X. Structural basis for retinoic x receptor repression on the tetramer. J.Biol.Chem. 2011 286 24593 24598 3PUB 21514389 Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7) 2010-12-03 2011-06-01 Yang, J.-P.,Ma, X.-X.,He, Y.-X.,Li, W.-F.,Kang, Y.,Bao, R.,Chen, Y.,Zhou, C.-Z. Crystal structure of the 30 K protein from the silkworm Bombyx mori reveals a new member of the beta-trefoil superfamily J.Struct.Biol. 2011 175 97 103 3QIC 21420961 The structure of human glucokinase E339K mutation 2011-01-27 2011-06-01 Liu, Q.,Shen, Y.,Liu, S.,Weng, J.,Liu, J. Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site. Febs Lett. 2011 585 1175 1179 3QUW 21600990 Crystal structure of yeast Mmf1 2011-02-24 2011-06-08 Pu, Y.G.,Jiang, Y.L.,Ye, X.D.,Ma, X.X.,Guo, P.C.,Lian, F.M.,Teng, Y.B.,Chen, Y.,Zhou, C.Z. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. J.Struct.Biol. 2011 175 469 474 3QV0 21600990 Crystal structure of Saccharomyces cerevisiae Mam33 2011-02-24 2011-06-08 Pu, Y.G.,Jiang, Y.L.,Ye, X.D.,Ma, X.X.,Guo, P.C.,Lian, F.M.,Teng, Y.B.,Chen, Y.,Zhou, C.Z. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. J.Struct.Biol. 2011 175 469 474 3N6L 21203964 The crystal structure of RNA-dependent RNA polymerase of EV71 virus 2010-05-26 2011-06-15 Wu, Y.,Lou, Z.,Miao, Y.,Yu, Y.,Dong, H.,Peng, W.,Bartlam, M.,Li, X.,Rao, Z. Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell 2010 1 491 500 3NFC Crystal structure of E.coli MazF Toxin 2010-06-10 2011-06-15 Wang, X.,Wang, K.,Gao, X.,Zhang, X.,Li, L.,Su, X.,Zhang, J. Biochemical and Structural Analysis of E. coli MazF Toxin To be Published 0 0 0 0 3O71 21070949 Crystal structure of ERK2/DCC peptide complex 2010-07-30 2011-06-15 Ma, W.,Shang, Y.,Wei, Z.,Wen, W.,Wang, W.,Zhang, M. Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase Structure 2010 18 1502 1511 3RGX 21666666 Structural insight into brassinosteroid perception by BRI1 2011-04-11 2011-06-15 She, J.,Han, Z.,Kim, T.W.,Wang, J.,Cheng, W.,Chang, J.,Shi, S.,Wang, J.,Yang, M.,Wang, Z.Y.,Chai, J. Structural insight into brassinosteroid perception by BRI1. Nature 2011 474 472 476 3RGZ 21666666 Structural insight into brassinosteroid perception by BRI1 2011-04-11 2011-06-15 She, J.,Han, Z.,Kim, T.W.,Wang, J.,Cheng, W.,Chang, J.,Shi, S.,Wang, J.,Yang, M.,Wang, Z.Y.,Chai, J. Structural insight into brassinosteroid perception by BRI1. Nature 2011 474 472 476 3QD7 21276852 Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli 2011-01-18 2011-06-22 Gui, W.J.,Qu, Q.H.,Chen, Y.Y.,Wang, M.,Zhang, X.E.,Bi, L.J.,Jiang, T. Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli. J.Struct.Biol. 2011 174 282 289 3RE1 21527255 Crystal structure of uroporphyrinogen III synthase from Pseudomonas syringae pv. tomato DC3000 2011-04-02 2011-06-22 Peng, S.X.,Zhang, H.,Gao, Y.,Pan, X.,Cao, P.,Li, M.,Chang, W.R. Crystal structure of uroporphyrinogen III synthase from Pseudomonas syringae pv. tomato DC3000 Biochem.Biophys.Res.Commun. 2011 408 576 581 3NMW 21788986 Crystal structure of armadillo repeats domain of APC 2010-06-22 2011-07-06 Zhang, Z.,Chen, L.,Gao, L.,Lin, K.,Zhu, L.,Lu, Y.,Shi, X.,Gao, Y.,Zhou, J.,Xu, P.,Zhang, J.,Wu, G. Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res. 2012 22 372 386 3NMX 21788986 Crystal structure of APC complexed with Asef 2010-06-22 2011-07-06 Zhang, Z.,Chen, L.,Gao, L.,Lin, K.,Zhu, L.,Lu, Y.,Shi, X.,Gao, Y.,Zhou, J.,Xu, P.,Zhang, J.,Wu, G. Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res. 2012 22 372 386 3P2M 21637775 Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis 2010-10-03 2011-07-06 Zheng, X.D.,Guo, J.,Xu, L.,Li, H.,Zhang, D.,Zhang, K.,Sun, F.,Wen, T.,Liu, S.,Pang, H. Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis Plos One 2011 6 0 0 3QAH 21691301 Crystal structure of apo-form human MOF catalytic domain 2011-01-11 2011-07-06 Sun, B.,Guo, S.,Tang, Q.,Li, C.,Zeng, R.,Xiong, Z.,Zhong, C.,Ding, J. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274 Cell Res. 2011 21 1262 1266 3RPN 21728995 Crystal structure of human kappa class glutathione transferase in complex with S-hexylglutathione 2011-04-27 2011-07-13 Wang, B.,Peng, Y.,Zhang, T.,Ding, J. Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism. Biochem.J. 2011 439 215 225 3RPP 21728995 Crystal structure of human kappa class glutathione transferase in apo form 2011-04-27 2011-07-13 Wang, B.,Peng, Y.,Zhang, T.,Ding, J. Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism. Biochem.J. 2011 439 215 225 3RT3 Complex of influenza virus protein with host anti-viral factor 2011-05-03 2011-07-13 Li, L.,Wang, X.Q. Crystal structure of human ISG15 in complex with influenza B virus NS1B To be Published 0 0 0 0 3ONJ 21746902 Crystal structure of yeast Vti1p_Habc domain 2010-08-29 2011-07-20 Wang, J.,Gossing, M.,Fang, P.,Zimmermann, J.,Li, X.,von Mollard, G.F.,Niu, L.,Teng, M. Epsin N-terminal homology domains bind on opposite sides of two SNAREs Proc.Natl.Acad.Sci.USA 2011 108 12277 12282 3ONL 21746902 yeast Ent3_ENTH-Vti1p_Habc complex structure 2010-08-29 2011-07-20 Wang, J.,Gossing, M.,Fang, P.,Zimmermann, J.,Li, X.,von Mollard, G.F.,Niu, L.,Teng, M. Epsin N-terminal homology domains bind on opposite sides of two SNAREs Proc.Natl.Acad.Sci.USA 2011 108 12277 12282 3RIB 21724641 Human lysine methyltransferase Smyd2 in complex with AdoHcy 2011-04-13 2011-07-20 Xu, S.,Zhong, C.,Zhang, T.,Ding, J. Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins J Mol Cell Biol 2011 3 293 300 3Q7J 21493078 Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development 2011-01-05 2011-07-27 Su, J.,Wang, Q.,Feng, J.,Zhang, C.,Zhu, D.,Wei, T.,Xu, W.,Gu, L. Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development Bioorg.Med.Chem. 2011 19 2991 2996 3OY5 21802428 The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4 2010-09-22 2011-08-10 Jiang, L.G.,Svane, A.S.P.,Sorensen, H.P.,Jensen, J.K.,Hosseini, M.,Chen, Z.,Weydert, C.,Nielsen, J.T.,Christensen, A.,Yuan, C.,Jensen, K.J.,Nielsen, N.C.,Malmendal, A.,Huang, M.D.,Andreasen, P.A. The binding mechanism of a peptidic cyclic serine protease inhibitor J.Mol.Biol. 2011 412 235 250 3OY6 21802428 The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6 2010-09-22 2011-08-10 Jiang, L.G.,Svane, A.S.P.,Sorensen, H.P.,Jensen, J.K.,Hosseini, M.,Chen, Z.,Weydert, C.,Nielsen, J.T.,Christensen, A.,Yuan, C.,Jensen, K.J.,Nielsen, N.C.,Malmendal, A.,Huang, M.D.,Andreasen, P.A. The binding mechanism of a peptidic cyclic serine protease inhibitor J.Mol.Biol. 2011 412 235 250 3Q6B 21795783 The high-resolution and new form crystal structure of BamA POTRA4-5 from E.coli 2010-12-31 2011-08-10 Zhang, H.,Gao, Z.Q.,Hou, H.F.,Xu, J.H.,Li, L.F.,Su, X.D.,Dong, Y.H. High-resolution structure of a new crystal form of BamA POTRA4-5 from Escherichia coli. Acta Crystallogr.,Sect.F 2011 67 734 738 3QNI Crystal structure of human PACSIN 1 F-BAR domain 2011-02-08 2011-08-10 Meng, G.,Bai, X.,Zheng, X. Crystal structure of human PACSIN 1 F-BAR domain to be published 0 0 0 0 3RBT 21816159 Crystal structure of glutathione S-transferase Omega 3 from the silkworm Bombyx mori 2011-03-29 2011-08-10 Chen, B.-Y.,Ma, X.-X.,Guo, P.-C.,Tan, X.,Li, W.-F.,Yang, J.-P.,Zhang, N.-N.,Chen, Y.,Xia, Q.,Zhou, C.-Z. Structure-guided activity restoration of the silkworm glutathione transferase Omega GSTO3-3 J.Mol.Biol. 2011 412 204 211 3SIP 21811237 Crystal structure of drICE and dIAP1-BIR1 complex 2011-06-20 2011-08-10 Li, X.,Wang, J.,Shi, Y. Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. Nat Commun 2011 2 408 408 3ON9 21829356 The SECRET domain from Ectromelia virus 2010-08-28 2011-08-17 Xue, X.G.,Lu, Q.Y.,Wei, H.,Wang, D.L.,Chen, D.W.,He, G.J.,Huang, L.,Wang, H.Z.,Wang, X.Q. Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor Plos Pathog. 2011 7 0 0 3ONA 21829356 The SECRET domain in complex with CX3CL1 2010-08-28 2011-08-17 Xue, X.G.,Lu, Q.Y.,Wei, H.,Wang, D.L.,Chen, D.W.,He, G.J.,Huang, L.,Wang, H.Z.,Wang, X.Q. Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor Plos Pathog. 2011 7 0 0 3OZP 21692744 Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with PUGNAc 2010-09-27 2011-08-17 Liu, T.,Zhang, H.,Liu, F.,Chen, L.,Shen, X.,Yang, Q. Active-pocket size differentiating insectile from bacterial chitinolytic beta-N-acetyl-D-hexosaminidases Biochem.J. 2011 438 467 474 3PZ0 21819379 The crystal structure of AaLeuRS-CP1 2010-12-13 2011-08-24 Liu, R.J.,Tan, M.,Du, D.H.,Xu, B.S.,Eriani, G.,Wang, E.D. Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase Biochem.J. 2011 440 217 227 3PZ5 21819379 The crystal structure of AaLeuRS-CP1-D20 2010-12-14 2011-08-24 Liu, R.J.,Tan, M.,Du, D.H.,Xu, B.S.,Eriani, G.,Wang, E.D. Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase Biochem.J. 2011 440 217 227 3PZ6 21819379 The crystal structure of GlLeuRS-CP1 2010-12-14 2011-08-24 Liu, R.J.,Tan, M.,Du, D.H.,Xu, B.S.,Eriani, G.,Wang, E.D. Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase Biochem.J. 2011 440 217 227 3QFM Crystal structure of Streptococcal asymmetric Ap4A hydrolase and phosphodiesterase Spr1479/SapH 2011-01-22 2011-08-24 Jiang, Y.L.,Zhang, J.W.,Yu, W.L.,Cheng, W.,Zhang, C.C.,Frolet, C.,Di-guilmi, A.-M.,Vernet, T.,Zhou, C.Z.,Chen, Y. Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH To be Published 0 0 0 0 3QFN Crystal structure of Streptococcal asymmetric Ap4A hydrolase and phosphodiesterase Spr1479/SapH in complex with inorganic phosphate 2011-01-22 2011-08-24 Jiang, Y.L.,Zhang, J.W.,Yu, W.L.,Cheng, W.,Zhang, C.C.,Frolet, C.,Di-guilmi, A.-M.,Vernet, T.,Zhou, C.Z.,Chen, Y. Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH To be Published 0 0 0 0 3QFO Crystal structure of Streptococcal asymmetric Ap4A hydrolase and phosphodiesterase Spr1479/SapH im complex with AMP 2011-01-22 2011-08-24 Jiang, Y.L.,Zhang, J.W.,Yu, W.L.,Cheng, W.,Zhang, C.C.,Frolet, C.,Di-guilmi, A.-M.,Vernet, T.,Zhou, C.Z.,Chen, Y. Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH To be Published 0 0 0 0 3R7W 21816923 Crystal Structure of Gtr1p-Gtr2p complex 2011-03-23 2011-08-24 Gong, R.,Li, L.,Liu, Y.,Wang, P.,Yang, H.,Wang, L.,Cheng, J.,Guan, K.L.,Xu, Y. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation Genes Dev. 2011 25 1668 1673 3SHB 21808300 Crystal Structure of PHD Domain of UHRF1 2011-06-16 2011-08-24 Hu, L.,Li, Z.,Wang, P.,Lin, Y.,Xu, Y. Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2. Cell Res. 2011 0 0 0 3SHY 21714539 Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 2011-06-17 2011-08-24 Xu, Z.,Liu, Z.,Chen, T.,Chen, T.T.,Wang, Z.,Tian, G.,Shi, J.,Wang, X.,Lu, Y.,Yan, X.,Wang, G.,Jiang, H.,Chen, K.,Wang, S.,Xu, Y.,Shen, J.,Zhu, W. Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem. 2011 54 5607 5611 3SHZ 21714539 Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 2011-06-17 2011-08-24 Xu, Z.,Liu, Z.,Chen, T.,Chen, T.T.,Wang, Z.,Tian, G.,Shi, J.,Wang, X.,Lu, Y.,Yan, X.,Wang, G.,Jiang, H.,Chen, K.,Wang, S.,Xu, Y.,Shen, J.,Zhu, W. Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem. 2011 54 5607 5611 3SIE 21714539 Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 2011-06-17 2011-08-24 Xu, Z.,Liu, Z.,Chen, T.,Chen, T.T.,Wang, Z.,Tian, G.,Shi, J.,Wang, X.,Lu, Y.,Yan, X.,Wang, G.,Jiang, H.,Chen, K.,Wang, S.,Xu, Y.,Shen, J.,Zhu, W. Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem. 2011 54 5607 5611 3SYJ 21841773 Crystal structure of the Haemophilus influenzae Hap adhesin 2011-07-18 2011-08-24 Meng, G.,Spahich, N.,Kenjale, R.,Waksman, G.,St Geme III, J.W. Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation Embo J. 2011 30 3864 3874 3OLJ Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) 2010-08-26 2011-08-31 Chen, X.H.,Xu, Z.J.,Chen, B.E.,Jiang, H.J.,Yang, C.G.,Zhu, W.L.,Shao, J.M. hRRM2 To be Published 0 0 0 0 3TG4 21880715 Structure of SMYD2 in complex with SAM 2011-08-17 2011-08-31 Wang, L.,Li, L.,Zhang, H.,Luo, X.,Dai, J.,Zhou, S.,Gu, J.,Zhu, J.,Atadja, P.,Lu, C.,Li, E.,Zhao, K. Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem. 2011 0 0 0 3TG5 21880715 Structure of SMYD2 in complex with p53 and SAH 2011-08-17 2011-08-31 Wang, L.,Li, L.,Zhang, H.,Luo, X.,Dai, J.,Zhou, S.,Gu, J.,Zhu, J.,Atadja, P.,Lu, C.,Li, E.,Zhao, K. Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem. 2011 0 0 0 3ST9 21900233 Crystal structure of ClpP in heptameric form from Staphylococcus aureus 2011-07-09 2011-09-07 Zhang, J.,Ye, F.,Lan, L.,Jiang, H.,Luo, C.,Yang, C.-G. Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics J.Biol.Chem. 2011 286 37590 37601 3STA 21900233 Crystal structure of ClpP in tetradecameric form from Staphylococcus aureus 2011-07-09 2011-09-07 Zhang, J.,Ye, F.,Lan, L.,Jiang, H.,Luo, C.,Yang, C.-G. Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics J.Biol.Chem. 2011 286 37590 37601 3OZO Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT 2010-09-27 2011-09-28 Zhang, H.,Liu, T.,Liu, F.,Shen, X.,Yang, Q. Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT To be Published 0 0 0 0 3SHW Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide 2011-06-17 2011-09-28 Pan, L.,Chen, J.,Yu, J.,Yu, H.,Zhang, M. The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Suggests a Supramodular Organization of the Conserved MAGUK Family Scaffold Core To be Published 0 0 0 0 3TBM 21949752 Crystal structure of a type 4 CDGSH iron-sulfur protein. 2011-08-07 2011-10-05 Lin, J.,Zhang, L.,Lai, S.,Ye, K. Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains. Plos One 2011 6 0 0 3TBN 21949752 Crystal structure of a miner2 homolog: a type 6 CDGSH iron-sulfur protein. 2011-08-07 2011-10-05 Lin, J.,Zhang, L.,Lai, S.,Ye, K. Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains. Plos One 2011 6 0 0 3TBO 21949752 Crystal structure of a type 3 CDGSH iron-sulfur protein. 2011-08-07 2011-10-05 Lin, J.,Zhang, L.,Lai, S.,Ye, K. Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains. Plos One 2011 6 0 0 3TKP 21916849 Crystal structure of full-length human peroxiredoxin 4 in the reduced form 2011-08-28 2011-10-05 Wang, X.,Wang, L.,Wang, X.,Sun, F.,Wang, C.-C. Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J. 2011 0 0 0 3AYC 21949831 Crystal structure of galectin-3 CRD domian complexed with GM1 pentasaccharide 2011-05-04 2011-10-12 Bian, C.F.,Zhang, Y.,Sun, H.,Li, D.F.,Wang, D.C. Structural basis for distinct binding properties of the human galectins to thomsen-friedenreich antigen Plos One 2011 6 0 0 3AYD 21949831 Crystal structure of galectin-3 CRD domian complexed with TFN 2011-05-04 2011-10-12 Bian, C.F.,Zhang, Y.,Sun, H.,Li, D.F.,Wang, D.C. Structural basis for distinct binding properties of the human galectins to thomsen-friedenreich antigen Plos One 2011 6 0 0 3SP4 21984208 Crystal structure of aprataxin ortholog Hnt3 from Schizosaccharomyces pombe 2011-07-01 2011-10-12 Gong, Y.,Zhu, D.,Ding, J.,Dou, C.,Ren, X.,Gu, L.,Jiang, T.,Wang, D. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA Nat.Struct.Mol.Biol. 2011 18 1297 1299 3SPD 21984208 Crystal structure of aprataxin ortholog Hnt3 in complex with DNA 2011-07-01 2011-10-12 Gong, Y.,Zhu, D.,Ding, J.,Dou, C.,Ren, X.,Gu, L.,Jiang, T.,Wang, D. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA Nat.Struct.Mol.Biol. 2011 18 1297 1299 3SPL 21984208 Crystal structure of aprataxin ortholog Hnt3 in complex with DNA and AMP 2011-07-02 2011-10-12 Gong, Y.,Zhu, D.,Ding, J.,Dou, C.,Ren, X.,Gu, L.,Jiang, T.,Wang, D. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA Nat.Struct.Mol.Biol. 2011 18 1297 1299 3TAC 21855798 Crystal Structure of the Liprin-alpha/CASK complex 2011-08-03 2011-10-12 Wei, Z.,Zheng, S.,Spangler, S.A.,Yu, C.,Hoogenraad, C.C.,Zhang, M. Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures Mol.Cell 2011 43 586 598 3TAD 21855798 Crystal Structure of the Liprin-alpha/Liprin-beta complex 2011-08-04 2011-10-12 Wei, Z.,Zheng, S.,Spangler, S.A.,Yu, C.,Hoogenraad, C.C.,Zhang, M. Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures Mol.Cell 2011 43 586 598 3RER 21979921 Crystal structure of E. coli Hfq in complex with AU6A RNA and ADP 2011-04-05 2011-10-19 Wang, W.,Wang, L.,Zou, Y.,Zhang, J.,Gong, Q.,Wu, J.,Shi, Y. Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes Dev. 2011 25 2106 2117 3RES 21979921 Crystal structure of E coli Hfq in complex with ADP 2011-04-05 2011-10-19 Wang, W.,Wang, L.,Zou, Y.,Zhang, J.,Gong, Q.,Wu, J.,Shi, Y. Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes Dev. 2011 25 2106 2117 3R24 22022266 Crystal structure of nsp10/nsp16 complex of SARS coronavirus 2011-03-13 2011-10-26 Chen, Y.,Su, C.,Ke, M.,Jin, X.,Xu, L.,Zhang, Z.,Wu, A.,Sun, Y.,Yang, Z.,Tien, P.,Ahola, T.,Liang, Y.,Liu, X.,Guo, D. Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. Plos Pathog. 2011 7 0 0 3RPM 22013074 Crystal structure of the first GH20 domain of a novel Beta-N-acetyl-hexosaminidase StrH from Streptococcus pneumoniae R6 2011-04-27 2011-10-26 Jiang, Y.L.,Yu, W.L.,Zhang, J.W.,Frolet, C.,Di Guilmi, A.-M.,Zhou, C.Z.,Vernet, T.,Chen, Y. Structural basis for the substrate specificity of a novel beta-N-acetylhexosaminidase StrH protein from Streptococcus pneumoniae R6 J.Biol.Chem. 2011 286 43004 43012 3PFT Crystal Structure of Untagged C54A Mutant Flavin Reductase (DszD) in Complex with FMN From Mycobacterium goodii 2010-10-29 2011-11-02 Li, Q.,Xu, P.,Ma, C.,Gu, L.,Liu, X.,Zhang, C.,Li, N.,Su, J.,Li, B.,Liu, S. The flavin reductase DSZD from a desulfurizing mycobacterium goodii strain: systemic manipulation and investigation based on the crystal structure To be Published 0 0 0 0 3U0J 22013065 Crystal structure of ADP-ribosyltransferase HopU1 of Pseudomonas syringae pv. Tomato DC3000 2011-09-28 2011-11-02 Jeong, B.-R.,Lin, Y.,Joe, A.,Guo, M.,Korneli, C.,Yang, H.,Wang, P.,Yu, M.,Cerny, R.L.,Staiger, D.,Alfano, J.R.,Xu, Y. Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity J.Biol.Chem. 2011 286 43272 43281 3SQD Crystal structure of human PTIP BRCT5/6-gamma H2AX complex 2011-07-05 2011-11-09 Yan, W.,Shao, Z.H. Crystal structure of human PTIP BRCT5/6-gamma H2AX To be Published 0 0 0 0 3SWJ 22020097 Crystal structure of Campylobacter jejuni ChuZ 2011-07-14 2011-11-09 Zhang, R.,Zhang, J.,Guo, G.,Mao, X.,Tong, W.,Zhang, Y.,Wang, D.C.,Hu, Y.,Zou, Q. Crystal structure of Campylobacter jejuni ChuZ: a split-barrel family heme oxygenase with a novel heme-binding mode. Biochem.Biophys.Res.Commun. 2011 415 82 87 3PCU 22384078 Crystal structure of human retinoic X receptor alpha ligand-binding domain complexed with LX0278 and SRC1 peptide 2010-10-22 2011-11-16 Zhang, Y.,Zhang, H.,Yao, X.G.,Shen, H.,Chen, J.,Li, C.,Chen, L.,Zheng, M.,Ye, J.,Hu, L.,Shen, X.,Jiang, H. (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice. Plos One 2012 7 0 0 3TI4 22028647 Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with laninamivir octanoate 2011-08-20 2011-11-16 Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog. 2011 7 0 0 3TI5 22028647 Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with Zanamivir 2011-08-20 2011-11-16 Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog. 2011 7 0 0 3TIB 22028647 Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir octanoate 2011-08-20 2011-11-16 Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog. 2011 7 0 0 3U1L 21957909 Structure of the mRNA splicing complex component Cwc2 2011-09-30 2011-11-16 Lu, P.,Lu, G.,Yan, C.,Wang, L.,Li, W.,Yin, P. Structure of the mRNA splicing complex component Cwc2: insights into RNA recognition Biochem.J. 2012 441 591 597 3UDB Crystal structure of SnRK2.6 2011-10-27 2011-11-16 Xie, T.,Ren, R.,Pang, Y.,Yan, C. Molecular mechanism for the inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by the protein phosphatase ABI1 to be published 0 0 0 0 3T6R 22100450 Structure of UHRF1 in complex with unmodified H3 N-terminal tail 2011-07-29 2011-11-23 Xie, S.,Jakoncic, J.,Qian, C.M. UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail J.Mol.Biol. 2012 415 318 328 3TI6 22028647 Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with oseltamivir 2011-08-20 2011-11-23 Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog. 2011 7 0 0 3TON 22058037 Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase 2011-09-06 2011-11-23 Ren, L.M.,Qin, X.H.,Cao, X.F.,Wang, L.L.,Bai, F.,Bai, G.,Shen, Y. Structural insight into substrate specificity of human intestinal maltase-glucoamylase Protein Cell 2011 2 827 836 3TOP 22058037 Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase in Complex with Acarbose 2011-09-06 2011-11-23 Ren, L.M.,Qin, X.H.,Cao, X.F.,Wang, L.L.,Bai, F.,Bai, G.,Shen, Y. Structural insight into substrate specificity of human intestinal maltase-glucoamylase Protein Cell 2011 2 827 836 3TPJ 22194329 APO structure of BACE1 2011-09-08 2011-11-23 Xu, Y.C.,Li, M.J.,Greenblatt, H.,Chen, W.Y.,Paz, A.,Dym, O.,Peleg, Y.,Chen, T.T.,Shen, X.,He, J.H.,Jiang, H.L.,Silman, I.,Sussman, J.L. Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Acta Crystallogr.,Sect.D 2012 68 13 25 3TPL 22194329 APO Structure of BACE1 2011-09-08 2011-11-23 Xu, Y.C.,Li, M.J.,Greenblatt, H.,Chen, W.Y.,Paz, A.,Dym, O.,Peleg, Y.,Chen, T.T.,Shen, X.,He, J.H.,Jiang, H.L.,Silman, I.,Sussman, J.L. Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Acta Crystallogr.,Sect.D 2012 68 13 25 3UEM 22090031 Crystal structure of human PDI bb'a' domains 2011-10-30 2011-11-23 Wang, C.,Yu, J.,Huo, L.,Wang, L.,Feng, W.,Wang, C.-C. Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a' J.Biol.Chem. 2012 287 1139 1149 3ZWO 22138343 Crystal structure of ADP ribosyl cyclase complexed with reaction intermediate 2011-08-02 2011-11-30 Kotaka, M.,Graeff, R.,Chen, Z.,Zhang, L.H.,Lee, H.C.,Hao, Q. Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase. J.Mol.Biol. 2012 415 514 0 3ZWP 22138343 Crystal structure of ADP ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.1 angstrom 2011-08-02 2011-11-30 Kotaka, M.,Graeff, R.,Chen, Z.,Zhang, L.H.,Lee, H.C.,Hao, Q. Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase. J.Mol.Biol. 2012 415 514 0 3ZWV 22138343 Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom 2011-08-03 2011-11-30 Kotaka, M.,Graeff, R.,Chen, Z.,Zhang, L.H.,Lee, H.C.,Hao, Q. Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase. J. Mol. Biol. 2012 415 514 526 3ZWW 22138343 Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3 angstrom 2011-08-03 2011-11-30 Kotaka, M.,Graeff, R.,Chen, Z.,Zhang, L.H.,Lee, H.C.,Hao, Q. Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase. J.Mol.Biol. 2012 415 514 0 3UAT 22117215 Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-Protein Binding Modules 2011-10-22 2011-12-07 Zhu, J.,Shang, Y.,Xia, C.,Wang, W.,Wen, W.,Zhang, M. Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules Embo J. 2011 0 0 0 3UNW 22049910 Crystal Structure of Human GAC in Complex with Glutamate 2011-11-16 2011-12-07 DeLaBarre, B.,Gross, S.,Fang, C.,Gao, Y.,Jha, A.,Jiang, F.,Song J, J.,Wei, W.,Hurov, J.B. Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 2011 50 10764 10770 3UO9 22049910 Crystal Structure of Human GAC in Complex with Glutamate and BPTES 2011-11-16 2011-12-07 DeLaBarre, B.,Gross, S.,Fang, C.,Gao, Y.,Jha, A.,Jiang, F.,Song J, J.,Wei, W.,Hurov, J.B. Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 2011 50 10764 10770 3RJX 22128157 Crystal Structure of Hyperthermophilic Endo-Beta-1,4-glucanase 2011-04-15 2011-12-14 Zheng, B.,Yang, W.,Zhao, X.,Wang, Y.,Lou, Z.,Rao, Z.,Feng, Y. Crystal structure of hyperthermophilic endo-beta-1,4-glucanase: implications for catalytic mechanism and thermostability. J.Biol.Chem. 2012 287 8336 8346 3RL7 21858148 Crystal structure of hDLG1-PDZ1 complexed with APC 2011-04-19 2011-12-14 Zhang, Z.,Li, H.,Chen, L.,Lu, X.,Zhang, J.,Xu, P.,Lin, K.,Wu, G. Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein. Plos One 2011 6 0 0 3RL8 21858148 Crystal structure of hDLG1-PDZ2 complexed with APC 2011-04-19 2011-12-14 Zhang, Z.,Li, H.,Chen, L.,Lu, X.,Zhang, J.,Xu, P.,Lin, K.,Wu, G. Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein. Plos One 2011 6 0 0 3T7U 21871439 A NeW Crystal structure of APC-ARM 2011-07-31 2011-12-14 Zhang, Z.,Lin, K.,Gao, L.,Chen, L.,Shi, X.,Wu, G. Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility Biochem.Biophys.Res.Commun. 2011 412 732 736 3UA3 22143770 Crystal Structure of Protein Arginine Methyltransferase PRMT5 in complex with SAH 2011-10-20 2011-12-14 Sun, L.,Wang, M.,Lv, Z.,Yang, N.,Liu, Y.,Bao, S.,Gong, W.,Xu, R.M. Structural insights into protein arginine symmetric dimethylation by PRMT5 Proc.Natl.Acad.Sci.USA 2011 108 20538 20543 3UA4 22143770 Crystal Structure of Protein Arginine Methyltransferase PRMT5 2011-10-21 2011-12-14 Sun, L.,Wang, M.,Lv, Z.,Yang, N.,Liu, Y.,Bao, S.,Gong, W.,Xu, R.M. Structural insights into protein arginine symmetric dimethylation by PRMT5 Proc.Natl.Acad.Sci.USA 2011 108 20538 20543 3UAH 22117216 Structure of the Shq1 specific domain from Saccharomyces cerevisiae 2011-10-21 2011-12-14 Li, S.,Duan, J.,Li, D.,Ma, S.,Ye, K. Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita Embo J. 2011 30 5010 5020 3UAI 22117216 Structure of the Shq1-Cbf5-Nop10-Gar1 complex from Saccharomyces cerevisiae 2011-10-21 2011-12-14 Li, S.,Duan, J.,Li, D.,Ma, S.,Ye, K. Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita Embo J. 2011 30 5010 5020 3UDF 22050378 Crystal structure of Apo PBP1a from Acinetobacter baumannii 2011-10-28 2011-12-14 Han, S.,Caspers, N.,Zaniewski, R.P.,Lacey, B.M.,Tomaras, A.P.,Feng, X.,Geoghegan, K.F.,Shanmugasundaram, V. Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics J.Am.Chem.Soc. 2011 133 20536 20545 3UDI 22050378 Crystal structure of Acinetobacter baumannii PBP1a in complex with penicillin G 2011-10-28 2011-12-14 Han, S.,Caspers, N.,Zaniewski, R.P.,Lacey, B.M.,Tomaras, A.P.,Feng, X.,Geoghegan, K.F.,Shanmugasundaram, V. Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics J.Am.Chem.Soc. 2011 133 20536 20545 3UDX 22050378 Crystal structure of Acinetobacter baumannii PBP1a in complex with Imipenem 2011-10-28 2011-12-14 Han, S.,Caspers, N.,Zaniewski, R.P.,Lacey, B.M.,Tomaras, A.P.,Feng, X.,Geoghegan, K.F.,Shanmugasundaram, V. Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics J.Am.Chem.Soc. 2011 133 20536 20545 3UE0 22050378 Crystal structure of Acinetobacter baumannii PBP1a in complex with Aztreonam 2011-10-28 2011-12-14 Han, S.,Caspers, N.,Zaniewski, R.P.,Lacey, B.M.,Tomaras, A.P.,Feng, X.,Geoghegan, K.F.,Shanmugasundaram, V. Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics J.Am.Chem.Soc. 2011 133 20536 20545 3UE3 22050378 Crystal structure of Acinetobacter baumanni PBP3 2011-10-28 2011-12-14 Han, S.,Caspers, N.,Zaniewski, R.P.,Lacey, B.M.,Tomaras, A.P.,Feng, X.,Geoghegan, K.F.,Shanmugasundaram, V. Distinctive attributes of beta-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics J.Am.Chem.Soc. 2011 133 20536 20545 3UQH Crystal structure of aba receptor pyl10 (apo) 2011-11-20 2011-12-14 Sun, D.M.,Wang, H.P.,Wu, M.H.,Zang, J.Y.,Tian, C.L. Crystal Structure of Aba Receptor Pyl10 To be Published 0 0 0 0 3USW 22325779 Crystal structure of FliG (residues 86-343) from H. pylori 2011-11-24 2011-12-14 Lam, K.H.,Ip, W.S.,Lam, Y.W.,Chan, S.O.,Ling, T.K.W.,Au, S.W.N. Multiple conformations of the FliG C-terminal domain provide insight into flagellar motor switching Structure 2012 20 315 325 3USY 22325779 Crystal structure of Flig (residue 116-343) from H. Pylori 2011-11-24 2011-12-14 Lam, K.H.,Ip, W.S.,Lam, Y.W.,Chan, S.O.,Ling, T.K.W.,Au, S.W.N. Multiple conformations of the FliG C-terminal domain provide insight into flagellar motor switching Structure 2012 20 315 325 3Q4Z 22153498 Structure of unphosphorylated PAK1 kinase domain 2010-12-26 2011-12-21 Wang, J.,Wu, J.-W.,Wang, Z.-X. Structural insights into the autoactivation mechanism of p21-activated protein kinase Structure 2011 19 1752 1761 3Q52 22153498 Structure of phosphorylated PAK1 kinase domain 2010-12-26 2011-12-21 Wang, J.,Wu, J.-W.,Wang, Z.-X. Structural insights into the autoactivation mechanism of p21-activated protein kinase Structure 2011 19 1752 1761 3Q53 22153498 Structure of phosphorylated PAK1 kinase domain in complex with ATP 2010-12-26 2011-12-21 Wang, J.,Wu, J.-W.,Wang, Z.-X. Structural insights into the autoactivation mechanism of p21-activated protein kinase Structure 2011 19 1752 1761 3R6P Crystal structure of abscisic acid-bound PYL10 2011-03-22 2011-12-21 Sun, D.M.,Wu, M.H.,Wang, H.P.,Zang, J.Y.,Tian, C.L. Crystal structure of abscisic acid-bound PYL10 To be Published 0 0 0 0 3ROK 22142305 Crystal structure of human CD38 in complex with compound CZ-27 2011-04-26 2011-12-21 Kwong, A.K.,Chen, Z.,Zhang, H.,Leung, F.P.,Lam, C.M.,Ting, K.Y.,Zhang, L.,Hao, Q.,Zhang, L.H.,Lee, H.C. Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry 2012 51 555 564 3ROM 22142305 Crystal structure of human CD38 in complex with compound CZ-48 2011-04-26 2011-12-21 Kwong, A.K.,Chen, Z.,Zhang, H.,Leung, F.P.,Lam, C.M.,Ting, K.Y.,Zhang, L.,Hao, Q.,Zhang, L.H.,Lee, H.C. Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry 2012 51 555 564 3UYJ Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG 2011-12-06 2011-12-21 Su, X.,Li, H. Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG To be Published 0 0 0 0 3ROP 22142305 Crystal structure of human CD38 in complex with compound CZ-50b 2011-04-26 2011-12-28 Kwong, A.K.,Chen, Z.,Zhang, H.,Leung, F.P.,Lam, C.M.,Ting, K.Y.,Zhang, L.,Hao, Q.,Zhang, L.H.,Lee, H.C. Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry 2012 51 555 564 3SHT 22154951 Crystal structure of human MCPH1 tandem BRCT domains 2011-06-17 2011-12-28 Shao, Z.H.,Li, F.D.,Sy, S.M.-H.,Yan, W.,Zhang, Z.,Gong, D.,Wen, B.,Huen, M.S.Y.,Gong, Q.,Wu, J.,Shi, Y. Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure J.Struct.Biol. 2012 177 459 468 3SHV 22154951 Crystal structure of human MCPH1 tandem BRCT domains-gamma H2AX complex 2011-06-17 2011-12-28 Shao, Z.H.,Li, F.D.,Sy, S.M.-H.,Yan, W.,Zhang, Z.,Gong, D.,Wen, B.,Huen, M.S.Y.,Gong, Q.,Wu, J.,Shi, Y. Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure J.Struct.Biol. 2012 177 459 468 3Q9S Crystal structure of rra(1-215) from Deinococcus Radiodurans 2011-01-09 2012-01-11 Liu, Y.,Gao, Z.Q.,Dong, Y.H.,Ji, C.N. Crystal structure of rra(1-215) from Deinococcus Radiodurans To be Published 0 0 0 0 3TL8 22169508 The AvrPtoB-BAK1 complex reveals two structurally similar kinaseinteracting domains in a single type III effector 2011-08-29 2012-01-11 Cheng, W.,Munkvold, K.R.,Gao, H.,Mathieu, J.,Schwizer, S.,Wang, S.,Yan, Y.B.,Wang, J.,Martin, G.B.,Chai, J. Structural Analysis of Pseudomonas syringae AvrPtoB Bound to Host BAK1 Reveals Two Similar Kinase-Interacting Domains in a Type III Effector. Cell Host Microbe 2011 10 616 626 3V6P 22223738 Crystal structure of the DNA-binding domain of dHax3, a TAL effector 2011-12-20 2012-01-18 Deng, D.,Yan, C.Y.,Pan, X.J.,Mahfouz, M.,Wang, J.W.,Zhu, J.K.,Shi, Y.G.,Yan, N. Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors Science 2012 0 0 0 3V6P 22223738 Crystal structure of the DNA-binding domain of dHax3, a TAL effector 2011-12-20 2012-01-18 Deng, D.,Yan, C.Y.,Pan, X.J.,Mahfouz, M.,Wang, J.W.,Zhu, J.K.,Shi, Y.G.,Yan, N. Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors Science 2012 0 0 0 3PYG Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) in complex with ADP 2010-12-13 2012-01-25 Shan, S.,Chen, X.H.,Liu, T.,Zhao, H.C.,Rao, Z.H.,Lou, Z.Y. The Structural Basis for anti-TB Drug Discovery targeting of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis To be Published 0 0 0 0 3QE6 22573331 Mouse PACSIN 3 F-BAR domain structure 2011-01-19 2012-01-25 Bai, X.,Meng, G.,Luo, M.,Zheng, X. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules J.Biol.Chem. 2012 287 22387 22396 3T0H 22318716 Structure insights into mechanisms of ATP hydrolysis and the activation of human Hsp90 2011-07-20 2012-01-25 Li, J.,Sun, L.,Xu, C.,Yu, F.,Zhou, H.,Zhao, Y.,Zhang, J.,Cai, J.,Mao, C.,Tang, L.,Xu, Y.,He, J. Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. Acta Biochim Biophys Sin (Shan 2012 44 300 306 3T0Z 22318716 Hsp90 N-terminal domain bound to ATP 2011-07-21 2012-01-25 Li, J.,Sun, L.,Xu, C.,Yu, F.,Zhou, H.,Zhao, Y.,Zhang, J.,Cai, J.,Mao, C.,Tang, L.,Xu, Y.,He, J. Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. Acta Biochim Biophys Sin (Shan 2012 44 300 306 3T10 22318716 HSP90 N-terminal domain bound to ACP 2011-07-21 2012-01-25 Li, J.,Sun, L.,Xu, C.,Yu, F.,Zhou, H.,Zhao, Y.,Zhang, J.,Cai, J.,Mao, C.,Tang, L.,Xu, Y.,He, J. Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. Acta Biochim Biophys Sin (Shan 2012 44 300 306 3T1K HSP90 N-terminal domain bound to ANP 2011-07-22 2012-01-25 Li, J. HSP90 N-terminal domain bound to ANP To be published 0 0 0 0 3T2S HSP90 N-terminal domain bound to AGS 2011-07-23 2012-01-25 Li, J. HSP90 N-terminal domain bound to AGS To be published 0 0 0 0 3UMZ 22234877 Crystal Structure of the human MDC1 FHA Domain 2011-11-15 2012-01-25 Liu, J.,Luo, S.,Zhao, H.,Liao, J.,Li, J.,Yang, C.,Xu, B.,Stern, D.F.,Xu, X.,Ye, K. Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain Nucleic Acids Res. 2012 40 3898 3912 3UNM 22234877 Crystal Structure of The Human MDC1 FHA Domain 2011-11-16 2012-01-25 Liu, J.,Luo, S.,Zhao, H.,Liao, J.,Li, J.,Yang, C.,Xu, B.,Stern, D.F.,Xu, X.,Ye, K. Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain Nucleic Acids Res. 2012 40 3898 3912 3UV0 22273583 Crystal structure of the drosophila MU2 FHA domain 2011-11-29 2012-01-25 Luo, S.,Ye, K. Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1 Febs Lett. 2012 586 344 349 3SLU 22046377 Crystal structure of NMB0315 2011-06-26 2012-02-01 Wang, X.,Yang, X.,Yang, C.,Wu, Z.,Xu, H.,Shen, Y. Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis. Plos One 2011 6 0 0 3SLU 22046377 Crystal structure of NMB0315 2011-06-26 2012-02-01 Wang, X.,Yang, X.,Yang, C.,Wu, Z.,Xu, H.,Shen, Y. Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis. Plos One 2011 6 0 0 3TUO 22241778 Crystal structure of N-terminal domain of DNA-binding protein satb1 2011-09-17 2012-02-01 Wang, Z.,Yang, X.,Chu, X.,Zhang, J.,Zhou, H.,Shen, Y.,Long, J. The structural basis for the oligomerization of the N-terminal domain of SATB1 Nucleic Acids Res. 2012 40 4193 4202 3TUO 22241778 Crystal structure of N-terminal domain of DNA-binding protein satb1 2011-09-17 2012-02-01 Wang, Z.,Yang, X.,Chu, X.,Zhang, J.,Zhou, H.,Shen, Y.,Long, J. The structural basis for the oligomerization of the N-terminal domain of SATB1 Nucleic Acids Res. 2012 40 4193 4202 3VA7 22277658 Crystal structure of the Kluyveromyces lactis Urea Carboxylase 2011-12-29 2012-02-01 Fan, C.,Chou, C.Y.,Tong, L.,Xiang, S. Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction J.Biol.Chem. 2012 287 9389 9398 3QWA 21820057 Crystal structure of Saccharomyces cerevisiae Zeta-crystallin-like quinone oxidoreductase Zta1 2011-02-27 2012-02-08 Guo, P.C.,Ma, X.X.,Bao, Z.Z.,Ma, J.D.,Chen, Y.,Zhou, C.Z. Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1 J.Struct.Biol. 2011 176 112 118 3QWB 21820057 Crystal structure of Saccharomyces cerevisiae Zeta-crystallin-like quinone oxidoreductase Zta1 complexed with NADPH 2011-02-28 2012-02-08 Guo, P.C.,Ma, X.X.,Bao, Z.Z.,Ma, J.D.,Chen, Y.,Zhou, C.Z. Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1 J.Struct.Biol. 2011 176 112 118 3R2W 22132858 Crystal Structure of UDP-glucose Pyrophosphorylase of Homo Sapiens 2011-03-14 2012-02-08 Yu, Q.,Zheng, X. The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. Biochem.J. 2012 442 283 291 3R5M 22140563 Crystal structure of RXRalphaLBD complexed with the agonist magnolol 2011-03-18 2012-02-08 Zhang, H.,Xu, X.,Chen, L.,Chen, J.,Hu, L.,Jiang, H.,Shen, X. Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). Plos One 2011 6 0 0 3R5N 22140563 Crystal structure of PPARgammaLBD complexed with the agonist magnolol 2011-03-18 2012-02-08 Zhang, H.,Xu, X.,Chen, L.,Chen, J.,Hu, L.,Jiang, H.,Shen, X. Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma). Plos One 2011 6 0 0 3R5S 22291019 Crystal structure of apo-ViuP 2011-03-19 2012-02-08 Li, N.,Zhang, C.,Li, B.,Liu, X.,Huang, Y.,Xu, S.,Gu, L. Unique iron coordination in iron-chelating molecule vibriobactin helps Vibrio cholerae evade mammalian siderocalin-mediated immune response. J.Biol.Chem. 2012 287 8912 8919 3R5T 22291019 Crystal structure of holo-ViuP 2011-03-19 2012-02-08 Li, N.,Zhang, C.,Li, B.,Liu, X.,Huang, Y.,Xu, S.,Gu, L. Unique iron coordination in iron-chelating molecule vibriobactin helps Vibrio cholerae evade mammalian siderocalin-mediated immune response. J.Biol.Chem. 2012 287 8912 8919 3RJY 22128157 Crystal Structure of Hyperthermophilic Endo-beta-1,4-glucanase in complex with substrate 2011-04-15 2012-02-08 Zheng, B.,Yang, W.,Zhao, X.,Wang, Y.,Lou, Z.,Rao, Z.,Feng, Y. Crystal structure of hyperthermophilic Endo-beta-1,4-glucanase: Implications for catalytic mechanism and thermostability. J.Biol.Chem. 2012 287 8336 8346 3AXE 21959377 The truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase V18Y/W203Y in complex with cellotetraose (cellobiose density was observed) 2011-04-04 2012-02-15 Huang, J.W.,Cheng, Y.S.,Ko, T.P.,Lin, C.Y.,Lai, H.L.,Chen, C.C.,Ma, Y.,Zheng, Y.,Huang, C.H.,Zou, P.,Liu, J.R.,Guo, R.T. Rational design to improve thermostability and specific activity of the truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase Appl.Microbiol.Biotechnol. 2012 94 111 121 3T7I 22262834 Crystal structure of Se-Met Rtt107p (residues 820-1070) 2011-07-30 2012-02-15 Li, X.,Liu, K.,Li, F.,Wang, J.,Huang, H.,Wu, J.,Shi, Y. Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair J.Biol.Chem. 2012 287 9137 9146 3T7J 22262834 Crystal structure of Rtt107p (residues 820-1070) 2011-07-30 2012-02-15 Li, X.,Liu, K.,Li, F.,Wang, J.,Huang, H.,Wu, J.,Shi, Y. Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair J.Biol.Chem. 2012 287 9137 9146 3T7K 22262834 Complex structure of Rtt107p and phosphorylated histone H2A 2011-07-30 2012-02-15 Li, X.,Liu, K.,Li, F.,Wang, J.,Huang, H.,Wu, J.,Shi, Y. Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair J.Biol.Chem. 2012 287 9137 9146 3V69 22276159 Filia-N crystal structure 2011-12-19 2012-02-15 Wang, J.,Xu, M.,Zhu, K.,Li, L.,Liu, X. The N-terminus of FILIA Forms an Atypical KH Domain with a Unique Extension Involved in Interaction with RNA. Plos One 2012 7 0 0 3QPM Crystal structure of peroxiredoxin Prx4 from Pseudosciaena crocea 2011-02-14 2012-02-22 Lian, F.M.,Mu, Y.N.,Teng, Y.B.,Ao, J.Q.,Jiang, Y.L.,He, Y.X.,Chen, Y.X.,Zhou, C.Z.,Chen, X.H. The N-terminal beta-sheet of peroxiredoxin Prx4 in the large yellow croaker Pseudosciaena crocea is critical for its peroxidase and anti-bacterial activities To be Published 0 0 0 0 3TB3 21851340 Crystal structure of the UCH domain of UCH-L5 with 6 residues deleted 2011-08-05 2012-02-22 Zhou, Z.R.,Zhang, Y.H.,Liu, S.,Song, A.X.,Hu, H.Y. Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains. Biochem.J. 2012 441 143 149 3UIT 22337881 Overall structure of Patj/Pals1/Mals complex 2011-11-06 2012-02-22 Zhang, J.,Yang, X.,Wang, Z.,Zhou, H.,Xie, X.,Shen, Y.,Long, J. Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode J.Biol.Chem. 2012 287 11132 11140 3UIT 22337881 Overall structure of Patj/Pals1/Mals complex 2011-11-06 2012-02-22 Zhang, J.,Yang, X.,Wang, Z.,Zhou, H.,Xie, X.,Shen, Y.,Long, J. Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode J.Biol.Chem. 2012 287 11132 11140 3RL2 21943705 HIV Nef derived peptide Nef73 complexed to HLA-A*0301 2011-04-19 2012-02-29 Zhang, S.,Liu, J.,Cheng, H.,Tan, S.,Qi, J.,Yan, J.,Gao, G.F. Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes Mol.Immunol. 2011 49 395 401 3V8V 22362734 Crystal structure of bifunctional methyltransferase YcbY (RlmLK) from Escherichia coli, SAM binding 2011-12-23 2012-02-29 Wang, K.T.,Desmolaize, B.,Nan, J.,Zhang, X.W.,Li, L.F.,Douthwaite, S.,Su, X.D. Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA Nucleic Acids Res. 2012 40 5138 5148 3V97 22362734 Crystal structure of bifunctional methyltransferase YcbY (RlmLK) from Escherichia coli, SAH binding 2011-12-23 2012-02-29 Wang, K.T.,Desmolaize, B.,Nan, J.,Zhang, X.W.,Li, L.F.,Douthwaite, S.,Su, X.D. Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA Nucleic Acids Res. 2012 40 5138 5148 3V9R 22325783 Crystal structure of Saccharomyces cerevisiae MHF complex 2011-12-28 2012-02-29 Yang, H.,Zhang, T.,Tao, Y.,Wu, L.,Li, H.T.,Zhou, J.Q.,Zhong, C.,Ding, J. Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer Structure 2012 20 364 370 3RO2 21816348 Structures of the LGN/NuMA complex 2011-04-25 2012-03-07 Zhu, J.,Wen, W.,Zheng, Z.,Shang, Y.,Wei, Z.,Xiao, Z.,Pan, Z.,Du, Q.,Wang, W.,Zhang, M. LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G[alpha]i/LGN/NuMA pathways Mol.Cell 2011 43 418 431 3RO3 21816348 crystal structure of LGN/mInscuteable complex 2011-04-25 2012-03-07 Zhu, J.,Wen, W.,Zheng, Z.,Shang, Y.,Wei, Z.,Xiao, Z.,Pan, Z.,Du, Q.,Wang, W.,Zhang, M. LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G[alpha]i/LGN/NuMA pathways Mol.Cell 2011 43 418 431 3TO8 Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L) 2011-09-04 2012-03-07 Zhang, W.J.,Zeng, F.X.,Liu, Y.W.,Zhao, Y.,Niu, L.W.,Teng, M.K.,Li, X. Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L) To be Published 0 0 0 0 4DNU 22388820 Crystal structure of the W285A mutant of UVB-resistance protein UVR8 2012-02-09 2012-03-07 Wu, D.,Hu, Q.,Yan, Z.,Chen, W.,Yan, C.,Huang, X.,Zhang, J.,Yang, P.,Deng, H.,Wang, J.,Deng, X.,Shi, Y. Structural basis of ultraviolet-B perception by UVR8. Nature 2012 484 214 219 4DNV 22388820 Crystal structure of the W285F mutant of UVB-resistance protein UVR8 2012-02-09 2012-03-07 Wu, D.,Hu, Q.,Yan, Z.,Chen, W.,Yan, C.,Huang, X.,Zhang, J.,Yang, P.,Deng, H.,Wang, J.,Deng, X.,Shi, Y. Structural basis of ultraviolet-B perception by UVR8. Nature 2012 484 214 219 3QYT 23256035 Diferric bound human serum transferrin 2011-03-03 2012-03-14 Yang, N.,Zhang, H.,Wang, M.,Hao, Q.,Sun, H. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe Sci Rep 2012 2 999 999 3TG1 22375048 Crystal structure of p38alpha in complex with a MAPK docking partner 2011-08-17 2012-03-14 Zhang, Y.Y.,Wu, J.W.,Wang, Z.X. A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38alpha with the MAPK Binding Domain of the Phosphatase MKP5. Sci.Signal. 2011 4 0 0 4DJK 22407317 Structure of glutamate-GABA antiporter GadC 2012-02-02 2012-03-14 Ma, D.,Lu, P.L.,Yan, C.Y.,Fan, C.,Yin, P.,Wang, J.W.,Shi, Y.G. Structure and mechanism of a glutamate-GABA antiporter Nature 2012 483 632 636 3R3I Crystal Structure of C-terminal truncation of UDP-glucose Pyrophosphorylase of Homo sapiens 2011-03-15 2012-03-21 Zheng, X.,Yu, Q. Crystal Structure of UDP-glucose Pyrophosphorylase of Homo sapiens To be Published 0 0 0 0 3U82 22146396 Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion 2011-10-15 2012-03-21 Zhang, N.,Yan, J.,Lu, G.,Guo, Z.,Fan, Z.,Wang, J.,Shi, Y.,Qi, J.,Gao, G.F. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nat Commun 2011 2 577 577 3U83 22146396 Crystal structure of nectin-1 2011-10-15 2012-03-21 Zhang, N.,Yan, J.,Lu, G.,Guo, Z.,Fan, Z.,Wang, J.,Shi, Y.,Qi, J.,Gao, G.F. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nat Commun 2011 2 577 577 4DOZ 22449983 Crystal structure of Pyrococcus furiosus Cmr2 (Cas10) 2012-02-12 2012-03-21 Zhu, X.,Ye, K. Crystal structure of Cmr2 suggests a nucleotide cyclase-related enzyme in type III CRISPR-Cas systems Febs Lett. 2012 586 939 945 4E0Q 22575649 Crystal structure of MPN domain from COP9 signalosome 2012-03-05 2012-03-21 Zhang, H.,Gao, Z.Q.,Wang, W.J.,Liu, G.F.,Shtykova, E.V.,Xu, J.H.,Li, L.F.,Su, X.D.,Dong, Y.H. The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6 Febs Lett. 2012 586 1147 1153 3UA0 22387468 N-Terminal Domain of Bombyx mori Fibroin Mediates the Assembly of Silk in Response to pH Decrease 2011-10-20 2012-03-28 He, Y.X.,Zhang, N.N.,Li, W.F.,Jia, N.,Chen, B.Y.,Zhou, K.,Zhang, J.,Chen, Y.,Zhou, C.Z. N-Terminal Domain of Bombyx mori Fibroin Mediates the Assembly of Silk in Response to pH Decrease. J.Mol.Biol. 2012 418 197 207 3V6M 22433863 Inhibition of caspase-6 activity by single mutation outside the active site 2011-12-20 2012-03-28 Cao, Q.,Wang, X.J.,Liu, C.W.,Liu, D.F.,Li, L.F.,Gao, Y.Q.,Su, X.D. Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem. 2012 287 15371 15379 4D8O 22411828 Crystal Structure of the ankyrin-B ZU5-ZU5-UPA-DD tandem 2012-01-11 2012-03-28 Wang, C.,Yu, C.,Ye, F.,Wei, Z.,Zhang, M. Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function Proc.Natl.Acad.Sci.USA 2012 109 4822 4827 3TEQ 22451904 Crystal structure of SOAR domain 2011-08-15 2012-04-11 Yang, X.,Jin, H.,Cai, X.,Li, S.,Shen, Y. Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1). Proc.Natl.Acad.Sci.USA 2012 109 5657 5662 3TEQ 22451904 Crystal structure of SOAR domain 2011-08-15 2012-04-11 Yang, X.,Jin, H.,Cai, X.,Li, S.,Shen, Y. Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1). Proc.Natl.Acad.Sci.USA 2012 109 5657 5662 3TER 22451904 Crystal structure of SOAR domain with Inhibition helix from C. elegans 2011-08-15 2012-04-11 Yang, X.,Jin, H.,Cai, X.,Li, S.,Shen, Y. Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1). Proc.Natl.Acad.Sci.USA 2012 109 5657 5662 3TER 22451904 Crystal structure of SOAR domain with Inhibition helix from C. elegans 2011-08-15 2012-04-11 Yang, X.,Jin, H.,Cai, X.,Li, S.,Shen, Y. Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1). Proc.Natl.Acad.Sci.USA 2012 109 5657 5662 3UBU 22447656 Crystal structure of agkisacucetin, a GpIb-binding snaclec (snake C-type lectin) that inhibits platelet 2011-10-25 2012-04-11 Gao, Y.,Ge, H.,Chen, H.,Li, H.,Liu, Y.,Chen, L.,Li, X.,Liu, J.,Niu, L.,Teng, M. Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation. Proteins 2012 0 0 0 4DSQ 22474296 Crystal structure of peroxiredoxin Ahp1 from Saccharomyces cerevisiae in oxidized form 2012-02-19 2012-04-11 Lian, F.M.,Yu, J.,Ma, X.X.,Yu, X.J.,Chen, Y.,Zhou, C.Z. Structural Snapshots of Yeast Alkyl Hydroperoxide Reductase Ahp1 Peroxiredoxin Reveal a Novel Two-cysteine Mechanism of Electron Transfer to Eliminate Reactive Oxygen Species J.Biol.Chem. 2012 287 17077 17087 4DSR 22474296 Crystal structure of peroxiredoxin Ahp1 from Saccharomyces cerevisiae in reduced form 2012-02-19 2012-04-11 Lian, F.M.,Yu, J.,Ma, X.X.,Yu, X.J.,Chen, Y.,Zhou, C.Z. Structural Snapshots of Yeast Alkyl Hydroperoxide Reductase Ahp1 Peroxiredoxin Reveal a Novel Two-cysteine Mechanism of Electron Transfer to Eliminate Reactive Oxygen Species. J.Biol.Chem. 2012 287 17077 17087 4DSS 22474296 Crystal structure of peroxiredoxin Ahp1 from Saccharomyces cerevisiae in complex with thioredoxin Trx2 2012-02-19 2012-04-11 Lian, F.M.,Yu, J.,Ma, X.X.,Yu, X.J.,Chen, Y.,Zhou, C.Z. Structural Snapshots of Yeast Alkyl Hydroperoxide Reductase Ahp1 Peroxiredoxin Reveal a Novel Two-cysteine Mechanism of Electron Transfer to Eliminate Reactive Oxygen Species. J.Biol.Chem. 2012 287 17077 17087 4DT1 22465956 Crystal structure of the Psy3-Csm2 complex 2012-02-20 2012-04-11 Tao, Y.,Li, X.,Liu, Y.,Ruan, J.,Qi, S.,Niu, L.,Teng, M. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage J.Biol.Chem. 2012 287 20231 20239 3SFV 22416225 Crystal structure of the GDP-bound Rab1a S25N mutant in complex with the coiled-coil domain of LidA from Legionella pneumophila 2011-06-14 2012-04-18 Cheng, W.,Yin, K.,Lu, D.,Li, B.,Zhu, D.,Chen, Y.,Zhang, H.,Xu, S.,Chai, J.,Gu, L. Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State Plos Pathog. 2012 8 0 0 3RY7 22198595 Crystal Structure of Sa239 2011-05-11 2012-04-25 Li, J.,Wang, C.,Wu, Y.,Wu, M.,Wang, L.,Wang, Y.,Zang, J. Crystal structure of Sa239 reveals the structural basis for the activation of ribokinase by monovalent cations. J.Struct.Biol. 2012 177 578 582 3TOE 22511977 Structure of Mth10b 2011-09-05 2012-04-25 Liu, Y.F.,Zhang, N.,Liu, X.,Wang, X.,Wang, Z.X.,Chen, Y.,Yao, H.W.,Ge, M.,Pan, X.M. Molecular mechanism underlying the interaction of typical Sac10b family proteins with DNA. Plos One 2012 7 0 0 4EJS 22556426 Structure of yeast elongator subcomplex Elp456 2012-04-07 2012-05-02 Lin, Z.,Zhao, W.,Diao, W.,Xie, X.,Wang, Z.,Zhang, J.,Shen, Y.,Long, J. Crystal structure of elongator subcomplex Elp4-6 J.Biol.Chem. 2012 287 21501 21508 3Q54 22948914 Crystal structure of Escherichia coli BamB 2010-12-27 2012-05-09 Dong, C.,Yang, X.,Hou, H.F.,Shen, Y.Q.,Dong, Y.H. Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA. Acta Crystallogr.,Sect.D 2012 68 1134 1139 3UB2 22485159 TIR domain of Mal/TIRAP 2011-10-23 2012-05-16 Lin, Z.,Lu, J.,Zhou, W.,Shen, Y. Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling Plos One 2012 7 0 0 3UB3 22485159 D96N variant of TIR domain of Mal/TIRAP 2011-10-23 2012-05-16 Lin, Z.,Lu, J.,Zhou, W.,Shen, Y. Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling Plos One 2012 7 0 0 3UB4 22485159 S180L variant of TIR domain of Mal/TIRAP 2011-10-23 2012-05-16 Lin, Z.,Lu, J.,Zhou, W.,Shen, Y. Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling Plos One 2012 7 0 0 4DRA 22510687 Crystal structure of MHF complex 2012-02-17 2012-05-16 Tao, Y.,Jin, C.,Li, X.,Qi, S.,Chu, L.,Niu, L.,Yao, X.,Teng, M. The structure of the FANCM-MHF complex reveals physical features for functional assembly Nat Commun 2012 3 782 782 4DRB 22510687 The crystal structure of FANCM bound MHF complex 2012-02-17 2012-05-16 Tao, Y.,Jin, C.,Li, X.,Qi, S.,Chu, L.,Niu, L.,Yao, X.,Teng, M. The structure of the FANCM-MHF complex reveals physical features for functional assembly Nat Commun 2012 3 782 782 4EF5 22579474 Crystal structure of STING CTD 2012-03-29 2012-05-16 Ouyang, S.,Song, X.,Wang, Y.,Ru, H.,Shaw, N.,Jiang, Y.,Niu, F.,Zhu, Y.,Qiu, W.,Parvatiyar, K.,Li, Y.,Zhang, R.,Cheng, G.,Liu, Z.J. Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding Immunity 2012 36 1073 1086 3S5J 25781187 2.0A Crystal structure of human phosphoribosyl pyrophosphate synthetase 1 2011-05-23 2012-05-23 Chen, P.,Liu, Z.,Wang, X.,Peng, J.,Sun, Q.,Li, J.,Wang, M.,Niu, L.,Zhang, Z.,Cai, G.,Teng, M.,Li, X. Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One 2015 10 0 0 3UIM 22547027 Structural basis for the impact of phosphorylation on plant receptor-like kinase BAK1 activation 2011-11-05 2012-05-23 Yan, L.,Ma, Y.Y.,Liu, D.,Wei, X.,Sun, Y.,Chen, X.,Zhao, H.,Zhou, J.,Wang, Z.,Shui, W.,Lou, Z.Y. Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1 Cell Res. 2012 22 1304 1308 3V33 22561375 Crystal structure of MCPIP1 conserved domain with zinc-finger motif 2011-12-12 2012-05-23 Xu, J.,Peng, W.,Sun, Y.,Wang, X.,Xu, Y.,Li, X.,Gao, G.,Rao, Z. Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase Nucleic Acids Res. 2012 40 6957 6965 4DXW 22678295 Crystal structure of NavRh, a voltage-gated sodium channel 2012-02-28 2012-05-23 Zhang, X.,Ren, W.L.,DeCaen, P.,Yan, C.Y.,Tao, X.,Tang, L.,Wang, J.J.,Hasegawa, K.,Kumasaka, T.,He, J.H.,Wang, J.W.,Clapham, D.E.,Yan, N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel Nature 2012 486 130 134 3SR9 22027896 Crystal structure of mouse PTPsigma 2011-07-07 2012-05-30 Hou, L.,Wang, J.,Zhou, Y.,Li, J.,Zang, Y.,Li, J. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma Acta Biochim.Biophys.Sin. 2011 43 977 988 4E8C 22593580 Crystal structure of streptococcal beta-galactosidase in complex with galactose 2012-03-20 2012-05-30 Cheng, W.,Wang, L.,Jiang, Y.L.,Bai, X.H.,Chu, J.,Li, Q.,Yu, G.,Liang, Q.L.,Zhou, C.Z.,Chen, Y.X. Structural insights into the substrate specificity of Streptococcus pneumoniae beta (1,3)-galactosidase BgaC J.Biol.Chem. 2012 287 22910 22918 4E8D 22593580 Crystal structure of streptococcal beta-galactosidase 2012-03-20 2012-05-30 Cheng, W.,Wang, L.,Jiang, Y.L.,Bai, X.H.,Chu, J.,Li, Q.,Yu, G.,Liang, Q.L.,Zhou, C.Z.,Chen, Y.X. Structural insights into the substrate specificity of Streptococcus pneumoniae beta (1,3)-galactosidase BgaC J.Biol.Chem. 2012 287 22910 22918 3S57 22659876 ABH2 cross-linked with undamaged dsDNA-1 containing cofactors 2011-05-20 2012-06-06 Yi, C.,Chen, B.,Qi, B.,Zhang, W.,Jia, G.,Zhang, L.,Li, C.J.,Dinner, A.R.,Yang, C.G.,He, C. Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol. 2012 19 671 676 3S5A 22659876 ABH2 cross-linked to undamaged dsDNA-2 with cofactors 2011-05-21 2012-06-06 Yi, C.,Chen, B.,Qi, B.,Zhang, W.,Jia, G.,Zhang, L.,Li, C.J.,Dinner, A.R.,Yang, C.G.,He, C. Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol. 2012 19 671 676 4DFH 22547693 Crystal structure of cell adhesion molecule nectin-2/CD112 variable domain 2012-01-23 2012-06-06 Liu, J.,Qian, X.,Chen, Z.,Xu, X.,Gao, F.,Zhang, S.,Zhang, R.,Qi, J.,Gao, G.F.,Yan, J. Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1/CD226 J.Immunol. 2012 188 5511 5520 4DFI 22547693 Crystal structure of cell adhesion molecule nectin-2/CD112 mutant FAMP 2012-01-23 2012-06-06 Liu, J.,Qian, X.,Chen, Z.,Xu, X.,Gao, F.,Zhang, S.,Zhang, R.,Qi, J.,Gao, G.F.,Yan, J. Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1/CD226 J.Immunol. 2012 188 5511 5520 4E99 22482699 Human Serum Albumin Complex with Perfluorooctane Sulfonate Potassium 2012-03-20 2012-06-06 Luo, Z.P.,Shi, X.L.,Hu, Q.,Zhao, B.,Huang, M.D. Structural evidence of perfluorooctane sulfonate transport by human serum albumin Chem.Res.Toxicol. 2012 25 990 992 4EAG 22659875 Co-crystal structure of an chimeric AMPK core with ATP 2012-03-22 2012-06-06 Chen, L.,Wang, J.,Zhang, Y.-Y.,Yan, S.F.,Neumann, D.,Schlattner, U.,Wang, Z.-X.,Wu, J.-W. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol. 2012 19 716 718 4EAI 22659875 Co-crystal structure of an AMPK core with AMP 2012-03-22 2012-06-06 Chen, L.,Wang, J.,Zhang, Y.-Y.,Yan, S.F.,Neumann, D.,Schlattner, U.,Wang, Z.-X.,Wu, J.-W. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol. 2012 19 716 718 4EAJ 22659875 Co-crystal of AMPK core with AMP soaked with ATP 2012-03-22 2012-06-06 Chen, L.,Wang, J.,Zhang, Y.-Y.,Yan, S.F.,Neumann, D.,Schlattner, U.,Wang, Z.-X.,Wu, J.-W. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol. 2012 19 716 718 4EAK 22659875 Co-crystal structure of an AMPK core with ATP 2012-03-22 2012-06-06 Chen, L.,Wang, J.,Zhang, Y.-Y.,Yan, S.F.,Neumann, D.,Schlattner, U.,Wang, Z.-X.,Wu, J.-W. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol. 2012 19 716 718 4EAL 22659875 Co-crystal of AMPK core with ATP soaked with AMP 2012-03-22 2012-06-06 Chen, L.,Wang, J.,Zhang, Y.-Y.,Yan, S.F.,Neumann, D.,Schlattner, U.,Wang, Z.-X.,Wu, J.-W. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol. 2012 19 716 718 4ELS 22606952 Structure of E. Coli. 1,4-dihydroxy-2- naphthoyl coenzyme A synthases (MENB) in complex with bicarbonate 2012-04-11 2012-06-06 Sun, Y.R.,Song, H.G.,Li, J.,Jiang, M.,Li, Y.,Zhou, J.H.,Guo, Z.H. Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways Biochemistry 2012 51 4580 4589 4ELW 22606952 Structure of E. coli. 1,4-dihydroxy-2- naphthoyl coenzyme A synthases (MENB) in complex with nitrate 2012-04-11 2012-06-06 Sun, Y.R.,Song, H.G.,Li, J.,Jiang, M.,Li, Y.,Zhou, J.H.,Guo, Z.H. Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways Biochemistry 2012 51 4580 4589 4ELX 22606952 Structure of apo E.coli. 1,4-dihydroxy-2- naphthoyl CoA synthases with Cl 2012-04-11 2012-06-06 Sun, Y.R.,Song, H.G.,Li, J.,Jiang, M.,Li, Y.,Zhou, J.H.,Guo, Z.H. Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways Biochemistry 2012 51 4580 4589 3TJ0 22496219 Crystal Structure of Influenza B Virus Nucleoprotein 2011-08-23 2012-06-20 Ng, A.K.L.,Lam, M.K.H.,Zhang, H.,Liu, J.,Au, S.W.N.,Chan, P.K.S.,Wang, J.,Shaw, P.C. Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein J.Virol. 2012 86 6758 6767 4EML 22606952 Synechocystis sp. PCC 6803 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in complex with bicarbonate 2012-04-12 2012-06-20 Sun, Y.R.,Song, H.G.,Li, J.,Jiang, M.,Li, Y.,Zhou, J.H.,Guo, Z.H. Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways Biochemistry 2012 51 4580 4589 3TDL 21997768 Structure of human serum albumin in complex with DAUDA 2011-08-11 2012-06-27 Wang, Y.,Luo, Z.,Shi, X.,Wang, H.,Nie, L.,Huang, M. A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin Protein Sci. 2011 20 2095 2101 3TKL 22416225 Crystal structure of the GTP-bound Rab1a in complex with the coiled-coil domain of LidA from Legionella pneumophila 2011-08-27 2012-06-27 Cheng, W.,Yin, K.,Lu, D.,Li, B.,Zhu, D.,Chen, Y.,Zhang, H.,Xu, S.,Chai, J.,Gu, L. Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state Plos Pathog. 2012 8 0 0 3V43 22713874 Crystal structure of MOZ 2011-12-14 2012-06-27 Qiu, Y.,Liu, L.,Zhao, C.,Han, C.,Li, F.,Zhang, J.,Wang, Y.,Li, G.,Mei, Y.,Wu, M.,Wu, J.,Shi, Y. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription Genes Dev. 2012 26 1376 1391 4EBY 22654057 Crystal structure of the ectodomain of a receptor like kinase 2012-03-25 2012-06-27 Liu, T.,Liu, Z.,Song, C.,Hu, Y.,Han, Z.,She, J.,Fan, F.,Wang, J.,Jin, C.,Chang, J.,Zhou, J.M.,Chai, J. Chitin-induced dimerization activates a plant immune receptor. Science 2012 336 1160 1164 4EBZ 22654057 Crystal structure of the ectodomain of a receptor like kinase 2012-03-26 2012-06-27 Liu, T.,Liu, Z.,Song, C.,Hu, Y.,Han, Z.,She, J.,Fan, F.,Wang, J.,Jin, C.,Chang, J.,Zhou, J.M.,Chai, J. Chitin-induced dimerization activates a plant immune receptor. Science 2012 336 1160 1164 4F0V 22750141 Crystal structure of type effector Tse1 from Pseudomonas aeruginousa 2012-05-05 2012-06-27 Zhang, H.,Gao, Z.Q.,Su, X.D.,Dong, Y.H. Crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa. Febs Lett. 2012 586 3193 3199 4F0W 22750141 Crystal structure of type effector Tse1 C30A mutant from Pseudomonas aeruginousa 2012-05-05 2012-06-27 Zhang, H.,Gao, Z.Q.,Su, X.D.,Dong, Y.H. Crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa. Febs Lett. 2012 586 3193 3199 4F5E 22728659 Crystal structure of ERIS/STING 2012-05-13 2012-06-27 Huang, Y.H.,Liu, X.Y.,Du, X.X.,Jiang, Z.F.,Su, X.D. The structural basis for the sensing and binding of cyclic di-GMP by STING Nat.Struct.Mol.Biol. 2012 19 728 730 4F5W 22728660 Crystal structure of ligand free human STING CTD 2012-05-13 2012-06-27 Shang, G.,Zhu, D.,Li, N.,Zhang, J.,Zhu, C.,Lu, D.,Liu, C.,Yu, Q.,Zhao, Y.,Xu, S.,Gu, L. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP Nat.Struct.Mol.Biol. 2012 19 725 727 4F5Y 22728660 Crystal structure of human STING CTD complex with C-di-GMP 2012-05-13 2012-06-27 Shang, G.,Zhu, D.,Li, N.,Zhang, J.,Zhu, C.,Lu, D.,Liu, C.,Yu, Q.,Zhao, Y.,Xu, S.,Gu, L. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP Nat.Struct.Mol.Biol. 2012 19 725 727 4F7G 22710802 Crystal structure of talin autoinhibition complex 2012-05-16 2012-07-04 Song, X.,Yang, J.,Hirbawi, J.,Ye, S.,Perera, H.D.,Goksoy, E.,Dwivedi, P.,Plow, E.F.,Zhang, R.,Qin, J. A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Res. 2012 22 1533 1545 4F7G 22710802 Crystal structure of talin autoinhibition complex 2012-05-16 2012-07-04 Song, X.,Yang, J.,Hirbawi, J.,Ye, S.,Perera, H.D.,Goksoy, E.,Dwivedi, P.,Plow, E.F.,Zhang, R.,Qin, J. A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Res. 2012 22 1533 1545 3SQZ Crystal structure of HMG_CoA synthase complexed with CoA 2011-07-06 2012-07-11 Liu, Y.H.,Fu, T.M.,Liu, X.,Su, X.D. Crystal structure of HMG-CoA synthase from Streptococcus mutans To be Published 0 0 0 0 3SUZ 22730553 Crystal structure of Rat Mint2 PPC 2011-07-11 2012-07-11 Xie, X.,Yan, X.,Wang, Z.,Zhou, H.,Diao, W.,Zhou, W.,Long, J.,Shen, Y. Open-closed motion of Mint2 regulates APP metabolism J Mol Cell Biol 2013 5 48 56 3SV1 22730553 Crystal structure of APP peptide bound rat Mint2 PARM 2011-07-12 2012-07-11 Xie, X.,Yan, X.,Wang, Z.,Zhou, H.,Diao, W.,Zhou, W.,Long, J.,Shen, Y. Open-closed motion of Mint2 regulates APP metabolism J Mol Cell Biol 2013 5 48 56 3URF 22664871 Human RANKL/OPG complex 2011-11-22 2012-07-11 Luan, X.D.,Lu, Q.Y.,Jiang, Y.N.,Zhang, S.Y.,Wang, Q.,Yuan, H.H.,Zhao, W.M.,Wang, J.W.,Wang, X.Q. Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin J.Immunol. 2012 189 245 252 3VHN 22170108 Y61G mutant of Cellulase 12A from thermotoga maritima 2011-08-30 2012-07-11 Cheng, Y.-S.,Ko, T.-P.,Huang, J.W.,Wu, T.H.,Lin, C.Y.,Luo, W.,Li, Q.,Ma, Y.,Huang, C.H.,Wang, A.H.,Liu, J.-R.,Guo, R.-T. Enhanced activity of Thermotoga maritima cellulase 12A by mutating a unique surface loop Appl.Microbiol.Biotechnol. 2012 95 661 669 4DC2 22579248 Structure of PKC in Complex with a Substrate Peptide from Par-3 2012-01-17 2012-07-11 Wang, C.,Shang, Y.,Yu, J.,Zhang, M. Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKC iota in complex with a substrate peptide from Par-3 Structure 2012 20 791 801 4F6O 22761449 Crystal structure of the yeast metacaspase Yca1 2012-05-15 2012-07-11 Wong, A.H.,Yan, C.,Shi, Y. Crystal structure of the yeast metacaspase Yca1. J.Biol.Chem. 2012 287 29251 29259 3T9K 22645133 Crystal Structure of ACAP1 C-portion mutant S554D fused with integrin beta1 peptide 2011-08-03 2012-07-18 Bai, M.,Pang, X.,Lou, J.,Zhou, Q.,Zhang, K.,Ma, J.,Li, J.,Sun, F.,Hsu, V.W. Mechanistic insights into regulated cargo binding by ACAP1 protein J.Biol.Chem. 2012 287 28675 28685 4FI9 22945352 Structure of human SUN-KASH complex 2012-06-08 2012-07-18 Wang, W.,Shi, Z.,Jiao, S.,Chen, C.,Wang, H.,Liu, G.,Wang, Q.,Zhao, Y.,Greene, M.I.,Zhou, Z. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Res. 2012 22 1440 1452 3T5T Vall from streptomyces hygroscopicus in apo form 2011-07-28 2012-08-01 Zhang, H.,Zheng, L.,Qian, H. Structural basis for the substrate specificity of ValL To be Published 0 0 0 0 3T7D Vall from streptomyces hygroscopicus in complex with trehalose 2011-07-29 2012-08-01 Zhang, H.,Zheng, L.,Qian, H.,Chen, J. Structural basis for the substrate specificity of ValL To be Published 0 0 0 0 4EQ6 22749910 The crystal structure of Psy3-Csm2 complex from budding yeast 2012-04-18 2012-08-01 She, Z.,Gao, Z.Q.,Liu, Y.,Wang, W.J.,Liu, G.F.,Shtykova, E.V.,Xu, J.H.,Dong, Y.H. Structural and SAXS analysis of the budding yeast SHU-complex proteins FEBS Lett. 2012 586 2306 2312 4G3H Crystal structure of helicobacter pylori arginase 2012-07-13 2012-08-01 Zhang, J.,Zhang, X.,Li, D.,Hu, Y.,Zou, Q.,Wang, D. Structure and function studies on Helicobacter pylori arginase To be Published 0 0 0 0 4F1Z 22719251 Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB 2012-05-07 2012-08-08 Xiang, H.,Feng, Y.,Wang, J.W.,Liu, B.,Chen, Y.G.,Liu, L.,Deng, X.M.,Yang, M.J. Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog. 2012 8 0 0 4F20 22719251 Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB 2012-05-07 2012-08-08 Xiang, H.,Feng, Y.,Wang, J.W.,Liu, B.,Chen, Y.G.,Liu, L.,Deng, X.M.,Yang, M.J. Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog. 2012 8 0 0 4F24 22719251 Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB 2012-05-07 2012-08-08 Xiang, H.,Feng, Y.,Wang, J.W.,Liu, B.,Chen, Y.G.,Liu, L.,Deng, X.M.,Yang, M.J. Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog. 2012 8 0 0 4F27 22719251 Crystal structures reveal the multi-ligand binding mechanism of the Staphylococcus aureus ClfB 2012-05-07 2012-08-08 Xiang, H.,Feng, Y.,Wang, J.W.,Liu, B.,Chen, Y.G.,Liu, L.,Deng, X.M.,Yang, M.J. Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB Plos Pathog. 2012 8 0 0 3TEF 22575663 Crystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio Cholerae 2011-08-13 2012-08-15 Liu, X.,Du, Q.,Wang, Z.,Liu, S.,Li, N.,Chen, Y.,Zhu, C.,Zhu, D.,Wei, T.,Huang, Y.,Xu, S.,Gu, L. Crystal structure of periplasmic catecholate-siderophore binding protein VctP from Vibrio cholerae at 1.7 A resolution Febs Lett. 2012 586 1240 1244 4DO1 22695988 The crystal structures of 4-methoxybenzoate bound CYP199A4 2012-02-09 2012-08-15 Bell, S.G.,Yang, W.,Tan, A.B.H.,Zhou, R.,Johnson, E.O.D.,Zhang, A.,Zhou, W.,Rao, Z.,Wong, L.-L. The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site Dalton Trans 2012 41 8703 8714 4G1C 22849721 Human SIRT5 bound to Succ-IDH2 and Carba-NAD 2012-07-10 2012-08-15 Szczepankiewicz, B.G.,Dai, H.,Koppetsch, K.J.,Qian, D.,Jiang, F.,Mao, C.,Perni, R.B. Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. J.Org.Chem. 2012 77 7319 7329 4G1T 22825553 Crystal structure of interferon-stimulated gene 54 2012-07-11 2012-08-15 Yang, Z.,Liang, H.,Zhou, Q.,Li, Y.,Chen, H.,Ye, W.,Chen, D.,Fleming, J.,Shu, H.,Liu, Y. Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. Cell Res. 2012 22 1328 1338 3TGV Crystal structure of HutZ,the heme storsge protein from Vibrio cholerae 2011-08-17 2012-08-22 Liu, X.,Gong, J.,Wang, Z.,Du, Q.,Wei, T.,Zhu, D.,Huang, Y.,Xu, S.,Gu, L. Crystal structure of HutZ,the heme storsge protein from Vibrio cholerae To be Published 0 0 0 0 3TG2 22993087 Crystal structure of the ISC domain of VibB in complex with isochorismate 2011-08-17 2012-08-29 Liu, S.,Zhang, C.,Li, N.,Niu, B.,Liu, M.,Liu, X.,Wei, T.,Zhu, D.,Huang, Y.,Xu, S.,Gu, L. Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction Acta Crystallogr.,Sect.D 2012 68 1329 1338 3TJT Crystal Structure Analysis of the superoxide dismutase from Clostridium difficile 2011-08-25 2012-08-29 Li, W.,Lei, C.,Ying, T.L.,Wang, H.F.,Tan, X.S. Crystal Structure of the superoxide dismutase from Clostridium difficile To be Published 0 0 0 0 4AGH 22948907 Structural features of ssDNA binding protein MoSub1 from Magnaporthe oryzae 2012-01-27 2012-08-29 Huang, J.,Zhao, Y.,Huang, D.,Liu, H.,Justin, N.,Zhao, W.,Liu, J.,Peng, Y. Structural Features of the Single-Stranded DNA-Binding Protein Mosub1 from Magnaporthe Oryzae. Acta Crystallogr.,Sect.D 2012 68 1071 0 4E0H 22910915 Crystal structure of FAD binding domain of Erv1 from Saccharomyces cerevisiae 2012-03-04 2012-08-29 Guo, P.C.,Ma, J.D.,Jiang, Y.L.,Wang, S.J.,Bao, Z.Z.,Yu, X.J.,Chen, Y.,Zhou, C.Z. Structure of yeast sulfhydryl oxidase erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space J.Biol.Chem. 2012 287 34961 34969 4E0I 22910915 Crystal structure of the C30S/C133S mutant of Erv1 from Saccharomyces cerevisiae 2012-03-04 2012-08-29 Guo, P.C.,Ma, J.D.,Jiang, Y.L.,Wang, S.J.,Bao, Z.Z.,Yu, X.J.,Chen, Y.,Zhou, C.Z. Structure of yeast sulfhydryl oxidase erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space J.Biol.Chem. 2012 287 34961 34969 4GES 22936654 crystal structure of GFP-TYR151PYZ with an unnatural amino acid incorporation 2012-08-02 2012-08-29 Liu, X.,Li, J.,Dong, J.,Hu, C.,Gong, W.,Wang, J. Genetic incorporation of a metal-chelating amino Acid as a probe for protein electron transfer. Angew.Chem.Int.Ed.Engl. 2012 51 10261 10265 4GF6 22936654 crystal structure of GFP with cuprum bound at the Incorporated metal Chelating Amino Acid PYZ151 2012-08-03 2012-08-29 Liu, X.,Li, J.,Dong, J.,Hu, C.,Gong, W.,Wang, J. Genetic incorporation of a metal-chelating amino Acid as a probe for protein electron transfer. Angew.Chem.Int.Ed.Engl. 2012 51 10261 10265 4GIW 22821014 Crystal structure of the RUN domain of human NESCA 2012-08-09 2012-08-29 Sun, Q.,Han, C.,Liu, L.,Wang, Y.,Deng, H.,Bai, L.,Jiang, T. Crystal structure and functional implication of the RUN domain of human NESCA Protein Cell 2012 3 609 617 4G5O Structure of LGN GL4/Galphai3(Q147L) complex 2012-07-18 2012-09-05 Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins To be Published 0 0 0 0 4G5Q Structure of LGN GL4/Galphai1 complex 2012-07-18 2012-09-05 Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins To be Published 0 0 0 0 4G5R Structure of LGN GL4/Galphai3 complex 2012-07-18 2012-09-05 Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins To be Published 0 0 0 0 4G5S Structure of LGN GL3/Galphai3 complex 2012-07-18 2012-09-05 Jia, M.,Li, J.,Zhu, J.,Wen, W.,Zhang, M.,Wang, W. Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins To be Published 0 0 0 0 3TLQ 23002140 Crystal structure of EAL-like domain protein YdiV 2011-08-30 2012-09-12 Li, B.,Li, N.,Wang, F.,Guo, L.,Huang, Y.,Liu, X.,Wei, T.,Zhu, D.,Liu, C.,Pan, H.,Xu, S.,Wang, H.W.,Gu, L. Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility Nucleic Acids Res. 2012 40 11073 11085 3TN3 Crystal structure of GkaP from Geobacillus kaustophilus HTA426 2011-09-01 2012-09-12 An, J.,Zhang, Z.,Zhang, Y.,Feng, Y.,Wu, G. Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides to be published 0 0 0 0 3TN5 Crystal structure of GkaP mutant Y99L from Geobacillus kaustophilus HTA426 2011-09-01 2012-09-12 An, J.,Zhang, Z.,Zhang, Y.,Feng, Y.,Wu, G. Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides to be published 0 0 0 0 3TN6 Crystal structure of GkaP mutant R230H from Geobacillus kaustophilus HTA426 2011-09-01 2012-09-12 An, J.,Zhang, Z.,Zhang, Y.,Feng, Y.,Wu, G. Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides to be published 0 0 0 0 3TNB Crystal structure of GkaP mutant G209D/R230H from Geobacillus kaustophilus HTA426 2011-09-01 2012-09-12 An, J.,Zhang, Z.,Zhang, Y.,Feng, Y.,Wu, G. Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides to be published 0 0 0 0 4EAX 22649032 Mouse NGF in complex with Lyso-PS 2012-03-23 2012-09-12 Tong, Q.,Wang, F.,Zhou, H.Z.,Sun, H.L.,Song, H.,Shu, Y.Y.,Gong, Y.,Zhang, W.T.,Cai, T.X.,Yang, F.Q.,Tang, J.,Jiang, T. Structural and functional insights into lipid-bound nerve growth factors Faseb J. 2012 26 3811 3821 4EQ8 22931054 Crystal structure of PA1844 from Pseudomonas aeruginosa PAO1 2012-04-18 2012-09-12 Shang, G.,Liu, X.,Lu, D.,Zhang, J.,Li, N.,Zhu, C.,Liu, S.,Yu, Q.,Zhao, Y.,Zhang, H.,Hu, J.,Cang, H.,Xu, S.,Gu, L. Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function. Biochem.J. 2012 448 201 211 4EQA 22931054 Crystal structure of PA1844 in complex with PA1845 from Pseudomonas aeruginosa PAO1 2012-04-18 2012-09-12 Shang, G.,Liu, X.,Lu, D.,Zhang, J.,Li, N.,Zhu, C.,Liu, S.,Yu, Q.,Zhao, Y.,Zhang, H.,Hu, J.,Cang, H.,Xu, S.,Gu, L. Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function. Biochem.J. 2012 448 201 211 3TN4 Crystal structure of GkaP mutant G209D from Geobacillus kaustophilus HTA426 2011-09-01 2012-09-19 An, J.,Zhang, Z.,Zhang, Y.,Feng, Y.,Wu, G. Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides to be published 0 0 0 0 4FLN 22961982 Crystal structure of plant protease Deg2 2012-06-15 2012-09-19 Sun, R.,Fan, H.,Gao, F.,Lin, Y.,Zhang, L.,Gong, W.,Liu, L. Crystal structure of Arabidopsis deg2 protein reveals an internal PDZ ligand locking the hexameric resting state. J.Biol.Chem. 2012 287 37564 37569 4FVK 23012237 Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus 2012-06-29 2012-09-19 Li, Q.,Sun, X.M.,Li, Z.X.,Liu, Y.,Vavricka, C.J.,Qi, J.X.,Gao, G.F. Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus Proc.Natl.Acad.Sci.USA 2012 109 18897 18902 3TYH Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae 2011-09-26 2012-09-26 Chen, W.J.,Wang, H.F.,Zhou, C.J.,Ye, D.R.,Huang, J.,Tan, X.S.,Zhong, W.Q. Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae To be Published 0 0 0 0 4G84 22958643 Crystal structure of human HisRS 2012-07-21 2012-09-26 Xu, Z.,Wei, Z.,Zhou, J.J.,Ye, F.,Lo, W.S.,Wang, F.,Lau, C.F.,Wu, J.,Nangle, L.A.,Chiang, K.P.,Yang, X.L.,Zhang, M.,Schimmel, P. Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing. Structure 2012 20 1470 1477 4G85 22958643 Crystal structure of human HisRS 2012-07-21 2012-09-26 Xu, Z.,Wei, Z.,Zhou, J.J.,Ye, F.,Lo, W.S.,Wang, F.,Lau, C.F.,Wu, J.,Nangle, L.A.,Chiang, K.P.,Yang, X.L.,Zhang, M.,Schimmel, P. Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing. Structure 2012 20 1470 1477 4EGX 22863567 Crystal structure of KIF1A CC1-FHA tandem 2012-04-02 2012-10-03 Huo, L.,Yue, Y.,Ren, J.,Yu, J.,Liu, J.,Yu, Y.,Ye, F.,Xu, T.,Zhang, M.,Feng, W. The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A Structure 2012 20 1550 1561 4EGX 22863567 Crystal structure of KIF1A CC1-FHA tandem 2012-04-02 2012-10-03 Huo, L.,Yue, Y.,Ren, J.,Yu, J.,Liu, J.,Yu, Y.,Ye, F.,Xu, T.,Zhang, M.,Feng, W. The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A Structure 2012 20 1550 1561 4EJQ 22863567 Crystal structure of KIF1A C-CC1-FHA 2012-04-06 2012-10-03 Huo, L.,Yue, Y.,Ren, J.,Yu, J.,Liu, J.,Yu, Y.,Ye, F.,Xu, T.,Zhang, M.,Feng, W. The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A Structure 2012 20 1550 1561 4FHZ 22987200 Crystal structure of a carboxyl esterase at 2.0 angstrom resolution 2012-06-07 2012-10-03 Ma, J.,Wu, L.,Guo, F.,Gu, J.,Tang, X.,Jiang, L.,Liu, J.,Zhou, J.,Yu, H. Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution. Appl.Microbiol.Biotechnol. 2013 97 4897 4906 4FTW 22987200 Crystal structure of a carboxyl esterase N110C/L145H at 2.3 angstrom resolution 2012-06-28 2012-10-03 Ma, J.,Wu, L.,Guo, F.,Gu, J.,Tang, X.,Jiang, L.,Liu, J.,Zhou, J.,Yu, H. Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution. Appl.Microbiol.Biotechnol. 2013 97 4897 4906 4GG4 23022487 Crystal structure of the TAL effector dHax3 bound to specific DNA-RNA hybrid 2012-08-05 2012-10-03 Yin, P.,Deng, D.,Yan, C.,Pan, X.J.,Xi, J.J.,Yan, N.,Shi, Y. Specific DNA-RNA hybrid recognition by TAL effectors Cell Rep 2012 2 707 713 4GG5 22985853 Crystal structure of CMET in complex with novel inhibitor 2012-08-05 2012-10-03 Wu, K.,Ai, J.,Liu, Q.,Chen, T.,Zhao, A.,Peng, X.,Wang, Y.,Ji, Y.,Yao, Q.,Xu, Y.,Geng, M.,Zhang, A. Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors. Bioorg.Med.Chem.Lett. 2012 22 6368 6372 4GG7 22985853 Crystal structure of cMET in complex with novel inhibitor 2012-08-06 2012-10-03 Wu, K.,Ai, J.,Liu, Q.,Chen, T.,Zhao, A.,Peng, X.,Wang, Y.,Ji, Y.,Yao, Q.,Xu, Y.,Geng, M.,Zhang, A. Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors. Bioorg.Med.Chem.Lett. 2012 22 6368 6372 4GJP Crystal structure of the TAL effector dHax3 bound to dsDNA containing repetitive methyl-CpG 2012-08-10 2012-10-03 Yan, N.,Deng, D.,Yan, C.Y.,Yin, P.,Pan, X.J.,Shi, Y.G. Crystal structure of a protein complex To be Published 0 0 0 0 4GJR Crystal structure of the TAL effector dHax3 bound to methylated dsDNA 2012-08-10 2012-10-03 Yan, N.,Deng, D.,Yan, C.Y.,Yin, P.,Pan, X.J.,Shi, Y.G. Crystal structure of a protein complex To be Published 0 0 0 0 4H5X 23135290 human Plk1-PBD with a glycerol bound at the phophopeptide binding site 2012-09-19 2012-10-03 Yin, Z.,Song, Y.,Rehse, P.H. Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic Acs Chem.Biol. 2013 8 303 308 4H71 23135290 Human Plk1-PBD in complex with Poloxime ((E)-4-(hydroxyimino)-2-isopropyl-5-methylcyclohexa-2,5-dienone) 2012-09-19 2012-10-03 Yin, Z.,Song, Y.,Rehse, P.H. Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic Acs Chem.Biol. 2013 8 303 308 4H75 23077255 Crystal structure of human Spindlin1 in complex with a histone H3K4(me3) peptide 2012-09-20 2012-10-03 Yang, N.,Wang, W.,Wang, Y.,Wang, M.,Zhao, Q.,Rao, Z.,Zhu, B.,Xu, R.M. Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1. Proc.Natl.Acad.Sci.USA 2012 109 17954 17959 3UST 22764321 Structure of BmNPV ORF075 (p33) 2011-11-23 2012-10-10 Hou, Y.,Xia, Q.,Yuan, Y.A. Crystal structure of Bombyx mori nucleopolyhedrovirus ORF75 reveals a pseudo-dimer of thiol oxidase domains with a putative substrate-binding pocket J.Gen.Virol. 2012 93 2142 2151 3VNB 22771475 Structural insights into small RNA sorting and mRNA binding by Arabidopsis Ago domains 2012-01-11 2012-10-10 Zha, X.,Xia, Q.,Yuan, Y.A. Structural insights into small RNA sorting and mRNA target binding by Arabidopsis Argonaute Mid domains Febs Lett. 2012 586 3200 3207 4ES4 23002140 Crystal structure of YdiV and FlhD complex 2012-04-22 2012-10-10 Li, B.,Li, N.,Wang, F.,Guo, L.,Huang, Y.,Liu, X.,Wei, T.,Zhu, D.,Liu, C.,Pan, H.,Xu, S.,Wang, H.W.,Gu, L. Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility Nucleic Acids Res. 2012 40 11073 11085 4GJT 23202587 complex structure of nectin-4 bound to MV-H 2012-08-10 2012-10-10 Zhang, X.,Lu, G.,Qi, J.,Li, Y.,He, Y.,Xu, X.,Shi, J.,Zhang, C.W.,Yan, J.,Gao, G.F. Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4 Nat.Struct.Mol.Biol. 2013 20 67 72 4H86 Crystal structure of Ahp1 from Saccharomyces cerevisiae in reduced form 2012-09-21 2012-10-10 Liu, M.,Wang, F.,Qiu, R.,Wu, T.,Gu, S.,Tang, R.,Ji, C. Crystal structure of Ahp1 from Saccharomyces cerevisiae in reduced form To be Published 0 0 0 0 3UTN 22587783 Crystal structure of Tum1 protein from Saccharomyces cerevisiae 2011-11-26 2012-10-17 Qiu, R.,Wang, F.,Liu, M.,Lou, T.,Ji, C. Crystal structure of the Tum1 protein from the yeast Saccharomyces cerevisiae. Protein Pept.Lett. 2012 19 1139 1143 4EKG 22978415 Crystal Structure of DOT1L in Complex with EPZ003696 2012-04-09 2012-10-17 Basavapathruni, A.,Jin, L.,Daigle, S.R.,Majer, C.R.,Therkelsen, C.A.,Wigle, T.J.,Kuntz, K.W.,Chesworth, R.,Pollock, R.M.,Scott, M.P.,Moyer, M.P.,Richon, V.M.,Copeland, R.A.,Olhava, E.J. Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des. 2012 80 971 980 4EKI 22978415 Crystal Structure of DOT1L in complex with EPZ004777 2012-04-09 2012-10-17 Basavapathruni, A.,Jin, L.,Daigle, S.R.,Majer, C.R.,Therkelsen, C.A.,Wigle, T.J.,Kuntz, K.W.,Chesworth, R.,Pollock, R.M.,Scott, M.P.,Moyer, M.P.,Richon, V.M.,Copeland, R.A.,Olhava, E.J. Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des. 2012 80 971 980 4GBZ 23075985 The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-glucose 2012-07-28 2012-10-17 Sun, L.,Zeng, X.,Yan, C.,Sun, X.,Gong, X.,Rao, Y.,Yan, N. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature 2012 490 361 366 4GC0 23075985 The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to 6-bromo-6-deoxy-D-glucose 2012-07-28 2012-10-17 Sun, L.,Zeng, X.,Yan, C.,Sun, X.,Gong, X.,Rao, Y.,Yan, N. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature 2012 490 361 366 4G6G 23086143 Crystal structure of NDH with TRT 2012-07-19 2012-10-24 Feng, Y.,Li, W.,Li, J.,Wang, J.,Ge, J.,Xu, D.,Liu, Y.,Wu, K.,Zeng, Q.,Wu, J.W.,Tian, C.,Zhou, B.,Yang, M. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature 2012 491 478 482 4G6H 23086143 Crystal structure of NDH with NADH 2012-07-19 2012-10-24 Feng, Y.,Li, W.,Li, J.,Wang, J.,Ge, J.,Xu, D.,Liu, Y.,Wu, K.,Zeng, Q.,Wu, J.W.,Tian, C.,Zhou, B.,Yang, M. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature 2012 491 478 482 4G73 23086143 Crystal structure of NDH with NADH and Quinone 2012-07-19 2012-10-24 Feng, Y.,Li, W.,Li, J.,Wang, J.,Ge, J.,Xu, D.,Liu, Y.,Wu, K.,Zeng, Q.,Wu, J.W.,Tian, C.,Zhou, B.,Yang, M. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature 2012 491 478 482 4G74 23086143 Crystal structure of NDH with Quinone 2012-07-19 2012-10-24 Feng, Y.,Li, W.,Li, J.,Wang, J.,Ge, J.,Xu, D.,Liu, Y.,Wu, K.,Zeng, Q.,Wu, J.W.,Tian, C.,Zhou, B.,Yang, M. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature 2012 491 478 482 3T9N 23074248 Crystal structure of a membrane protein 2011-08-03 2012-10-31 Zhang, X.,Wang, J.,Feng, Y.,Ge, J.,Li, W.,Sun, W.,Iscla, I.,Yu, J.,Blount, P.,Li, Y.,Yang, M. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance Proc.Natl.Acad.Sci.USA 2012 109 18180 18185 3UDC 23074248 Crystal structure of a membrane protein 2011-10-28 2012-10-31 Zhang, X.,Wang, J.,Feng, Y.,Ge, J.,Li, W.,Sun, W.,Iscla, I.,Yu, J.,Blount, P.,Li, Y.,Yang, M. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance Proc.Natl.Acad.Sci.USA 2012 109 18180 18185 3UIU Crystal structure of Apo-PKR kinase domain 2011-11-06 2012-11-07 Li, F.,Li, S.,Yang, X.,Shen, Y.,Zhang, T. Crystal structure of Apo-PKR kinase domain TO BE PUBLISHED 0 0 0 0 4HGA 23142979 Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX 2012-10-07 2012-11-07 Liu, C.P.,Xiong, C.Y.,Wang, M.Z.,Yu, Z.L.,Yang, N.,Chen, P.,Zhang, Z.G.,Li, G.H.,Xu, R.M. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat.Struct.Mol.Biol. 2012 19 1287 1292 4GY5 23161542 Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with Histone H3K9me3 2012-09-05 2012-11-14 Cheng, J.,Yang, Y.,Fang, J.,Xiao, J.,Zhu, T.,Chen, F.,Wang, P.,Li, Z.,Yang, H.,Xu, Y. Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein J.Biol.Chem. 2013 288 1329 1339 4H0N 23103599 Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant 2012-09-09 2012-11-14 Li, S.,Du, J.,Yang, H.,Yin, J.,Ding, J.,Zhong, J. Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J Mol Cell Biol 2013 5 64 66 3ULZ Crystal structure of apo BAK1 2011-11-11 2012-11-21 Lou, Z.Y.,Yan, L.M.,Ma, Y.Y. Structural basis for BAK1 activation To be Published 0 0 0 0 3UQP 23181502 Crystal structure of Bace1 with its inhibitor 2011-11-21 2012-11-21 Liu, Y.,Zhang, W.,Li, L.,Salvador, L.A.,Chen, T.T.,Chen, W.Y.,Felsenstein, K.M.,Ladd, T.B.,Price, A.R.,Golde, T.E.,He, J.,Xu, Y.C.,Li, Y.,Luesch, H. Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem. 2012 55 10749 10765 3UQR 23181502 Crystal structure of BACE1 with its inhibitor 2011-11-21 2012-11-21 Liu, Y.,Zhang, W.,Li, L.,Salvador, L.A.,Chen, T.T.,Chen, W.Y.,Felsenstein, K.M.,Ladd, T.B.,Price, A.R.,Golde, T.E.,He, J.,Xu, Y.C.,Li, Y.,Luesch, H. Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem. 2012 55 10749 10765 3UQU Crystal structure of BACE1 with its inhibitor 2011-11-21 2012-11-21 Xu, Y.C.,Chen, W.Y.,Chen, T.T. Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD simulations to be published 0 0 0 0 3UQW Crystal structure of BACE1 with its inhibitor 2011-11-21 2012-11-21 Xu, Y.C.,Chen, W.Y.,Chen, T.T. Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD simulations to be published 0 0 0 0 3UQX Crystal structure of BACE1 with its inhibitor 2011-11-21 2012-11-21 Xu, Y.C.,Chen, W.Y.,Chen, T.T. Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD simulations to be published 0 0 0 0 4FIU 22993148 The structure of hemagglutinin of H16 subtype influenza virus with V327G mutation 2012-06-11 2012-11-21 Lu, X.,Shi, Y.,Gao, F.,Xiao, H.,Wang, M.,Qi, J.,Gao, G.F. Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage. J.Virol. 2012 86 12861 12870 4HCP 23175788 crystal structure of Burkholderia pseudomallei effector protein chbp in complex with nedd8 2012-10-01 2012-11-21 Yao, Q.,Cui, J.,Wang, J.,Li, T.,Wan, X.,Luo, T.,Gong, Y.N.,Xu, Y.,Huang, N.,Shao, F. Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis. Proc.Natl.Acad.Sci.USA 2012 109 20395 20400 4DBF 23046410 Crystal structures of Cg1458 2012-01-15 2012-11-28 Ran, T.,Gao, Y.,Marsh, M.,Zhu, W.,Wang, M.,Mao, X.,Xu, L.,Xu, D.,Wang, W. Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for FAH family. Biochem.J. 2013 449 51 60 4DBH 23046410 Crystal structure of Cg1458 with inhibitor 2012-01-15 2012-11-28 Ran, T.,Gao, Y.,Marsh, M.,Zhu, W.,Wang, M.,Mao, X.,Xu, L.,Xu, D.,Wang, W. Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for FAH family. Biochem.J. 2013 449 51 60 4EUE 23050861 Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase in complex with NADH 2012-04-25 2012-11-28 Hu, K.,Zhao, M.,Zhang, T.,Zha, M.,Zhong, C.,Jiang, Y.,Ding, J. Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J. 2013 449 79 89 4EUF 23050861 Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase in complex with NAD 2012-04-25 2012-11-28 Hu, K.,Zhao, M.,Zhang, T.,Zha, M.,Zhong, C.,Jiang, Y.,Ding, J. Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J. 2013 449 79 89 4EUH 23050861 Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase apo form 2012-04-25 2012-11-28 Hu, K.,Zhao, M.,Zhang, T.,Zha, M.,Zhong, C.,Jiang, Y.,Ding, J. Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J. 2013 449 79 89 4FBG 23050861 Crystal structure of Treponema denticola trans-2-enoyl-CoA reductase in complex with NAD 2012-05-23 2012-11-28 Hu, K.,Zhao, M.,Zhang, T.,Zha, M.,Zhong, C.,Jiang, Y.,Ding, J. Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J. 2013 449 79 89 4FTX 23123112 Crystal structure of Ego3 homodimer 2012-06-28 2012-11-28 Zhang, T.,Peli-Gulli, M.P.,Yang, H.,De Virgilio, C.,Ding, J. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Structure 2012 20 2151 2160 4FTX 23123112 Crystal structure of Ego3 homodimer 2012-06-28 2012-11-28 Zhang, T.,Peli-Gulli, M.P.,Yang, H.,De Virgilio, C.,Ding, J. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Structure 2012 20 2151 2160 4FUW 23123112 Crystal structure of Ego3 mutant 2012-06-28 2012-11-28 Zhang, T.,Peli-Gulli, M.P.,Yang, H.,De Virgilio, C.,Ding, J. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Structure 2012 20 2151 2160 4FUW 23123112 Crystal structure of Ego3 mutant 2012-06-28 2012-11-28 Zhang, T.,Peli-Gulli, M.P.,Yang, H.,De Virgilio, C.,Ding, J. Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1. Structure 2012 20 2151 2160 4GHU 23150880 Crystal structure of TRAF3/Cardif 2012-08-08 2012-11-28 Zhang, P.,Reichardt, A.,Liang, H.,Aliyari, R.,Cheng, D.,Wang, Y.,Xu, F.,Cheng, G.,Liu, Y. Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5 Sci.Signal. 2012 5 0 0 4HXJ 23169783 Crystal structure of SH3:RGT complex 2012-11-11 2012-11-28 Xiao, R.,Xi, X.D.,Chen, Z.,Chen, S.J.,Meng, G. Structural framework of c-Src activation by integrin beta 3 Blood 2013 121 700 706 3VSZ 22960181 Crystal structure of Ct1,3Gal43A in complex with galactan 2012-05-18 2012-12-05 Jiang, D.,Fan, J.,Wang, X.,Zhao, Y.,Huang, B.,Liu, J.,Zhang, X.C. Crystal structure of 1,3Gal43A, an exo-beta-1,3-galactanase from Clostridium thermocellum J.Struct.Biol. 2012 180 447 457 3VT0 22960181 Crystal structure of Ct1,3Gal43A in complex with lactose 2012-05-18 2012-12-05 Jiang, D.,Fan, J.,Wang, X.,Zhao, Y.,Huang, B.,Liu, J.,Zhang, X.C. Crystal structure of 1,3Gal43A, an exo-beta-1,3-galactanase from Clostridium thermocellum J.Struct.Biol. 2012 180 447 457 3VT1 22960181 Crystal structure of Ct1,3Gal43A in complex with galactose 2012-05-18 2012-12-05 Jiang, D.,Fan, J.,Wang, X.,Zhao, Y.,Huang, B.,Liu, J.,Zhang, X.C. Crystal structure of 1,3Gal43A, an exo-beta-1,3-galactanase from Clostridium thermocellum J.Struct.Biol. 2012 180 447 457 3VT2 22960181 Crystal structure of Ct1,3Gal43A in complex with isopropy-beta-D-thiogalactoside 2012-05-18 2012-12-05 Jiang, D.,Fan, J.,Wang, X.,Zhao, Y.,Huang, B.,Liu, J.,Zhang, X.C. Crystal structure of 1,3Gal43A, an exo-beta-1,3-galactanase from Clostridium thermocellum J.Struct.Biol. 2012 180 447 457 4FZ4 23184929 Crystal structure of HP0197-18kd 2012-07-06 2012-12-05 Yuan, Z.Z.,Yan, X.J.,Zhang, A.D.,Chen, B.,Shen, Y.Q.,Jin, M.L. Molecular mechanism by which surface antigen HP0197 mediates host cell attachment in the pathogenic bacteria Streptococcus suis J.Biol.Chem. 2013 288 956 963 4FZQ 23184929 Crystal structure of HP0197-G5 2012-07-07 2012-12-05 Yuan, Z.Z.,Yan, X.J.,Zhang, A.D.,Chen, B.,Shen, Y.Q.,Jin, M.L. Molecular mechanism by which surface antigen HP0197 mediates host cell attachment in the pathogenic bacteria Streptococcus suis J.Biol.Chem. 2013 288 956 963 4HPZ 23147789 Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region 2012-10-25 2012-12-05 Gao, H.,Wu, X.,Chai, J.,Han, Z. Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region Cell Res. 2012 22 1716 1720 3V53 23190262 Crystal structure of human RBM25 2011-12-16 2012-12-12 Gong, D.S.,Yang, F.,Li, F.,Qian, D.,Wu, M.,Shao, Z.,Wu, M.,Wu, J.,Shi, Y. Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region Biochem.J. 2013 450 85 94 4HKF 23128673 Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA 2012-10-15 2012-12-12 Li, W.,Zhong, C.,Li, L.,Sun, B.,Wang, W.,Xu, S.,Zhang, T.,Wang, C.,Bao, L.,Ding, J. Molecular basis of the acetyltransferase activity of MEC-17 towards alpha- tubulin Cell Res. 2012 22 1707 1711 3VDU 23019218 Structure of recombination mediator protein RecRK21G mutant 2012-01-06 2012-12-19 Tang, Q.,Gao, P.,Liu, Y.P.,Gao, A.,An, X.M.,Liu, S.,Yan, X.X.,Liang, D.C. RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNA Nucleic Acids Res. 2012 40 11115 11125 4HYG 23254940 Structure of a presenilin family intramembrane aspartate protease in C222 space group 2012-11-13 2012-12-19 Li, X.,Dang, S.,Yan, C.,Gong, X.,Wang, J.,Shi, Y. Structure of a presenilin family intramembrane aspartate protease Nature 2013 493 56 61 4H0W 23256035 Bismuth bound human serum transferrin 2012-09-10 2012-12-26 Yang, N.,Zhang, H.,Wang, M.,Hao, Q.,Sun, H. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep 2012 2 999 999 4I16 22880103 Crystal structure of CARMA1 CARD 2012-11-20 2012-12-26 Li, S.,Yang, X.,Shao, J.,Shen, Y. Structural insights into the assembly of CARMA1 and BCL10 Plos One 2012 7 0 0 4I16 22880103 Crystal structure of CARMA1 CARD 2012-11-20 2012-12-26 Li, S.,Yang, X.,Shao, J.,Shen, Y. Structural insights into the assembly of CARMA1 and BCL10 Plos One 2012 7 0 0 3VAX 22570733 Crystal structure of DndA from streptomyces lividans 2011-12-30 2013-01-02 Chen, F.,Zhang, Z.,Lin, K.,Qian, T.,Zhang, Y.,You, D.,He, X.,Wang, Z.,Liang, J.,Deng, Z.,Wu, G. Crystal structure of the cysteine desulfurase DndA from Streptomyces lividans which is involved in DNA phosphorothioation Plos One 2012 7 0 0 3VAY 23695255 Crystal structure of 2-Haloacid Dehalogenase from Pseudomonas syringae pv. Tomato DC3000 2011-12-30 2013-01-02 Hou, Z.,Zhang, H.,Li, M.,Chang, W. Structure of 2-haloacid dehalogenase from Pseudomonas syringae pv. tomato DC3000 Acta Crystallogr.,Sect.D 2013 69 1108 1114 4DQN 22868765 Crystal structure of the branched-chain aminotransferase from Streptococcus mutans 2012-02-16 2013-01-02 Ruan, J.,Hu, J.,Yin, A.H.,Wu, W.Q.,Cong, X.Z.,Feng, X.T.,Li, S.T. Structure of the branched-chain aminotransferase from Streptococcus mutans Acta Crystallogr.,Sect.D 2012 68 996 1002 4GND 23269674 Crystal Structure of NSD3 tandem PHD5-C5HCH domains 2012-08-17 2013-01-02 He, C.,Li, F.,Zhang, J.,Wu, J.,Shi, Y. The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition. J.Biol.Chem. 2013 288 4692 4703 4GNE 23269674 Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-7 2012-08-17 2013-01-02 He, C.,Li, F.,Zhang, J.,Wu, J.,Shi, Y. The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition. J.Biol.Chem. 2013 288 4692 4703 4GNF 23269674 Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-15 2012-08-17 2013-01-02 He, C.,Li, F.,Zhang, J.,Wu, J.,Shi, Y. The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition. J.Biol.Chem. 2013 288 4692 4703 4GNG 23269674 Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3K9me3 peptide 2012-08-17 2013-01-02 He, C.,Li, F.,Zhang, J.,Wu, J.,Shi, Y. The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition. J.Biol.Chem. 2013 288 4692 4703 4HBL 23271738 Crystal structure of AbfR of Staphylococcus epidermidis 2012-09-28 2013-01-02 Liu, X.,Sun, X.,Wu, Y.,Xie, C.,Zhang, W.,Wang, D.,Chen, X.,Qu, D.,Gan, J.,Chen, H.,Jiang, H.,Lan, L.,Yang, C.G. Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis. J.Biol.Chem. 2013 288 3739 3752 3TLK Crystal structure of holo FepB 2011-08-30 2013-01-16 Li, N.,Gu, L. Crystal structure of holo FepB To be Published 0 0 0 0 4DV9 23181502 Crystal structure of BACE1 with its inhibitor 2012-02-23 2013-01-16 Liu, Y.,Zhang, W.,Li, L.,Salvador, L.A.,Chen, T.T.,Chen, W.Y.,Felsenstein, K.M.,Ladd, T.B.,Price, A.R.,Golde, T.E.,He, J.,Xu, Y.C.,Li, Y.,Luesch, H. Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem. 2012 55 10749 10765 4DVA 23016918 The crystal structure of human urokinase-type plasminogen activator catalytic domain 2012-02-23 2013-01-16 Jiang, L.,Botkjaer, K.A.,Andersen, L.M.,Yuan, C.,Andreasen, P.A.,Huang, M. Rezymogenation of active urokinase induced by an inhibitory antibody Biochem.J. 2013 449 161 166 4DVF 23181502 Crystal structure of BACE1 with its inhibitor 2012-02-23 2013-01-16 Liu, Y.,Zhang, W.,Li, L.,Salvador, L.A.,Chen, T.T.,Chen, W.Y.,Felsenstein, K.M.,Ladd, T.B.,Price, A.R.,Golde, T.E.,He, J.,Xu, Y.C.,Li, Y.,Luesch, H. Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem. 2012 55 10749 10765 4DW2 23016918 The crystal structure of uPA in complex with the Fab fragment of mAb-112 2012-02-24 2013-01-16 Jiang, L.,Botkjaer, K.A.,Andersen, L.M.,Yuan, C.,Andreasen, P.A.,Huang, M. Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem.J. 2013 449 161 166 4FGX 23181502 Crystal structure of bace1 with novel inhibitor 2012-06-05 2013-01-16 Liu, Y.,Zhang, W.,Li, L.,Salvador, L.A.,Chen, T.,Chen, W.,Felsenstein, K.M.,Ladd, T.B.,Price, A.R.,Golde, T.E.,He, J.,Xu, Y.,Li, Y.,Luesch, H. Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem. 2012 55 10749 10765 4FWF 23266887 Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic 2012-07-01 2013-01-16 Zhang, Q.,Qi, S.,Xu, M.,Yu, L.,Tao, Y.,Deng, Z.,Wu, W.,Li, J.,Chen, Z.,Wong, J. Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res. 2013 23 225 241 4G8B 23275166 Crystal structures of N-acyl homoserine lactonase AidH S102G mutant complexed with N-hexanoyl homoserine lactone 2012-07-23 2013-01-16 Gao, A.,Mei, G.Y.,Liu, S.,Wang, P.,Tang, Q.,Liu, Y.P.,Wen, H.,An, X.M.,Zhang, L.Q.,Yan, X.X.,Liang, D.C. High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase Acta Crystallogr.,Sect.D 2013 69 82 91 4G8C 23275166 Crystal structures of N-acyl homoserine lactonase AidH E219G mutant complexed with N-hexanoyl homoserine 2012-07-23 2013-01-16 Gao, A.,Mei, G.Y.,Liu, S.,Wang, P.,Tang, Q.,Liu, Y.P.,Wen, H.,An, X.M.,Zhang, L.Q.,Yan, X.X.,Liang, D.C. High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase Acta Crystallogr.,Sect.D 2013 69 82 91 4G9E 23275166 Crystal structures of N-acyl homoserine lactonase AidH complexed with N-butanoyl homoserine 2012-07-23 2013-01-16 Gao, A.,Mei, G.Y.,Liu, S.,Wang, P.,Tang, Q.,Liu, Y.P.,Wen, H.,An, X.M.,Zhang, L.Q.,Yan, X.X.,Liang, D.C. High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase Acta Crystallogr.,Sect.D 2013 69 82 91 4GA7 23269243 Crystal structure of human serpinB1 mutant 2012-07-25 2013-01-16 Wang, L.,Li, Q.,Wu, L.,Liu, S.,Zhang, Y.,Yang, X.,Zhu, P.,Zhang, H.,Zhang, K.,Lou, J.,Liu, P.,Tong, L.,Sun, F.,Fan, Z. Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol. 2013 190 1319 1330 4GU1 23260659 Crystal structure of LSD2 2012-08-29 2013-01-16 Fang, R.,Chen, F.,Dong, Z.,Hu, D.,Barbera, A.J.,Clark, E.A.,Fang, J.,Yang, Y.,Mei, P.,Rutenberg, M.,Li, Z.,Zhang, Y.,Xu, Y.,Yang, H.,Wang, P.,Simon, M.D.,Zhou, Q.,Li, J.,Marynick, M.P.,Li, X.,Lu, H.,Kaiser, U.B.,Kingston, R.E.,Xu, Y.,Shi, Y.G. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell 2013 49 558 570 4GUR 23260659 Crystal structure of LSD2-NPAC with H3 in space group P21 2012-08-29 2013-01-16 Fang, R.,Chen, F.,Dong, Z.,Hu, D.,Barbera, A.J.,Clark, E.A.,Fang, J.,Yang, Y.,Mei, P.,Rutenberg, M.,Li, Z.,Zhang, Y.,Xu, Y.,Yang, H.,Wang, P.,Simon, M.D.,Zhou, Q.,Li, J.,Marynick, M.P.,Li, X.,Lu, H.,Kaiser, U.B.,Kingston, R.E.,Xu, Y.,Shi, Y.G. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell 2013 49 558 570 4GUS 23260659 Crystal structure of LSD2-NPAC with H3 in space group P3221 2012-08-29 2013-01-16 Fang, R.,Chen, F.,Dong, Z.,Hu, D.,Barbera, A.J.,Clark, E.A.,Fang, J.,Yang, Y.,Mei, P.,Rutenberg, M.,Li, Z.,Zhang, Y.,Xu, Y.,Yang, H.,Wang, P.,Simon, M.D.,Zhou, Q.,Li, J.,Marynick, M.P.,Li, X.,Lu, H.,Kaiser, U.B.,Kingston, R.E.,Xu, Y.,Shi, Y.G. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell 2013 49 558 570 4GUT 23260659 Crystal structure of LSD2-NPAC 2012-08-29 2013-01-16 Fang, R.,Chen, F.,Dong, Z.,Hu, D.,Barbera, A.J.,Clark, E.A.,Fang, J.,Yang, Y.,Mei, P.,Rutenberg, M.,Li, Z.,Zhang, Y.,Xu, Y.,Yang, H.,Wang, P.,Simon, M.D.,Zhou, Q.,Li, J.,Marynick, M.P.,Li, X.,Lu, H.,Kaiser, U.B.,Kingston, R.E.,Xu, Y.,Shi, Y.G. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell 2013 49 558 570 4GUU 23260659 Crystal structure of LSD2-NPAC with tranylcypromine 2012-08-29 2013-01-16 Fang, R.,Chen, F.,Dong, Z.,Hu, D.,Barbera, A.J.,Clark, E.A.,Fang, J.,Yang, Y.,Mei, P.,Rutenberg, M.,Li, Z.,Zhang, Y.,Xu, Y.,Yang, H.,Wang, P.,Simon, M.D.,Zhou, Q.,Li, J.,Marynick, M.P.,Li, X.,Lu, H.,Kaiser, U.B.,Kingston, R.E.,Xu, Y.,Shi, Y.G. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell 2013 49 558 570 4FG8 23028635 Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-315 in complex with ATP 2012-06-04 2013-01-23 Zha, M.,Zhong, C.,Ou, Y.,Han, L.,Wang, J.,Ding, J. Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI. Plos One 2012 7 0 0 4FGB 23028635 Crystal structure of human calcium/calmodulin-dependent protein kinase I apo form 2012-06-04 2013-01-23 Zha, M.,Zhong, C.,Ou, Y.,Han, L.,Wang, J.,Ding, J. Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI. Plos One 2012 7 0 0 4G2V 23318951 Structure complex of LGN binding with FRMPD1 2012-07-13 2013-01-23 Pan, Z.,Shang, Y.,Jia, M.,Zhang, L.,Xia, C.,Zhang, M.,Wang, W.,Wen, W. Structural and biochemical characterization of the interaction between LGN and Frmpd1 J.Mol.Biol. 2013 425 1039 1049 4G2V 23318951 Structure complex of LGN binding with FRMPD1 2012-07-13 2013-01-23 Pan, Z.,Shang, Y.,Jia, M.,Zhang, L.,Xia, C.,Zhang, M.,Wang, W.,Wen, W. Structural and biochemical characterization of the interaction between LGN and Frmpd1 J.Mol.Biol. 2013 425 1039 1049 4GKF 23370277 Crystal structure and characterization of Cmr5 protein from Pyrococcus furiosus 2012-08-11 2013-01-23 Park, J.H.,Sun, J.,Park, S.Y.,Hwang, H.J.,Park, M.Y.,Shin, M.,Kim, J.S. Crystal structure of Cmr5 from Pyrococcus furiosus and its functional implications Febs Lett. 2013 587 562 568 4IHA 23381136 Crystal structure of rice DWARF14 (D14) in complex with a GR24 hydrolysis intermediate 2012-12-18 2013-01-23 Zhao, L.H.,Zhou, X.E.,Wu, Z.S.,Yi, W.,Xu, Y.,Li, S.,Xu, T.H.,Liu, Y.,Chen, R.Z.,Kovach, A.,Kang, Y.,Hou, L.,He, Y.,Xie, C.,Song, W.,Zhong, D.,Xu, Y.,Wang, Y.,Li, J.,Zhang, C.,Melcher, K.,Xu, H.E. Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res. 2013 23 436 439 3VB2 Crystal Structure of the Reduced Form of MarR from E.coli 2011-12-30 2013-01-30 Lou, H.,Zhu, R.,Hao, Z. The reduced form of MarR structure To be Published 0 0 0 0 4E4H Crystal structure of Histone Demethylase NO66 2012-03-13 2013-01-30 Tao, Y.,Wu, M.,Sinha, K.M.,Zang, J. tructural Basis for Tetramerization-dependent Gene Repression by Histone Demethylase NO66 To be Published 0 0 0 0 4EGT 23341770 Crystal structure of major capsid protein P domain from rabbit hemorrhagic disease virus 2012-04-01 2013-01-30 Wang, X.,Xu, F.,Liu, J.,Gao, B.,Liu, Y.,Zhai, Y.,Ma, J.,Zhang, K.,Baker, T.S.,Schulten, K.,Zheng, D.,Pang, H.,Sun, F. Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography. Plos Pathog. 2013 9 0 0 4FWI 23385461 Crystal structure of the nucleotide-binding domain of a dipeptide ABC transporter 2012-07-01 2013-01-30 Li, X.,Zhuo, W.,Yu, J.,Ge, J.,Gu, J.,Feng, Y.,Yang, M.,Wang, L.,Wang, N. Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain Acta Crystallogr.,Sect.D 2013 69 256 265 4IH9 23381136 Crystal structure of rice DWARF14 (D14) 2012-12-18 2013-01-30 Zhao, L.H.,Zhou, X.E.,Wu, Z.S.,Yi, W.,Xu, Y.,Li, S.,Xu, T.H.,Liu, Y.,Chen, R.Z.,Kovach, A.,Kang, Y.,Hou, L.,He, Y.,Xie, C.,Song, W.,Zhong, D.,Xu, Y.,Wang, Y.,Li, J.,Zhang, C.,Melcher, K.,Xu, H.E. Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res. 2013 23 436 439 3UT3 A novel PAI-I inhibitor and its structural mechanism 2011-11-25 2013-02-06 Lin, Z.H.,Hong, Z.B.,Shi, X.L.,Hu, L.H.,Andreasen, P.A.,Huang, M.D. A novel PAI-I inhibitor and its structural mechanism To be Published 0 0 0 0 3VPY 23313986 Crystal structure of Arabidopsis DDL FHA domain 2012-03-15 2013-02-06 Machida, S.,Yuan, A.Y. Crystal Structure of Arabidopsis thaliana Dawdle Forkhead-Associated Domain reveals a conserved phospho-threonine recognition cleft for Dicer-like1 binding. Mol Plant 2013 0 0 0 4F1R 23281037 Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginos 2012-05-07 2013-02-06 Wei, Y.,Zhang, H.,Gao, Z.Q.,Xu, J.H.,Liu, Q.S.,Dong, Y.H. Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa. Iubmb Life 2013 65 50 57 3VYX 23361462 Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase (DHX9) 2012-10-05 2013-02-13 Fu, Q.,Yuan, Y.A. Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9). Nucleic Acids Res. 2013 41 3457 3470 4DON Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon 2012-02-09 2013-02-13 Xiong, B.,Cao, D.Y.,Chen, W.Y.,Chen, T.T.,Xu, Y.C.,Shen, J.K. Brd4 Bromodomain 1 complex with a fragment 3,4-Dihydro-3-methyl-2(1H)-quinazolinon To be Published 0 0 0 0 4DOY 24470304 Crystal structure of Dibenzothiophene desulfurization enzyme C 2012-02-12 2013-02-13 Liu, S.,Zhang, C.,Su, T.,Wei, T.,Zhu, D.,Wang, K.,Huang, Y.,Dong, Y.,Yin, K.,Xu, S.,Xu, P.,Gu, L. Crystal structure of DszC from Rhodococcus sp. XP at 1.79 angstrom Proteins 2014 82 1708 1720 4DOY 24470304 Crystal structure of Dibenzothiophene desulfurization enzyme C 2012-02-12 2013-02-13 Liu, S.,Zhang, C.,Su, T.,Wei, T.,Zhu, D.,Wang, K.,Huang, Y.,Dong, Y.,Yin, K.,Xu, S.,Xu, P.,Gu, L. Crystal structure of DszC from Rhodococcus sp. XP at 1.79 angstrom Proteins 2014 82 1708 1720 4GU0 23357850 Crystal structure of LSD2 with H3 2012-08-29 2013-02-13 Chen, F.,Yang, H.,Dong, Z.,Fang, J.,Wang, P.,Zhu, T.,Gong, W.,Fang, R.,Shi, Y.G.,Li, Z.,Xu, Y. Structural insight into substrate recognition by histone demethylase LSD2/KDM1b Cell Res. 2013 23 306 309 4HSU 23357850 Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 2012-10-30 2013-02-13 Chen, F.,Yang, H.,Dong, Z.,Fang, J.,Wang, P.,Zhu, T.,Gong, W.,Fang, R.,Shi, Y.G.,Li, Z.,Xu, Y. Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Res. 2013 23 306 309 4J0U Crystal structure of IFIT5/ISG58 2013-01-31 2013-02-13 Liu, Y.,Liang, H.,Feng, F.,Yuan, L.,Wang, Y.E.,Crowley, C.,Lv, Z.,Li, J.,Zeng, S.,Cheng, G. Crystal Structure of IFIT5 To be Published 0 0 0 0 4EGN 23135838 The X-ray crystal structure of CYP199A4 in complex with veratric acid 2012-03-31 2013-02-20 Bell, S.G.,Zhou, R.M.,Yang, W.,Tan, A.B.H.,Gentleman, A.S.,Wong, L.-L.,Zhou, W. Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering Chemistry 2012 18 16677 16688 4H53 23422659 Influenza N2-Tyr406Asp neuraminidase in complex with beta-Neu5Ac 2012-09-18 2013-02-20 Vavricka, C.J.,Liu, Y.,Kiyota, H.,Sriwilaijaroen, N.,Qi, J.,Tanaka, K.,Wu, Y.,Li, Q.,Li, Y.,Yan, J.,Suzuki, Y.,Gao, G.F. Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors Nat Commun 2013 4 1491 1491 4FMM 23519406 Dimeric Sec14 family homolog 3 from Saccharomyces cerevisiae presents some novel features of structure that lead to a surprising ""dimer-monomer"" state change induced by substrate binding 2012-06-18 2013-02-27 Yuan, Y.,Zhao, W.,Wang, X.,Gao, Y.,Niu, L.,Teng, M. Dimeric Sfh3 has structural changes in its binding pocket that are associated with a dimer-monomer state transformation induced by substrate binding. Acta Crystallogr.,Sect.D 2013 69 313 323 3VPM Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant 2012-03-05 2013-03-06 Chen, X.,Xu, Z.,Liu, H.,Zhang, L.,Chen, B.,Zhu, L.,Yang, C.,Zhu, W.,Shao, J. Essential role of E106 in the proton-coupled electron transfer in human ribonucleotide reductase M2 subunit To be Published 0 0 0 0 3VPN Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant 2012-03-05 2013-03-06 Chen, X.,Xu, Z.,Liu, H.,Zhang, L.,Chen, B.,Zhu, L.,Yang, C.,Zhu, W.,Shao, J. Essential role of E106 in the proton-coupled electron transfer in human to be published 0 0 0 0 3VPO Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant 2012-03-05 2013-03-06 Chen, X.,Xu, Z.,Liu, H.,Zhang, L.,Chen, B.,Zhu, L.,Yang, C.,Zhu, W.,Shao, J. Essential role of E106 in the proton-coupled electron transfer in human to be published 0 0 0 0 4DZD Crystal structure of the CRISPR-associated protein Cas6e from Escherichia coli str. K-12 2012-03-01 2013-03-06 Wei, J.,Huang, G.,Wang, Y.,Gong, W. Crystal Structure of endoribonuclease Cas6e from Escherichia coli To be Published 0 0 0 0 4ENF 23436652 Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1) 2012-04-13 2013-03-06 Liu, Y.,Qin, K.,Meng, G.,Zhang, J.,Zhou, J.,Zhao, G.,Luo, M.,Zheng, X. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus J.Biol.Chem. 2013 288 11013 11023 4EQK 23436652 Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP 2012-04-19 2013-03-06 Liu, Y.,Qin, K.,Meng, G.,Zhang, J.,Zhou, J.,Zhao, G.,Luo, M.,Zheng, X. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus J.Biol.Chem. 2013 288 11013 11023 4ES5 23436652 Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Bar-headed Gs/Qinghai/15c/2005 (h5n1) with bound m7GTP 2012-04-22 2013-03-06 Liu, Y.,Qin, K.,Meng, G.,Zhang, J.,Zhou, J.,Zhao, G.,Luo, M.,Zheng, X. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus J.Biol.Chem. 2013 288 11013 11023 4FZA 23434407 Crystal structure of MST4-MO25 complex 2012-07-06 2013-03-06 Shi, Z.,Jiao, S.,Zhang, Z.,Ma, M.,Zhang, Z.,Chen, C.,Wang, K.,Wang, H.,Wang, W.,Zhang, L.,Zhao, Y.,Zhou, Z. Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism Structure 2013 21 449 461 4FZD 23434407 Crystal structure of MST4-MO25 complex with WSF motif 2012-07-06 2013-03-06 Shi, Z.,Jiao, S.,Zhang, Z.,Ma, M.,Zhang, Z.,Chen, C.,Wang, K.,Wang, H.,Wang, W.,Zhang, L.,Zhao, Y.,Zhou, Z. Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism Structure 2013 21 449 461 4FZF 23434407 Crystal structure of MST4-MO25 complex with DKI 2012-07-06 2013-03-06 Shi, Z.,Jiao, S.,Zhang, Z.,Ma, M.,Zhang, Z.,Chen, C.,Wang, K.,Wang, H.,Wang, W.,Zhang, L.,Zhao, Y.,Zhou, Z. Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism Structure 2013 21 449 461 4IS5 23443661 Crystal Structure of the ligand-free inactive Matriptase 2013-01-16 2013-03-06 Zhao, B.,Yuan, C.,Li, R.,Qu, D.,Huang, M.,Ngo, J.C. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem. 2013 288 11155 11164 4ISL 23443661 Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1 2013-01-16 2013-03-06 Zhao, B.,Yuan, C.,Li, R.,Qu, D.,Huang, M.,Ngo, J.C. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem. 2013 288 11155 11164 4ISN 23443661 Crystal Structure of Matriptase in complex with its inhibitor HAI-1 2013-01-16 2013-03-06 Zhao, B.,Yuan, C.,Li, R.,Qu, D.,Huang, M.,Ngo, J.C. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem. 2013 288 11155 11164 4ISO 23443661 Crystal Structure of Matriptase in complex with its inhibitor HAI-1 2013-01-16 2013-03-06 Zhao, B.,Yuan, C.,Li, R.,Qu, D.,Huang, M.,Ngo, J.C. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem. 2013 288 11155 11164 4IVM 23467411 Structure of human protoporphyrinogen IX oxidase(R59G) 2013-01-23 2013-03-06 Wang, B.,Wen, X.,Qin, X.,Wang, Z.,Tan, Y.,Shen, Y.,Xi, Z. Quantitative structural insight into human variegate porphyria disease. J.Biol.Chem. 2013 288 11731 11740 4IVO 23467411 Structure of human protoporphyrinogen IX oxidase(R59Q) 2013-01-23 2013-03-06 Wang, B.,Wen, X.,Qin, X.,Wang, Z.,Tan, Y.,Shen, Y.,Xi, Z. Quantitative structural insight into human variegate porphyria disease. J.Biol.Chem. 2013 288 11731 11740 4E2A Crystal Structure of the Putative acetyltransferase from Streptococcus mutans 2012-03-08 2013-03-13 Li, G.L.,Nie, J.K.,Li, L.F.,Su, X.D. Crystal Structure of the Putative acetyltransferase from Streptococcus mutans To be Published 0 0 0 0 4FJQ 23438177 Crystal Structure of an alpha-Bisabolol synthase 2012-06-12 2013-03-13 Li, J.X.,Fang, X.,Zhao, Q.,Ruan, J.X.,Yang, C.Q.,Wang, L.J.,Miller, D.J.,Faraldos, J.A.,Allemann, R.K.,Chen, X.Y.,Zhang, P. Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency. Biochem.J. 2013 451 417 426 4GAX 23438177 Crystal Structure of an alpha-Bisabolol synthase mutant 2012-07-26 2013-03-13 Li, J.X.,Fang, X.,Zhao, Q.,Ruan, J.X.,Yang, C.Q.,Wang, L.J.,Miller, D.J.,Faraldos, J.A.,Allemann, R.K.,Chen, X.Y.,Zhang, P. Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency. Biochem.J. 2013 451 417 426 4GK0 23143872 Crystal structure of human Rev3-Rev7-Rev1 complex 2012-08-10 2013-03-13 Xie, W.,Yang, X.,Xu, M.,Jiang, T. Structural insights into the assembly of human translesion polymerase complexes Protein Cell 2012 3 864 874 4GK5 23143872 Crystal structure of human Rev3-Rev7-Rev1-Polkappa complex 2012-08-10 2013-03-13 Xie, W.,Yang, X.,Xu, M.,Jiang, T. Structural insights into the assembly of human translesion polymerase complexes Protein Cell 2012 3 864 874 4ITH 23473668 Crystal structure of RIP1 kinase in complex with necrostatin-1 analog 2013-01-18 2013-03-13 Xie, T.,Peng, W.,Liu, Y.,Yan, C.,Maki, J.,Degterev, A.,Yuan, J.,Shi, Y. Structural Basis of RIP1 Inhibition by Necrostatins. Structure 2013 21 493 499 4ITI 23473668 Crystal structure of RIP1 kinase in complex with necrostatin-3 analog 2013-01-18 2013-03-13 Xie, T.,Peng, W.,Liu, Y.,Yan, C.,Maki, J.,Degterev, A.,Yuan, J.,Shi, Y. Structural Basis of RIP1 Inhibition by Necrostatins. Structure 2013 21 493 499 4ITJ 23473668 Crystal structure of RIP1 kinase in complex with necrostatin-4 2013-01-18 2013-03-13 Xie, T.,Peng, W.,Liu, Y.,Yan, C.,Maki, J.,Degterev, A.,Yuan, J.,Shi, Y. Structural Basis of RIP1 Inhibition by Necrostatins. Structure 2013 21 493 499 4JDL 23844015 Crystal structure of native abscisic acid receptor PYL5 at 2.65 Angstrom 2013-02-25 2013-03-13 Zhang, X.,Jiang, L.,Wang, G.,Yu, L.,Zhang, Q.,Xin, Q.,Wu, W.,Gong, Z.,Chen, Z. Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR Plos One 2013 8 0 0 4E55 Crystal Structure of spacer removed cephalosporin acylase mutant 2012-03-14 2013-03-20 Yin, J.,Zhang, Z.,Wu, G.,Huang, X. Spacer shortened Cephalosporin acylase To be Published 0 0 0 0 4E56 Crystal Structure of spacer 8aa-shortened cephalosporin acylase mutant 2012-03-14 2013-03-20 Yin, J.,Zhang, Z.,Wu, G.,Huang, X. spacer shortened Cephalosporin acylase To be Published 0 0 0 0 4E57 Crystal Structure of spacer 6aa-shortened cephalosporin acylase mutant 2012-03-14 2013-03-20 Yin, J.,Zhang, Z.,Wu, G.,Huang, X. spacer shortened Cephalosporin acylase To be Published 0 0 0 0 4EJY 23246782 Structure of MBOgg1 in complex with high affinity DNA ligand 2012-04-08 2013-03-20 Yu, H.J.,Yang, M.Z.,Zhang, X.E.,Bi, L.J.,Jiang, T. Crystal structures of MBOgg1 in complex with two abasic DNA ligands J.Struct.Biol. 2013 181 252 263 4EJZ 23246782 Structure of MBOgg1 in complex with low affinity DNA ligand 2012-04-08 2013-03-20 Yu, H.J.,Yang, M.Z.,Zhang, X.E.,Bi, L.J.,Jiang, T. Crystal structures of MBOgg1 in complex with two abasic DNA ligands J.Struct.Biol. 2013 181 252 263 4FGY 23178929 Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity 2012-06-05 2013-03-20 Zheng, W.,Feng, X.,Qiu, L.,Pan, Z.,Wang, R.,Lin, S.,Hou, D.,Jin, L.,Li, Y. Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia 2013 56 401 411 4FZ3 23316803 Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin 2012-07-06 2013-03-20 Wu, J.,Zhang, D.,Chen, L.,Li, J.,Wang, J.,Ning, C.,Yu, N.,Zhao, F.,Chen, D.,Chen, X.,Chen, K.,Jiang, H.,Liu, H.,Liu, D. Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate J.Med.Chem. 2013 56 761 780 4IJX 23384440 Crystal structure of human Ap4A hydrolase E58A mutant complexed with DPO 2012-12-24 2013-03-20 Ge, H.,Chen, X.,Yang, W.,Niu, L.,Teng, M. Crystal structure of wild-type and mutant human Ap4A hydrolase. Biochem.Biophys.Res.Commun. 2013 432 16 21 4IP3 Complex structure of OspI and Ubc13 2013-01-09 2013-03-20 Fu, P.,Jin, M.,Zhang, X.,Xu, L.,Xia, Z.,Zhu, Y. Structure Analysis of Ubc13 Inactivation To be Published 0 0 0 0 4EAC 22796868 Crystal structure of mannonate dehydratase from Escherichia coli strain K12 2012-03-22 2013-03-27 Qiu, X.,Tao, Y.,Zhu, Y.,Yuan, Y.,Zhang, Y.,Liu, H.,Gao, Y.,Teng, M.,Niu, L. Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. J.Struct.Biol. 2012 180 327 334 4EAY 22796868 Crystal structures of mannonate dehydratase from Escherichia coli strain K12 complexed with D-mannonate 2012-03-23 2013-03-27 Qiu, X.,Tao, Y.,Zhu, Y.,Yuan, Y.,Zhang, Y.,Liu, H.,Gao, Y.,Teng, M.,Niu, L. Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. J.Struct.Biol. 2012 180 327 334 4HHY 23473053 Crystal structure of PARP catalytic domain in complex with novel inhibitors 2012-10-10 2013-03-27 Ye, N.,Chen, C.H.,Chen, T.,Song, Z.,He, J.X.,Huan, X.J.,Song, S.S.,Liu, Q.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.H.,Zhang, A. Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors. J.Med.Chem. 2013 56 2885 2903 4HHZ 23473053 Crystal structure of PARP catalytic domain in complex with novel inhibitors 2012-10-10 2013-03-27 Ye, N.,Chen, C.H.,Chen, T.,Song, Z.,He, J.X.,Huan, X.J.,Song, S.S.,Liu, Q.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.H.,Zhang, A. Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors. J.Med.Chem. 2013 56 2885 2903 4HKA 23333332 Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase in complex with HEME 2012-10-15 2013-03-27 Huang, W.,Gong, Z.,Li, J.,Ding, J. Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism. J.Struct.Biol. 2013 181 291 299 4I5S 23468592 Structure and function of sensor histidine kinase 2012-11-28 2013-03-27 Wang, C.,Sang, J.,Wang, J.,Su, M.,Downey, J.S.,Wu, Q.,Wang, S.,Cai, Y.,Xu, X.,Wu, J.,Senadheera, D.B.,Cvitkovitch, D.G.,Chen, L.,Goodman, S.D.,Han, A. Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains Plos Biol. 2013 11 0 0 3ZG6 23552949 The novel de-long chain fatty acid function of human sirt6 2012-12-15 2013-04-03 Jiang, H.,Khan, S.,Wang, Y.,Charron, G.,He, B.,Sebastian, C.,Du, J.,Kim, R.,Ge, E.,Mostoslavsky, R.,Hang, H.C.,Hao, Q.,Lin, H. Sirt6 Regulates Tnf-Alpha Secretion Through Hydrolysis of Long-Chain Fatty Acyl Lysine Nature 2013 496 110 0 4F45 Crystal structure of human CD38 E226Q mutant in complex with NAADP 2012-05-10 2013-04-03 Zhang, H.,Graeff, R.,Lee, H.C.,Hao, Q. Crystal Structures of Human CD38 in Complex with NAADP and ADPRP MESSENGER 2013 2 44 53 4F46 Crystal structure of wild type human CD38 in complex with NAADP and ADPRP 2012-05-10 2013-04-03 Zhang, H.,Graeff, R.,Lee, H.C.,Hao, Q. Crystal Structures of Human CD38 in Complex with NAADP and ADPRP MESSENGER 2013 2 44 53 4HXK 23530754 Brd4 Bromodomain 1 complex with 6,7-DIHYDROTHIENO[3,2-C]PYRIDIN-5(4H)-YL(1H-IMIDAZOL-1-YL)METHANONE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4HXL 23530754 Brd4 Bromodomain 1 complex with 3-CYCLOHEXYL-N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}PROPANAMIDE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4HXM 23530754 Brd4 Bromodomain 1 complex with N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}BUTANAMIDE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4HXN 23530754 Brd4 Bromodomain 1 complex with 4-(2-FLUOROPHENYL)-1,3-THIAZOL-2(3H)-ONE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4HXO 23530754 Brd4 Bromodomain 1 complex with 3-{[(3-METHYL-1,2-OXAZOL-5-YL)METHYL]SULFANYL}[1,2,4]TRIAZOLO[4,3-A]PYRIDINE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4HXP 23530754 Brd4 Bromodomain 1 complex with 4-(2-OXO-1,3-OXAZOLIDIN-3-YL)BENZAMIDE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4HXR 23530754 Brd4 Bromodomain 1 complex with N-[3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)PHENYL]THIOPHENE-2-SULFONAMIDE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4HXS 23530754 Brd4 Bromodomain 1 complex with N-[3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)PHENYL]-1-PHENYLMETHANESULFONAMIDE inhibitor 2012-11-12 2013-04-03 Zhao, L.,Cao, D.,Chen, T.,Wang, Y.,Miao, Z.,Xu, Y.,Chen, W.,Wang, X.,Li, Y.,Du, Z.,Xiong, B.,Li, J.,Xu, C.,Zhang, N.,He, J.,Shen, J. Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain. J.Med.Chem. 2013 56 3833 3851 4IGO 23357881 Histone H3 Lysine 4 Demethylating rice Rice JMJ703 in complex with alpha-KG 2012-12-17 2013-04-03 Chen, Q.,Chen, X.,Wang, Q.,Zhang, F.,Lou, Z.,Zhang, Q.,Zhou, D.X. Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet. 2013 9 0 0 4IGP 23357881 Histone H3 Lysine 4 Demethylating Rice JMJ703 apo enzyme 2012-12-17 2013-04-03 Chen, Q.,Chen, X.,Wang, Q.,Zhang, F.,Lou, Z.,Zhang, Q.,Zhou, D.X. Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet. 2013 9 0 0 4EKZ 22657537 Crystal structure of reduced hPDI (abb'xa') 2012-04-10 2013-04-10 Wang, C.,Li, W.,Ren, J.,Fang, J.,Ke, H.,Gong, W.,Feng, W.,Wang, C.-C. Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase Antioxid Redox Signal 2013 19 44 53 4EL1 22657537 Crystal structure of oxidized hPDI (abb'xa') 2012-04-10 2013-04-10 Wang, C.,Li, W.,Ren, J.,Fang, J.,Ke, H.,Gong, W.,Feng, W.,Wang, C.-C. Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase Antioxid Redox Signal 2013 19 44 53 4HK1 23545643 Crystal Structure of PCNA from Drosophila melanogaster 2012-10-14 2013-04-10 Wang, K.,Shi, Z.,Zhang, M.,Cheng, D. Structure of PCNA from Drosophila melanogaster. Acta Crystallogr.,Sect.F 2013 69 387 392 4IT8 A sperm whale myoglobin mutant L29H Mb with two distal histidines 2013-01-18 2013-04-10 Sun, M.-H.,Li, W.,Liu, J.-H.,Wen, G.-B.,Tan, X.-S.,Lin, Y.-W. Structural and nitrite reductase activity comparisons of myoglobins with one to three distal histidines. RSC Adv 2013 0 0 0 4J1J 23569220 Leanyer orthobunyavirus nucleoprotein-ssDNA complex 2013-02-01 2013-04-10 Niu, F.,Shaw, N.,Wang, Y.E.,Jiao, L.,Ding, W.,Li, X.,Zhu, P.,Upur, H.,Ouyang, S.,Cheng, G.,Liu, Z.J. Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation. Proc.Natl.Acad.Sci.USA 2013 110 9054 9059 3VRL Crystal structure of BMJ4 p24 capsid protein in complex with A10F9 Fab 2012-04-12 2013-04-17 Gu, Y.,Cao, F.,Li, S.,Yuan, Y.A.,Xia, N. Structure of the HIV-1 capsid protein p24 in complex with the broad-spectrum antibody A10F9 To be Published 0 0 0 0 4E5Y Structure of human FX protein, the key enzyme in the biosynthesis of GDP-L-fucose 2012-03-15 2013-04-17 Zhou, H.,He, J.H. Structure of human FX protein, the key enzyme in the biosynthesis of GDP-L-fucose To be Published 0 0 0 0 4ELO Ferric binding protein in apo form 1 2012-04-11 2013-04-17 Wang, Q.,Liu, X.Q.,Wang, X.Q. Crystal structure of the ferric binding protein A To be Published 0 0 0 0 4ELP Ferric binding protein in apo form 2 2012-04-11 2013-04-17 Wang, Q.,Liu, X.Q.,Wang, X.Q. Crystal structure of ferric binding protein A To be Published 0 0 0 0 4ELQ Ferric binding protein with carbonate 2012-04-11 2013-04-17 Wang, Q.,Liu, X.Q.,Wang, X.Q. Crystal structure of ferric binding protein A To be Published 0 0 0 0 4ELR Ferric binding protein with iron and carbonate 2012-04-11 2013-04-17 Wang, Q.,Liu, X.Q.,Wang, X.Q. Crystal structure of ferric binding protein A To be Published 0 0 0 0 4EMM 23625918 Crystal structure of Staphylococcus aureus ClpP in compact conformation 2012-04-12 2013-04-17 Ye, F.,Zhang, J.,Liu, H.,Hilgenfeld, R.,Zhang, R.,Kong, X.,Li, L.,Lu, J.,Zhang, X.,Li, D.,Jiang, H.,Yang, C.-G.,Luo, C. Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease J.Biol.Chem. 2013 288 17643 17653 4EMP 23625918 Crystal structure of the mutant of ClpP E137A from Staphylococcus aureus 2012-04-12 2013-04-17 Ye, F.,Zhang, J.,Liu, H.,Hilgenfeld, R.,Zhang, R.,Kong, X.,Li, L.,Lu, J.,Zhang, X.,Li, D.,Jiang, H.,Yang, C.-G.,Luo, C. Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease J.Biol.Chem. 2013 288 17643 17653 4GEH 23541896 Crystal structure of MST4 dimerization domain complex with PDCD10 2012-08-02 2013-04-17 Zhang, M.,Dong, L.,Shi, Z.,Jiao, S.,Zhang, Z.,Zhang, W.,Liu, G.,Chen, C.,Feng, M.,Hao, Q.,Wang, W.,Yin, M.,Zhao, Y.,Zhang, L.,Zhou, Z. Structural mechanism of CCM3 heterodimerization with GCKIII kinases Structure 2013 21 680 688 4HK4 Crystal structure of apo Tyrosine-tRNA ligase mutant protein 2012-10-15 2013-04-17 Yu, Y.,Zhou, Q.,Dong, J.,Li, J.,Xiaoxuan, L.,Mukherjee, A.,Ouyang, H.,Nilges, M.,Li, H.,Gao, F.,Gong, W.,Lu, Y.,Wang, J. Crystal structure of apo Tyrosine-tRNA ligase mutant protein To be Published 0 0 0 0 4HRI Crystal structure of HetR in complex with a 21-bp palindromic DNA at the upstream of the hetP promoter from Anabaena 2012-10-28 2013-04-17 Hu, H.X.,Jiang, Y.L.,Zhao, M.X.,Zhu, P.F.,Yang, X.Y.,Wen, B.,Zhang, Z.,Wu, Q.,Chen, Y.,Zhang, C.C.,Zhou, C.Z. Structural and biochemical analyses of Anabaena HetR reveal insights into its binding to DNA targets and the inhibitory hexapeptide ERGSGR To be Published 0 0 0 0 4HT8 23605038 Crystal structure of E coli Hfq bound to poly(A) A7 2012-11-01 2013-04-17 Wang, W.,Wang, L.,Wu, J.,Gong, Q.,Shi, Y. Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res. 2013 41 5938 5948 4HT9 23605038 Crystal structure of E coli Hfq bound to two RNAs 2012-11-01 2013-04-17 Wang, W.,Wang, L.,Wu, J.,Gong, Q.,Shi, Y. Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA. Nucleic Acids Res. 2013 41 5938 5948 4HUQ 23584589 Crystal Structure of a transporter 2012-11-03 2013-04-17 Xu, K.,Zhang, M.,Zhao, Q.,Yu, F.,Guo, H.,Wang, C.,He, F.,Ding, J.,Zhang, P. Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature 2013 497 268 271 4HUQ 23584589 Crystal Structure of a transporter 2012-11-03 2013-04-17 Xu, K.,Zhang, M.,Zhao, Q.,Yu, F.,Guo, H.,Wang, C.,He, F.,Ding, J.,Zhang, P. Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature 2013 497 268 271 4HZU 23584587 Structure of a bacterial energy-coupling factor transporter 2012-11-15 2013-04-17 Wang, T.,Fu, G.,Pan, X.,Wu, J.,Gong, X.,Wang, J.,Shi, Y. Structure of a bacterial energy-coupling factor transporter. Nature 2013 497 272 276 4IU8 23523348 Crystal structure of a membrane transporter (selenomethionine derivative) 2013-01-20 2013-04-17 Yan, H.,Huang, W.,Yan, C.,Gong, X.,Jiang, S.,Zhao, Y.,Wang, J.,Shi, Y. Structure and mechanism of a nitrate transporter. Cell Rep 2013 3 716 723 4IU9 23523348 Crystal structure of a membrane transporter 2013-01-20 2013-04-17 Yan, H.,Huang, W.,Yan, C.,Gong, X.,Jiang, S.,Zhao, Y.,Wang, J.,Shi, Y. Structure and mechanism of a nitrate transporter. Cell Rep 2013 3 716 723 4E8E Structural characterization of Bombyx mori glutathione transferase BmGSTD1 2012-03-20 2013-04-24 Tan, X.,Ma, X.X.,Hu, X.M.,Chen, Q.M.,Zhao, P.,Xia, Q.Y.,Zhou, C.Z. Structural characterization of Bombyx mori glutathione transferase BmGSTD1 To be Published 0 0 0 0 4E8H Structural of Bombyx mori glutathione transferase BmGSTD1 complex with GTT 2012-03-20 2013-04-24 Tan, X.,Ma, X.X.,Hu, X.M.,Chen, Q.M.,Zhao, P.,Xia, Q.Y.,Zhou, C.Z. Structural of Bombyx mori glutathione transferase BmGSTD1 complex with GTT To be Published 0 0 0 0 4E9A Structure of Peptide Deformylase form Helicobacter Pylori in complex with inhibitor 2012-03-20 2013-04-24 Cui, K.,Zhu, L.,Lu, W.,Huang, J. Identification of Novel Peptide Deformylase Inhibitors from Natural Products To be Published 0 0 0 0 4E9B Structure of Peptide Deformylase form Helicobacter Pylori in complex with actinonin 2012-03-20 2013-04-24 Cui, K.,Zhu, L.,Lu, W.,Huang, J. Identification of Novel Peptide Deformylase Inhibitors from Natural Products To be Published 0 0 0 0 4EQ2 24283193 Crystal Structure Analysis of Chicken Interferon Gamma Receptor Alpha Chain 2012-04-18 2013-04-24 Ping, Z.,Qi, J.,Sun, Y.,Lu, G.,Shi, Y.,Wang, X.,Gao, G.F.,Wang, M. Crystal structure of the interferon gamma receptor alpha chain from chicken reveals an undetected extra helix compared with the human counterparts. J.Interferon Cytokine Res. 2014 34 41 51 4EQ3 24283193 Crystal Structure Analysis of Selenomethionine (Se-Met) Substituted Chicken Interferon Gamma Receptor Alpha Chain 2012-04-18 2013-04-24 Ping, Z.,Qi, J.,Sun, Y.,Lu, G.,Shi, Y.,Wang, X.,Gao, G.F.,Wang, M. Crystal structure of the interferon gamma receptor alpha chain from chicken reveals an undetected extra helix compared with the human counterparts. J.Interferon Cytokine Res. 2014 34 41 51 4ES7 crystal structure of protein HC from Homo sapiens at 2 angstrom 2012-04-22 2013-04-24 Zhang, Y.L.,Gao, Z.Q.,Wang, D.Q.,Dong, Y.H. crystal structure of protein HC from Home sapiens at 2 angstrom To be Published 0 0 0 0 4GO1 23589368 Crystal Structure of full length transcription repressor LsrR from E. coli. 2012-08-17 2013-04-24 Wu, M.,Tao, Y.,Liu, X.,Zang, J. Structural Basis for Phosphorylated Autoinducer-2 Modulation of the Oligomerization State of the Global Transcription Regulator LsrR from Escherichia coli J.Biol.Chem. 2013 288 15878 15887 4HRV 23545639 Crystal Structure of Lipoprotein GNA1162 from Neisseria meningitidis 2012-10-28 2013-04-24 Cai, X.,Lu, J.,Wu, Z.,Yang, C.,Xu, H.,Lin, Z.,Shen, Y. Structure of Neisseria meningitidis lipoprotein GNA1162 Acta Crystallogr.,Sect.F 2013 69 362 368 4IKB Crystal structure of SNX11 PX domain 2012-12-26 2013-04-24 Xu, J.,Xu, T.,Liu, J. Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended PX Domain (PXe Domain) Critical for the Inhibition of Sorting Nexin 10 (SNX10) Induced Vacuolation to be published 0 0 0 0 4IKD Crystal structure of SNX11 PX domain 2012-12-26 2013-04-24 Xu, J.,Xu, T.,Liu, J. Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended PX Domain (PXe Domain) Critical for the Inhibition of Sorting Nexin 10 (SNX10) Induced Vacuolation to be published 0 0 0 0 4IPL 23580646 The crystal structure of 6-phospho-beta-glucosidase BglA-2 from Streptococcus pneumoniae 2013-01-10 2013-04-24 Yu, W.L.,Jiang, Y.L.,Pikis, A.,Cheng, W.,Bai, X.H.,Ren, Y.M.,Thompson, J.,Zhou, C.Z.,Chen, Y. Structural insights into the substrate specificity of a 6-phospho-&[beta]-glucosidase BglA-2 from Streptococcus pneumoniae TIGR4 J.Biol.Chem. 2013 288 14949 14958 4IPN 23580646 The complex structure of 6-phospho-beta-glucosidase BglA-2 with thiocellobiose-6P from Streptococcus pneumoniae 2013-01-10 2013-04-24 Yu, W.L.,Jiang, Y.L.,Pikis, A.,Cheng, W.,Bai, X.H.,Ren, Y.M.,Thompson, J.,Zhou, C.Z.,Chen, Y. Structural insights into the substrate specificity of a 6-phospho-&[beta]-glucosidase BglA-2 from Streptococcus pneumoniae TIGR4 J.Biol.Chem. 2013 288 14949 14958 4JSR 23570514 Crystal Structure of human SIRT3 with ELT inhibitor 11c [N-{2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl}-N'-ethylthiophene-2,5-dicarboxamide] 2013-03-22 2013-04-24 Disch, J.S.,Evindar, G.,Chiu, C.H.,Blum, C.A.,Dai, H.,Jin, L.,Schuman, E.,Lind, K.E.,Belyanskaya, S.L.,Deng, J.,Coppo, F.,Aquilani, L.,Graybill, T.L.,Cuozzo, J.W.,Lavu, S.,Mao, C.,Vlasuk, G.P.,Perni, R.B. Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3. J.Med.Chem. 2013 56 3666 3679 4JT9 23570514 Crystal Structure of human SIRT3 with ELT inhibitor 3 [14-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide] 2013-03-22 2013-04-24 Disch, J.S.,Evindar, G.,Chiu, C.H.,Blum, C.A.,Dai, H.,Jin, L.,Schuman, E.,Lind, K.E.,Belyanskaya, S.L.,Deng, J.,Coppo, F.,Aquilani, L.,Graybill, T.L.,Cuozzo, J.W.,Lavu, S.,Mao, C.,Vlasuk, G.P.,Perni, R.B. Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3. J.Med.Chem. 2013 56 3666 3679 4IC5 23633592 Crystal structure of Deg5 2012-12-10 2013-05-01 Sun, W.,Gao, F.,Fan, H.,Shan, X.,Sun, R.,Liu, L.,Gong, W. The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases Acta Crystallogr.,Sect.D 2013 69 830 837 4IC6 23633592 Crystal structure of Deg8 2012-12-10 2013-05-01 Sun, W.,Gao, F.,Fan, H.,Shan, X.,Sun, R.,Liu, L.,Gong, W. The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases Acta Crystallogr.,Sect.D 2013 69 830 837 4JTV 23514882 Crystal structure of 2009 pandemic influenza virus hemagglutinin complexed with human receptor analogue LSTc 2013-03-24 2013-05-01 Zhang, W.,Shi, Y.,Qi, J.,Gao, F.,Li, Q.,Fan, Z.,Yan, J.,Gao, G.F. Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol. 2013 87 5949 5958 4JTX 23514882 Crystal structure of 2009 pandemic influenza virus hemagglutinin mutant D225E 2013-03-24 2013-05-01 Zhang, W.,Shi, Y.,Qi, J.,Gao, F.,Li, Q.,Fan, Z.,Yan, J.,Gao, G.F. Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol. 2013 87 5949 5958 4JU0 23514882 Crystal structure of 2009 pandemic influenza virus hemagglutinin mutant D225E complexed with human receptor analogue LSTc 2013-03-24 2013-05-01 Zhang, W.,Shi, Y.,Qi, J.,Gao, F.,Li, Q.,Fan, Z.,Yan, J.,Gao, G.F. Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol. 2013 87 5949 5958 4JUG 23514882 Crystal structure of 1918 pandemic influenza virus hemagglutinin mutant D225G 2013-03-24 2013-05-01 Zhang, W.,Shi, Y.,Qi, J.,Gao, F.,Li, Q.,Fan, Z.,Yan, J.,Gao, G.F. Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol. 2013 87 5949 5958 4JUH 23514882 Crystal structure of 1918 pandemic influenza virus hemagglutinin mutant D225G complexed with avian receptor analogue LSTa 2013-03-24 2013-05-01 Zhang, W.,Shi, Y.,Qi, J.,Gao, F.,Li, Q.,Fan, Z.,Yan, J.,Gao, G.F. Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol. 2013 87 5949 5958 4JUJ 23514882 Crystal structure of 1918 pandemic influenza virus hemagglutinin mutant D225G complexed with human receptor analogue LSTc 2013-03-25 2013-05-01 Zhang, W.,Shi, Y.,Qi, J.,Gao, F.,Li, Q.,Fan, Z.,Yan, J.,Gao, G.F. Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution J.Virol. 2013 87 5949 5958 4K2C 23592780 HSA Ligand Free 2013-04-08 2013-05-01 Wang, Y.,Yu, H.,Shi, X.,Luo, Z.,Lin, D.,Huang, M. Structural mechanism of ring-opening reaction of glucose by human serum albumin. J. Biol. Chem. 2013 288 15980 15987 4FQ0 23614777 Crystal structure of FliG-FliM complex from H. pylori 2012-06-24 2013-05-08 Lam, K.H.,Lam, W.W.L.,Wong, J.Y.,Chan, L.C.,Kotaka, M.,Ling, T.K.W.,Jin, D.Y.,Ottemann, K.M.,Au, S.W.N. Structural basis of FliG-FliM interaction in Helicobacter pylori Mol.Microbiol. 2013 88 798 812 4GC8 23614777 Crystal structure of FliM middle domain from H. pylori 2012-07-30 2013-05-08 Lam, K.H.,Lam, W.W.L.,Wong, J.Y.,Chan, L.C.,Kotaka, M.,Ling, T.K.W.,Jin, D.Y.,Ottemann, K.M.,Au, S.W.N. Structural basis of FliG-FliM interaction in Helicobacter pylori Mol.Microbiol. 2013 88 798 812 4GXL 23386746 The crystal structure of Galectin-8 C-CRD in complex with NDP52 2012-09-04 2013-05-08 Li, S.,Wandel, M.P.,Li, F.,Liu, Z.,He, C.,Wu, J.,Shi, Y.,Randow, F. Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy Sci.Signal. 2013 6 0 0 4I42 23658663 E.coli. 1,4-dihydroxy-2-naphthoyl coenzyme A synthase (ecMenB) in complex with 1-hydroxy-2-naphthoyl-CoA 2012-11-27 2013-05-08 Sun, Y.,Song, H.,Li, J.,Li, Y.,Jiang, M.,Zhou, J.,Guo, Z. Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily Plos One 2013 8 0 0 4I4Z 23658663 Synechocystis sp. PCC 6803 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase (MenB) in complex with salicylyl-CoA 2012-11-28 2013-05-08 Sun, Y.,Song, H.,Li, J.,Li, Y.,Jiang, M.,Zhou, J.,Guo, Z. Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme a synthase from the crotonase fold superfamily Plos One 2013 8 0 0 4I52 23658663 scMenB im complex with 1-hydroxy-2-naphthoyl-CoA 2012-11-28 2013-05-08 Sun, Y.,Song, H.,Li, J.,Li, Y.,Jiang, M.,Zhou, J.,Guo, Z. Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme a synthase from the crotonase fold superfamily Plos One 2013 8 0 0 4I5T 23628156 Crystal structure of yeast Ap4A phosphorylase Apa2 2012-11-29 2013-05-08 Hou, W.T.,Li, W.Z.,Chen, Y.,Jiang, Y.L.,Zhou, C.Z. Structures of yeast Apa2 reveal catalytic insights into a canonical AP4A phosphorylase of the histidine triad superfamily J.Mol.Biol. 2013 425 2687 2698 4I5V 23628156 Crystal structure of yeast Ap4A phosphorylase Apa2 in complex with Ap4A 2012-11-29 2013-05-08 Hou, W.T.,Li, W.Z.,Chen, Y.,Jiang, Y.L.,Zhou, C.Z. Structures of yeast Apa2 reveal catalytic insights into a canonical AP4A phosphorylase of the histidine triad superfamily J.Mol.Biol. 2013 425 2687 2698 4I5W 23628156 Crystal structure of yeast Ap4A phosphorylase Apa2 in complex with AMP 2012-11-29 2013-05-08 Hou, W.T.,Li, W.Z.,Chen, Y.,Jiang, Y.L.,Zhou, C.Z. Structures of yeast Apa2 reveal catalytic insights into a canonical AP4A phosphorylase of the histidine triad superfamily J.Mol.Biol. 2013 425 2687 2698 4JVS 23588383 Crystal structure of LepB GAP domain from Legionella drancourtii in complex with Rab1-GDP and AlF3 2013-03-26 2013-05-08 Yu, Q.,Hu, L.,Yao, Q.,Zhu, Y.,Dong, N.,Wang, D.-C.,Shao, F. Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP Cell Res. 2013 23 775 787 4KFO 23617784 Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors 2013-04-27 2013-05-08 Zheng, X.,Bauer, P.,Baumeister, T.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Han, B.,Ho, Y.C.,Kley, N.,Lin, J.,Reynolds, D.J.,Sharma, G.,Smith, C.C.,Wang, Z.,Dragovich, P.S.,Oh, A.,Wang, W.,Zak, M.,Gunzner-Toste, J.,Zhao, G.,Yuen, P.W.,Bair, K.W. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem. 2013 56 4921 4937 4F44 Neurotrophin p75NTR intracellular domain 2012-05-10 2013-05-15 Qu, Q.,Jiang, T. Structural insights into the allosteric activation mechanism of p75NTR To be Published 0 0 0 0 4HY6 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1 2012-11-13 2013-05-15 Yang, M.,Li, J.,He, J.H. Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1 to be published 0 0 0 0 4F7K Crystal structure of Lac15 from a marine microbial metagenome 2012-05-16 2013-05-22 Ge, H.,Xiao, Y. Crystal structure of Lac15 from a marine microbial metagenome To be Published 0 0 0 0 4F8E 23509005 Crystal structure of human PRS1 D52H mutant 2012-05-17 2013-05-22 Chen, P.,Li, J.,Ma, J.,Teng, M.,Li, X. A small disturbance, but a serious disease: the possible mechanism of D52H-mutant of human PRS1 that causes gout Iubmb Life 2013 65 518 525 4J4S 23576501 Triple mutant SFTAVN 2013-02-07 2013-05-22 Jiao, L.,Ouyang, S.,Liang, M.,Niu, F.,Shaw, N.,Wu, W.,Ding, W.,Jin, C.,Peng, Y.,Zhu, Y.,Zhang, F.,Wang, T.,Li, C.,Zuo, X.,Luan, C.H.,Li, D.,Liu, Z.J. Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol. 2013 87 6829 6839 4J4U 23576501 Pentamer SFTSVN 2013-02-07 2013-05-22 Jiao, L.,Ouyang, S.,Liang, M.,Niu, F.,Shaw, N.,Wu, W.,Ding, W.,Jin, C.,Peng, Y.,Zhu, Y.,Zhang, F.,Wang, T.,Li, C.,Zuo, X.,Luan, C.H.,Li, D.,Liu, Z.J. Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol. 2013 87 6829 6839 4J4W 23576501 Crystal structure of BueVN 2013-02-07 2013-05-22 Jiao, L.,Ouyang, S.,Liang, M.,Niu, F.,Shaw, N.,Wu, W.,Ding, W.,Jin, C.,Peng, Y.,Zhu, Y.,Zhang, F.,Wang, T.,Li, C.,Zuo, X.,Luan, C.H.,Li, D.,Liu, Z.J. Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol. 2013 87 6829 6839 4K62 23641058 Structure of an avian influenza H5 hemagglutinin from the influenza virus A/Indonesia/5/2005 2013-04-15 2013-05-22 Zhang, W.,Shi, Y.,Lu, X.,Shu, Y.,Qi, J.,Gao, G.F. An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science 2013 340 1463 1467 4K63 23641058 Structure of an avian influenza H5 hemagglutinin from the influenza virus complexed with avian receptor analog LSTa 2013-04-15 2013-05-22 Zhang, W.,Shi, Y.,Lu, X.,Shu, Y.,Qi, J.,Gao, G.F. An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science 2013 340 1463 1467 4K65 23641058 Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005 2013-04-15 2013-05-22 Zhang, W.,Shi, Y.,Lu, X.,Shu, Y.,Qi, J.,Gao, G.F. An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science 2013 340 1463 1467 4K66 23641058 Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005 complexed with avian receptor analog LSTa 2013-04-15 2013-05-22 Zhang, W.,Shi, Y.,Lu, X.,Shu, Y.,Qi, J.,Gao, G.F. An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science 2013 340 1463 1467 4FCO Crystal structure of bace1 with its inhibitor 2012-05-25 2013-05-29 Xu, Y.C.,Chen, W.Y.,Chen, T.T.,Li, L. Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD simulations To be Published 2012 0 0 0 4HQ1 23147790 Crystal structure of an LRR protein with two solenoids 2012-10-25 2013-05-29 Liu, P.,Hu, Z.,Zhou, B.,Liu, S.,Chai, J. Crystal structure of an LRR protein with two solenoids Cell Res. 2013 23 303 305 4HWC 23695238 Structure of ATBAG1 2012-11-07 2013-05-29 Fang, S.,Li, L.,Cui, B.,Men, S.,Shen, Y.,Yang, X. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr.,Sect.D 2013 69 934 945 4HWD 23695238 Crystal structure of ATBAG2 2012-11-07 2013-05-29 Fang, S.,Li, L.,Cui, B.,Men, S.,Shen, Y.,Yang, X. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr.,Sect.D 2013 69 934 945 4HWF 23695238 Crystal structure of ATBAG3 2012-11-07 2013-05-29 Fang, S.,Li, L.,Cui, B.,Men, S.,Shen, Y.,Yang, X. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr.,Sect.D 2013 69 934 945 4HWH 23695238 Crystal structure of ATBAG4 2012-11-07 2013-05-29 Fang, S.,Li, L.,Cui, B.,Men, S.,Shen, Y.,Yang, X. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr.,Sect.D 2013 69 934 945 4HWI 23695238 Crystal structure of ATBAG1 in complex with HSP70 2012-11-07 2013-05-29 Fang, S.,Li, L.,Cui, B.,Men, S.,Shen, Y.,Yang, X. Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr.,Sect.D 2013 69 934 945 4FD3 Crystal structure of apo-formed ymtOAR1 2012-05-26 2013-06-05 Zhang, Y.,Gao, Y.,Ning, F.,Niu, L.,Teng, M. Crystal structure of apo-formed ymtOAR1 To be Published 0 0 0 0 4J0W 23509373 Structure of U3-55K 2013-01-31 2013-06-05 Zhang, L.,Lin, J.,Ye, K. Structural and functional analysis of the U3 snoRNA binding protein Rrp9. Rna 2013 19 701 711 4J0X 23509373 Structure of Rrp9 2013-01-31 2013-06-05 Zhang, L.,Lin, J.,Ye, K. Structural and functional analysis of the U3 snoRNA binding protein Rrp9. Rna 2013 19 701 711 4JHR 23665171 An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs 2013-03-05 2013-06-05 Pan, Z.,Zhu, J.,Shang, Y.,Wei, Z.,Jia, M.,Xia, C.,Wen, W.,Wang, W.,Zhang, M. An autoinhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs Structure 2013 21 1007 1017 4K1I 23531861 Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding 2013-04-05 2013-06-05 Wu, Y.,Qin, G.,Gao, F.,Liu, Y.,Vavricka, C.J.,Qi, J.,Jiang, H.,Yu, K.,Gao, G.F. Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding Sci Rep 2013 3 1551 1551 4K1J 23531861 Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding 2013-04-05 2013-06-05 Wu, Y.,Qin, G.,Gao, F.,Liu, Y.,Vavricka, C.J.,Qi, J.,Jiang, H.,Yu, K.,Gao, G.F. Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding Sci Rep 2013 3 1551 1551 4K1K 23531861 Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding 2013-04-05 2013-06-05 Wu, Y.,Qin, G.,Gao, F.,Liu, Y.,Vavricka, C.J.,Qi, J.,Jiang, H.,Yu, K.,Gao, G.F. Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding Sci Rep 2013 3 1551 1551 4KLY 24100316 Crystal structure of a blue-light absorbing proteorhodopsin mutant D97N from HOT75 2013-05-07 2013-06-05 Ran, T.,Ozorowski, G.,Gao, Y.,Sineshchekov, O.A.,Wang, W.,Spudich, J.L.,Luecke, H. Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes. Acta Crystallogr.,Sect.D 2013 69 1965 1980 4KLY 24100316 Crystal structure of a blue-light absorbing proteorhodopsin mutant D97N from HOT75 2013-05-07 2013-06-05 Ran, T.,Ozorowski, G.,Gao, Y.,Sineshchekov, O.A.,Wang, W.,Spudich, J.L.,Luecke, H. Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes. Acta Crystallogr.,Sect.D 2013 69 1965 1980 4KNF 24100316 Crystal structure of a blue-light absorbing proteorhodopsin double-mutant D97N/Q105L from HOT75 2013-05-09 2013-06-05 Ran, T.,Ozorowski, G.,Gao, Y.,Sineshchekov, O.A.,Wang, W.,Spudich, J.L.,Luecke, H. Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes. Acta Crystallogr.,Sect.D 2013 69 1965 1980 4KNF 24100316 Crystal structure of a blue-light absorbing proteorhodopsin double-mutant D97N/Q105L from HOT75 2013-05-09 2013-06-05 Ran, T.,Ozorowski, G.,Gao, Y.,Sineshchekov, O.A.,Wang, W.,Spudich, J.L.,Luecke, H. Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes. Acta Crystallogr.,Sect.D 2013 69 1965 1980 4J4Y 23576501 Triple mutant GraVN 2013-02-07 2013-06-12 Jiao, L.,Ouyang, S.,Liang, M.,Niu, F.,Shaw, N.,Wu, W.,Ding, W.,Jin, C.,Peng, Y.,Zhu, Y.,Zhang, F.,Wang, T.,Li, C.,Zuo, X.,Luan, C.H.,Li, D.,Liu, Z.J. Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol. 2013 87 6829 6839 3VYP 23588382 Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase LdtMt2-N140 adduct with meropenem 2012-09-30 2013-06-19 Li, W.J.,Li, D.F.,Hu, Y.L.,Zhang, X.E.,Bi, L.J.,Wang, D.C. Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis Cell Res. 2013 23 728 731 4ISS 23754281 SeMet-substituted Kluyveromyces lactis Allophanate Hydrolase 2013-01-17 2013-06-19 Fan, C.,Li, Z.,Yin, H.,Xiang, S. Structure and function of allophanate hydrolase. J.Biol.Chem. 2013 288 21422 21432 4IST 23754281 S177A Kluyveromyces lactis Allophanate Hydrolase 2013-01-17 2013-06-19 Fan, C.,Li, Z.,Yin, H.,Xiang, S. Structure and function of allophanate hydrolase. J.Biol.Chem. 2013 288 21422 21432 4JDZ 23549613 Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands 2013-02-25 2013-06-19 Wang, X.,Ge, J.,Liu, B.,Hu, Y.,Yang, M. Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands Protein Cell 2013 4 277 285 4JE0 23549613 Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands 2013-02-25 2013-06-19 Wang, X.,Ge, J.,Liu, B.,Hu, Y.,Yang, M. Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands Protein Cell 2013 4 277 285 4JND 23760267 Structure of a C.elegans sex determining protein 2013-03-15 2013-06-19 Zhang, Y.,Zhao, H.,Wang, J.,Ge, J.,Li, Y.,Gu, J.,Li, P.,Feng, Y.,Yang, M. Structural insight into Caenorhabditis elegans sex-determining protein FEM-2. J.Biol.Chem. 2013 288 22058 22066 4KT1 23756652 Complex of R-spondin 1 with LGR4 extracellular domain 2013-05-19 2013-06-19 Wang, D.L.,Huang, B.,Zhang, S.,Yu, X.,Wu, W.,Wang, X.Q. Structural basis for R-spondin recognition by LGR4/5/6 receptors Genes Dev. 2013 27 1339 1344 4F2L 23765502 Structure of a regulatory domain of AMPK 2012-05-08 2013-06-26 Chen, L.,Xin, F.J.,Wang, J.,Hu, J.,Zhang, Y.Y.,Wan, S.,Cao, L.S.,Lu, C.,Li, P.,Yan, S.F.,Neumann, D.,Schlattner, U.,Xia, B.,Wang, Z.X.,Wu, J.W. Conserved regulatory elements in AMPK Nature 2013 498 0 0 4FQB crystal structure of toxic effector Tse1 in complex with immune protein Tsi1 2012-06-25 2013-06-26 Li, L.,Zhang, W.,Wang, T. structural basis of Tse1 in complex with Tsi1 To be Published 0 0 0 0 4FYP 23166664 Crystal Structure of Plant Vegetative Storage Protein 2012-07-05 2013-06-26 Chen, Y.,Wei, J.,Wang, M.,Shi, Z.,Gong, W.,Zhang, M. The crystal structure of Arabidopsis VSP1 reveals the plant class C-like phosphatase structure of the DDDD superfamily of phosphohydrolases Plos One 2012 7 0 0 4G2W 23137303 Crystal structure of PDE5A in complex with its inhibitor 2012-07-13 2013-06-26 Wang, G.,Liu, Z.,Chen, T.T.,Wang, Z.,Yang, H.,Zheng, M.,Ren, J.,Tian, G.,Yang, X.,Li, L.,Li, J.,Suo, J.,Zhang, R.,Jiang, X.,Terrett, N.K.,Shen, J.,Xu, Y.C.,Jiang, H. Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J.Med.Chem. 2012 55 10540 10550 4G2Y 23137303 Crystal structure of PDE5A complexed with its inhibitor 2012-07-13 2013-06-26 Wang, G.,Liu, Z.,Chen, T.T.,Wang, Z.,Yang, H.,Zheng, M.,Ren, J.,Tian, G.,Yang, X.,Li, L.,Li, J.,Suo, J.,Zhang, R.,Jiang, X.,Terrett, N.K.,Shen, J.,Xu, Y.C.,Jiang, H. Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J.Med.Chem. 2012 55 10540 10550 4GHQ 23633597 Crystal structure of EV71 3C proteinase 2012-08-08 2013-06-26 Wu, C.,Cai, Q.,Chen, C.,Li, N.,Peng, X.,Cai, Y.,Yin, K.,Chen, X.,Wang, X.,Zhang, R.,Liu, L.,Chen, S.,Li, J.,Lin, T. Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir Acta Crystallogr.,Sect.D 2013 69 866 871 4HBK 23734964 Structure of the Aldose Reductase from Schistosoma japonicum 2012-09-28 2013-06-26 Liu, J.,Dyer, D.,Cheng, J.,Wang, J.,Wang, S.,Yang, Z.,Wang, X.,Hu, W. Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds. Parasit Vectors 2013 6 162 162 4JBJ 23567559 Structural mimicry for functional antagonism 2013-02-19 2013-06-26 Ru, H.,Ni, X.,Zhao, L.,Crowley, C.,Ding, W.,Hung, L.-W.,Shaw, N.,Cheng, G.,Liu, Z.-J. Structural basis for termination of AIM2-mediated signaling by p202 Cell Res. 2013 23 855 858 4JL3 23803605 Crystal structure of ms6564-dna complex 2013-03-12 2013-06-26 Yang, S.,Gao, Z.,Li, T.,Yang, M.,Zhang, T.,Dong, Y.,He, Z.G. Structural basis for interaction between Mycobacterium smegmatis Ms6564, a TetR family master regulator, and its target DNA. J.Biol.Chem. 2013 288 23687 23695 4KA3 23722236 Structure of MAP kinase in complex with a docking peptide 2013-04-22 2013-06-26 Xin, F.J.,Wu, J.W. Crystal structure of the p38 alpha MAP kinase in complex with a docking peptide from TAB1 Sci China Life Sci 2013 56 653 660 4FZX 23771145 Exonuclease X in complex with 3' overhanging duplex DNA 2012-07-08 2013-07-03 Wang, T.,Sun, H.L.,Cheng, F.,Zhang, X.E.,Bi, L.,Jiang, T. Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease Nucleic Acids Res. 2013 41 7556 7565 4FZY 23771145 Exonuclease X in complex with 12bp blunt-ended dsDNA 2012-07-08 2013-07-03 Wang, T.,Sun, H.L.,Cheng, F.,Zhang, X.E.,Bi, L.,Jiang, T. Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease Nucleic Acids Res. 2013 41 7556 7565 4FZZ 23771145 Exonuclease X in complex with 5' overhanging duplex DNA 2012-07-08 2013-07-03 Wang, T.,Sun, H.L.,Cheng, F.,Zhang, X.E.,Bi, L.,Jiang, T. Recognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonuclease Nucleic Acids Res. 2013 41 7556 7565 4KPS 23760233 Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6 2013-05-14 2013-07-03 Lu, X.,Qi, J.,Shi, Y.,Wang, M.,Smith, D.F.,Heimburg-Molinaro, J.,Zhang, Y.,Paulson, J.C.,Xiao, H.,Gao, G.F. Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6 J.Virol. 2013 87 9077 9085 3WB8 23798443 Crystal Structure of MyoVa-GTD 2013-05-13 2013-07-10 Wei, Z.,Liu, X.,Yu, C.,Zhang, M. Structural basis of cargo recognitions for class V myosins Proc.Natl.Acad.Sci.USA 2013 110 11314 11319 4G03 High-resolution Crystal Structural Variance Analysis between Recombinant and Wild-type Human Serum Albumin 2012-07-09 2013-07-10 Cao, H.L.,Yin, D.C. High-resolution Crystal Structural Variance Analysis between Recombinant and Wild-type Human Serum Albumin To be Published 0 0 0 0 4G04 High-resolution Crystal Structural Variance Analysis between Recombinant and Wild-type Human Serum Albumin 2012-07-09 2013-07-10 Cao, H.L.,Yin, D.C. High-resolution Crystal Structural Variance Analysis between Recombinant and Wild-type Human Serum Albumin To be Published 0 0 0 0 4GB0 23255131 Crystal Structure of the RING domain of RNF168 2012-07-26 2013-07-10 Zhang, X.Q.,Chen, J.,Wu, M.,Wu, H.,Arokiaraj, A.W.,Wang, C.L.,Zhang, W.,Tao, Y.,Huen, M.S.,Zang, J.Y. Structural basis for role of ring finger protein RNF168 RING domain Cell Cycle 2013 12 312 321 4H32 23434510 The crystal structure of the hemagglutinin H17 derived the bat influenza A virus 2012-09-13 2013-07-10 Sun, X.,Shi, Y.,Lu, X.,He, J.,Gao, F.,Yan, J.,Qi, J.,Gao, G.F. Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism. Cell Rep 2013 3 769 778 4K6N 23818518 Crystal structure of yeast 4-amino-4-deoxychorismate lyase 2013-04-16 2013-07-10 Dai, Y.-N.,Chi, C.-B.,Zhou, K.,Cheng, W.,Jiang, Y.-L.,Ren, Y.-M.,Ruan, K.,Chen, Y.,Zhou, C.-Z. Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase J.Biol.Chem. 2013 288 22985 22992 4KP3 23798443 Crystal Structure of MyoVa-GTD in Complex with Two Cargos 2013-05-13 2013-07-10 Wei, Z.,Liu, X.,Yu, C.,Zhang, M. Structural basis of cargo recognitions for class V myosins Proc.Natl.Acad.Sci.USA 2013 110 11314 11319 4KQZ 23831647 structure of the receptor binding domain (RBD) of MERS-CoV spike 2013-05-15 2013-07-10 Lu, G.,Hu, Y.,Wang, Q.,Qi, J.,Gao, F.,Li, Y.,Zhang, Y.,Zhang, W.,Yuan, Y.,Bao, J.,Zhang, B.,Shi, Y.,Yan, J.,Gao, G.F. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 2013 500 227 231 4KR0 23831647 Complex structure of MERS-CoV spike RBD bound to CD26 2013-05-15 2013-07-10 Lu, G.,Hu, Y.,Wang, Q.,Qi, J.,Gao, F.,Li, Y.,Zhang, Y.,Zhang, W.,Yuan, Y.,Bao, J.,Zhang, B.,Shi, Y.,Yan, J.,Gao, G.F. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 2013 500 227 231 4FF5 23874703 Structure basis of a novel virulence factor GHIP a glycosyl hydrolase 25 of Streptococcus pneumoniae participating in host cell invasion 2012-05-31 2013-07-17 Niu, S.,Luo, M.,Tang, J.,Zhou, H.,Zhang, Y.,Min, X.,Cai, X.,Zhang, W.,Xu, W.,Li, D.,Ding, J.,Hu, Y.,Wang, D.,Huang, A.,Yin, Y.,Wang, D. Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion. Plos One 2013 8 0 0 4GGV 23611984 Crystal Structure of HmtT Involved in Himastatin Biosynthesis 2012-08-07 2013-07-17 Zhang, H.,Chen, J.,Wang, H.,Xie, Y.,Ju, J.,Yan, Y.,Zhang, H. Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis Febs Lett. 2013 587 1675 1680 4I6P 23643951 Crystal structure of Par3-NTD domain 2012-11-29 2013-07-17 Zhang, Y.,Wang, W.,Chen, J.,Zhang, K.,Gao, F.,Gao, B.,Zhang, S.,Dong, M.,Besenbacher, F.,Gong, W.,Zhang, M.,Sun, F.,Feng, W. Structural insights into the intrinsic self-assembly of par-3 N-terminal domain. Structure 2013 21 997 1006 4LH9 Crystal structure of the refolded hood domain (Asp256-Gly295) of HetR 2013-07-01 2013-07-17 Hu, H.X.,Jiang, Y.L.,Zhao, M.X.,Zhu, P.,Yang, X.,Ren, Y.M.,Wen, B.,Zhang, Z.,Wu, Q.,Chen, Y.,Zhang, C.C.,Zhou, C.Z. Structural and biochemical analyses of Anabaena HetR reveal insights into the cyanobacterial heterocyst development and pattern formation To be Published 0 0 0 0 4FQ5 23347155 Crystal structure of the maleate isomerase Iso(C200A) from Pseudomonas putida S16 with maleate 2012-06-25 2013-07-24 Chen, D.,Tang, H.,Lu, Y.,Zhang, Z.,Shen, K.,Lin, K.,Zhao, Y.L.,Wu, G.,Xu, P. Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside. Mol.Microbiol. 2013 87 1237 1244 4FQ7 23347155 Crystal structure of the maleate isomerase Iso from Pseudomonas putida S16 2012-06-25 2013-07-24 Chen, D.,Tang, H.,Lu, Y.,Zhang, Z.,Shen, K.,Lin, K.,Zhao, Y.L.,Wu, G.,Xu, P. Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside. Mol.Microbiol. 2013 87 1237 1244 4J0M 23709366 Crystal structure of BRL1 (LRR) in complex with brassinolide 2013-01-31 2013-07-24 She, J.,Han, Z.,Zhou, B.,Chai, J. Structural basis for differential recognition of brassinolide by its receptors Protein Cell 2013 4 475 482 4J7B 23893132 Crystal structure of polo-like kinase 1 2013-02-13 2013-07-24 Xu, J.,Shen, C.,Wang, T.,Quan, J. Structural basis for the inhibition of Polo-like kinase 1 Nat.Struct.Mol.Biol. 2013 20 1047 1053 4JDA 23844015 Complex structure of abscisic acid receptor PYL3 with (-)-ABA 2013-02-24 2013-07-24 Zhang, X.,Jiang, L.,Wang, G.,Yu, L.,Zhang, Q.,Xin, Q.,Wu, W.,Gong, Z.,Chen, Z. Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR Plos One 2013 8 0 0 4KDM 23794001 Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus 2013-04-25 2013-07-24 Lu, X.,Shi, Y.,Zhang, W.,Zhang, Y.,Qi, J.,Gao, G.F. Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell 2013 4 502 511 4KDN 23794001 Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus in complex with avian receptor analog LSTa 2013-04-25 2013-07-24 Lu, X.,Shi, Y.,Zhang, W.,Zhang, Y.,Qi, J.,Gao, G.F. Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell 2013 4 502 511 4KDO 23794001 Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus in complex with human receptor analog LSTc 2013-04-25 2013-07-24 Lu, X.,Shi, Y.,Zhang, W.,Zhang, Y.,Qi, J.,Gao, G.F. Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell 2013 4 502 511 4KDQ 23794001 Crystal structure of the hemagglutinin of A/Xinjiang/1/2006 virus 2013-04-25 2013-07-24 Lu, X.,Shi, Y.,Zhang, W.,Zhang, Y.,Qi, J.,Gao, G.F. Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell 2013 4 502 511 4L3J 23731517 Crystal structures of human p70S6K1 kinase domain 2013-06-06 2013-07-24 Wang, J.,Zhong, C.,Wang, F.,Qu, F.,Ding, J. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J. 2013 454 39 47 4L3L 23731517 Crystal structures of human p70S6K1 kinase domain (Zinc anomalous) 2013-06-06 2013-07-24 Wang, J.,Zhong, C.,Wang, F.,Qu, F.,Ding, J. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J. 2013 454 39 47 4L42 23731517 Crystal structures of human p70S6K1-PIF 2013-06-07 2013-07-24 Wang, J.,Zhong, C.,Wang, F.,Qu, F.,Ding, J. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J. 2013 454 39 47 4L43 23731517 Crystal structures of human p70S6K1-T389A (form I) 2013-06-07 2013-07-24 Wang, J.,Zhong, C.,Wang, F.,Qu, F.,Ding, J. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J. 2013 454 39 47 4L44 23731517 Crystal structures of human p70S6K1-T389A (form II) 2013-06-07 2013-07-24 Wang, J.,Zhong, C.,Wang, F.,Qu, F.,Ding, J. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J. 2013 454 39 47 4L45 23731517 Crystal structures of human p70S6K1-T389E 2013-06-07 2013-07-24 Wang, J.,Zhong, C.,Wang, F.,Qu, F.,Ding, J. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J. 2013 454 39 47 4L46 23731517 Crystal structures of human p70S6K1-WT 2013-06-07 2013-07-24 Wang, J.,Zhong, C.,Wang, F.,Qu, F.,Ding, J. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J. 2013 454 39 47 4H5U 23897470 Structural insights into yeast Nit2: wild-type yeast Nit2 2012-09-18 2013-07-31 Liu, H.,Gao, Y.,Zhang, M.,Qiu, X.,Cooper, A.J.L.,Niu, L.,Teng, M. Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2 Acta Crystallogr.,Sect.D 2013 69 1470 1481 4HG3 23897470 Structural insights into yeast Nit2: wild-type yeast Nit2 in complex with alpha-ketoglutarate 2012-10-06 2013-07-31 Liu, H.,Gao, Y.,Zhang, M.,Qiu, X.,Cooper, A.J.L.,Niu, L.,Teng, M. Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2 Acta Crystallogr.,Sect.D 2013 69 1470 1481 4HG5 23897470 Structural insights into yeast Nit2: wild-type yeast Nit2 in complex with oxaloacetate 2012-10-07 2013-07-31 Liu, H.,Gao, Y.,Zhang, M.,Qiu, X.,Cooper, A.J.L.,Niu, L.,Teng, M. Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2 Acta Crystallogr.,Sect.D 2013 69 1470 1481 4HGD 23897470 Structural insights into yeast Nit2: C169S mutant of yeast Nit2 in complex with an endogenous peptide-like ligand 2012-10-08 2013-07-31 Liu, H.,Gao, Y.,Zhang, M.,Qiu, X.,Cooper, A.J.L.,Niu, L.,Teng, M. Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2 Acta Crystallogr.,Sect.D 2013 69 1470 1481 4IC4 23791945 Crystal structure of Osh3 ORD from Saccharomyces cerevisiae 2012-12-09 2013-07-31 Tong, J.,Yang, H.,Yang, H.,Eom, S.H.,Im, Y.J. Structure of osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins Structure 2013 21 1203 1213 4JAK 23804755 Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli 2013-02-18 2013-07-31 Liu, R.J.,Zhou, M.,Fang, Z.P.,Wang, M.,Zhou, X.L.,Wang, E.D. The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL Nucleic Acids Res. 2013 41 7828 7842 4JAL 23804755 Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH 2013-02-18 2013-07-31 Liu, R.J.,Zhou, M.,Fang, Z.P.,Wang, M.,Zhou, X.L.,Wang, E.D. The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL Nucleic Acids Res. 2013 41 7828 7842 4KWE 23888039 GDP-bound, double-stranded, curved FtsZ protofilament structure 2013-05-23 2013-07-31 Li, Y.,Hsin, J.,Zhao, L.,Cheng, Y.,Shang, W.,Huang, K.C.,Wang, H.W.,Ye, S. FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation Science 2013 341 392 395 3VV3 24112706 Crystal structure of deseasin MCP-01 from Pseudoalteromonas sp. SM9913 2012-07-14 2013-08-07 Ran, L.Y.,Su, H.N.,Zhao, G.Y.,Gao, X.,Zhou, M.Y.,Wang, P.,Zhao, H.L.,Xie, B.B.,Zhang, X.Y.,Chen, X.L.,Zhou, B.C.,Zhang, Y.Z. Structural and mechanistic insights into collagen degradation by a bacterial collagenolytic serine protease in the subtilisin family. Mol. Microbiol. 2013 90 997 1010 3WDO 23950222 Structure of E. coli YajR transporter 2013-06-19 2013-08-07 Jiang, D.,Zhao, Y.,Wang, X.,Fan, J.,Heng, J.,Liu, X.,Feng, W.,Kang, X.,Huang, B.,Liu, J.,Zhang, X.C. Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A Proc.Natl.Acad.Sci.USA 2013 110 14664 14669 4FDA Crystal structure of Saccharomyces cerevisiae 3-oxoacyl-[acyl-carrier-protein] reductase complexed with NADP 2012-05-27 2013-08-07 Yujie, Z.,Yongxiang, G. Crystal structure of Saccharomyces cerevisiae 3-oxoacyl-[acyl-carrier-protein] reductase complexed with NADPH To be Published 0 0 0 0 4GFU PTPN18 in complex with HER2-pY1248 phosphor-peptides 2012-08-04 2013-08-07 Wang, H.M.,Yang, F.,Du, Y.J.,Yang, D.X.,Zhang, Y.,Yu, X.,Sun, J.P. PTPN18-HER2 peptides To be Published 0 0 0 0 4KUD 23934152 Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast nucleosome core particle 2013-05-22 2013-08-07 Yang, D.,Fang, Q.,Wang, M.,Ren, R.,Wang, H.,He, M.,Sun, Y.,Yang, N.,Xu, R.M. N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol. 2013 20 1116 1118 4KUI 23934152 Crystal structure of N-terminal acetylated yeast Sir3 BAH domain 2013-05-22 2013-08-07 Yang, D.,Fang, Q.,Wang, M.,Ren, R.,Wang, H.,He, M.,Sun, Y.,Yang, N.,Xu, R.M. N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol. 2013 20 1116 1118 4KUL 23934152 Crystal structure of N-terminal acetylated yeast Sir3 BAH domain V83P mutant 2013-05-22 2013-08-07 Yang, D.,Fang, Q.,Wang, M.,Ren, R.,Wang, H.,He, M.,Sun, Y.,Yang, N.,Xu, R.M. N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol. 2013 20 1116 1118 4GAZ Crystal Structure of a Jumonji Domain-containing Protein JMJD5 2012-07-26 2013-08-14 Wang, H.,Zhou, X.,Zhang, X.,Tao, Y.,Chen, N.,Zang, J. Crystal Structure of a Jumonji Domain-containing Protein JMJD5 To be Published 0 0 0 0 4KFP 23899614 Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 2013-04-27 2013-08-14 Dragovich, P.S.,Bair, K.W.,Baumeister, T.,Ho, Y.C.,Liederer, B.M.,Liu, X.,Liu, Y.,O'Brien, T.,Oeh, J.,Sampath, D.,Skelton, N.,Wang, L.,Wang, W.,Wu, H.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhang, L.,Zheng, X. Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett. 2013 23 4875 4885 4LG5 23835477 ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1 2013-06-27 2013-08-14 Cao, M.,Liu, X.,Zhang, Y.,Xue, X.,Zhou, X.E.,Melcher, K.,Gao, P.,Wang, F.,Zeng, L.,Zhao, Y.,Zhao, Y.,Deng, P.,Zhong, D.,Zhu, J.K.,Xu, H.E.,Xu, Y. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res. 2013 23 1043 1054 4LGA 23835477 ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1 2013-06-27 2013-08-14 Cao, M.,Liu, X.,Zhang, Y.,Xue, X.,Zhou, X.E.,Melcher, K.,Gao, P.,Wang, F.,Zeng, L.,Zhao, Y.,Zhao, Y.,Deng, P.,Zhong, D.,Zhu, J.K.,Xu, H.E.,Xu, Y. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res. 2013 23 1043 1054 4LGB 23835477 ABA-mimicking ligand N-(1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-(4-METHYLPHENYL)METHANESULFONAMIDE in complex with ABA receptor PYL2 and PP2C HAB1 2013-06-27 2013-08-14 Cao, M.,Liu, X.,Zhang, Y.,Xue, X.,Zhou, X.E.,Melcher, K.,Gao, P.,Wang, F.,Zeng, L.,Zhao, Y.,Zhao, Y.,Deng, P.,Zhong, D.,Zhu, J.K.,Xu, H.E.,Xu, Y. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res. 2013 23 1043 1054 4FQ3 Crystal structure of transportin/FUS-NLS 2012-06-25 2013-08-21 Gong, W.,Niu, C.,Jia, M.,Gao, F. Crystal structure of transportin/FUS-NLS To be Published 0 0 0 0 4L72 23835475 Crystal structure of MERS-CoV complexed with human DPP4 2013-06-13 2013-08-21 Wang, N.,Shi, X.,Jiang, L.,Zhang, S.,Wang, D.,Tong, P.,Guo, D.,Fu, L.,Cui, Y.,Liu, X.,Arledge, K.C.,Chen, Y.H.,Zhang, L.,Wang, X. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 Cell Res. 2013 23 986 993 4GQH The Conformations and Interactions of the Four-Layer Aggregate Revealed by X-ray Crystallography Diffraction Implied the Importance of Peptides at Opposite Ends in Their Assemblies 2012-08-23 2013-08-28 Li, X.Y.,Song, B.A.,Hu, D.Y.,Chen, X.,Wang, Z.C.,Zeng, M.J.,Yu, D.D.,Chen, Z.,Jin, L.H.,Yang, S. The Conformations and Interactions of the Four-Layer Aggregate Revealed by X-ray Crystallography Diffraction Implied the Importance of Peptides at Opposite Ends in Their Assemblies To be Published 0 0 0 0 4HTX 23899287 Crystal structure of PDE2 catalytic domain in complex with BAY60-7550 2012-11-02 2013-08-28 Zhu, J.,Yang, Q.,Dai, D.,Huang, Q. X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity. J.Am.Chem.Soc. 2013 135 11708 11711 4HTZ 23899287 Crystal structure of PDE2 catalytic domain in space group P1 2012-11-02 2013-08-28 Zhu, J.,Yang, Q.,Dai, D.,Huang, Q. X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity. J.Am.Chem.Soc. 2013 135 11708 11711 4K6M 23950717 Crystal Structure of the full-length Japanese encephalitis virus NS5 2013-04-16 2013-08-28 Lu, G.,Gong, P. Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface Plos Pathog. 2013 9 0 0 4KC3 23980170 Cytokine/receptor binary complex 2013-04-24 2013-08-28 Liu, X.,Hammel, M.,He, Y.,Tainer, J.A.,Jeng, U.S.,Zhang, L.,Wang, S.,Wang, X. Structural insights into the interaction of IL-33 with its receptors. Proc.Natl.Acad.Sci.USA 2013 110 14918 14923 4LRV 22525332 Crystal structure of DndE from Escherichia coli B7A involved in DNA phosphorothioation modification 2013-07-21 2013-08-28 Hu, W.,Wang, C.K.,Liang, J.D.,Zhang, T.L.,Hu, Z.P.,Wang, Z.J.,Lan, W.X.,Li, F.,Wu, H.M.,Ding, J.P.,Wu, G.,Deng, Z.X.,Cao, C. Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification Cell Res. 2012 22 1203 1206 3W3C 23985969 Crystal structure of VirB core domain complexed with the cis-acting site upstream icsb promoter 2012-12-19 2013-09-04 Gao, X.P.,Zou, T.T.,Mu, Z.X.,Qin, B.,Yang, J.,Waltersperger, S.,Wang, M.T.,Cui, S.,Jin, Q. Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes Nucleic Acids Res. 2013 41 10529 10541 4GO4 Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide 2012-08-18 2013-09-04 Su, J.,Zhang, C.,Liu, S.,Zhu, D.,Gu, L. Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide To be Published 0 0 0 0 4HA7 23620735 Structural insights into the reduction mechanism of Saccharomyces cerevisia Riboflavin Biosynthesis Reductase Rib7 2012-09-25 2013-09-04 Lv, Z.,Sun, J.,Liu, Y. Structural and functional insights into Saccharomyces cerevisiae riboflavin biosynthesis reductase RIB7. Plos One 2013 8 0 0 4HKD Crystal structure of human MST2 SARAH domain 2012-10-15 2013-09-04 Liu, G.G.,Shi, Z.B.,Zhou, Z.C. Crystal structure of human MST2 SARAH domain To be Published 0 0 0 0 4HMO 23951167 Crystal structure of streptococcus pneumoniae TIGR4 PiaA in complex with Bis-tris propane 2012-10-18 2013-09-04 Cheng, W.,Li, Q.,Jiang, Y.-L.,Zhou, C.-Z.,Chen, Y. Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters Plos One 2013 8 0 0 4HMP 23951167 Crystal structure of iron uptake ABC transporter substrate-binding protein PiaA from Streptococcus pneumoniae TIGR4 2012-10-18 2013-09-04 Cheng, W.,Li, Q.,Jiang, Y.-L.,Zhou, C.-Z.,Chen, Y. Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters Plos One 2013 8 0 0 4HMQ 23951167 Crystal structure of streptococcus pneumoniae TIGR4 PiaA in complex with ferrichrome 2012-10-18 2013-09-04 Cheng, W.,Li, Q.,Jiang, Y.-L.,Zhou, C.-Z.,Chen, Y. Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters Plos One 2013 8 0 0 4K47 23959225 Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct 2013-04-12 2013-09-04 Hu, Q.H.,Liu, R.J.,Fang, Z.P.,Zhang, J.,Ding, Y.Y.,Tan, M.,Wang, M.,Pan, W.,Zhou, H.C.,Wang, E.D. Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase Sci Rep 2013 3 2475 2475 4K48 23959225 Structure of the Streptococcus pneumoniae leucyl-tRNA synthetase editing domain 2013-04-12 2013-09-04 Hu, Q.H.,Liu, R.J.,Fang, Z.P.,Zhang, J.,Ding, Y.Y.,Tan, M.,Wang, M.,Pan, W.,Zhou, H.C.,Wang, E.D. Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase Sci Rep 2013 3 2475 2475 4L16 23979136 Crystal structure of FIGL-1 AAA domain in complex with ADP 2013-06-02 2013-09-04 Peng, W.,Lin, Z.,Li, W.,Lu, J.,Shen, Y.,Wang, C. Structural insights into the unusually strong ATPase activity of the AAA domain of the Caenorhabditis elegans fidgetin-like 1 (FIGL-1) protein. J.Biol.Chem. 2013 288 29305 29312 4HJW 23917530 Crystal structure of Metarhizium anisopliae IDCase in apo form 2012-10-14 2013-09-11 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4HK5 23917530 Crystal structure of Cordyceps militaris IDCase in apo form 2012-10-15 2013-09-11 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4HK6 23917530 Crystal structure of Cordyceps militaris IDCase in complex with 5-nitro-uracil 2012-10-15 2013-09-11 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4HK7 23917530 Crystal structure of Cordyceps militaris IDCase in complex with uracil 2012-10-15 2013-09-11 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4IXP 23922895 Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) 2013-01-27 2013-09-11 Cao, L.S.,Wang, J.,Chen, Y.,Deng, H.,Wang, Z.X.,Wu, J.W. Structural basis for the regulation of maternal embryonic leucine zipper kinase. Plos One 2013 8 0 0 4LL9 23955630 Crystal structure of D3D4 domain of the LILRB1 molecule 2013-07-09 2013-09-11 Nam, G.,Shi, Y.,Ryu, M.,Wang, Q.,Song, H.,Liu, J.,Yan, J.,Qi, J.,Gao, G.F. Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding Protein Cell 2013 4 761 770 4LLA 23955630 Crystal structure of D3D4 domain of the LILRB2 molecule 2013-07-09 2013-09-11 Nam, G.,Shi, Y.,Ryu, M.,Wang, Q.,Song, H.,Liu, J.,Yan, J.,Qi, J.,Gao, G.F. Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding Protein Cell 2013 4 761 770 4M4E 23982741 TRAF domain of human TRAF4 2013-08-07 2013-09-11 Niu, F.,Ru, H.,Ding, W.,Ouyang, S.,Liu, Z.J. Structural biology study of human TNF receptor associated factor 4 TRAF domain Protein Cell 2013 4 687 694 4H47 1.9 angstrom CyPet structure at pH5.2 2012-09-17 2013-09-18 Liu, R.,Zhou, Y.-B.,Ding, Y.,Hu, X.-J. Structural insights of the fluorescent states of CyPet To be Published 0 0 0 0 4H48 1.45 angstrom CyPet Structure at pH7.0 2012-09-17 2013-09-18 Liu, R.,Zhou, Y.-B.,Ding, Y.,Hu, X.-J. Structure insight of the fluorescent state of CyPet To be Published 0 0 0 0 4JEK 23722833 Structure of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis 2013-02-27 2013-09-18 Duan, X.,Zhang, L.,Zhou, D.,Ji, K.,Ma, T.,Shui, W.,Li, G.,Li, X. Crystallization and preliminary structural analysis of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis Acta Crystallogr.,Sect.F 2013 69 597 601 4LUQ 24025333 Crystal structure of virulence effector Tse3 in complex with neutralizer Tsi3 2013-07-25 2013-09-18 Li, L.,Zhang, W.,Liu, Q.,Gao, Y.,Gao, Y.,Wang, Y.,Wang, D.Z.,Li, Z.,Wang, T. Structural Insights on the Bacteriolytic and Self-protection Mechanism of Muramidase Effector Tse3 in Pseudomonas aeruginosa J.Biol.Chem. 2013 288 30607 30613 4H5Y 24293259 High-resolution crystal structure of Legionella pneumophila LidA (60-594) 2012-09-19 2013-09-25 Meng, G.,An, X.,Ye, S.,Liu, Y.,Zhu, W.,Zhang, R.,Zheng, X. The crystal structure of LidA, a translocated substrate of the Legionella pneumophila type IV secretion system. Protein Cell 2013 4 897 900 4LV9 24021463 Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 2013-07-26 2013-09-25 Zheng, X.,Bair, K.W.,Bauer, P.,Baumeister, T.,Bowman, K.K.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Feng, Y.,Han, B.,Ho, Y.C.,Kley, N.,Li, H.,Liang, X.,Liederer, B.M.,Lin, J.,Ly, J.,O'Brien, T.,Oeh, J.,Oh, A.,Reynolds, D.J.,Sampath, D.,Sharma, G.,Skelton, N.,Smith, C.C.,Tremayne, J.,Wang, L.,Wang, W.,Wang, Z.,Wu, H.,Wu, J.,Xiao, Y.,Yang, G.,Yuen, P.W.,Zak, M.,Dragovich, P.S. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett. 2013 23 5488 5497 4LVD 24021463 Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 2013-07-26 2013-09-25 Zheng, X.,Bair, K.W.,Bauer, P.,Baumeister, T.,Bowman, K.K.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Feng, Y.,Han, B.,Ho, Y.C.,Kley, N.,Li, H.,Liang, X.,Liederer, B.M.,Lin, J.,Ly, J.,O'Brien, T.,Oeh, J.,Oh, A.,Reynolds, D.J.,Sampath, D.,Sharma, G.,Skelton, N.,Smith, C.C.,Tremayne, J.,Wang, L.,Wang, W.,Wang, Z.,Wu, H.,Wu, J.,Xiao, Y.,Yang, G.,Yuen, P.W.,Zak, M.,Dragovich, P.S. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett. 2013 23 5488 5497 4LVF 24021463 Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 2013-07-26 2013-09-25 Zheng, X.,Bair, K.W.,Bauer, P.,Baumeister, T.,Bowman, K.K.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Feng, Y.,Han, B.,Ho, Y.C.,Kley, N.,Li, H.,Liang, X.,Liederer, B.M.,Lin, J.,Ly, J.,O'Brien, T.,Oeh, J.,Oh, A.,Reynolds, D.J.,Sampath, D.,Sharma, G.,Skelton, N.,Smith, C.C.,Tremayne, J.,Wang, L.,Wang, W.,Wang, Z.,Wu, H.,Wu, J.,Xiao, Y.,Yang, G.,Yuen, P.W.,Zak, M.,Dragovich, P.S. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett. 2013 23 5488 5497 4LVG 24021463 Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 2013-07-26 2013-09-25 Zheng, X.,Bair, K.W.,Bauer, P.,Baumeister, T.,Bowman, K.K.,Buckmelter, A.J.,Caligiuri, M.,Clodfelter, K.H.,Feng, Y.,Han, B.,Ho, Y.C.,Kley, N.,Li, H.,Liang, X.,Liederer, B.M.,Lin, J.,Ly, J.,O'Brien, T.,Oeh, J.,Oh, A.,Reynolds, D.J.,Sampath, D.,Sharma, G.,Skelton, N.,Smith, C.C.,Tremayne, J.,Wang, L.,Wang, W.,Wang, Z.,Wu, H.,Wu, J.,Xiao, Y.,Yang, G.,Yuen, P.W.,Zak, M.,Dragovich, P.S. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett. 2013 23 5488 5497 4HX1 23566939 Structure of HLA-A68 complexed with a tumor antigen derived peptide 2012-11-09 2013-10-02 Niu, L.,Cheng, H.,Zhang, S.,Tan, S.,Zhang, Y.,Qi, J.,Liu, J.,Gao, G.F. Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol. 2013 55 381 392 4I48 23566939 Structure of HLA-A68 complexed with an HIV Env derived peptide 2012-11-27 2013-10-02 Niu, L.,Cheng, H.,Zhang, S.,Tan, S.,Zhang, Y.,Qi, J.,Liu, J.,Gao, G.F. Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol. 2013 55 381 392 4IX3 23794031 Crystal structure of a Stt7 homolog from Micromonas algae 2013-01-24 2013-10-02 Guo, J.,Wei, X.,Li, M.,Pan, X.,Chang, W.,Liu, Z. Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae Protein Cell 2013 4 607 619 4IX4 23794031 Crystal structure of a Stt7 homolog from Micromonas algae in complex with ADP 2013-01-24 2013-10-02 Guo, J.,Wei, X.,Li, M.,Pan, X.,Chang, W.,Liu, Z. Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae Protein Cell 2013 4 607 619 4IX5 23794031 Crystal structure of a Stt7 homolog from Micromonas algae in complex with AMP-PNP 2013-01-24 2013-10-02 Guo, J.,Wei, X.,Li, M.,Pan, X.,Chang, W.,Liu, Z. Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae Protein Cell 2013 4 607 619 4IX6 23794031 Crystal structure of a Stt7 homolog from Micromonas algae soaked with ATP 2013-01-24 2013-10-02 Guo, J.,Wei, X.,Li, M.,Pan, X.,Chang, W.,Liu, Z. Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae Protein Cell 2013 4 607 619 4K35 18802694 The structure of a glycoside hydrolase family 81 endo-[beta]-1,3-glucanase 2013-04-10 2013-10-02 Zhou, P.,Chen, Z.Z.,Yan, Q.J.,Yang, S.Q.,Hilgenfeld, R.,Jiang, Z.Q. The structure of a glycoside hydrolase family 81 endo-[beta]-1,3-glucanase Acta Crystallogr.,Sect.D 2013 69 2027 2038 4LAK 23917530 Crystal structure of Cordyceps militaris IDCase D323N mutant in apo form 2013-06-20 2013-10-02 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4LAL 23917530 Crystal structure of Cordyceps militaris IDCase D323A mutant in complex with 5-carboxyl-uracil 2013-06-20 2013-10-02 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4LAM 23917530 Crystal structure of Cordyceps militaris IDCase D323N mutant in complex with 5-carboxyl-uracil 2013-06-20 2013-10-02 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4LAN 23917530 Crystal structure of Cordyceps militaris IDCase H195A mutant 2013-06-20 2013-10-02 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4LAO 23917530 Crystal structure of Cordyceps militaris IDCase H195A mutant (Zn) 2013-06-20 2013-10-02 Xu, S.,Li, W.,Zhu, J.,Wang, R.,Li, Z.,Xu, G.L.,Ding, J. Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res. 2013 23 1296 1309 4M6T 24038468 Structure of human Paf1 and Leo1 complex 2013-08-11 2013-10-02 Chu, X.,Qin, X.,Xu, H.,Li, L.,Wang, Z.,Li, F.,Xie, X.,Zhou, H.,Shen, Y.,Long, J. Structural insights into Paf1 complex assembly and histone binding Nucleic Acids Res. 2013 41 10619 10629 4M6W 24003026 Crystal structure of the C-terminal segment of FANCM in complex with FAAP24 2013-08-11 2013-10-02 Yang, H.,Zhang, T.,Tao, Y.,Wang, F.,Tong, L.,Ding, J. Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucleic Acids Res. 2013 41 10573 10583 4HCB The metal-free form of crystal structure of E.coli ExoI-ssDNA complex 2012-09-29 2013-10-09 Qiu, R.,Lou, T.,Wei, J.,Liu, M.,Gu, S.,Tang, R.,Ji, C.,Gong, W. The structures of Escherichia coli exonuclease I in complex with the single strand DNA To be published 0 0 0 0 4HCC The zinc ion bound form of crystal structure of E.coli ExoI-ssDNA complex 2012-09-29 2013-10-09 Qiu, R.,Lou, T.,Wei, J.,Liu, M.,Gu, S.,Tang, R.,Ji, C.,Gong, W. The structures of Escherichia coli exonuclease I in complex with the single strand DNA To be published 0 0 0 0 4MOD 24067982 Structure of the MERS-CoV fusion core 2013-09-12 2013-10-09 Gao, J.,Lu, G.,Qi, J.,Li, Y.,Wu, Y.,Deng, Y.,Geng, H.,Li, H.,Wang, Q.,Xiao, H.,Tan, W.,Yan, J.,Gao, G.F. Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus. J.Virol. 2013 87 13134 13140 3WFV 24074570 HIV-1 CRF07 gp41 2013-07-24 2013-10-16 Du, J.,Xue, H.,Ma, J.,Liu, F.,Zhou, J.,Shao, Y.,Qiao, W.,Liu, X. The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat Virology 2013 446 86 94 4HOW 24069347 The crystal structure of isomaltulose synthase from Erwinia rhapontici NX5 2012-10-22 2013-10-16 Xu, Z.,Li, S.,Li, J.,Li, Y.,Feng, X.,Wang, R.,Xu, H.,Zhou, J. The Structural Basis of Erwinia rhapontici Isomaltulose Synthase Plos One 2013 8 0 0 4HOZ 24069347 The crystal structure of isomaltulose synthase mutant D241A from Erwinia rhapontici NX5 in complex with D-glucose 2012-10-23 2013-10-16 Xu, Z.,Li, S.,Li, J.,Li, Y.,Feng, X.,Wang, R.,Xu, H.,Zhou, J. The Structural Basis of Erwinia rhapontici Isomaltulose Synthase Plos One 2013 8 0 0 4HPH 24069347 The crystal structure of isomaltulose synthase mutant E295Q from Erwinia rhapontici NX5 in complex with its natural substrate sucrose 2012-10-23 2013-10-16 Xu, Z.,Li, S.,Li, J.,Li, Y.,Feng, X.,Wang, R.,Xu, H.,Zhou, J. The Structural Basis of Erwinia rhapontici Isomaltulose Synthase Plos One 2013 8 0 0 4JBA 24185215 Crystal Structure of the Oxidized Form of MarR from E.coli 2013-02-19 2013-10-16 Hao, Z.,Lou, H.,Zhu, R.,Zhu, J.,Zhang, D.,Zhao, B.S.,Zeng, S.,Chen, X.,Chan, J.,He, C.,Chen, P.R. The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli. Nat.Chem.Biol. 2014 10 21 28 4JWF 24081582 Crystal structure of spTrm10(74)-SAH complex 2013-03-27 2013-10-16 Shao, Z.,Yan, W.,Peng, J.,Zuo, X.,Zou, Y.,Li, F.,Gong, D.,Ma, R.,Wu, J.,Shi, Y.,Zhang, Z.,Teng, M.,Li, X.,Gong, Q. Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res. 2014 42 509 525 4JWG 24081582 Crystal structure of spTrm10(74) 2013-03-27 2013-10-16 Shao, Z.,Yan, W.,Peng, J.,Zuo, X.,Zou, Y.,Li, F.,Gong, D.,Ma, R.,Wu, J.,Shi, Y.,Zhang, Z.,Teng, M.,Li, X.,Gong, Q. Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res. 2014 42 509 525 4JWH 24081582 Crystal structure of spTrm10(Full length)-SAH complex 2013-03-27 2013-10-16 Shao, Z.,Yan, W.,Peng, J.,Zuo, X.,Zou, Y.,Li, F.,Gong, D.,Ma, R.,Wu, J.,Shi, Y.,Zhang, Z.,Teng, M.,Li, X.,Gong, Q. Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res. 2014 42 509 525 4JWJ 24081582 Crystal structure of scTrm10(84)-SAH complex 2013-03-27 2013-10-16 Shao, Z.,Yan, W.,Peng, J.,Zuo, X.,Zou, Y.,Li, F.,Gong, D.,Ma, R.,Wu, J.,Shi, Y.,Zhang, Z.,Teng, M.,Li, X.,Gong, Q. Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res. 2014 42 509 525 4M66 24095729 Crystal structure of the mouse RIP3 kinase domain 2013-08-09 2013-10-16 Xie, T.,Peng, W.,Yan, C.,Wu, J.,Gong, X.,Shi, Y. Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep 2013 5 70 78 4M69 24095729 Crystal structure of the mouse RIP3-MLKL complex 2013-08-09 2013-10-16 Xie, T.,Peng, W.,Yan, C.,Wu, J.,Gong, X.,Shi, Y. Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep 2013 5 70 78 4M7E Structural insight into BL-induced activation of the BRI1-BAK1 complex 2013-08-12 2013-10-16 Sun, Y.,Han, Z.,Chai, J. Structural insight into BL-induced activation of the BRI1-BAK1 complex To be Published 0 0 0 0 4GFV PTPN18 in complex with HER2-pY1196 phosphor-peptides 2012-08-04 2013-10-23 Wang, H.M.,Yang, F.,Du, Y.J.,Yang, D.X.,Zhang, Y.,Yu, X.,Sun, J.P. PTPN18-HER2 peptides To be Published 0 0 0 0 4HWV 23568384 Structure of Pectate Lyase from Acidovorax avenae subsp citrulli 2012-11-09 2013-10-23 Tang, Q.,Liu, Y.P.,Ren, Z.G.,Yan, X.X.,Zhang, L.Q. 1.37 angstrom crystal structure of pathogenic factor pectate lyase from Acidovorax citrulli. Proteins 2013 81 1485 1490 4KGB 24100554 Structure of succinyl-CoA: 3-ketoacid CoA transferase from Drosophila melanogaster 2013-04-29 2013-10-23 Zhang, M.,Xu, H.Y.,Wang, Y.C.,Shi, Z.B.,Zhang, N.N. Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. Acta Crystallogr.,Sect.F 2013 69 1089 1093 4M75 24240276 Crystal structure of Lsm1-7 complex 2013-08-12 2013-10-23 Zhou, L.,Hang, J.,Zhou, Y.,Wan, R.,Lu, G.,Yin, P.,Yan, C.,Shi, Y. Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature 2014 506 116 120 4HBG Crystal structure of Saccharomyces cerevisiae 3 oxoacyl-[acyl carrier protein]-reductase complexed with NADPH (form2) 2012-09-27 2013-10-30 Zhang, Y.J.,Gao, Y.X.,Teng, M.K. Crystal structure of yeast mitochondria 3-Oxoacyl-ACP Reductase OAR1 To be Published 0 0 0 0 4HPW Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine 2012-10-24 2013-10-30 Yu, Y.,Zhou, Q.,Dong, J.,Li, J.,Xiaoxuan, L.,Mukherjee, A.,Ouyang, H.,Nilges, M.,Li, H.,Gao, F.,Gong, W.,Lu, Y.,Wang, J. Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine To be Published 0 0 0 0 4JLW 23989142 Crystal structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa 2013-03-13 2013-10-30 Liao, Y.P.,Chen, S.,Wang, D.L.,Zhang, W.,Wang, S.,Ding, J.F.,Wang, Y.M.,Cai, L.J.,Ran, X.Y.,Wang, X.,Zhu, H.X. Structure of formaldehyde dehydrogenase from Pseudomonas aeruginosa: the binary complex with the cofactor NAD+. Acta Crystallogr.,Sect.F 2013 69 967 972 4JZR 24055079 Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors 2013-04-03 2013-10-30 Deng, G.,Zhao, B.,Ma, Y.,Xu, Q.,Wang, H.,Yang, L.,Zhang, Q.,Guo, T.B.,Zhang, W.,Jiao, Y.,Cai, X.,Zhang, J.,Liu, H.,Guan, X.,Lu, H.,Xiang, J.,Elliott, J.D.,Lin, X.,Ren, F. Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors Bioorg.Med.Chem. 2013 21 6349 6358 4M59 24162847 Crystal structure of the pentatricopeptide repeat protein PPR10 in complex with an 18-nt psaJ RNA element 2013-08-08 2013-10-30 Yin, P.,Li, Q.,Yan, C.,Liu, Y.,Liu, J.,Yu, F.,Wang, Z.,Long, J.,He, J.,Wang, H.W.,Wang, J.,Zhu, J.K.,Shi, Y.,Yan, N. Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature 2013 504 168 171 4MKI 24104393 Cobalt transporter ATP-binding subunit 2013-09-05 2013-10-30 Chai, C.L.,Yu, Y.,Zhuo, W.,Zhao, H.,Li, X.,Wang, N.,Chai, J.,Yang, M. Structural basis for a homodimeric ATPase subunit of an ECF transporter Protein Cell 2013 4 793 801 4HZV 23824808 The crystal structure of influenza A neuraminidase N3 2012-11-15 2013-11-06 Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F. Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance. J.Virol. 2013 87 10016 10024 4HZW 23824808 Crystal structure of influenza A neuraminidase N3 complexed with laninamivir 2012-11-15 2013-11-06 Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F. Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance. J.Virol. 2013 87 10016 10024 4HZY 23824808 Crystal structure of influenza A neuraminidase N3-H274Y 2012-11-16 2013-11-06 Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F. Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance. J.Virol. 2013 87 10016 10024 4JDE 23799143 Crystal structure of PUD-1/PUD-2 heterodimer 2013-02-25 2013-11-06 Ding, Y.H.,Du, Y.G.,Luo, S.,Li, Y.X.,Li, T.M.,Yoshina, S.,Wang, X.,Klage, K.,Mitani, S.,Ye, K.,Dong, M.Q. Characterization of PUD-1 and PUD-2, two proteins up-regulated in a long-lived daf-2 mutant. Plos One 2013 8 0 0 4KOL 24009358 The structure of hemagglutinin from avian-origin H7N9 influenza virus 2013-05-12 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science 2013 342 243 247 4KOM 24009358 The structure of hemagglutinin from avian-origin H7N9 influenza virus in complex with avian receptor analog 3'SLNLN (NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc) 2013-05-12 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science 2013 342 243 247 4KON 24009358 The structure of hemagglutinin from avian-origin H7N9 influenza virus in complex with human receptor analog 6'SLNLN (NeuAcα2-6Galβ1-4GlcNAcβ1-3Galβ1-4Glc) 2013-05-12 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science 2013 342 243 247 4LCX 24009358 The structure of hemagglutinin from avian-origin H7N9 influenza virus (A/Shanghai/1/2013) 2013-06-24 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science 2013 342 243 247 4LKG 24009358 The structure of hemagglutinin from a avian-origin H7N9 influenza virus (A/Shanghai/1/2013) in complex with avian receptor analog 3'SLNLN 2013-07-07 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses Science 2013 342 243 247 4LKH 24009358 The structure of hemagglutinin from a avian-origin H7N9 influenza virus (A/Shanghai/1/2013) in complex with human receptor analog 6'SLNLN 2013-07-07 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses Science 2013 342 243 247 4LKI 24009358 The structure of hemagglutinin L226Q mutant from a avian-origin H7N9 influenza virus (A/Anhui/1/2013) 2013-07-07 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses Science 2013 342 243 247 4LKJ 24009358 The structure of hemagglutinin L226Q mutant (H3 numbering) from a avian-origin H7N9 influenza virus (A/Anhui/1/2013) in complex with avian receptor analog 3'SLNLN 2013-07-07 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses Science 2013 342 243 247 4LKK 24009358 The structure of hemagglutinin L226Q mutant (H3 numbering) from a avian-origin H7N9 influenza virus (A/Anhui/1/2013) in complex with human receptor analog 6'SLNLN 2013-07-07 2013-11-06 Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses Science 2013 342 243 247 4MJ7 24152547 Crystal structure of the PIN domain of Saccharomyces cerevisiae Utp23 2013-09-03 2013-11-06 Lu, J.,Sun, M.,Ye, K. Structural and functional analysis of Utp23, a yeast ribosome synthesis factor with degenerate PIN domain Rna 2013 19 1815 1824 4HOX The crystal structure of isomaltulose synthase from Erwinia rhapontici NX5 in complex with Tris 2012-10-23 2013-11-13 Xu, Z.,Li, S.,Xu, H.,Zhou, J. The crystal structure of isomaltulose synthase from Erwinia rhapontici NX5 in complex with Tris to be published 0 0 0 0 4HP5 The crystal structure of isomaltulose synthase mutant E295A from Erwinia rhapontici NX5 in complex with D-glucose 2012-10-23 2013-11-13 Xu, Z.,Li, S.,Xu, H.,Zhou, J. The crystal structure of isomaltulose synthase mutant E295A from Erwinia rhapontici NX5 in complex with D-glucose to be published 0 0 0 0 4IVS 23681056 Crystal structure of BACE1 with its inhibitor 2013-01-23 2013-11-13 Zou, Y.,Li, L.,Chen, W.Y.,Chen, T.T.,Ma, L.,Wang, X.,Xiong, B.,Xu, Y.C.,Shen, J. Virtual screening and structure-based discovery of indole acylguanidines as potent beta-secretase (BACE1) inhibitors Molecules 2013 18 5706 5722 4IVT 23681056 Crystal structure of BACE1 with its inhibitor 2013-01-23 2013-11-13 Zou, Y.,Li, L.,Chen, W.Y.,Chen, T.T.,Ma, L.,Wang, X.,Xiong, B.,Xu, Y.C.,Shen, J. Virtual screening and structure-based discovery of indole acylguanidines as potent beta-secretase (BACE1) inhibitors Molecules 2013 18 5706 5722 4M70 24194517 Crystal structure of potato Rx-CC domain in complex with RanGAP2-WPP domain 2013-08-12 2013-11-13 Hao, W.,Collier, S.M.,Moffett, P.,Chai, J. Structural Basis for the Interaction between the Potato Virus X Resistance Protein (Rx) and Its Cofactor Ran GTPase-activating Protein 2 (RanGAP2) J.Biol.Chem. 2013 288 35868 35876 4M77 24240276 Crystal structure of Lsm2-8 complex, space group I212121 2013-08-12 2013-11-13 Zhou, L.,Hang, J.,Zhou, Y.,Wan, R.,Lu, G.,Yin, P.,Yan, C.,Shi, Y. Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature 2014 506 116 120 4M7A 24240276 Crystal structure of Lsm2-8 complex bound to the 3' end sequence of U6 snRNA 2013-08-12 2013-11-13 Zhou, L.,Hang, J.,Zhou, Y.,Wan, R.,Lu, G.,Yin, P.,Yan, C.,Shi, Y. Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature 2014 506 116 120 4M7D 24240276 Crystal structure of Lsm2-8 complex bound to the RNA fragment CGUUU 2013-08-12 2013-11-13 Zhou, L.,Hang, J.,Zhou, Y.,Wan, R.,Lu, G.,Yin, P.,Yan, C.,Shi, Y. Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature 2014 506 116 120 4N0G 24165892 Crystal Structure of PYL13-PP2CA complex 2013-10-01 2013-11-13 Li, W.,Wang, L.,Sheng, X.,Yan, C.,Zhou, R.,Hang, J.,Yin, P.,Yan, N. Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13 Cell Res. 2013 23 1369 1379 4KM8 24217340 Crystal structure of Sufud60 2013-05-08 2013-11-20 Zhang, Y.,Fu, L.,Qi, X.,Zhang, Z.,Xia, Y.,Jia, J.,Jiang, J.,Zhao, Y.,Wu, G. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 2013 4 2608 2608 4KM9 24217340 Crystal structure of human Suppressor of Fused 2013-05-08 2013-11-20 Zhang, Y.,Fu, L.,Qi, X.,Zhang, Z.,Xia, Y.,Jia, J.,Jiang, J.,Zhao, Y.,Wu, G. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 2013 4 2608 2608 4KMA 24217340 Crystal structure of Drosophila Suppressor of Fused 2013-05-08 2013-11-20 Zhang, Y.,Fu, L.,Qi, X.,Zhang, Z.,Xia, Y.,Jia, J.,Jiang, J.,Zhao, Y.,Wu, G. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 2013 4 2608 2608 4KMD 24217340 Crystal structure of Sufud60-Gli1p 2013-05-08 2013-11-20 Zhang, Y.,Fu, L.,Qi, X.,Zhang, Z.,Xia, Y.,Jia, J.,Jiang, J.,Zhao, Y.,Wu, G. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 2013 4 2608 2608 4KMH 24217340 Crystal structure of Suppressor of Fused d20 2013-05-08 2013-11-20 Zhang, Y.,Fu, L.,Qi, X.,Zhang, Z.,Xia, Y.,Jia, J.,Jiang, J.,Zhao, Y.,Wu, G. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun 2013 4 2608 2608 4MWH 24531484 Crystal structure of scCK2 alpha in complex with ATP 2013-09-24 2013-11-20 Liu, H.,Wang, H.,Teng, M.,Li, X. The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D 2014 70 501 513 4MWJ 24165891 Anhui N9 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWL 24165891 Shanghai N9 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWQ 24165891 Anhui N9-oseltamivir carboxylate 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWR 24165891 Anhui N9-zanamivir 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWU 24165891 Anhui N9-laninamivir 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWV 24165891 Anhui N9-peramivir 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWW 24165891 Shanghai N9-oseltamivir carboxylate 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWX 24165891 Shanghai N9-zanamivir 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MWY 24165891 Shanghai N9-laninamivir 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4MX0 24165891 Shanghai N9-peramivir 2013-09-25 2013-11-20 Wu, Y.,Bi, Y.H.,Vavricka, C.J.,Sun, X.M.,Zhang, Y.F.,Gao, F.,Zhao, M.,Xiao, H.X.,Qin, C.F.,He, J.H.,Liu, W.J.,Yan, J.H.,Qi, J.X.,Gao, G.F. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res. 2013 23 1347 1355 4I35 The crystal structure of serralysin 2012-11-24 2013-11-27 Wang, W.,Xu, D.,Zou, M.,Ran, T. The crystal structure of serralysin To be Published 0 0 0 0 4IJC 24192347 Crystal structure of arabinose dehydrogenase Ara1 from Saccharomyces cerevisiae 2012-12-21 2013-11-27 Hu, X.Q.,Guo, P.C.,Ma, J.D.,Li, W.F. Structures of Saccharomyces cerevisiaeD-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition Acta Crystallogr.,Sect.F 2013 69 1190 1195 4IJR 24192347 Crystal structure of Saccharomyces cerevisiae arabinose dehydrogenase Ara1 complexed with NADPH 2012-12-23 2013-11-27 Hu, X.Q.,Guo, P.C.,Ma, J.D.,Li, W.F. Structures of Saccharomyces cerevisiaeD-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition Acta Crystallogr.,Sect.F 2013 69 1190 1195 4I8B 25810021 Crystal Structure of Thioredoxin from Schistosoma Japonicum 2012-12-03 2013-12-04 Li, Y.,Li, P.,Peng, Y.,Wu, Q.,Huang, F.,Liu, X.,Li, X.,Zhou, H.,Guo, D.,Shi, D.,Zhou, X.N.,Fan, X. Expression, characterization and crystal structure of thioredoxin from Schistosoma japonicum. Parasitology 2015 142 1044 1052 4MN8 24114786 Crystal structure of flg22 in complex with the FLS2 and BAK1 ectodomains 2013-09-10 2013-12-04 Sun, Y.,Li, L.,Macho, A.P.,Han, Z.,Hu, Z.,Zipfel, C.,Zhou, J.M.,Chai, J. Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science 2013 342 624 628 4MNA 24114786 Crystal structure of the free FLS2 ectodomains 2013-09-10 2013-12-04 Sun, Y.,Li, L.,Macho, A.P.,Han, Z.,Hu, Z.,Zipfel, C.,Zhou, J.M.,Chai, J. Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science 2013 342 624 628 4IC0 Crystal Structure of PAI-1 in Complex with Gallate 2012-12-09 2013-12-11 Hong, Z.B.,Lin, Z.H.,Gong, L.H.,Huang, M.D. Crystal Structure of PAI-1 in Complex with Gallate To be Published 0 0 0 0 4ICK 23384440 Crystal structure of human AP4A hydrolase E58A mutant 2012-12-10 2013-12-11 Ge, H.,Chen, X.,Yang, W.,Niu, L.,Teng, M. Crystal structure of wild-type and mutant human Ap4A hydrolase. Biochem.Biophys.Res.Commun. 2013 432 16 21 4ICZ HER2 1221/1222 phosphorylation regulated by PTPN9 2012-12-11 2013-12-11 Xu, Y.F.,Wang, H.M.,Liu, C.H.,Yu, X.,Sun, J.P. HER2 1221/1222 phosphorylation regulated by PTPN9 To be Published 0 0 0 0 4L36 24282603 Crystal structure of the cytochrome P450 enzyme TxtE 2013-06-05 2013-12-11 Yu, F.,Li, M.J.,Xu, C.Y.,Wang, Z.J.,Zhou, H.,Yang, M.,Chen, Y.X.,Tang, L.,He, J.H. Structural Insights into the Mechanism for Recognizing Substrate of the Cytochrome P450 Enzyme TxtE. Plos One 2013 8 0 0 4LJY 24290758 Crystal structure of RNA splicing effector Prp5 in complex with ADP 2013-07-05 2013-12-11 Zhang, Z.M.,Yang, F.,Zhang, J.,Tang, Q.,Li, J.,Gu, J.,Zhou, J.,Xu, Y.Z. Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep 2013 5 1269 1278 4LK2 24290758 Crystal structure of RNA splicing effector Prp5 2013-07-05 2013-12-11 Zhang, Z.M.,Yang, F.,Zhang, J.,Tang, Q.,Li, J.,Gu, J.,Zhou, J.,Xu, Y.Z. Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep 2013 5 1269 1278 4NAC Crystal Structure of the N-terminal Domain of p15RS 2013-10-22 2013-12-11 Mei, K.,Jin, Z.,Ren, F.,Wang, Y.,Chang, Z.,Wang, X. Crystal Structure of the N-terminal Domain of p15RS To be Published 0 0 0 0 4NAD Crystal Structure of the C-terminal Domain of CREPT 2013-10-22 2013-12-11 Mei, K.,Jin, Z.,Ren, F.,Wang, Y.,Chang, Z.,Wang, X. Crystal Structure of the C-terminal Domain of CREPT To be Published 0 0 0 0 4IF2 30704759 Structure of the phosphotriesterase from Mycobacterium tuberculosis 2012-12-13 2013-12-18 Zhang, L.,Wang, H.,Liu, X.,Zhou, W.,Rao, Z. The crystal structure of the phosphotriesterase from M. tuberculosis, another member of phosphotriesterase-like lactonase family. Biochem.Biophys.Res.Commun. 2019 510 224 229 4IFT Crystal structure of double mutant thermostable NPPase from Geobacillus stearothermophilus 2012-12-15 2013-12-18 Guo, Z.,Huang, J.,Wang, F.,Qiu, R.,Wang, Y.,Ji, C. Crystal structure of thermostable NPPase from Geobacillus stearothermophilus To be Published 0 0 0 0 4IG4 Crystal structure of single mutant thermostable NPPase (N86S) from Geobacillus stearothermophilus 2012-12-16 2013-12-18 Guo, Z.,Wang, F.,Huang, J.,Qiu, R.,Yang, Z.,Wang, Y.,Ji, C. Crystal structure of thermostable NPPase from Geobacillus stearothermophilus To be Published 0 0 0 0 4JGV 24316735 Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN 2013-03-04 2013-12-18 Wang, W.,Wang, Y.,Chen, H.,Xing, Y.,Li, F.,Zhang, Q.,Zhou, B.,Zhang, H.,Zhang, J.,Bian, X.,Li, L.,Liu, Y.,Zhao, B.,Chen, Y.,Wu, R.,Li, A.,Yao, L.,Chen, P.,Zhang, Y.,Tian, X.,Beermann, F.,Wu, M.,Han, J.,Huang, P.,Lin, T.,Wu, Q. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 2014 10 133 140 4KR1 24311582 Crystal structure of the kinetechore protein Iml3 from budding yeast 2013-05-16 2013-12-18 Guo, Q.,Tao, Y.,Liu, H.,Teng, M.,Li, X. Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly Acta Crystallogr.,Sect.D 2013 69 2412 2419 4KZI 24316735 Crystal Structure of TR3 LBD in complex with DPDO 2013-05-30 2013-12-18 Wang, W.J.,Wang, Y.,Chen, H.Z.,Xing, Y.Z.,Li, F.W.,Zhang, Q.,Zhou, B.,Zhang, H.K.,Zhang, J.,Bian, X.L.,Li, L.,Liu, Y.,Zhao, B.X.,Chen, Y.,Wu, R.,Li, A.Z.,Yao, L.M.,Chen, P.,Zhang, Y.,Tian, X.Y.,Beermann, F.,Wu, M.,Han, J.,Huang, P.Q.,Lin, T.,Wu, Q. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 2014 10 133 140 4KZJ 24316735 Crystal Structure of TR3 LBD L449W Mutant 2013-05-30 2013-12-18 Wang, W.J.,Wang, Y.,Chen, H.Z.,Xing, Y.Z.,Li, F.W.,Zhang, Q.,Zhou, B.,Zhang, H.K.,Zhang, J.,Bian, X.L.,Li, L.,Liu, Y.,Zhao, B.X.,Chen, Y.,Wu, R.,Li, A.Z.,Yao, L.M.,Chen, P.,Zhang, Y.,Tian, X.Y.,Beermann, F.,Wu, M.,Han, J.,Huang, P.Q.,Lin, T.,Wu, Q. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 2014 10 133 140 4KZM 24316735 Crystal Structure of TR3 LBD S553A Mutant 2013-05-30 2013-12-18 Wang, W.J.,Wang, Y.,Chen, H.Z.,Xing, Y.Z.,Li, F.W.,Zhang, Q.,Zhou, B.,Zhang, H.K.,Zhang, J.,Bian, X.L.,Li, L.,Liu, Y.,Zhao, B.X.,Chen, Y.,Wu, R.,Li, A.Z.,Yao, L.M.,Chen, P.,Zhang, Y.,Tian, X.Y.,Beermann, F.,Wu, M.,Han, J.,Huang, P.Q.,Lin, T.,Wu, Q. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 2014 10 133 140 4NFZ 24284327 Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10 2013-11-01 2013-12-18 Tefsen, B.,Lu, G.,Zhu, Y.,Haywood, J.,Zhao, L.,Deng, T.,Qi, J.,Gao, G.F. The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity J.Virol. 2014 88 1935 1941 4NM6 24315485 Crystal structure of TET2-DNA complex 2013-11-14 2013-12-18 Hu, L.,Li, Z.,Cheng, J.,Rao, Q.,Gong, W.,Liu, M.,Shi, Y.G.,Zhu, J.,Wang, P.,Xu, Y. Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation. Cell(Cambridge,Mass.) 2013 155 1545 1555 4I9Z 23867165 Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 2012-12-05 2014-01-01 Gong, X.,Wang, G.,Ren, J.,Liu, Z.,Wang, Z.,Chen, T.,Yang, X.,Jiang, X.,Shen, J.,Jiang, H.,Aisa, H.A.,Xu, Y.,Li, J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett. 2013 23 4944 4947 4IA0 23867165 Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 2012-12-05 2014-01-01 Gong, X.,Wang, G.,Ren, J.,Liu, Z.,Wang, Z.,Chen, T.,Yang, X.,Jiang, X.,Shen, J.,Jiang, H.,Aisa, H.A.,Xu, Y.,Li, J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett. 2013 23 4944 4947 4ILE Structure of human ADP-ribosylation factor-like 8A binding to GDP 2012-12-31 2014-01-01 Xie, Y.,Ren, J.,Cheng, Z.,Qian, H. Structure of human ADP-ribosylation factor-like 8A binding to GDP To be Published 0 0 0 0 4L1B 24900786 Crystal Structure of p110alpha complexed with niSH2 of p85alpha 2013-06-03 2014-01-01 Zhao, Y.,Zhang, X.,Chen, Y.,Lu, S.,Peng, Y.,Wang, X.,Guo, C.,Zhou, A.,Zhang, J.,Luo, Y.,Shen, Q.,Ding, J.,Meng, L.,Zhang, J. Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett 2014 5 138 142 4L23 24900786 Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103 2013-06-04 2014-01-01 Zhao, Y.,Zhang, X.,Chen, Y.,Lu, S.,Peng, Y.,Wang, X.,Guo, C.,Zhou, A.,Zhang, J.,Luo, Y.,Shen, Q.,Ding, J.,Meng, L.,Zhang, J. Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett 2014 5 138 142 4L2Y 24900786 Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d 2013-06-05 2014-01-01 Zhao, Y.,Zhang, X.,Chen, Y.,Lu, S.,Peng, Y.,Wang, X.,Guo, C.,Zhou, A.,Zhang, J.,Luo, Y.,Shen, Q.,Ding, J.,Meng, L.,Zhang, J. Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett 2014 5 138 142 4LJL 24369431 Structural insights into the unique single-stranded DNA binding mode of DNA processing protein A from Helicobacter pylori 2013-07-05 2014-01-01 Wang, W.,Ding, J.,Zhang, Y.,Hu, Y.,Wang, D.C. Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res. 2014 42 3478 3491 4MPZ Crystal structure of TCP10c domain of Drosophila melanogaster Sas-4 2013-09-14 2014-01-01 Zheng, X.,Gooi, L.M.,Wason, A.,Gabriel, E.,Mehrjardi, N.,Yang, Q.,Zhang, X.,Debec, A.,Basiri, M.,Avidor-Reiss, T.,Pozniakovsky, A.,Poser, I.,Hyman, A.,Li, H.,Gopalakrishnan, J. The conserved TCP domain of Sas-4/CPAP is essential for Peri-centriolar material tethering during centrosome biogenesis Proc.Natl.Acad.Sci.USA 2014 0 0 0 4LNQ 24419611 Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA 2013-07-12 2014-01-08 Li, H.,Wang, J.,Wang, J.,Cao, L.S.,Wang, Z.X.,Wu, J.W. Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling. Acta Crystallogr F Struct Biol 2014 70 21 29 4N0O 24369429 Complex structure of Arterivirus nonstructural protein 10 (helicase) with DNA 2013-10-02 2014-01-08 Deng, Z.,Lehmann, K.C.,Li, X.,Feng, C.,Wang, G.,Zhang, Q.,Qi, X.,Yu, L.,Zhang, X.,Feng, W.,Wu, W.,Gong, P.,Tao, Y.,Posthuma, C.C.,Snijder, E.J.,Gorbalenya, A.E.,Chen, Z. Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res. 2014 42 3464 3477 4N9F Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex 2013-10-21 2014-01-08 Guo, Y.Y.,Dong, L.Y.,Qiu, X.L.,Wang, Y.S.,Zhang, B.L.,Liu, H.N.,Yu, Y.,Zang, Y.,Yang, M.J.,Huang, Z.W. Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif Nature 2014 505 229 233 4IYR 24419379 Crystal structure of full-length caspase-6 zymogen 2013-01-29 2014-01-15 Cao, Q.,Wang, X.J.,Li, L.F.,Su, X.D. The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays. Acta Crystallogr.,Sect.D 2014 70 58 67 4LA2 24395783 Crystal structure of dimethylsulphoniopropionate (DMSP) lyase DddQ 2013-06-19 2014-01-15 Li, C.,Wei, T.,Zhang, S.,Chen, X.,Gao, X.,Wang, P.,Xie, B.,Su, H.,Qin, Q.,Zhang, X.,Yu, J.,Zhang, H.,Zhou, B.,Yang, G.,Zhang, Y. Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide Proc.Natl.Acad.Sci.USA 2014 111 1026 1031 4LA3 24395783 Crystal structure of dimethylsulphoniopropionate (DMSP) lyase DddQ Y131A in complex with DMSP 2013-06-19 2014-01-15 Li, C.,Wei, T.,Zhang, S.,Chen, X.,Gao, X.,Wang, P.,Xie, B.,Su, H.,Qin, Q.,Zhang, X.,Yu, J.,Zhang, H.,Zhou, B.,Yang, G.,Zhang, Y. Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide Proc.Natl.Acad.Sci.USA 2014 111 1026 1031 4LGI 24419377 N-terminal truncated NleC structure 2013-06-28 2014-01-15 Li, W.,Liu, Y.,Sheng, X.,Yin, P.,Hu, F.,Liu, Y.,Chen, C.,Li, Q.,Yan, C.,Wang, J. Structure and mechanism of a type III secretion protease, NleC Acta Crystallogr.,Sect.D 2014 70 40 47 4LGJ 24419377 Crystal structure and mechanism of a type III secretion protease 2013-06-28 2014-01-15 Li, W.,Liu, Y.,Sheng, X.,Yin, P.,Hu, F.,Liu, Y.,Chen, C.,Li, Q.,Yan, C.,Wang, J. Structure and mechanism of a type III secretion protease, NleC Acta Crystallogr.,Sect.D 2014 70 40 47 4N41 24374628 Structure of Thermus thermophilus Argonaute bound to guide DNA and 15-mer target DNA 2013-10-08 2014-01-15 Sheng, G.,Zhao, H.,Wang, J.,Rao, Y.,Tian, W.,Swarts, D.C.,van der Oost, J.,Patel, D.J.,Wang, Y. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA 2014 111 652 657 4N76 24374628 Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+ 2013-10-15 2014-01-15 Sheng, G.,Zhao, H.,Wang, J.,Rao, Y.,Tian, W.,Swarts, D.C.,van der Oost, J.,Patel, D.J.,Wang, Y. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA 2014 111 652 657 4NCA 24374628 Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+ 2013-10-24 2014-01-15 Sheng, G.,Zhao, H.,Wang, J.,Rao, Y.,Tian, W.,Swarts, D.C.,van der Oost, J.,Patel, D.J.,Wang, Y. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA 2014 111 652 657 4NCB 24374628 Structure of Thermus thermophilus Argonaute bound to guide DNA and 19-mer target DNA with Mg2+ 2013-10-24 2014-01-15 Sheng, G.,Zhao, H.,Wang, J.,Rao, Y.,Tian, W.,Swarts, D.C.,van der Oost, J.,Patel, D.J.,Wang, Y. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA 2014 111 652 657 4O9B 24069340 The Structure of CC1-IH in human STIM1. 2014-01-02 2014-01-15 Cui, B.,Yang, X.,Li, S.,Lin, Z.,Wang, Z.,Dong, C.,Shen, Y. The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. Plos One 2013 8 0 0 4IFS Crystal structure of the hSSRP1 Middle domain 2012-12-15 2014-01-29 Zhang, W.J.,Zeng, F.X.,Shao, C.,Liu, Y.W.,Niu, L.W.,Li, X.,Teng, M.K. Crystal structure of the hSSRP1 Middle domain To be Published 0 0 0 0 4IK9 23549615 High resolution structure of GCaMP3 dimer form 2 at pH 7.5 2012-12-25 2014-01-29 Chen, Y.,Song, X.,Ye, S.,Miao, L.,Zhu, Y.,Zhang, R.G.,Ji, G. Structural insight into enhanced calcium indicator GCaMP3 and GCaMPJ to promote further improvement. Protein Cell 2013 4 299 309 4IMB 25850764 Structure of strictosidine synthase in complex with 2-(1-methyl-1H-indol-3-yl)ethanamine 2013-01-02 2014-01-29 Zhu, H.,Kercmar, P.,Wu, F.,Rajendran, C.,Sun, L.,Wang, M.,Stockigt, J. Using Strictosidine Synthase to Prepare Novel Alkaloids. Curr.Med.Chem. 2015 0 0 0 4IT7 24781326 Crystal structure of Al-CPI 2013-01-17 2014-01-29 Mei, G.,Dong, J.,Li, Z.,Liu, S.,Liu, Y.,Sun, M.,Liu, G.,Su, Z.,Liu, J. Structural Basis for the Immunomodulatory Function of Cysteine Protease Inhibitor from Human Roundworm Ascaris lumbricoides. Plos One 2014 9 0 0 4K5Q 24448805 Crystal structure of CALB mutant DGLM from Candida antarctica 2013-04-15 2014-01-29 Xie, Y.,An, J.,Yang, G.,Wu, G.,Zhang, Y.,Cui, L.,Feng, Y. Enhanced enzyme kinetic stability by increasing rigidity within the active site. J.Biol.Chem. 2014 289 7994 8006 4K6G 24448805 Crystal structure of CALB from Candida antarctica 2013-04-15 2014-01-29 Xie, Y.,An, J.,Yang, G.,Wu, G.,Zhang, Y.,Cui, L.,Feng, Y. Enhanced enzyme kinetic stability by increasing rigidity within the active site. J.Biol.Chem. 2014 289 7994 8006 4K6H 24448805 Crystal structure of CALB mutant L278M from Candida antarctica 2013-04-15 2014-01-29 Xie, Y.,An, J.,Yang, G.,Wu, G.,Zhang, Y.,Cui, L.,Feng, Y. Enhanced enzyme kinetic stability by increasing rigidity within the active site. J.Biol.Chem. 2014 289 7994 8006 4K6K 24448805 Crystal structure of CALB mutant D223G from Candida antarctica 2013-04-16 2014-01-29 Xie, Y.,An, J.,Yang, G.,Wu, G.,Zhang, Y.,Cui, L.,Feng, Y. Enhanced enzyme kinetic stability by increasing rigidity within the active site. J.Biol.Chem. 2014 289 7994 8006 4KPY 24374628 DNA binding protein and DNA complex structure 2013-05-14 2014-01-29 Sheng, G.,Zhao, H.,Wang, J.,Rao, Y.,Tian, W.,Swarts, D.C.,van der Oost, J.,Patel, D.J.,Wang, Y. Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA 2014 111 652 657 3ZJ7 25140865 Crystal structure of strictosidine glucosidase in complex with inhibitor-1 2013-01-17 2014-02-05 Xia, L.,Lin, H.,Staniek, A.,Panjikar, S.,Ruppert, M.,Hilgers, P.,Williardt, J.,Rajendran, C.,Wang, M.,Warzecha, H.,Jager, V.,Stockigt, J. Ligand Structures of Synthetic Deoxa-Pyranosylamines with Raucaffricine and Strictosidine Glucosidases Provide Structural Insights Into Their Binding and Inhibitory Behaviours. J.Enzyme.Inhib.Med.Chem. 2015 30 472 0 3ZJ8 25140865 Crystal structure of strictosidine glucosidase in complex with inhibitor-2 2013-01-17 2014-02-05 Xia, L.,Lin, H.,Staniek, A.,Panjikar, S.,Ruppert, M.,Hilgers, P.,Williardt, J.,Rajendran, C.,Wang, M.,Warzecha, H.,Jager, V.,Stockigt, J. Ligand Structures of Synthetic Deoxa-Pyranosylamines with Raucaffricine and Strictosidine Glucosidases Provide Structural Insights Into Their Binding and Inhibitory Behaviours. J.Enzyme.Inhib.Med.Chem. 2015 30 472 0 4IK1 23549615 High resolution structure of GCaMPJ at pH 8.5 2012-12-25 2014-02-05 Chen, Y.,Song, X.,Ye, S.,Miao, L.,Zhu, Y.,Zhang, R.G.,Ji, G. Structural insight into enhanced calcium indicator GCaMP3 and GCaMPJ to promote further improvement. Protein Cell 2013 4 299 309 4JUR 24023903 Crystal structure of the effector Tae4 from Salmonella typhimurium in complex with the immunity Tai4 from Enterobacter cloacae 2013-03-25 2014-02-05 Zhang, H.,Gao, Z.Q.,Wei, Y.,Xu, J.H.,Dong, Y.H. Insights into the cross-immunity mechanism within effector families of bacteria type VI secretion system from the structure of StTae4-EcTai4 complex Plos One 2013 8 0 0 4KB5 24248472 Crystal structure of MycP1 from Mycobacterium smegmatis 2013-04-23 2014-02-05 Sun, D.,Liu, Q.,He, Y.,Wang, C.,Wu, F.,Tian, C.,Zang, J. The putative propeptide of MycP1 in mycobacterial type VII secretion system does not inhibit protease activity but improves protein stability. Protein Cell 2013 4 921 931 4N43 24352461 Human enterovirus 71 uncoating intermediate captured at atomic resolution 2013-10-08 2014-02-05 Lyu, K.,Ding, J.,Han, J.F.,Zhang, Y.,Wu, X.Y.,He, Y.L.,Qin, C.F.,Chen, R. Human enterovirus 71 uncoating captured at atomic resolution. J.Virol. 2014 88 3114 3126 4N53 24352461 Human enterovirus 71 uncoating intermediate captured at atomic resolution 2013-10-09 2014-02-05 Lyu, K.,Ding, J.,Han, J.F.,Zhang, Y.,Wu, X.Y.,He, Y.L.,Qin, C.F.,Chen, R. Human enterovirus 71 uncoating captured at atomic resolution. J.Virol. 2014 88 3114 3126 4O6Y 24449903 Crystal Structure of Cytochrome b561 2013-12-24 2014-02-05 Lu, P.,Ma, D.,Yan, C.,Gong, X.,Du, M.,Shi, Y. Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase Proc.Natl.Acad.Sci.USA 2014 111 1813 1818 4O79 24449903 Crystal Structure of Ascorbate-bound Cytochrome b561, crystal soaked in 1 M L-ascorbate for 10 minutes 2013-12-24 2014-02-05 Lu, P.,Ma, D.,Yan, C.,Gong, X.,Du, M.,Shi, Y. Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase Proc.Natl.Acad.Sci.USA 2014 111 1813 1818 4O7G 24449903 Crystal Structure of Ascorbate-bound Cytochrome b561, crystal soaked in 1 M L-ascorbate for 40 minutes 2013-12-24 2014-02-05 Lu, P.,Ma, D.,Yan, C.,Gong, X.,Du, M.,Shi, Y. Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase Proc.Natl.Acad.Sci.USA 2014 111 1813 1818 3W4R 24699639 Crystal structure of an insect chitinase from the Asian corn borer, Ostrinia furnacalis 2013-01-10 2014-02-12 Chen, L.,Liu, T.,Zhou, Y.,Chen, Q.,Shen, X.,Yang, Q. Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting Acta Crystallogr.,Sect.D 2014 70 932 942 4M1Z 24248472 Crystal structure of MycP1 with the N-terminal propeptide removed 2013-08-04 2014-02-12 Sun, D.M.,Liu, Q.,He, Y.,Wang, C.L.,Wu, F.M.,Tian, C.L.,Zang, J.Y. The putative propeptide of MycP1 in mycobacterial type VII secretion system does not inhibit protease activity but improves protein stability. Protein Cell 2013 4 921 931 4NK5 24407918 Crystal structure of FabI-NAD complex from Candidatus Liberibacter asiaticus 2013-11-12 2014-02-12 Jiang, L.,Gao, Z.,Li, Y.,Wang, S.,Dong, Y. Crystal structures and kinetic properties of enoyl-acyl carrier protein reductase I from Candidatus Liberibacter asiaticus. Protein Sci. 2014 23 366 377 4OBY 24474195 Crystal Structure of E.coli Arginyl-tRNA Synthetase and Ligand Binding Studies Revealed Key Residues in Arginine Recognition 2014-01-08 2014-02-12 Bi, K.,Zheng, Y.,Gao, F.,Dong, J.,Wang, J.,Wang, Y.,Gong, W. Crystal structure of E. coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition. Protein Cell 2014 5 151 159 4N1F 24418253 Crystal Structure of F88Y obelin mutant from Obelia longissima at 2.09 Angstrom resolution 2013-10-04 2014-02-19 Natashin, P.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins Febs J. 2014 281 1432 1445 4N1F 24418253 Crystal Structure of F88Y obelin mutant from Obelia longissima at 2.09 Angstrom resolution 2013-10-04 2014-02-19 Natashin, P.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins Febs J. 2014 281 1432 1445 4N1G 24418253 Crystal Structure of Ca(2+)- discharged F88Y obelin mutant from Obelia longissima at 1.50 Angstrom resolution 2013-10-04 2014-02-19 Natashin, P.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins Febs J. 2014 281 1432 1445 4N1G 24418253 Crystal Structure of Ca(2+)- discharged F88Y obelin mutant from Obelia longissima at 1.50 Angstrom resolution 2013-10-04 2014-02-19 Natashin, P.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins Febs J. 2014 281 1432 1445 4N9B 24433859 Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 2013-10-20 2014-02-19 Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.C.,Hua, R.,Li, G.,Liang, X.,Ma, X.,O'Brien, T.,Oh, A.,Skelton, N.J.,Wang, C.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhao, Q.,Zheng, X. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett. 2014 24 954 962 4N9D 24433859 Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 2013-10-20 2014-02-19 Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.C.,Hua, R.,Li, G.,Liang, X.,Ma, X.,O'Brien, T.,Oh, A.,Skelton, N.J.,Wang, C.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhao, Q.,Zheng, X. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett. 2014 24 954 962 4NOJ 24407422 Crystal structure of the mature form of asparaginyl endopeptidase (AEP)/Legumain activated at pH 3.5 2013-11-19 2014-02-19 Zhao, L.,Hua, T.,Crowley, C.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Hung, L.W.,Huang, W.,Liu, L.,Ye, K.,Ouyang, S.,Cheng, G.,Liu, Z.J. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014 24 344 358 4NOL 24407422 Crystal structure of proenzyme asparaginyl endopeptidase (AEP)/Legumain mutant D233A at pH 7.5 2013-11-19 2014-02-19 Zhao, L.,Hua, T.,Crowley, C.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Hung, L.W.,Huang, W.,Liu, L.,Ye, K.,Ouyang, S.,Cheng, G.,Liu, Z.J. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014 24 344 358 4NOM 24407422 Crystal structure of asparaginyl endopeptidase (AEP)/Legumain activated at pH 4.5 2013-11-19 2014-02-19 Zhao, L.,Hua, T.,Crowley, C.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Hung, L.W.,Huang, W.,Liu, L.,Ye, K.,Ouyang, S.,Cheng, G.,Liu, Z.J. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014 24 344 358 4NSX 24466140 Crystal Structure of the Utp21 tandem WD Domain 2013-11-29 2014-02-19 Zhang, C.,Lin, J.,Liu, W.,Chen, X.,Chen, R.,Ye, K. Structure of Utp21 Tandem WD Domain Provides Insight into the Organization of the UTPB Complex Involved in Ribosome Synthesis Plos One 2014 9 0 0 4GO3 Crystal structure of PnpE from Pseudomonas sp. WBC-3 2012-08-18 2014-02-26 Su, J.,Zhang, C.,Liu, S.,Zhu, D.,Gu, L. Crystal structure of PnpE from Pseudomonas sp. WBC-3 To be Published 0 0 0 0 4JCM Crystal structure of Gamma-CGTASE from Alkalophilic bacillus clarkii at 1.65 Angstrom resolution 2013-02-22 2014-02-26 Wu, L.,Yang, D.,Li, J.,Zhou, J.,Wu, J. The Crystal Structure of Gamma-Cgtase from Alkalophilic Bacillus Clarkii at 1.65 Angstrom Resolution. To be Published 0 0 0 0 4LN0 24525233 Crystal structure of the VGLL4-TEAD4 complex 2013-07-11 2014-02-26 Jiao, S.,Wang, H.,Shi, Z.,Dong, A.,Zhang, W.,Song, X.,He, F.,Wang, Y.,Zhang, Z.,Wang, W.,Wang, X.,Guo, T.,Li, P.,Zhao, Y.,Ji, H.,Zhang, L.,Zhou, Z. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell 2014 25 166 180 4LTY 24531464 Crystal Structure of E.coli SbcD at 1.8 A Resolution 2013-07-24 2014-02-26 Liu, S.,Tian, L.F.,Liu, Y.P.,An, X.M.,Tang, Q.,Yan, X.X.,Liang, D.C. Structural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repair. Acta Crystallogr.,Sect.D 2014 70 299 309 4MG2 ALKBH2 F102A cross-linked to undamaged dsDNA 2013-08-28 2014-02-26 Chen, B.,Gan, J.,Yang, C.G. The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin Sci China Chem 2014 57 307 313 4MGT ALKBH2 R110A cross-linked to undamaged dsDNA 2013-08-28 2014-02-26 Chen, B.,Gan, J.,Yang, C.G. The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin Sci China Chem 2014 57 307 313 4NN2 Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein PHF6 2013-11-16 2014-02-26 Liu, Z.,Li, F.,Zhang, J.,Mei, Y.,Wu, J.,Shi, Y. Crystal Structure of the second extended PHD domain of human PHF6 protein J.Biol.Chem. 2014 0 0 0 4NSC 24514027 Crystal Structure of CBARA1 in the Apo-form 2013-11-28 2014-02-26 Wang, L.,Yang, X.,Li, S.,Wang, Z.,Liu, Y.,Feng, J.,Zhu, Y.,Shen, Y. Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. Embo J. 2014 33 594 604 4NSD 24514027 Crystal Structure of CBARA1 in the Ca2+ Binding Form 2013-11-28 2014-02-26 Wang, L.,Yang, X.,Li, S.,Wang, Z.,Liu, Y.,Feng, J.,Zhu, Y.,Shen, Y. Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. Embo J. 2014 33 594 604 4JGD Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016 2013-03-01 2014-03-05 Zhu, L.,Zhu, J.,Ren, X.,Li, H. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016 TO BE PUBLISHED 0 0 0 0 4JNA 24553401 Crystal structure of the DepH complex with dimethyl-FK228 2013-03-14 2014-03-05 Li, J.,Wang, C.,Zhang, Z.M.,Cheng, Y.Q.,Zhou, J. The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep 2014 4 4145 4145 4JNA 24553401 Crystal structure of the DepH complex with dimethyl-FK228 2013-03-14 2014-03-05 Li, J.,Wang, C.,Zhang, Z.M.,Cheng, Y.Q.,Zhou, J. The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep 2014 4 4145 4145 4JQE 24531484 Crystal structure of scCK2 alpha in complex with AMPPN 2013-03-20 2014-03-05 Liu, H.,Wang, H.,Teng, M.,Li, X. The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D 2014 70 501 513 4JR7 24531484 Crystal structure of scCK2 alpha in complex with GMPPNP 2013-03-21 2014-03-05 Liu, H.,Wang, H.,Teng, M.,Li, X. The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D 2014 70 501 513 4LFI 24531484 Crystal structure of scCK2 alpha in complex with GMPPNP 2013-06-27 2014-03-05 Liu, H.,Wang, H.,Teng, M.,Li, X. The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D 2014 70 501 513 4N4H 24590075 Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.1K36me3 2013-10-08 2014-03-05 Wen, H.,Li, Y.,Xi, Y.,Jiang, S.,Stratton, S.,Peng, D.,Tanaka, K.,Ren, Y.,Xia, Z.,Wu, J.,Li, B.,Barton, M.C.,Li, W.,Li, H.,Shi, X. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Nature 2014 508 263 268 4N4I 24590075 Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.3K36me3 2013-10-08 2014-03-05 Wen, H.,Li, Y.,Xi, Y.,Jiang, S.,Stratton, S.,Peng, D.,Tanaka, K.,Ren, Y.,Xia, Z.,Wu, J.,Li, B.,Barton, M.C.,Li, W.,Li, H.,Shi, X. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Nature 2014 508 263 268 4NSQ 24423233 Crystal structure of PCAF 2013-11-28 2014-03-05 Shi, S.,Lin, J.,Cai, Y.,Yu, J.,Hong, H.,Ji, K.,Downey, J.S.,Lu, X.,Chen, R.,Han, J.,Han, A. Dimeric structure of p300/CBP associated factor. Bmc Struct.Biol. 2014 14 2 2 4MRX 24598741 Crystal Structure of Y138F obelin mutant from Obelia longissima at 1.72 Angstrom resolution 2013-09-17 2014-03-12 Natashin, P.V.,Ding, W.,Eremeeva, E.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Structures of the Ca2+-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction. Acta Crystallogr.,Sect.D 2014 70 720 732 4MRX 24598741 Crystal Structure of Y138F obelin mutant from Obelia longissima at 1.72 Angstrom resolution 2013-09-17 2014-03-12 Natashin, P.V.,Ding, W.,Eremeeva, E.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Structures of the Ca2+-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction. Acta Crystallogr.,Sect.D 2014 70 720 732 4MRY 24598741 Crystal Structure of Ca(2+)- discharged Y138F obelin mutant from Obelia longissima at 1.30 Angstrom resolution 2013-09-17 2014-03-12 Natashin, P.V.,Ding, W.,Eremeeva, E.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Structures of the Ca2+-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction. Acta Crystallogr.,Sect.D 2014 70 720 732 4MRY 24598741 Crystal Structure of Ca(2+)- discharged Y138F obelin mutant from Obelia longissima at 1.30 Angstrom resolution 2013-09-17 2014-03-12 Natashin, P.V.,Ding, W.,Eremeeva, E.V.,Markova, S.V.,Lee, J.,Vysotski, E.S.,Liu, Z.J. Structures of the Ca2+-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction. Acta Crystallogr.,Sect.D 2014 70 720 732 3WP0 24513855 Crystal structure of Dlg GK in complex with a phosphor-Lgl2 peptide 2014-01-08 2014-03-19 Zhu, J.,Shang, Y.,Wan, Q.,Xia, Y.,Chen, J.,Du, Q.,Zhang, M. Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl Cell Res. 2014 24 451 463 3WP1 24513855 Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl 2014-01-08 2014-03-19 Zhu, J.,Shang, Y.,Wan, Q.,Xia, Y.,Chen, J.,Du, Q.,Zhang, M. Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl Cell Res. 2014 24 451 463 4NRO 24616105 Crystal structure of human ALKBH5 in complex with alpha-ketoglutarate 2013-11-27 2014-03-19 Feng, C.,Liu, Y.,Wang, G.,Deng, Z.,Zhang, Q.,Wu, W.,Tong, Y.,Cheng, C.,Chen, Z. Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition J.Biol.Chem. 2014 289 11571 11583 4O7X 24616105 Crystal structure of human ALKBH5 in complex with Mn2+ 2013-12-26 2014-03-19 Feng, C.,Liu, Y.,Wang, G.,Deng, Z.,Zhang, Q.,Wu, W.,Tong, Y.,Cheng, C.,Chen, Z. Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition J.Biol.Chem. 2014 289 11571 11583 4JS3 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 2013-03-22 2014-03-26 Zhu, L.,Li, H.,Zhu, J.,Ren, X. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 TO BE PUBLISHED 0 0 0 0 4JTS Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 072 2013-03-24 2014-03-26 Zhu, L.,Li, H.,Zhu, J.,Ren, X. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 To be Published 0 0 0 0 4JTT Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 066 2013-03-24 2014-03-26 Zhu, L.,Li, H.,Zhu, J.,Ren, X. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 TO BE PUBLISHED 0 0 0 0 4JTU Crystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue 2013-03-24 2014-03-26 Zhu, L.,Li, H.,Zhu, J.,Ren, X. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 To be Published 0 0 0 0 4M58 24366337 Crystal Structure of an transition metal transporter 2013-08-08 2014-03-26 Yu, Y.,Zhou, M.Z.,Kirsch, F.,Xu, C.Q.,Zhang, L.,Wang, Y.,Jiang, Z.,Wang, N.,Li, J.,Eitinger, T.,Yang, M.J. Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters Cell Res. 2014 24 267 277 4M5B 24366337 Crystal Structure of an Truncated Transition Metal Transporter 2013-08-08 2014-03-26 Yu, Y.,Zhou, M.Z.,Kirsch, F.,Xu, C.Q.,Zhang, L.,Wang, Y.,Jiang, Z.,Wang, N.,Li, J.,Eitinger, T.,Yang, M.J. Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters Cell Res. 2014 24 267 277 4M5C 24366337 Crystal Structure of an Truncated Transition metal Transporter 2013-08-08 2014-03-26 Yu, Y.,Zhou, M.Z.,Kirsch, F.,Xu, C.Q.,Zhang, L.,Wang, Y.,Jiang, Z.,Wang, N.,Li, J.,Eitinger, T.,Yang, M.J. Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters Cell Res. 2014 24 267 277 4MZF 24589551 Crystal structure of human Spindlin1 bound to histone H3(K4me3-R8me2a) peptide 2013-09-30 2014-03-26 Su, X.,Zhu, G.,Ding, X.,Lee, S.Y.,Dou, Y.,Zhu, B.,Wu, W.,Li, H. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1 Genes Dev. 2014 28 622 636 4MZG 24589551 Crystal structure of human Spindlin1 bound to histone H3K4me3 peptide 2013-09-30 2014-03-26 Su, X.,Zhu, G.,Ding, X.,Lee, S.Y.,Dou, Y.,Zhu, B.,Wu, W.,Li, H. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1 Genes Dev. 2014 28 622 636 4MZH 24589551 Crystal structure of human Spindlin1 bound to histone H3(K4me3-R8me2s) peptide 2013-09-30 2014-03-26 Su, X.,Zhu, G.,Ding, X.,Lee, S.Y.,Dou, Y.,Zhu, B.,Wu, W.,Li, H. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1 Genes Dev. 2014 28 622 636 4PQ0 Crystal structure of POB3 middle domain at 1.65A 2014-02-28 2014-03-26 Liu, H. Crystal structure of POB3 middle domain at 1.65A TO BE PUBLISHED 0 0 0 0 4JYY Crystal structure of the azide and iron substituted Clostrium difficile SOD2 complex 2013-04-01 2014-04-02 Li, W.,Ying, T.L.,Wang, C.L.,Zhao, Y.,Wang, H.F.,Tan, X.S. Crystal structure of the azide and iron substituted Clostrium difficile SOD2 complex To be Published 0 0 0 0 4JZ2 Crystal structure of Co ion substituted SOD2 from Clostridium difficile 2013-04-02 2014-04-02 Li, W.,Ying, T.L.,Wang, C.L.,Zhao, Y.,Wang, H.F.,Tan, X.S. Crystal structure of Co ion substituted SOD2 from Clostridium difficile To be Published 0 0 0 0 4JZG Crystal structure of a single cambialistic SOD2 occupied by Manganese ion from Clostridium difficile 2013-04-02 2014-04-02 Li, W.,Wang, C.L.,Zhao, Y.,Wang, H.F.,Tan, S.X. Crystal structure of a single cambialistic SOD2 occupied by Manganese ion from Clostridium difficile To be Published 0 0 0 0 3WKZ 24699639 Crystal Structure of the Ostrinia furnacalis Group I Chitinase catalytic domain E148Q mutant 2013-11-05 2014-04-09 Chen, L.,Liu, T.,Zhou, Y.,Chen, Q.,Shen, X.,Yang, Q. Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D 2014 70 932 942 3WL0 24699639 Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain E148A mutant in complex with a(GlcNAc)2 2013-11-05 2014-04-09 Chen, L.,Liu, T.,Zhou, Y.,Chen, Q.,Shen, X.,Yang, Q. Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D 2014 70 932 942 3WL1 24699639 Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with reaction products (GlcNAc)2,3 2013-11-05 2014-04-09 Chen, L.,Liu, T.,Zhou, Y.,Chen, Q.,Shen, X.,Yang, Q. Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D 2014 70 932 942 4HND 24675427 Crystal structure of the catalytic domain of Selenomethionine substituted human PI4KIIalpha in complex with ADP 2012-10-19 2014-04-09 Zhou, Q.,Li, J.,Yu, H.,Zhai, Y.,Gao, Z.,Liu, Y.,Pang, X.,Zhang, L.,Schulten, K.,Sun, F.,Chen, C. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha. Nat Commun 2014 5 3552 3552 4HNE 24675427 Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP 2012-10-19 2014-04-09 Zhou, Q.,Li, J.,Yu, H.,Zhai, Y.,Gao, Z.,Liu, Y.,Pang, X.,Zhang, L.,Schulten, K.,Sun, F.,Chen, C. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha. Nat Commun 2014 5 3552 3552 4JN9 24553401 Crystal structure of the DepH 2013-03-14 2014-04-09 Li, J.,Wang, C.,Zhang, Z.M.,Cheng, Y.Q.,Zhou, J. The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep 2014 4 4145 4145 4JN9 24553401 Crystal structure of the DepH 2013-03-14 2014-04-09 Li, J.,Wang, C.,Zhang, Z.M.,Cheng, Y.Q.,Zhou, J. The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep 2014 4 4145 4145 4KN8 24256105 Crystal structure of Bs-TpNPPase 2013-05-09 2014-04-09 Guo, Z.,Wang, F.,Shen, T.,Huang, J.,Wang, Y.,Ji, C. Crystal Structure of Thermostable p-nitrophenylphosphatase from Bacillus Stearothermophilus (Bs-TpNPPase) PROTEIN PEPT.LETT. 2014 21 483 489 4NFT 24613878 Crystal structure of human lnkH2B-h2A.Z-Anp32e 2013-11-01 2014-04-09 Mao, Z.,Pan, L.,Wang, W.,Sun, J.,Shan, S.,Dong, Q.,Liang, X.,Dai, L.,Ding, X.,Chen, S.,Zhang, Z.,Zhu, B.,Zhou, Z. Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z Cell Res. 2014 24 389 399 4NS5 24675531 Crystal structure of human BS69 Bromo-Zinc finger-PWWP 2013-11-28 2014-04-09 Wang, J.,Qin, S.,Li, F.,Li, S.,Zhang, W.,Peng, J.,Zhang, Z.,Gong, Q.,Wu, J.,Shi, Y. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding. Cell Res. 2014 24 890 893 4NS5 24675531 Crystal structure of human BS69 Bromo-Zinc finger-PWWP 2013-11-28 2014-04-09 Wang, J.,Qin, S.,Li, F.,Li, S.,Zhang, W.,Peng, J.,Zhang, Z.,Gong, Q.,Wu, J.,Shi, Y. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding. Cell Res. 2014 24 890 893 4NT4 24699734 Crystal structure of the kinase domain of Gilgamesh isoform I from Drosophila melanogaster 2013-11-30 2014-04-09 Han, N.,Chen, C.,Shi, Z.,Cheng, D. Structure of the kinase domain of Gilgamesh from Drosophila melanogaster Acta Crystallogr.,Sect.F 2014 70 438 443 4P7I 24706749 Crystal structure of the Merlin FERM/DCAF1 complex 2014-03-27 2014-04-09 Li, Y.,Wei, Z.,Zhang, J.,Yang, Z.,Zhang, M. Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1. J.Biol.Chem. 2014 289 14674 14681 4N75 24619089 Structural Basis of BamA-mediate Outer Membrane Protein Biogenesis 2013-10-14 2014-04-16 Ni, D.,Wang, Y.,Yang, X.,Zhou, H.,Hou, X.,Cao, B.,Lu, Z.,Zhao, X.,Yang, K.,Huang, Y. Structural and functional analysis of the beta-barrel domain of BamA from Escherichia coli. Faseb J. 2014 28 2677 2685 4NID 24596302 Crystal structure of AlkB protein with cofactors bound to dsDNA containing m6A 2013-11-06 2014-04-16 Zhu, C.,Yi, C. Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues. Angew.Chem.Int.Ed.Engl. 2014 53 3659 3662 4NIG 24596302 Crystal structure of AlkB D135I/E136H mutant protein with cofactors bound to dsDNA containing m6A/A 2013-11-06 2014-04-16 Zhu, C.,Yi, C. Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues. Angew.Chem.Int.Ed.Engl. 2014 53 3659 3662 4NIH 24596302 Crystal structure of AlkB E136L mutant protein with cofactors bound to dsDNA containing m6A/A 2013-11-06 2014-04-16 Zhu, C.,Yi, C. Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues. Angew.Chem.Int.Ed.Engl. 2014 53 3659 3662 4NII 24596302 Crystal structure of AlkB D135I mutant protein with cofactors bound to dsDNA containing m6A/A 2013-11-06 2014-04-16 Zhu, C.,Yi, C. Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues. Angew.Chem.Int.Ed.Engl. 2014 53 3659 3662 4OWT 24630995 Structural basis of SOSS1 complex assembly 2014-02-03 2014-04-16 Ren, W.,Chen, H.,Sun, Q.,Tang, X.,Lim, S.C.,Huang, J.,Song, H. Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep 2014 6 982 991 4OWW 24630995 Structural basis of SOSS1 in complex with a 35nt ssDNA 2014-02-04 2014-04-16 Ren, W.,Chen, H.,Sun, Q.,Tang, X.,Lim, S.C.,Huang, J.,Song, H. Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep 2014 6 982 991 4OWX 24630995 Structural basis of SOSS1 in complex with a 12nt ssDNA 2014-02-04 2014-04-16 Ren, W.,Chen, H.,Sun, Q.,Tang, X.,Lim, S.C.,Huang, J.,Song, H. Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep 2014 6 982 991 4M5E 24724564 Tse3 structure 2013-08-08 2014-04-23 Lu, D.,Shang, G.,Zhang, H.,Yu, Q.,Cong, X.,Yuan, J.,He, F.,Zhu, C.,Zhao, Y.,Yin, K.,Chen, Y.,Hu, J.,Zhang, X.,Yuan, Z.,Xu, S.,Hu, W.,Cang, H.,Gu, L. Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol. 2014 92 1092 1112 4M5F 24724564 complex structure of Tse3-Tsi3 2013-08-08 2014-04-23 Lu, D.,Shang, G.,Zhang, H.,Yu, Q.,Cong, X.,Yuan, J.,He, F.,Zhu, C.,Zhao, Y.,Yin, K.,Chen, Y.,Hu, J.,Zhang, X.,Yuan, Z.,Xu, S.,Hu, W.,Cang, H.,Gu, L. Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol. 2014 92 1092 1112 4MXD 24737327 1.45 angstronm crystal structure of E.coli 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH) 2013-09-26 2014-04-23 Sun, Y.,Yin, S.,Feng, Y.,Li, J.,Zhou, J.,Liu, C.,Zhu, G.,Guo, Z. Molecular basis of the general base catalysis of an alpha / beta-hydrolase catalytic triad. J.Biol.Chem. 2014 289 15867 15879 4MYD 24737327 1.37 Angstrom Crystal Structure of E. Coli 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (MenH) in complex with SHCHC 2013-09-27 2014-04-23 Sun, Y.,Yin, S.,Feng, Y.,Li, J.,Zhou, J.,Liu, C.,Zhu, G.,Guo, Z. Molecular basis of the general base catalysis of an alpha / beta-hydrolase catalytic triad. J.Biol.Chem. 2014 289 15867 15879 4MYS 24737327 1.4 Angstrom Crystal Structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase with SHCHC and Pyruvate 2013-09-28 2014-04-23 Sun, Y.,Yin, S.,Feng, Y.,Li, J.,Zhou, J.,Liu, C.,Zhu, G.,Guo, Z. Molecular basis of the general base catalysis of an alpha / beta-hydrolase catalytic triad. J.Biol.Chem. 2014 289 15867 15879 4N7S 24724564 Crystal structure of Tse3-Tsi3 complex with Zinc ion 2013-10-16 2014-04-23 Lu, D.,Shang, G.,Zhang, H.,Yu, Q.,Cong, X.,Yuan, J.,He, F.,Zhu, C.,Zhao, Y.,Yin, K.,Chen, Y.,Hu, J.,Zhang, X.,Yuan, Z.,Xu, S.,Hu, W.,Cang, H.,Gu, L. Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol. 2014 92 1092 1112 4N80 24724564 Crystal structure of Tse3-Tsi3 complex 2013-10-16 2014-04-23 Lu, D.,Shang, G.,Zhang, H.,Yu, Q.,Cong, X.,Yuan, J.,He, F.,Zhu, C.,Zhao, Y.,Yin, K.,Chen, Y.,Hu, J.,Zhang, X.,Yuan, Z.,Xu, S.,Hu, W.,Cang, H.,Gu, L. Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol. 2014 92 1092 1112 4N88 24724564 Crystal structure of Tse3-Tsi3 complex with calcium ion 2013-10-17 2014-04-23 Lu, D.,Shang, G.,Zhang, H.,Yu, Q.,Cong, X.,Yuan, J.,He, F.,Zhu, C.,Zhao, Y.,Yin, K.,Chen, Y.,Hu, J.,Zhang, X.,Yuan, Z.,Xu, S.,Hu, W.,Cang, H.,Gu, L. Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism Mol.Microbiol. 2014 92 1092 1112 4O1H 24733389 Crystal Structure of the regulatory domain of AmeGlnR 2013-12-16 2014-04-23 Lin, W.,Wang, Y.,Han, X.,Zhang, Z.,Wang, C.,Wang, J.,Yang, H.,Lu, Y.,Jiang, W.,Zhao, G.P.,Zhang, P. Atypical OmpR/PhoB Subfamily Response Regulator GlnR of Actinomycetes Functions as a Homodimer, Stabilized by the Unphosphorylated Conserved Asp-focused Charge Interactions J.Biol.Chem. 2014 289 15413 15425 4O1I 24733389 Crystal Structure of the regulatory domain of MtbGlnR 2013-12-16 2014-04-23 Lin, W.,Wang, Y.,Han, X.,Zhang, Z.,Wang, C.,Wang, J.,Yang, H.,Lu, Y.,Jiang, W.,Zhao, G.P.,Zhang, P. Atypical OmpR/PhoB Subfamily Response Regulator GlnR of Actinomycetes Functions as a Homodimer, Stabilized by the Unphosphorylated Conserved Asp-focused Charge Interactions J.Biol.Chem. 2014 289 15413 15425 3WA8 Crystal structure of M. ruber CasB 2013-04-28 2014-04-30 Yuan, Y.A.,Yuan, Z. Structural insights into crRNA G-rich sequence binding and R-loop formation facilitated by Meiothermus ruber CasB To be Published 0 0 0 0 4L0G Crystal Structure of a GH48 cellobiohydrolase from Caldicellulosiruptor bescii 2013-05-31 2014-04-30 Jiao, A.,Bai, A.,Yan, F.,Geng, W. Crystallization and preliminary X-ray analysis of a processive cellobiohydrolase CbCBH48A from Caldicellulosiruptor bescii to be published 0 0 0 0 4OLT 24766439 Chitosanase complex structure 2014-01-25 2014-04-30 Lyu, Q.,Wang, S.,Xu, W.,Han, B.,Liu, W.,Jones, D.N.,Liu, W. Structural insights into the substrate-binding mechanism for a novel chitosanase. Biochem.J. 2014 461 335 345 4L4O The crystal structure of CbXyn10B in native form 2013-06-08 2014-05-07 An, J.,Feng, Y.,Wu, G. Crystal structure of CbXyn10B from Caldicellulosiruptor bescii and its mutant(E139A) in complex with xylotriose To be Published 0 0 0 0 4L4P the mutant(E139A) structure in complex with xylotriose 2013-06-08 2014-05-07 An, J.,Feng, Y.,Wu, G. Crystal structure of CbXyn10B from Caldicellulosiruptor bescii and its mutant(E139A) in complex with xylotriose To be Published 0 0 0 0 4LCZ 24482437 Crystal structure of a multilayer-packed major light-harvesting complex 2013-06-24 2014-05-07 Wan, T.,Li, M.,Zhao, X.,Zhang, J.,Liu, Z.,Chang, W. Crystal structure of a multilayer packed major light-harvesting complex: implications for grana stacking in higher plants. Mol Plant 2014 7 916 919 4LZX 24787902 Complex of IQCG and Ca2+-free CaM 2013-08-01 2014-05-07 Chen, L.T.,Liang, W.X.,Chen, S.,Li, R.K.,Tan, J.L.,Xu, P.F.,Luo, L.F.,Wang, L.,Yu, S.H.,Meng, G.,Li, K.K.,Liu, T.X.,Chen, Z.,Chen, S.J. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish Nat Commun 2014 5 3811 3811 4M1L 24787902 Complex of IQCG and Ca2+-bound CaM 2013-08-03 2014-05-07 Chen, L.T.,Liang, W.X.,Chen, S.,Li, R.K.,Tan, J.L.,Xu, P.F.,Luo, L.F.,Wang, L.,Yu, S.H.,Meng, G.,Li, K.K.,Liu, T.X.,Chen, Z.,Chen, S.J. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish Nat Commun 2014 5 3811 3811 4PW5 24813944 structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I 2014-03-18 2014-05-07 Zhou, T.,Xiong, J.,Wang, M.,Yang, N.,Wong, J.,Zhu, B.,Xu, R.M. Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell 2014 54 879 886 4PW6 24813944 structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II 2014-03-18 2014-05-07 Zhou, T.,Xiong, J.,Wang, M.,Yang, N.,Wong, J.,Zhu, B.,Xu, R.M. Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell 2014 54 879 886 4L0K 24733184 Crystal structure of a type II restriction endonuclease 2013-05-31 2014-05-14 Zhuo, W.,Lai, X.,Zhang, L.,Chan, S.H.,Li, F.,Zhu, Z.,Yang, M.,Sun, D. Elimination of inter-domain interactions increases the cleavage fidelity of the restriction endonuclease DraIII. Protein Cell 2014 5 357 368 4N7R 24753615 Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its binding protein 2013-10-16 2014-05-14 Zhao, A.,Fang, Y.,Chen, X.,Zhao, S.,Dong, W.,Lin, Y.,Gong, W.,Liu, L. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein Proc.Natl.Acad.Sci.USA 2014 111 6630 6635 4N7R 24753615 Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its binding protein 2013-10-16 2014-05-14 Zhao, A.,Fang, Y.,Chen, X.,Zhao, S.,Dong, W.,Lin, Y.,Gong, W.,Liu, L. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein Proc.Natl.Acad.Sci.USA 2014 111 6630 6635 4N7R 24753615 Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its binding protein 2013-10-16 2014-05-14 Zhao, A.,Fang, Y.,Chen, X.,Zhao, S.,Dong, W.,Lin, Y.,Gong, W.,Liu, L. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein Proc.Natl.Acad.Sci.USA 2014 111 6630 6635 4KQE 26797133 The mutant structure of the human glycyl-tRNA synthetase E71G 2013-05-15 2014-05-21 Deng, X.,Qin, X.,Chen, L.,Jia, Q.,Zhang, Y.,Zhang, Z.,Lei, D.,Ren, G.,Zhou, Z.,Wang, Z.,Li, Q.,Xie, W. Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis J.Biol.Chem. 2016 291 5740 5752 4KR2 24898252 Glycyl-tRNA synthetase in complex with tRNA-Gly 2013-05-16 2014-05-21 Qin, X.,Hao, Z.,Tian, Q.,Zhang, Z.,Zhou, C.,Xie, W. Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation J.Biol.Chem. 2014 289 20359 20369 4KR3 24898252 Glycyl-tRNA synthetase mutant E71G in complex with tRNA-Gly 2013-05-16 2014-05-21 Qin, X.,Hao, Z.,Tian, Q.,Zhang, Z.,Zhou, C.,Xie, W. Cocrystal Structures of Glycyl-tRNA Synthetase in Complex with tRNA Suggest Multiple Conformational States in Glycylation J.Biol.Chem. 2014 289 20359 20369 4NQJ 24722452 Structure of coiled-coil domain 2013-11-25 2014-05-21 Li, Y.,Wu, H.,Wu, W.,Zhuo, W.,Liu, W.,Zhang, Y.,Cheng, M.,Chen, Y.G.,Gao, N.,Yu, H.,Wang, L.,Li, W.,Yang, M. Structural insights into the TRIM family of ubiquitin E3 ligases. Cell Res. 2014 24 762 765 4PYP 24847886 Crystal structure of the human glucose transporter GLUT1 2014-03-27 2014-05-21 Deng, D.,Xu, C.,Sun, P.C.,Wu, J.P.,Yan, C.Y.,Hu, M.X.,Yan, N. Crystal structure of the human glucose transporter GLUT1 Nature 2014 510 121 125 4Q5Y 24810300 Crystal structure of extended-Tudor 10-11 of Drosophila melanogaster 2014-04-18 2014-05-21 Ren, R.,Liu, H.,Wang, W.,Wang, M.,Yang, N.,Dong, Y.H.,Gong, W.,Lehmann, R.,Xu, R.M. Structure and domain organization of Drosophila Tudor Cell Res. 2014 24 1146 1149 3WQV 24828498 Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)5 2014-02-03 2014-05-28 Chen, L.,Zhou, Y.,Qu, M.,Zhao, Y.,Yang, Q. Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors. J.Biol.Chem. 2014 289 17932 17940 3WQW 24828498 Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)6 2014-02-03 2014-05-28 Chen, L.,Zhou, Y.,Qu, M.,Zhao, Y.,Yang, Q. Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors. J.Biol.Chem. 2014 289 17932 17940 4LN2 24878663 The second SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin 2013-07-11 2014-05-28 Zhao, D.,Wang, X.,Peng, J.,Wang, C.,Li, F.,Sun, Q.,Zhang, Y.,Zhang, J.,Cai, G.,Zuo, X.,Wu, J.,Shi, Y.,Zhang, Z.,Gong, Q. Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin J.Struct.Biol. 2014 187 194 205 4LNP 24878663 The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin 2013-07-11 2014-05-28 Zhao, D.,Wang, X.,Peng, J.,Wang, C.,Li, F.,Sun, Q.,Zhang, Y.,Zhang, J.,Cai, G.,Zuo, X.,Wu, J.,Shi, Y.,Zhang, Z.,Gong, Q. Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin J.Struct.Biol. 2014 187 194 205 4NFB 24843130 Structure of paired immunoglobulin-like type 2 receptor (PILR ) 2013-10-31 2014-05-28 Lu, Q.,Lu, G.,Qi, J.,Wang, H.,Xuan, Y.,Wang, Q.,Li, Y.,Zhang, Y.,Zheng, C.,Fan, Z.,Yan, J.,Gao, G.F. PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid Proc.Natl.Acad.Sci.USA 2014 111 8221 8226 4NFC 24843130 Structure of paired immunoglobulin-like type 2 receptor (PILR ) 2013-10-31 2014-05-28 Lu, Q.,Lu, G.,Qi, J.,Wang, H.,Xuan, Y.,Wang, Q.,Li, Y.,Zhang, Y.,Zheng, C.,Fan, Z.,Yan, J.,Gao, G.F. PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid Proc.Natl.Acad.Sci.USA 2014 111 8221 8226 4NFD 24843130 Structure of PILR L108W mutant in complex with sialic acid 2013-10-31 2014-05-28 Lu, Q.,Lu, G.,Qi, J.,Wang, H.,Xuan, Y.,Wang, Q.,Li, Y.,Zhang, Y.,Zheng, C.,Fan, Z.,Yan, J.,Gao, G.F. PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid Proc.Natl.Acad.Sci.USA 2014 111 8221 8226 4OLK 24831957 The CHAP domain of LysGH15 2014-01-24 2014-05-28 Gu, J.,Feng, Y.,Feng, X.,Sun, C.,Lei, L.,Ding, W.,Niu, F.,Jiao, L.,Yang, M.,Li, Y.,Liu, X.,Song, J.,Cui, Z.,Han, D.,Du, C.,Yang, Y.,Ouyang, S.,Liu, Z.J.,Han, W. Structural and biochemical characterization reveals LysGH15 as an unprecedented ""EF-hand-like"" calcium-binding phage lysin. Plos Pathog. 2014 10 0 0 4OSH 24622844 Crystal structure of the TAL effector dHax3 with NI RVD at 2.2 angstrom resolution 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSI 24622844 Crystal structure of the TAL effector dHax3 with NI RVD at 2.8 angstrom resolution 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSJ 24622844 Crystal structure of TAL effector reveals the recognition between asparagine and adenine 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSK 24622844 Crystal structure of TAL effector reveals the recognition between asparagine and guanine 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSL 24622844 Crystal structure of TAL effector reveals the recognition between histidine and guanine 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSM 24622844 Crystal structure of the S505H mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSQ 24622844 Crystal structure of the S505R mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSR 24622844 Crystal structure of the S505K mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSS 24622844 Crystal structure of the S505Q mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OST 24622844 Crystal structure of the S505C mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSV 24622844 Crystal structure of the S505M mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSW 24622844 Crystal structure of the S505E mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OSZ 24622844 Crystal structure of the S505P mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OT0 24622844 Crystal structure of the S505T mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OT3 24622844 Crystal structure of the S505L mutant of TAL effector dHax3 2014-02-13 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4OTO 24622844 Crystal structure of the S505W mutant of TAL effector dHax3 2014-02-14 2014-05-28 Deng, D.,Yan, C.Y.,Wu, J.P.,Pan, X.J.,Yan, N. Revisiting the TALE repeat Protein Cell 2014 5 297 306 4IKG 23481402 Crystal structure of cell death-inducing DFFA-like effector c 2012-12-26 2014-06-04 Sun, Z.,Gong, J.,Wu, H.,Xu, W.,Wu, L.,Xu, D.,Gao, J.,Wu, J.W.,Yang, H.,Yang, M.,Li, P. Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun 2013 4 1594 1594 4L0C Crystal structure of the N-Fopmylmaleamic acid deformylase Nfo(S94A) from Pseudomonas putida S16 2013-05-31 2014-06-04 Chen, D.,Lu, Y.,Zhang, Z.,Wu, G.,Xu, P. Crystal structure of the N-Fopmylmaleamic acid deformylase Nfo from Pseudomonas putida S16 To be Published 0 0 0 0 4LMA 24275508 Crystal structure analysis of O-acetylserine sulfhydrylase CysK1 from Microcystis aeruginosa 7806 2013-07-10 2014-06-04 Lu, M.,Xu, B.Y.,Zhou, K.,Cheng, W.,Jiang, Y.L.,Chen, Y.,Zhou, C.Z. Structural and biochemical analyses of Microcystis aeruginosa O-acetylserine sulfhydrylases reveal a negative feedback regulation of cysteine biosynthesis. Biochim.Biophys.Acta 2014 1844 308 315 4LMB 24275508 Crystal structure analysis of O-acetylserine sulfhydrylase CysK2 complexed with cystine from Microcystis aeruginosa 7806 2013-07-10 2014-06-04 Lu, M.,Xu, B.Y.,Zhou, K.,Cheng, W.,Jiang, Y.L.,Chen, Y.,Zhou, C.Z. Structural and biochemical analyses of Microcystis aeruginosa O-acetylserine sulfhydrylases reveal a negative feedback regulation of cysteine biosynthesis. Biochim.Biophys.Acta 2014 1844 308 315 4OLS 24831957 The amidase-2 domain of LysGH15 2014-01-24 2014-06-04 Gu, J.,Feng, Y.,Feng, X.,Sun, C.,Lei, L.,Ding, W.,Niu, F.,Jiao, L.,Yang, M.,Li, Y.,Liu, X.,Song, J.,Cui, Z.,Han, D.,Du, C.,Yang, Y.,Ouyang, S.,Liu, Z.J.,Han, W. Structural and biochemical characterization reveals LysGH15 as an unprecedented ""EF-hand-like"" calcium-binding phage lysin. Plos Pathog. 2014 10 0 0 4Q05 24867954 Crystal structure of an esterase E25 2014-03-31 2014-06-04 Li, P.Y.,Ji, P.,Li, C.Y.,Zhang, Y.,Wang, G.L.,Zhang, X.Y.,Xie, B.B.,Qin, Q.L.,Chen, X.L.,Zhou, B.C.,Zhang, Y.Z. Structural basis for dimerization and catalysis of a novel esterase from the GTSAG motif subfamily of the bacterial hormone-sensitive lipase family J.Biol.Chem. 2014 289 19031 19041 4PZ9 24914210 The native structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c 2014-03-28 2014-06-11 Zheng, Q.,Jiang, D.,Zhang, W.,Zhang, Q.,Zhao, Q.,Jin, J.,Li, X.,Yang, H.,Bartlam, M.,Shaw, N.,Zhou, W.,Rao, Z. Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase J.Biol.Chem. 2014 289 21242 21251 4L8Z 24751441 Crystal structure of Human Hsp90 with RL1 2013-06-18 2014-06-18 Ren, J.,Li, J.,Wang, Y.,Chen, W.,Shen, A.,Liu, H.,Chen, D.,Cao, D.,Li, Y.,Zhang, N.,Xu, Y.,Geng, M.,He, J.,Xiong, B.,Shen, J. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization Bioorg.Med.Chem.Lett. 2014 24 2525 2529 4L90 Crystal structure of Human Hsp90 with RL3 2013-06-18 2014-06-18 Li, J.,Ren, J.,Yang, M.,Xiong, B.,He, J. Crystal structure of Human Hsp90 with RL3 to be published 0 0 0 0 4L91 24751441 Crystal structure of Human Hsp90 with X29 2013-06-18 2014-06-18 Ren, J.,Li, J.,Wang, Y.,Chen, W.,Shen, A.,Liu, H.,Chen, D.,Cao, D.,Li, Y.,Zhang, N.,Xu, Y.,Geng, M.,He, J.,Xiong, B.,Shen, J. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization Bioorg.Med.Chem.Lett. 2014 24 2525 2529 4L93 Crystal structure of Human Hsp90 with S36 2013-06-18 2014-06-18 Li, J.,Ren, J.,Yang, M.,Xiong, B.,He, J. Crystal structure of Human Hsp90 with S36 To be Published 0 0 0 0 4L94 24751441 Crystal structure of Human Hsp90 with S46 2013-06-18 2014-06-18 Ren, J.,Li, J.,Wang, Y.,Chen, W.,Shen, A.,Liu, H.,Chen, D.,Cao, D.,Li, Y.,Zhang, N.,Xu, Y.,Geng, M.,He, J.,Xiong, B.,Shen, J. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization Bioorg.Med.Chem.Lett. 2014 24 2525 2529 4M00 24901708 Crystal structure of the ligand binding region of staphylococcal adhesion SraP 2013-08-01 2014-06-18 Yang, Y.H.,Jiang, Y.L.,Zhang, J.,Wang, L.,Bai, X.H.,Zhang, S.J.,Ren, Y.M.,Li, N.,Zhang, Y.H.,Zhang, Z.,Gong, Q.,Mei, Y.,Xue, T.,Zhang, J.R.,Chen, Y.,Zhou, C.Z. Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells Plos Pathog. 2014 10 0 0 4M01 24901708 N terminal fragment(residues 245-575) of binding region of SraP 2013-08-01 2014-06-18 Yang, Y.H.,Jiang, Y.L.,Zhang, J.,Wang, L.,Bai, X.H.,Zhang, S.J.,Ren, Y.M.,Li, N.,Zhang, Y.H.,Zhang, Z.,Gong, Q.,Mei, Y.,Xue, T.,Zhang, J.R.,Chen, Y.,Zhou, C.Z. Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells Plos Pathog. 2014 10 0 0 4M02 24901708 Middle fragment(residues 494-663) of the binding region of SraP 2013-08-01 2014-06-18 Yang, Y.H.,Jiang, Y.L.,Zhang, J.,Wang, L.,Bai, X.H.,Zhang, S.J.,Ren, Y.M.,Li, N.,Zhang, Y.H.,Zhang, Z.,Gong, Q.,Mei, Y.,Xue, T.,Zhang, J.R.,Chen, Y.,Zhou, C.Z. Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells Plos Pathog. 2014 10 0 0 4M03 24901708 C-terminal fragment(residues 576-751) of binding region of SraP 2013-08-01 2014-06-18 Yang, Y.H.,Jiang, Y.L.,Zhang, J.,Wang, L.,Bai, X.H.,Zhang, S.J.,Ren, Y.M.,Li, N.,Zhang, Y.H.,Zhang, Z.,Gong, Q.,Mei, Y.,Xue, T.,Zhang, J.R.,Chen, Y.,Zhou, C.Z. Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells Plos Pathog. 2014 10 0 0 4O8C 24915075 Structure of the H170Y mutant of thermostable p-nitrophenylphosphatase from Bacillus Stearothermophilus 2013-12-27 2014-06-18 Shen, T.,Guo, Z.,Ji, C. Structure of a His170Tyr mutant of thermostable pNPPase from Geobacillus stearothermophilus. Acta Crystallogr.,Sect.F 2014 70 697 702 4PQG 24936067 Crystal structure of the pneumococcal O-GlcNAc transferase GtfA in complex with UDP and GlcNAc 2014-03-03 2014-06-18 Shi, W.W.,Jiang, Y.L.,Zhu, F.,Yang, Y.H.,Shao, Q.Y.,Yang, H.B.,Ren, Y.M.,Wu, H.,Chen, Y.,Zhou, C.Z. Structure of a Novel O-Linked N-Acetyl-d-glucosamine (O-GlcNAc) Transferase, GtfA, Reveals Insights into the Glycosylation of Pneumococcal Serine-rich Repeat Adhesins. J.Biol.Chem. 2014 289 20898 20907 4L22 Crystal structure of putative glycogen phosphorylase from Streptococcus mutans 2013-06-04 2014-06-25 Lihan, M.-Y.,Li, G.-L.,Li, L.-F.,Su, X.-D. Crystal structure of putative glycogen phosphorylase from Streptococcus mutans To be Published 0 0 0 0 4LA4 Crystal structure of native PnpB 2013-06-19 2014-06-25 Su, J.,Zhang, C.,Li, N.,Gu, L. Crystal structure of native PnpB To be Published 0 0 0 0 4LAF Crystal structure of PnpB complex with FMN 2013-06-19 2014-06-25 Su, J.,Zhang, C.,Li, N.,Gu, L. Crystal structure of PnpB complex with FMN To be Published 0 0 0 0 4ML0 24923448 Crystal structure of E.coli DinJ-YafQ complex 2013-09-06 2014-06-25 Liang, Y.,Gao, Z.,Wang, F.,Zhang, Y.,Dong, Y.,Liu, Q. Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ J.Biol.Chem. 2014 289 21191 21202 4OCH 24811920 Apo structure of Smr domain of MutS2 from Deinococcus radiodurans 2014-01-09 2014-06-25 Zhang, H.,Xu, Q.,Lu, M.,Xu, X.,Wang, Y.,Wang, L.,Zhao, Y.,Hua, Y. Structural and functional studies of MutS2 from Deinococcus radiodurans. Dna Repair 2014 21 111 119 4OD6 24811920 Structure of Smr domain of MutS2 from Deinococcus radiodurans, Mn2+ soaked 2014-01-10 2014-06-25 Zhang, H.,Xu, Q.,Lu, M.,Xu, X.,Wang, Y.,Wang, L.,Zhao, Y.,Hua, Y. Structural and functional studies of MutS2 from Deinococcus radiodurans. Dna Repair 2014 21 111 119 4OHB 24920828 Crystal structure of MilB E103A in complex with 5-hydroxymethylcytidine 5'-monophosphate (hmCMP) from Streptomyces rimofaciens 2014-01-17 2014-06-25 Zhao, G.,Wu, G.,Zhang, Y.,Liu, G.,Han, T.,Deng, Z.,He, X. Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry Nucleic Acids Res. 2014 42 8115 8124 4OHR 24920828 Crystal structure of MilB from Streptomyces rimofaciens 2014-01-17 2014-06-25 Zhao, G.,Wu, G.,Zhang, Y.,Liu, G.,Han, T.,Deng, Z.,He, X. Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry Nucleic Acids Res. 2014 42 8115 8124 4Q35 24990751 Structure of a membrane protein 2014-04-11 2014-06-25 Qiao, S.,Luo, Q.,Zhao, Y.,Zhang, X.C.,Huang, Y. Structural basis for lipopolysaccharide insertion in the bacterial outer membrane. Nature 2014 511 108 111 4MQV 24910198 Crystal complex of Rpa32c and Smarcal1 N-terminus 2013-09-16 2014-07-02 Xie, S.,Lu, Y.,Jakoncic, J.,Sun, H.,Xia, J.,Qian, C.M. Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins Febs J. 2014 281 3382 3396 4OIY 24613384 Crystal structure of Sec7p catalytic domain 2014-01-20 2014-07-02 Qiu, B.,Zhang, K.,Wang, S.L.,Sun, F. C-terminal motif within Sec7 domain regulates guanine nucleotide exchange activity via tuning protein conformation Biochem.Biophys.Res.Commun. 2014 446 380 386 4Q2G 24968740 CRYSTAL STRUCTURE OF AN INTRAMEMBRANE CDP-DAG SYNTHETASE CENTRAL FOR PHOSPHOLIPID BIOSYNTHESIS (S200C/S223C, inactive mutant) 2014-04-08 2014-07-02 Liu, X.,Yin, Y.,Wu, J.,Liu, Z. Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis Nat Commun 2014 5 4244 4244 4PSW 24835250 Crystal structure of histone acetyltransferase complex 2014-03-08 2014-07-09 Li, Y.,Zhang, L.,Liu, T.,Chai, C.,Fang, Q.,Wu, H.,Agudelo garcia, P.A.,Han, Z.,Zong, S.,Yu, Y.,Zhang, X.,Parthun, M.R.,Chai, J.,Xu, R.M.,Yang, M. Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex Genes Dev. 2014 28 1217 1227 4PSX 24835250 Crystal structure of histone acetyltransferase complex 2014-03-08 2014-07-09 Li, Y.,Zhang, L.,Liu, T.,Chai, C.,Fang, Q.,Wu, H.,Agudelo garcia, P.A.,Han, Z.,Zong, S.,Yu, Y.,Zhang, X.,Parthun, M.R.,Chai, J.,Xu, R.M.,Yang, M. Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex Genes Dev. 2014 28 1217 1227 4QE7 25024268 Open MthK pore structure soaked in 10 mM Ba2+/100 mM Na+ 2014-05-15 2014-07-09 Guo, R.,Zeng, W.,Cui, H.,Chen, L.,Ye, S. Ionic interactions of Ba2+ blockades in the MthK K+ channel J.Gen.Physiol. 2014 144 193 200 4QE9 25024268 Open MthK pore structure soaked in 10 mM Ba2+/100 mM K+ 2014-05-15 2014-07-09 Guo, R.,Zeng, W.,Cui, H.,Chen, L.,Ye, S. Ionic interactions of Ba2+ blockades in the MthK K+ channel J.Gen.Physiol. 2014 144 193 200 4QMF 24990943 Structure of the Krr1 and Faf1 complex from Saccharomyces cerevisiae 2014-06-16 2014-07-09 Zheng, S.,Lan, P.,Liu, X.,Ye, K. Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast J.Biol.Chem. 2014 289 22692 22703 4LPI 26458300 A sperm whale myoglobin double mutant L29H/F43Y Mb with a distal hydrogen-bonding network 2013-07-16 2014-07-16 Yan, D.J.,Yuan, H.,Li, W.,Xiang, Y.,He, B.,Nie, C.M.,Wen, G.B.,Lin, Y.W.,Tan, X. How a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: a direct comparitive study of L29H/F43Y myoglobin Dalton Trans 2015 44 18815 18822 4NQ0 24946827 Structural insights into yeast histone chaperone Hif1: a scaffold protein recruiting protein complexes to core histones 2013-11-23 2014-07-16 Liu, H.,Zhang, M.,He, W.,Zhu, Z.,Teng, M.,Gao, Y.,Niu, L. Structural insights into yeast histone chaperone Hif1: a scaffold protein recruiting protein complexes to core histones Biochem.J. 2014 462 465 473 4Q2W 25002590 Crystal Structure of pneumococcal peptidoglycan hydrolase LytB 2014-04-10 2014-07-16 Bai, X.H.,Chen, H.J.,Jiang, Y.L.,Wen, Z.,Huang, Y.,Cheng, W.,Li, Q.,Qi, L.,Zhang, J.R.,Chen, Y.,Zhou, C.Z. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. J.Biol.Chem. 2014 289 23403 23416 4LNR 25028510 The structure of HLA-B*35:01 in complex with the peptide (RPQVPLRPMTY) 2013-07-12 2014-07-23 Yanaka, S.,Ueno, T.,Shi, Y.,Qi, J.,Gao, G.F.,Tsumoto, K.,Sugase, K. Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex. J.Biol.Chem. 2014 289 24680 24690 4LQL Crystal structure of L-arabinose isomerase from Lactobacillus fermentum CGMCC2921 2013-07-19 2014-07-23 Xu, Z. Crystal structure of L-arabinose isomerase from Lactobacillus fermentum CGMCC2921 to be published 0 0 0 0 4LS0 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033 2013-07-21 2014-07-23 Zhu, L.,Li, H.,Ren, X.,Zhu, J. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DHO1B0033 To be Published 0 0 0 0 4LS1 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 2013-07-21 2014-07-23 Zhu, L.,Li, H.,Ren, X.,Zhu, J. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 To be Published 0 0 0 0 4LS2 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 2013-07-21 2014-07-23 Zhu, L.,Li, H.,Ren, X.,Zhu, J. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 To be Published 0 0 0 0 4MFI 24299297 Crystal structure of Mycobacterium tuberculosis UgpB 2013-08-28 2014-07-23 Jiang, D.,Zhang, Q.,Zheng, Q.,Zhou, H.,Jin, J.,Zhou, W.,Bartlam, M.,Rao, Z. Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine Febs J. 2014 281 331 341 4MH1 24557074 Crystal structure and functional studies of quinoprotein L-sorbose dehydrogenase from Ketogulonicigenium vulgare Y25 2013-08-29 2014-07-23 Han, X.,Xiong, X.,Jiang, D.,Chen, S.,Huang, E.,Zhang, W.,Liu, X. Crystal structure of L-sorbose dehydrogenase, a pyrroloquinoline quinone-dependent enzyme with homodimeric assembly, from Ketogulonicigenium vulgare Biotechnol.Lett. 2014 36 1001 1008 4N3X 24957337 Crystal structure of Rabex-5 CC domain 2013-10-08 2014-07-23 Zhang, Z.,Zhang, T.,Wang, S.,Gong, Z.,Tang, C.,Chen, J.,Ding, J. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 Elife 2014 3 0 0 4N3Y 24957337 Crystal structure of Rabex-5CC and Rabaptin-5C21 complex 2013-10-08 2014-07-23 Zhang, Z.,Zhang, T.,Wang, S.,Gong, Z.,Tang, C.,Chen, J.,Ding, J. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 Elife 2014 3 0 0 4N3Z 24957337 Crystal structure of Rabex-5delta and Rabaptin-5C21 complex 2013-10-08 2014-07-23 Zhang, Z.,Zhang, T.,Wang, S.,Gong, Z.,Tang, C.,Chen, J.,Ding, J. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 Elife 2014 3 0 0 4O2C 24829406 An Nt-acetylated peptide complexed with HLA-B*3901 2013-12-17 2014-07-23 Sun, M.,Liu, J.,Qi, J.,Tefsen, B.,Shi, Y.,Yan, J.,Gao, G.F. N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation J.Immunol. 2014 192 5509 5519 4O2E 24829406 A peptide complexed with HLA-B*3901 2013-12-17 2014-07-23 Sun, M.,Liu, J.,Qi, J.,Tefsen, B.,Shi, Y.,Yan, J.,Gao, G.F. N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation J.Immunol. 2014 192 5509 5519 4O2F 24829406 A peptide complexed with HLA-B*3901 2013-12-17 2014-07-23 Sun, M.,Liu, J.,Qi, J.,Tefsen, B.,Shi, Y.,Yan, J.,Gao, G.F. N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation J.Immunol. 2014 192 5509 5519 4Q9U 24957337 Crystal structure of the Rab5, Rabex-5delta and Rabaptin-5C21 complex 2014-05-01 2014-07-23 Zhang, Z.,Zhang, T.,Wang, S.,Gong, Z.,Tang, C.,Chen, J.,Ding, J. Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 Elife 2014 3 0 0 4LA1 Crystal structure of SjTGR (thioredoxin glutathione reductase from Schistosoma japonicumi)complex with FAD 2013-06-18 2014-07-30 Peng, Y.,Wu, Q.,Huang, F.,Chen, J.,Li, X.,Zhou, X.,Fan, X. Crystal structure of SjTGR complex with FAD To be Published 0 0 0 0 4LWE 25313505 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2 2013-07-27 2014-07-30 Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem. 2014 87 765 781 4LWF 25313505 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3 2013-07-27 2014-07-30 Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem. 2014 87 765 781 4LWG 25313505 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4 2013-07-27 2014-07-30 Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem. 2014 87 765 781 4LWH 25313505 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 2013-07-27 2014-07-30 Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem. 2014 87 765 781 4LWI 25313505 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6 2013-07-27 2014-07-30 Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem. 2014 87 765 781 4QN3 24899180 Crystal structure of Neuraminidase N7 2014-06-17 2014-07-30 Sun, X.,Li, Q.,Wu, Y.,Wang, M.,Liu, Y.,Qi, J.,Vavricka, C.J.,Gao, G.F. Structure of influenza virus N7: the last piece of the neuraminidase ""jigsaw"" puzzle. J.Virol. 2014 88 9197 9207 4QN4 24899180 Crystal structure of Neuraminidase N6 2014-06-17 2014-07-30 Sun, X.,Li, Q.,Wu, Y.,Wang, M.,Liu, Y.,Qi, J.,Vavricka, C.J.,Gao, G.F. Structure of influenza virus N7: the last piece of the neuraminidase ""jigsaw"" puzzle. J.Virol. 2014 88 9197 9207 4QN5 24899180 Neuraminidase N5 binds LSTa at the second SIA binding site 2014-06-17 2014-07-30 Sun, X.,Li, Q.,Wu, Y.,Wang, M.,Liu, Y.,Qi, J.,Vavricka, C.J.,Gao, G.F. Structure of influenza virus N7: the last piece of the neuraminidase ""jigsaw"" puzzle. J.Virol. 2014 88 9197 9207 4QN6 24899180 Crystal structure of Neuraminidase N6 complexed with Laninamivir 2014-06-17 2014-07-30 Sun, X.,Li, Q.,Wu, Y.,Wang, M.,Liu, Y.,Qi, J.,Vavricka, C.J.,Gao, G.F. Structure of influenza virus N7: the last piece of the neuraminidase ""jigsaw"" puzzle. J.Virol. 2014 88 9197 9207 4QN7 24899180 Crystal structure of neuramnidase N7 complexed with Oseltamivir 2014-06-17 2014-07-30 Sun, X.,Li, Q.,Wu, Y.,Wang, M.,Liu, Y.,Qi, J.,Vavricka, C.J.,Gao, G.F. Structure of influenza virus N7: the last piece of the neuraminidase ""jigsaw"" puzzle. J.Virol. 2014 88 9197 9207 3WOH 24901639 Structure of Ketoreductase SiaM from Streptomyces sp. A7248 2013-12-29 2014-08-06 Wang, H.,Zhang, H.,Zou, Y.,Mi, Y.,Lin, S.,Xie, Z.,Yan, Y.,Zhang, H. Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces Plos One 2014 9 0 0 4OBW 25084328 crystal structure of yeast Coq5 in the SAM bound form 2014-01-07 2014-08-06 Dai, Y.N.,Zhou, K.,Cao, D.D.,Jiang, Y.L.,Meng, F.,Chi, C.B.,Ren, Y.M.,Chen, Y.,Zhou, C.Z. Crystal structures and catalytic mechanism of the C-methyltransferase Coq5 provide insights into a key step of the yeast coenzyme Q synthesis pathway. Acta Crystallogr.,Sect.D 2014 70 2085 2092 4OBX 25084328 Crystal structure of yeast Coq5 in the apo form 2014-01-07 2014-08-06 Dai, Y.N.,Zhou, K.,Cao, D.D.,Jiang, Y.L.,Meng, F.,Chi, C.B.,Ren, Y.M.,Chen, Y.,Zhou, C.Z. Crystal structures and catalytic mechanism of the C-methyltransferase Coq5 provide insights into a key step of the yeast coenzyme Q synthesis pathway. Acta Crystallogr.,Sect.D 2014 70 2085 2092 4QDJ 25077963 Crystal structure of magnesium protoporphyrin IX methyltransferase (ChlM) from Synechocystis PCC 6803 with bound SAM 2014-05-14 2014-08-06 Chen, X.,Wang, X.,Feng, J.,Chen, Y.,Fang, Y.,Zhao, S.,Zhao, A.,Zhang, M.,Liu, L. Structural insights into the catalytic mechanism of Synechocystis magnesium protoporphyrin IX O-methyltransferase (ChlM). J.Biol.Chem. 2014 289 25690 25698 4QDJ 25077963 Crystal structure of magnesium protoporphyrin IX methyltransferase (ChlM) from Synechocystis PCC 6803 with bound SAM 2014-05-14 2014-08-06 Chen, X.,Wang, X.,Feng, J.,Chen, Y.,Fang, Y.,Zhao, S.,Zhao, A.,Zhang, M.,Liu, L. Structural insights into the catalytic mechanism of Synechocystis magnesium protoporphyrin IX O-methyltransferase (ChlM). J.Biol.Chem. 2014 289 25690 25698 4QDK 25077963 Crystal structure of magnesium protoporphyrin IX methyltransferase (ChlM) from Synechocystis PCC 6803 with bound SAH 2014-05-14 2014-08-06 Chen, X.,Wang, X.,Feng, J.,Chen, Y.,Fang, Y.,Zhao, S.,Zhao, A.,Zhang, M.,Liu, L. Structural insights into the catalytic mechanism of Synechocystis magnesium protoporphyrin IX O-methyltransferase (ChlM). J.Biol.Chem. 2014 289 25690 25698 4TXT Crystal Structure of a GH48 cellobiohydrolase from Caldicellulosiruptor bescii 2014-07-07 2014-08-06 An, J.,Feng, Y.,Bai, A. Crystallization and preliminary X-ray analysis of a processive cellobiohydrolase CbCBH48A from Caldicellulosiruptor bescii To Be Published 0 0 0 0 4OU6 25053836 Crystal structure of DnaT84-153-dT10 ssDNA complex form 1 2014-02-15 2014-08-13 Liu, Z.,Chen, P.,Wang, X.,Cai, G.,Niu, L.,Teng, M.,Li, X. Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res. 2014 42 9470 9483 4OU7 25053836 Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode 2014-02-15 2014-08-13 Liu, Z.,Chen, P.,Wang, X.,Cai, G.,Niu, L.,Teng, M.,Li, X. Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res. 2014 42 9470 9483 4Q65 25066136 Structure of the E. coli Peptide Transporter YbgH 2014-04-21 2014-08-13 Zhao, Y.,Mao, G.,Liu, M.,Zhang, L.,Wang, X.,Zhang, X.C. Crystal structure of the E. coli peptide transporter YbgH. Structure 2014 22 1152 1160 4QTJ 25091450 Complex of WOPR domain of Wor1 in Candida albicans with the 13bp dsDNA 2014-07-08 2014-08-13 Zhang, S.,Zhang, T.,Yan, M.,Ding, J.,Chen, J. Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans. Cell Res. 2014 24 1108 1120 4QTK 25091450 Complex of WOPR domain of Wor1 in Candida albicans with the 17bp dsDNA 2014-07-08 2014-08-13 Zhang, S.,Zhang, T.,Yan, M.,Ding, J.,Chen, J. Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans. Cell Res. 2014 24 1108 1120 4OV9 25128527 Structure of isopropylmalate synthase binding with alpha-isopropylmalate 2014-02-20 2014-08-20 Zhang, Z.,Wu, J.,Lin, W.,Wang, J.,Yan, H.,Zhao, W.,Ma, J.,Ding, J.,Zhang, P.,Zhao, G.P. Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J.Biol.Chem. 2014 289 27966 27978 4QKD 25122757 Crystal structure of human ALKBH7 in complex with alpha-ketoglutarate and Mn(II) 2014-06-06 2014-08-20 Wang, G.,He, Q.,Feng, C.,Liu, Y.,Deng, Z.,Qi, X.,Wu, W.,Mei, P.,Chen, Z. The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism J.Biol.Chem. 2014 289 27924 27936 4LU9 24531464 Crystal structure of E.coli SbcD at 2.5 angstrom resolution 2013-07-25 2014-08-27 Liu, S.,Tian, L.F.,Liu, Y.P.,An, X.M.,Tang, Q.,Yan, X.X.,Liang, D.C. Structural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repair. Acta Crystallogr.,Sect.D 2014 70 299 309 4MJS 24369353 crystal structure of a PB1 complex 2013-09-04 2014-08-27 Ren, J.,Wang, J.,Wang, Z.X.,Wu, J.W. Structural and biochemical insights into the homotypic PB1-PB1 complex between PKC zeta and p62 Sci China Life Sci 2014 57 69 80 4N40 25068414 Crystal structure of human Epithelial cell-transforming sequence 2 protein 2013-10-08 2014-08-27 Zou, Y.,Shao, Z.H.,Peng, J.,Li, F.D.,Gong, D.,Wang, C.,Zuo, X.,Zhang, Z.,Wu, J.,Shi, Y.,Gong, Q. Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 Febs Lett. 2014 588 2911 2920 4N40 25068414 Crystal structure of human Epithelial cell-transforming sequence 2 protein 2013-10-08 2014-08-27 Zou, Y.,Shao, Z.H.,Peng, J.,Li, F.D.,Gong, D.,Wang, C.,Zuo, X.,Zhang, Z.,Wu, J.,Shi, Y.,Gong, Q. Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 Febs Lett. 2014 588 2911 2920 4QLA 25143157 Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori 2014-06-11 2014-09-03 Zhou, K.,Jia, N.,Hu, C.,Jiang, Y.L.,Yang, J.P.,Chen, Y.,Li, S.,Li, W.F.,Zhou, C.Z. Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 2014 82 3224 3229 4O8S 25101777 Crystal structure of JHP933 from Helicobacter pylori 2013-12-30 2014-09-10 Zhao, Y.,Ye, X.,Su, Y.,Sun, L.,She, F.,Wu, Y. Crystal Structure Confirmation of JHP933 as a Nucleotidyltransferase Superfamily Protein from Helicobacter pylori Strain J99 Plos One 2014 9 0 0 4OKY 25195760 Crystal structure of PvuRts1I, a 5-hydroxymethylcytosine DNA restriction endonuclease 2014-01-23 2014-09-10 Shao, C.,Wang, C.,Zang, J. Structural basis for the substrate selectivity of PvuRts1I, a 5-hydroxymethylcytosine DNA restriction endonuclease Acta Crystallogr.,Sect.D 2014 70 2477 2486 4QXA 25220469 Crystal structure of the Rab9A-RUTBC2 RBD complex 2014-07-19 2014-09-10 Zhang, Z.,Wang, S.,Shen, T.,Chen, J.,Ding, J. Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2. Structure 2014 22 1408 1420 4MM0 Crystal Structure Analysis of the Putative Thioether Synthase SgvP Involved in the Tailoring Step of Griseoviridin 2013-09-07 2014-09-17 Zhang, H.,Huang, L.,Yi, M.,Cai, T.,Zhang, H. Structural Analysis of SgvP: a Putative Thioether Synthase Involved in the Tailoring Step of Griseoviridin To be Published 0 0 0 0 4Q1Q 25211077 Crystal structure of TibC-catalyzed hyper-glycosylated TibA55-350 fragment 2014-04-04 2014-09-17 Lu, Q.,Yao, Q.,Xu, Y.,Li, L.,Li, S.,Liu, Y.,Gao, W.,Niu, M.,Sharon, M.,Ben-Nissan, G.,Zamyatina, A.,Liu, X.,Chen, S.,Shao, F. An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis Cell Host Microbe 2014 16 351 363 4Q8K 25210041 Crystal structure of polysaccharide lyase family 18 aly-SJ02 P-CATD 2014-04-28 2014-09-17 Dong, S.,Wei, T.D.,Chen, X.L.,Li, C.Y.,Wang, P.,Xie, B.B.,Qin, Q.L.,Zhang, X.Y.,Pang, X.H.,Zhou, B.C.,Zhang, Y.Z. Molecular insight into the role of the N-terminal extension in the maturation, substrate recognition, and catalysis of a bacterial alginate lyase from polysaccharide lyase family 18. J.Biol.Chem. 2014 289 29558 29569 4Q8L 25210041 Crystal structure of polysacchride lyase family 18 aly-SJ02 r-CATD 2014-04-28 2014-09-17 Dong, S.,Wei, T.D.,Chen, X.L.,Li, C.Y.,Wang, P.,Xie, B.B.,Qin, Q.L.,Zhang, X.Y.,Pang, X.H.,Zhou, B.C.,Zhang, Y.Z. Molecular insight into the role of the N-terminal extension in the maturation, substrate recognition, and catalysis of a bacterial alginate lyase from polysaccharide lyase family 18. J.Biol.Chem. 2014 289 29558 29569 4R12 25197054 Crystal structure of the gamma-secretase component Nicastrin 2014-08-03 2014-09-17 Xie, T.,Yan, C.,Zhou, R.,Zhao, Y.,Sun, L.,Yang, G.,Lu, P.,Ma, D.,Shi, Y. Crystal structure of the gamma-secretase component nicastrin. Proc.Natl.Acad.Sci.USA 2014 111 13349 13354 4U03 25201413 Structure of the vibrio cholerae di-nucleotide cyclase (DncV) in complex with GTP and 5MTHFGLU2 2014-07-11 2014-09-17 Zhu, D.,Wang, L.,Shang, G.,Liu, X.,Zhu, J.,Lu, D.,Wang, L.,Kan, B.,Zhang, J.R.,Xiang, Y. Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Mol.Cell 2014 55 931 937 4U0L 25201413 Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D131A-D133A 2014-07-12 2014-09-17 Zhu, D.,Wang, L.,Shang, G.,Liu, X.,Zhu, J.,Lu, D.,Wang, L.,Kan, B.,Zhang, J.R.,Xiang, Y. Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Mol.Cell 2014 55 931 937 4U0M 25201413 Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D193N in complex with ATP, GTP and 5MTHFGLU2 2014-07-12 2014-09-17 Zhu, D.,Wang, L.,Shang, G.,Liu, X.,Zhu, J.,Lu, D.,Wang, L.,Kan, B.,Zhang, J.R.,Xiang, Y. Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Mol.Cell 2014 55 931 937 4U0N 25201413 Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) deletion mutant D-loop 2014-07-12 2014-09-17 Zhu, D.,Wang, L.,Shang, G.,Liu, X.,Zhu, J.,Lu, D.,Wang, L.,Kan, B.,Zhang, J.R.,Xiang, Y. Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Mol.Cell 2014 55 931 937 4NX2 25197956 Crystal structure of DCYRS complexed with DCY 2013-12-08 2014-09-24 Liu, X.,Jiang, L.,Li, J.,Wang, L.,Yu, Y.,Zhou, Q.,Lv, X.,Gong, W.,Lu, Y.,Wang, J. Significant expansion of fluorescent protein sensing ability through the genetic incorporation of superior photo-induced electron-transfer quenchers. J.Am.Chem.Soc. 2014 136 13094 13097 4NXE 25197956 Crystal structure of iLOV-I486(2LT) at pH 6.5 2013-12-09 2014-09-24 Liu, X.,Jiang, L.,Li, J.,Wang, L.,Yu, Y.,Zhou, Q.,Lv, X.,Gong, W.,Lu, Y.,Wang, J. Significant expansion of fluorescent protein sensing ability through the genetic incorporation of superior photo-induced electron-transfer quenchers. J.Am.Chem.Soc. 2014 136 13094 13097 4NXF 25197956 Crystal structure of iLOV-I486(2LT) at pH 8.0 2013-12-09 2014-09-24 Liu, X.,Jiang, L.,Li, J.,Wang, L.,Yu, Y.,Zhou, Q.,Lv, X.,Gong, W.,Lu, Y.,Wang, J. Significant expansion of fluorescent protein sensing ability through the genetic incorporation of superior photo-induced electron-transfer quenchers. J.Am.Chem.Soc. 2014 136 13094 13097 4NXG 25197956 Crystal structure of iLOV-I486z(2LT) at pH 9.0 2013-12-09 2014-09-24 Liu, X.,Jiang, L.,Li, J.,Wang, L.,Yu, Y.,Zhou, Q.,Lv, X.,Gong, W.,Lu, Y.,Wang, J. Significant expansion of fluorescent protein sensing ability through the genetic incorporation of superior photo-induced electron-transfer quenchers. J.Am.Chem.Soc. 2014 136 13094 13097 4OE1 25231995 Crystal structure of the pentatricopeptide repeat protein PPR10 (C256S/C430S/C449S) in complex with an 18-nt PSAJ rna element 2014-01-11 2014-09-24 Li, Q.,Yan, C.,Xu, H.,Wang, Z.,Long, J.,Li, W.,Wu, J.,Yin, P.,Yan, N. Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10). J.Biol.Chem. 2014 289 31503 31512 4ON3 25212774 Crystal structure of human sorting nexin 10 (SNX10) 2014-01-28 2014-09-24 Xu, T.,Xu, J.,Ye, Y.,Wang, Q.,Shu, X.,Pei, D.,Liu, J. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 2014 82 3483 3489 4PZG 25212774 Crystal structure of human sorting nexin 10 (SNX10) 2014-03-30 2014-09-24 Xu, T.,Xu, J.,Ye, Y.,Wang, Q.,Shu, X.,Pei, D.,Liu, J. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 2014 82 3483 3489 4MY5 30713166 Crystal structure of the aromatic amino acid aminotransferase from Streptococcus mutants 2013-09-27 2014-10-01 Cong, X.,Li, X.,Li, S. Crystal structure of the aromatic-amino-acid aminotransferase from Streptococcus mutans. Acta Crystallogr.,Sect.F 2019 75 141 146 4MYV 25231300 Free HSV-2 gD structure 2013-09-28 2014-10-01 Lu, G.,Zhang, N.,Qi, J.,Li, Y.,Chen, Z.,Zheng, C.,Gao, G.F.,Yan, J. Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. J.Virol. 2014 88 13678 13688 4MYW 25231300 Structure of HSV-2 gD bound to nectin-1 2013-09-28 2014-10-01 Lu, G.,Zhang, N.,Qi, J.,Li, Y.,Chen, Z.,Zheng, C.,Gao, G.F.,Yan, J. Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. J.Virol. 2014 88 13678 13688 4QXF crystal structure of human LGR4 and Rspo1 2014-07-20 2014-10-08 Xu, J.G.,Huang, C.,Zhou, Y.,Zhu, Y. crystal structure of human LGR4 and Rspo1 TO BE PUBLISHED 0 0 0 0 4MXC 24944742 Crystal structure of CMET in complex with novel inhibitor 2013-09-26 2014-10-15 Zhan, Z.S.,Ai, J.,Liu, Q.F.,Ji, Y.C.,Chen, T.T.,Xu, Y.C.,Geng, M.Y.,Duan, W.H. Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity ACS MED.CHEM.LETT. 2014 5 673 678 4N77 Crystal structure of Cas protein 2013-10-15 2014-10-15 Tian, W.,Sheng, G.,Zhao, H.,Wang, J.,Wang, Y. Crystal strucute studies of CasD To be Published 0 0 0 0 4R6U 25261253 IL-18 receptor complex 2014-08-26 2014-10-15 Wei, H.,Wang, D.,Qian, Y.,Liu, X.,Fan, S.,Yin, H.S.,Wang, X. Structural basis for the specific recognition of IL-18 by its alpha receptor. Febs Lett. 2014 588 3838 3843 4PVC 24879127 Crystal structure of yeast methylglyoxal/ isovaleraldehyde reductase Gre2 2014-03-17 2014-10-22 Guo, P.C.,Bao, Z.Z.,Ma, X.X.,Xia, Q.,Li, W.F. Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2 Biochim.Biophys.Acta 2014 1844 1486 1492 4PVD 24879127 Crystal structure of yeast methylglyoxal/isovaleraldehyde reductase Gre2 complexed with NADPH 2014-03-17 2014-10-22 Guo, P.C.,Bao, Z.Z.,Ma, X.X.,Xia, Q.,Li, W.F. Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2 Biochim.Biophys.Acta 2014 1844 1486 1492 4Q9V 25242044 Crystal structure of TIPE3 2014-05-02 2014-10-22 Fayngerts, S.A.,Wu, J.,Oxley, C.L.,Liu, X.,Vourekas, A.,Cathopoulis, T.,Wang, Z.,Cui, J.,Liu, S.,Sun, H.,Lemmon, M.A.,Zhang, L.,Shi, Y.,Chen, Y.H. TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer. Cancer Cell 2014 26 465 478 4Q9V 25242044 Crystal structure of TIPE3 2014-05-02 2014-10-22 Fayngerts, S.A.,Wu, J.,Oxley, C.L.,Liu, X.,Vourekas, A.,Cathopoulis, T.,Wang, Z.,Cui, J.,Liu, S.,Sun, H.,Lemmon, M.A.,Zhang, L.,Shi, Y.,Chen, Y.H. TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer. Cancer Cell 2014 26 465 478 4QXE Crystal structure of LGR4 fused with hagfish VLR 2014-07-20 2014-10-22 Xu, J.G.,Huang, C.,Zhou, Y.,Zhu, Y. Crystal structure of LGR4 fused with hagfish VLR TO BE PUBLISHED 0 0 0 0 4NZZ 25331869 Crystal structure of epoxide hydrolase from bacillus megaterium 2013-12-13 2014-10-29 Kong, X.D.,Yuan, S.,Li, L.,Chen, S.,Xu, J.H.,Zhou, J. Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc.Natl.Acad.Sci.USA 2014 111 15717 15722 4O33 25383758 Crystal Structure of human PGK1 3PG and terazosin(TZN) ternary complex 2013-12-18 2014-10-29 Chen, X.,Zhao, C.,Li, X.,Wang, T.,Li, Y.,Cao, C.,Ding, Y.,Dong, M.,Finci, L.,Wang, J.H.,Li, X.,Liu, L. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat.Chem.Biol. 2015 11 19 25 4O6X 25307106 Crystal structure of human Ankyrin G death domain 2013-12-24 2014-10-29 Liu, Y.,Zhang, Y.,Wang, J.H. Crystal structure of human Ankyrin G death domain. Proteins 2014 82 3476 3482 4OH4 25331450 Crystal structure of BRI1 in complex with BKI1 2014-01-17 2014-10-29 Wang, J.,Jiang, J.,Wang, J.,Chen, L.,Fan, S.L.,Wu, J.W.,Wang, X.,Wang, Z.X. Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1. Cell Res. 2014 24 1328 1341 4OUL 25331957 Crystal structure of human Caprin-2 C1q domain 2014-02-17 2014-10-29 Miao, H.,Jia, Y.,Xie, S.,Wang, X.,Zhao, J.,Chu, Y.,Zhou, Z.,Shi, Z.,Song, X.,Li, L. Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling J.Biol.Chem. 2014 289 34104 34113 4OUM 25331957 Crystal structure of human Caprin-2 C1q domain 2014-02-18 2014-10-29 Miao, H.,Jia, Y.,Xie, S.,Wang, X.,Zhao, J.,Chu, Y.,Zhou, Z.,Shi, Z.,Song, X.,Li, L. Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling J.Biol.Chem. 2014 289 34104 34113 4OUS 25331957 Crystal structure of zebrafish Caprin-2 C1q domain 2014-02-18 2014-10-29 Miao, H.,Jia, Y.,Xie, S.,Wang, X.,Zhao, J.,Chu, Y.,Zhou, Z.,Shi, Z.,Song, X.,Li, L. Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling J.Biol.Chem. 2014 289 34104 34113 4Q5J 25331450 Crystal structure of SeMet derivative BRI1 in complex with BKI1 2014-04-17 2014-10-29 Wang, J.,Jiang, J.,Wang, J.,Chen, L.,Fan, S.L.,Wu, J.W.,Wang, X.,Wang, Z.X. Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1. Cell Res. 2014 24 1328 1341 4QZV 25211075 Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry 2014-07-29 2014-10-29 Wang, Q.H.,Qi, J.X.,Yuan, Y.,Xuan, Y.,Han, P.,Wan, Y.,Ji, W.,Li, Y.,Wu, Y.,Wang, J.,Iwamoto, A.,Woo, P.C.,Yuen, K.Y.,Yan, J.,Lu, G.W.,Gao, G.F. Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26. Cell Host Microbe 2014 16 328 337 4RAP 25310236 Crystal structure of bacterial iron-containing dodecameric glycosyltransferase TibC from enterotoxigenic E.coli H10407 2014-09-10 2014-10-29 Yao, Q.,Lu, Q.,Wan, X.,Song, F.,Xu, Y.,Hu, M.,Zamyatina, A.,Liu, X.,Huang, N.,Zhu, P.,Shao, F. A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family. Elife 2014 3 0 0 3WMB 25155420 Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q1 2013-11-16 2014-11-05 Liu, T.,Guo, P.,Zhou, Y.,Wang, J.,Chen, L.,Yang, H.,Qian, X.,Yang, Q. A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs Sci Rep 2014 4 6188 6188 3WMC 25155420 Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q2 2013-11-16 2014-11-05 Liu, T.,Guo, P.,Zhou, Y.,Wang, J.,Chen, L.,Yang, H.,Qian, X.,Yang, Q. A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs Sci Rep 2014 4 6188 6188 4R3M 25490978 Crystal structure of Human Hsp90 with JR9 2014-08-16 2014-11-05 Ren, J.,Yang, M.,Liu, H.,Cao, D.,Chen, D.,Li, J.,Tang, L.,He, J.,Chen, Y.L.,Geng, M.,Xiong, B.,Shen, J. Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity. Org.Biomol.Chem. 2015 13 1531 1535 4RB4 25310236 Crystal structure of dodecameric iron-containing heptosyltransferase TibC in complex with ADP-D-beta-D-heptose at 3.9 angstrom resolution 2014-09-12 2014-11-05 Yao, Q.,Lu, Q.,Wan, X.,Song, F.,Xu, Y.,Hu, M.,Zamyatina, A.,Liu, X.,Huang, N.,Zhu, P.,Shao, F. A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family Elife 2014 3 0 0 4TMP 25417107 Crystal structure of AF9 YEATS bound to H3K9ac peptide 2014-06-02 2014-11-05 Li, Y.,Wen, H.,Xi, Y.,Tanaka, K.,Wang, H.,Peng, D.,Ren, Y.,Jin, Q.,Dent, S.Y.,Li, W.,Li, H.,Shi, X. AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation. Cell 2014 159 558 571 4NT9 Crystal structure of an L,D-carboxypeptidase DacB from Streptococcus pneumonia 2013-12-02 2014-11-12 Yang, Y.H.,Zhang, J.,Jiang, Y.L.,Zhou, C.Z.,Chen, Y. Crystal structure of an L,D-carboxypeptidase DacB from Streptococcus pneumonia To be Published 0 0 0 0 4QSG 25372690 Crystal structure of gas vesicle protein GvpF from Microcystis aeruginosa 2014-07-03 2014-11-12 Xu, B.Y.,Dai, Y.N.,Zhou, K.,Liu, Y.T.,Sun, Q.,Ren, Y.M.,Chen, Y.,Zhou, C.Z. Structure of the gas vesicle protein GvpF from the cyanobacterium Microcystis aeruginosa. Acta Crystallogr.,Sect.D 2014 70 3013 3022 4U7P 25383530 Crystal structure of DNMT3A-DNMT3L complex 2014-07-31 2014-11-12 Guo, X.,Wang, L.,Li, J.,Ding, Z.,Xiao, J.,Yin, X.,He, S.,Shi, P.,Dong, L.,Li, G.,Tian, C.,Wang, J.,Cong, Y.,Xu, Y. Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature 2015 517 640 644 4U7T 25383530 Crystal structure of DNMT3A-DNMT3L in complex with histone H3 2014-07-31 2014-11-12 Guo, X.,Wang, L.,Li, J.,Ding, Z.,Xiao, J.,Yin, X.,He, S.,Shi, P.,Dong, L.,Li, G.,Tian, C.,Wang, J.,Cong, Y.,Xu, Y. Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature 2015 517 640 644 3WMI Crystal structure of EIAV wild type gp45 2013-11-19 2014-11-19 Liu, X.,Du, J.,Qiao, W. A mutation associated with EIAV vaccine strain within heptad repeat of EIAV gp45 provides insight into vaccine development for HIV To be Published 0 0 0 0 3WMJ Crystal structure of EIAV vaccine gp45 2013-11-19 2014-11-19 Liu, X.,Du, J.,Qiao, W. A mutation associated with EIAV vaccine strain within heptad repeat of EIAV gp45 provides insight into vaccine development for HIV To be Published 0 0 0 0 4NND Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites 2013-11-17 2014-11-19 Wang, H.,Yang, F.,Yang, D.,Du, Y. Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites To be Published 0 0 0 0 4NNS Crystal structure of FABP4 in complex with novel inhibitor 2013-11-19 2014-11-19 Liu, Q.F.,Chen, T.T.,Xu, Y.C. The complex structure of FABP4 with novel inhibitors To be Published 0 0 0 0 4NNT Crystal structure of FABP4 in complex with novel inhibitor 2013-11-19 2014-11-19 Liu, Q.F.,Chen, T.T.,Xu, Y.C. The complex structure of FABP4 with novel inhibitors To be Published 0 0 0 0 4NRR 25372687 Crystal Structure of Glycoside Hydrolase Family 5 Mannosidase (E202A mutant) from Rhizomucor miehei in complex with mannosyl-fructose 2013-11-27 2014-11-19 Zhou, P.,Liu, Y.,Yan, Q.,Chen, Z.,Qin, Z.,Jiang, Z. Structural insights into the substrate specificity and transglycosylation activity of a fungal glycoside hydrolase family 5 beta-mannosidase. Acta Crystallogr.,Sect.D 2014 70 2970 2982 4QBA 25368190 Crystal structure of the effector-binding domain of S. aureus CcpE 2014-05-06 2014-11-19 Ding, Y.,Liu, X.,Chen, F.,Di, H.,Xu, B.,Zhou, L.,Deng, X.,Wu, M.,Yang, C.G.,Lan, L. Metabolic sensor governing bacterial virulence in Staphylococcus aureus. Proc.Natl.Acad.Sci.USA 2014 111 0 0 4QII 25372686 Crystal Structure of type II MenB from Mycobacteria tuberculosis 2014-05-31 2014-11-19 Song, H.,Sung, H.P.,Tse, Y.S.,Jiang, M.,Guo, Z.H. Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues Acta Crystallogr.,Sect.D 2014 70 2959 2969 4QIJ 25372686 Crystal structure of MenB from Mycobacteria tuberculosis in complex with 1-HNA-CoA 2014-05-31 2014-11-19 Song, H.,Sung, H.P.,Tse, Y.S.,Jiang, M.,Guo, Z.H. Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues Acta Crystallogr.,Sect.D 2014 70 2959 2969 4RE1 25384421 Crystal structure of human TEAD1 and disulfide-engineered YAP 2014-09-21 2014-11-19 Zhou, Z.,Hu, T.,Xu, Z.,Lin, Z.,Zhang, Z.,Feng, T.,Zhu, L.,Rong, Y.,Shen, H.,Luk, J.M.,Zhang, X.,Qin, N. Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides. Faseb J. 2015 29 724 732 4RL0 25268575 Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins 2014-10-14 2014-11-19 Feng, H.,Ding, J.,Zhu, D.,Liu, X.,Xu, X.,Zhang, Y.,Zang, S.,Wang, D.C.,Liu, W. Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins. J.Am.Chem.Soc. 2014 136 14694 14697 4WQN 25412661 Crystal structure of N6-methyladenosine RNA reader YTHDF2 2014-10-22 2014-11-19 Zhu, T.,Roundtree, I.A.,Wang, P.,Wang, X.,Wang, L.,Sun, C.,Tian, Y.,Li, J.,He, C.,Xu, Y. Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res. 2014 24 1493 1496 4WQN 25412661 Crystal structure of N6-methyladenosine RNA reader YTHDF2 2014-10-22 2014-11-19 Zhu, T.,Roundtree, I.A.,Wang, P.,Wang, X.,Wang, L.,Sun, C.,Tian, Y.,Li, J.,He, C.,Xu, Y. Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res. 2014 24 1493 1496 4R3Q 25394919 Crystal structure of SYCE3 2014-08-17 2014-11-26 Lu, J.,Gu, Y.,Feng, J.,Zhou, W.,Yang, X.,Shen, Y. Structural insight into the central element assembly of the synaptonemal complex Sci Rep 2014 4 7059 7059 4RLV 25383926 Crystal Structure of AnkB 24 Ankyrin Repeats in Complex with AnkR Autoinhibition Segment 2014-10-18 2014-11-26 Wang, C.,Wei, Z.,Chen, K.,Ye, F.,Yu, C.,Bennett, V.,Zhang, M. Structural basis of diverse membrane target recognitions by ankyrins. Elife 2014 3 0 0 4RLY 25383926 Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain 2014-10-18 2014-11-26 Wang, C.,Wei, Z.,Chen, K.,Ye, F.,Yu, C.,Bennett, V.,Zhang, M. Structural basis of diverse membrane target recognitions by ankyrins. Elife 2014 3 0 0 4WSI 25385611 Crystal Structure of PALS1/Crb complex 2014-10-28 2014-11-26 Li, Y.,Wei, Z.,Yan, Y.,Wan, Q.,Du, Q.,Zhang, M. Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. Proc.Natl.Acad.Sci.USA 2014 111 17444 17449 3WNV 24835102 Crystal structure of a glyoxylate reductase from Paecilomyes thermophila 2013-12-17 2014-12-03 Duan, X.,Hu, S.,Zhou, P.,Zhou, Y.,Liu, Y.,Jiang, Z. Characterization and crystal structure of a first fungal glyoxylate reductase from Paecilomyes thermophila Enzyme.Microb.Technol. 2014 60 72 79 4NZW 24746913 Crystal Structure of STK25-MO25 Complex 2013-12-13 2014-12-03 Hao, Q.,Feng, M.,Shi, Z.,Li, C.,Chen, M.,Wang, W.,Zhang, M.,Jiao, S.,Zhou, Z. Structural insights into regulatory mechanisms of MO25-mediated kinase activation. J.Struct.Biol. 2014 186 224 233 4O27 24746913 Crystal structure of MST3-MO25 complex with WIF motif 2013-12-16 2014-12-03 Hao, Q.,Feng, M.,Shi, Z.,Li, C.,Chen, M.,Wang, W.,Zhang, M.,Jiao, S.,Zhou, Z. Structural insights into regulatory mechanisms of MO25-mediated kinase activation. J.Struct.Biol. 2014 186 224 233 4QKN 25452335 Crystal structure of FTO bound to a selective inhibitor 2014-06-07 2014-12-03 Huang, Y.,Yan, J.,Li, Q.,Li, J.,Gong, S.,Zhou, H.,Gan, J.,Jiang, H.,Jia, G.F.,Luo, C.,Yang, C.G. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 43 373 384 4R29 25412445 Crystal structure of bacterial cysteine methyltransferase effector NleE 2014-08-11 2014-12-03 Yao, Q.,Zhang, L.,Wan, X.,Chen, J.,Hu, L.,Ding, X.,Li, L.,Karar, J.,Peng, H.,Chen, S.,Huang, N.,Rauscher, F.J.,Shao, F. Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway. Plos Pathog. 2014 10 0 0 4R8G 25437912 Crystal Structure of Myosin-1c tail in complex with Calmodulin 2014-09-02 2014-12-03 Lu, Q.,Li, J.,Ye, F.,Zhang, M. Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nat.Struct.Mol.Biol. 2015 22 81 88 4RS6 25511705 Crystal structure of the C domain of Polo like Kinase II in Homo Sapiens 2014-11-07 2014-12-03 Shan, H.M.,Wang, T.,Quan, J.M. Crystal structure of the polo-box domain of polo-like kinase 2 Biochem.Biophys.Res.Commun. 2015 456 780 784 4NUR Crystal structure of thermostable alkylsulfatase SdsAP from Pseudomonas sp. S9 2013-12-04 2014-12-10 Wu, Y.K.,Sun, L.F. Crystal structure of thermostable alkylsulfatase SdsAP from Pseudomonas sp. S9 To be Published 0 0 0 0 4NYL Crystal structure of adalimumab FAB fragment 2013-12-10 2014-12-10 Fan, L.J. Crystal structure of adalimumab FAB fragment To be Published 0 0 0 0 4O6P 25460918 Structural and functional studies the characterization of C58G/C70G mutant in Cys4 Zinc-finger motif in the recombination mediator protein RecR 2013-12-23 2014-12-10 Tang, Q.,Liu, Y.P.,Yan, X.X.,Liang, D.C. Structural and functional characterization of Cys4 zinc finger motif in the recombination mediator protein RecR. DNA Repair (Amst.) 2014 24 10 14 4TTP 25449315 Crystal structure of Legionella pneumophila dephospho-CoA kinase in apo-form 2014-06-22 2014-12-10 Gong, X.,Chen, X.,Yu, D.,Zhang, N.,Zhu, Z.,Niu, L.,Mao, Y.,Ge, H. Crystal structure of Legionella pneumophila dephospho-CoA kinase reveals a non-canonical conformation of P-loop. J.Struct.Biol. 2014 188 233 239 4TTQ 25449315 Crystal structure of Legionella pneumophila dephospho-CoA kinase in complex with ATP 2014-06-22 2014-12-10 Gong, X.,Chen, X.,Yu, D.,Zhang, N.,Zhu, Z.,Niu, L.,Mao, Y.,Ge, H. Crystal structure of Legionella pneumophila dephospho-CoA kinase reveals a non-canonical conformation of P-loop. J.Struct.Biol. 2014 188 233 239 4TTR 25449315 Crystal structure of Legionella pneumophila dephospho-CoA kinase in complex with Bu2 2014-06-22 2014-12-10 Gong, X.,Chen, X.,Yu, D.,Zhang, N.,Zhu, Z.,Niu, L.,Mao, Y.,Ge, H. Crystal structure of Legionella pneumophila dephospho-CoA kinase reveals a non-canonical conformation of P-loop. J.Struct.Biol. 2014 188 233 239 4X0R 25446123 Crystal structure of human MxB stalk domain 2014-11-23 2014-12-10 Xu, B.,Kong, J.,Wang, X.,Wei, W.,Xie, W.,Yu, X.F. Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2. Biochem.Biophys.Res.Commun. 2015 456 197 201 3WY7 25462832 Crystal structure of Mycobacterium smegmatis 7-Keto-8-aminopelargonic acid (KAPA) synthase BioF 2014-08-20 2014-12-17 Fan, S.H.,Li, D.F.,Wang, D.C.,Fleming, J.,Zhang, H.T.,Zhou, Y.,Zhou, L.,Zhou, J.,Chen, T.,Chen, G.J.,Zhang, X.E.,Bi, L.J. Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase Int.J.Biochem.Cell Biol. 2014 0 71 80 4O0S Crystal structures of human kinase Aurora A 2013-12-14 2014-12-17 Zhang, L.,Wang, J.,Hou, L.,Cao, P.,Wu, L.,Zang, Y.,Ding, J.,Li, J. Functional Role of Conserved HxD-histidine in the Catalytic Core of Protein Kinases To be Published 0 0 0 0 4O0U Crystal structures of human kinase Aurora A 2013-12-14 2014-12-17 Zhang, L.,Wang, J.,Hou, L.,Cao, P.,Wu, L.,Zang, Y.,Ding, J.,Li, J. Functional Role of Conserved HxD-histidine in the Catalytic Core of Protein Kinases To be Published 0 0 0 0 4O0W Crystal structures of human kinase Aurora A 2013-12-14 2014-12-17 Zhang, L.,Wang, J.,Hou, L.,Cao, P.,Wu, L.,Zang, Y.,Ding, J.,Li, J. Functional Role of Conserved HxD-histidine in the Catalytic Core of Protein Kinase To be Published 0 0 0 0 4Q79 25453093 Structure of a HG-derivative CsgG 2014-04-24 2014-12-17 Cao, B.,Zhao, Y.,Kou, Y.,Ni, D.,Zhang, X.C.,Huang, Y. Structure of the nonameric bacterial amyloid secretion channel Proc.Natl.Acad.Sci.USA 2014 111 0 0 4R1D 25478841 The crystal structure of Tle4-Tli4 complex 2014-08-05 2014-12-17 Lu, D.,Zheng, Y.,Liao, N.,Wei, L.,Xu, B.,Liu, X.,Liu, J. The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa. Acta Crystallogr.,Sect.D 2014 70 3233 3243 4RC6 25482408 Crystal structure of cyanobacterial aldehyde-deformylating oxygenase 122F mutant 2014-09-14 2014-12-17 Jia, C.,Li, M.,Li, J.,Zhang, J.,Zhang, H.,Cao, P.,Pan, X.,Lu, X.,Chang, W. Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases. Protein Cell 2015 6 55 67 4RC7 25482408 Crystal structure of cyanobacterial aldehyde-deformylating oxygenase F86YF87Y mutant 2014-09-14 2014-12-17 Jia, C.,Li, M.,Li, J.,Zhang, J.,Zhang, H.,Cao, P.,Pan, X.,Lu, X.,Chang, W. Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases. Protein Cell 2015 6 55 67 4RQP 25492868 Crystal structure of the natually occurring empty particle of a clinical C4 strain EV71 2014-11-04 2014-12-17 Lyu, K.,Wang, G.C.,He, Y.L.,Han, J.F.,Ye, Q.,Qin, C.F.,Chen, R. Crystal structures of enterovirus 71 (EV71) recombinant virus particles provide insights into vaccine design. J.Biol.Chem. 2015 290 3198 3208 4RQU 25447145 Alcohol Dehydrogenase crystal structure in complex with NAD 2014-11-05 2014-12-17 Chen, F.,Wang, P.,An, Y.,Huang, J.,Xu, Y. Structural insight into the conformational change of alcohol dehydrogenase from arabidopsis Thalianal during coenzyme binding. Biochimie 2014 0 33 39 4RR3 25492868 Crystal structure of a recombinant EV71 virus particle 2014-11-06 2014-12-17 Lyu, K.,Wang, G.C.,He, Y.L.,Han, J.F.,Ye, Q.,Qin, C.F.,Chen, R. Crystal structures of enterovirus 71 (EV71) recombinant virus particles provide insights into vaccine design. J.Biol.Chem. 2015 290 3198 3208 4RS5 25492868 Crystal structure of an uncoating intermediate of a EV71 recombinant virus 2014-11-07 2014-12-17 Lyu, K.,Wang, G.C.,He, Y.L.,Han, J.F.,Ye, Q.,Qin, C.F.,Chen, R. Crystal structures of enterovirus 71 (EV71) recombinant virus particles provide insights into vaccine design. J.Biol.Chem. 2015 290 3198 3208 4QAH 25450460 The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 2014-05-05 2014-12-24 Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol. 2014 0 84 95 4QBE 25450460 The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 2014-05-08 2014-12-24 Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol. 2014 0 84 95 4RDN 25412658 Structure of YTH-YTHDF2 in complex with m6A 2014-09-19 2014-12-24 Li, F.,Zhao, D.,Wu, J.,Shi, Y. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. Cell Res. 2014 24 1490 1492 4RDO 25412658 Structure of YTH-YTHDF2 in the free state 2014-09-19 2014-12-24 Li, F.,Zhao, D.,Wu, J.,Shi, Y. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. Cell Res. 2014 24 1490 1492 4RFS 25512487 Structure of a pantothenate energy coupling factor transporter 2014-09-27 2014-12-24 Zhang, M.,Bao, Z.,Zhao, Q.,Guo, H.,Xu, K.,Wang, C.,Zhang, P. Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters. Proc.Natl.Acad.Sci.USA 2014 111 18560 18565 4ROV 25542899 The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA 2014-10-29 2014-12-31 Lu, X.,Zhang, T.,Xu, Z.,Liu, S.,Zhao, B.,Lan, W.,Wang, C.,Ding, J.,Cao, C. Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA J.Biol.Chem. 2015 290 4010 4021 4ROW 25542899 The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA 2014-10-29 2014-12-31 Lu, X.,Zhang, T.,Xu, Z.,Liu, S.,Zhao, B.,Lan, W.,Wang, C.,Ding, J.,Cao, C. Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA J.Biol.Chem. 2015 290 4010 4021 4U1T 25404066 The crystal structure of holo CalE6, a methionine gamma lyase from Micromonospora echinospora 2014-07-16 2015-01-07 Song, H.,Xu, R.,Guo, Z. Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora Chembiochem 2015 16 100 109 4U2H 25404066 The crystal structure of apo CalE6, a methionine gamma lyase from Micromonospora echinospora 2014-07-17 2015-01-07 Song, H.,Xu, R.,Guo, Z. Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora Chembiochem 2015 16 100 109 4PPM 24704447 Crystal structure of PigE: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14 2014-02-27 2015-01-14 Lou, X.D.,Ran, T.T.,Han, N.,Gao, Y.,He, J.,Tang, L.,Xu, D.Q.,Wang, W.W. Crystal structure of the catalytic domain of PigE: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14 Biochem.Biophys.Res.Commun. 2014 447 178 183 4PQ6 25969804 A sperm whale myoglobin single mutant L29E Mb with native His93 coordination 2014-02-28 2015-01-14 Du, J.F.,Li, W.,Li, L.,Wen, G.B.,Lin, Y.W.,Tan, X. Regulating the coordination state of a heme protein by a designed distal hydrogen-bonding network. ChemistryOpen 2015 4 97 101 4PQ6 25969804 A sperm whale myoglobin single mutant L29E Mb with native His93 coordination 2014-02-28 2015-01-14 Du, J.F.,Li, W.,Li, L.,Wen, G.B.,Lin, Y.W.,Tan, X. Regulating the coordination state of a heme protein by a designed distal hydrogen-bonding network. ChemistryOpen 2015 4 97 101 4PQB 25969804 A sperm whale myoglobin double mutant L29E/F43H Mb with a non-native bis-His (His64/His93) coordination 2014-03-01 2015-01-14 Du, J.F.,Li, W.,Li, L.,Wen, G.B.,Lin, Y.W.,Tan, X. Regulating the coordination state of a heme protein by a designed distal hydrogen-bonding network. ChemistryOpen 2015 4 97 101 4PQB 25969804 A sperm whale myoglobin double mutant L29E/F43H Mb with a non-native bis-His (His64/His93) coordination 2014-03-01 2015-01-14 Du, J.F.,Li, W.,Li, L.,Wen, G.B.,Lin, Y.W.,Tan, X. Regulating the coordination state of a heme protein by a designed distal hydrogen-bonding network. ChemistryOpen 2015 4 97 101 4PQC 25969804 A sperm whale myoglobin single mutant F43H Mb with native His93 coordination 2014-03-02 2015-01-14 Du, J.F.,Li, W.,Li, L.,Wen, G.B.,Lin, Y.W.,Tan, X. Regulating the coordination state of a heme protein by a designed distal hydrogen-bonding network. ChemistryOpen 2015 4 97 101 4PXQ 25568314 Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide 2014-03-24 2015-01-14 Qin, Y.,Ke, J.,Gu, X.,Fang, J.,Wang, W.,Cong, Q.,Li, J.,Tan, J.,Brunzelle, J.S.,Zhang, C.,Jiang, Y.,Melcher, K.,Li, J.P.,Xu, H.E.,Ding, K. Structural and Functional Study of d-Glucuronyl C5-epimerase. J.Biol.Chem. 2015 290 4620 4630 4R7A 25601084 Crystal Structure of RBBP4 bound to PHF6 peptide 2014-08-27 2015-01-14 Liu, Z.,Li, F.,Zhang, B.,Li, S.,Wu, J.,Shi, Y. Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by the Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex J.Biol.Chem. 2015 290 6630 6638 4RDL 25547362 Crystal structure of Norovirus Boxer P domain in complex with Lewis y tetrasaccharide 2014-09-19 2015-01-14 Hao, N.,Chen, Y.,Xia, M.,Tan, M.,Liu, W.,Guan, X.,Jiang, X.,Li, X.,Rao, Z. Crystal structures of GI.8 Boxer virus P dimers in complex with HBGAs, a novel evolutionary path selected by the Lewis epitope. Protein Cell 2015 6 101 116 4UX5 25550425 Structure of DNA complex of PCG2 2014-08-19 2015-01-14 Liu, J.,Huang, J.,Zhao, Y.,Liu, H.,Wang, D.,Yang, J.,Zhao, W.,Taylor, I.A.,Peng, Y. Structural Basis of DNA Recognition by Pcg2 Reveals a Novel DNA Binding Mode for Winged Helix-Turn-Helix Domains. Nucleic Acids Res. 2015 43 1231 0 4WNZ 25541196 Crystal structure of Pyrococcus furiosus Cmr4 (Cas7) 2014-10-15 2015-01-14 Zhu, X.,Ye, K. Cmr4 is the slicer in the RNA-targeting Cmr CRISPR complex Nucleic Acids Res. 2015 43 1257 1267 3X2R 25453093 Structure of the nonameric bacterial amyloid secretion channel CsgG 2014-12-29 2015-01-21 Cao, B.,Zhao, Y.,Kou, Y.,Ni, D.,Zhang, X.C.,Huang, Y. Structure of the nonameric bacterial amyloid secretion channel Proc.Natl.Acad.Sci.USA 2014 111 0 0 4OIC 24743650 Crystal structrual of a soluble protein 2014-01-19 2015-01-21 He, Y.,Hao, Q.,Li, W.,Yan, C.,Yan, N.,Yin, P. Identification and characterization of ABA receptors in Oryza sativa Plos One 2014 9 0 0 4QAU 25392956 Crystal structure of F43Y mutant of sperm whale myoglobin 2014-05-06 2015-01-21 Yan, D.-J.,Li, W.,Xiang, Y.,Wen, G.-B.,Lin, Y.-W.,Tan, X. A Novel Tyrosine-Heme C-O Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins Chembiochem 2015 16 47 50 4RKG 25452275 Structure of the MSL2 CXC domain bound with a non-specific (GC)6 DNA 2014-10-13 2015-01-21 Zheng, S.,Villa, R.,Wang, J.,Feng, Y.,Wang, J.,Becker, P.B.,Ye, K. Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation. Genes Dev. 2014 28 2652 2662 4RKH 25452275 Structure of the MSL2 CXC domain bound with a specific MRE sequence 2014-10-13 2015-01-21 Zheng, S.,Villa, R.,Wang, J.,Feng, Y.,Wang, J.,Becker, P.B.,Ye, K. Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation. Genes Dev. 2014 28 2652 2662 4W5A 25538301 Complex structure of ATRX ADD bound to H3K9me3S10ph peptide 2014-08-17 2015-01-21 Noh, K.M.,Maze, I.,Zhao, D.,Xiang, B.,Wenderski, W.,Lewis, P.W.,Shen, L.,Li, H.,Allis, C.D. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons Proc.Natl.Acad.Sci.USA 2015 112 6820 6827 4QFK 25605306 Crystal structure of dipeptide binding protein from pseudoalteromonas sp. SM9913 2014-05-21 2015-01-28 Li, C.Y.,Chen, X.L.,Qin, Q.L.,Wang, P.,Zhang, W.X.,Xie, B.B.,Su, H.N.,Zhang, X.Y.,Zhou, B.C.,Zhang, Y.Z. Structural insights into the multispecific recognition of dipeptides of deep-sea gram-negative bacterium Pseudoalteromonas sp. strain SM9913 J. Bacteriol. 2015 197 1125 1134 4QFL 25605306 Crystal structure of dipeptide binding protein from pseudoalteromonas sp. SM9913 in complex with Ala-Phe 2014-05-21 2015-01-28 Li, C.Y.,Chen, X.L.,Qin, Q.L.,Wang, P.,Zhang, W.X.,Xie, B.B.,Su, H.N.,Zhang, X.Y.,Zhou, B.C.,Zhang, Y.Z. Structural insights into the multispecific recognition of dipeptides of deep-sea gram-negative bacterium Pseudoalteromonas sp. strain SM9913 J. Bacteriol. 2015 197 1125 1134 4QFN 25605306 Crystal structure of dipeptide binding protein from pseudoalteromonas sp. SM9913 in complex with Gly-Glu 2014-05-21 2015-01-28 Li, C.Y.,Chen, X.L.,Qin, Q.L.,Wang, P.,Zhang, W.X.,Xie, B.B.,Su, H.N.,Zhang, X.Y.,Zhou, B.C.,Zhang, Y.Z. Structural insights into the multispecific recognition of dipeptides of deep-sea gram-negative bacterium Pseudoalteromonas sp. strain SM9913 J. Bacteriol. 2015 197 1125 1134 4QFO 25605306 Crystal structure of dipeptide binding protein from pseudoalteromonas sp. SM9913 in complex with Met-Leu 2014-05-21 2015-01-28 Li, C.Y.,Chen, X.L.,Qin, Q.L.,Wang, P.,Zhang, W.X.,Xie, B.B.,Su, H.N.,Zhang, X.Y.,Zhou, B.C.,Zhang, Y.Z. Structural insights into the multispecific recognition of dipeptides of deep-sea gram-negative bacterium Pseudoalteromonas sp. strain SM9913 J. Bacteriol. 2015 197 1125 1134 4QFP 25605306 Crystal structure of dipeptide binding protein from pseudoalteromonas sp. SM9913 in complex with Val-Thr 2014-05-21 2015-01-28 Li, C.Y.,Chen, X.L.,Qin, Q.L.,Wang, P.,Zhang, W.X.,Xie, B.B.,Su, H.N.,Zhang, X.Y.,Zhou, B.C.,Zhang, Y.Z. Structural insights into the multispecific recognition of dipeptides of deep-sea gram-negative bacterium Pseudoalteromonas sp. strain SM9913 J. Bacteriol. 2015 197 1125 1134 4QY0 25574798 Structure of H10 from human-infecting H10N8 2014-07-23 2015-01-28 Wang, M.,Zhang, W.,Qi, J.,Wang, F.,Zhou, J.,Bi, Y.,Wu, Y.,Sun, H.,Liu, J.,Huang, C.,Li, X.,Yan, J.,Shu, Y.,Shi, Y.,Gao, G.F. Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus Nat Commun 2015 6 5600 5600 4QY1 25574798 Structure of H10 from human-infecting H10N8 in complex with avian receptor 2014-07-23 2015-01-28 Wang, M.,Zhang, W.,Qi, J.,Wang, F.,Zhou, J.,Bi, Y.,Wu, Y.,Sun, H.,Liu, J.,Huang, C.,Li, X.,Yan, J.,Shu, Y.,Shi, Y.,Gao, G.F. Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus Nat Commun 2015 6 5600 5600 4QY2 25574798 Structure of H10 from human-infecting H10N8 virus in complex with human receptor analog 2014-07-23 2015-01-28 Wang, M.,Zhang, W.,Qi, J.,Wang, F.,Zhou, J.,Bi, Y.,Wu, Y.,Sun, H.,Liu, J.,Huang, C.,Li, X.,Yan, J.,Shu, Y.,Shi, Y.,Gao, G.F. Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus Nat Commun 2015 6 5600 5600 4R4X Structure of PNGF-II in C2 space group 2014-08-20 2015-01-28 Sun, G.,Yu, X.,Celimuge,Wang, L.,Li, M.,Gan, J.,Qu, D.,Ma, J.,Chen, L. Identification and Characterization of a Novel Prokaryotic Peptide: N-glycosidase from Elizabethkingia meningoseptica J.Biol.Chem. 2015 0 0 0 4R4Z Structure of PNGF-II in P21 space group 2014-08-20 2015-01-28 Sun, G.,Yu, X.,Celimuge,Wang, L.,Li, M.,Gan, J.,Qu, D.,Ma, J.,Chen, L. Identification and Characterization of a Novel Prokaryotic Peptide: N-glycosidase from Elizabethkingia meningoseptica J.Biol.Chem. 2015 0 0 0 4RL1 25581064 Structural and functional analysis of a loading acyltransferase from the avermectin modular polyketide synthase 2014-10-15 2015-01-28 Wang, F.,Wang, Y.,Ji, J.,Zhou, Z.,Yu, J.,Zhu, H.,Su, Z.,Zhang, L.,Zheng, J. Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. Acs Chem.Biol. 2015 10 1017 1025 4RY3 25547363 Crystal structure of human Fanconi-associated nuclease 1 2014-12-13 2015-01-28 Yan, P.X.,Huo, Y.G.,Jiang, T. Crystal structure of human Fanconi-associated nuclease 1. Protein Cell 2015 6 225 228 4X2Z 25609249 Structural view and substrate specificity of papain-like protease from Avian Infectious Bronchitis Virus 2014-11-27 2015-01-28 Kong, L.,Shaw, N.,Yan, L.,Lou, Z.,Rao, Z. Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus. J.Biol.Chem. 2015 290 7160 7168 4LYG 25781187 Crystal structure of human PRS1 E43T mutant 2013-07-31 2015-02-04 Chen, P.,Liu, Z.,Wang, X.,Peng, J.,Sun, Q.,Li, J.,Wang, M.,Niu, L.,Zhang, Z.,Cai, G.,Teng, M.,Li, X. Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One 2015 10 0 0 4LZN 25781187 Crystal structure of human PRS1 D65N mutant 2013-07-31 2015-02-04 Chen, P.,Liu, Z.,Wang, X.,Peng, J.,Sun, Q.,Li, J.,Wang, M.,Niu, L.,Zhang, Z.,Cai, G.,Teng, M.,Li, X. Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One 2015 10 0 0 4LZO 25781187 Crystal structure of human PRS1 A87T mutant 2013-07-31 2015-02-04 Chen, P.,Liu, Z.,Wang, X.,Peng, J.,Sun, Q.,Li, J.,Wang, M.,Niu, L.,Zhang, Z.,Cai, G.,Teng, M.,Li, X. Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One 2015 10 0 0 4M0P 25781187 Crystal structure of human PRS1 M115T mutant 2013-08-01 2015-02-04 Chen, P.,Liu, Z.,Wang, X.,Peng, J.,Sun, Q.,Li, J.,Wang, M.,Niu, L.,Zhang, Z.,Cai, G.,Teng, M.,Li, X. Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One 2015 10 0 0 4M0U 25781187 crystal structure of human PRS1 Q133P mutant 2013-08-02 2015-02-04 Chen, P.,Liu, Z.,Wang, X.,Peng, J.,Sun, Q.,Li, J.,Wang, M.,Niu, L.,Zhang, Z.,Cai, G.,Teng, M.,Li, X. Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One 2015 10 0 0 4ORD Crystal Structure of Zebra Fish Thioesterase Superfamily Member 2 2014-02-11 2015-02-11 Yu, S.S.,Li, H.,Gao, F.,Wang, Y.,Miao, L.Y.,Zhang, J.,Xu, H.,Gong, W.M. Crystal Structure and Potential Physiological Role of Zebra Fish Thioesterase Superfamily Member 2 (fTHEM2) To be Published 0 0 0 0 4QAP 25450460 The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 2014-05-05 2015-02-11 Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol. 2014 57 84 95 4QBW 25450460 The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 2014-05-08 2015-02-11 Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol. 2014 57 84 95 4QS7 25664748 Arabidopsis Hexokinase 1 (AtHXK1) structure in glucose-bound form 2014-07-03 2015-02-11 Feng, J.,Zhao, S.,Chen, X.,Wang, W.,Dong, W.,Chen, J.,Shen, J.-R.,Liu, L.,Kuang, T. Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D 2015 71 367 375 4QS8 25664748 Arabidopsis Hexokinase 1 (AtHXK1) structure in ligand-free form 2014-07-03 2015-02-11 Feng, J.,Zhao, S.,Chen, X.,Wang, W.,Dong, W.,Chen, J.,Shen, J.-R.,Liu, L.,Kuang, T. Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D 2015 71 367 375 4QS9 25664748 Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form 2014-07-03 2015-02-11 Feng, J.,Zhao, S.,Chen, X.,Wang, W.,Dong, W.,Chen, J.,Shen, J.-R.,Liu, L.,Kuang, T. Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D 2015 71 367 375 4WQ6 25556090 The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21) 2014-10-21 2015-02-11 Zak, M.,Liederer, B.M.,Sampath, D.,Yuen, P.W.,Bair, K.W.,Baumeister, T.,Buckmelter, A.J.,Clodfelter, K.H.,Cheng, E.,Crocker, L.,Fu, B.,Han, B.,Li, G.,Ho, Y.C.,Lin, J.,Liu, X.,Ly, J.,O'Brien, T.,Reynolds, D.J.,Skelton, N.,Smith, C.C.,Tay, S.,Wang, W.,Wang, Z.,Xiao, Y.,Zhang, L.,Zhao, G.,Zheng, X.,Dragovich, P.S. Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Bioorg.Med.Chem.Lett. 2015 25 529 541 4WVD 23728580 Identification of a novel FXR ligand that regulates metabolism 2014-11-05 2015-02-11 Jin, L.,Feng, X.,Rong, H.,Pan, Z.,Inaba, Y.,Qiu, L.,Zheng, W.,Lin, S.,Wang, R.,Wang, Z.,Wang, S.,Liu, H.,Li, S.,Xie, W.,Li, Y. The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism. Nat Commun 2013 4 1937 0 4OR4 25691568 Structure of Influenza B PB2 cap-binding domain with Q325F mutation complex with m7GDP 2014-02-10 2015-02-25 Liu, Y.,Yang, Y.,Fan, J.,He, R.,Luo, M.,Zheng, X. The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism. J.Biol.Chem. 2015 290 9141 9149 4OR6 25691568 Structure of Influenza B PB2 cap-binding domain with Q325F mutation complex with GDP 2014-02-11 2015-02-25 Liu, Y.,Yang, Y.,Fan, J.,He, R.,Luo, M.,Zheng, X. The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism. J.Biol.Chem. 2015 290 9141 9149 4P22 25209502 Crystal Structure of N-terminal Fragments of E1 2014-02-28 2015-02-25 Xie, S.T. Expression, purification, and crystal structure of N-terminal domains of human ubiquitin-activating enzyme (E1). Biosci.Biotechnol.Biochem. 2014 78 1542 1549 4Q46 25691568 The second structure of Influenza B PB2 cap-binding domain complex with GDP 2014-04-13 2015-02-25 Liu, Y.,Yang, Y.,Fan, J.,He, R.,Luo, M.,Zheng, X. The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism. J.Biol.Chem. 2015 290 9141 9149 4QG6 25645022 crystal structure of PKM2-Y105E mutant 2014-05-22 2015-02-25 Wang, P.,Sun, C.,Zhu, T.,Xu, Y. Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell 2015 6 275 287 4QG8 25645022 crystal structure of PKM2-K305Q mutant 2014-05-22 2015-02-25 Wang, P.,Sun, C.,Zhu, T.,Xu, Y. Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell 2015 6 275 287 4QG9 25645022 crystal structure of PKM2-R399E mutant 2014-05-22 2015-02-25 Wang, P.,Sun, C.,Zhu, T.,Xu, Y. Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell 2015 6 275 287 4QGC 25645022 crystal structure of PKM2-K422R mutant 2014-05-22 2015-02-25 Wang, P.,Sun, C.,Zhu, T.,Xu, Y. Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell 2015 6 275 287 4QTH 25659907 Crystal structure of anti-uPAR Fab 8B12 2014-07-08 2015-02-25 Zhao, B.,Gandhi, S.,Yuan, C.,Luo, Z.,Li, R.,Gardsvoll, H.,de Lorenzi, V.,Sidenius, N.,Huang, M.,Ploug, M. Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation. J.Mol.Biol. 2015 427 1389 1403 4QTI 25659907 Crystal structure of human uPAR in complex with anti-uPAR Fab 8B12 2014-07-08 2015-02-25 Zhao, B.,Gandhi, S.,Yuan, C.,Luo, Z.,Li, R.,Gardsvoll, H.,de Lorenzi, V.,Sidenius, N.,Huang, M.,Ploug, M. Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation. J.Mol.Biol. 2015 427 1389 1403 4RPP 25645022 crystal structure of PKM2-K422R mutant bound with FBP 2014-10-31 2015-02-25 Wang, P.,Sun, C.,Zhu, T.,Xu, Y. Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell 2015 6 275 287 4RP8 25686089 Bacterial vitamin C transporter UlaA/SgaT in P21 form 2014-10-29 2015-03-04 Luo, P.,Yu, X.,Wang, W.,Fan, S.,Li, X.,Wang, J. Crystal structure of a phosphorylation-coupled vitamin C transporter. Nat.Struct.Mol.Biol. 2015 22 238 241 4RP9 25686089 Bacterial vitamin C transporter UlaA/SgaT in C2 form 2014-10-29 2015-03-04 Luo, P.,Yu, X.,Wang, W.,Fan, S.,Li, X.,Wang, J. Crystal structure of a phosphorylation-coupled vitamin C transporter. Nat.Struct.Mol.Biol. 2015 22 238 241 4XH7 25662616 Crystal structure of MUPP1 PDZ4 2015-01-05 2015-03-04 Zhu, H.,Liu, Z.,Huang, Y.,Zhang, C.,Li, G.,Liu, W. Biochemical and structural characterization of MUPP1-PDZ4 domain from Mus musculus. Acta Biochim.Biophys.Sin. 2015 47 199 206 4Q2J 25124042 A novel structure-based mechanism for DNA-binding of SATB1 2014-04-08 2015-03-11 Wang, Z.,Yang, X.,Guo, S.,Yang, Y.,Su, X.C.,Shen, Y.,Long, J. Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. J.Biol.Chem. 2014 289 27376 27385 4R9A 25662390 Crystal structure of Human galectin-3 CRD in complex with lactose (pH 7.0, PEG4000) 2014-09-04 2015-03-11 Su, J.,Zhang, T.,Wang, P.,Liu, F.,Tai, G.,Zhou, Y. The water network in galectin-3 ligand binding site guides inhibitor design. Acta Biochim.Biophys.Sin. 2015 47 192 198 4R9B 25662390 Crystal structure of Human galectin-3 CRD in complex with lactose (pH 7.0, PEG 6000) 2014-09-04 2015-03-11 Su, J.,Zhang, T.,Wang, P.,Liu, F.,Tai, G.,Zhou, Y. The water network in galectin-3 ligand binding site guides inhibitor design. Acta Biochim.Biophys.Sin. 2015 47 192 198 4R9C 25662390 Crystal structure of Human galectin-3 CRD in complex with lactose (pH 7.5, PEG6000) 2014-09-04 2015-03-11 Su, J.,Zhang, T.,Wang, P.,Liu, F.,Tai, G.,Zhou, Y. The water network in galectin-3 ligand binding site guides inhibitor design. Acta Biochim.Biophys.Sin. 2015 47 192 198 4R9D 25662390 Crystal structure of Human galectin-3 CRD in complex with lactose (pH 7.9, PEG6000) 2014-09-04 2015-03-11 Su, J.,Zhang, T.,Wang, P.,Liu, F.,Tai, G.,Zhou, Y. The water network in galectin-3 ligand binding site guides inhibitor design. Acta Biochim.Biophys.Sin. 2015 47 192 198 4RL7 25662390 Crystal structure of Human galectin-3 CRD in complex with lactose (pH 7.5, PEG6000) 2014-10-16 2015-03-11 Su, J.,Zhang, T.,Wang, P.,Liu, F.,Tai, G.,Zhou, Y. The water network in galectin-3 ligand binding site guides inhibitor design. Acta Biochim.Biophys.Sin. 2015 47 192 198 4RTI 25704164 The crystal structure of PsbP from Spinacia oleracea 2014-11-15 2015-03-11 Cao, P.,Xie, Y.,Li, M.,Pan, X.,Zhang, H.,Zhao, X.,Su, X.,Cheng, T.,Chang, W. Crystal structure analysis of extrinsic PsbP protein of photosystem II reveals a manganese-induced conformational change. Mol Plant 2015 8 664 666 4RVZ 25694369 Crystal structure of tRNA fluorescent labeling enzyme 2014-11-29 2015-03-11 Li, F.,Dong, J.,Hu, X.,Gong, W.,Li, J.,Shen, J.,Tian, H.,Wang, J. A covalent approach for site-specific RNA labeling in Mammalian cells. Angew.Chem.Int.Ed.Engl. 2015 54 4597 4602 4RXP 25760601 The structure of GTP-dATP-bound SAMHD1 2014-12-11 2015-03-11 Zhu, C.F.,Wei, W.,Peng, X.,Dong, Y.H.,Gong, Y.,Yu, X.F. The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D 2015 71 516 524 4RXQ 25760601 The structure of GTP-dUTP-bound SAMHD1 2014-12-11 2015-03-11 Zhu, C.F.,Wei, W.,Peng, X.,Dong, Y.H.,Gong, Y.,Yu, X.F. The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D 2015 71 516 524 4RXR 25760601 The structure of GTP-dCTP-bound SAMHD1 2014-12-11 2015-03-11 Zhu, C.F.,Wei, W.,Peng, X.,Dong, Y.H.,Gong, Y.,Yu, X.F. The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D 2015 71 516 524 4WJA 25670504 Crystal Structure of PAXX 2014-09-29 2015-03-11 Xing, M.,Yang, M.,Huo, W.,Feng, F.,Wei, L.,Jiang, W.,Ning, S.,Yan, Z.,Li, W.,Wang, Q.,Hou, M.,Dong, C.,Guo, R.,Gao, G.,Ji, J.,Zha, S.,Lan, L.,Liang, H.,Xu, D. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun 2015 6 6233 6233 4PV7 Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor 2014-03-15 2015-03-18 Xiao, P.,Guo, R.,Huang, S.,Cui, H.,Ye, S.,Zhang, Z. Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold Chin.Chem.Lett. 2014 25 673 676 4RBL Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives 2014-09-12 2015-03-18 Zhang, W.,Wan, X.,Huang, N. Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives To be Published 2014 0 0 0 4RC2 Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives 2014-09-14 2015-03-18 Zhang, W.,Wan, X.,Huang, N. Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives To be Published 0 0 0 0 4RC3 Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives 2014-09-14 2015-03-18 Zhang, W.,Wan, X.,Huang, N. Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives To be Published 0 0 0 0 4RC4 Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives 2014-09-14 2015-03-18 Zhang, W.,Wan, X.,Huang, N. Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives To be Published 0 0 0 0 4RZE 25822914 Crystal Structure Analysis of the NUR77 Ligand Binding Domain, L437W,D594E mutant 2014-12-21 2015-03-18 Li, L.,Liu, Y.,Chen, H.Z.,Li, F.W.,Wu, J.F.,Zhang, H.K.,He, J.P.,Xing, Y.Z.,Chen, Y.,Wang, W.J.,Tian, X.Y.,Li, A.Z.,Zhang, Q.,Huang, P.Q.,Han, J.,Lin, T.,Wu, Q. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 2015 11 339 346 4RZF 25822914 Crystal Structure Analysis of the NUR77 Ligand Binding Domain, S441W mutant 2014-12-21 2015-03-18 Li, L.,Liu, Y.,Chen, H.Z.,Li, F.W.,Wu, J.F.,Zhang, H.K.,He, J.P.,Xing, Y.Z.,Chen, Y.,Wang, W.J.,Tian, X.Y.,Li, A.Z.,Zhang, Q.,Huang, P.Q.,Han, J.,Lin, T.,Wu, Q. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 2015 11 339 346 4RZG 25822914 Crystal Structure Analysis of the DNPA-bounded NUR77 Ligand binding Domain 2014-12-21 2015-03-18 Li, L.,Liu, Y.,Chen, H.Z.,Li, F.W.,Wu, J.F.,Zhang, H.K.,He, J.P.,Xing, Y.Z.,Chen, Y.,Wang, W.J.,Tian, X.Y.,Li, A.Z.,Zhang, Q.,Huang, P.Q.,Han, J.,Lin, T.,Wu, Q. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 2015 11 339 346 4USG 25739870 Crystal structure of PC4 W89Y mutant complex with DNA 2014-07-08 2015-03-18 Huang, J.,Zhao, Y.,Liu, H.,Huang, D.,Cheng, X.,Zhao, W.,Taylor, I.A.,Liu, J.,Peng, Y.L. Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4. Sci.Rep. 2015 5 8789 0 4OIV 26100621 Structural basis for small molecule NDB as a selective antagonist of FXR 2014-01-20 2015-03-25 Xu, X.,Xu, X.,Liu, P.,Zhu, Z.Y.,Chen, J.,Fu, H.A.,Chen, L.L.,Hu, L.H.,Shen, X. Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor. J.Biol.Chem. 2015 290 19888 19899 4PBP 25592778 crystal structure of zebrafish short-chain pentraxin protein 2014-04-13 2015-03-25 Chen, R.,Qi, J.,Yuan, H.,Wu, Y.,Hu, W.,Xia, C. Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces. J.Struct.Biol. 2015 189 259 268 4PXG Crystal Structure of TypeII restriction Enzyme Sau3AI 2014-03-24 2015-03-25 Xu, C.Y.,Yu, F.,Hu, X.J.,He, J.H. The 2.45 A Crystal Structure of the Restriction Endonuclease Sau3AI Suggests a Self-Inhibition Mechanism To be Published 0 0 0 0 4RDX 25722375 Structure of histidinyl-tRNA synthetase in complex with tRNA(His) 2014-09-20 2015-03-25 Tian, Q.,Wang, C.,Liu, Y.,Xie, W. Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase Nucleic Acids Res. 2015 43 2980 2990 4X1N 25545505 The crystal structure of mupain-1-16 in complex with murinised human uPA at pH7.4 2014-11-25 2015-03-25 Zhao, B.,Xu, P.,Jiang, L.,Paaske, B.,Kromann-Hansen, T.,Jensen, J.K.,Srensen, H.P.,Liu, Z.,Nielsen, J.T.,Christensen, A.,Hosseini, M.,Srensen, K.K.,Nielsen, N.C.,Jensen, K.J.,Huang, M.,Andreasen, P.A. A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One 2014 9 0 0 4X1Q 25545505 The crystal structure of mupain-1 in complex with murinised human uPA at pH7.4 2014-11-25 2015-03-25 Zhao, B.,Xu, P.,Jiang, L.,Paaske, B.,Kromann-Hansen, T.,Jensen, J.K.,Srensen, H.P.,Liu, Z.,Nielsen, J.T.,Christensen, A.,Hosseini, M.,Srensen, K.K.,Nielsen, N.C.,Jensen, K.J.,Huang, M.,Andreasen, P.A. A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One 2014 9 0 0 4XVC 25771540 Crystal structure of an esterase from the bacterial hormone-sensitive lipase (HSL) family 2015-01-27 2015-03-25 Li, P.Y.,Chen, X.L.,Ji, P.,Li, C.Y.,Wang, P.,Zhang, Y.,Xie, B.B.,Qin, Q.L.,Su, H.N.,Zhou, B.C.,Zhang, Y.Z.,Zhang, X.Y. Interdomain Hydrophobic Interactions Modulate the Thermostability of Microbial Esterases from the Hormone-Sensitive Lipase Family. J.Biol.Chem. 2015 290 11188 11198 4OEW 24702184 Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 2014-01-14 2015-04-01 Ren, J.,He, Y.,Chen, W.,Chen, T.,Wang, G.,Wang, Z.,Xu, Z.,Luo, X.,Zhu, W.,Jiang, H.,Shen, J.,Xu, Y. Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors. J.Med.Chem. 2014 57 3588 3593 4OEX 24702184 Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors 2014-01-14 2015-04-01 Ren, J.,He, Y.,Chen, W.,Chen, T.,Wang, G.,Wang, Z.,Xu, Z.,Luo, X.,Zhu, W.,Jiang, H.,Shen, J.,Xu, Y. Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors. J.Med.Chem. 2014 57 3588 3593 4PY4 Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2 2014-03-26 2015-04-01 Wang, P.,Li, J.,Jiang, X.,Liu, Z.,Ye, N.,Xu, Y.,Yang, G.,Xu, Y.,Zhang, A. Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors Tetrahedron 2017 70 5666 5673 4YL8 25792740 Crystal structure of the Crumbs/Moesin complex 2015-03-05 2015-04-01 Wei, Z.,Li, Y.,Ye, F.,Zhang, M. Structural Basis for the Phosphorylation-regulated Interaction between the Cytoplasmic Tail of Cell Polarity Protein Crumbs and the Actin-binding Protein Moesin J.Biol.Chem. 2015 290 11384 11392 4PLK 25793314 Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12 2014-05-18 2015-04-08 Gu, Y.,Tang, X.,Zhang, X.,Song, C.,Zheng, M.,Wang, K.,Zhang, J.,Ng, M.H.,Hew, C.L.,Li, S.,Xia, N.,Sivaraman, J. Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody Cell Res. 2015 25 604 620 4PQD The longer crystal structure of the grow factor like domain from Beta amypoid precusor protein (APP22-126) 2014-03-02 2015-04-08 Tan, X.,Li, W.,Wang, Z. Mapping the interaction betwwen APP and DR6 To be Published 0 0 0 0 4RF6 25849389 Crystal structure of double-domain arginine kinase from Anthopleura japonicas 2014-09-25 2015-04-08 Wang, Z.,Qiao, Z.,Ye, S.,Zhang, R. Structure of a double-domain phosphagen kinase reveals an asymmetric arrangement of the tandem domains. Acta Crystallogr.,Sect.D 2015 71 779 789 4RF8 25849389 Crystal structure of double-domain arginine kinase from Anthopleura japonicas in complex with ADP 2014-09-25 2015-04-08 Wang, Z.,Qiao, Z.,Ye, S.,Zhang, R. Structure of a double-domain phosphagen kinase reveals an asymmetric arrangement of the tandem domains. Acta Crystallogr.,Sect.D 2015 71 779 789 4RF9 25849389 Crystal structure of double-domain arginine kinase from Anthopleura japonicas in complex with L-arginine and ATPgS 2014-09-25 2015-04-08 Wang, Z.,Qiao, Z.,Ye, S.,Zhang, R. Structure of a double-domain phosphagen kinase reveals an asymmetric arrangement of the tandem domains. Acta Crystallogr.,Sect.D 2015 71 779 789 4X1B 25854324 Human serum transferrin with ferric ion bound at the C-lobe only 2014-11-24 2015-04-08 Wang, M.,Lai, T.P.,Wang, L.,Zhang, H.,Yang, N.,Sadler, P.J.,Sun, H. ""Anion clamp"" allows flexible protein to impose coordination geometry on metal ions Chem.Commun.(Camb.) 2015 51 7867 7870 4X1D 25854324 Ytterbium-bound human serum transferrin 2014-11-24 2015-04-08 Wang, M.,Lai, T.P.,Wang, L.,Zhang, H.,Yang, N.,Sadler, P.J.,Sun, H. ""Anion clamp"" allows flexible protein to impose coordination geometry on metal ions Chem.Commun.(Camb.) 2015 51 7867 7870 4PLJ 25793314 Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing antibody 8G12 2014-05-18 2015-04-15 Gu, Y.,Tang, X.,Zhang, X.,Song, C.,Zheng, M.,Wang, K.,Zhang, J.,Ng, M.H.,Hew, C.L.,Li, S.,Xia, N.,Sivaraman, J. Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody Cell Res. 2015 25 604 620 4Q2V 25847243 Crystal Structure of Ricin A chain complexed with Baicalin inhibitor 2014-04-10 2015-04-15 Dong, J.,Zhang, Y.,Chen, Y.,Niu, X.,Zhang, Y.,Li, R.,Yang, C.,Wang, Q.,Li, X.,Deng, X. Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization. J.Biol.Chem. 2015 290 12899 12907 4R0M 25849398 Structure of McyG A-PCP complexed with phenylalanyl-adenylate 2014-08-01 2015-04-15 Tan, X.F.,Dai, Y.N.,Zhou, K.,Jiang, Y.L.,Ren, Y.M.,Chen, Y.,Zhou, C.Z. Structure of the adenylation-peptidyl carrier protein didomain of the Microcystis aeruginosa microcystin synthetase McyG. Acta Crystallogr.,Sect.D 2015 71 873 881 4YVS 25833050 crystal structure of the virus-like particle of a c4 strain EV71 2015-03-20 2015-04-15 Lyu, K.,He, Y.L.,Li, H.Y.,Chen, R. Crystal Structures of Yeast-Produced Enterovirus 71 and Enterovirus 71/Coxsackievirus A16 Chimeric Virus-Like Particles Provide the Structural Basis for Novel Vaccine Design against Hand-Foot-and-Mouth Disease J.Virol. 2015 89 6196 6208 4YVW 25833050 crystal structure of an enterovirus 71/coxsackievirus A16 chimeric virus-like particle 2015-03-20 2015-04-15 Lyu, K.,He, Y.L.,Li, H.Y.,Chen, R. Crystal Structures of Yeast-Produced Enterovirus 71 and Enterovirus 71/Coxsackievirus A16 Chimeric Virus-Like Particles Provide the Structural Basis for Novel Vaccine Design against Hand-Foot-and-Mouth Disease J.Virol. 2015 89 6196 6208 4O8Z Crystal structure of human SIRT3 in complex with compound (2-butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone 2013-12-31 2015-04-22 Liu, B. Crystal structure of human SIRT3 in complex with compound (2-butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone To be Published 0 0 0 0 4Y2H 26101569 Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and an aryl pyrazole inhibitor 2015-02-09 2015-04-22 Mitchell, L.H.,Drew, A.E.,Ribich, S.A.,Rioux, N.,Swinger, K.K.,Jacques, S.L.,Lingaraj, T.,Boriack-Sjodin, P.A.,Waters, N.J.,Wigle, T.J.,Moradei, O.,Jin, L.,Riera, T.,Porter-Scott, M.,Moyer, M.P.,Smith, J.J.,Chesworth, R.,Copeland, R.A. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. Acs Med.Chem.Lett. 2015 6 655 659 4Y30 26101569 Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and EPZ020411 2015-02-10 2015-04-22 Mitchell, L.H.,Drew, A.E.,Ribich, S.A.,Rioux, N.,Swinger, K.K.,Jacques, S.L.,Lingaraj, T.,Boriack-Sjodin, P.A.,Waters, N.J.,Wigle, T.J.,Moradei, O.,Jin, L.,Riera, T.,Porter-Scott, M.,Moyer, M.P.,Smith, J.J.,Chesworth, R.,Copeland, R.A. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. Acs Med.Chem.Lett. 2015 6 655 659 4YMS 25848002 Crystal structure of an amino acid ABC transporter 2015-03-07 2015-04-22 Yu, J.,Ge, J.,Heuveling, J.,Schneider, E.,Yang, M. Structural basis for substrate specificity of an amino acid ABC transporter Proc.Natl.Acad.Sci.USA 2015 112 5243 5248 4YMT 25848002 Crystal structure of an amino acid ABC transporter complex with arginines 2015-03-07 2015-04-22 Yu, J.,Ge, J.,Heuveling, J.,Schneider, E.,Yang, M. Structural basis for substrate specificity of an amino acid ABC transporter Proc.Natl.Acad.Sci.USA 2015 112 5243 5248 4YMU 25848002 Crystal structure of an amino acid ABC transporter complex with arginines and ATPs 2015-03-07 2015-04-22 Yu, J.,Ge, J.,Heuveling, J.,Schneider, E.,Yang, M. Structural basis for substrate specificity of an amino acid ABC transporter Proc.Natl.Acad.Sci.USA 2015 112 5243 5248 4YMV 25848002 Crystal structure of an amino acid ABC transporter with ATPs 2015-03-07 2015-04-22 Yu, J.,Ge, J.,Heuveling, J.,Schneider, E.,Yang, M. Structural basis for substrate specificity of an amino acid ABC transporter Proc.Natl.Acad.Sci.USA 2015 112 5243 5248 4YMW 25848002 Crystal structure of an amino acid ABC transporter with histidines 2015-03-07 2015-04-22 Yu, J.,Ge, J.,Heuveling, J.,Schneider, E.,Yang, M. Structural basis for substrate specificity of an amino acid ABC transporter Proc.Natl.Acad.Sci.USA 2015 112 5243 5248 4YMX 25848002 Crystal structure of the substrate binding protein of an amino acid ABC transporter 2015-03-07 2015-04-22 Yu, J.,Ge, J.,Heuveling, J.,Schneider, E.,Yang, M. Structural basis for substrate specificity of an amino acid ABC transporter Proc.Natl.Acad.Sci.USA 2015 112 5243 5248 4YN7 25849887 Non-oxidized YfiR 2015-03-09 2015-04-22 Yang, X.,Yang, X.-A.,Xu, M.,Zhou, L.,Fan, Z.,Jiang, T. Crystal structures of YfiR from Pseudomonas aeruginosa in two redox states Biochem.Biophys.Res.Commun. 2015 461 14 20 4YN9 25849887 YfiR mutant-C110S 2015-03-09 2015-04-22 Yang, X.,Yang, X.-A.,Xu, M.,Zhou, L.,Fan, Z.,Jiang, T. Crystal structures of YfiR from Pseudomonas aeruginosa in two redox states Biochem.Biophys.Res.Commun. 2015 461 14 20 4PDX Crystal structure of Escherchia coli uncharacterized protein YjcS 2014-04-22 2015-04-29 Liang, Y.J.,Gao, Z.Q.,Dong, Y.H.,Liu, Q.S. Crystal structure of Escherchia coli uncharacterized protein YjcS To Be Published 0 0 0 0 4Q8B The crystal structure of CotA laccase complexed with sinapic acid 2014-04-26 2015-04-29 Xie, T.,Liu, Z.C.,Wang, G.G. The crystal structure of CotA laccase complexed with sinapic acid To be Published 0 0 0 0 4YZH 25888588 Structure of the Arabidopsis TAP38/PPH1 in complex with pLhcb1 phosphopeptide substrate 2015-03-25 2015-04-29 Wei, X.,Guo, J.,Li, M.,Liu, Z. Structural Mechanism Underlying the Specific Recognition between the Arabidopsis State-Transition Phosphatase TAP38/PPH1 and Phosphorylated Light-Harvesting Complex Protein Lhcb1 Plant Cell 2015 27 1113 1127 4R0T 25909591 Crystal structure of P. aeruginosa TpbA (C132S) in complex with pTyr 2014-08-01 2015-05-06 Xu, K.,Li, S.,Yang, W.,Li, K.,Bai, Y.,Xu, Y.,Jin, J.,Wang, Y.,Bartlam, M. Structural and Biochemical Analysis of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from the Opportunistic Pathogen Pseudomonas aeruginosa PAO1 Plos One 0 10 0 0 4QBR Crystal structure of DNMT3a ADD domain G550D mutant bound to H3 peptide 2014-05-08 2015-05-13 Noh, K.,Wang, H.,Kim, H.,Wenderski, W.,Fang, F.,Li, C.,Dewell, S.,Wu, X.,Ferris, A.,Hughes, S.H.,Zheng, D.,Melnick, A.M.,Patel, D.J.,Li, H.,Allis, C.D. Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs To be Published 0 0 0 0 4QBS Crystal structure of DNMT3a ADD domain E545R mutant bound to H3T3ph peptide 2014-05-08 2015-05-13 Noh, K.,Wang, H.,Kim, H.,Wenderski, W.,Fang, F.,Li, C.,Dewell, S.,Wu, X.,Ferris, A.,Hughes, S.H.,Zheng, D.,Melnick, A.M.,Patel, D.J.,Li, H.,Allis, C.D. Engineering of a histone-recognition domain in a de novo DNA methyltransferase alters the epigenetic landscape of ESCs To be Published 0 0 0 0 4RA2 PP2Ca 2014-09-09 2015-05-13 Pan, C.,Tang, J.Y.,Xu, Y.F.,Xiao, P.,Liu, H.D.,Wang, H.A.,Wang, W.B.,Meng, F.G.,Yu, X.,Sun, J.P. The catalytic role of the M2 metal ion in PP2Ca SCI REP 2015 0 0 0 4TMF 25226087 Crystal structure of human CD38 in complex with hydrolysed compound JMS713 2014-06-01 2015-05-13 Swarbrick, J.M.,Graeff, R.,Zhang, H.,Thomas, M.P.,Hao, Q.,Potter, B.V. Cyclic adenosine 5'-diphosphate ribose analogs without a ""southern"" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. J.Med.Chem. 2014 57 8517 8529 3X21 25917861 Crystal structure of Escherichia coli nitroreductase NfsB mutant T41L/N71S/F124W 2014-12-06 2015-05-20 Bai, J.,Zhou, Y.,Chen, Q.,Yang, Q.,Yang, J. Altering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineering. Chembiochem 2015 16 1219 1225 4OR9 Crystal structure of human calcineurin 2014-02-11 2015-05-20 Li, S.J.,Ma, L.,Wang, J.,Lu, C.,Wang, J.,Wu, J.W.,Wang, Z.X. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published 0 0 0 0 4ORA Crystal structure of a human calcineurin mutant 2014-02-11 2015-05-20 Li, S.J.,Ma, L.,Wang, J.,Lu, C.,Wang, J.,Wu, J.W.,Wang, Z.X. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published 0 0 0 0 4ORC Crystal structure of mammalian calcineurin 2014-02-11 2015-05-20 Li, S.J.,Ma, L.,Wang, J.,Lu, C.,Wang, J.,Wu, J.W.,Wang, Z.X. Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published 0 0 0 0 4ORO Structure of Influenza B PB2 cap-binding domain complex with GDP 2014-02-11 2015-05-20 Liu, Y.,Zheng, X. Structure of Influenza B PB2 cap-binding domain complex with GDP to be published 0 0 0 0 4QEI 26797133 Two distinct conformational states of GlyRS captured in crystal lattice 2014-05-16 2015-05-20 Deng, X.,Qin, X.,Chen, L.,Jia, Q.,Zhang, Y.,Zhang, Z.,Lei, D.,Ren, G.,Zhou, Z.,Wang, Z.,Li, Q.,Xie, W. Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis J.Biol.Chem. 2016 291 5740 5752 4RSL 25849495 Structure of fructosyl peptide oxidase from E. terrenum 2014-11-08 2015-05-20 Gan, W.,Gao, F.,Xing, K.,Jia, M.,Liu, H.,Gong, W. Structural basis of the substrate specificity of the FPOD/FAOD family revealed by fructosyl peptide oxidase from Eupenicillium terrenum Acta Crystallogr.,Sect.F 2015 71 381 387 4XFV 25960406 Crystal Structure of Elp2 2014-12-29 2015-05-20 Dong, C.,Lin, Z.,Diao, W.,Li, D.,Chu, X.,Wang, Z.,Zhou, H.,Xie, Z.,Shen, Y.,Long, J. The elp2 subunit is essential for elongator complex assembly and functional regulation Structure 2015 23 1078 1086 4XKB 25958236 Crystal Structure of GENOMES UNCOUPLED 4 (GUN4) in Complex with Deuteroporphyrin IX 2015-01-11 2015-05-20 Chen, X.,Pu, H.,Wang, X.,Long, W.,Lin, R.,Liu, L. Crystal Structures of GUN4 in Complex with Porphyrins. Mol Plant 2015 8 1125 1127 4XKC 25958236 Crystal Structure of GENOMES UNCOUPLED 4 (GUN4) in Complex with Magnesium Deuteroporphyrin IX 2015-01-11 2015-05-20 Chen, X.,Pu, H.,Wang, X.,Long, W.,Lin, R.,Liu, L. Crystal Structures of GUN4 in Complex with Porphyrins. Mol Plant 2015 8 1125 1127 4Z9P 25910597 Crystal structure of Ebola virus nucleoprotein core domain at 1.8A resolution 2015-04-11 2015-05-20 Dong, S.,Yang, P.,Li, G.,Liu, B.,Wang, W.,Liu, X.,Xia, B.,Yang, C.,Lou, Z.,Guo, Y.,Rao, Z. Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 A resolution. Protein Cell 2015 6 351 362 4QVC 25670676 E.coli Hfq in complex with RNA Aus 2014-07-14 2015-05-27 Wang, L.J.,Wang, W.W.,Li, F.D.,Zhang, J.,Wu, J.H.,Gong, Q.G.,Shi, Y.Y. Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq Nucleic Acids Res. 2015 43 2400 2411 4QVD 25670676 E.coli Hfq in complex with RNA Ads 2014-07-14 2015-05-27 Wang, L.J.,Wang, W.W.,Li, F.D.,Zhang, J.,Wu, J.H.,Gong, Q.G.,Shi, Y.Y. Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq Nucleic Acids Res. 2015 43 2400 2411 4R8X 25786739 Crystal structure of a uricase from Bacillus fastidious 2014-09-03 2015-05-27 Feng, J.,Wang, L.,Liu, H.,Yang, X.,Liu, L.,Xie, Y.,Liu, M.,Zhao, Y.,Li, X.,Wang, D.,Zhan, C.G.,Liao, F. Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditions. Appl.Microbiol.Biotechnol. 2015 99 7973 7986 4R99 25786739 Crystal structure of a uricase from Bacillus fastidious 2014-09-03 2015-05-27 Feng, J.,Wang, L.,Liu, H.,Yang, X.,Liu, L.,Xie, Y.,Liu, M.,Zhao, Y.,Li, X.,Wang, D.,Zhan, C.G.,Liao, F. Crystal structure of Bacillus fastidious uricase reveals an unexpected folding of the C-terminus residues crucial for thermostability under physiological conditions. Appl.Microbiol.Biotechnol. 2015 99 7973 7986 4X36 26057677 Crystal structure of the autolysin LytA from Streptococcus pneumoniae TIGR4 2014-11-28 2015-05-27 Li, Q.,Cheng, W.,Morlot, C.,Bai, X.H.,Jiang, Y.L.,Wang, W.,Roper, D.I.,Vernet, T.,Dong, Y.H.,Chen, Y.,Zhou, C.Z. Full-length structure of the major autolysin LytA. Acta Crystallogr.,Sect.D 2015 71 1373 1381 4YOC 25960197 Crystal Structure of human DNMT1 and USP7/HAUSP complex 2015-03-11 2015-05-27 Cheng, J.,Yang, H.,Fang, J.,Ma, L.,Gong, R.,Wang, P.,Li, Z.,Xu, Y. Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nat Commun 2015 6 7023 7023 4Y9L 25981666 Crystal Structure of Caenorhabditis elegans ACDH-11 2015-02-17 2015-06-03 Ma, D.K.,Li, Z.,Lu, A.Y.,Sun, F.,Chen, S.,Rothe, M.,Menzel, R.,Sun, F.,Horvitz, H.R. Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids Cell 2015 161 1152 1163 4YKC 25982527 Crystal structure of cerebral cavernous malformation 2 C-terminal adaptor domain 2015-03-04 2015-06-03 Wang, X.,Hou, Y.,Deng, K.,Zhang, Y.,Wang, D.C.,Ding, J. Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3 Structure 2015 23 1087 1096 4YKD 25982527 Crystal structure of truncated cerebral cavernous malformation 2 C-terminal adaptor domain 2015-03-04 2015-06-03 Wang, X.,Hou, Y.,Deng, K.,Zhang, Y.,Wang, D.C.,Ding, J. Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3 Structure 2015 23 1087 1096 3WVT 25559821 Structural and biochemical study of equine lentivirus receptor 1 2014-06-07 2015-06-10 Qian, L.,Han, X.D.,Liu, X.Q. Structural insight into equine lentivirus receptor 1 Protein Sci. 2015 24 633 642 3WX8 25195176 Purification, characterization and structure of nucleoside diphosphate kinase from Drosophila S2 cells 2014-07-25 2015-06-10 Qian, L.,Liu, X. Purification, characterization and structure of nucleoside diphosphate kinase from Drosophila melanogaster Protein Expr.Purif. 2014 103 48 55 4YVO 26037924 Crystal Structure of the TPR Domain of Arabidopsis FLU (FLU-TPR) 2015-03-20 2015-06-10 Zhang, M.,Zhang, F.,Fang, Y.,Chen, X.,Chen, Y.,Zhang, W.,Dai, H.E.,Lin, R.,Liu, L. The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase. J.Biol.Chem. 2015 290 17559 17565 4YVQ 26037924 Crystal Structure of FLU-TPR in Complex with the C-terminal Region of GluTR 2015-03-20 2015-06-10 Zhang, M.,Zhang, F.,Fang, Y.,Chen, X.,Chen, Y.,Zhang, W.,Dai, H.E.,Lin, R.,Liu, L. The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase. J.Biol.Chem. 2015 290 17559 17565 4W98 Acinetobacter baumannii SDF NDK 2014-08-27 2015-06-17 Hu, Y.,Feng, F.,Liu, Y. Structural and Functional Characterization of Acinetobacter baumannii Nucleoside Diphosphate Kinase Prog.Biochem.Biophys. 2015 42 260 267 4ZRI 26045165 Crystal structure of Merlin-FERM and Lats2 2015-05-12 2015-06-17 Li, Y.,Zhou, H.,Li, F.,Chan, S.W.,Lin, Z.,Wei, Z.,Yang, Z.,Guo, F.,Lim, C.J.,Xing, W.,Shen, Y.,Hong, W.,Long, J.,Zhang, M. Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res. 2015 25 801 817 4ZRI 26045165 Crystal structure of Merlin-FERM and Lats2 2015-05-12 2015-06-17 Li, Y.,Zhou, H.,Li, F.,Chan, S.W.,Lin, Z.,Wei, Z.,Yang, Z.,Guo, F.,Lim, C.J.,Xing, W.,Shen, Y.,Hong, W.,Long, J.,Zhang, M. Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res. 2015 25 801 817 4ZRK 26045165 Merlin-FERM and Lats1 complex 2015-05-12 2015-06-17 Li, Y.,Zhou, H.,Li, F.,Chan, S.W.,Lin, Z.,Wei, Z.,Yang, Z.,Guo, F.,Lim, C.J.,Xing, W.,Shen, Y.,Hong, W.,Long, J.,Zhang, M. Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res. 2015 25 801 817 4ZRK 26045165 Merlin-FERM and Lats1 complex 2015-05-12 2015-06-17 Li, Y.,Zhou, H.,Li, F.,Chan, S.W.,Lin, Z.,Wei, Z.,Yang, Z.,Guo, F.,Lim, C.J.,Xing, W.,Shen, Y.,Hong, W.,Long, J.,Zhang, M. Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway Cell Res. 2015 25 801 817 4ZSA 26080733 Crystal structure of FGFR1 kinase domain in complex with 7n 2015-05-13 2015-06-17 Liu, J.,Peng, X.,Dai, Y.,Zhang, W.,Ren, S.,Ai, J.,Geng, M.,Li, Y. Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold. Org.Biomol.Chem. 2015 13 7643 7654 4PMD Crystal structure of CbXyn10B from Caldicellulosiruptor bescii and its mutant(E139A) in complex with hydrolyzed xylotetraose 2014-05-21 2015-06-24 An, J.,Wu, G.,Feng, Y. Crystal structure of CbXyn10B from Caldicellulosiruptor bescii and its mutant(E139A) in complex with hydrolyzed xylotetraose to be published 0 0 0 0 4RVS 25924579 The native structure of mycobacterial quinone oxidoreductase Rv154c. 2014-11-27 2015-06-24 Zheng, Q.,Song, Y.,Zhang, W.,Shaw, N.,Zhou, W.,Rao, Z. Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor. Febs J. 2015 282 2697 2707 4RVU 25924579 The native structure of mycobacterial Rv1454c complexed with NADPH 2014-11-27 2015-06-24 Zheng, Q.,Song, Y.,Zhang, W.,Shaw, N.,Zhou, W.,Rao, Z. Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by the co-factor. Febs J. 2015 282 2697 2707 4XCH S-ribosylhomocysteinase from Streptococcus suis 2014-12-18 2015-06-24 Wang, Y.,Mao, X.,Lu, C. Crystal Structure of LuxS from Streptococcus suis To Be Published 0 0 0 0 4XZ7 26085092 Crystal structure of a TGase 2015-02-04 2015-06-24 Yu, J.,Pian, Y.,Ge, J.,Guo, J.,Zheng, Y.,Jiang, H.,Hao, H.,Yuan, Y.,Jiang, Y.,Yang, M. Functional and Structural Characterization of the Antiphagocytic Properties of a Novel Transglutaminase from Streptococcus suis J.Biol.Chem. 2015 290 19081 19092 3X0E 26116703 Crystal structure of the ectodomain of human CD81 large extracellular loop (hCD81-LEL) 2014-10-14 2015-07-01 Yang, W.,Zhang, M.,Chi, X.,Liu, X.,Qin, B.,Cui, S. An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry. Faseb J. 2015 29 4214 4226 4QR3 25559428 Brd4 Bromodomain 1 complex with its novel inhibitors 2014-06-30 2015-07-01 Zhao, L.,Wang, Y.,Cao, D.Y.,Chen, T.T.,Wang, Q.,Li, Y.,Xu, Y.C.,Zhang, N.,Wang, X.,Chen, D.,Chen, L.,Chen, Y.L.,Xia, G.,Shi, Z.,Liu, Y.C.,Lin, Y.,Miao, Z.,Shen, J.,Xiong, B. Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem. 2015 58 1281 1297 4QR4 25559428 Brd4 Bromodomain 1 complex with its novel inhibitors 2014-06-30 2015-07-01 Zhao, L.,Wang, Y.,Cao, D.Y.,Chen, T.T.,Wang, Q.,Li, Y.,Xu, Y.C.,Zhang, N.,Wang, X.,Chen, D.,Chen, L.,Chen, Y.L.,Xia, G.,Shi, Z.,Liu, Y.C.,Lin, Y.,Miao, Z.,Shen, J.,Xiong, B. Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem. 2015 58 1281 1297 4QR5 25559428 Brd4 Bromodomain 1 complex with its novel inhibitors 2014-06-30 2015-07-01 Zhao, L.,Wang, Y.,Cao, D.Y.,Chen, T.T.,Wang, Q.,Li, Y.,Xu, Y.C.,Zhang, N.,Wang, X.,Chen, D.,Chen, L.,Chen, Y.L.,Xia, G.,Shi, Z.,Liu, Y.C.,Lin, Y.,Miao, Z.,Shen, J.,Xiong, B. Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization J.Med.Chem. 2015 58 1281 1297 4RR5 25582772 The crystal structure of Synechocystis sp. PCC 6803 Malonyl-CoA: ACP Transacylase 2014-11-06 2015-07-01 Liu, Y.,Feng, Y.,Wang, Y.,Li, X.,Cao, X.,Xue, S. Structural and biochemical characterization of MCAT from photosynthetic microorganism Synechocystis sp. PCC 6803 reveal its stepwise catalytic mechanism Biochem.Biophys.Res.Commun. 2015 457 398 403 4WY8 26108223 Structural analysis of two fungal esterases from Rhizomucor miehei explaining their substrate specificity 2014-11-16 2015-07-01 Yang, S.,Qin, Z.,Duan, X.,Yan, Q.,Jiang, Z. Structural insights into the substrate specificity of two esterases from the thermophilic Rhizomucor miehei J.Lipid Res. 2015 56 1616 1624 4XGY 26144238 GFP based antibody (fluorobody) 2015-01-03 2015-07-01 Chen, Y.,Huang, X.,Wang, R.,Wang, S.,Shi, N. The structure of a GFP-based antibody (fluorobody) to TLH, a toxin from Vibrio parahaemolyticus. Acta Crystallogr.,Sect.F 2015 71 913 918 4XHR 26071601 Structure of a phospholipid trafficking complex, native 2015-01-06 2015-07-01 Yu, F.,He, F.,Yao, H.,Wang, C.,Wang, J.,Li, J.,Qi, X.,Xue, H.,Ding, J.,Zhang, P. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex Embo Rep. 2015 16 813 823 4XIZ 26071601 Structure of a phospholipid trafficking complex with substrate 2015-01-08 2015-07-01 Yu, F.,He, F.,Yao, H.,Wang, C.,Wang, J.,Li, J.,Qi, X.,Xue, H.,Ding, J.,Zhang, P. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex Embo Rep. 2015 16 813 823 4YRH p21 isoform of MEC-17 from Danio Rerio 2015-03-15 2015-07-01 Xue, T. Structure of DrMEC-17 residue 2-185 at 2.85 Angstroms resolution To Be Published 0 0 0 0 5BTR 26109052 Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide 2015-06-03 2015-07-08 Cao, D.,Wang, M.,Qiu, X.,Liu, D.,Jiang, H.,Yang, N.,Xu, R.M. Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol Genes Dev. 2015 29 1316 1325 5C56 26210801 Crystal structure of USP7/HAUSP in complex with ICP0 2015-06-19 2015-07-08 Cheng, J.,Li, Z.,Gong, R.,Fang, J.,Yang, Y.,Sun, C.,Yang, H.,Xu, Y. Molecular mechanism for the substrate recognition of USP7. Protein Cell 2015 6 849 852 3WZG 26106927 Crystal structure of AfCsx3 2014-09-25 2015-07-15 Yan, X.,Guo, W.,Yuan, Y.A. Crystal structures of CRISPR-associated Csx3 reveal a manganese-dependent deadenylation exoribonuclease. Rna Biol. 2015 12 749 760 4QLZ The structure of inorganic pyrophosphatase from Schistosoma japonicum 2014-06-13 2015-07-15 Wu, Q.F. Study on the structure and function of inorganic pyrophosphatase from Schistosoma japonicum To be Published 0 0 0 0 4QMB The structure of inorganic pyrophosphatase from Schistosoma japonicum 2014-06-15 2015-07-15 Wu, Q.F. The structure and function of inorganic pyrophosphatase from Schistosoma japonicum To be Published 0 0 0 0 4RAY 26134419 Crystal structure of Magnetospirillum gryphiswaldense MSR-1 Apo-Fur 2014-09-12 2015-07-15 Deng, Z.,Wang, Q.,Liu, Z.,Zhang, M.,Machado, A.C.,Chiu, T.P.,Feng, C.,Zhang, Q.,Yu, L.,Qi, L.,Zheng, J.,Wang, X.,Huo, X.,Qi, X.,Li, X.,Wu, W.,Rohs, R.,Li, Y.,Chen, Z. Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nat Commun 0 6 7642 7642 4RAZ 26134419 Crystal structure of Magnetospirillum gryphiswaldense MSR-1 holo-Fur 2014-09-12 2015-07-15 Deng, Z.,Wang, Q.,Liu, Z.,Zhang, M.,Machado, A.C.,Chiu, T.P.,Feng, C.,Zhang, Q.,Yu, L.,Qi, L.,Zheng, J.,Wang, X.,Huo, X.,Qi, X.,Li, X.,Wu, W.,Rohs, R.,Li, Y.,Chen, Z. Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nat Commun 0 6 7642 7642 4XBX 25891639 Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH 2014-12-17 2015-07-15 Sun, Z.,Lonsdale, R.,Kong, X.D.,Xu, J.H.,Zhou, J.,Reetz, M.T. Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl. 2015 54 12410 12415 4XH3 25959226 Mechanistic insights into anchorage of the contractile ring from yeast to humans 2015-01-04 2015-07-15 Sun, L.,Guan, R.,Lee, I.J.,Liu, Y.,Chen, M.,Wang, J.,Wu, J.Q.,Chen, Z. Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell 2015 33 413 426 4XOH 25959226 Mechanistic insights into anchorage of the contractile ring from yeast to humans 2015-01-16 2015-07-15 Sun, L.,Guan, R.,Lee, I.J.,Liu, Y.,Chen, M.,Wang, J.,Wu, J.Q.,Chen, Z. Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell 2015 33 413 426 4XOI 25959226 Structure of hsAnillin bound with RhoA(Q63L) at 2.1 Angstroms resolution 2015-01-16 2015-07-15 Sun, L.,Guan, R.,Lee, I.J.,Liu, Y.,Chen, M.,Wang, J.,Wu, J.Q.,Chen, Z. Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell 2015 33 413 426 4XPJ 26144237 Crystal structure of Nerve growth factor in complex with lysophosphatidylinositol 2015-01-17 2015-07-15 Sun, H.L.,Jiang, T. The structure of nerve growth factor in complex with lysophosphatidylinositol Acta Crystallogr.,Sect.F 2015 71 906 912 4ZZH 26134520 SIRT1/Activator Complex 2015-05-22 2015-07-15 Dai, H.,Case, A.W.,Riera, T.V.,Considine, T.,Lee, J.E.,Hamuro, Y.,Zhao, H.,Jiang, Y.,Sweitzer, S.M.,Pietrak, B.,Schwartz, B.,Blum, C.A.,Disch, J.S.,Caldwell, R.,Szczepankiewicz, B.,Oalmann, C.,Yee Ng, P.,White, B.H.,Casaubon, R.,Narayan, R.,Koppetsch, K.,Bourbonais, F.,Wu, B.,Wang, J.,Qian, D.,Jiang, F.,Mao, C.,Wang, M.,Hu, E.,Wu, J.C.,Perni, R.B.,Vlasuk, G.P.,Ellis, J.L. Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Nat Commun 2015 6 7645 7645 5C8S 26159422 Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligands SAH and GpppA 2015-06-26 2015-07-15 Ma, Y.Y.,Wu, L.J.,Shaw, N.,Gao, Y.,Wang, J.,Sun, Y.N.,Lou, Z.Y.,Yan, L.M.,Zhang, R.G.,Rao, Z.H. Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex Proc.Natl.Acad.Sci.USA 2015 112 9436 9441 5C8T 26159422 Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM 2015-06-26 2015-07-15 Ma, Y.Y.,Wu, L.J.,Shaw, N.,Gao, Y.,Wang, J.,Sun, Y.N.,Lou, Z.Y.,Yan, L.M.,Zhang, R.G.,Rao, Z.H. Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex Proc.Natl.Acad.Sci.USA 2015 112 9436 9441 5C8U 26159422 Crystal structure of the SARS coronavirus nsp14-nsp10 complex 2015-06-26 2015-07-15 Ma, Y.Y.,Wu, L.J.,Shaw, N.,Gao, Y.,Wang, J.,Sun, Y.N.,Lou, Z.Y.,Yan, L.M.,Zhang, R.G.,Rao, Z.H. Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex Proc.Natl.Acad.Sci.USA 2015 112 9436 9441 4PL6 25211338 Structure of the chromodomain of MRG2 in complex with H3K4me3 2014-05-16 2015-07-22 Bu, Z.,Yu, Y.,Li, Z.,Liu, Y.,Jiang, W.,Huang, Y.,Dong, A.W. Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. Plos Genet. 2014 10 0 0 4PLI 25211338 Structure of the chromodomain of MRG2 in complex with H3K36me3 2014-05-18 2015-07-22 Bu, Z.,Yu, Y.,Li, Z.,Liu, Y.,Jiang, W.,Huang, Y.,Dong, A.W. Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. Plos Genet. 2014 10 0 0 4PLL 25211338 Structure of the chromodaomain of MRG2 in complex with H3K36me3 2014-05-18 2015-07-22 Bu, Z.,Yu, Y.,Li, Z.,Liu, Y.,Jiang, W.,Huang, Y.,Dong, A.W. Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. Plos Genet. 2014 10 0 0 4QWP 26145578 co-crystal structure of chitosanase OU01 with substrate 2014-07-17 2015-07-22 Lyu, Q.,Shi, Y.,Wang, S.,Yang, Y.,Han, B.,Liu, W.,Jones, D.N.,Liu, W. Structural and biochemical insights into the degradation mechanism of chitosan by chitosanase OU01. Biochim.Biophys.Acta 2015 1850 1953 1961 4Z7F 26198469 Crystal structure of FolT bound with folic acid 2015-04-07 2015-07-29 Zhao, Q.,Wang, C.C.,Wang, C.Y.,Guo, H.,Bao, Z.H.,Zhang, M.H.,Zhang, P. Structures of FolT in substrate-bound and substrate-released conformations reveal a gating mechanism for ECF transporters Nat Commun 2015 6 7661 7661 5C3I 26186914 Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2 2015-06-17 2015-07-29 Wang, H.,Wang, M.,Yang, N.,Xu, R.M. Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2 Protein Cell 2015 6 693 697 4RZY 26154071 Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP in complex with MES 2014-12-26 2015-08-05 Wang, P.,Chen, X.L.,Li, C.Y.,Gao, X.,Zhu, D.Y.,Xie, B.B.,Qin, Q.L.,Zhang, X.Y.,Su, H.N.,Zhou, B.C.,Xun, L.Y.,Zhang, Y.Z. Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold. Mol.Microbiol. 2015 98 289 301 4RZZ 26154071 Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP in complex with phosphate 2014-12-27 2015-08-05 Wang, P.,Chen, X.L.,Li, C.Y.,Gao, X.,Zhu, D.Y.,Xie, B.B.,Qin, Q.L.,Zhang, X.Y.,Su, H.N.,Zhou, B.C.,Xun, L.Y.,Zhang, Y.Z. Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold. Mol.Microbiol. 2015 98 289 301 4S00 26154071 Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP mutant Y366A in complex with acrylate 2014-12-27 2015-08-05 Wang, P.,Chen, X.L.,Li, C.Y.,Gao, X.,Zhu, D.Y.,Xie, B.B.,Qin, Q.L.,Zhang, X.Y.,Su, H.N.,Zhou, B.C.,Xun, L.Y.,Zhang, Y.Z. Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold. Mol.Microbiol. 2015 98 289 301 4S01 26154071 Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP mutant D377N in complex with acrylate 2014-12-27 2015-08-05 Wang, P.,Chen, X.L.,Li, C.Y.,Gao, X.,Zhu, D.Y.,Xie, B.B.,Qin, Q.L.,Zhang, X.Y.,Su, H.N.,Zhou, B.C.,Xun, L.Y.,Zhang, Y.Z. Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold. Mol.Microbiol. 2015 98 289 301 4U68 25613572 Crystal structure of Rhino chromodomain in complex with H3K9me3 2014-07-28 2015-08-05 Yu, B.W.,Cassani, M.,Wang, M.,Liu, M.,Ma, J.,Li, G.,Zhang, Z.,Huang, Y. Structural insights into Rhino-mediated germline piRNA cluster formation Cell Res. 2015 25 525 528 4XPM 26206314 Crystal structure of EGO-TC 2015-01-17 2015-08-05 Powis, K.,Zhang, T.,Panchaud, N.,Wang, R.,De Virgilio, C.,Ding, J. Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling. Cell Res. 2015 25 1043 1059 4XPM 26206314 Crystal structure of EGO-TC 2015-01-17 2015-08-05 Powis, K.,Zhang, T.,Panchaud, N.,Wang, R.,De Virgilio, C.,Ding, J. Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling. Cell Res. 2015 25 1043 1059 5CP3 30580515 Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides in Complex with Sulfathiazole 2015-07-21 2015-08-05 Li, C.,Liang, X.,Wen, K.,Li, Y.,Zhang, X.,Ma, M.,Yu, X.,Yu, W.,Shen, J.,Wang, Z. Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity. Anal. Chem. 2019 91 2392 2400 5CP7 30580515 Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides 2015-07-21 2015-08-05 Li, C.,Liang, X.,Wen, K.,Li, Y.,Zhang, X.,Ma, M.,Yu, X.,Yu, W.,Shen, J.,Wang, Z. Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity. Anal. Chem. 2019 91 2392 2400 4R77 25781969 Crystal structure of choline kinase LicA from Streptococcus pneumoniae 2014-08-27 2015-08-12 Wang, L.,Jiang, Y.L.,Zhang, J.R.,Zhou, C.Z.,Chen, Y.X. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae Plos One 2015 10 0 0 4R78 25781969 Crystal structure of LicA in complex with AMP 2014-08-27 2015-08-12 Wang, L.,Jiang, Y.L.,Zhang, J.R.,Zhou, C.Z.,Chen, Y.X. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae Plos One 2015 10 0 0 4R7B 25781969 Crystal structure of pneumococcal LicA in complex with choline 2014-08-27 2015-08-12 Wang, L.,Jiang, Y.L.,Zhang, J.R.,Zhou, C.Z.,Chen, Y.X. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae Plos One 2015 10 0 0 4WTP 26249352 Crystal structure of glycoside hydrolase family 17 beta-1,3-glucanosyltransferase from Rhizomucor miehei 2014-10-30 2015-08-12 Qin, Z.,Yan, Q.,Lei, J.,Yang, S.,Jiang, Z.,Wu, S. The first crystal structure of a glycoside hydrolase family 17 beta-1,3-glucanosyltransferase displays a unique catalytic cleft. Acta Crystallogr.,Sect.D 2015 71 1714 1724 4XT9 26277758 RORgamma (263-509) complexed with GSK2435341A and SRC2 2015-01-23 2015-08-12 Wang, Y.,Yang, T.,Liu, Q.,Ma, Y.,Yang, L.,Zhou, L.,Xiang, Z.,Cheng, Z.,Lu, S.,Orband-Miller, L.A.,Zhang, W.,Wu, Q.,Zhang, K.,Li, Y.,Xiang, J.N.,Elliott, J.D.,Leung, S.,Ren, F.,Lin, X. Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists Bioorg.Med.Chem. 2015 23 5293 5302 4YTK 26217010 Structure of the KOW1-Linker1 domain of Transcription Elongation Factor Spt5 2015-03-17 2015-08-12 Meyer, P.A.,Li, S.,Zhang, M.,Yamada, K.,Takagi, Y.,Hartzog, G.A.,Fu, J. Structures and Functions of the Multiple KOW Domains of Transcription Elongation Factor Spt5. Mol.Cell.Biol. 2015 35 3354 3369 4YTL 26217010 Structure of the KOW2-KOW3 Domain of Transcription Elongation Factor Spt5. 2015-03-17 2015-08-12 Meyer, P.A.,Li, S.,Zhang, M.,Yamada, K.,Takagi, Y.,Hartzog, G.A.,Fu, J. Structures and Functions of the Multiple KOW Domains of Transcription Elongation Factor Spt5. Mol.Cell.Biol. 2015 35 3354 3369 4XZ6 26283766 TmoX in complex with TMAO 2015-02-04 2015-08-19 Li, C.Y.,Chen, X.L.,Shao, X.,Wei, T.D.,Wang, P.,Xie, B.B.,Qin, Q.L.,Zhang, X.Y.,Su, H.N.,Song, X.Y.,Shi, M.,Zhou, B.C.,Zhang, Y.Z. Mechanistic Insight into Trimethylamine N-Oxide Recognition by the Marine Bacterium Ruegeria pomeroyi DSS-3 J.Bacteriol. 2015 197 3378 3387 4ZA1 26244829 Crystal Structure of NosA Involved in Nosiheptide Biosynthesis 2015-04-13 2015-08-19 Liu, S.,Guo, H.,Zhang, T.,Han, L.,Yao, P.,Zhang, Y.,Rong, N.,Yu, Y.,Lan, W.,Wang, C.,Ding, J.,Wang, R.,Liu, W.,Cao, C. Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis Sci Rep 2015 5 12744 12744 4ZP0 26238402 Crystal structure of E. coli multidrug transporter MdfA in complex with deoxycholate 2015-05-07 2015-08-19 Heng, J.,Zhao, Y.,Liu, M.,Liu, Y.,Fan, J.,Wang, X.,Zhao, Y.,Zhang, X.C. Substrate-bound structure of the E. coli multidrug resistance transporter MdfA Cell Res. 2015 25 1060 1073 4ZP2 26238402 Crystal structure of E. coli multidrug transporter MdfA in complex with n-dodecyl-N,N-dimethylamine-N-oxide 2015-05-07 2015-08-19 Heng, J.,Zhao, Y.,Liu, M.,Liu, Y.,Fan, J.,Wang, X.,Zhao, Y.,Zhang, X.C. Substrate-bound structure of the E. coli multidrug resistance transporter MdfA Cell Res. 2015 25 1060 1073 5CQR 26261306 Dimerization of Elp1 is essential for Elongator complex assembly 2015-07-22 2015-08-19 Xu, H.,Lin, Z.,Li, F.,Diao, W.,Dong, C.,Zhou, H.,Xie, X.,Wang, Z.,Shen, Y.,Long, J. Dimerization of elongator protein 1 is essential for Elongator complex assembly. Proc.Natl.Acad.Sci.USA 2015 112 10697 10702 4R8W 26196962 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a neutralizing antibody CT149 2014-09-03 2015-08-26 Wu, Y.,Cho, M.,Shore, D.,Song, M.,Choi, J.,Jiang, T.,Deng, Y.Q.,Bourgeois, M.,Almli, L.,Yang, H.,Chen, L.M.,Shi, Y.,Qi, J.,Li, A.,Yi, K.S.,Chang, M.,Bae, J.S.,Lee, H.,Shin, J.,Stevens, J.,Hong, S.,Qin, C.F.,Gao, G.F.,Chang, S.J.,Donis, R.O. A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus Nat Commun 2015 6 7708 7708 4RAF 25708299 Crystal structure of PP2Ca-D38A 2014-09-10 2015-08-26 Pan, C.,Tang, J.Y.,Xu, Y.F.,Xiao, P.,Liu, H.D.,Wang, H.A.,Wang, W.B.,Meng, F.G.,Yu, X.,Sun, J.P. The catalytic role of the M2 metal ion in PP2C alpha Sci Rep 2015 5 8560 8560 4RAG 25708299 CRYSTAL STRUCTURE of PPC2A-D38K 2014-09-10 2015-08-26 Pan, C.,Tang, J.Y.,Xu, Y.F.,Xiao, P.,Liu, H.D.,Wang, H.A.,Wang, W.B.,Meng, F.G.,Yu, X.,Sun, J.P. The catalytic role of the M2 metal ion in PP2C alpha Sci Rep 2015 5 8560 8560 4Y7K 26261325 Structure of an archaeal mechanosensitive channel in closed state 2015-02-15 2015-08-26 Li, J.,Guo, J.,Ou, X.,Zhang, M.,Li, Y.,Liu, Z. Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion Proc.Natl.Acad.Sci.USA 2015 112 10726 10731 4ZHJ 27250678 Crystal Structure of the Catalytic Subunit of Magnesium Chelatase 2015-04-25 2015-08-26 Chen, X.,Pu, H.,Fang, Y.,Wang, X.,Zhao, S.,Lin, Y.,Zhang, M.,Dai, H.E.,Gong, W.,Liu, L. Crystal structure of the catalytic subunit of magnesium chelatase Nat.Plants 2015 1 15125 15125 5BUQ 26276389 Unliganded Form of O-succinylbenzoate Coenzyme A Synthetase (MenE) from Bacillus Subtilis, Solved at 1.98 Angstroms 2015-06-04 2015-08-26 Chen, Y.,Sun, Y.,Song, H.,Guo, Z. Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase J.Biol.Chem. 2015 290 23971 23983 5BUR 26276389 O-succinylbenzoate Coenzyme A Synthetase (MenE) from Bacillus Subtilis, in Complex with ATP and Magnesium Ion 2015-06-04 2015-08-26 Chen, Y.,Sun, Y.,Song, H.,Guo, Z. Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase J.Biol.Chem. 2015 290 23971 23983 5BUS 26276389 O-succinylbenzoate Coenzyme A Synthetase (MenE) from Bacillus Subtilis, in complex with AMP 2015-06-04 2015-08-26 Chen, Y.,Sun, Y.,Song, H.,Guo, Z. Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase J.Biol.Chem. 2015 290 23971 23983 4R6M Crystal Structure of DNA Duplex Containing Two Consecutive Mercury-mediated Base Pairs 2014-08-26 2015-09-02 Xu, C.Y.,Yu, F.,Wang, L.H.,Zhao, Y.,Lin, T.,Fan, C.H.,He, J.H. Crystal Structure of DNA Duplex Containing Two Consecutive Mercury-mediated Base Pairs To be Published 0 0 0 0 4U7N 28994408 Inactive structure of histidine kinase 2014-07-31 2015-09-02 Cai, Y.,Su, M.,Ahmad, A.,Hu, X.,Sang, J.,Kong, L.,Chen, X.,Wang, C.,Shuai, J.,Han, A. Conformational dynamics of the essential sensor histidine kinase WalK. Acta Crystallogr D Struct Biol 2017 73 793 803 4U7O 28994408 Active histidine kinase bound with ATP 2014-07-31 2015-09-02 Cai, Y.,Su, M.,Ahmad, A.,Hu, X.,Sang, J.,Kong, L.,Chen, X.,Wang, C.,Shuai, J.,Han, A. Conformational dynamics of the essential sensor histidine kinase WalK. Acta Crystallogr D Struct Biol 2017 73 793 803 4ZS6 26281793 Receptor binding domain and Fab complex 2015-05-13 2015-09-02 Yu, X.,Zhang, S.,Jiang, L.,Cui, Y.,Li, D.,Wang, D.,Wang, N.,Fu, L.,Shi, X.,Li, Z.,Zhang, L.,Wang, X. Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 Sci Rep 2015 5 13133 13133 4ZXA 26304122 Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Cd2+ and 4-hydroxybenzonitrile 2015-05-20 2015-09-02 Liu, S.,Su, T.,Zhang, C.,Zhang, W.M.,Zhu, D.,Su, J.,Wei, T.,Wang, K.,Huang, Y.,Guo, L.,Xu, S.,Zhou, N.Y.,Gu, L. Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases. J.Biol.Chem. 2015 290 24547 24560 4ZXC 26304122 Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Fe3+ 2015-05-20 2015-09-02 Liu, S.,Su, T.,Zhang, C.,Zhang, W.M.,Zhu, D.,Su, J.,Wei, T.,Wang, K.,Huang, Y.,Guo, L.,Xu, S.,Zhou, N.Y.,Gu, L. Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases. J.Biol.Chem. 2015 290 24547 24560 4ZXD 26304122 Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD 2015-05-20 2015-09-02 Liu, S.,Su, T.,Zhang, C.,Zhang, W.M.,Zhu, D.,Su, J.,Wei, T.,Wang, K.,Huang, Y.,Guo, L.,Xu, S.,Zhou, N.Y.,Gu, L. Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases. J.Biol.Chem. 2015 290 24547 24560 5BRR 26324706 Michaelis complex of tPA-S195A:PAI-1 2015-06-01 2015-09-02 Gong, L.,Liu, M.,Zeng, T.,Shi, X.,Yuan, C.,Andreasen, P.A.,Huang, M. Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1 J.Biol.Chem. 2015 290 25795 25804 5CCU 28179425 Crystal structure of endoglycoceramidase I from Rhodococ-cus equi 2015-07-02 2015-09-02 Han, Y.B.,Chen, L.Q.,Li, Z.,Tan, Y.M.,Feng, Y.,Yang, G.Y. Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases J. Biol. Chem. 2017 292 4789 4800 5CD7 26324911 Crystal structure of the NTD L199M of Drosophila Oskar protein 2015-07-03 2015-09-02 Yang, N.,Yu, Z.,Hu, M.,Wang, M.,Lehmann, R.,Xu, R.M. Structure of Drosophila Oskar reveals a novel RNA binding protein Proc.Natl.Acad.Sci.USA 2015 112 11541 11546 5CD8 26324911 Crystal structure of the NTD of Drosophila Oskar protein 2015-07-03 2015-09-02 Yang, N.,Yu, Z.,Hu, M.,Wang, M.,Lehmann, R.,Xu, R.M. Structure of Drosophila Oskar reveals a novel RNA binding protein Proc.Natl.Acad.Sci.USA 2015 112 11541 11546 5CD9 26324911 Crystal structure of the CTD of Drosophila Oskar protein 2015-07-03 2015-09-02 Yang, N.,Yu, Z.,Hu, M.,Wang, M.,Lehmann, R.,Xu, R.M. Structure of Drosophila Oskar reveals a novel RNA binding protein Proc.Natl.Acad.Sci.USA 2015 112 11541 11546 4R9I 26148664 Crystal structure of cysteine proteinase inhibitor Serpin18 from Bombyx mori 2014-09-05 2015-09-09 Guo, P.C.,Dong, Z.,Zhao, P.,Zhang, Y.,He, H.W.,Tan, X.,Zhang, W.,Xia, Q.Y. Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18 Sci Rep 2015 5 11863 11863 4RE8 26235054 Crystal Structure of TR3 LBD in complex with Molecule 5 2014-09-22 2015-09-09 Wang, W.J.,Wang, Y.,Hou, P.P.,Li, F.W.,Zhou, B.,Chen, H.Z.,Bian, X.L.,Cai, Q.X.,Xing, Y.Z.,He, J.P.,Zhang, H.,Huang, P.Q.,Lin, T.,Wu, Q. Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity Chem.Biol. 2015 22 1040 1051 4WHF 26235054 Crystal Structure of TR3 LBD in complex with 1-(3,4,5-trihydroxyphenyl)decan-1-one 2014-09-22 2015-09-09 Wang, W.J.,Wang, Y.,Hou, P.P.,Li, F.W.,Zhou, B.,Chen, H.Z.,Bian, X.L.,Cai, Q.X.,Xing, Y.Z.,He, J.P.,Zhang, H.,Huang, P.Q.,Lin, T.,Wu, Q. Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity Chem.Biol. 2015 22 1040 1051 4WHG 26235054 Crystal Structure of TR3 LBD in complex with Molecule 3 2014-09-22 2015-09-09 Wang, W.J.,Wang, Y.,Hou, P.P.,Li, F.W.,Zhou, B.,Chen, H.Z.,Bian, X.L.,Cai, Q.X.,Xing, Y.Z.,He, J.P.,Zhang, H.,Huang, P.Q.,Lin, T.,Wu, Q. Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity Chem.Biol. 2015 22 1040 1051 4Y29 26183621 Identification of a novel PPARg ligand that regulates metabolism 2015-02-09 2015-09-09 Zheng, W.L.,Qiu, L.,Wang, R.,Feng, X.H.,Han, Y.P.,Zhu, Y.L.,Chen, D.Z.,Liu, Y.J.,Jin, L.H.,Li, Y. Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency. Sci Rep 2015 5 12222 12222 4ZB3 26253775 Crystal structure of the apo AtNUDT7 2015-04-14 2015-09-09 Tang, Q.,Liu, C.,Zhong, C.,Ding, J. Crystal Structures of Arabidopsis thaliana Nudix Hydrolase NUDT7 Reveal a Previously Unobserved Conformation. Mol Plant 2015 8 1557 1559 4ZBP 26253775 Crystal structure of the AMPCPR-bound AtNUDT7 2015-04-15 2015-09-09 Tang, Q.,Liu, C.,Zhong, C.,Ding, J. Crystal Structures of Arabidopsis thaliana Nudix Hydrolase NUDT7 Reveal a Previously Unobserved Conformation. Mol Plant 2015 8 1557 1559 4ZDR 26323294 Crystal structure of 14-3-3[zeta]-LKB1 fusion protein 2015-04-18 2015-09-09 Ding, S.,Zhou, R.,Zhu, Y. Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F 2015 71 1114 1119 5CCL 26985287 Crystal structure of SMYD3 with SAM and oxindole compound 2015-07-02 2015-09-09 Mitchell, L.H.,Boriack-Sjodin, P.A.,Smith, S.,Thomenius, M.,Rioux, N.,Munchhof, M.,Mills, J.E.,Klaus, C.,Totman, J.,Riera, T.V.,Raimondi, A.,Jacques, S.L.,West, K.,Foley, M.,Waters, N.J.,Kuntz, K.W.,Wigle, T.J.,Scott, M.P.,Copeland, R.A.,Smith, J.J.,Chesworth, R. Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. Acs Med.Chem.Lett. 2016 7 134 138 5CH9 Gkap mutant B12 2015-07-10 2015-09-09 Chen, L.-Q. Active site loop architecture enhance the promiscuous PTE activity in lactonase from Geobacillus kaustophilus HTA426 To Be Published 0 0 0 0 5D1I 26549229 Structure of Cyclic nucleotide-binding-like protein from Brucella abortus bv. 1 str. 9-941 2015-08-04 2015-09-09 He, Z.,Gao, Y.,Dong, J.,Ke, Y.,Li, X.,Chen, Z.,Zhang, X.C. Crystal structure of cyclic nucleotide-binding-like protein from Brucella abortus Biochem.Biophys.Res.Commun. 2015 468 647 652 4RGY 26350078 Structural and functional analysis of a low-temperature-active alkaline esterase from South China Sea marine sediment microbial metagenomic library 2014-10-01 2015-09-16 Hu, Y.,Liu, Y.,Li, J.,Feng, Y.,Lu, N.,Zhu, B.,Xue, S. Structural and functional analysis of a low-temperature-active alkaline esterase from South China Sea marine sediment microbial metagenomic library. J Ind Microbiol Biotechnol 2015 42 1449 1461 4RZH 26358291 Crystal structure of FabG from Synechocystis sp. PCC 6803 2014-12-22 2015-09-16 Liu, Y.,Feng, Y.,Cao, X.,Li, X.,Xue, S. Structure-directed construction of a high-performance version of the enzyme FabG from the photosynthetic microorganism Synechocystis sp. PCC 6803. Febs Lett. 2015 589 3052 3057 4ZHL 26281711 The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4 2015-04-25 2015-09-16 Srensen, H.P.,Xu, P.,Jiang, L.,Kromann-Hansen, T.,Jensen, K.J.,Huang, M.,Andreasen, P.A. Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions. J.Mol.Biol. 2015 427 3110 3122 4ZHM 26281711 The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4 2015-04-25 2015-09-16 Srensen, H.P.,Xu, P.,Jiang, L.,Kromann-Hansen, T.,Jensen, K.J.,Huang, M.,Andreasen, P.A. Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions. J.Mol.Biol. 2015 427 3110 3122 5CMZ 26286358 Artificial HIV fusion inhibitor AP3 fused to the C-terminus of gp41 NHR 2015-07-17 2015-09-16 Zhu, X.,Zhu, Y.,Ye, S.,Wang, Q.,Xu, W.,Su, S.,Sun, Z.,Yu, F.,Liu, Q.,Wang, C.,Zhang, T.,Zhang, Z.,Zhang, X.,Xu, J.,Du, L.,Liu, K.,Lu, L.,Zhang, R.,Jiang, S. Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy. Sci Rep 2015 5 13028 13028 4RAX 26390154 A regulatory domain of an ion channel 2014-09-11 2015-09-23 Ge, J.,Li, W.,Zhao, Q.,Li, N.,Chen, M.,Zhi, P.,Li, R.,Gao, N.,Xiao, B.,Yang, M. Architecture of the mammalian mechanosensitive Piezo1 channel. Nature 2015 527 64 69 4REY 26363069 Crystal Structure of the GRASP65-GM130 C-terminal peptide complex 2014-09-24 2015-09-23 Hu, F.,Shi, X.,Li, B.,Huang, X.,Morelli, X.,Shi, N. Structural Basis for the Interaction between the Golgi Reassembly-stacking Protein GRASP65 and the Golgi Matrix Protein GM130. J.Biol.Chem. 2015 290 26373 26382 4WXM 26362077 FleQ REC domain from Pseudomonas aeruginosa PAO1 2014-11-14 2015-09-23 Su, T.,Liu, S.,Wang, K.,Chi, K.,Zhu, D.,Wei, T.,Huang, Y.,Guo, L.,Hu, W.,Xu, S.,Lin, Z.,Gu, L. The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator J.Struct.Biol. 2015 192 1 13 4Z8M 26385923 Crystal structure of the MAVS-TRAF6 complex 2015-04-09 2015-09-23 Shi, Z.,Zhang, Z.,Zhang, Z.,Wang, Y.,Li, C.,Wang, X.,He, F.,Sun, L.,Jiao, S.,Shi, W.,Zhou, Z. Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling J.Biol.Chem. 2015 290 26811 26820 4ZDS 26352699 Crystal Structure of core DNA binding domain of Arabidopsis Thaliana Transcription Factor Ethylene-Insensitive 3 2015-04-18 2015-09-23 Song, J.,Zhu, C.,Zhang, X.,Wen, X.,Liu, L.,Peng, J.,Guo, H.,Yi, C. Biochemical and Structural Insights into the Mechanism of DNA Recognition by Arabidopsis ETHYLENE INSENSITIVE3. Plos One 2015 10 0 0 4ZRD 26365206 Crystal structure of SMG1 F278N mutant 2015-05-12 2015-09-23 Guo, S.,Xu, J.,Pavlidis, I.V.,Lan, D.,Bornscheuer, U.T.,Liu, J.,Wang, Y. Structure of product-bound SMG1 lipase: active site gating implications. Febs J. 2015 282 4538 4547 5CA9 26370501 Structures of the candida albicans sey1p GTPase in complex with GDPAlF4- 2015-06-29 2015-09-23 Yan, L.,Sun, S.,Wang, W.,Shi, J.,Hu, X.,Wang, S.,Su, D.,Rao, Z.,Hu, J.,Lou, Z. Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion J.Cell Biol. 2015 210 961 972 5CB2 26370501 the structure of candida albicans Sey1p in complex with GMPPNP 2015-06-30 2015-09-23 Yan, L.,Sun, S.,Wang, W.,Shi, J.,Hu, X.,Wang, S.,Su, D.,Rao, Z.,Hu, J.,Lou, Z. Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion J.Cell Biol. 2015 210 961 972 5CF3 26349459 Crystal structures of Bbp from Staphylococcus aureus 2015-07-08 2015-09-23 Zhang, X.Y.,Wu, M.,Zhuo, W.,Gu, J.K.,Zhang, S.S.,Ge, J.P.,Yang, M.J. Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen alpha Protein Cell 2015 6 757 766 5CFA 26349459 Crystal structures of Bbp from Staphylococcus aureus with peptide ligand 2015-07-08 2015-09-23 Zhang, X.Y.,Wu, M.,Zhuo, W.,Gu, J.K.,Zhang, S.S.,Ge, J.P.,Yang, M.J. Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen alpha Protein Cell 2015 6 757 766 4RZI 26358291 Crystal structure of PhaB from Synechocystis sp. PCC 6803 2014-12-22 2015-09-30 Liu, Y.,Feng, Y.,Cao, X.,Li, X.,Xue, S. Structure-directed construction of a high-performance version of the enzyme FabG from the photosynthetic microorganism Synechocystis sp. PCC 6803. Febs Lett. 2015 589 3052 3057 4XHT 26344098 Crystal structure of Timeless_PAB domain native form 2015-01-06 2015-09-30 Xie, S.,Mortusewicz, O.,Ma, H.T.,Herr, P.,Poon, R.R.,Helleday, T.,Qian, C. Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Mol.Cell 2015 60 163 176 4XHU 26344098 The complex structure of Timeless_PAB and PARP-1_catalytic domain 2015-01-06 2015-09-30 Xie, S.,Mortusewicz, O.,Ma, H.T.,Herr, P.,Poon, R.R.,Helleday, T.,Qian, C. Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Mol.Cell 2015 60 163 176 4XHW 26344098 Crystal structure of Timeless_PAB domain in SeMet-labelled form 2015-01-06 2015-09-30 Xie, S.,Mortusewicz, O.,Ma, H.T.,Herr, P.,Poon, R.R.,Helleday, T.,Qian, C. Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Mol.Cell 2015 60 163 176 3WZF Crystal structure of human cytoplasmic aspartate aminotransferase 2014-09-24 2015-10-07 Jiang, X.,Chang, H.,Zhou, Y.,Chen, L.,Yang, Q. Recombinant expression, purification and Preliminary crystallographic studies of human cytoplasmic aspartate aminotransferase To be Published 0 0 0 0 4RT4 25542209 Crystal structure of Dpy30 complexed with Bre2 2014-11-12 2015-10-07 Zhang, H.,Li, M.,Gao, Y.,Jia, C.,Pan, X.,Cao, P.,Zhao, X.,Zhang, J.,Chang, W. Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation Protein Cell 2015 6 147 151 4RTA 25542209 Cystal structure of the Dpy30 for MLL/SET1 COMPASS H3K4 trimethylation 2014-11-14 2015-10-07 Zhang, H.,Li, M.,Gao, Y.,Jia, C.,Pan, X.,Cao, P.,Zhao, X.,Zhang, J.,Chang, W. Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation. Protein Cell 2015 6 147 151 4Y33 26327385 Crystal of NO66 in complex with Ni(II)and N-oxalylglycine (NOG) 2015-02-10 2015-10-07 Wang, C.,Zhang, Q.,Hang, T.,Tao, Y.,Ma, X.,Wu, M.,Zhang, X.,Zang, J. Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr.,Sect.D 2015 71 1955 1964 4Y3O 26327385 Crystal structure of Ribosomal oxygenase NO66 in complex with substrate Rpl8 peptide and Ni(II) and cofactor N-oxalyglycine 2015-02-10 2015-10-07 Wang, C.,Zhang, Q.,Hang, T.,Tao, Y.,Ma, X.,Wu, M.,Zhang, X.,Zang, J. Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr.,Sect.D 2015 71 1955 1964 4Y4R 26327385 Crystal structure of ribosomal oxygenase NO66 dimer mutant 2015-02-11 2015-10-07 Wang, C.,Zhang, Q.,Hang, T.,Tao, Y.,Ma, X.,Wu, M.,Zhang, X.,Zang, J. Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr.,Sect.D 2015 71 1955 1964 4Z0C 26323037 Crystal structure of TLR13-ssRNA13 complex 2015-03-26 2015-10-07 Song, W.,Wang, J.,Han, Z.,Zhang, Y.,Zhang, H.,Wang, W.,Chang, J.,Xia, B.,Fan, S.,Zhang, D.,Wang, J.,Wang, H.W.,Chai, J. Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13 Nat.Struct.Mol.Biol. 2015 22 782 787 4XU5 26160948 Crystal structure of MvINS bound to a bromine-derived 14C Diacylglycerol (DAG) at 2.1A resolution 2015-01-25 2015-10-14 Ren, R.,Zhou, X.,He, Y.,Ke, M.,Wu, J.,Liu, X.,Yan, C.,Wu, Y.,Gong, X.,Lei, X.,Yan, S.F.,Radhakrishnan, A.,Yan, N. PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels Science 2015 349 187 191 4XU6 26160948 Crystal structure of cross-linked MvINS R77C trimer at 1.9A resolution 2015-01-25 2015-10-14 Ren, R.,Zhou, X.,He, Y.,Ke, M.,Wu, J.,Liu, X.,Yan, C.,Wu, Y.,Gong, X.,Lei, X.,Yan, S.F.,Radhakrishnan, A.,Yan, N. PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels Science 2015 349 187 191 4Z3D 26381805 Human carbonyl reductase 1 with glutathione in a protective configuration 2015-03-31 2015-10-14 Liang, Q.,Liu, R.,Du, S.,Ding, Y. Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione. J.Struct.Biol. 2015 192 138 144 4Z8I 26479246 Crystal structure of Branchiostoma belcheri tsingtauense peptidoglycan recognition protein 3 2015-04-09 2015-10-14 Wang, W.J.,Cheng, W.,Luo, M.,Yan, Q.,Yu, H.M.,Li, Q.,Cao, D.D.,Huang, S.,Xu, A.,Mariuzza, R.A.,Chen, Y.,Zhou, C.Z. Activity Augmentation of Amphioxus Peptidoglycan Recognition Protein BbtPGRP3 via Fusion with a Chitin Binding Domain Plos One 2015 10 0 0 4ZXM 26479246 Crystal structure of PGRP domain from Branchiostoma belcheri tsingtauense peptidoglycan recognition protein 3 2015-05-20 2015-10-14 Wang, W.J.,Cheng, W.,Luo, M.,Yan, Q.,Yu, H.M.,Li, Q.,Cao, D.D.,Huang, S.,Xu, A.,Mariuzza, R.A.,Chen, Y.,Zhou, C.Z. Activity Augmentation of Amphioxus Peptidoglycan Recognition Protein BbtPGRP3 via Fusion with a Chitin Binding Domain Plos One 2015 10 0 0 5DIK 26402328 Crystal structure of apo-lpg0406, a carboxymuconolactone decarboxylase family protein from Legionella pneumophila 2015-09-01 2015-10-14 Chen, X.,Hu, Y.,Yang, B.,Gong, X.,Zhang, N.,Niu, L.,Wu, Y.,Ge, H. Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila Protein Sci. 2015 24 2070 2075 5DIP 26402328 Crystal structure of lpg0406 in reduced form from Legionella pneumophila 2015-09-01 2015-10-14 Chen, X.,Hu, Y.,Yang, B.,Gong, X.,Zhang, N.,Niu, L.,Wu, Y.,Ge, H. Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila Protein Sci. 2015 24 2070 2075 4WYT 25734361 Crystal Structure of Scribble PDZ34 tandem at 2.6 Angstroms 2014-11-18 2015-10-21 Ren, J.,Feng, L.,Bai, Y.,Pei, H.,Yuan, Z.,Feng, W. Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule. Biochem.J. 2015 468 133 144 4WYU 25734361 Crystal Structure of Scribble PDZ34 tandem in complex with its target peptide 2014-11-18 2015-10-21 Ren, J.,Feng, L.,Bai, Y.,Pei, H.,Yuan, Z.,Feng, W. Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule. Biochem.J. 2015 468 133 144 4X0W 25744057 The crystal structure of mupain-1-17 in complex with murinised human uPA 2014-11-24 2015-10-21 Jiang, L.,Zhao, B.,Xu, P.,Srensen, H.P.,Jensen, J.K.,Christensen, A.,Hosseini, M.,Nielsen, N.C.,Jensen, K.J.,Andreasen, P.A.,Huang, M. Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. Int.J.Biochem.Cell Biol. 2015 62 88 92 4X1P 25744057 The crystal structure of mupain-1-17 in complex with murinised human uPA at pH4.6 2014-11-25 2015-10-21 Jiang, L.,Zhao, B.,Xu, P.,Srensen, H.P.,Jensen, J.K.,Christensen, A.,Hosseini, M.,Nielsen, N.C.,Jensen, K.J.,Andreasen, P.A.,Huang, M. Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. Int.J.Biochem.Cell Biol. 2015 62 88 92 5C3O 26429971 Crystal structure of the C-terminal truncated Neurospora crassa T7H (NcT7HdeltaC) in apo form 2015-06-17 2015-10-21 Li, W.,Zhang, T.,Ding, J. Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi Nucleic Acids Res. 2015 43 10026 10038 5C3P 26429971 Crystal structure of the full-length Neurospora crassa T7H in complex with alpha-KG 2015-06-17 2015-10-21 Li, W.,Zhang, T.,Ding, J. Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi Nucleic Acids Res. 2015 43 10026 10038 5C3Q 26429971 Crystal structure of the full-length Neurospora crassa T7H in complex with alpha-KG and thymine (T) 2015-06-17 2015-10-21 Li, W.,Zhang, T.,Ding, J. Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi Nucleic Acids Res. 2015 43 10026 10038 5C3R 26429971 Crystal structure of the full-length Neurospora crassa T7H in complex with alpha-KG and 5-hydroxymethyluracil (5hmU) 2015-06-17 2015-10-21 Li, W.,Zhang, T.,Ding, J. Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi Nucleic Acids Res. 2015 43 10026 10038 5C3S 26429971 Crystal structure of the full-length Neurospora crassa T7H in complex with alpha-KG and 5-formyluracil (5fU) 2015-06-17 2015-10-21 Li, W.,Zhang, T.,Ding, J. Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi Nucleic Acids Res. 2015 43 10026 10038 5CFF 26423004 Crystal structure of Miranda/Staufen dsRBD5 complex 2015-07-08 2015-10-21 Jia, M.,Shan, Z.,Yang, Y.,Liu, C.,Li, J.,Luo, Z.G.,Zhang, M.,Cai, Y.,Wen, W.,Wang, W. The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division Nat Commun 2015 6 8381 8381 3X1D 25407413 Crystal Structure of Atlastin from Drosophila melanogaster 2014-11-14 2015-10-28 Wu, F.,Hu, X.,Bian, X.,Liu, X.,Hu, J. Comparison of human and Drosophila atlastin GTPases Protein Cell 2015 6 139 146 4REG Crystal Structure Analysis of PF0642 2014-09-23 2015-10-28 He, J.H.,Zhou, H.,Liu, X.P. Structural and functional characterization of PF0642 To be Published 0 0 0 0 4RO0 Crystal structure of MthK gating ring in a ligand-free form 2014-10-27 2015-10-28 Dong, W.,Guo, R.,Chai, H.,Chen, Z.,Cui, H.,Ren, Z.,Li, Y.,Ye, S. The principle of cooperative gating in a calcium-gated K+ channel To be Published 0 0 0 0 4X1S 25545505 The crystal structure of mupain-1-16-D9A in complex with murinised human uPA at pH7.4 2014-11-25 2015-10-28 Zhao, B.,Xu, P.,Jiang, L.,Paaske, B.,Kromann-Hansen, T.,Jensen, J.K.,Srensen, H.P.,Liu, Z.,Nielsen, J.T.,Christensen, A.,Hosseini, M.,Srensen, K.K.,Nielsen, N.C.,Jensen, K.J.,Huang, M.,Andreasen, P.A. A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One 2014 9 0 0 5DJ5 26470846 Crystal structure of rice DWARF14 in complex with synthetic strigolactone GR24 2015-09-01 2015-10-28 Zhao, L.H.,Zhou, X.E.,Yi, W.,Wu, Z.,Liu, Y.,Kang, Y.,Hou, L.,de Waal, P.W.,Li, S.,Jiang, Y.,Scaffidi, A.,Flematti, G.R.,Smith, S.M.,Lam, V.Q.,Griffin, P.R.,Wang, Y.,Li, J.,Melcher, K.,Xu, H.E. Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3. Cell Res. 2015 25 1219 1236 4RLI Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 2014-10-17 2015-11-04 Zhu, L.,Ren, X.,Zhu, J.,Li, H. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 TO BE PUBLISHED 0 0 0 0 4RQE 26433229 human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec 2014-11-03 2015-11-04 Wang, C.,Guo, Y.,Tian, Q.,Jia, Q.,Gao, Y.,Zhang, Q.,Zhou, C.,Xie, W. SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res. 2015 43 10534 10545 4RQF 26433229 human Seryl-tRNA synthetase dimer complexed with one molecule of tRNAsec 2014-11-03 2015-11-04 Wang, C.,Guo, Y.,Tian, Q.,Jia, Q.,Gao, Y.,Zhang, Q.,Zhou, C.,Xie, W. SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res. 2015 43 10534 10545 4Y07 26457515 Crystal structure of the HECT domain of human WWP2 2015-02-05 2015-11-04 Gong, W.,Zhang, X.,Zhang, W.,Li, J.,Li, Z. Structure of the HECT domain of human WWP2 Acta Crystallogr.,Sect.F 2015 71 1251 1257 4YL9 26439766 Crystal Structure of wild-type of hsp14.1 from Sulfolobus solfatataricus P2 2015-03-05 2015-11-04 Liu, L.,Chen, J.Y.,Yang, B.,Wang, F.H.,Wang, Y.H.,Yun, C.H. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function Structure 2015 23 2066 2075 4YLB 26439766 Crystal Structure of A102D mutant of hsp14.1 from Sulfolobus solfatataricus P2 2015-03-05 2015-11-04 Liu, L.,Chen, J.Y.,Yang, B.,Wang, F.H.,Wang, Y.H.,Yun, C.H. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function Structure 2015 23 2066 2075 4YLC 26439766 Crystal Structure of Del-C4 mutant of hsp14.1 from Sulfolobus solfatataricus P2 2015-03-05 2015-11-04 Liu, L.,Chen, J.Y.,Yang, B.,Wang, F.H.,Wang, Y.H.,Yun, C.H. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function Structure 2015 23 2066 2075 5C8Y 26462166 Crystal structure of T2R-TTL-Plinabulin complex 2015-06-26 2015-11-04 Wang, Y.,Zhang, H.,Gigant, B.,Yu, Y.,Wu, Y.,Chen, X.,Lai, Q.,Yang, Z.,Chen, Q.,Yang, J. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J. 2016 283 102 111 5CB3 26481419 Structural Insights into the Mechanism of Escherichia coli Ymdb 2015-06-30 2015-11-04 Zhang, W.,Wang, C.,Song, Y.,Shao, C.,Zhang, X.,Zang, J. Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase J.Struct.Biol. 2015 192 478 486 5CB5 26481419 Structural Insights into the Mechanism of Escherichia coli Ymdb 2015-06-30 2015-11-04 Zhang, W.,Wang, C.,Song, Y.,Shao, C.,Zhang, X.,Zang, J. Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase J.Struct.Biol. 2015 192 478 486 5CQQ 26478222 Crystal structure of the Drosophila Zeste DNA binding domain in complex with DNA 2015-07-22 2015-11-04 Gao, G.N.,Wang, M.,Yang, N.,Huang, Y.,Xu, R.M. Structure of Zeste-DNA Complex Reveals a New Modality of DNA Recognition by Homeodomain-Like Proteins J.Mol.Biol. 2015 427 3824 3833 5DEU 26524525 Crystal structure of TET2-5hmC complex 2015-08-26 2015-11-04 Hu, L.,Lu, J.,Cheng, J.,Rao, Q.,Li, Z.,Hou, H.,Lou, Z.,Zhang, L.,Li, W.,Gong, W.,Liu, M.,Sun, C.,Yin, X.,Li, J.,Tan, X.,Wang, P.,Wang, Y.,Fang, D.,Cui, Q.,Yang, P.,He, C.,Jiang, H.,Luo, C.,Xu, Y. Structural insight into substrate preference for TET-mediated oxidation. Nature 2015 527 118 122 4RK8 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 2014-10-12 2015-11-11 Zhu, L.,Ren, X.,Zhu, J.,Li, H. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 TO BE PUBLISHED 0 0 0 0 4RKA Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347 2014-10-12 2015-11-11 Zhu, L.,Ren, X.,Zhu, J.,Li, H. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347 TO BE PUBLISHED 0 0 0 0 4WVX Crystal structure of a phosphotriesterase-like lactonase Gkap in native form 2014-11-07 2015-11-11 An, J.,Zhang, Y.,Yang, G.Y.,Feng, Y. Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides To Be Published 0 0 0 0 4XKL 26506893 Crystal structure of NDP52 ZF2 in complex with mono-ubiquitin 2015-01-12 2015-11-11 Xie, X.,Li, F.,Wang, Y.,Wang, Y.,Lin, Z.,Cheng, X.,Liu, J.,Chen, C.,Pan, L. Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2 Autophagy 2015 11 1775 1789 5C6Y 26458300 A sperm whale myoglobin double mutant L29H/F43Y Mb with a Tyr-heme cross-link 2015-06-24 2015-11-11 Yan, D.J.,Yuan, H.,Li, W.,Xiang, Y.,He, B.,Nie, C.M.,Wen, G.B.,Lin, Y.W.,Tan, X.S. How a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: a direct comparitive study of L29H/F43Y myoglobin Dalton Trans 2015 44 18815 18822 5DLJ 26478180 Crystal Structure of Cas-DNA-N1 complex 2015-09-05 2015-11-11 Wang, J.,Li, J.,Zhao, H.,Sheng, G.,Wang, M.,Yin, M.,Wang, Y. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. Cell 2015 163 840 853 5DQT 26478180 Crystal Structure of Cas-DNA-22 complex 2015-09-15 2015-11-11 Wang, J.,Li, J.,Zhao, H.,Sheng, G.,Wang, M.,Yin, M.,Wang, Y. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. Cell 2015 163 840 853 5DQU 26478180 Crystal Structure of Cas-DNA-10 complex 2015-09-15 2015-11-11 Wang, J.,Li, J.,Zhao, H.,Sheng, G.,Wang, M.,Yin, M.,Wang, Y. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. Cell 2015 163 840 853 5DQZ 26478180 Crystal Structure of Cas-DNA-PAM complex 2015-09-15 2015-11-11 Wang, J.,Li, J.,Zhao, H.,Sheng, G.,Wang, M.,Yin, M.,Wang, Y. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. Cell 2015 163 840 853 5E8H 26537048 Crystal structure of geranylfarnesyl pyrophosphate synthases 2 from Arabidopsis thaliana 2015-10-14 2015-11-11 Wang, C.,Chen, Q.,Fan, D.,Li, J.,Wang, G.,Zhang, P. Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant 2016 9 195 204 5E8K 26537048 Crystal structure of polyprenyl pyrophosphate synthase 2 from Arabidopsis thaliana 2015-10-14 2015-11-11 Wang, C.,Chen, Q.,Fan, D.,Li, J.,Wang, G.,Zhang, P. Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant 2016 9 195 204 5E8L 26537048 Crystal structure of geranylgeranyl pyrophosphate synthase 11 from Arabidopsis thaliana 2015-10-14 2015-11-11 Wang, C.,Chen, Q.,Fan, D.,Li, J.,Wang, G.,Zhang, P. Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant 2016 9 195 204 3X22 Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W 2014-12-06 2015-11-18 Bai, J.,Yang, J.,Zhou, Y.,Yang, Q. Structural basis of Escherichia coli nitroreductase NfsB triple mutants engineered for improved activity and regioselectivity toward the prodrug CB1954 PROCESS BIOCHEM 2015 50 1760 1766 4WXO SadC (300-487) from Pseudomonas aeruginosa PAO1 2014-11-14 2015-11-18 Liu, C.,Liu, S.,Gu, L. Crystal structure of SadC (300-487) from Pseudomonas aeruginosa PAO1 To Be Published 0 0 0 0 5BOB 26365348 Crystal Structure of the Meningitis Pathogen Streptococcus suis adhesion Fhb 2015-05-27 2015-11-18 Zhang, C.,Yu, Y.,Yang, M.,Jiang, Y. Expression, purification, crystallization and structure determination of the N terminal domain of Fhb, a factor H binding protein from Streptococcus suis. Biochem.Biophys.Res.Commun. 2015 466 413 417 5CI8 26518565 Crystal structure of human Tob in complex with inhibitor fragment 1 2015-07-11 2015-11-18 Bai, Y.,Tashiro, S.,Nagatoishi, S.,Suzuki, T.,Yan, D.,Liu, R.,Tsumoto, K.,Bartlam, M.,Yamamoto, T. Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach Protein Cell 2015 6 924 928 5CI9 26518565 Crystal structure of human Tob in complex with inhibitor fragment 6 2015-07-11 2015-11-18 Bai, Y.,Tashiro, S.,Nagatoishi, S.,Suzuki, T.,Yan, D.,Liu, R.,Tsumoto, K.,Bartlam, M.,Yamamoto, T. Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach Protein Cell 2015 6 924 928 5EC3 Structural insight into the catalyitc mechanism of human 4-Hydroxyphenylpyruvate dioxygenase 2015-10-20 2015-11-18 Yang, W.C.,Yang, G.F. Structural insight into the catalyitc mechanism of human 4-Hydroxyphenylpyruvate dioxygenase To be published 0 0 0 0 4R7L Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 2014-08-27 2015-11-25 Ouyang, P.,Cui, K.,Lu, W.,Huang, J. Human Leukotriene A4 Hydrolase in complex with SAHA To be Published 0 0 0 0 4RR4 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367 2014-11-06 2015-11-25 Zhu, L.,Ren, X.,Zhu, J.,Li, H. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367 TO BE PUBLISHED 0 0 0 0 4X0V 28838949 Structure of a GH5 family lichenase from Caldicellulosiruptor sp. F32 2014-11-24 2015-11-25 Meng, D.D.,Liu, X.,Dong, S.,Wang, Y.F.,Ma, X.Q.,Zhou, H.,Wang, X.,Yao, L.S.,Feng, Y.,Li, F.L. Structural Insights into the Substrate Specificity of a Glycoside Hydrolase Family 5 Lichenase from Caldicellulosiruptor sp. F32 Biochem. J. 2017 0 0 0 5BPE 26571192 Crystal structure of EV71 3Cpro in complex with a potent and selective Inhibitor 2015-05-28 2015-11-25 Zhai, Y.,Zhao, X.,Cui, Z.,Wang, M.,Wang, Y.,Li, L.,Sun, Q.,Yang, X.,Zeng, D.,Liu, Y.,Sun, Y.,Lou, Z.,Shang, L.,Yin, Z. Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease J.Med.Chem. 2015 58 9414 9420 5C11 Crystal Structure of Jarid1a PHD finger bound to histone H3C4me3 peptide 2015-06-12 2015-11-25 Huang, J.,Li, H. Crystal Structure of Jarid1a PHD finger bound to histone H3C4me3 peptide Nat Commun 2015 0 0 0 5C13 Crystal Structure of TAF3 PHD finger bound to histone H3C4me3 peptide 2015-06-12 2015-11-25 Huang, J.,Li, H. Crystal Structure of Jarid1a PHD finger bound to histone H3C4me3 peptide Nat Commun 2015 0 0 0 5C5S 26529257 Crystal Structure of human Myosin 9b RhoGAP domain at 2.2 angstrom 2015-06-22 2015-11-25 Kong, R.,Yi, F.,Wen, P.,Liu, J.,Chen, X.,Ren, J.,Li, X.,Shang, Y.,Nie, Y.,Wu, K.,Fan, D.,Zhu, L.,Feng, W.,Wu, J.Y. Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression J.Clin.Invest. 2015 125 4407 4420 5CVD 26543159 Crystal structure of human NRMT1 in complex with alpha-N-dimethylated human CENP-A peptide 2015-07-26 2015-11-25 Wu, R.,Yue, Y.,Zheng, X.,Li, H. Molecular basis for histone N-terminal methylation by NRMT1 Genes Dev. 2015 29 2337 2342 5CVE 26543159 Crystal Structure of human NRMT1 in complex with dimethylated fly H2B peptide and SAH 2015-07-26 2015-11-25 Wu, R.,Yue, Y.,Zheng, X.,Li, H. Molecular basis for histone N-terminal methylation by NRMT1 Genes Dev. 2015 29 2337 2342 5DOK 26551074 Crystal structure of Tetrahymena p45C 2015-09-11 2015-11-25 Wan, B.,Tang, T.,Upton, H.,Shuai, J.,Zhou, Y.,Li, S.,Chen, J.,Brunzelle, J.S.,Zeng, Z.,Collins, K.,Wu, J.,Lei, M. The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nat.Struct.Mol.Biol. 2015 22 1023 1026 5DWQ 26551522 Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17) 2015-09-22 2015-11-25 Boriack-Sjodin, P.A.,Jin, L.,Jacques, S.L.,Drew, A.,Sneeringer, C.,Scott, M.P.,Moyer, M.P.,Ribich, S.,Moradei, O.,Copeland, R.A. Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol. 2016 11 763 771 5DX0 26551522 Crystal structure of CARM1, sinefungin, and H3 peptide (R17) 2015-09-23 2015-11-25 Boriack-Sjodin, P.A.,Jin, L.,Jacques, S.L.,Drew, A.,Sneeringer, C.,Scott, M.P.,Moyer, M.P.,Ribich, S.,Moradei, O.,Copeland, R.A. Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol. 2016 11 763 771 5DX1 26551522 Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) 2015-09-23 2015-11-25 Boriack-Sjodin, P.A.,Jin, L.,Jacques, S.L.,Drew, A.,Sneeringer, C.,Scott, M.P.,Moyer, M.P.,Ribich, S.,Moradei, O.,Copeland, R.A. Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol. 2016 11 763 771 5DX8 26551522 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R455) 2015-09-23 2015-11-25 Boriack-Sjodin, P.A.,Jin, L.,Jacques, S.L.,Drew, A.,Sneeringer, C.,Scott, M.P.,Moyer, M.P.,Ribich, S.,Moradei, O.,Copeland, R.A. Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol. 2016 11 763 771 5DXA 26551522 Crystal structure of CARM1, sinefungin, and methylated PABP1 peptide (R460) 2015-09-23 2015-11-25 Boriack-Sjodin, P.A.,Jin, L.,Jacques, S.L.,Drew, A.,Sneeringer, C.,Scott, M.P.,Moyer, M.P.,Ribich, S.,Moradei, O.,Copeland, R.A. Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol. 2016 11 763 771 5DXJ 26551522 Crystal structure of CARM1 and sinefungin 2015-09-23 2015-11-25 Boriack-Sjodin, P.A.,Jin, L.,Jacques, S.L.,Drew, A.,Sneeringer, C.,Scott, M.P.,Moyer, M.P.,Ribich, S.,Moradei, O.,Copeland, R.A. Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol. 2016 11 763 771 5DZN 26487564 human T-cell immunoglobulin and mucin domain protein 4 2015-09-25 2015-11-25 Yuan, S.,Cao, L.,Ling, H.,Dang, M.,Sun, Y.,Zhang, X.,Chen, Y.,Zhang, L.,Su, D.,Wang, X.,Rao, Z. TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope. Protein Cell 2015 6 814 824 5DZO 26487564 Crystal structure of human T-cell immunoglobulin and mucin domain protein 1 2015-09-25 2015-11-25 Yuan, S.,Cao, L.,Ling, H.,Dang, M.,Sun, Y.,Zhang, X.,Chen, Y.,Zhang, L.,Su, D.,Wang, X.,Rao, Z. TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope. Protein Cell 2015 6 814 824 4RSN Crystal structure of the E267V mutant of cytochrome P450 BM3 2014-11-09 2015-12-02 Ren, X.K.,Yorke, J.A.,Taylor, A.,Zhang, A.L.,Zhang, T.,Zhou, W.H.,Wong, L.-L. Expanding the drug metabolism function of P450BM3 To be Published 0 0 0 0 4RSY Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7 2014-11-12 2015-12-02 Ouyang, P.,Lu, W.,Cui, K.,Huang, J. Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 To be Published 0 0 0 0 4RVB Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase 2014-11-25 2015-12-02 Ouyang, P.,Lu, W.,Cui, K.,Huang, J. Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase To be Published 0 0 0 0 4X30 Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution 2014-11-27 2015-12-02 Qi, X.,Zhou, A. Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution To Be Published 0 0 0 0 4YNL 26576507 Crystal structure of the hood domain of Anabaena HetR in complex with the hexapeptide ERGSGR derived from PatS 2015-03-10 2015-12-02 Hu, H.X.,Jiang, Y.L.,Zhao, M.X.,Cai, K.,Liu, S.,Wen, B.,Lv, P.,Zhang, Y.,Peng, J.,Zhong, H.,Yu, H.M.,Ren, Y.M.,Zhang, Z.,Tian, C.,Wu, Q.,Oliveberg, M.,Zhang, C.C.,Chen, Y.,Zhou, C.Z. Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation Sci Rep 2015 5 16470 16470 4YRV 26576507 Crystal structure of Anabaena transcription factor HetR complexed with 21-bp DNA from hetP promoter 2015-03-16 2015-12-02 Hu, H.X.,Jiang, Y.L.,Zhao, M.X.,Cai, K.,Liu, S.,Wen, B.,Lv, P.,Zhang, Y.,Peng, J.,Zhong, H.,Yu, H.M.,Ren, Y.M.,Zhang, Z.,Tian, C.,Wu, Q.,Oliveberg, M.,Zhang, C.C.,Chen, Y.,Zhou, C.Z. Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation Sci Rep 2015 5 16470 16470 5E04 26559827 Crystal structure of Andes virus nucleoprotein 2015-09-28 2015-12-02 Guo, Y.,Wang, W.,Sun, Y.,Ma, C.,Wang, X.,Wang, X.,Liu, P.,Shen, S.,Li, B.,Lin, J.,Deng, F.,Wang, H.,Lou, Z. Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation J.Virol. 2015 90 1048 1061 5E05 26559827 Structure of Sin Nombre virus nucleoprotein in shot-axis crystal form 2015-09-28 2015-12-02 Guo, Y.,Wang, W.,Sun, Y.,Ma, C.,Wang, X.,Wang, X.,Liu, P.,Shen, S.,Li, B.,Lin, J.,Deng, F.,Wang, H.,Lou, Z. Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation J.Virol. 2015 90 1048 1061 5E06 26559827 Structure of Sin Nombre virus nucleoprotein in long-axis crystal form 2015-09-28 2015-12-02 Guo, Y.,Wang, W.,Sun, Y.,Ma, C.,Wang, X.,Wang, X.,Liu, P.,Shen, S.,Li, B.,Lin, J.,Deng, F.,Wang, H.,Lou, Z. Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation J.Virol. 2015 90 1048 1061 3X3N 26396239 Crystal structure of EccB1 of Mycobacterium tuberculosis in spacegroup P21 2015-01-24 2015-12-09 Zhang, X.L.,Li, D.F.,Fleming, J.,Wang, L.W.,Zhou, Y.,Wang, D.C.,Zhang, X.E.,Bi, L.J. Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase. Faseb J. 2015 29 4804 4814 4P5A Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP 2014-03-15 2015-12-09 Li, Y.,Chen, W.,Li, J.,Xia, Z.,Deng, Z.,Zhou, J. Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi with 5-Br UMP To Be Published 0 0 0 0 4P5B Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br dUMP 2014-03-15 2015-12-09 Li, Y.,Chen, W.,Li, J.,Xia, Z.,Deng, Z.,Zhou, J. Crystal structure of a UMP/dUMP methylase PolB form Streptomyces cacaoi bound with 5-Br dUMP To Be Published 0 0 0 0 4WZF 26469317 Crystal structural basis for Rv0315, an immunostimulatory antigen and pseudo beta-1, 3-glucanase of Mycobacterium tuberculosis 2014-11-19 2015-12-09 Dong, W.,Huang, J.,Li, Y.,Tan, Y.,Shen, Z.,Song, Y.,Wang, D.,Xiao, S.,Chen, H.,Fu, Z.F.,Peng, G. Crystal structural basis for Rv0315, an immunostimulatory antigen and inactive beta-1,3-glucanase of Mycobacterium tuberculosis. Sci Rep 2015 5 15073 15073 4X5L 27386517 Crystal structure of Dscam1 Ig7 domain, isoform 9 2014-12-05 2015-12-09 Li, S.A.,Cheng, L.,Yu, Y.,Chen, Q. Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv 2016 2 0 0 5BOE 26627653 Crystal structure of Staphylococcus aureus enolase in complex with PEP 2015-05-27 2015-12-09 Wu, Y.,Wang, C.,Lin, S.,Wu, M.,Han, L.,Tian, C.,Zhang, X.,Zang, J. Octameric structure of Staphylococcus aureus enolase in complex with phosphoenolpyruvate Acta Crystallogr.,Sect.D 2015 71 2457 2470 5BOF 26627653 Crystal Structure of Staphylococcus aureus Enolase 2015-05-27 2015-12-09 Wu, Y.,Wang, C.,Lin, S.,Wu, M.,Han, L.,Tian, C.,Zhang, X.,Zang, J. Octameric structure of Staphylococcus aureus enolase in complex with phosphoenolpyruvate. Acta Crystallogr.,Sect.D 2015 71 2457 2470 5C3U 26367174 Crystal structure of a fungal L-serine ammonia-lyase from Rhizomucor miehei 2015-06-17 2015-12-09 Qin, Z.,Yan, Q.,Ma, Q.,Jiang, Z. Crystal structure and characterization of a novel l-serine ammonia-lyase from Rhizomucor miehei. Biochem.Biophys.Res.Commun. 2015 466 431 437 5EX7 Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA 2015-11-23 2015-12-09 Wang, Y.,Yu, Z.,Wang, M.,Liu, C.P.,Yang, N.,Xu, R.M. Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA To Be Published 0 0 0 0 4X83 27386517 Crystal structure of Dscam1 isoform 7.44, N-terminal four Ig domains 2014-12-10 2015-12-16 Li, S.A.,Cheng, L.,Yu, Y.,Chen, Q. Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv 2016 2 0 0 4X9B 27386517 Crystal structure of Dscam1 isoform 4.44, N-terminal four Ig domains 2014-12-11 2015-12-16 Li, S.A.,Cheng, L.,Yu, Y.,Chen, Q. Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv 2016 2 0 0 4XB7 27386517 Crystal structure of Dscam1 isoform 4.4, N-terminal four Ig domains 2014-12-16 2015-12-16 Li, S.A.,Cheng, L.,Yu, Y.,Chen, Q. Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition Sci Adv 2016 2 0 0 4XWT 25940620 Crystal structure of RNase J complexed with UMP 2015-01-29 2015-12-16 Zhao, Y.,Lu, M.,Zhang, H.,Hu, J.,Zhou, C.,Xu, Q.,Shah, A.M.U.H.,Xu, H.,Wang, L.,Hua, Y. Structural insights into catalysis and dimerization enhanced exonuclease activity of RNase J Nucleic Acids Res. 2015 43 5550 5559 4XWW 25940620 Crystal structure of RNase J complexed with RNA 2015-01-29 2015-12-16 Zhao, Y.,Lu, M.,Zhang, H.,Hu, J.,Zhou, C.,Xu, Q.,Shah, A.M.U.H.,Xu, H.,Wang, L.,Hua, Y. Structural insights into catalysis and dimerization enhanced exonuclease activity of RNase J Nucleic Acids Res. 2015 43 5550 5559 4YNZ 26626945 Structure of the N-terminal domain of SAD 2015-03-11 2015-12-16 Wu, J.X.,Cheng, Y.S.,Wang, J.,Chen, L.,Ding, M.,Wu, J.W. Structural insight into the mechanism of synergistic autoinhibition of SAD kinases Nat Commun 2015 6 8953 8953 4YOM 26626945 Structure of SAD kinase 2015-03-12 2015-12-16 Wu, J.X.,Cheng, Y.S.,Wang, J.,Chen, L.,Ding, M.,Wu, J.W. Structural insight into the mechanism of synergistic autoinhibition of SAD kinases Nat Commun 2015 6 8953 8953 5C1Q Serine/threonine-protein kinase pim-1 2015-06-15 2015-12-16 Li, W.,Wan, X.,Huang, N. Serine/threonine-protein kinase pim-1 To Be Published 0 0 0 0 5DUM 26635249 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 65C6 2015-09-19 2015-12-16 Zuo, T.,Sun, J.,Wang, G.,Jiang, L.,Zuo, Y.,Li, D.,Shi, X.,Liu, X.,Fan, S.,Ren, H.,Hu, H.,Sun, L.,Zhou, B.,Liang, M.,Zhou, P.,Wang, X.,Zhang, L. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection Nat Commun 2015 6 8855 8855 5DUP 26635249 Influenza A virus H5 hemagglutinin globular head in complex with antibody AVFluIgG03 2015-09-20 2015-12-16 Zuo, T.,Sun, J.,Wang, G.,Jiang, L.,Zuo, Y.,Li, D.,Shi, X.,Liu, X.,Fan, S.,Ren, H.,Hu, H.,Sun, L.,Zhou, B.,Liang, M.,Zhou, P.,Wang, X.,Zhang, L. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection Nat Commun 2015 6 8855 8855 5DUR 26635249 Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4 2015-09-20 2015-12-16 Zuo, T.,Sun, J.,Wang, G.,Jiang, L.,Zuo, Y.,Li, D.,Shi, X.,Liu, X.,Fan, S.,Ren, H.,Hu, H.,Sun, L.,Zhou, B.,Liang, M.,Zhou, P.,Wang, X.,Zhang, L. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection Nat Commun 2015 6 8855 8855 5DUT 26635249 Influenza A virus H5 hemagglutinin globular head 2015-09-20 2015-12-16 Zuo, T.,Sun, J.,Wang, G.,Jiang, L.,Zuo, Y.,Li, D.,Shi, X.,Liu, X.,Fan, S.,Ren, H.,Hu, H.,Sun, L.,Zhou, B.,Liang, M.,Zhou, P.,Wang, X.,Zhang, L. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection Nat Commun 2015 6 8855 8855 4RZK Crystal structure of Sulfolobus solfataricus Hsp20.1 ACD 2014-12-22 2015-12-23 Liang, L.,Yun, C.H. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem.Biophys.Res.Commun. 2015 0 0 0 4XBO 26202969 Crystal structure of full length E.coli TrmJ in complex with SAH 2014-12-17 2015-12-23 Liu, R.J.,Long, T.,Zhou, M.,Zhou, X.L.,Wang, E.D. tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily Nucleic Acids Res. 2015 43 7489 7503 5CET 26668313 Crystal structure of Rv2837c 2015-07-07 2015-12-23 He, Q.,Wang, F.,Liu, S.,Zhu, D.,Cong, H.,Gao, F.,Li, B.,Wang, H.,Lin, Z.,Liao, J.,Gu, L. Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase J.Biol.Chem. 2016 291 3668 3681 5BPJ 26690016 All Three Ca(2+)-binding Loops of Light-sensitive Ctenophore Photoprotein Berovin Bind Magnesium Ions: The Spatial Structure of Mg(2+)-loaded Apo-berovin 2015-05-28 2015-12-30 Burakova, L.P.,Natashin, P.V.,Malikova, N.P.,Niu, F.,Pu, M.,Vysotski, E.S.,Liu, Z.J. All Ca(2+)-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg(2+)-loaded apo-berovin. J. Photochem. Photobiol. B, Bi 2016 154 57 66 5DJN 26680000 Crystal structure of the Kinesin-3 KIF13A NC-CC1 mutant - Deletion of P390 2015-09-02 2015-12-30 Ren, J.,Huo, L.,Wang, W.,Zhang, Y.,Li, W.,Lou, J.,Xu, T.,Feng, W. Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A J.Biol.Chem. 2016 291 3581 3594 5DJO 26680000 Crystal structure of the CC1-FHA tandem of Kinesin-3 KIF13A 2015-09-02 2015-12-30 Ren, J.,Huo, L.,Wang, W.,Zhang, Y.,Li, W.,Lou, J.,Xu, T.,Feng, W. Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A J.Biol.Chem. 2016 291 3581 3594 5EU8 26656689 Structure of FIPV main protease in complex with dual inhibitors 2015-11-18 2015-12-30 Wang, F.,Chen, C.,Liu, X.,Yang, K.,Xu, X.,Yang, H. Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors J.Virol. 2015 90 1910 1917 4ZN2 26611635 Glycosyl hydrolase from Pseudomonas aeruginosa 2015-05-04 2016-01-06 Yu, S.,Su, T.,Wu, H.,Liu, S.,Wang, D.,Zhao, T.,Jin, Z.,Du, W.,Zhu, M.J.,Chua, S.L.,Yang, L.,Zhu, D.,Gu, L.,Ma, L.Z. PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix Cell Res. 2015 25 1352 1367 5E6N 26687600 Crystal structure of C. elegans LGG-2 2015-10-10 2016-01-06 Wu, F.,Watanabe, Y.,Guo, X.Y.,Qi, X.,Wang, P.,Zhao, H.Y.,Wang, Z.,Fujioka, Y.,Zhang, H.,Ren, J.Q.,Fang, T.C.,Shen, Y.X.,Feng, W.,Hu, J.J.,Noda, N.N.,Zhang, H. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy Mol.Cell 2015 60 914 929 5E6O 26687600 Crystal structure of C. elegans LGG-2 bound to an AIM/LIR motif 2015-10-10 2016-01-06 Wu, F.,Watanabe, Y.,Guo, X.Y.,Qi, X.,Wang, P.,Zhao, H.Y.,Wang, Z.,Fujioka, Y.,Zhang, H.,Ren, J.Q.,Fang, T.C.,Shen, Y.X.,Feng, W.,Hu, J.J.,Noda, N.N.,Zhang, H. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy Mol.Cell 2015 60 914 929 4X3O 28286128 Sirt2 in complex with a myristoyl peptide 2014-12-01 2016-01-13 Wang, Y.,Fung, Y.M.E.,Zhang, W.,He, B.,Chung, M.W.H.,Jin, J.,Hu, J.,Lin, H.,Hao, Q. Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. Cell Chem Biol 2017 24 339 345 4X3P 28286128 Sirt2 in complex with a myristoyl peptide 2014-12-01 2016-01-13 Wang, Y.,Fung, Y.M.E.,Zhang, W.,He, B.,Chung, M.W.H.,Jin, J.,Hu, J.,Lin, H.,Hao, Q. Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. Cell Chem Biol 2017 24 339 345 4XSO 26692049 Crystal structure of apo-form Alr3699/HepE from Anabaena sp. strain PCC 7120 2015-01-22 2016-01-13 Wang, X.P.,Jiang, Y.L.,Dai, Y.N.,Cheng, W.,Chen, Y.,Zhou, C.Z. Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology 2016 26 520 531 4XSP 26692049 Crystal structure of Anabaena Alr3699/HepE in complex with UDP 2015-01-22 2016-01-13 Wang, X.P.,Jiang, Y.L.,Dai, Y.N.,Cheng, W.,Chen, Y.,Zhou, C.Z. Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology 2016 26 520 531 4XSR 26692049 Crystal structure of Anabaena Alr3699/HepE in complex with UDP-glucose 2015-01-22 2016-01-13 Wang, X.P.,Jiang, Y.L.,Dai, Y.N.,Cheng, W.,Chen, Y.,Zhou, C.Z. Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology 2016 26 520 531 4XSU 26692049 Crystal structure of Anabaena Alr3699/HepE in complex with UDP and glucose 2015-01-22 2016-01-13 Wang, X.P.,Jiang, Y.L.,Dai, Y.N.,Cheng, W.,Chen, Y.,Zhou, C.Z. Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology 2016 26 520 531 5C74 27462434 Structure of a novel protein arginine methyltransferase 2015-06-24 2016-01-13 Lv, F.,Zhang, T.,Zhou, Z.,Gao, S.,Wong, C.C.,Zhou, J.Q.,Ding, J. Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Cell Discov 2015 1 15037 15037 5C77 27462434 A novel protein arginine methyltransferase 2015-06-24 2016-01-13 Lv, F.,Zhang, T.,Zhou, Z.,Gao, S.,Wong, C.C.,Zhou, J.Q.,Ding, J. Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Cell Discov 2015 1 15037 15037 5CRM 26731490 Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 2015-07-23 2016-01-13 Xue, X.,Zhang, Y.,Liu, Z.,Song, M.,Xing, Y.,Xiang, Q.,Wang, Z.,Tu, Z.,Zhou, Y.,Ding, K.,Xu, Y. Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem. 2016 59 1565 1579 5D0C 26731490 Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 2015-08-03 2016-01-13 Xue, X.,Zhang, Y.,Liu, Z.,Song, M.,Xing, Y.,Xiang, Q.,Wang, Z.,Tu, Z.,Zhou, Y.,Ding, K.,Xu, Y. Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem. 2016 59 1565 1579 5D7W 26750478 Crystal structure of serralysin 2015-08-14 2016-01-13 Wu, D.,Ran, T.,Wang, W.,Xu, D. Structure of a thermostable serralysin from Serratia sp. FS14 at 1.1 angstrom resolution. Acta Crystallogr.,Sect.F 2016 72 10 15 5ED8 26688217 Crystal structure of CC2-SUN of mouse SUN2 2015-10-21 2016-01-13 Nie, S.,Ke, H.,Gao, F.,Ren, J.,Wang, M.,Huo, L.,Gong, W.,Feng, W. Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators Structure 2016 24 80 91 5ED9 26688217 Crystal structure of CC1 of mouse SUN2 2015-10-21 2016-01-13 Nie, S.,Ke, H.,Gao, F.,Ren, J.,Wang, M.,Huo, L.,Gong, W.,Feng, W. Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators Structure 2016 24 80 91 4S1T Crystal structure of the mutant I26A/N52A of the endoribonuclease from human coronavirus 229E 2015-01-15 2016-01-20 Huo, T.,Liu, X.,Yang, C.,Rao, Z. Crystal structure and mutational analysis of the endoribonuclease from human coronavirus 229E To be Published 0 0 0 0 4XFQ 27128350 Crystal Structure Basis for PEDV 3C Like Protease 2014-12-28 2016-01-20 Ye, G.,Deng, F.,Shen, Z.,Luo, R.,Zhao, L.,Xiao, S.,Fu, Z.F.,Peng, G. Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease. Virology 2016 494 225 235 4ZNO 26711430 Crystal structure of Dln1 complexed with sucrose 2015-05-05 2016-01-20 Jia, N.,Liu, N.,Cheng, W.,Jiang, Y.L.,Sun, H.,Chen, L.L.,Peng, J.,Zhang, Y.,Ding, Y.H.,Zhang, Z.H.,Wang, X.,Cai, G.,Wang, J.,Dong, M.Q.,Zhang, Z.,Wu, H.,Wang, H.W.,Chen, Y.,Zhou, C.Z. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. Embo Rep. 2016 17 235 248 4ZNQ 26711430 Crystal structure of Dln1 complexed with Man(alpha1-2)Man 2015-05-05 2016-01-20 Jia, N.,Liu, N.,Cheng, W.,Jiang, Y.L.,Sun, H.,Chen, L.L.,Peng, J.,Zhang, Y.,Ding, Y.H.,Zhang, Z.H.,Wang, X.,Cai, G.,Wang, J.,Dong, M.Q.,Zhang, Z.,Wu, H.,Wang, H.W.,Chen, Y.,Zhou, C.Z. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. Embo Rep. 2016 17 235 248 4ZNR 26711430 Crystal structure of Dln1 complexed with Man(alpha1-3)Man 2015-05-05 2016-01-20 Jia, N.,Liu, N.,Cheng, W.,Jiang, Y.L.,Sun, H.,Chen, L.L.,Peng, J.,Zhang, Y.,Ding, Y.H.,Zhang, Z.H.,Wang, X.,Cai, G.,Wang, J.,Dong, M.Q.,Zhang, Z.,Wu, H.,Wang, H.W.,Chen, Y.,Zhou, C.Z. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. Embo Rep. 2016 17 235 248 5CJ8 26744311 Human Osteoclast Associated Receptor (OSCAR) extracellular domain 2015-07-14 2016-01-20 Haywood, J.,Qi, J.,Chen, C.C.,Lu, G.,Liu, Y.,Yan, J.,Shi, Y.,Gao, G.F. Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors. Proc.Natl.Acad.Sci.USA 2016 113 1038 1043 5CJB 26744311 Human Osteoclast Associated Receptor (OSCAR) in complex with a collagen-like peptide 2015-07-14 2016-01-20 Haywood, J.,Qi, J.,Chen, C.C.,Lu, G.,Liu, Y.,Yan, J.,Shi, Y.,Gao, G.F. Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors. Proc.Natl.Acad.Sci.USA 2016 113 1038 1043 5F18 26771495 Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1 2015-11-30 2016-01-20 Wang, H.,Shi, Y.,Song, J.,Qi, J.,Lu, G.,Yan, J.,Gao, G.F. Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1. Cell 2016 164 258 268 4YLY 26508479 Crystal structure of peptidyl-tRNA hydrolase from a Gram-positive bacterium, staphylococcus aureus at 2.25 angstrom resolution 2015-03-06 2016-01-27 Zhang, F.,Song, Y.,Niu, L.,Teng, M.,Li, X. Crystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a 2.25 angstrom resolution. Acta Biochim.Biophys.Sin. 2015 47 1005 1010 4Z69 25958880 Human serum albumin complexed with palmitic acid and diclofenac 2015-04-04 2016-01-27 Zhang, Y.,Lee, P.,Liang, S.,Zhou, Z.,Wu, X.,Yang, F.,Liang, H. Structural basis of non-steroidal anti-inflammatory drug diclofenac binding to human serum albumin. Chem.Biol.Drug Des. 2015 86 1178 1184 5AZC 26729647 Crystal structure of Escherichia coli Lgt in complex with phosphatidylglycerol 2015-09-30 2016-01-27 Mao, G.,Zhao, Y.,Kang, X.,Li, Z.,Zhang, Y.,Wang, X.,Sun, F.,Sankaran, K.,Zhang, X.C. Crystal structure of E. coli lipoprotein diacylglyceryl transferase Nat Commun 2016 7 10198 10198 5EIM 28735863 YTH domain-containing protein mmi1 and RNA complex 2015-10-30 2016-01-27 Wu, B.X.,Xu, J.H.,Su, S.C.,Liu, H.,Gan, J.,Ma, J.B. Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1 Biochem. Biophys. Res. Commun. 2017 491 310 316 5EIP 28735863 apo-structure of YTH domain of SpMmi1 2015-10-30 2016-01-27 Wu, B.X.,Xu, J.H.,Su, S.C.,Liu, H.,Gan, J.,Ma, J.B. Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1 Biochem. Biophys. Res. Commun. 2017 491 310 316 5F22 C-terminal domain of SARS-CoV nsp8 complex with nsp7 2015-12-01 2016-01-27 Li, S. C-terminal domain of SARS-CoV nsp8 complex with nsp7 To Be Published 0 0 0 0 4XRN Pilz domain with c-di-gmp of a protein from Pseudomonas aeruginosa 2015-01-21 2016-02-03 Chi, K.K.,Yuan, Z.L. Pilz domain with c-di-gmp of a protein from Pseudomonas aeruginosa To Be Published 0 0 0 0 4XSK Structure of PAItrap, an uPA mutant 2015-01-22 2016-02-03 Gong, L.,Proulle, V.,Hong, Z.,Lin, Z.,Liu, M.,Yuan, C.,Lin, L.,Furie, B.,Flaumenhaft, R.,Andreasen, P.,Furie, B.,Huang, M. Structure of PAItrap, an uPA mutant To Be Published 0 0 0 0 4YR9 26492815 mouse TDH with NAD+ bound 2015-03-14 2016-02-03 He, C.,Huang, X.,Liu, Y.,Li, F.,Yang, Y.,Tao, H.,Han, C.,Zhao, C.,Xiao, Y.,Shi, Y. Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis J.Struct.Biol. 2015 192 510 518 4YRA 26492815 mouse TDH in the apo form 2015-03-14 2016-02-03 He, C.,Huang, X.,Liu, Y.,Li, F.,Yang, Y.,Tao, H.,Han, C.,Zhao, C.,Xiao, Y.,Shi, Y. Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis J.Struct.Biol. 2015 192 510 518 4YRB 26492815 mouse TDH mutant R180K with NAD+ bound 2015-03-14 2016-02-03 He, C.,Huang, X.,Liu, Y.,Li, F.,Yang, Y.,Tao, H.,Han, C.,Zhao, C.,Xiao, Y.,Shi, Y. Structural insights on mouse l-threonine dehydrogenase: A regulatory role of Arg180 in catalysis J.Struct.Biol. 2015 192 510 518 4ZDT 26787556 Crystal structure of the RING finger domain of Slx1 in complex with the C-terminal domain of Slx4 2015-04-19 2016-02-03 Lian, F.M.,Xie, S.,Qian, C.M. Crystal structure and SUMO binding of Slx1-Slx4 complex Sci Rep 2016 6 19331 19331 5CHE 26794057 Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its regulatory proteins 2015-07-10 2016-02-03 Fang, Y.,Zhao, S.,Zhang, F.,Zhao, A.,Zhang, W.,Zhang, M.,Liu, L. The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein Sci Rep 2016 6 19756 19756 5DI0 26711430 Crystal structure of Dln1 2015-08-31 2016-02-03 Jia, N.,Liu, N.,Cheng, W.,Jiang, Y.L.,Sun, H.,Chen, L.L.,Peng, J.,Zhang, Y.,Ding, Y.H.,Zhang, Z.H.,Wang, X.,Cai, G.,Wang, J.,Dong, M.Q.,Zhang, Z.,Wu, H.,Wang, H.W.,Chen, Y.,Zhou, C.Z. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. Embo Rep. 2016 17 235 248 5ET0 26785147 Crystal structure of Myo3b-ARB2 in complex with Espin1-AR 2015-11-17 2016-02-03 Liu, H.,Li, J.,Raval, M.H.,Yao, N.,Deng, X.,Lu, Q.,Nie, S.,Feng, W.,Wan, J.,Yengo, C.M.,Liu, W.,Zhang, M. Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin Elife 2016 5 0 0 5ET1 26785147 Crystal structure of Myo3b-ARB1 in complex with Espin1-AR 2015-11-17 2016-02-03 Liu, H.,Li, J.,Raval, M.H.,Yao, N.,Deng, X.,Lu, Q.,Nie, S.,Feng, W.,Wan, J.,Yengo, C.M.,Liu, W.,Zhang, M. Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin Elife 2016 5 0 0 5F70 Crystal structures of human TIM members 2015-12-07 2016-02-03 Wang, H.,Qi, J.X.,Liu, N.N. Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors Chin.Sci.Bull. 2015 60 3438 3453 5F71 Human T-cell immunoglobulin and mucin domain protein 3 (hTIM-3) 2015-12-07 2016-02-03 Wang, H.,Qi, J.X.,Liu, N.N. Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors Chin.Sci.Bull. 2015 60 3438 3453 5F7F Human T-cell immunoglobulin and mucin domain protein 4 (hTIM-4) 2015-12-08 2016-02-03 Wang, H.,Qi, J.X.,Liu, N.N. Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors Chin.Sci.Bull. 2015 60 3438 3453 5F7H Human T-cell immunoglobulin and mucin domain protein 4 (hTIM-4) complex with phosphoserine 2015-12-08 2016-02-03 Wang, H.,Qi, J.X.,Liu, N.N. Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors Chin.Sci.Bull. 2015 60 3438 3453 5F9Q 27243566 Crystal structure of the extracellular domain of noncanonic ABC-type transporter YknZ from Gram-positive bacteria 2015-12-10 2016-02-03 Xu, Y.,Guo, J.,Wang, L.,Jiang, R.,Jin, X.,Liu, J.,Fan, S.,Quan, C.S.,Ha, N.C. The Crystal Structure of the YknZ Extracellular Domain of ABC Transporter YknWXYZ from Bacillus amyloliquefaciens. Plos One 2016 11 0 0 5FTB 26809678 Crystal structure of Pif1 helicase from Bacteroides in complex with AMPPNP 2016-01-12 2016-02-03 Chen, W.-F.,Dai, Y.-X.,Duan, X.-L.,Liu, N.-N.,Shi, W.,Li, N.,Li, M.,Dou, S.-X.,Dong, Y.-H.,Rety, S.,Xi, X.-G. Crystal Structures of the Bspif1 Helicase Reveal that a Major Movement of the 2B SH3 Domain is Required for DNA Unwinding Nucleic Acids Res. 2016 44 2949 0 5FTF 26809678 Crystal structure of Pif1 helicase from Bacteroides double mutant L95C-I339C 2016-01-13 2016-02-03 Chen, W.-F.,Dai, Y.-X.,Duan, X.-L.,Liu, N.-N.,Shi, W.,Li, N.,Li, M.,Dou, S.-X.,Dong, Y.-H.,Rety, S.,Xi, X.-G. Crystal Structures of the Bspif1 Helicase Reveal that a Major Movement of the 2B SH3 Domain is Required for DNA Unwinding Nucleic Acids Res. 2016 44 2949 0 4XYW Glycosyltransferases WbnH 2015-02-03 2016-02-10 Li, F. Glycosyltransferases WbnH To Be Published 0 0 0 0 4Z5V 26757803 Crystal Structure of MHV ns2 PDE Domain 2015-04-03 2016-02-10 Sui, B.K.,Huang, J.H.,Jha, B.K.,Yin, P.,Zhou, M.,Fu, Z.F.,Silverman, R.H.,Weiss, S.R.,Peng, G.Q.,Zhao, L. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation J.Gen.Virol. 2016 97 880 886 5FCG 26858413 Crystal structure of Bcl-2 in complex with HBx-BH3 motif 2015-12-15 2016-02-10 Jiang, T.Y.,Liu, M.H.,Wu, J.P.,Shi, Y.G. Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx Proc.Natl.Acad.Sci.USA 2016 0 0 0 4Y5U 27803324 Transcription factor 2015-02-12 2016-02-17 Li, J.,Rodriguez, J.P.,Niu, F.,Pu, M.,Wang, J.,Hung, L.W.,Shao, Q.,Zhu, Y.,Ding, W.,Liu, Y.,Da, Y.,Yao, Z.,Yang, J.,Zhao, Y.,Wei, G.H.,Cheng, G.,Liu, Z.J.,Ouyang, S. Structural basis for DNA recognition by STAT6 Proc.Natl.Acad.Sci.USA 2016 113 13015 13020 4R5Y 26208524 The complex structure of Braf V600E kinase domain with a novel Braf inhibitor 2014-08-22 2016-02-24 Tang, Z.,Yuan, X.,Du, R.,Cheung, S.H.,Zhang, G.,Wei, J.,Zhao, Y.,Feng, Y.,Peng, H.,Zhang, Y.,Du, Y.,Hu, X.,Gong, W.,Liu, Y.,Gao, Y.,Liu, Y.,Hao, R.,Li, S.,Wang, S.,Ji, J.,Zhang, L.,Li, S.,Sutton, D.,Wei, M.,Zhou, C.,Wang, L.,Luo, L. BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol.Cancer Ther. 2015 14 2187 2197 4XVG Crystal structure of Alkylhydroperoxide Reductase Subunit AhpF from Escherichia coli 2015-01-27 2016-02-24 Chen, C.F.,Gao, Z.Q.,Dong, Y.H.,Liu, Q.S. Crystal structure of Alkylhydroperoxide Reductase Subunit AhpF from Escherichia coli To Be Published 0 0 0 0 5AYW 26900875 Structure of a membrane complex 2015-09-14 2016-02-24 Han, L.,Zheng, J.,Wang, Y.,Yang, X.,Liu, Y.,Sun, C.,Cao, B.,Zhou, H.,Ni, D.,Lou, J.,Zhao, Y.,Huang, Y. Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins Nat.Struct.Mol.Biol. 2016 23 192 196 5BTU 26877021 The structure of Diels-Alderase PyrI4 in the biosynthetic pathway of pyrroindomycins 2015-06-03 2016-02-24 Zheng, Q.,Guo, Y.,Yang, L.,Zhao, Z.,Wu, Z.,Zhang, H.,Liu, J.,Cheng, X.,Wu, J.,Yang, H.,Jiang, H.,Pan, L.,Liu, W. Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4 Cell Chem Biol 2016 23 352 360 5BU3 26877021 Crystal Structure of Diels-Alderase PyrI4 in complex with its product 2015-06-03 2016-02-24 Zheng, Q.,Guo, Y.,Yang, L.,Zhao, Z.,Wu, Z.,Zhang, H.,Liu, J.,Cheng, X.,Wu, J.,Yang, H.,Jiang, H.,Pan, L.,Liu, W. Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4 Cell Chem Biol 2016 23 352 360 5EE9 26912459 Complex structure of OSYCHF1 with GMP-PNP 2015-10-22 2016-02-24 Cheung, M.-Y.,Li, X.,Miao, R.,Fong, Y.-H.,Li, K.-P.,Yung, Y.-L.,Yu, M.-H.,Wong, K.-B.,Chen, Z.,Lam, H.-M. ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses Proc.Natl.Acad.Sci.USA 2016 113 2648 2653 5F59 26886794 The crystal structure of MLL3 SET domain 2015-12-04 2016-02-24 Li, Y.,Han, J.,Zhang, Y.,Cao, F.,Liu, Z.,Li, S.,Wu, J.,Hu, C.,Wang, Y.,Shuai, J.,Chen, J.,Cao, L.,Li, D.,Shi, P.,Tian, C.,Zhang, J.,Dou, Y.,Li, G.,Chen, Y.,Lei, M. Structural basis for activity regulation of MLL family methyltransferases. Nature 2016 530 447 452 5F59 26886794 The crystal structure of MLL3 SET domain 2015-12-04 2016-02-24 Li, Y.,Han, J.,Zhang, Y.,Cao, F.,Liu, Z.,Li, S.,Wu, J.,Hu, C.,Wang, Y.,Shuai, J.,Chen, J.,Cao, L.,Li, D.,Shi, P.,Tian, C.,Zhang, J.,Dou, Y.,Li, G.,Chen, Y.,Lei, M. Structural basis for activity regulation of MLL family methyltransferases. Nature 2016 530 447 452 5F67 26853938 An exquisitely specific PDZ/target recognition revealed by the structure of INAD PDZ3 in complex with TRP channel tail 2015-12-05 2016-02-24 Ye, F.,Liu, W.,Shang, Y.,Zhang, M. An Exquisitely Specific PDZ/Target Recognition Revealed by the Structure of INAD PDZ3 in Complex with TRP Channel Tail Structure 2016 24 383 391 5F6L 26886794 The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L 2015-12-06 2016-02-24 Li, Y.,Han, J.,Zhang, Y.,Cao, F.,Liu, Z.,Li, S.,Wu, J.,Hu, C.,Wang, Y.,Shuai, J.,Chen, J.,Cao, L.,Li, D.,Shi, P.,Tian, C.,Zhang, J.,Dou, Y.,Li, G.,Chen, Y.,Lei, M. Structural basis for activity regulation of MLL family methyltransferases. Nature 2016 530 447 452 4YIA Structural mechanism of hormone release in thyroxine binding globulin 2015-03-01 2016-03-02 Zheng, Y. Structural mechanism of hormone release in thyroxine Binding globulin To Be Published 0 0 0 0 4Z5W 26308901 The plant peptide hormone receptor 2015-04-03 2016-03-02 Wang, J.,Li, H.,Han, Z.,Zhang, H.,Wang, T.,Lin, G.,Chang, J.,Yang, W.,Chai, J. Allosteric receptor activation by the plant peptide hormone phytosulfokine Nature 2015 525 265 268 4Z61 26308901 The plant peptide hormone receptor complex 2015-04-03 2016-03-02 Wang, J.,Li, H.,Han, Z.,Zhang, H.,Wang, T.,Lin, G.,Chang, J.,Yang, W.,Chai, J. Allosteric receptor activation by the plant peptide hormone phytosulfokine Nature 2015 525 265 268 4Z62 26308901 The plant peptide hormone free receptor 2015-04-03 2016-03-02 Wang, J.,Li, H.,Han, Z.,Zhang, H.,Wang, T.,Lin, G.,Chang, J.,Yang, W.,Chai, J. Allosteric receptor activation by the plant peptide hormone phytosulfokine Nature 2015 525 265 268 4Z63 26308901 The plant peptide hormone receptor in arabidopsis 2015-04-03 2016-03-02 Wang, J.,Li, H.,Han, Z.,Zhang, H.,Wang, T.,Lin, G.,Chang, J.,Yang, W.,Chai, J. Allosteric receptor activation by the plant peptide hormone phytosulfokine Nature 2015 525 265 268 4Z64 26308901 the plant peptide hormone receptor complex in arabidopsis 2015-04-03 2016-03-02 Wang, J.,Li, H.,Han, Z.,Zhang, H.,Wang, T.,Lin, G.,Chang, J.,Yang, W.,Chai, J. Allosteric receptor activation by the plant peptide hormone phytosulfokine Nature 2015 525 265 268 4ZHS 26869335 Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum 2015-04-27 2016-03-02 Li, Q.,Mu, Z.,Zhao, R.,Dahal, G.,Viola, R.E.,Liu, T.,Jin, Q.,Cui, S. Structural Insights into the Tetrameric State of Aspartate-beta-semialdehyde Dehydrogenases from Fungal Species Sci Rep 2016 6 21067 21067 4ZIC 26869335 Crystal Structure of Aspartate Semialdehyde Dehydrogenase with NADP from Trichophyton rubrum 2015-04-28 2016-03-02 Li, Q.,Mu, Z.,Zhao, R.,Dahal, G.,Viola, R.E.,Liu, T.,Jin, Q.,Cui, S. Structural Insights into the Tetrameric State of Aspartate-beta-semialdehyde Dehydrogenases from Fungal Species Sci Rep 2016 6 21067 21067 5D6J 26628098 Crystal structure of a mycobacterial protein 2015-08-12 2016-03-02 Li, W.,Gu, S.,Fleming, J.,Bi, L. Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria. Sci Rep 2015 5 15493 15493 4YJE 27462415 Crystal structure of APC-ARM in complexed with Amer1-A1 2015-03-03 2016-03-09 Zhang, Z.,Akyildiz, S.,Xiao, Y.,Gai, Z.,An, Y.,Behrens, J.,Wu, G. Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov 2015 1 15016 15016 4YJL 27462415 Crystal structure of APC-ARM in complexed with Amer1-A2 2015-03-03 2016-03-09 Zhang, Z.,Akyildiz, S.,Xiao, Y.,Gai, Z.,An, Y.,Behrens, J.,Wu, G. Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov 2015 1 15016 15016 4YK6 27462415 Crystal structure of APC-ARM in complexed with Amer1-A4 2015-03-04 2016-03-09 Zhang, Z.,Akyildiz, S.,Xiao, Y.,Gai, Z.,An, Y.,Behrens, J.,Wu, G. Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov 2015 1 15016 15016 4YLW Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound 2015-03-06 2016-03-09 Wu, D.,Ouyang, P.,Lu, W.,Huang, J. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound To Be Published 0 0 0 0 4YR6 27102061 Fab fragment of 5G6 in complex with epitope peptide 2015-03-14 2016-03-09 Tao, Y.,Zhang, X.,Liang, X.,Zang, J.,Mo, X.,Li, R. Structural basis for the specific inhibition of glycoprotein Ib alpha shedding by an inhibitory antibody. Sci Rep 2016 6 24789 24789 5CHL 26974124 Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex 2015-07-10 2016-03-09 Liang, X.,Shan, S.,Pan, L.,Zhao, J.,Ranjan, A.,Wang, F.,Zhang, Z.,Huang, Y.,Feng, H.,Wei, D.,Huang, L.,Liu, X.,Zhong, Q.,Lou, J.,Li, G.,Wu, C.,Zhou, Z. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1 Nat.Struct.Mol.Biol. 2016 23 317 323 5COA 26868105 Crystal structure of iridoid synthase at 2.2-angstrom resolution 2015-07-20 2016-03-09 Qin, L.,Zhu, Y.,Ding, Z.,Zhang, X.,Ye, S.,Zhang, R. Structure of iridoid synthase in complex with NADP(+)/8-oxogeranial reveals the structural basis of its substrate specificity. J.Struct.Biol. 2016 194 224 230 5COB 26868105 Crystal structure of iridoid synthase in complex with NADP+ and 8-oxogeranial at 2.65-angstrom resolution 2015-07-20 2016-03-09 Qin, L.,Zhu, Y.,Ding, Z.,Zhang, X.,Ye, S.,Zhang, R. Structure of iridoid synthase in complex with NADP(+)/8-oxogeranial reveals the structural basis of its substrate specificity. J.Struct.Biol. 2016 194 224 230 5DA1 A Dimerization-Dependent Mechanism Drives PRRSV NSP11 Functions As a Beta Interferon Antagonist and Endoribonuclease 2015-08-19 2016-03-09 Shi, Y.,Peng, G. A Dimerization-Dependent Mechanism Drives PRRSV NSP11 Functions As a Beta Interferon Antagonist and Endoribonuclease To Be Published 0 0 0 0 5EX0 26929412 Crystal structure of human SMYD3 in complex with a MAP3K2 peptide 2015-11-23 2016-03-09 Fu, W.,Liu, N.,Qiao, Q.,Wang, M.,Min, J.,Zhu, B.,Xu, R.M.,Yang, N. Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem. 2016 291 9173 9180 5EX3 26929412 Crystal structure of human SMYD3 in complex with a VEGFR1 peptide 2015-11-23 2016-03-09 Fu, W.,Liu, N.,Qiao, Q.,Wang, M.,Min, J.,Zhu, B.,Xu, R.M.,Yang, N. Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem. 2016 291 9173 9180 5HA9 28442756 Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer 2015-12-30 2016-03-09 Fu, L.,Wang, S.,Wang, X.,Wang, P.,Zheng, Y.,Yao, D.,Guo, M.,Zhang, L.,Ouyang, L. Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. Sci Rep 2016 6 3 3 5HH7 26876097 crystal structure of Arabidopsis ORC1b BAH-PHD cassette in complex with unmodified H3 peptide 2016-01-10 2016-03-09 Li, S.,Yang, Z.,Du, X.,Liu, R.,Wilkinson, A.W.,Gozani, O.,Jacobsen, S.E.,Patel, D.J.,Du, J. Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette Structure 2016 24 486 494 4Y25 26957546 Bacterial polysaccharide outer membrane secretin 2015-02-09 2016-03-16 Wang, Y.,Andole Pannuri, A.,Ni, D.,Zhou, H.,Cao, X.,Lu, X.,Romeo, T.,Huang, Y. Structural Basis for Translocation of a Biofilm-supporting Exopolysaccharide across the Bacterial Outer Membrane J.Biol.Chem. 2016 291 10046 10057 4YR8 26988444 Crystal structure of JNK in complex with a regulator protein 2015-03-14 2016-03-16 Liu, X.,Zhang, C.S.,Lu, C.,Lin, S.C.,Wu, J.W.,Wang, Z.X. A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation. Nat Commun 2016 7 10879 10879 4ZN3 26433031 Crystal Structure of MjSpt4:Spt5 complex conformation B 2015-05-04 2016-03-16 Guo, G.R.,Gao, Y.X.,Zhu, Z.L.,Zhao, D.,Liu, Z.,Zhou, H.H.,Niu, L.W.,Teng, M.K. Structural and biochemical insights into the DNA-binding mode of MjSpt4p:Spt5 complex at the exit tunnel of RNAPII J.Struct.Biol. 2015 192 418 425 5AX8 26902786 Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase 2015-07-20 2016-03-16 Jiang, X.,Wang, J.,Chang, H.,Zhou, Y. Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase Biosci Trends 2016 10 79 84 5CVC 26919519 Structure of maize serine racemase 2015-07-26 2016-03-16 Zou, L.,Song, Y.,Wang, C.,Sun, J.,Wang, L.,Cheng, B.,Fan, J. Crystal structure of maize serine racemase with pyridoxal 5'-phosphate. Acta Crystallogr.,Sect.F 2016 72 165 171 5EJO 26908650 Crystal structure of the winged helix domain in Chromatin assembly factor 1 subunit p90 2015-11-02 2016-03-16 Zhang, K.,Gao, Y.,Li, J.,Burgess, R.,Han, J.,Liang, H.,Zhang, Z.,Liu, Y. A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks Nucleic Acids Res. 2016 44 5083 5094 5F3X 26812017 Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM 2015-12-03 2016-03-16 Li, J.,He, Y.,Lu, Q.,Zhang, M. Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex Dev.Cell 2016 36 179 189 5F3Y 26812017 Crystal Structure of Myo7b N-MyTH4-FERM-SH3 in complex with Anks4b CEN 2015-12-03 2016-03-16 Li, J.,He, Y.,Lu, Q.,Zhang, M. Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex Dev.Cell 2016 36 179 189 4XSQ 26821753 Structure of a variable lymphocyte receptor-like protein Bf66946 from Branchiostoma floridae 2015-01-22 2016-03-23 Cao, D.D.,Liao, X.,Cheng, W.,Jiang, Y.L.,Wang, W.J.,Li, Q.,Chen, J.Y.,Chen, Y.,Zhou, C.Z. Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae. Sci Rep 2016 6 19951 19951 4YY0 The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) 2015-03-23 2016-03-23 Wang, F.,Qi, J.,Bi, Y.,Zhang, W.,Wang, M.,Wang, M.,Liu, J.,Yan, J.,Shi, Y.,Gao, G.F. Structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) To Be Published 0 0 0 0 4YY1 The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) in complex with human receptor analog 6'SLNLN 2015-03-23 2016-03-23 Wang, F.,Qi, J.,Bi, Y.,Zhang, W.,Wang, M.,Wang, M.,Liu, J.,Yan, J.,Shi, Y.,Gao, G.F. Structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) To Be Published 0 0 0 0 4YY7 The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) in complex with avian receptor analog 3'SLNLN 2015-03-23 2016-03-23 Wang, F.,Qi, J.,Bi, Y.,Zhang, W.,Wang, M.,Wang, M.,Liu, J.,Yan, J.,Shi, Y.,Gao, G.F. Structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) To Be Published 0 0 0 0 5D23 26939889 The crystal structure of STPR from Bombyx mori in complex with 13-bp DNA derived from the +290 site of fibroin gene 2015-08-05 2016-03-23 Yu, L.Y.,Cheng, W.,Zhou, K.,Li, W.F.,Yu, H.M.,Gao, X.,Shen, X.,Wu, Q.,Chen, Y.,Zhou, C.Z. Structures of an all-alpha protein running along the DNA major groove. Nucleic Acids Res. 2016 0 0 0 5D2Q 26939889 Crystal structure of STPR from Bombyx Mori in complex with 20-bp DNA derived from +290 site of the fibroin gene 2015-08-06 2016-03-23 Yu, L.Y.,Cheng, W.,Zhou, K.,Li, W.F.,Yu, H.M.,Gao, X.,Shen, X.,Wu, Q.,Chen, Y.,Zhou, C.Z. Structures of an all-alpha protein running along the DNA major groove. Nucleic Acids Res. 2016 0 0 0 5D2S 26939889 Crystal structure of STPR from Bombyx mori in complex with 18-bp DNA containing four repetitive units of ATAC 2015-08-06 2016-03-23 Yu, L.Y.,Cheng, W.,Zhou, K.,Li, W.F.,Yu, H.M.,Gao, X.,Shen, X.,Wu, Q.,Chen, Y.,Zhou, C.Z. Structures of an all-alpha protein running along the DNA major groove. Nucleic Acids Res. 2016 0 0 0 5E5W 26816272 Hemagglutinin-esterase-fusion mutant structure of influenza D virus 2015-10-09 2016-03-23 Song, H.,Qi, J.,Khedri, Z.,Diaz, S.,Yu, H.,Chen, X.,Varki, A.,Shi, Y.,Gao, G.F. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism PLoS Pathog. 2016 12 0 0 5E62 26816272 HEF-mut with Tr323 complex 2015-10-09 2016-03-23 Song, H.,Qi, J.,Khedri, Z.,Diaz, S.,Yu, H.,Chen, X.,Varki, A.,Shi, Y.,Gao, G.F. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism PLoS Pathog. 2016 12 0 0 5E64 26816272 Hemagglutinin-esterase-fusion protein structure of influenza D virus 2015-10-09 2016-03-23 Song, H.,Qi, J.,Khedri, Z.,Diaz, S.,Yu, H.,Chen, X.,Varki, A.,Shi, Y.,Gao, G.F. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism PLoS Pathog. 2016 12 0 0 5E65 26816272 The complex structure of Hemagglutinin-esterase-fusion mutant protein from the influenza D virus with receptor analog 9-O-Ac-3'SLN (Tr322) 2015-10-09 2016-03-23 Song, H.,Qi, J.,Khedri, Z.,Diaz, S.,Yu, H.,Chen, X.,Varki, A.,Shi, Y.,Gao, G.F. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism PLoS Pathog. 2016 12 0 0 5E66 26816272 The complex structure of Hemagglutinin-esterase-fusion mutant protein from the influenza D virus with receptor analog 9-N-Ac-Sia 2015-10-09 2016-03-23 Song, H.,Qi, J.,Khedri, Z.,Diaz, S.,Yu, H.,Chen, X.,Varki, A.,Shi, Y.,Gao, G.F. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism PLoS Pathog. 2016 12 0 0 5DP3 26987809 Crystal Structure of EV71 3C Proteinase in complex with compound 2 2015-09-12 2016-03-30 Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta 2016 1860 1299 1307 5DP4 26987809 Crystal Structure of EV71 3C Proteinase in complex with compound 3 2015-09-12 2016-03-30 Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta 2016 1860 1299 1307 5DP5 26987809 Crystal Structure of EV71 3C Proteinase in complex with compound 4 2015-09-12 2016-03-30 Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta 2016 1860 1299 1307 5DP6 26987809 Crystal Structure of EV71 3C Proteinase in complex with compound 7 2015-09-12 2016-03-30 Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta 2016 1860 1299 1307 5DP7 26987809 Crystal Structure of EV71 3C Proteinase in complex with compound 5 2015-09-12 2016-03-30 Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta 2016 1860 1299 1307 5DPA 26987809 Crystal Structure of EV71 3C Proteinase in complex with compound 6 2015-09-12 2016-03-30 Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta 2016 1860 1299 1307 5ESW 26968365 Crystal structure of Apo hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila 2015-11-17 2016-03-30 Zhang, N.,Gong, X.,Lu, M.,Chen, X.,Qin, X.,Ge, H. Crystal structures of Apo and GMP bound hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis J.Struct.Biol. 2016 194 311 316 5ESX 26968365 Crystal structure of hypoxanthine-guanine phosphoribosyltransferase complexed with GMP from Legionella pneumophila 2015-11-17 2016-03-30 Zhang, N.,Gong, X.,Lu, M.,Chen, X.,Qin, X.,Ge, H. Crystal structures of Apo and GMP bound hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis J.Struct.Biol. 2016 194 311 316 5FHF 26904952 Crystal structure of Bacteroides sp Pif1 in complex with ADP-AlF4 2015-12-22 2016-03-30 Zhou, X.,Ren, W.,Bharath, S.R.,Tang, X.,He, Y.,Chen, C.,Liu, Z.,Li, D.,Song, H. Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep 2016 14 2030 2039 5FHG 26904952 Structure of unliganded Pif1 from Bacteroides sp 2015-12-22 2016-03-30 Zhou, X.,Ren, W.,Bharath, S.R.,Tang, X.,He, Y.,Chen, C.,Liu, Z.,Li, D.,Song, H. Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep 2016 14 2030 2039 5FHH 26904952 Structure of human Pif1 helicase domain residues 200-641 2015-12-22 2016-03-30 Zhou, X.,Ren, W.,Bharath, S.R.,Tang, X.,He, Y.,Chen, C.,Liu, Z.,Li, D.,Song, H. Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1 Cell Rep 2016 14 2030 2039 5HV2 27001859 Rifampin phosphotransferase G527Y mutant from Listeria monocytogenes 2016-01-28 2016-03-30 Qi, X.,Lin, W.,Ma, M.,Wang, C.,He, Y.,He, N.,Gao, J.,Zhou, H.,Xiao, Y.,Wang, Y.,Zhang, P. Structural basis of rifampin inactivation by rifampin phosphotransferase Proc.Natl.Acad.Sci.USA 2016 113 3803 3808 4RFR 27015802 Complex structure of AlkB/rhein 2014-09-27 2016-04-06 Li, Q.,Huang, Y.,Liu, X.,Gan, J.,Chen, H.,Yang, C.G. Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage. J.Biol.Chem. 2016 291 11083 11093 4Z5S 28302170 Crystal structure of apo-form of aldehyde deformylating oxygenase from Synechocystis sp.PCC 6803 2015-04-03 2016-04-06 Wang, Q.,Bao, L.,Jia, C.,Li, M.,Li, J.J.,Lu, X. Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship BMC Biotechnol. 2017 17 31 31 4Z6G 27216888 Structure of NT domain 2015-04-05 2016-04-06 Yue, J.,Zhang, Y.,Liang, W.G.,Gou, X.,Lee, P.,Liu, H.,Lyu, W.,Tang, W.J.,Chen, S.Y.,Yang, F.,Liang, H.,Wu, X. In vivo epidermal migration requires focal adhesion targeting of ACF7. Nat Commun 2016 7 11692 11692 4ZUS 26764037 Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide REV-QW11 2015-05-17 2016-04-06 Yao, S.,Liu, J.,Qi, J.,Chen, R.,Zhang, N.,Liu, Y.,Wang, J.,Wu, Y.,Gao, G.F.,Xia, C. Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol. 2016 196 1943 1954 4ZUT 26764037 Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12 2015-05-17 2016-04-06 Yao, S.,Liu, J.,Qi, J.,Chen, R.,Zhang, N.,Liu, Y.,Wang, J.,Wu, Y.,Gao, G.F.,Xia, C. Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol. 2016 196 1943 1954 4ZUU 26764037 Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-CF9 2015-05-17 2016-04-06 Yao, S.,Liu, J.,Qi, J.,Chen, R.,Zhang, N.,Liu, Y.,Wang, J.,Wu, Y.,Gao, G.F.,Xia, C. Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol. 2016 196 1943 1954 4ZUW 26764037 Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12 2015-05-17 2016-04-06 Yao, S.,Liu, J.,Qi, J.,Chen, R.,Zhang, N.,Liu, Y.,Wang, J.,Wu, Y.,Gao, G.F.,Xia, C. Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol. 2016 196 1943 1954 5DNO 26673708 Crystal structure of Mmi1 YTH domain complex with RNA 2015-09-10 2016-04-06 Wang, C.Y.,Zhu, Y.W.,Bao, H.Y.,Jiang, Y.Y.,Xu, C.,Wu, J.H.,Shi, Y.Y. A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1 Nucleic Acids Res. 2016 44 969 982 5DNP 26673708 Crystal structure of Mmi1 YTH domain 2015-09-10 2016-04-06 Wang, C.Y.,Zhu, Y.W.,Bao, H.Y.,Jiang, Y.Y.,Xu, C.,Wu, J.H.,Shi, Y.Y. A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1 Nucleic Acids Res. 2016 44 969 982 5HJP 27011007 Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease 2016-01-13 2016-04-06 Stachel, S.J.,Zerbinatti, C.,Rudd, M.T.,Cosden, M.,Suon, S.,Nanda, K.K.,Wessner, K.,DiMuzio, J.,Maxwell, J.,Wu, Z.,Uslaner, J.M.,Michener, M.S.,Szczerba, P.,Brnardic, E.,Rada, V.,Kim, Y.,Meissner, R.,Wuelfing, P.,Yuan, Y.,Ballard, J.,Holahan, M.,Klein, D.J.,Lu, J.,Fradera, X.,Parthasarathy, G.,Uebele, V.N.,Chen, Z.,Li, Y.,Li, J.,Cooke, A.J.,Bennett, D.J.,Bilodeau, M.T.,Renger, J. Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J.Med.Chem. 2016 59 3489 3498 4YY9 The structure of hemagglutinin from a H6N1 influenza virus (A/Taiwan/2/2013) 2015-03-23 2016-04-13 Wang, F.,Qi, J.,Bi, Y.,Zhang, W.,Wang, M.,Wang, M.,Liu, J.,Yan, J.,Shi, Y.,Gao, G.F. Structure of hemagglutinin from a H6N1 influenza virus (A/Taiwan/2/2013) at 2.6 Angstroms resolution To Be Published 0 0 0 0 4YYA The structure of hemagglutinin from a H6N1 influenza virus (A/Taiwan/2/2013) in complex with avian receptor analog 3'SLNLN 2015-03-23 2016-04-13 Wang, F.,Qi, J.,Bi, Y.,Zhang, W.,Wang, M.,Wang, M.,Liu, J.,Yan, J.,Shi, Y.,Gao, G.F. Structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) To Be Published 0 0 0 0 4YYB The structure of hemagglutinin from a H6N1 influenza virus (A/Taiwan/2/2013) in complex with human receptor analog 6'SLNLN 2015-03-23 2016-04-13 Wang, F.,Qi, J.,Bi, Y.,Zhang, W.,Wang, M.,Wang, M.,Liu, J.,Yan, J.,Shi, Y.,Gao, G.F. Structure of hemagglutinin from a H6N1 influenza virus (A/Taiwan/2/2013) at 2.6 Angstroms resolution To Be Published 0 0 0 0 5IY3 27088990 Zika Virus Non-structural Protein NS1 2016-03-23 2016-04-13 Song, H.,Qi, J.,Haywood, J.,Shi, Y.,Gao, G.F. Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses Nat.Struct.Mol.Biol. 2016 23 456 458 4Z6Y Structure of the TBC1D7-TSC1 complex 2015-04-06 2016-04-20 Gai, Z.,Wu, G. Structure of the TBC1D7-TSC1 complex To Be Published 0 0 0 0 5DAJ 26844397 Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa 2015-08-20 2016-04-20 Chen, W.Z.,Wang, D.,Zhou, W.,Sang, H.,Liu, X.C.,Ge, Z.,Zhang, J.,Lan, L.,Yang, C.G.,Chen, H. Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa Mol.Microbiol. 2016 100 749 758 5DQR 27072131 The crystal structure of Arabidopsis 7-hydroxymethyl chlorophyll a reductase (HCAR) 2015-09-15 2016-04-20 Wang, X.,Liu, L. Crystal Structure and Catalytic Mechanism of 7-Hydroxymethyl Chlorophyll a Reductase J.Biol.Chem. 2016 291 13349 13359 5H9T 26844397 Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa 2015-12-29 2016-04-20 Chen, W.,Wang, D.,Zhou, W.,Sang, H.,Liu, X.,Ge, Z.,Zhang, J.,Lan, L.,Yang, C.G.,Chen, H. Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa. Mol. Microbiol. 2016 100 749 758 5HJB 27105114 AF9 YEATS in complex with histone H3 Crotonylation at K9 2016-01-12 2016-04-20 Li, Y.Y.,Sabari, B.R.,Panchenko, T.,Wen, H.,Zhao, D.,Guan, H.P.,Wan, L.,Huang, H.,Tang, Z.,Zhao, Y.,Roeder, R.G.,Shi, X.,Allis, C.D.,Li, H.T. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain Mol.Cell 2016 62 181 193 5HJC 27105114 BRD3 second bromodomain in complex with histone H3 acetylation at K18 2016-01-13 2016-04-20 Li, Y.Y.,Sabari, B.R.,Panchenko, T.,Wen, H.,Zhao, D.,Guan, H.P.,Wan, L.,Huang, H.,Tang, Z.,Zhao, Y.,Roeder, R.G.,Shi, X.,Allis, C.D.,Li, H.T. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain Mol.Cell 2016 62 181 193 5HJD 27105114 AF9 YEATS in complex with histone H3 Crotonylation at K18 2016-01-13 2016-04-20 Li, Y.Y.,Sabari, B.R.,Panchenko, T.,Wen, H.,Zhao, D.,Guan, H.P.,Wan, L.,Huang, H.,Tang, Z.,Zhao, Y.,Roeder, R.G.,Shi, X.,Allis, C.D.,Li, H.T. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Mol.Cell 2016 62 181 193 5HQT 27001440 Crystal structure of an aspartate/glutamate racemase from Escherichia coli O157 2016-01-22 2016-04-20 Liu, X.,Gao, F.,Ma, Y.,Liu, S.,Cui, Y.,Yuan, Z.,Kang, X. Crystal structure and molecular mechanism of an aspartate/glutamate racemase from Escherichia coli O157 Febs Lett. 2016 590 1262 1269 5HRA 27001440 Crystal structure of an aspartate/glutamate racemase in complex with D-aspartate 2016-01-23 2016-04-20 Liu, X.,Gao, F.,Ma, Y.,Liu, S.,Cui, Y.,Yuan, Z.,Kang, X. Crystal structure and molecular mechanism of an aspartate/glutamate racemase from Escherichia coli O157 Febs Lett. 2016 590 1262 1269 5HRC 27001440 Crystal structure of an aspartate/glutamate racemase in complex with L-aspartate 2016-01-23 2016-04-20 Liu, X.,Gao, F.,Ma, Y.,Liu, S.,Cui, Y.,Yuan, Z.,Kang, X. Crystal structure and molecular mechanism of an aspartate/glutamate racemase from Escherichia coli O157 Febs Lett. 2016 590 1262 1269 5I8B 27190605 CBP in complex with Cpd23 ((R)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one) 2016-02-18 2016-04-20 Taylor, A.M.,Cote, A.,Hewitt, M.C.,Pastor, R.,Leblanc, Y.,Nasveschuk, C.G.,Romero, F.A.,Crawford, T.D.,Cantone, N.,Jayaram, H.,Setser, J.,Murray, J.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Conery, A.R.,Cummings, R.T.,Dakin, L.A.,Flynn, E.M.,Huang, O.W.,Kaufman, S.,Keller, P.J.,Kiefer, J.R.,Lai, T.,Li, Y.,Liao, J.,Liu, W.,Lu, H.,Pardo, E.,Tsui, V.,Wang, J.,Wang, Y.,Xu, Z.,Yan, F.,Yu, D.,Zawadzke, L.,Zhu, X.,Zhu, X.,Sims, R.J.,Cochran, A.G.,Bellon, S.,Audia, J.E.,Magnuson, S.,Albrecht, B.K. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett. 2016 7 531 536 5I8G 27190605 CBP in complex with Cpd637 ((R)-4-methyl-6-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one) 2016-02-18 2016-04-20 Taylor, A.M.,Cote, A.,Hewitt, M.C.,Pastor, R.,Leblanc, Y.,Nasveschuk, C.G.,Romero, F.A.,Crawford, T.D.,Cantone, N.,Jayaram, H.,Setser, J.,Murray, J.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Conery, A.R.,Cummings, R.T.,Dakin, L.A.,Flynn, E.M.,Huang, O.W.,Kaufman, S.,Keller, P.J.,Kiefer, J.R.,Lai, T.,Li, Y.,Liao, J.,Liu, W.,Lu, H.,Pardo, E.,Tsui, V.,Wang, J.,Wang, Y.,Xu, Z.,Yan, F.,Yu, D.,Zawadzke, L.,Zhu, X.,Zhu, X.,Sims, R.J.,Cochran, A.G.,Bellon, S.,Audia, J.E.,Magnuson, S.,Albrecht, B.K. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett. 2016 7 531 536 4ZHU 26593397 Crystal structure of a bacterial repressor protein 2015-04-27 2016-04-27 Li, S.,Li, T.,Xu, Y.,Zhang, Q.,Zhang, W.,Che, S.,Liu, R.,Wang, Y.,Bartlam, M. Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 Sci Rep 2015 5 16915 16915 4ZHV 26593397 Crystal structure of a bacterial signalling protein 2015-04-27 2016-04-27 Li, S.,Li, T.,Xu, Y.,Zhang, Q.,Zhang, W.,Che, S.,Liu, R.,Wang, Y.,Bartlam, M. Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 Sci Rep 2015 5 16915 16915 4ZHW 26593397 Crystal structure of a bacterial signalling protein (N-terminal truncation) 2015-04-27 2016-04-27 Li, S.,Li, T.,Xu, Y.,Zhang, Q.,Zhang, W.,Che, S.,Liu, R.,Wang, Y.,Bartlam, M. Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 Sci Rep 2015 5 16915 16915 4ZHY 26593397 Crystal structure of a bacterial signalling complex 2015-04-27 2016-04-27 Li, S.,Li, T.,Xu, Y.,Zhang, Q.,Zhang, W.,Che, S.,Liu, R.,Wang, Y.,Bartlam, M. Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 Sci Rep 2015 5 16915 16915 5H98 27071000 Crystal structure of Geobacter metallireducens SMUG1 2015-12-26 2016-04-27 Zhang, Z.,Shen, J.,Yang, Y.,Li, J.,Cao, W.,Xie, W. Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1 Acs Chem.Biol. 2016 11 1729 1736 5H9I 27071000 Crystal structure of Geobacter metallireducens SMUG1 with xanthine 2015-12-28 2016-04-27 Zhang, Z.,Shen, J.,Yang, Y.,Li, J.,Cao, W.,Xie, W. Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1 Acs Chem.Biol. 2016 11 1729 1736 5HYZ 27081181 Crystal Structure of SCL7 in Oryza sativa 2016-02-02 2016-04-27 Li, S.,Zhao, Y.,Zhao, Z.,Wu, X.,Sun, L.,Liu, Q.,Wu, Y. Crystal Structure of the GRAS Domain of SCARECROW-LIKE7 in Oryza sativa. Plant Cell 2016 28 1025 1034 5I9F 27088764 Crystal structure of designed pentatricopeptide repeat protein dPPR-U10 in complex with its target RNA U10 2016-02-20 2016-04-27 Shen, C.,Zhang, D.,Guan, Z.,Liu, Y.,Yang, Z.,Yang, Y.,Wang, X.,Wang, Q.,Zhang, Q.,Fan, S.,Zou, T.,Yin, P. Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins. Nat Commun 2016 7 11285 11285 5J14 28179425 Crystal structure of endoglycoceramidase I from Rhodococ-cus equi in complex with GM3 2016-03-28 2016-04-27 Han, Y.B.,Chen, L.Q.,Li, Z.,Tan, Y.M.,Feng, Y.,Yang, G.Y. Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases J. Biol. Chem. 2017 292 4789 4800 5J7Z 28179425 Crystal structure of endoglycoceramidase I from Rhodococ-cus equi in complex with GM1 2016-04-07 2016-04-27 Han, Y.B.,Chen, L.Q.,Li, Z.,Tan, Y.M.,Feng, Y.,Yang, G.Y. Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases. J. Biol. Chem. 2017 292 4789 4800 5J8R 27134172 Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant 2016-04-08 2016-04-27 Li, H.,Yang, F.,Liu, C.,Xiao, P.,Xu, Y.F.,Liang, Z.L.,Liu, C.,Wang, H.M.,Wang, W.J.,Zheng, W.S.,Zhang, W.,Ma, X.Y.,He, D.F.,Song, X.Y.,Cui, F.A.,Xu, Z.G.,Yi, F.,Sun, J.P.,Yu, X. Crystal structure and substrate specificity of PTPN12. Cell Rep 2016 15 1 14 4ZL1 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18X at 1.86 A resolution 2015-05-01 2016-05-04 Huang, J.,Wu, D.,Ouyang, P.,Lu, W.,Pu, J. Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18XYW at 1.86 A resolution To Be Published 0 0 0 0 4ZLK Crystal structure of mouse myosin-5a in complex with calcium-bound calmodulin 2015-05-01 2016-05-04 Shen, M.,Zheng, S.,Zhang, W.,Lu, Z.,Ye, K.,Li, X. Structural basis for calcium regulation of myosin 5 motor function To Be Published 0 0 0 0 4ZMG Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 2015-05-04 2016-05-04 Ren, X.L.,Zhu, J.S.,Zhu, L.L.,Li, H.L. Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 To Be Published 0 0 0 0 4ZMM GGDEF domain of Dcsbis complexed with c-di-GMP 2015-05-04 2016-05-04 Chen, Y.,Liu, C.,Liu, S.,Chi, K.,Gu, L. Crystal structure of Dcsbis GGDEF domain complexed with c-di-GMP To Be Published 0 0 0 0 4ZMU Dcsbis, a diguanylate cyclase from Pseudomonas aeruginosa 2015-05-04 2016-05-04 Chen, Y.,Liu, C.,Liu, S.,Chi, K.,Gu, L. crystal structure of Dcsbis from Pseudomonas aeruginosa To Be Published 0 0 0 0 5BOA 27086582 Crystal Structure of the Meningitis Pathogen Streptococcus suis adhesion Fhb bound to the disaccharide receptor Gb2 2015-05-27 2016-05-04 Zhang, C.,Hao, H.,Yu, Y.,Kong, D.,Chen, S.,Jiang, H.,Yuan, Y.,Zheng, Y.,Yang, M.,Jiang, Y. Structural basis of the interaction between the meningitis pathogen Streptococcus suis adhesin Fhb and its human receptor. Febs Lett. 2016 590 1384 1392 5FB0 27129259 Crystal Structure of a PHD finger bound to histone H3 T3ph peptide 2015-12-13 2016-05-04 Zhang, X.,Zhao, D.,Xiong, X.,He, Z.,Li, H. Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C J.Biol.Chem. 2016 291 12786 12798 5FB1 27129259 Crystal Structure of a PHD finger bound to histone H3 K9me3 peptide 2015-12-13 2016-05-04 Zhang, X.,Zhao, D.,Xiong, X.,He, Z.,Li, H. Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C J.Biol.Chem. 2016 291 12786 12798 5HK8 Crystal structure of a methylesterase protein MES16 from Arabidopsis 2016-01-13 2016-05-04 Li, H.,Pu, H. Crystal structure of a methylesterase protein MES16 from Arabidopsis Biochem.Biophys.Res.Commun. 2016 0 0 0 5IMX 26979157 Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine 2016-03-07 2016-05-04 Zhang, P.,Dong, J.,Zhong, B.,Zhang, D.,Yuan, H.,Jin, C.,Xu, X.,Li, H.,Zhou, Y.,Liang, Z.,Ji, M.,Xu, T.,Song, G.,Zhang, L.,Chen, G.,Meng, X.,Sun, D.,Shih, J.,Zhang, R.,Hou, G.,Wang, C.,Jin, Y.,Yang, Q. Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors. Bioorg.Med.Chem.Lett. 2016 26 1910 1918 5J7E hEAG PAS domain 2016-04-06 2016-05-04 Xue, T.,Juan, S.,Xiaohong, Q. Crystal Structure of PAS domain from the hEAG Potassium Channel To Be Published 0 0 0 0 5JJU 27371563 Crystal structure of Rv2837c complexed with 5'-pApA and 5'-AMP 2016-04-25 2016-05-04 He, Q.,Wang, F.,Liu, S.,Zhu, D.,Cong, H.,Gao, F.,Li, B.,Wang, H.,Lin, Z.,Liao, J.,Gu, L. Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase J.Biol.Chem. 2016 291 14386 14387 5CDI 27072913 Chloroplast chaperonin 60b1 of Chlamydomonas 2015-07-04 2016-05-11 Zhang, S.,Zhou, H.,Yu, F.,Bai, C.,Zhao, Q.,He, J.,Liu, C. Structural insight into the cooperation of chloroplast chaperonin subunits Bmc Biol. 2016 14 29 29 5JHL 27158114 Crystal structure of zika virus envelope protein in complex with a flavivirus broadly-protective antibody 2016-04-21 2016-05-11 Dai, L.,Song, J.,Lu, X.,Deng, Y.Q.,Musyoki, A.M.,Cheng, H.,Zhang, Y.,Yuan, Y.,Song, H.,Haywood, J.,Xiao, H.,Yan, J.,Shi, Y.,Qin, C.F.,Qi, J.,Gao, G.F. Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody. Cell Host Microbe 2016 19 696 704 5JHM 27158114 Crystal structure of Zika virus Envelope protein 2016-04-21 2016-05-11 Dai, L.,Song, J.,Lu, X.,Deng, Y.Q.,Musyoki, A.M.,Cheng, H.,Zhang, Y.,Yuan, Y.,Song, H.,Haywood, J.,Xiao, H.,Yan, J.,Shi, Y.,Qin, C.F.,Qi, J.,Gao, G.F. Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody. Cell Host Microbe 2016 19 696 704 4ZKS The crystal structure of upain-1-W3A in complex with inactive uPA (uPA-S195A) at pH7.4 2015-04-30 2016-05-18 Jiang, L.,Andreasen, P.A.,Huang, M. The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4 To Be Published 0 0 0 0 4ZVV 27479743 Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 2015-05-18 2016-05-18 Boudreau, A.,Purkey, H.E.,Hitz, A.,Robarge, K.,Peterson, D.,Labadie, S.,Kwong, M.,Hong, R.,Gao, M.,Del Nagro, C.,Pusapati, R.,Ma, S.,Salphati, L.,Pang, J.,Zhou, A.,Lai, T.,Li, Y.,Chen, Z.,Wei, B.,Yen, I.,Sideris, S.,McCleland, M.,Firestein, R.,Corson, L.,Vanderbilt, A.,Williams, S.,Daemen, A.,Belvin, M.,Eigenbrot, C.,Jackson, P.K.,Malek, S.,Hatzivassiliou, G.,Sampath, D.,Evangelista, M.,O'Brien, T. Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat.Chem.Biol. 2016 12 779 786 5CHH 27119725 Crystal structure of transcriptional regulator CdpR from Pseudomonas aeruginosa 2015-07-10 2016-05-18 Zhao, J.R.,Yu, X.,Zhu, M.,Kang, H.P.,Ma, J.B.,Wu, M.,Gan, J.H.,Deng, X.,Liang, H.H. Structural and Molecular Mechanism of CdpR Involved in Quorum-Sensing and Bacterial Virulence in Pseudomonas aeruginosa Plos Biol. 2016 14 0 0 5D06 27088557 Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme 2015-08-02 2016-05-18 Zhai, L.,Feng, L.,Xia, L.,Yin, H.,Xiang, S. Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations. Nat Commun 2016 7 11229 11229 5D0F 27088557 Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (E564Q) in complex with maltopentaose 2015-08-03 2016-05-18 Zhai, L.,Feng, L.,Xia, L.,Yin, H.,Xiang, S. Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations. Nat Commun 2016 7 11229 11229 5DV2 27013054 Crystal structure of human CNOT6L in complex with cytidine-5'-monophosphate 2015-09-21 2016-05-18 Zhang, Q.,Yan, D.,Guo, E.,Ding, B.,Yang, W.,Liu, R.,Yamamoto, T.,Bartlam, M. Structural basis for inhibition of the deadenylase activity of human CNOT6L Febs Lett. 2016 590 1270 1279 5EB0 27113583 crystal form II of YfiB belonging to P41 2015-10-17 2016-05-18 Xu, M.,Yang, X.,Yang, X.-A.,Zhou, L.,Liu, T.-Z.,Fan, Z.,Jiang, T. Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system Protein Cell 2016 7 403 416 5EB2 27113583 Trp-bound YfiR 2015-10-17 2016-05-18 Xu, M.,Yang, X.,Yang, X.-A.,Zhou, L.,Liu, T.-Z.,Fan, Z.,Jiang, T. Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system Protein Cell 2016 7 403 416 5EB3 27113583 VB6-bound protein 2015-10-17 2016-05-18 Xu, M.,Yang, X.,Yang, X.-A.,Zhou, L.,Liu, T.-Z.,Fan, Z.,Jiang, T. Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system Protein Cell 2016 7 403 416 5EQN 27139827 Structure of phosphonate hydroxylase 2015-11-13 2016-05-18 Li, C.,Junaid, M.,Almuqri, E.A.,Hao, S.,Zhang, H. Structural analysis of a phosphonate hydroxylase with an access tunnel at the back of the active site. Acta Crystallogr.,Sect.F 2016 72 362 368 5IZU 27185935 A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function 2016-03-26 2016-05-18 Zeng, M.,Shang, Y.,Guo, T.,He, Q.,Yung, W.H.,Liu, K.,Zhang, M. A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function Proc.Natl.Acad.Sci.USA 2016 113 0 0 5J6R 27276427 Crystal structure of Human Papillomavirus Type 59 L1 pentamer 2016-04-05 2016-05-18 Li, Z.,Yan, X.,Yu, H.,Wang, D.,Song, S.,Li, Y.,He, M.,Hong, Q.,Zheng, Q.,Zhao, Q.,Gu, Y.,Zhang, J.,Janssen, M.E.,Cardone, G.,Olson, N.H.,Baker, T.S.,Li, S.,Xia, N. The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction. Structure 2016 24 874 885 5J8P Lys27-linked diubiquitin 2016-04-08 2016-05-18 Pan, M.,Gao, S.,Zheng, Y. Structure of Lys27-linked diubiquitin To Be Published 0 0 0 0 5BXJ 26780698 Complex of the Fk1 domain mutant A19T of FKBP51 with 4-Nitrophenol 2015-06-09 2016-05-25 Wu, D.,Tao, X.,Chen, Z.P.,Han, J.T.,Jia, W.J.,Zhu, N.,Li, X.,Wang, Z.,He, Y.X. The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells J. Hazard. Mater. 2016 307 193 201 5C90 27171654 Staphylococcus aureus ClpP mutant - Y63A 2015-06-26 2016-05-25 Ni, T.,Ye, F.,Liu, X.,Zhang, J.,Liu, H.,Li, J.,Zhang, Y.,Sun, Y.,Wang, M.,Luo, C.,Jiang, H.,Lan, L.,Gan, J.,Zhang, A.,Zhou, H.,Yang, C.-G. Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure Acs Chem.Biol. 2016 11 1964 1972 5CI6 27160427 Crystal structure of Arabidopsis thaliana MPK6 2015-07-11 2016-05-25 Wang, B.,Qin, X.,Wu, J.,Deng, H.,Li, Y.,Yang, H.,Chen, Z.,Liu, G.,Ren, D. Analysis of crystal structure of Arabidopsis MPK6 and generation of its mutants with higher activity Sci Rep 2016 6 25646 25646 5IL0 27281194 Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation 2016-03-04 2016-05-25 Wang, X.,Feng, J.,Xue, Y.,Guan, Z.,Zhang, D.,Liu, Z.,Gong, Z.,Wang, Q.,Huang, J.,Tang, C.,Zou, T.,Yin, P. Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex Nature 2016 534 575 578 5IME 27167326 Crystal structure of P21-activated kinase 1 (PAK1) in complex with compound 9 2016-03-06 2016-05-25 Rudolph, J.,Murray, L.J.,Ndubaku, C.O.,O'Brien, T.,Blackwood, E.,Wang, W.,Aliagas, I.,Gazzard, L.,Crawford, J.J.,Drobnick, J.,Lee, W.,Zhao, X.,Hoeflich, K.P.,Favor, D.A.,Dong, P.,Zhang, H.,Heise, C.E.,Oh, A.,Ong, C.C.,La, H.,Chakravarty, P.,Chan, C.,Jakubiak, D.,Epler, J.,Ramaswamy, S.,Vega, R.,Cain, G.,Diaz, D.,Zhong, Y. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J.Med.Chem. 2016 59 5520 5541 5C1U 27185390 Crystal structure of EV71 3C Proteinase in complex with Compound Xb 2015-06-15 2016-06-01 Zhang, L.,Huang, G.,Cai, Q.,Zhao, C.,Tang, L.,Ren, H.,Li, P.,Li, N.,Huang, J.,Chen, X.,Guan, Y.,You, H.,Chen, S.,Li, J.,Lin, T. Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J.Mol.Recognit. 2016 29 520 527 5C1Y 27185390 Crystal structure of EV71 3C Proteinase in complex with Compound 1 2015-06-15 2016-06-01 Zhang, L.,Huang, G.,Cai, Q.,Zhao, C.,Tang, L.,Ren, H.,Li, P.,Li, N.,Huang, J.,Chen, X.,Guan, Y.,You, H.,Chen, S.,Li, J.,Lin, T. Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71 J.Mol.Recognit. 2016 29 520 527 5EJ4 27213829 EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 15 min 2015-11-01 2016-06-01 Song, H.G.,Dong, C.,Qin, M.M.,Chen, Y.Z.,Sun, Y.R.,Liu, J.J.,Chan, W.,Guo, Z.H. A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc. 2016 138 7244 7247 5EJ5 27213829 EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 1.5 h 2015-11-01 2016-06-01 Song, H.G.,Dong, C.,Qin, M.M.,Chen, Y.Z.,Sun, Y.R.,Liu, J.J.,Chan, W.,Guo, Z.H. A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc. 2016 138 7244 7247 5EJ6 27213829 EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2min then soaked with isochorismate for 2 min 2015-11-01 2016-06-01 Song, H.G.,Dong, C.,Qin, M.M.,Chen, Y.Z.,Sun, Y.R.,Liu, J.J.,Chan, W.,Guo, Z.H. A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc. 2016 138 7244 7247 5EJ7 27213829 EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 21 s 2015-11-01 2016-06-01 Song, H.G.,Dong, C.,Qin, M.M.,Chen, Y.Z.,Sun, Y.R.,Liu, J.J.,Chan, W.,Guo, Z.H. A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc. 2016 138 7244 7247 5EJ8 27213829 EcMenD-ThDP-Mn2+ complex structure soaked with 2-ketoglutarate for 2 min 2015-11-01 2016-06-01 Song, H.G.,Dong, C.,Qin, M.M.,Chen, Y.Z.,Sun, Y.R.,Liu, J.J.,Chan, W.,Guo, Z.H. A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc. 2016 138 7244 7247 5EJ9 27213829 EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min 2015-11-01 2016-06-01 Song, H.G.,Dong, C.,Qin, M.M.,Chen, Y.Z.,Sun, Y.R.,Liu, J.J.,Chan, W.,Guo, Z.H. A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc. 2016 138 7244 7247 5EJA 27213829 EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and soaked with isochorismate for 7 min 2015-11-01 2016-06-01 Song, H.G.,Dong, C.,Qin, M.M.,Chen, Y.Z.,Sun, Y.R.,Liu, J.J.,Chan, W.,Guo, Z.H. A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc. 2016 138 7244 7247 5HTJ 27223615 Putative sugar kinases from Synechococcus elongatus PCC7942-D8A 2016-01-26 2016-06-08 Xie, Y.,Li, M.,Chang, W. Crystal Structures of Putative Sugar Kinases from Synechococcus Elongatus PCC 7942 and Arabidopsis Thaliana Plos One 2016 11 0 0 5HTV 27223615 Putative sugar kinases from Arabidopsis thaliana in complex with AMPPNP 2016-01-27 2016-06-08 Xie, Y.,Li, M.,Chang, W. Crystal Structures of Putative Sugar Kinases from Synechococcus Elongatus PCC 7942 and Arabidopsis Thaliana Plos One 2016 11 0 0 5HTX 27223615 Putative sugar kinases from Arabidopsis thaliana in complex with ADP 2016-01-27 2016-06-08 Xie, Y.,Li, M.,Chang, W. Crystal Structures of Putative Sugar Kinases from Synechococcus Elongatus PCC 7942 and Arabidopsis Thaliana Plos One 2016 11 0 0 5HTY 27223615 Sugar kinases from Synechococcus elongatus PCC7942-D221A 2016-01-27 2016-06-08 Xie, Y.,Li, M.,Chang, W. Crystal Structures of Putative Sugar Kinases from Synechococcus Elongatus PCC 7942 and Arabidopsis Thaliana Plos One 2016 11 0 0 5JCE 27238968 Crystal structure of OsCEBiP complex 2016-04-15 2016-06-08 Liu, S.M.,Wang, J.Z.,Han, Z.,Gong, X.,Zhang, H.,Chai, J.J. Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP Structure 2016 24 1192 1200 4ZUH 27128350 Complex structure of PEDV 3CLpro mutant (C144A) with a peptide substrate. 2015-05-16 2016-06-15 Ye, G.,Deng, F.,Shen, Z.,Luo, R.,Zhao, L.,Xiao, S.,Fu, Z.F.,Peng, G. Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease. Virology 2016 494 225 235 5C70 The structure of Aspergillus oryzae beta-glucuronidase 2015-06-24 2016-06-15 Feng, X.D.,Tang, H.,Han, B.J.,Lv, B.,Li, C. Enhancing the Thermostability of beta-Glucuronidase by Rationally Redesigning the Catalytic Domain Based on Sequence Alignment Strategy Ind Eng Chem Res 2016 55 5474 5483 5F1K 27251573 human CD38 in complex with nanobody MU1053 2015-11-30 2016-06-15 Li, T.,Qi, S.,Unger, M.,Hou, Y.N.,Deng, Q.W.,Liu, J.,Lam, C.M.,Wang, X.W.,Xin, D.,Zhang, P.,Koch-Nolte, F.,Hao, Q.,Zhang, H.,Lee, H.C.,Zhao, Y.J. Immuno-targeting the multifunctional CD38 using nanobody Sci Rep 2016 6 27055 27055 5F1O 27251573 human CD38 in complex with nanobody MU551 2015-11-30 2016-06-15 Li, T.,Qi, S.,Unger, M.,Hou, Y.N.,Deng, Q.W.,Liu, J.,Lam, C.M.,Wang, X.W.,Xin, D.,Zhang, P.,Koch-Nolte, F.,Hao, Q.,Zhang, H.,Lee, H.C.,Zhao, Y.J. Immuno-targeting the multifunctional CD38 using nanobody Sci Rep 2016 6 27055 27055 5F21 27251573 human CD38 in complex with nanobody MU375 2015-12-01 2016-06-15 Li, T.,Qi, S.,Unger, M.,Hou, Y.N.,Deng, Q.W.,Liu, J.,Lam, C.M.,Wang, X.W.,Xin, D.,Zhang, P.,Koch-Nolte, F.,Hao, Q.,Zhang, H.,Lee, H.C.,Zhao, Y.J. Immuno-targeting the multifunctional CD38 using nanobody Sci Rep 2016 6 27055 27055 5F54 27058167 Structure of RecJ complexed with dTMP 2015-12-04 2016-06-15 Cheng, K.,Xu, H.,Chen, X.,Wang, L.,Tian, B.,Zhao, Y.,Hua, Y. Structural basis for DNA 5 -end resection by RecJ Elife 2016 5 0 0 5F55 27058167 Structure of RecJ complexed with DNA 2015-12-04 2016-06-15 Cheng, K.,Xu, H.,Chen, X.,Wang, L.,Tian, B.,Zhao, Y.,Hua, Y. Structural basis for DNA 5 -end resection by RecJ Elife 2016 5 0 0 5F56 27058167 Structure of RecJ complexed with DNA and SSB-ct 2015-12-04 2016-06-15 Cheng, K.,Xu, H.,Chen, X.,Wang, L.,Tian, B.,Zhao, Y.,Hua, Y. Structural basis for DNA 5 -end resection by RecJ Elife 2016 5 0 0 5HDM 27303897 Crystal structure of Arabidopsis thaliana glutamate-1-semialdehyde-2,1-aminomutase 2016-01-05 2016-06-15 Song, Y.,Pu, H.,Jiang, T.,Zhang, L.,Ouyang, M. Crystal structure of glutamate-1-semialdehyde-2,1-aminomutase from Arabidopsis thaliana. Acta Crystallogr.,Sect.F 2016 72 448 456 5I9I 27078579 Crystal structure of LP_PLA2 in complex with Darapladib 2016-02-20 2016-06-15 Liu, Q.F.,Chen, X.D.,Chen, W.Y.,Yuan, X.J.,Su, H.X.,Shen, J.H.,Xu, Y.C. Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors J.Med.Chem. 2016 59 5115 5120 5IRI 27251228 Structure of the mouse SAD-B AIS-KA1 fragment 2016-03-13 2016-06-15 Ma, H.,Wu, J.X.,Wang, J.,Wang, Z.X.,Wu, J.W. Structure and inhibition analysis of the mouse SAD-B C-terminal fragment Biosci.Biotechnol.Biochem. 2016 0 0 0 5J19 27238966 phospho-Pon binding-induced Plk1 dimerization 2016-03-29 2016-06-15 Zhu, K.,Shan, Z.,Zhang, L.,Wen, W. Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity Structure 2016 24 1110 1119 5JPP Structure of limonene epoxide hydrolase mutant - H-2-H5 2016-05-04 2016-06-15 Li, G.,Zhang, H.,Sun, Z.,Liu, X.,Reetz, M.T. Multi-Parameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity and Activity of an Epoxide Hydrolase To be published 0 0 0 0 5JPP Structure of limonene epoxide hydrolase mutant - H-2-H5 2016-05-04 2016-06-15 Li, G.,Zhang, H.,Sun, Z.,Liu, X.,Reetz, M.T. Multi-Parameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity and Activity of an Epoxide Hydrolase To be published 0 0 0 0 5JPU Structure of limonene epoxide hydrolase mutant - H-2-H5 complex with (S,S)-cyclohexane-1,2-diol 2016-05-04 2016-06-15 Li, G.,Zhang, H.,Sun, Z.,Liu, X.,Reetz, M.T. Multi-Parameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity and Activity of an Epoxide Hydrolase To be published 0 0 0 0 5JPU Structure of limonene epoxide hydrolase mutant - H-2-H5 complex with (S,S)-cyclohexane-1,2-diol 2016-05-04 2016-06-15 Li, G.,Zhang, H.,Sun, Z.,Liu, X.,Reetz, M.T. Multi-Parameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity and Activity of an Epoxide Hydrolase To be published 0 0 0 0 4ZW1 Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer 2015-05-19 2016-06-22 Liu, B.,Zhang, S.,Guo, M.,Tian, M. Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer To Be Published 0 0 0 0 5C55 Crystal structure of the Y138F mutant of C.glutamicum N-acetylneuraminic acid lyase in complex with pyruvate 2015-06-19 2016-06-22 Shen, Y.,Zhou, J.,Xie, J. Crystal structure of the Y138F mutant of C.glutamicum N-acetylneuraminic acid lyase in complex with pyruvate To Be Published 0 0 0 0 5C5B Crystal Structure of Human APPL BAR-PH Heterodimer 2015-06-19 2016-06-22 Chen, Y.J.,Chen, B. Crystal Structure of Human APPL BAR-PH Heterodimer To Be Published 0 0 0 0 5F8G 27339134 Enterovirus 71 Polymerase Elongation Complex (C1S1 Form) 2015-12-09 2016-06-22 Shu, B.,Gong, P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA 2016 113 0 0 5F8H 27339134 Enterovirus 71 Polymerase Elongation Complex (C1S1/2 Form) 2015-12-09 2016-06-22 Shu, B.,Gong, P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA 2016 113 0 0 5F8I 27339134 Enterovirus 71 Polymerase Elongation Complex (C1S2/3 Form) 2015-12-09 2016-06-22 Shu, B.,Gong, P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA 2016 113 0 0 5F8J 27339134 Enterovirus 71 Polymerase Elongation Complex (C1S4 Form) 2015-12-09 2016-06-22 Shu, B.,Gong, P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA 2016 113 0 0 5F8L 27339134 Enterovirus 71 Polymerase Elongation Complex (C3S1 Form) 2015-12-09 2016-06-22 Shu, B.,Gong, P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA 2016 113 0 0 5F8M 27339134 Enterovirus 71 Polymerase Elongation Complex (C3S4/5 Form) 2015-12-09 2016-06-22 Shu, B.,Gong, P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA 2016 113 0 0 5F8N 27339134 Enterovirus 71 Polymerase Elongation Complex (C3S6 Form) 2015-12-09 2016-06-22 Shu, B.,Gong, P. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA 2016 113 0 0 5FB4 27309813 Crystal structure of the bacteriophage phi29 tail knob protein gp9 truncation variant 2015-12-14 2016-06-22 Xu, J.,Gui, M.,Wang, D.,Xiang, Y. The bacteriophage 29 tail possesses a pore-forming loop for cell membrane penetration. Nature 2016 534 544 547 5FB5 27309813 Crystal structure of the bacteriophage phi29 tail knob protein gp9 2015-12-14 2016-06-22 Xu, J.,Gui, M.,Wang, D.,Xiang, Y. The bacteriophage 29 tail possesses a pore-forming loop for cell membrane penetration. Nature 2016 534 544 547 5FEI 27309813 Crystal structure of the bacteriophage phi29 tail knob protein gp9 truncation variant 2015-12-17 2016-06-22 Xu, J.,Gui, M.,Wang, D.,Xiang, Y. The bacteriophage 29 tail possesses a pore-forming loop for cell membrane penetration. Nature 2016 534 544 547 5JCP 27311713 RhoGAP domain of ARAP3 in complex with RhoA in the transition state 2016-04-15 2016-06-22 Bao, H.,Li, F.,Wang, C.,Wang, N.,Jiang, Y.,Tang, Y.,Wu, J.,Shi, Y. Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3 J.Biol.Chem. 2016 291 16709 16719 5JD0 27311713 crystal structure of ARAP3 RhoGAP domain 2016-04-15 2016-06-22 Bao, H.,Li, F.,Wang, C.,Wang, N.,Jiang, Y.,Tang, Y.,Wu, J.,Shi, Y. Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3 J.Biol.Chem. 2016 291 16709 16719 5C71 29146597 The structure of Aspergillus oryzae a-glucuronidase complexed with glycyrrhetinic acid monoglucuronide 2015-06-24 2016-06-29 Lv, B.,Sun, H.,Huang, S.,Feng, X.,Jiang, T.,Li, C. Structure-guided engineering of the substrate specificity of a fungal beta-glucuronidase toward triterpenoid saponins. J.Biol.Chem. 2018 293 433 443 5C7Y ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 9min 2015-06-25 2016-06-29 Ming, D.-M.,Qi, Q.,Yang, W.-J.,Sun, K.-L.,Xu, T.-Y.,Huang, Q.,Hu, X.-J.,Lv, H. A Case Study of Lactonase ZHD To Be Published 0 0 0 0 5C81 ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 12min 2015-06-25 2016-06-29 Ming, D.-M.,Qi, Q.,Yang, W.-J.,Sun, K.-L.,Xu, T.-Y.,Huang, Q.,Hu, X.-J.,Lv, H. A Case Study of Lactonase ZHD To Be Published 0 0 0 0 5C8X ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 20min 2015-06-26 2016-06-29 Ming, D.-M.,Qi, Q.,Yang, W.-J.,Sun, K.-L.,Xu, T.-Y.,Huang, Q.,Hu, X.-J.,Lv, H. A Case Study of Lactonase ZHD To Be Published 0 0 0 0 5C8Z 28695844 ZHD-ZGR complex after ZHD crystal soaking in ZEN for 30min 2015-06-26 2016-06-29 Qi, Q.,Yang, W.J.,Zhou, H.J.,Ming, D.M.,Sun, K.L.,Xu, T.Y.,Hu, X.J.,Lv, H. The structure of a complex of the lactonohydrolase zearalenone hydrolase with the hydrolysis product of zearalenone at 1.60 angstrom resolution. Acta Crystallogr F Struct Biol 2017 73 376 381 5EFX 26820534 Crystal structure of Rho GTPase regulator 2015-10-26 2016-06-29 Jiang, Y.,Jiang, H.,Zhou, S.,Meng, B.,Liu, Z.J.,Ouyang, S. Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding Biochem.Biophys.Res.Commun. 2016 471 621 627 5FA8 27329856 SAM complex with aKMT from the hyperthermophilic archaeon Sulfolobus islandicu 2015-12-11 2016-06-29 Chu, Y.,Zhu, Y.,Chen, Y.,Li, W.,Zhang, Z.,Liu, D.,Wang, T.,Ma, J.,Deng, H.,Liu, Z.J.,Ouyang, S.,Huang, L. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism Mol.Cell Proteomics 2016 15 2908 2923 5FAD 27329856 SAH complex with aKMT from the hyperthermophilic archaeon Sulfolobus islandicus 2015-12-11 2016-06-29 Chu, Y.,Zhu, Y.,Chen, Y.,Li, W.,Zhang, Z.,Liu, D.,Wang, T.,Ma, J.,Deng, H.,Liu, Z.J.,Ouyang, S.,Huang, L. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism Mol.Cell Proteomics 2016 15 2908 2923 5JYY 27341624 Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses 2016-05-15 2016-06-29 Fu, L.,Bi, Y.,Wu, Y.,Zhang, S.,Qi, J.,Li, Y.,Lu, X.,Zhang, Z.,Lv, X.,Yan, J.,Gao, G.F.,Li, X. Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses J.Med.Chem. 2016 59 6303 6312 5B7B 27404920 Crystal structure of Nucleoprotein-nucleozin complex 2016-06-06 2016-07-06 Pang, B.,Cheung, N.N.,Zhang, W.Z.,Dai, J.,Kao, R.Y.,Zhang, H.M.,Hao, Q. Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites Sci Rep 2016 6 29684 29684 5B7B 27404920 Crystal structure of Nucleoprotein-nucleozin complex 2016-06-06 2016-07-06 Pang, B.,Cheung, N.N.,Zhang, W.Z.,Dai, J.,Kao, R.Y.,Zhang, H.M.,Hao, Q. Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites Sci Rep 2016 6 29684 29684 5IC7 27330138 Structure of the WD domain of UTP18 2016-02-22 2016-07-06 Zhang, C.,Sun, Q.,Chen, R.,Chen, X.,Lin, J.,Ye, K. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits Nucleic Acids Res. 2016 44 7475 7486 5IC8 27330138 Structure of UTP6 2016-02-23 2016-07-06 Zhang, C.,Sun, Q.,Chen, R.,Chen, X.,Lin, J.,Ye, K. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits Nucleic Acids Res. 2016 44 7475 7486 5IC9 27330138 Structure of the CTD complex of Utp12 and Utp13 2016-02-23 2016-07-06 Zhang, C.,Sun, Q.,Chen, R.,Chen, X.,Lin, J.,Ye, K. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits Nucleic Acids Res. 2016 44 7475 7486 5ICA 27330138 Structure of the CTD complex of UTP12, Utp13, Utp1 and Utp21 2016-02-23 2016-07-06 Zhang, C.,Sun, Q.,Chen, R.,Chen, X.,Lin, J.,Ye, K. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits Nucleic Acids Res. 2016 44 7475 7486 5ITQ 27354518 Crystal Structure of Human NEIL1, Free Protein 2016-03-17 2016-07-06 Zhu, C.,Lu, L.,Zhang, J.,Yue, Z.,Song, J.,Zong, S.,Liu, M.,Stovicek, O.,Gao, Y.Q.,Yi, C. Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA 2016 113 7792 7797 5ITT 27354518 Crystal Structure of Human NEIL1 bound to duplex DNA containing THF 2016-03-17 2016-07-06 Zhu, C.,Lu, L.,Zhang, J.,Yue, Z.,Song, J.,Zong, S.,Liu, M.,Stovicek, O.,Gao, Y.Q.,Yi, C. Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA 2016 113 7792 7797 5ITU 27354518 Crystal Structure of Human NEIL1(242K) bound to duplex DNA containing THF 2016-03-17 2016-07-06 Zhu, C.,Lu, L.,Zhang, J.,Yue, Z.,Song, J.,Zong, S.,Liu, M.,Stovicek, O.,Gao, Y.Q.,Yi, C. Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA 2016 113 7792 7797 5ITY 27354518 Crystal Structure of Human NEIL1(P2G) bound to duplex DNA containing Thymine Glycol 2016-03-17 2016-07-06 Zhu, C.,Lu, L.,Zhang, J.,Yue, Z.,Song, J.,Zong, S.,Liu, M.,Stovicek, O.,Gao, Y.Q.,Yi, C. Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair Proc.Natl.Acad.Sci.USA 2016 113 7792 7797 5KF4 29199991 Crystal structure of FN3 domain (Residues P368-P466) of Human collagen XX 2016-06-12 2016-07-06 Zhao, J.,Ren, J.,Wang, N.,Cheng, Z.,Yang, R.,Lin, G.,Guo, Y.,Cai, D.,Xie, Y.,Zhao, X. Crystal structure of the second fibronectin type III (FN3) domain from human collagen alpha 1 type XX Acta Crystallogr F Struct Biol 2017 73 695 700 5BMV 26660762 CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX 2015-05-23 2016-07-13 Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules. Mol.Pharmacol. 2016 89 233 242 5BWL Crystal Structure of SIRT5 in Complex with a Coumarin-Labelled Succinyl Peptide 2015-06-08 2016-07-13 Gai, W.,Jiang, H.,Liu, D. Crystal Structure of SIRT5 in Complex with a Coumarin-Labelled Succinyl Peptide To be published 0 0 0 0 5BWN 27501476 Crystal Structure of SIRT3 with a H3K9 Peptide Containing a Myristoyl Lysine 2015-06-08 2016-07-13 Gai, W.,Li, H.,Jiang, H.,Long, Y.,Liu, D. Crystal structures of SIRT3 reveal that the alpha 2-alpha 3 loop and alpha 3-helix affect the interaction with long-chain acyl lysine. Febs Lett. 2016 590 3019 3028 5BWO 27501476 Crystal Structure of Human SIRT3 in Complex with a Palmitoyl H3K9 Peptide 2015-06-08 2016-07-13 Gai, W.,Li, H.,Jiang, H.,Long, Y.,Liu, D. Crystal structures of SIRT3 reveal that the alpha 2-alpha 3 loop and alpha 3-helix affect the interaction with long-chain acyl lysine. Febs Lett. 2016 590 3019 3028 5CDJ 27179919 apical domain of chloroplast chaperonin 60a 2015-07-04 2016-07-13 Zhang, S.,Zhou, H.,Yu, F.,Gao, F.,He, J.,Liu, C. Functional Partition of Cpn60 alpha and Cpn60 beta Subunits in Substrate Recognition and Cooperation with Co-chaperonins Mol Plant 2016 9 1210 1213 5CDK 27179919 Apical domain of chloroplast chaperonin 60b1 2015-07-04 2016-07-13 Zhang, S.,Zhou, H.,Yu, F.,Gao, F.,He, J.,Liu, C. Functional Partition of Cpn60 alpha and Cpn60 beta Subunits in Substrate Recognition and Cooperation with Co-chaperonins Mol Plant 2016 9 1210 1213 5CF0 Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6 2015-07-08 2016-07-13 Li, J.,Shi, F.,Chen, D.-Q.,Cao, H.-L.,Xiong, B.,Shen, J.-K.,He, J.-H. FS23 binds to the N-terminal domain of human Hsp90: A novel small inhibitor for Hsp90 Nucl.Sci.Tech. 2015 26 60502 60502 5HPY 27363609 Crystal Structure of RhoA.GDP.MgF3-in complex with human Myosin 9b RhoGAP domain 2016-01-21 2016-07-13 Yi, F.,Kong, R.,Ren, J.,Zhu, L.,Lou, J.,Wu, J.Y.,Feng, W. Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism J.Mol.Biol. 2016 428 3043 3057 5HU9 27322145 Crystal structure of ABL1 in complex with CHMFL-074 2016-01-27 2016-07-13 Liu, F.,Wang, B.,Wang, Q.,Qi, Z.,Chen, C.,Kong, L.L.,Chen, J.Y.,Liu, X.,Wang, A.,Hu, C.,Wang, W.,Wang, H.,Wu, F.,Ruan, Y.,Qi, S.,Liu, J.,Zou, F.,Hu, Z.,Wang, W.,Wang, L.,Zhang, S.,Yun, C.H.,Zhai, Z.,Liu, J.,Liu, Q. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML) Oncotarget 2016 7 45562 45574 5JJA 27350047 Crystal structure of a PP2A B56gamma/BubR1 complex 2016-04-22 2016-07-13 Wang, J.,Wang, Z.,Yu, T.,Yang, H.,Virshup, D.M.,Kops, G.J.,Lee, S.H.,Zhou, W.,Li, X.,Xu, W.,Rao, Z. Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization. Protein Cell 2016 7 516 526 5CMW 27369074 Crystal structure of yeast Ent5 N-terminal domain-soaked in KI 2015-07-17 2016-07-20 Zhang, F.,Song, Y.,Ebrahimi, M.,Niu, L.,Teng, M.K.,Li, X. Structural and functional insight into the N-terminal domain of the clathrin adaptor Ent5 from Saccharomyces cerevisiae Biochem.Biophys.Res.Commun. 2016 477 786 793 5CMY 27369074 Crystal structure of yeast Ent5 N-terminal domain-native 2015-07-17 2016-07-20 Zhang, F.,Song, Y.,Ebrahimi, M.,Niu, L.,Teng, M.K.,Li, X. Structural and functional insight into the N-terminal domain of the clathrin adaptor Ent5 from Saccharomyces cerevisiae Biochem.Biophys.Res.Commun. 2016 477 786 793 5CN1 Crystal structure of yeast GGA1_GAE domain-P21 2015-07-17 2016-07-20 Zhang, F.,Song, Y.,Li, X.,Teng, M.K. Structural basis for the accessory protein recruitment by yeast GGA1_GAE domain To Be Published 0 0 0 0 5CN2 Crystal structure of yeast GGA1_GAE domain-C2221 2015-07-17 2016-07-20 Zhang, F.,Song, Y.,Li, X.,Teng, M.K. Structural basis for the accessory protein recruitment by yeast GGA1_GAE domain To Be Published 0 0 0 0 5CO4 Structural insights into the 2-OH methylation of C/U34 on tRNA 2015-07-19 2016-07-20 Xie, W.,Pang, P.,Wang, Z. Structural insights into the 2-OH methylation of C34 or U34 on tRNA To Be Published 0 0 0 0 5CO5 Crystal structure of Ac-AChBP in complex with conotoxin GIC 2015-07-19 2016-07-20 Wang, X.Q.,Xu, M.Y.,Luo, S.L.,Lin, B. Crystal structure of Ac-AChBP in complex with conotoxin GIC To Be Published 0 0 0 0 5E6M 27261259 Crystal structure of human wild type GlyRS bound with tRNAGly 2015-10-10 2016-07-20 Qin, X.,Deng, X.,Chen, L.,Xie, W. Crystal Structure of the Wild-Type Human GlyRS Bound with tRNA(Gly) in a Productive Conformation J.Mol.Biol. 2016 428 3603 3614 5HZR 27399259 Crystal structure of MtSnf2 2016-02-02 2016-07-20 Xia, X.,Liu, X.,Li, T.,Fang, X.,Chen, Z.C. Structure of chromatin remodeler Swi2/Snf2 in the resting state Nat.Struct.Mol.Biol. 2016 23 722 729 5IQL 27103431 Crystal structure of YEATS2 YEATS bound to H3K27cr peptide 2016-03-11 2016-07-20 Zhao, D.,Guan, H.,Zhao, S.,Mi, W.,Wen, H.,Li, Y.,Zhao, Y.,Allis, C.D.,Shi, X.,Li, H. YEATS2 is a selective histone crotonylation reader. Cell Res. 2016 26 629 632 4ZHQ 26660762 Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex 2015-04-26 2016-07-27 Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules Mol.Pharmacol. 2016 89 233 242 4ZI7 26660762 CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-HTI286 COMPLEX 2015-04-27 2016-07-27 Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules Mol.Pharmacol. 2016 89 233 242 4ZOL 26660762 Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex 2015-05-06 2016-07-27 Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules Mol.Pharmacol. 2016 89 233 242 5C93 28994408 Histidine kinase with ATP 2015-06-26 2016-07-27 Cai, Y.,Su, M.,Ahmad, A.,Hu, X.,Sang, J.,Kong, L.,Chen, X.,Wang, C.,Shuai, J.,Han, A. Conformational dynamics of the essential sensor histidine kinase WalK. Acta Crystallogr D Struct Biol 2017 73 793 803 5CSD 28111099 Ligand binding domain 2 of Penicillium marneffei MP1 protein in complex with arachidonic acids 2015-07-23 2016-07-27 Sze, K.H.,Lam, W.H.,Zhang, H.,Ke, Y.H.,Tse, M.K.,Woo, P.C.,Lau, S.K.,Lau, C.C.,Cai, J.P.,Tung, E.T.,Lo, R.K.,Xu, S.,Kao, R.Y.,Hao, Q.,Yuen, K.Y. Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response Cell Chem Biol 2017 24 182 194 5HBA 27391278 Globular Domain of Zebrafish Complement 1qA protein 2015-12-31 2016-07-27 Yuan, H.,Chen, R.,Tariq, M.,Liu, Y.,Sun, Y.,Xia, C. Crystal structure of zebrafish complement 1qA globular domain. Protein Sci. 2016 25 1883 1889 5I9E 27457955 Crystal structure of a nuclear actin ternary complex 2016-02-20 2016-07-27 Cao, T.,Sun, L.,Jiang, Y.,Huang, S.,Wang, J.,Chen, Z. Crystal structure of a nuclear actin ternary complex. Proc.Natl.Acad.Sci.USA 2016 113 8985 8990 5CX3 27246247 Crystal structure of FYCO1 LIR in complex with LC3A 2015-07-28 2016-08-03 Cheng, X.,Wang, Y.,Gong, Y.,Li, F.,Guo, Y.,Hu, S.,Liu, J.,Pan, L. Structural basis of FYCO1 and MAP1LC3A interaction reveals a novel binding mode for Atg8-family proteins. Autophagy 2016 12 1330 1339 5CZW 28188295 Crystal structure of myroilysin 2015-08-01 2016-08-03 Xu, D.,Zhou, J.,Lou, X.,He, J.,Ran, T.,Wang, W. Myroilysin is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Activated by a Cysteine-switch Mechanism J. Biol. Chem. 2017 292 5195 5206 5FOL 27431220 Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of isoeucine (Ile2AA) 2015-11-24 2016-08-03 Palencia, A.,Liu, R.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.,Li, X.,Alley, M.R.K.,Freund, Y.R.,Rosenthal, P.J.,Hakimi, M.,Cusack, S. Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother. 2016 60 5817 0 5GHE 27381865 Crystal Structure of Bacillus thuringiensis Cry6Aa2 Protoxin 2016-06-19 2016-08-03 Huang, J.,Guan, Z.,Wan, L.,Zou, T.,Sun, M. Crystal structure of Cry6Aa: A novel nematicidal ClyA-type alpha-pore-forming toxin from Bacillus thuringiensis Biochem.Biophys.Res.Commun. 2016 478 307 313 5HZG 27479325 The crystal structure of the strigolactone-induced AtD14-D3-ASK1 complex 2016-02-02 2016-08-03 Yao, R.,Ming, Z.,Yan, L.,Li, S.,Wang, F.,Ma, S.,Yu, C.,Yang, M.,Chen, L.,Chen, L.,Li, Y.,Yan, C.,Miao, D.,Sun, Z.,Yan, J.,Sun, Y.,Wang, L.,Chu, J.,Fan, S.,He, W.,Deng, H.,Nan, F.,Li, J.,Rao, Z.,Lou, Z.,Xie, D. DWARF14 is a non-canonical hormone receptor for strigolactone Nature 2016 536 469 473 5BPP 27126280 Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ 2015-05-28 2016-08-10 Xiao, Q.,Dong, N.N.,Yao, X.,Wu, D.,Lu, Y.,Mao, F.,Zhu, J.,Li, J.,Huang, J.,Chen, A.,Huang, L.,Wang, X.,Yang, G.,He, G.,Xu, Y.,Lu, W.Q. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H Sci Rep 2016 6 25298 25298 5DDS 26714051 Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PLP 2015-08-25 2016-08-10 Zhu, Y.,Xu, J.,Mei, X.,Feng, Z.,Zhang, L.,Zhang, Q.,Zhang, G.,Zhu, W.,Liu, J.,Zhang, C. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis Acs Chem.Biol. 2016 11 943 952 5E4K 27247422 Structure of ligand binding region of uPARAP at pH 7.4 2015-10-06 2016-08-10 Yuan, C.,Jurgensen, H.J.,Engelholm, L.H.,Li, R.,Liu, M.,Jiang, L.,Luo, Z.,Behrendt, N.,Huang, M. Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding Biochem.J. 2016 473 2359 2368 5EW6 27247422 Structure of ligand binding region of uPARAP at pH 7.4 without calcium 2015-11-20 2016-08-10 Yuan, C.,Jurgensen, H.J.,Engelholm, L.H.,Li, R.,Liu, M.,Jiang, L.,Luo, Z.,Behrendt, N.,Huang, M. Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding Biochem.J. 2016 473 2359 2368 5GMZ 27458651 Hepatitis B virus core protein Y132A mutant in complex with 4-methyl heteroaryldihydropyrimidine 2016-07-18 2016-08-10 Qiu, Z.,Lin, X.,Zhou, M.,Liu, Y.,Zhu, W.,Chen, W.,Zhang, W.,Guo, L.,Liu, H.,Wu, G.,Huang, M.,Jiang, M.,Xu, Z.,Zhou, Z.,Qin, N.,Ren, S.,Qiu, H.,Zhong, S.,Zhang, Y.,Zhang, Y.,Wu, X.,Shi, L.,Shen, F.,Mao, Y.,Zhou, X.,Yang, W.,Wu, J.Z.,Yang, G.,Mayweg, A.V.,Shen, H.C.,Tang, G. Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors J.Med.Chem. 2016 59 7651 7666 5D8E crystal structure of SSB from homo sapiens 2015-08-17 2016-08-17 Li, Y.H.,Gao, Z.Q.,Dong, Y.H. crystal structure of SSB from homo sapiens To Be Published 0 0 0 0 5D8F crystal structure of SSB and ssDNA complex from homo sapiens 2015-08-17 2016-08-17 Li, Y.H.,Gao, Z.Q.,Dong, Y.H. crystal structure of SSB and ssDNA complex from homo sapiens To Be Published 0 0 0 0 5IX1 27528681 Crystal structure of mouse Morc3 ATPase-CW cassette in complex with AMPPNP and H3K4me3 peptide 2016-03-23 2016-08-17 Li, S.,Yen, L.,Pastor, W.A.,Johnston, J.B.,Du, J.,Shew, C.J.,Liu, W.,Ho, J.,Stender, B.,Clark, A.T.,Burlingame, A.L.,Daxinger, L.,Patel, D.J.,Jacobsen, S.E. Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin Proc.Natl.Acad.Sci.USA 2016 113 0 0 5DAB Crystal structure of FTO-IN115 2015-08-19 2016-08-24 Chai, J.,Zhou, B.,Liu, W.,Han, Z.,Niu, T. Crystal structure of FTO-IN115 To Be Published 0 0 0 0 5DDT 27821871 Crystal structure of IspD from Bacillus subtilis at 1.80 Angstroms resolution, crystal form I 2015-08-25 2016-08-31 Jin, Y.,Liu, Z.,Li, Y.,Liu, W.,Tao, Y.,Wang, G. A structural and functional study on the 2-C-methyl-d-erythritol-4-phosphate cytidyltransferase (IspD) from Bacillus subtilis. Sci Rep 2016 6 36379 36379 5KIT 27541271 Crystal Structure of Nicotinamide Phosphoribosyltransferase (Nampt) in Complex with Inhibitors 37 2016-06-17 2016-08-31 Zak, M.,Yuen, P.W.,Liu, X.,Patel, S.,Sampath, D.,Oeh, J.,Liederer, B.M.,Wang, W.,O'Brien, T.,Xiao, Y.,Skelton, N.,Hua, R.,Sodhi, J.,Wang, Y.,Zhang, L.,Zhao, G.,Zheng, X.,Ho, Y.C.,Bair, K.W.,Dragovich, P.S. Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. J.Med.Chem. 2016 59 8345 8368 5B7W 27599864 Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv.campestris 2016-06-10 2016-09-07 Zhao, Z.,Wu, Z.,Zhang, J. Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv. campestris Acta Crystallogr.,Sect.F 2016 72 720 725 5CRL 27641146 Crystal Structure of the Transcription Activator Tn501 MerR in Complex with Mercury (II) 2015-07-23 2016-09-07 Wang, D.,Huang, S.,Liu, P.,Liu, X.,He, Y.,Chen, W.,Hu, Q.,Wei, T.,Gan, J.,Ma, J.,Chen, H. Structural Analysis of the Hg(II)-Regulatory Protein Tn501 MerR from Pseudomonas aeruginosa. Sci Rep 2016 6 33391 33391 5DIJ 27748753 The crystal structure of CT 2015-09-01 2016-09-07 Zhang, J.,Liu, N.,Cacho, R.A.,Gong, Z.,Liu, Z.,Qin, W.,Tang, C.,Tang, Y.,Zhou, J. Structural basis of nonribosomal peptide macrocyclization in fungi Nat.Chem.Biol. 2016 12 1001 1003 5DLK 27748753 The crystal structure of CT mutant 2015-09-06 2016-09-07 Zhang, J.,Liu, N.,Cacho, R.A.,Gong, Z.,Liu, Z.,Qin, W.,Tang, C.,Tang, Y.,Zhou, J. Structural basis of nonribosomal peptide macrocyclization in fungi Nat.Chem.Biol. 2016 12 1001 1003 5FEJ 27599732 CopM in the Cu(I)-bound form 2015-12-17 2016-09-07 Zhao, S.,Wang, X.,Niu, G.,Dong, W.,Wang, J.,Fang, Y.,Lin, Y.,Liu, L. Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM. Acta Crystallogr D Struct Biol 2016 72 997 1005 5FFA 27599732 CopM (with an N-terminal His-tag) in the apo form 2015-12-18 2016-09-07 Zhao, S.,Wang, X.,Niu, G.,Dong, W.,Wang, J.,Fang, Y.,Lin, Y.,Liu, L. Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM. Acta Crystallogr D Struct Biol 2016 72 997 1005 5FFB 27599732 CopM in the apo form 2015-12-18 2016-09-07 Zhao, S.,Wang, X.,Niu, G.,Dong, W.,Wang, J.,Fang, Y.,Lin, Y.,Liu, L. Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM. Acta Crystallogr D Struct Biol 2016 72 997 1005 5FFC 27599732 CopM in the Cu(II)-bound form 2015-12-18 2016-09-07 Zhao, S.,Wang, X.,Niu, G.,Dong, W.,Wang, J.,Fang, Y.,Lin, Y.,Liu, L. Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM. Acta Crystallogr D Struct Biol 2016 72 997 1005 5FFD 27599732 CopM in the Ag-bound form (by co-crystallization) 2015-12-18 2016-09-07 Zhao, S.,Wang, X.,Niu, G.,Dong, W.,Wang, J.,Fang, Y.,Lin, Y.,Liu, L. Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM. Acta Crystallogr D Struct Biol 2016 72 997 1005 5FFE 27599732 CopM in the Ag-bound form (by soaking) 2015-12-18 2016-09-07 Zhao, S.,Wang, X.,Niu, G.,Dong, W.,Wang, J.,Fang, Y.,Lin, Y.,Liu, L. Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM. Acta Crystallogr D Struct Biol 2016 72 997 1005 5J0A 27262437 Crystal structure of PDZ-binding kinase 2016-03-28 2016-09-07 Dong, C.,Tang, X.,Xie, Y.,Zou, Q.,Yang, X.,Zhou, H. The crystal structure of an inactive dimer of PDZ-binding kinase Biochem.Biophys.Res.Commun. 2016 476 586 593 5DTH Crystal structure of MUPP1 PDZ8 domain from rattus norvegicus 2015-09-18 2016-09-14 Lv, Y.,Li, J.,Zhu, H.,Liu, W. Crystal structure and biochemical characteristics of MUPP1 PDZ8 domain from rattus norregicus To Be Published 0 0 0 0 5EQJ 27582183 Crystal structure of the two-subunit tRNA m1A58 methyltransferase from Saccharomyces cerevisiae 2015-11-13 2016-09-14 Wang, M.,Zhu, Y.,Wang, C.,Fan, X.,Jiang, X.,Ebrahimi, M.,Qiao, Z.,Niu, L.,Teng, M.,Li, X. Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. Sci Rep 2016 6 32562 32562 5GIN 27625427 Crystal structure of box C/D RNP with 12 nt guide regions and 9 nt substrates 2016-06-24 2016-09-14 Yang, Z.,Lin, J.,Ye, K. Box C/D guide RNAs recognize a maximum of 10 nt of substrates Proc.Natl.Acad.Sci.USA 2016 113 10878 10883 5GIO 27625427 Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates 2016-06-24 2016-09-14 Yang, Z.,Lin, J.,Ye, K. Box C/D guide RNAs recognize a maximum of 10 nt of substrates Proc.Natl.Acad.Sci.USA 2016 113 10878 10883 5GIP 27625427 Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates 2016-06-24 2016-09-14 Yang, Z.,Lin, J.,Ye, K. Box C/D guide RNAs recognize a maximum of 10 nt of substrates Proc.Natl.Acad.Sci.USA 2016 113 10878 10883 5HLJ 27572278 Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus 2016-01-15 2016-09-14 Sun, L.F.,Su, Y.T.,Zhao, Y.H.,Fu, Z.Q.,Wu, Y.K. Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus Sci Rep 2016 6 32309 32309 5IXY 27774125 Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one 2016-03-23 2016-09-14 Purkey, H.E.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Gao, Z.,Ge, H.,Hitz, A.,Ho, Q.,Labadie, S.S.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Wei, B.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett. 2016 7 896 901 5B6L 27616292 Structure of Deg protease HhoA from Synechocystis sp. PCC 6803 2016-05-30 2016-09-21 Dong, W.,Wang, J.,Niu, G.,Zhao, S.,Liu, L. Crystal structure of the zinc-bound HhoA protease from Synechocystis sp. PCC 6803 Febs Lett. 2016 590 3435 3442 5DAY The structure of NAP1-Related Protein(NRP1) in Arabidopsis 2015-08-20 2016-09-21 Zhu, Y.,Rong, L.,Yang, Y.,Zhang, C.,Feng, H.Y.,Zheng, L.N.,Shen, W.H.,Ma, J.B.,Dong, A.W. The structure of NAP1-Related Protein(NRP1) in Arabidopsis To Be Published 0 0 0 0 5GND 27616292 Structure of Deg protease HhoA from Synechocystis sp. PCC 6803 2016-07-20 2016-09-21 Dong, W.,Wang, J.,Niu, G.,Zhao, S.,Liu, L. Crystal structure of the zinc-bound HhoA protease from Synechocystis sp. PCC 6803 Febs Lett. 2016 590 3435 3442 5HSI 27292129 Crystal structure of tyrosine decarboxylase at 1.73 Angstroms resolution 2016-01-25 2016-09-21 Zhu, H.,Xu, G.,Zhang, K.,Kong, X.,Han, R.,Zhou, J.,Ni, Y. Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding Sci Rep 2016 6 27779 27779 5DV9 Crystal structure of the Luciferase 2015-09-21 2016-09-28 Su, J.,Li, Z.,Yuan, Z.,Gu, L. Crystal structure of the Luciferase To Be Published 0 0 0 0 5DWV Crystal structure of the Luciferase complexed with substrate analogue 2015-09-23 2016-09-28 Su, J.,Li, Z.,Yuan, Z.,Gu, L. Crystal structure of the Luciferase complexed with substrate analogue To Be Published 0 0 0 0 5EOA 27620379 Crystal structure of OPTN E50K mutant and TBK1 complex 2015-11-10 2016-09-28 Li, F.,Xie, X.,Wang, Y.,Liu, J.,Cheng, X.,Guo, Y.,Gong, Y.,Hu, S.,Pan, L. Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins. Nat Commun 2016 7 12708 12708 5EOF 27620379 Crystal structure of OPTN NTD and TBK1 CTD complex 2015-11-10 2016-09-28 Li, F.,Xie, X.,Wang, Y.,Liu, J.,Cheng, X.,Guo, Y.,Gong, Y.,Hu, S.,Pan, L. Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins. Nat Commun 2016 7 12708 12708 5EP6 27620379 The crystal structure of NAP1 in complex with TBK1 2015-11-11 2016-09-28 Li, F.,Xie, X.,Wang, Y.,Liu, J.,Cheng, X.,Guo, Y.,Gong, Y.,Hu, S.,Pan, L. Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins. Nat Commun 2016 7 12708 12708 5GM1 27613858 Crystal structure of methyltransferase TleD complexed with SAH 2016-07-12 2016-09-28 Yu, F.,Li, M.J.,Xu, C.Y.,Sun, B.,Zhou, H.,Wang, Z.J.,Xu, Q.,Xie, M.Y.,Zuo, G.,Huang, P.,Guo, H.,Wang, Q.S.,He, J.H. Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD Biochem.J. 2016 473 4385 4397 5GM2 27613858 Crystal structure of methyltransferase TleD complexed with SAH and teleocidin A1 2016-07-12 2016-09-28 Yu, F.,Li, M.J.,Xu, C.Y.,Sun, B.,Zhou, H.,Wang, Z.J.,Xu, Q.,Xie, M.Y.,Zuo, G.,Huang, P.,Guo, H.,Wang, Q.S.,He, J.H. Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD Biochem.J. 2016 473 4385 4397 5JR9 27596600 Crystal structure of apo-NeC3PO 2016-05-06 2016-09-28 Zhang, J.,Liu, H.,Yao, Q.,Yu, X.,Chen, Y.,Cui, R.,Wu, B.,Zheng, L.,Zuo, J.,Huang, Z.,Ma, J.,Gan, J. Structural basis for single-stranded RNA recognition and cleavage by C3PO Nucleic Acids Res. 2016 44 9494 9504 5JRC 27596600 Crystal structure of NeC3PO in complex with ssRNA. 2016-05-06 2016-09-28 Zhang, J.,Liu, H.,Yao, Q.,Yu, X.,Chen, Y.,Cui, R.,Wu, B.,Zheng, L.,Zuo, J.,Huang, Z.,Ma, J.,Gan, J. Structural basis for single-stranded RNA recognition and cleavage by C3PO Nucleic Acids Res. 2016 44 9494 9504 5JRE 27596600 Crystal structure of NeC3PO in complex with ssDNA. 2016-05-06 2016-09-28 Zhang, J.,Liu, H.,Yao, Q.,Yu, X.,Chen, Y.,Cui, R.,Wu, B.,Zheng, L.,Zuo, J.,Huang, Z.,Ma, J.,Gan, J. Structural basis for single-stranded RNA recognition and cleavage by C3PO Nucleic Acids Res. 2016 44 9494 9504 5JXB 27565345 PSD-95 extended PDZ3 in complex with SynGAP PBM 2016-05-13 2016-09-28 Zeng, M.,Shang, Y.,Araki, Y.,Guo, T.,Huganir, R.L.,Zhang, M. Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity. Cell 2016 166 1163 0 5JXC 27565345 SynGAP Coiled-coil trimer 2016-05-13 2016-09-28 Zeng, M.,Shang, Y.,Araki, Y.,Guo, T.,Huganir, R.L.,Zhang, M. Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity. Cell 2016 166 1163 0 5T0L 27994750 Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15) 2016-08-16 2016-09-28 Welsch, M.E.,Zhou, J.,Gao, Y.,Yan, Y.,Porter, G.,Agnihotri, G.,Li, Y.,Lu, H.,Chen, Z.,Thomas, S.B. Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. ACS Med Chem Lett 2016 7 1124 1129 5DXX Crystal structure of Dbr2 2015-09-24 2016-10-05 Li, L. The Crystal structure of Dbr2 to be published 0 0 0 0 5DXY Crystal structure of Dbr2 2015-09-24 2016-10-05 Li, L. The Crystal structure of Dbr2 to be published 0 0 0 0 5DY2 Crystal structure of Dbr2 with mutation M27L 2015-09-24 2016-10-05 Li, L. The Crystal structure of Dbr2 to be published 0 0 0 0 5DY3 Crystal structure of Dbr2 2015-09-24 2016-10-05 Li, L. The Crystal structure of Dbr2 to be published 0 0 0 0 5E09 Structural Insight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module 2015-09-28 2016-10-05 Zhang, H.D.,Zhang, H.J. Structural Insight of a Trimodular Halophilic Cellulase with a Family 46 Carbohydrate-Binding Module To Be Published 0 0 0 0 5EIK 27698420 Structure of a Trimeric Intracellular Cation channel from C. elegans in the absence of Ca2+ 2015-10-30 2016-10-05 Yang, H.T.,Hu, M.H.,Guo, J.L.,Ou, X.M.,Cai, T.X.,Liu, Z.F. Pore architecture of TRIC channels and insights into their gating mechanism. Nature 2016 538 537 541 5GS6 27578809 Full-length NS1 structure of Zika virus from 2015 Brazil strain 2016-08-14 2016-10-05 Xu, X.,Song, H.,Qi, J.,Liu, Y.,Wang, H.,Su, C.,Shi, Y.,Gao, G.F. Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure Embo J. 2016 35 2170 2178 5INW 27681598 Structure of reaction loop cleaved lamprey angiotensinogen 2016-03-08 2016-10-05 Wei, H.,Cai, H.,Wu, J.,Wei, Z.,Zhang, F.,Huang, X.,Ma, L.,Feng, L.,Zhang, R.,Wang, Y.,Ragg, H.,Zheng, Y.,Zhou, A. Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism J.Biol.Chem. 2016 291 24900 24911 5J08 27369074 Crystal structure of yeast Ent5 N-terminal domain-native P21 2016-03-28 2016-10-05 Zhang, F.,Song, Y.,Ebrahimi, M.,Niu, L.,Teng, M.K.,Li, X. Structural and functional insight into the N-terminal domain of the clathrin adaptor Ent5 from Saccharomyces cerevisiae Biochem.Biophys.Res.Commun. 2016 477 786 793 5JKG 27618313 The crystal structure of FGFR4 kinase domain in complex with LY2874455 2016-04-26 2016-10-05 Wu, D.,Guo, M.,Philips, M.A.,Qu, L.,Jiang, L.,Li, J.,Chen, X.,Chen, Z.,Chen, L.,Chen, Y. Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 Plos One 2016 11 0 0 5B64 27642159 A novel binding mode of MAGUK GK domain revealed by DLG GK domain in complex with KIF13B MBS domain 2016-05-24 2016-10-12 Zhu, J.,Shang, Y.,Xia, Y.,Zhang, R.,Zhang, M. An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B Structure 2016 24 1876 1885 5DV0 Structure of S. pneumoniae D39 sortase A 2015-09-21 2016-10-12 Deng, X. Structure of S. pneumoniae D39 Sortase A To Be Published 0 0 0 0 5E4L Structure of ligand binding region of uPARAP at pH 5.3 2015-10-06 2016-10-12 Yuan, C.,Huang, M. Crystal structures of uPARAP, a member of mannose receptor family to be published 0 0 0 0 5HBZ 27795409 Structure of EAV NSP11 K170A mutant at 3.10A 2016-01-04 2016-10-12 Zhang, M.,Li, X.,Deng, Z.,Chen, Z.,Liu, Y.,Gao, Y.,Wu, W.,Chen, Z. Structural Biology of the Arterivirus nsp11 Endoribonucleases. J. Virol. 2017 91 0 0 5HJM 27629654 Crystal Structure of Pyrococcus abyssi Trm5a complexed with MTA 2016-01-13 2016-10-12 Wang, C.,Jia, Q.,Chen, R.,Wei, Y.,Li, J.,Ma, J.,Xie, W. Crystal structures of the bifunctional tRNA methyltransferase Trm5a Sci Rep 2016 6 33553 33553 5I40 27219867 BRD9 in complex with Cpd1 (6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one) 2016-02-11 2016-10-12 Crawford, T.D.,Tsui, V.,Flynn, E.M.,Wang, S.,Taylor, A.M.,Cote, A.,Audia, J.E.,Beresini, M.H.,Burdick, D.J.,Cummings, R.,Dakin, L.A.,Duplessis, M.,Good, A.C.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Kiefer, J.R.,Jiang, Y.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G. Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J.Med.Chem. 2016 59 5391 5402 5I7X 27219867 BRD9 in complex with Cpd2 (N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide) 2016-02-18 2016-10-12 Crawford, T.D.,Tsui, V.,Flynn, E.M.,Wang, S.,Taylor, A.M.,Cote, A.,Audia, J.E.,Beresini, M.H.,Burdick, D.J.,Cummings, R.,Dakin, L.A.,Duplessis, M.,Good, A.C.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Kiefer, J.R.,Jiang, Y.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G. Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J.Med.Chem. 2016 59 5391 5402 5I7Y 27219867 BRD9 in complex with Cpd4 ((E)-3-(6-(but-2-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide) 2016-02-18 2016-10-12 Crawford, T.D.,Tsui, V.,Flynn, E.M.,Wang, S.,Taylor, A.M.,Cote, A.,Audia, J.E.,Beresini, M.H.,Burdick, D.J.,Cummings, R.,Dakin, L.A.,Duplessis, M.,Good, A.C.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Kiefer, J.R.,Jiang, Y.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G. Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J.Med.Chem. 2016 59 5391 5402 5I80 27219867 BRD4 in complex with Cpd2 (N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide) 2016-02-18 2016-10-12 Crawford, T.D.,Tsui, V.,Flynn, E.M.,Wang, S.,Taylor, A.M.,Cote, A.,Audia, J.E.,Beresini, M.H.,Burdick, D.J.,Cummings, R.,Dakin, L.A.,Duplessis, M.,Good, A.C.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Kiefer, J.R.,Jiang, Y.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G. Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J.Med.Chem. 2016 59 5391 5402 5I88 27219867 BRD4 in complex with Cpd4 ((E)-3-(6-(but-2-en-1-yl)-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-N,N-dimethylbenzamide) 2016-02-18 2016-10-12 Crawford, T.D.,Tsui, V.,Flynn, E.M.,Wang, S.,Taylor, A.M.,Cote, A.,Audia, J.E.,Beresini, M.H.,Burdick, D.J.,Cummings, R.,Dakin, L.A.,Duplessis, M.,Good, A.C.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Kiefer, J.R.,Jiang, Y.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G. Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J.Med.Chem. 2016 59 5391 5402 5EJL 27650952 MrkH, A novel c-di-GMP dependence transcription regulatory factor. 2015-11-02 2016-10-19 Wang, F.,He, Q.,Su, K.,Gao, F.,Huang, Y.,Lin, Z.,Zhu, D.,Gu, L. The PilZ domain of MrkH represents a novel DNA binding motif Protein Cell 2016 7 766 772 5EOB 27061987 Crystal structure of CMET in complex with novel inhibitor 2015-11-10 2016-10-19 Zhan, Z.,Peng, X.,Liu, Q.,Chen, F.,Ji, Y.,Yao, S.,Xi, Y.,Lin, Y.,Chen, T.,Xu, Y.,Ai, J.,Geng, M.,Duan, W. Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor Eur.J.Med.Chem. 2016 116 239 251 5HW4 27711192 Crystal structure of Escherichia coli 16S rRNA methyltransferase RsmI in complex with AdoMet 2016-01-28 2016-10-19 Zhao, M.,Zhang, H.,Liu, G.,Wang, L.,Wang, J.,Gao, Z.,Dong, Y.,Zhang, L.,Gong, Y. Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI Plos One 2016 11 0 0 5J3R 27710937 Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster 2016-03-31 2016-10-19 Abdalla, M.,Dai, Y.-N.,Chi, C.-B.,Cheng, W.,Cao, D.-D.,Zhou, K.,Ali, W.,Chen, Y.,Zhou, C.-Z. Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster Acta Crystallogr.,Sect.F 2016 72 732 737 5B75 27775714 Crystal structure of MOZ double PHD finger in complex with histone H3 butyrylation at K14 2016-06-05 2016-10-26 Xiong, X.,Panchenko, T.,Yang, S.,Zhao, S.,Yan, P.,Zhang, W.,Xie, W.,Li, Y.,Zhao, Y.,Allis, C.D.,Li, H. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2 Nat.Chem.Biol. 2016 12 1111 1118 5B76 27775714 Crystal structure of MOZ double PHD finger domain in complex with histone H3 crotonylation at K14 2016-06-05 2016-10-26 Xiong, X.,Panchenko, T.,Yang, S.,Zhao, S.,Yan, P.,Zhang, W.,Xie, W.,Li, Y.,Zhao, Y.,Allis, C.D.,Li, H. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2 Nat.Chem.Biol. 2016 12 1111 1118 5B77 27775714 Crystal structrue of MOZ double PHD finger in complex with histone H3 propionylation at K14 2016-06-05 2016-10-26 Xiong, X.,Panchenko, T.,Yang, S.,Zhao, S.,Yan, P.,Zhang, W.,Xie, W.,Li, Y.,Zhao, Y.,Allis, C.D.,Li, H. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2 Nat.Chem.Biol. 2016 12 1111 1118 5B78 27775714 Crystal structure of MOZ double PHD finger mutant-S210D/N235R in complex with histone H3 crotonylation at K14 2016-06-05 2016-10-26 Xiong, X.,Panchenko, T.,Yang, S.,Zhao, S.,Yan, P.,Zhang, W.,Xie, W.,Li, Y.,Zhao, Y.,Allis, C.D.,Li, H. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2 Nat.Chem.Biol. 2016 12 1111 1118 5BT1 27618665 histone chaperone Hif1 playing with histone H2A-H2B dimer 2015-06-02 2016-10-26 Zhang, M.,Liu, H.,Gao, Y.,Zhu, Z.,Chen, Z.,Zheng, P.,Xue, L.,Li, J.,Teng, M.,Niu, L. Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer Structure 2016 24 1810 1820 5DWD Crystal structure of esterase PE8 2015-09-22 2016-10-26 Li, J.,Huang, J. Structure of esterase PE8 To Be Published 0 0 0 0 5EFT Structural Basis for Specific Recognition of ssDNA by SRBSDV P9-1 Octamers 2015-10-26 2016-10-26 Li, X.Y. Structural Basis for Specific Recognition of ssDNA by SRBSDV P9-1 Octamers To Be Published 0 0 0 0 5EIB 27306797 Crystal structure of CPAP PN2-3 C-terminal loop-helix in complex with DARPin-tubulin 2015-10-29 2016-10-26 Zheng, X.,Ramani, A.,Soni, K.,Gottardo, M.,Zheng, S.,Ming Gooi, L.,Li, W.,Feng, S.,Mariappan, A.,Wason, A.,Widlund, P.,Pozniakovsky, A.,Poser, I.,Deng, H.,Ou, G.,Riparbelli, M.,Giuliano, C.,Hyman, A.A.,Sattler, M.,Gopalakrishnan, J.,Li, H. Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length Nat Commun 2016 7 11874 11874 5GYQ 27696819 Putative receptor-binding domain of bat-derived coronavirus HKU9 spike protein 2016-09-23 2016-10-26 Huang, C.,Qi, J.,Lu, G.,Wang, Q.,Yuan, Y.,Wu, Y.,Zhang, Y.,Yan, J.,Gao, G.F. Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: Evolution of Betacoronavirus Receptor Binding Motifs Biochemistry 2016 55 5977 5988 5H1D 27721047 Crystal structure of C-terminal of RhoGDI2 2016-10-08 2016-10-26 Liu, J.,Gao, J.,Li, F.,Ma, R.,Wei, Q.,Wang, A.,Wu, J.,Ruan, K. NMR characterization of weak interactions between RhoGDI2 and fragment screening hits. Biochim. Biophys. Acta 2017 1861 3061 3070 5J9Q 27594449 Crystal structure of the NuA4 core complex 2016-04-11 2016-10-26 Xu, P.,Li, C.,Chen, Z.,Jiang, S.,Fan, S.,Wang, J.,Dai, J.,Zhu, P.,Chen, Z. The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism Mol.Cell 2016 63 965 975 5J9T 27594449 Crystal structure of the NuA4 core complex 2016-04-11 2016-10-26 Xu, P.,Li, C.,Chen, Z.,Jiang, S.,Fan, S.,Wang, J.,Dai, J.,Zhu, P.,Chen, Z. The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism Mol.Cell 2016 63 965 975 5J9U 27594449 Crystal structure of the NuA4 core complex 2016-04-11 2016-10-26 Xu, P.,Li, C.,Chen, Z.,Jiang, S.,Fan, S.,Wang, J.,Dai, J.,Zhu, P.,Chen, Z. The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism Mol.Cell 2016 63 965 975 5J9W 27594449 Crystal structure of the NuA4 core complex 2016-04-11 2016-10-26 Xu, P.,Li, C.,Chen, Z.,Jiang, S.,Fan, S.,Wang, J.,Dai, J.,Zhu, P.,Chen, Z. The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism Mol.Cell 2016 63 965 975 5B73 27477906 Crystal structure of human ZMYND8 PHD-Bromo-PWWP domain 2016-06-03 2016-11-02 Li, N.,Li, Y.,Lv, J.,Zheng, X.,Wen, H.,Shen, H.,Zhu, G.,Chen, T.Y.,Dhar, S.S.,Kan, P.Y.,Wang, Z.,Shiekhattar, R.,Shi, X.,Lan, F.,Chen, K.,Li, W.,Li, H.,Lee, M.G. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes Mol.Cell 2016 63 470 484 5EGG 28540177 Crystal structure of human ubiquitin-conjugating enzyme UBCH5C 2015-10-27 2016-11-02 Wu, F.,Zhu, J.,Li, H.,Zhu, L. Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c Acta Pharm Sin B 2017 7 390 394 5EGN Est816 as an N-Acyl homoserine lactone degrading enzyme 2015-10-27 2016-11-02 Xie, W.,Liu, X.,Cao, L.,Liu, Y. Est816 as an N-Acyl homoserine lactone degrading enzyme To Be Published 0 0 0 0 5EID AKR2A ankyrin repeat domain 2015-10-29 2016-11-02 Pu, H.,Li, H. structure of AKR2A ankyrin repeat domain at 2.0 angstroms resolution To Be Published 0 0 0 0 5EJM 30341164 ThDP-Mn2+ complex of R413A variant of EcMenD soaked with 2-ketoglutarate for 35 min 2015-11-02 2016-11-02 Qin, M.M.,Song, H.G.,Dai, X.,Chen, Y.Z.,Guo, Z.H. Two active site arginines are critical determinants of substrate binding and catalysis in MenD, a thiamine-dependent enzyme in menaquinone biosynthesis. Biochem. J. 2018 0 0 0 5GO3 Crystal structure of a di-nucleotide cyclase Vibrio mutant 2016-07-26 2016-11-02 Ming, Z.H.,Wang, W.,Xie, Y.C.,Chen, Y.C.,Yan, L.M.,Lou, Z.Y. Crystal structure of a di-nucleotide cyclase Vibrio mutant To Be Published 0 0 0 0 5GOO 27777307 Crystal structure of alkaline invertase InvA from Anabaena sp. PCC 7120 complexed with fructose 2016-07-28 2016-11-02 Xie, J.,Cai, K.,Hu, H.X.,Jiang, Y.L.,Yang, F.,Hu, P.F.,Cao, D.D.,Li, W.F.,Chen, Y.,Zhou, C.Z. Structural Analysis of the Catalytic Mechanism and Substrate Specificity of Anabaena Alkaline Invertase InvA Reveals a Novel Glucosidase. J. Biol. Chem. 2016 291 25667 25677 5GOP 27777307 Crystal structure of alkaline invertase InvA from Anabaena sp. PCC 7120 complexed with sucrose 2016-07-28 2016-11-02 Xie, J.,Cai, K.,Hu, H.X.,Jiang, Y.L.,Yang, F.,Hu, P.F.,Cao, D.D.,Li, W.F.,Chen, Y.,Zhou, C.Z. Structural Analysis of the Catalytic Mechanism and Substrate Specificity of Anabaena Alkaline Invertase InvA Reveals a Novel Glucosidase J. Biol. Chem. 2016 291 25667 25677 5GOR 27777307 Crystal structure of alkaline invertase InvA from Anabaena sp. PCC 7120 2016-07-28 2016-11-02 Xie, J.,Cai, K.,Hu, H.X.,Jiang, Y.L.,Yang, F.,Hu, P.F.,Cao, D.D.,Li, W.F.,Chen, Y.,Zhou, C.Z. Structural Analysis of the Catalytic Mechanism and Substrate Specificity of Anabaena Alkaline Invertase InvA Reveals a Novel Glucosidase J. Biol. Chem. 2016 291 25667 25677 5GRJ 27573173 Crystal structure of human PD-L1 with monoclonal antibody avelumab 2016-08-11 2016-11-02 Liu, K.,Tan, S.,Chai, Y.,Chen, D.,Song, H.,Zhang, C.W.,Shi, Y.,Liu, J.,Tan, W.,Lyu, J.,Gao, S.,Yan, J.,Qi, J.,Gao, G.F. Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy. Cell Res. 2017 27 151 153 5JJY 27474439 Crystal structure of SETD2 bound to histone H3.3 K36M peptide 2016-04-25 2016-11-02 Yang, S.,Zheng, X.,Lu, C.,Li, G.M.,Allis, C.D.,Li, H. Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase Genes Dev. 2016 30 1611 1616 5JLB 27474439 Crystal structure of SETD2 bound to histone H3.3 K36I peptide 2016-04-26 2016-11-02 Yang, S.,Zheng, X.,Lu, C.,Li, G.M.,Allis, C.D.,Li, H. Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase Genes Dev. 2016 30 1611 1616 5JLE 27474439 Crystal structure of SETD2 bound to SAH 2016-04-27 2016-11-02 Yang, S.,Zheng, X.,Lu, C.,Li, G.M.,Allis, C.D.,Li, H. Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase Genes Dev. 2016 30 1611 1616 5K8I 27915293 Crystal structure of ZIKV NS3 helicase in complex with ATP and Mn2+ 2016-05-30 2016-11-09 Cao, X.,Li, Y.,Jin, X.,Li, Y.,Guo, F.,Jin, T. Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design. Nucleic Acids Res. 2016 44 10505 10514 5K8L 27915293 Crystal structure of ZIKV NS3 helicase in complex with GTP-gammar S 2016-05-30 2016-11-09 Cao, X.,Li, Y.,Jin, X.,Li, Y.,Guo, F.,Jin, T. Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design. Nucleic Acids Res. 2016 44 10505 10514 5TDH 27498775 The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S 2016-09-19 2016-11-09 Liu, P.,Jia, M.-Z.,Zhou, X.E.,De Waal, P.W.,Dickson, B.M.,Liu, B.,Hou, L.,Yin, Y.-T.,Kang, Y.-Y.,Shi, Y.,Melcher, K.,Xu, H.E.,Jiang, Y. The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer Acta Pharmacol.Sin. 2016 37 1259 1272 5ERI 28580925 MarR Protein from Peptoclostridium difficile DA00132 2015-11-14 2016-11-16 Peng, J.W.,Yuan, H.,Tan, X.S. Crystal structure of the multiple antibiotic resistance regulator MarR from Clostridium difficile. Acta Crystallogr.,Sect.F 2017 73 363 368 5F17 Structure of EAV NSP11 K170A mutant at 3.19A 2015-11-30 2016-11-16 Zhang, M.F.,Chen, Z.Z. Structure of EAV NSP11 K170A mutant at 3.19A To Be Published 0 0 0 0 5H3W 27834729 The structure of the C-terminal of the fibronectin/fibrinogen-binding protein from Streptococcus suis (FBPS) 2016-10-27 2016-11-16 Musyoki, A.M.,Shi, Z.,Xuan, C.,Lu, G.,Qi, J.,Gao, F.,Zheng, B.,Zhang, Q.,Li, Y.,Haywood, J.,Liu, C.,Yan, J.,Shi, Y.,Gao, G.F. Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram-positive bacterium Streptococcus suis Proc. Natl. Acad. Sci. U.S.A. 2016 113 13869 13874 5HEK 27259995 crystal structure of M1.HpyAVI 2016-01-06 2016-11-16 Ma, B.,Ma, J.,Liu, D.,Guo, L.,Chen, H.,Ding, J.,Liu, W.,Zhang, H. Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori Oncotarget 2016 7 40965 40977 5HFJ 27259995 crystal structure of M1.HpyAVI-SAM complex 2016-01-07 2016-11-16 Ma, B.,Ma, J.,Liu, D.,Guo, L.,Chen, H.,Ding, J.,Liu, W.,Zhang, H. Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori Oncotarget 2016 7 40965 40977 5EWT Crystal structure of ExoIII endonuclease from Sulfolobus islandicus 2015-11-21 2016-11-23 Yan, Z.,Yuan, Z.L.,Gu, L.C.,Shen, Y.L. Crystal structure of ExoIII endonuclease from Sulfolobus islandicus To Be Published 0 0 0 0 5GNR the structure of mini-MFN1 K88A in complex with GDP 2016-07-24 2016-11-23 Qi, Y.,Yan, L.,Yu, C.,Lou, Z.,Rao, Z.,Hu, J. BDLP-like folding of Mitofusin 1 To Be Published 0 0 0 0 5GNT BDLP-like folding of Mitofusin 1 2016-07-24 2016-11-23 Yan, L.,Yu, C.,Ming, Z. the structure of mini-MFN1 in complex with GDP To Be Published 0 0 0 0 5GNU the structure of mini-MFN1 apo 2016-07-25 2016-11-23 Qi, Y.,Yan, L.,Yu, C.,Guo, X.,Zhou, X.,Rao, Z.,Lou, Z.,Hu, J. BDLP-like folding of Mitofusin 1 To Be Published 0 0 0 0 5GPD 27811944 Crystal structure of the binding domain of SREBP from fission yeast 2016-08-01 2016-11-23 Gong, X.,Qian, H.,Shao, W.,Li, J.,Wu, J.,Liu, J.J.,Li, W.,Wang, H.W.,Espenshade, P.,Yan, N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization Cell Res. 2016 26 1197 1211 5GR9 27055373 Crystal structure of PXY-TDIF/CLE41 2016-08-08 2016-11-23 Zhang, H.Q.,Lin, X.Y.,Han, Z.F.,Qu, L.J.,Chai, J.J. Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs Cell Res. 2016 26 543 555 5H1K 27881601 Crystal structure of WD40 repeat domains of Gemin5 in complex with 13-nt U4 snRNA fragment 2016-10-10 2016-11-23 Jin, W.,Wang, Y.,Liu, C.P.,Yang, N.,Jin, M.,Cong, Y.,Wang, M.,Xu, R.M. Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5 Genes Dev. 2016 30 2391 2403 5H1M 27881601 Crystal structure of WD40 repeat domains of Gemin5 in complex with M7G 2016-10-10 2016-11-23 Jin, W.,Wang, Y.,Liu, C.P.,Yang, N.,Jin, M.,Cong, Y.,Wang, M.,Xu, R.M. Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5 Genes Dev. 2016 30 2391 2403 5H5N 27217257 The crystal structure of the NS1 (H17N10) RNA-binding domain 2016-11-08 2016-11-23 Zhao, X.,Tefsen, B.,Li, Y.,Qi, J.,Lu, G.,Shi, Y.,Yan, J.,Xiao, H.,Gao, G.F. The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone J.Gen.Virol. 2016 97 1797 1806 5F1I 27511732 MHC with 9-mer peptide 2015-11-30 2016-11-30 Xiao, J.,Xiang, W.,Chai, Y.,Haywood, J.,Qi, J.,Ba, L.,Qi, P.,Wang, M.,Liu, J.,Gao, G.F. Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I J Immunol. 2016 197 2306 2315 5F1N 27511732 MHC complexed to 11mer peptide 2015-11-30 2016-11-30 Xiao, J.,Xiang, W.,Chai, Y.,Haywood, J.,Qi, J.,Ba, L.,Qi, P.,Wang, M.,Liu, J.,Gao, G.F. Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I J Immunol. 2016 197 2306 2315 5GPK 27666591 Crystal structure of Ccp1 mutant 2016-08-03 2016-11-30 Dong, Q.,Yin, F.X.,Gao, F.,Shen, Y.,Zhang, F.,Li, Y.,He, H.,Gonzalez, M.,Yang, J.,Zhang, S.,Su, M.,Chen, Y.H.,Li, F. Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading Mol.Cell 2016 64 79 91 5H4Z 27793683 Crystal structure of S202G mutant of human SYT-5 C2A domain 2016-11-02 2016-11-30 Qiu, X.,Ge, J.,Gao, Y.,Teng, M.,Niu, L. Structural analysis of Ca(2+)-binding pocket of synaptotagmin 5 C2A domain Int. J. Biol. Macromol. 2017 95 946 953 5KPP Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 2016-07-05 2016-11-30 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published 0 0 0 0 5GJS 27910950 Crystal structure of H1 hemagglutinin from A/California/04/2009 in complex with a neutralizing antibody 3E1 2016-07-01 2016-12-07 Wang, W.,Sun, X.,Li, Y.,Su, J.,Ling, Z.,Zhang, T.,Wang, F.,Zhang, H.,Chen, H.,Ding, J.,Sun, B. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses Nat Commun 2016 7 13577 13577 5GNG 27933801 Crystal Structure of BioG from Haemophilus influenzae at 1.26 Angstroms resolution 2016-07-20 2016-12-07 Shi, J.,Cao, X.,Chen, Y.,Cronan, J.E.,Guo, Z. An Atypical alpha / beta-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae Biochemistry 2016 55 6705 6717 5GNS Structures of human Mitofusin 1 provide insight into mitochondrial tethering 2016-07-24 2016-12-07 Qi, Y.,Yan, L.,Yu, C.,Guo, X.,Zhou, X.,Hu, X.,Huang, X.,Rao, Z.,Lou, Z.,Hu, J. Structures of human Mitofusin 1 provide insight into mitochondrial tethering To Be Published 0 0 0 0 5H3B 27933801 Crystal Structure of SeMet-BioG from Haemophilus influenzae at 1.49 Angstroms resolution 2016-10-21 2016-12-07 Shi, J.,Cao, X.,Chen, Y.,Cronan, J.E.,Guo, Z. An Atypical alpha / beta-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae Biochemistry 2016 55 6705 6717 5IE2 27326693 Crystal structure of a plant enzyme 2016-02-24 2016-12-07 Fan, M.,Xiao, Y.,Li, M.,Chang, W. Crystal Structures of Arabidopsis thaliana Oxalyl-CoA Synthetase Essential for Oxalate Degradation Mol Plant 2016 9 1349 1352 5JXR 27919072 Crystal structure of MtISWI 2016-05-13 2016-12-07 Yan, L.,Wang, L.,Tian, Y.,Xia, X.,Chen, Z. Structure and regulation of the chromatin remodeller ISWI Nature 2016 540 466 469 5JXT 27919072 Crystal structure of MtISWI bound with histone H4 tail 2016-05-13 2016-12-07 Yan, L.,Wang, L.,Tian, Y.,Xia, X.,Chen, Z. Structure and regulation of the chromatin remodeller ISWI Nature 2016 540 466 469 5K7X Fully ligated Adenylosuccinate Synthetase from Pyrococcus horikoshii OT3 with GTP, IMP and Hadacidin 2016-05-27 2016-12-07 Xie, Y.,Kishisita, S.,Murayama, K.,Shirouzu, M.,Yokoyama, S. Crystal structure of hypothetical adenylosuccinate synthetase, PH0438 from Pyrococcus horikoshii OT3 To Be Published 0 0 0 0 5B7P 28862845 Structures and functional analysis of periplasmic 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Aeromonas hydrophila 2016-06-08 2016-12-14 Xu, Y.,Wang, L.,Chen, J.,Zhao, J.,Fan, S.,Dong, Y.,Ha, N.C.,Quan, C. Structural and Functional Analyses of Periplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Aeromonas hydrophila. Biochemistry 2017 56 5347 5355 5B7Q 28862845 Structures and functional analysis of periplasmic 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Aeromonas hydrophila 2016-06-08 2016-12-14 Xu, Y.,Wang, L.,Chen, J.,Zhao, J.,Fan, S.,Dong, Y.,Ha, N.C.,Quan, C. Structural and Functional Analyses of Periplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Aeromonas hydrophila. Biochemistry 2017 56 5347 5355 5F3Q Crystal structure of a noncanonical Dicer protein from Entamoeba histolytica 2015-12-03 2016-12-14 Yu, X.,Gan, J.H.,Ma, J.B. Structural and functional study of a noncanonical Dicer protein in Entamoeba histolytica To Be Published 0 0 0 0 5F8P A Novel Inhibitor of the Obesity-Related Protein FTO 2015-12-09 2016-12-14 Chai, J.,Zhou, B.,Liu, W.,Han, Z. Crystal structure of FTO-CHTB To Be Published 0 0 0 0 5F8X The crystal structure of human plasma kallikrein in complex with its peptide inhibitor pkalin-3 2015-12-09 2016-12-14 Xu, M.,Jiang, L.,Xu, P.,Luo, Z.,Andreasen, P.,Huang, M. The Crystal Structure Of Human Plasma Kallikrein In Complex With Its Peptide Inhibitor Pkalin-3 To Be Published 0 0 0 0 5F9P 28103689 Crystal structure study of anthrone oxidase-like protein 2015-12-10 2016-12-14 Pan, G.,Gao, X.,Fan, K.,Liu, J.,Meng, B.,Gao, J.,Wang, B.,Zhang, C.,Han, H.,Ai, G.,Chen, Y.,Wu, D.,Liu, Z.J.,Yang, K. Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis ACS Chem. Biol. 2017 12 142 152 5FB7 28111099 Ligand binding domain 2 of Penicillium marneffei MP1 protein complexed with multiple arachidonic acids 2015-12-14 2016-12-14 Sze, K.H.,Lam, W.H.,Zhang, H.,Ke, Y.H.,Tse, M.K.,Woo, P.C.,Lau, S.K.,Lau, C.C.,Cai, J.P.,Tung, E.T.,Lo, R.K.,Xu, S.,Kao, R.Y.,Hao, Q.,Yuen, K.Y. Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response Cell Chem Biol 2017 24 182 194 5GR8 25475059 Crystal structure of PEPR1-AtPEP1 2016-08-08 2016-12-14 Tang, J.,Han, Z.F.,Sun, Y.D.,Zhang, H.Q.,Gong, X.Q.,Chai, J.J. Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1 Cell Res. 2015 25 110 120 5KPQ Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 2016-07-05 2016-12-14 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published 0 0 0 0 5F5L 28137838 The structure of monooxygenase KstA11 in the biosynthetic pathway of kosinostatin 2015-12-04 2016-12-21 Zhang, Z.,Gong, Y.-K.,Zhou, Q.,Hu, Y.,Ma, H.-M.,Chen, Y.-S.,Igarashi, Y.,Pan, L.,Tang, G.-L. Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade Proc. Natl. Acad. Sci. U.S.A. 2017 114 1554 1559 5F5N 28137838 The structure of monooxygenase KstA11 in complex with NAD and its substrate 2015-12-04 2016-12-21 Zhang, Z.,Gong, Y.-K.,Zhou, Q.,Hu, Y.,Ma, H.-M.,Chen, Y.-S.,Igarashi, Y.,Pan, L.,Tang, G.-L. Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade Proc. Natl. Acad. Sci. U.S.A. 2017 114 1554 1559 5FGL Co-crystal Structure of NicR2_Hsp 2015-12-21 2016-12-21 Zhang, K.,Tang, H.,Wu, G.,Wang, W.,Hu, H.,Xu, P. Co-crystal Structure of NicR2_Hsp To Be Published 0 0 0 0 5FHP SeMet regulator of nicotine degradation 2015-12-22 2016-12-21 Zhang, K.,Tang, H.,Wu, G.,Wang, W.,Hu, H.,Xu, P. Co-crystal Structure of NicR2_Hsp To Be Published 0 0 0 0 5GNI 27958302 The crystal structure of PECAM-1 IgL1-2 trans-homophilic dimer 2016-07-21 2016-12-21 Hu, M.,Zhang, H.,Liu, Q.,Hao, Q. Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion Sci Rep 2016 6 38655 38655 5GOV 27958270 Crystal Structure of MCR-1, a phosphoethanolamine transferase, extracellular domain 2016-07-29 2016-12-21 Hu, M.,Guo, J.,Cheng, Q.,Yang, Z.,Chan, E.W.C.,Chen, S.,Hao, Q. Crystal Structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for Colistin Resistance. Sci Rep 2016 6 38793 38793 5GY3 27917834 The crystal structure of endoglucanase Cel10, a family 8 glycosyl hydrolase from Klebsiella pneumoniae 2016-09-21 2016-12-21 Attigani, A.,Sun, L.,Wang, Q.,Liu, Y.,Bai, D.,Li, S.,Huang, X. The crystal structure of the endoglucanase Cel10, a family 8 glycosyl hydrolase from Klebsiella pneumoniae Acta Crystallogr F Struct Biol 2016 72 870 876 5JRH 27974467 Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A 2016-05-06 2016-12-21 Han, X.,Shen, L.,Wang, Q.,Cen, X.,Wang, J.,Wu, M.,Li, P.,Zhao, W.,Zhang, Y.,Zhao, G. Cyclic AMP Inhibits the Activity and Promotes the Acetylation of Acetyl-CoA Synthetase through Competitive Binding to the ATP/AMP Pocket. J. Biol. Chem. 2017 292 1374 1384 5KCG 27992881 Crystal structure of the aromatic prenyltransferase AtaPT (apo state) from Aspergillus terreus A8-4 2016-06-06 2016-12-21 Chen, R.,Gao, B.,Liu, X.,Ruan, F.,Zhang, Y.,Lou, J.,Feng, K.,Wunsch, C.,Li, S.M.,Dai, J.,Sun, F. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol. 2017 13 226 234 5KCL 27992881 Crystal structure of the aromatic prenyltransferase AtaPT from Aspergillus terreus A8-4 in complex with dimethylallyl S-thiolodiphosphate 2016-06-06 2016-12-21 Chen, R.,Gao, B.,Liu, X.,Ruan, F.,Zhang, Y.,Lou, J.,Feng, K.,Wunsch, C.,Li, S.M.,Dai, J.,Sun, F. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol. 2017 13 226 234 5KCQ 27992881 Crystal structure of the aromatic prenyltransferase AtaPT from Aspergillus terreus A8-4 in complex with geranyl S-thiolodiphosphate 2016-06-06 2016-12-21 Chen, R.,Gao, B.,Liu, X.,Ruan, F.,Zhang, Y.,Lou, J.,Feng, K.,Wunsch, C.,Li, S.M.,Dai, J.,Sun, F. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol. 2017 13 226 234 5KCY 27992881 Crystal structure of the aromatic prenyltransferase AtaPT from Aspergillus terreus A8-4 in complex with geranyl S-thiolodiphosphate and (+)-butyrolactone II 2016-06-07 2016-12-21 Chen, R.,Gao, B.,Liu, X.,Ruan, F.,Zhang, Y.,Lou, J.,Feng, K.,Wunsch, C.,Li, S.M.,Dai, J.,Sun, F. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol. 2017 13 226 234 5KD0 27992881 Crystal structure of the aromatic prenyltransferase AtaPT(E91A) mutant from Aspergillus terreus A8-4 in complex with geranyl S-thiolodiphosphate and (+)-butyrolactone II 2016-06-07 2016-12-21 Chen, R.,Gao, B.,Liu, X.,Ruan, F.,Zhang, Y.,Lou, J.,Feng, K.,Wunsch, C.,Li, S.M.,Dai, J.,Sun, F. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol. 2017 13 226 234 5KD6 27992881 Crystal structure of the aromatic prenyltransferase AtaPT from Aspergillus terreus A8-4 in complex with dimethylallyl S-thiolodiphosphate and (-)-butyrolactone II 2016-06-07 2016-12-21 Chen, R.,Gao, B.,Liu, X.,Ruan, F.,Zhang, Y.,Lou, J.,Feng, K.,Wunsch, C.,Li, S.M.,Dai, J.,Sun, F. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol. 2017 13 226 234 5KDA 27992881 Crystal structure of the aromatic prenyltransferase AtaPT from Aspergillus terreus A8-4 in complex with dimethylallyl S-thiolodiphosphate and genistein 2016-06-07 2016-12-21 Chen, R.,Gao, B.,Liu, X.,Ruan, F.,Zhang, Y.,Lou, J.,Feng, K.,Wunsch, C.,Li, S.M.,Dai, J.,Sun, F. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nat. Chem. Biol. 2017 13 226 234 5KPN Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 2016-07-05 2016-12-21 Cao, R.,Wang, Y.L.,Zhou, J.,Yao, H.P.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published 0 0 0 0 5KPO Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 2016-07-05 2016-12-21 Cao, R.,Wang, Y.L.,Zhou, J.,Yao, H.P.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published 0 0 0 0 5F3O Crystal structure of EhRNaseIII229 from Entamoeba histolytica complexed with Mn2+ 2015-12-03 2016-12-28 Yu, X.,Gan, J.H.,Ma, J.B. Structural and functional study of a noncanonical Dicer protein in Entamoeba histolytica To Be Published 0 0 0 0 5GPE 27989185 Crystal structure of the transcription regulator PbrR691 from Ralstonia metallidurans CH34 in complex with Lead(II) 2016-08-01 2016-12-28 Huang, S.Q.,Liu, X.C.,Wang, D.,Chen, W.Z.,Hu, Q.Y.,Wei, T.B.,Zhou, W.Q.,Gan, J.H.,Chen, H. Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691 Inorg Chem 2016 55 12516 12519 5GRR 28000749 Crystal structure of MCR-1 2016-08-12 2017-01-04 Ma, G.,Zhu, Y.,Yu, Z.,Ahmad, A.,Zhang, H. High resolution crystal structure of the catalytic domain of MCR-1 Sci Rep 2016 6 39540 39540 5GTD 27933791 o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis in Complex with the Acyl-adenylate Intermediate OSB-AMP 2016-08-20 2017-01-04 Chen, Y.,Jiang, Y.,Guo, Z. Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate Biochemistry 2016 55 6685 6695 5GL5 30395931 Sterol 3-beta-glucosyltransferase (ugt51) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c): UDPG complex 2016-07-08 2017-01-11 Chen, L.-Q.,Zhang, Y.,Feng, Y. Structural Dissection of Sterol Glycosyltransferase UGT51 from Saccharomyces cerevisiae for Substrate Specificity. J. Struct. Biol. 2018 0 0 0 5GPR 28053084 Crystal structure of chitinase-h from Ostrinia furnacalis 2016-08-04 2017-01-11 Liu, T.,Chen, L.,Zhou, Y.,Jiang, X.,Duan, Y.,Yang, Q. Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase. J. Biol. Chem. 2017 292 2080 2088 5GQB 28053084 Crystal structure of chitinase-h from O. furnacalis in complex with chitohepatose 2016-08-06 2017-01-11 Liu, T.,Chen, L.,Zhou, Y.,Jiang, X.,Duan, Y.,Yang, Q. Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase. J. Biol. Chem. 2017 292 2080 2088 5H3J 28049725 Crystal structure of Grasp domain of Grasp55 complexed with the Golgin45 C-terminus 2016-10-25 2017-01-11 Zhao, J.,Li, B.,Huang, X.,Morelli, X.,Shi, N. Structural Basis for the Interaction between Golgi Reassembly-stacking Protein GRASP55 and Golgin45 J. Biol. Chem. 2017 292 2956 2965 5HDF 28074848 Hydrolase SeMet-StnA 2016-01-05 2017-01-11 Qian, T.,Wo, J.,Zhang, Y.,Song, Q.,Feng, G.,Luo, R.,Lin, S.,Wu, G.,Chen, H.F. Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode Sci Rep 2017 7 40254 40254 5HDG crystal structure of heat shock factor 1-DBD 2016-01-05 2017-01-11 Feng, H.,Liu, W.,Wang, D.C. HSF1-DBD crystal structure To Be Published 0 0 0 0 5HDP 28074848 Hydrolase StnA mutant - S185A 2016-01-05 2017-01-11 Qian, T.,Wo, J.,Zhang, Y.,Song, Q.,Feng, G.,Luo, R.,Lin, S.,Wu, G.,Chen, H.F. Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode Sci Rep 2017 7 40254 40254 5HQ4 27645700 A Glycoside Hydrolase Family 97 enzyme from Pseudoalteromonas sp. strain K8 2016-01-21 2017-01-11 He, C.,Li, J.,Li, W.,Xue, Y.,Fang, Z.,Fang, W.,Zhang, X.,Wang, X.,Xiao, Y. Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol. 2016 196 426 436 5HQA 27645700 A Glycoside Hydrolase Family 97 enzyme in complex with Acarbose from Pseudoalteromonas sp. strain K8 2016-01-21 2017-01-11 He, C.,Li, J.,Li, W.,Xue, Y.,Fang, Z.,Fang, W.,Zhang, X.,Wang, X.,Xiao, Y. Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol. 2016 196 426 436 5HQC 27645700 A Glycoside Hydrolase Family 97 enzyme R171K variant from Pseudoalteromonas sp. strain K8 2016-01-21 2017-01-11 He, C.,Li, J.,Li, W.,Xue, Y.,Fang, Z.,Fang, W.,Zhang, X.,Wang, X.,Xiao, Y. Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol. 2016 196 426 436 5HYX 27229311 Plant peptide hormone receptor RGFR1 in complex with RGF1 2016-02-02 2017-01-11 Song, W.,Liu, L.,Wang, J.,Wu, Z.,Zhang, H.,Tang, J.,Lin, G.,Wang, Y.,Wen, X.,Li, W.,Han, Z.,Guo, H.,Chai, J. Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth Cell Res. 2016 26 674 685 5E00 29950410 Structure of HLA-A2 P130 2015-09-26 2017-01-18 Zhang, Y.,Wu, Y.,Deng, M.,Xu, D.,Li, X.,Xu, Z.,Hu, J.,Zhang, H.,Liu, K.,Zhao, Y.,Gao, F.,Bi, S.,Gao, G.F.,Zhao, J.,Liu, W.J.,Meng, S. CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. J. Virol. 2018 92 0 0 5GZO 27974667 Structure of neutralizing antibody bound to Zika envelope protein 2016-09-29 2017-01-18 Wang, Q.,Yang, H.,Liu, X.,Dai, L.,Ma, T.,Qi, J.,Wong, G.,Peng, R.,Liu, S.,Li, J.,Li, S.,Song, J.,Liu, J.,He, J.,Yuan, H.,Xiong, Y.,Liao, Y.,Li, J.,Yang, J.,Tong, Z.,Griffin, B.D.,Bi, Y.,Liang, M.,Xu, X.,Qin, C.,Cheng, G.,Zhang, X.,Wang, P.,Qiu, X.,Kobinger, G.,Shi, Y.,Yan, J.,Gao, G.F. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med 2016 8 0 0 5H0J 28049757 The crystal structure of WT Pedobacter heparinus SMUG2 2016-10-04 2017-01-18 Pang, P.,Yang, Y.,Li, J.,Wang, Z.,Cao, W.,Xie, W. SMUG2 DNA glycosylase from Pedobacter heparinus as a new subfamily of the UDG superfamily Biochem. J. 2017 474 923 938 5H0K 28049757 The crystal structure of WT Pedobacter heparinus SMUG2 2016-10-04 2017-01-18 Pang, P.,Yang, Y.,Li, J.,Wang, Z.,Cao, W.,Xie, W. SMUG2 DNA glycosylase from Pedobacter heparinus as a new subfamily of the UDG superfamily Biochem. J. 2017 474 923 938 5H1Y 27928732 Crystal structure of the DDX41 DEAD domain in complex with SO42- and Mg2+ 2016-10-13 2017-01-18 Jiang, Y.,Zhu, Y.,Qiu, W.,Liu, Y.J.,Cheng, G.,Liu, Z.J.,Ouyang, S. Structural and functional analyses of human DDX41 DEAD domain Protein Cell 2017 8 72 76 5H5E 27990635 The crystal structure of the yeast arginine methyltransferase SFM1 complexed with SAH 2016-11-05 2017-01-18 Wang, C.,Zeng, J.,Xie, W. A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1. FEBS Lett. 2017 591 433 441 5H9U Crystal structure of a thermostable methionine adenosyltransferase 2015-12-29 2017-01-18 Feng, Y.,Wang, W. Crystal structure of a thermostable methionine adenosyltransferase To Be Published 0 0 0 0 5HAD 28248291 Crystal structure of intermembrane space region of chloroplast protein ARC6 2015-12-30 2017-01-18 Wang, W.,Li, J.,Sun, Q.,Yu, X.,Zhang, W.,Jia, N.,An, C.,Li, Y.,Dong, Y.,Han, F.,Chang, N.,Liu, X.,Zhu, Z.,Yu, Y.,Fan, S.,Yang, M.,Luo, S.Z.,Gao, H.,Feng, Y. Structural insights into the coordination of plastid division by the ARC6-PDV2 complex Nat Plants 2017 3 17011 17011 5HC0 27328716 Structure of esterase Est22 with p-nitrophenol 2016-01-04 2017-01-18 Huang, J.,Huo, Y.Y.,Ji, R.,Kuang, S.,Ji, C.,Xu, X.W.,Li, J. Structural insights of a hormone sensitive lipase homologue Est22. Sci Rep 2016 6 28550 28550 5HH9 Structure of PvdN from Pseudomonas aeruginosa 2016-01-10 2017-01-18 Xia, H.,Bai, G.,Liu, S.,Li, N.,Xu, S.,Chen, K.,Yao, Q.,Gu, L. Structural and Biochemical Characterization of a Novel L-Cystine Desulfurase involved in the biosynthesis of the major siderophore pyoverdine in Pseudomonas aeruginosa To Be Published 0 0 0 0 5HHA Structure of PvdO from Pseudomonas aeruginosa 2016-01-10 2017-01-18 Yuan, Z.,Shang, G.,Bai, G.,Xia, H.,Gu, L. Crystal structure of Chromophore maturation protein from Pseudomonas aeruginosa To Be Published 0 0 0 0 5HR9 The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5HRB The crystal structure of AsfvPolX:DNA1 binary complex 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5HRD The crystal structure of AsfvPolX:DNA2 binary complex 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5HRE The crystal structure of AsfvPolX:DNA3 binary complex 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5HRF The crystal structure of AsfvPolX: DNA5: dGTP ternary complex 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5HRG The crystal structure of AsfvPolX(D51N mutant):DNA4 binary complex 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5HRH The crystal structure of AsfvPolX(H115F/R127A mutant): 1nt-gap(P) DNA2:dGTP ternary complex 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5HRK The crystal structure of AsfvPolX(H115F mutant): 1nt-gap(P) DNA2:dGTP ternary complex 2016-01-23 2017-01-18 Chen, Y.Q.,Zhang, J.,Gan, J.H. The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published 0 0 0 0 5B6D 28000775 Crystal Structure of cytidine monophosphate hydroxymethylase MilA with CMP 2016-05-26 2017-01-25 Zhao, G.,Chen, C.,Xiong, W.,Gao, T.,Deng, Z.,Wu, G.,He, X. Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis Sci Rep 2016 6 39675 39675 5B6E 28000775 Crystal Structure of cytidine monophosphate hydroxymethylase MilA with hmCMP 2016-05-26 2017-01-25 Zhao, G.,Chen, C.,Xiong, W.,Gao, T.,Deng, Z.,Wu, G.,He, X. Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis Sci Rep 2016 6 39675 39675 5GMO X-ray structure of carbonyl reductase SsCR 2016-07-14 2017-01-25 Shang, Y.P.,Chen, Q.,Kong, X.D.,Zhang, Y.J.,Xu, J.H.,Yu, H.L. Efficient Synthesis of (R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol with a Ketoreductase from Scheffersomyces stipitis CBS 6045 Adv.Synth.Catal. 2017 359 426 431 5GO4 28114303 Truncated mitofusin-1, nucleotide-free 2016-07-26 2017-01-25 Cao, Y.L.,Meng, S.,Chen, Y.,Feng, J.X.,Gu, D.D.,Yu, B.,Li, Y.J.,Yang, J.Y.,Liao, S.,Chan, D.C.,Gao, S. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion Nature 2017 542 372 376 5GOE 28114303 Truncated mitofusin-1, GDP-bound 2016-07-26 2017-01-25 Cao, Y.L.,Meng, S.,Chen, Y.,Feng, J.X.,Gu, D.D.,Yu, B.,Li, Y.J.,Yang, J.Y.,Liao, S.,Chan, D.C.,Gao, S. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion Nature 2017 542 372 376 5GOF 28114303 Truncated mitofusin-1, GTP-bound 2016-07-26 2017-01-25 Cao, Y.L.,Meng, S.,Chen, Y.,Feng, J.X.,Gu, D.D.,Yu, B.,Li, Y.J.,Yang, J.Y.,Liao, S.,Chan, D.C.,Gao, S. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion Nature 2017 542 372 376 5GXU 28103421 Cystal structure of Arabidopsis ATR2 2016-09-20 2017-01-25 Niu, G.,Zhao, S.,Wang, L.,Dong, W.,Liu, L.,He, Y. Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function FEBS J. 2017 284 754 765 5H13 28072869 EED in complex with PRC2 allosteric inhibitor EED396 2016-10-08 2017-01-25 Li, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE 2017 12 0 0 5H14 28072869 EED in complex with an allosteric PRC2 inhibitor EED666 2016-10-08 2017-01-25 Li, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE 2017 12 0 0 5H15 28072869 EED in complex with PRC2 allosteric inhibitor EED709 2016-10-08 2017-01-25 Li, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE 2017 12 0 0 5H17 28072869 EED in complex with PRC2 allosteric inhibitor EED210 2016-10-08 2017-01-25 Li, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE 2017 12 0 0 5H19 28072869 EED in complex with PRC2 allosteric inhibitor EED162 2016-10-08 2017-01-25 Li, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE 2017 12 0 0 5H24 28092155 EED in complex with PRC2 allosteric inhibitor compound 8 2016-10-14 2017-01-25 Huang, Y.,Zhang, J.,Yu, Z.,Zhang, H.,Wang, Y.,Lingel, A.,Qi, W.,Gu, J.,Zhao, K.,Shultz, M.D.,Wang, L.,Fu, X.,Sun, Y.,Zhang, Q.,Jiang, X.,Zhang, J.,Zhang, C.,Li, L.,Zeng, J.,Feng, L.,Zhang, C.,Liu, Y.,Zhang, M.,Zhang, L.,Zhao, M.,Gao, Z.,Liu, X.,Fang, D.,Guo, H.,Mi, Y.,Gabriel, T.,Dillon, M.P.,Atadja, P.,Oyang, C. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy J. Med. Chem. 2017 60 2215 2226 5H25 28092155 EED in complex with PRC2 allosteric inhibitor compound 11 2016-10-14 2017-01-25 Huang, Y.,Zhang, J.,Yu, Z.,Zhang, H.,Wang, Y.,Lingel, A.,Qi, W.,Gu, J.,Zhao, K.,Shultz, M.D.,Wang, L.,Fu, X.,Sun, Y.,Zhang, Q.,Jiang, X.,Zhang, J.,Zhang, C.,Li, L.,Zeng, J.,Feng, L.,Zhang, C.,Liu, Y.,Zhang, M.,Zhang, L.,Zhao, M.,Gao, Z.,Liu, X.,Fang, D.,Guo, H.,Mi, Y.,Gabriel, T.,Dillon, M.P.,Atadja, P.,Oyang, C. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy J. Med. Chem. 2017 60 2215 2226 5HIY 29925659 Crystal structure of PEDV NSP9 Mutant-C59A 2016-01-12 2017-01-25 Zeng, Z.,Deng, F.,Shi, K.,Ye, G.,Wang, G.,Fang, L.,Xiao, S.,Fu, Z.,Peng, G. Dimerization of Coronavirus nsp9 with Diverse Modes Enhances Its Nucleic Acid Binding Affinity. J.Virol. 2018 92 0 0 5HIZ 29925659 The structure of PEDV NSP9 2016-01-12 2017-01-25 Zeng, Z.,Deng, F.,Shi, K.,Ye, G.,Wang, G.,Fang, L.,Xiao, S.,Fu, Z.,Peng, G. Dimerization of Coronavirus nsp9 with Diverse Modes Enhances Its Nucleic Acid Binding Affinity. J.Virol. 2018 92 0 0 5HLG 28086264 Structure of reduced AbfR bound to DNA 2016-01-15 2017-01-25 Liu, G.,Liu, X.,Xu, H.,Liu, X.,Zhou, H.,Huang, Z.,Gan, J.,Chen, H.,Lan, L.,Yang, C.G. Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc. 2017 139 1598 1608 5HLH 28086264 Crystal structure of the overoxidized AbfR bound to DNA 2016-01-15 2017-01-25 Liu, G.,Liu, X.,Xu, H.,Liu, X.,Zhou, H.,Huang, Z.,Gan, J.,Chen, H.,Lan, L.,Yang, C.G. Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc. 2017 139 1598 1608 5HLI 28086264 Structure of Disulfide formed AbfR 2016-01-15 2017-01-25 Liu, G.,Liu, X.,Xu, H.,Liu, X.,Zhou, H.,Huang, Z.,Gan, J.,Chen, H.,Lan, L.,Yang, C.G. Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc. 2017 139 1598 1608 5HQ5 Crystal structure of fragment bound with Brd4 2016-01-21 2017-01-25 Chen, T.T. Crystal structure of fragment bound with Brd4 to be published 0 0 0 0 5HQ6 Crystal structure of fragment bound with Brd4 2016-01-21 2017-01-25 Chen, T.T. Crystal structure of fragment bound with Brd4 to be published 0 0 0 0 5HQ7 Crystal structure of fragment bound with Brd4 2016-01-21 2017-01-25 Chen, T.T. Crystal structure of fragment bound with Brd4 to be published 0 0 0 0 5JNH 28000775 Crystal Structure of cytidine monophosphate hydroxymethylase MilA 2016-04-30 2017-01-25 Zhao, G.,Chen, C.,Xiong, W.,Gao, T.,Deng, Z.,Wu, G.,He, X. Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis Sci Rep 2016 6 39675 39675 5WRQ Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 2016-12-03 2017-01-25 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published 0 0 0 0 5WRY Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 2016-12-04 2017-01-25 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published 0 0 0 0 5WRZ Structure of human PARP1 catalytic domain bound to a phthalazinone inhibitor 2016-12-04 2017-01-25 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a phthalazinone inhibitor To Be Published 0 0 0 0 5WS0 Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor 2016-12-04 2017-01-25 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor To Be Published 0 0 0 0 5WS1 Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor 2016-12-04 2017-01-25 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor To Be Published 0 0 0 0 5WTC Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor 2016-12-11 2017-01-25 Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published 0 0 0 0 5WTX 28053123 Structure of Nop9 2016-12-15 2017-01-25 Wang, B.,Ye, K. Nop9 binds the central pseudoknot region of 18S rRNA Nucleic Acids Res. 2017 45 3559 3567 5WTY 28053123 Structure of Nop9 RNA complex 2016-12-15 2017-01-25 Wang, B.,Ye, K. Nop9 binds the central pseudoknot region of 18S rRNA Nucleic Acids Res. 2017 45 3559 3567 5WWM 28649947 Crystal structure of the TPR domain of Rrp5 2017-01-03 2017-01-25 Sun, Q.,Zhu, X.,Qi, J.,An, W.,Lan, P.,Tan, D.,Chen, R.,Wang, B.,Zheng, S.,Zhang, C.,Chen, X.,Zhang, W.,Chen, J.,Dong, M.Q.,Ye, K. Correction: Molecular architecture of the 90S small subunit pre-ribosome Elife 2017 6 0 0 5WXL 28244370 Crystal structure of the Rrs1 and Rpf2 complex 2017-01-07 2017-01-25 Sun, Q.,Zhu, X.,Qi, J.,An, W.,Lan, P.,Tan, D.,Chen, R.,Wang, B.,Zheng, S.,Zhang, C.,Chen, X.,Zhang, W.,Chen, J.,Dong, M.Q.,Ye, K. Molecular architecture of the 90S small subunit pre-ribosome Elife 2017 6 0 0 5GOM 28114303 Truncated mitofusin-1, transition-like state 2016-07-27 2017-02-01 Cao, Y.L.,Meng, S.,Chen, Y.,Feng, J.X.,Gu, D.D.,Yu, B.,Li, Y.J.,Yang, J.Y.,Liao, S.,Chan, D.C.,Gao, S. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion Nature 2017 542 372 376 5GSA 28135235 EED in complex with an allosteric PRC2 inhibitor 2016-08-15 2017-02-01 Qi, W.,Zhao, K.,Gu, J.,Huang, Y.,Wang, Y.,Zhang, H.,Zhang, M.,Zhang, J.,Yu, Z.,Li, L.,Teng, L.,Chuai, S.,Zhang, C.,Zhao, M.,Chan, H.,Chen, Z.,Fang, D.,Fei, Q.,Feng, L.,Feng, L.,Gao, Y.,Ge, H.,Ge, X.,Li, G.,Lingel, A.,Lin, Y.,Liu, Y.,Luo, F.,Shi, M.,Wang, L.,Wang, Z.,Yu, Y.,Zeng, J.,Zeng, C.,Zhang, L.,Zhang, Q.,Zhou, S.,Oyang, C.,Atadja, P.,Li, E. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Nat. Chem. Biol. 2017 13 381 388 5HSO 28743871 Crystal structure of MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN Rv2887 complex with DNA 2016-01-26 2017-02-01 Gao, Y.R.,Li, D.F.,Fleming, J.,Zhou, Y.F.,Liu, Y.,Deng, J.Y.,Zhou, L.,Zhou, J.,Zhu, G.F.,Zhang, X.E.,Wang, D.C.,Bi, L.J. Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis Sci Rep 2017 7 6471 6471 5HWG Structure of a cysteine hydrolase with a negative substrate 2016-01-29 2017-02-01 Gao, S.,Feng, Y. Structure of a cysteine hydrolase To Be Published 0 0 0 0 5HWH Structure of a cysteine hydrolase with a positive substrate 2016-01-29 2017-02-01 Gao, S.,Feng, Y. Structure of a cysteine hydrolase To Be Published 0 0 0 0 5HXL 29500373 Structure based function annotation of a hypothetical protein MGG_01005 related to the development of rice blast fungus 2016-01-31 2017-02-01 Li, G.,Huang, J.,Yang, J.,He, D.,Wang, C.,Qi, X.,Taylor, I.A.,Liu, J.,Peng, Y.L. Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3. Sci Rep 2018 8 3952 3952 5F3P Crystal structure of a noncanonical Dicer protein from Entamoeba histolytica 2015-12-03 2017-02-08 Yu, X.,Gan, J.H.,Ma, J.B. Structural and functional study of a noncanonical Dicer protein in Entamoeba histolytica To Be Published 0 0 0 0 5GKD 28154171 Structure of PL6 family alginate lyase AlyGC 2016-07-04 2017-02-08 Xu, F.,Dong, F.,Wang, P.,Cao, H.Y.,Li, C.Y.,Li, P.Y.,Pang, X.H.,Zhang, Y.Z.,Chen, X.L. Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6 J. Biol. Chem. 2017 292 4457 4468 5GKQ 28154171 Structure of PL6 family alginate lyase AlyGC mutant-R241A 2016-07-05 2017-02-08 Xu, F.,Dong, F.,Wang, P.,Cao, H.Y.,Li, C.Y.,Li, P.Y.,Pang, X.H.,Zhang, Y.Z.,Chen, X.L. Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6 J. Biol. Chem. 2017 292 4457 4468 5GSK 27998930 Crystal structure of duplex DNA3 in complex with Hg(II) and Sr(II) 2016-08-16 2017-02-08 Liu, H.H.,Cai, C.,Haruehanroengra, P.,Yao, Q.Q.,Chen, Y.Q.,Yang, C.,Luo, Q.,Wu, B.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H. Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex Nucleic Acids Res. 2017 45 2910 2918 5GT2 28109884 Crystal Structure and Biochemical Features of dye-decolorizing peroxidase YfeX from Escherichia coli O157 2016-08-18 2017-02-08 Liu, X.,Yuan, Z.,Wang, J.,Cui, Y.,Liu, S.,Ma, Y.,Gu, L.,Xu, S. Crystal structure and biochemical features of dye-decolorizing peroxidase YfeX from Escherichia coli O157 Asp(143) and Arg(232) play divergent roles toward different substrates Biochem. Biophys. Res. Commun. 2017 484 40 44 5HS5 Crystal structure of Staphylococcus aureus SarX 2016-01-25 2017-02-08 Zhang, F.,Song, Y.,Li, X.,Teng, M.K. Crystal structure of Staphylococcus aureus SarX To Be Published 0 0 0 0 5HXD 27894248 Crystal structure of murein-tripeptide amidase MpaA from Escherichia coli O157 2016-01-30 2017-02-08 Ma, Y.,Bai, G.,Cui, Y.,Zhao, J.,Yuan, Z.,Liu, X. Crystal Structure of Murein-Tripeptide Amidase MpaA from Escherichia coli O157 at 2.6 angstrom Resolution Protein Pept.Lett. 2017 24 181 187 5WTK 28086085 Crystal structure of RNP complex 2016-12-13 2017-02-08 Liu, L.,Li, X.,Wang, J.,Wang, M.,Chen, P.,Yin, M.,Li, J.,Sheng, G.,Wang, Y. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities Cell 2017 168 121 0 5GWD 28188295 Structure of Myroilysin 2016-09-10 2017-02-15 Xu, D.,Zhou, J.,Lou, X.,He, J.,Ran, T.,Wang, W. Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. J. Biol. Chem. 2017 292 5195 5206 5H9Y 28787048 Crystal structure of GH family 64 laminaripentaose-producing beta-1,3-glucanase from Paenibacillus barengoltzii complexed with laminarihexaose. 2015-12-29 2017-02-15 Qin, Z.,Yang, D.,You, X.,Liu, Y.,Hu, S.,Yan, Q.,Yang, S.,Jiang, Z. The recognition mechanism of triple-helical beta-1,3-glucan by a beta-1,3-glucanase Chem. Commun. (Camb.) 2017 53 9368 9371 5HXF Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir 2016-01-30 2017-02-15 Li, B.,Yue, Y.,Zhang, Y.,Yuan, Z.,Liu, Y.,Li, P.,Song, N.,Li, Z.,Gu, L.,Qin, L. Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir To Be Published 0 0 0 0 5HXG STM1697-FlhD complex 2016-01-30 2017-02-15 Li, B.,Yue, Y.,Yuan, Z.,Zhang, F.,Liu, Y.,Li, P.,Song, N.,Li, Z.,Gu, L.,Qin, L. Crystal structure of STM1697-FlhD complex To Be Published 0 0 0 0 5WT9 28165004 Complex structure of PD-1 and nivolumab-Fab 2016-12-10 2017-02-15 Tan, S.,Zhang, H.,Chai, Y.,Song, H.,Tong, Z.,Wang, Q.,Qi, J.,Wong, G.,Zhu, X.,Liu, W.J.,Gao, S.,Wang, Z.,Shi, Y.,Yang, F.,Gao, G.F.,Yan, J. An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nat Commun 2017 8 14369 14369 5JCD 27238968 Crystal structure of OsCEBiP 2016-04-15 2017-02-22 Liu, S.M.,Wang, J.Z.,Han, Z.,Gong, X.,Zhang, H.,Chai, J.J. Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP Structure 2016 24 1192 1200 5JDK 28223353 Crystal structure of the DNA binding domain of Sap1 in fission yeast S.pombe 2016-04-17 2017-02-22 Guan, L.,He, P.,Yang, F.,Zhang, Y.,Hu, Y.,Ding, J.,Hua, Y.,Zhang, Y.,Ye, Q.,Hu, J.,Wang, T.,Jin, C.,Kong, D. Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 2017 292 6056 6075 5T2P 28205569 Hepatitis B virus core protein Y132A mutant in complex with sulfamoylbenzamide (SBA_R01) 2016-08-24 2017-02-22 Zhou, Z.,Hu, T.,Zhou, X.,Wildum, S.,Garcia-Alcalde, F.,Xu, Z.,Wu, D.,Mao, Y.,Tian, X.,Zhou, Y.,Shen, F.,Zhang, Z.,Tang, G.,Najera, I.,Yang, G.,Shen, H.C.,Young, J.A.,Qin, N. Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep 2017 7 42374 42374 5TUC 28168758 Crystal Structure of the Sus TBC1D15 GAP Domain 2016-11-05 2017-02-22 Chen, Y.N.,Gu, X.,Zhou, X.E.,Wang, W.,Cheng, D.,Ge, Y.,Ye, F.,Xu, H.E.,Lv, Z. Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci. 2017 26 834 846 5TUC 28168758 Crystal Structure of the Sus TBC1D15 GAP Domain 2016-11-05 2017-02-22 Chen, Y.N.,Gu, X.,Zhou, X.E.,Wang, W.,Cheng, D.,Ge, Y.,Ye, F.,Xu, H.E.,Lv, Z. Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci. 2017 26 834 846 5WRE 28205569 Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01) 2016-12-01 2017-02-22 Zhou, Z.,Hu, T.,Zhou, X.,Wildum, S.,Garcia-Alcalde, F.,Xu, Z.,Wu, D.,Mao, Y.,Tian, X.,Zhou, Y.,Shen, F.,Zhang, Z.,Tang, G.,Najera, I.,Yang, G.,Shen, H.C.,Young, J.A.,Qin, N. Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep 2017 7 42374 42374 5WTW 28205569 Hepatitis B virus core protein Y132A mutant in P 41 21 2 Space Group 2016-12-15 2017-02-22 Zhou, Z.,Hu, T.,Zhou, X.,Wildum, S.,Garcia-Alcalde, F.,Xu, Z.,Wu, D.,Mao, Y.,Tian, X.,Zhou, Y.,Shen, F.,Zhang, Z.,Tang, G.,Najera, I.,Yang, G.,Shen, H.C.,Young, J.A.,Qin, N. Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep 2017 7 42374 42374 5GTB 28248291 crystal structure of intermembrane space region of the ARC6-PDV2 complex 2016-08-19 2017-03-01 Wang, W.,Li, J.,Sun, Q.,Yu, X.,Zhang, W.,Jia, N.,An, C.,Li, Y.,Dong, Y.,Han, F.,Chang, N.,Liu, X.,Zhu, Z.,Yu, Y.,Fan, S.,Yang, M.,Luo, S.Z.,Gao, H.,Feng, Y. Structural insights into the coordination of plastid division by the ARC6-PDV2 complex Nat Plants 2017 3 17011 17011 5GVV 28246170 Crystal structure of the glycosyltransferase GlyE in Streptococcus pneumoniae TIGR4 2016-09-07 2017-03-01 Jiang, Y.L.,Jin, H.,Yang, H.B.,Zhao, R.L.,Wang, S.,Chen, Y.,Zhou, C.Z. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. J. Biol. Chem. 2017 292 6213 6224 5GVW 28246170 Crystal structure of the apo-form glycosyltransferase GlyE in Streptococcus pneumoniae TIGR4 2016-09-07 2017-03-01 Jiang, Y.L.,Jin, H.,Yang, H.B.,Zhao, R.L.,Wang, S.,Chen, Y.,Zhou, C.Z. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. J. Biol. Chem. 2017 292 6213 6224 5I95 28193778 Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid 2016-02-19 2017-03-01 Yen, K.,Travins, J.,Wang, F.,David, M.D.,Artin, E.,Straley, K.,Padyana, A.,Gross, S.,DeLaBarre, B.,Tobin, E.,Chen, Y.,Nagaraja, R.,Choe, S.,Jin, L.,Konteatis, Z.,Cianchetta, G.,Saunders, J.O.,Salituro, F.G.,Quivoron, C.,Opolon, P.,Bawa, O.,Saada, V.,Paci, A.,Broutin, S.,Bernard, O.A.,de Botton, S.,Marteyn, B.S.,Pilichowska, M.,Xu, Y.,Fang, C.,Jiang, F.,Wei, W.,Jin, S.,Silverman, L.,Liu, W.,Yang, H.,Dang, L.,Dorsch, M.,Penard-Lacronique, V.,Biller, S.A.,Su, S.M. AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov 2017 7 478 493 5GGZ 27933959 Crystal structure of novel inhibitor bound with Hsp90 2016-06-16 2017-03-08 Jiang, F.,Wang, H.J.,Jin, Y.H.,Zhang, Q.,Wang, Z.H.,Jia, J.M.,Liu, F.,Wang, L.,Bao, Q.C.,Li, D.D.,You, Q.D.,Xu, X.L. Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90 J. Med. Chem. 2016 59 10498 10519 5GMV 27757847 LC3B-FUNDC1 complex 2016-07-17 2017-03-08 Lv, M.,Wang, C.,Li, F.,Peng, J.,Wen, B.,Gong, Q.,Shi, Y.,Tang, Y. Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy Protein Cell 2017 8 25 38 5H0M 28211904 Crystal structure of deep-sea thermophilic bacteriophage GVE2 HNH endonuclease with zinc ion 2016-10-05 2017-03-08 Zhang, L.K.,Xu, D.D.,Huang, Y.C.,Zhu, X.Y.,Rui, M.W.,Wan, T.,Zheng, X.,Shen, Y.L.,Chen, X.D.,Ma, K.S.,Gong, Y. Structural and functional characterization of deep-sea thermophilic bacteriophage GVE2 HNH endonuclease Sci Rep 2017 7 42542 42542 5H6W Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain F598H mutant 2016-11-15 2017-03-08 Yuan, H. Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain F598H mutant To Be Published 0 0 0 0 5I96 28193778 Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with AG-221 (Enasidenib) Inhibitor. 2016-02-19 2017-03-08 Yen, K.,Travins, J.,Wang, F.,David, M.D.,Artin, E.,Straley, K.,Padyana, A.,Gross, S.,DeLaBarre, B.,Tobin, E.,Chen, Y.,Nagaraja, R.,Choe, S.,Jin, L.,Konteatis, Z.,Cianchetta, G.,Saunders, J.O.,Salituro, F.G.,Quivoron, C.,Opolon, P.,Bawa, O.,Saada, V.,Paci, A.,Broutin, S.,Bernard, O.A.,de Botton, S.,Marteyn, B.S.,Pilichowska, M.,Xu, Y.,Fang, C.,Jiang, F.,Wei, W.,Jin, S.,Silverman, L.,Liu, W.,Yang, H.,Dang, L.,Dorsch, M.,Penard-Lacronique, V.,Biller, S.A.,Su, S.M. AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov 2017 7 478 493 5IAW 28186695 Novel natural FXR modulator with a unique binding mode 2016-02-22 2017-03-08 Zheng, W.,Lu, Y.,Lin, S.,Wang, R.,Qiu, L.,Zhu, Y.,Yao, B.,Guo, F.,Jin, S.,Jin, L.,Li, Y. A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly Chembiochem 2017 18 721 725 5ICK 28186695 A unique binding model of FXR LBD with feroline 2016-02-23 2017-03-08 Zheng, W.,Lu, Y.,Lin, S.,Wang, R.,Qiu, L.,Zhu, Y.,Yao, B.,Guo, F.,Jin, S.,Jin, L.,Li, Y. A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly Chembiochem 2017 18 721 725 5IL9 29180814 Crystal structure of Deg9 2016-03-04 2017-03-08 Ouyang, M.,Li, X.,Zhao, S.,Pu, H.,Shen, J.,Adam, Z.,Clausen, T.,Zhang, L. The crystal structure of Deg9 reveals a novel octameric-type HtrA protease Nat Plants 2017 3 973 982 5ILA 29180814 Deg9 protease domain 2016-03-04 2017-03-08 Ouyang, M.,Li, X.,Zhao, S.,Pu, H.,Shen, J.,Adam, Z.,Clausen, T.,Zhang, L. The crystal structure of Deg9 reveals a novel octameric-type HtrA protease Nat Plants 2017 3 973 982 5ILB 29180814 Crystal structure of protease domain of Deg2 linked with the PDZ domain of Deg9 2016-03-04 2017-03-08 Ouyang, M.,Li, X.,Zhao, S.,Pu, H.,Shen, J.,Adam, Z.,Clausen, T.,Zhang, L. The crystal structure of Deg9 reveals a novel octameric-type HtrA protease Nat Plants 2017 3 973 982 5J9S 28241141 ENL YEATS in complex with histone H3 acetylation at K27 2016-04-11 2017-03-08 Wan, L.,Wen, H.,Li, Y.,Lyu, J.,Xi, Y.,Hoshii, T.,Joseph, J.K.,Wang, X.,Loh, Y.E.,Erb, M.A.,Souza, A.L.,Bradner, J.E.,Shen, L.,Li, W.,Li, H.,Allis, C.D.,Armstrong, S.A.,Shi, X. ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia Nature 2017 543 265 269 5TOU 28188780 STRUCTURE OF C-PHYCOCYANIN FROM ARCTIC PSEUDANABAENA SP. LW0831 2016-10-18 2017-03-08 Su, H.N.,Wang, Q.M.,Li, C.Y.,Li, K.,Luo, W.,Chen, B.,Zhang, X.Y.,Qin, Q.L.,Zhou, B.C.,Chen, X.L.,Zhang, Y.Z.,Xie, B.B. Structural insights into the cold adaptation of the photosynthetic pigment-protein C-phycocyanin from an Arctic cyanobacterium Biochim. Biophys. Acta 2017 1858 325 335 5WZ2 28254839 Crystal structure of Zika virus NS5 methyltransferase bound to SAM and RNA analogue (m7GpppA) 2017-01-16 2017-03-08 Duan, W.,Song, H.,Wang, H.,Chai, Y.,Su, C.,Qi, J.,Shi, Y.,Gao, G.F. The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J. 2017 36 919 933 5WZ3 28254839 Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase(RdRP) 2017-01-16 2017-03-08 Duan, W.,Song, H.,Wang, H.,Chai, Y.,Su, C.,Qi, J.,Shi, Y.,Gao, G.F. The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J. 2017 36 919 933 5JP9 28000775 Crystal Structure of cytidine monophosphate hydroxymethylase MilA with dCMP 2016-05-03 2017-03-15 Zhao, G.,Chen, C.,Xiong, W.,Gao, T.,Deng, Z.,Wu, G.,He, X. Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis Sci Rep 2016 6 39675 39675 5X6G 26304548 Crystal Structure of SMAD5-MH1/palindromic SBE DNA complex 2017-02-21 2017-03-15 Chai, N.,Li, W.X.,Wang, J.,Wang, Z.X.,Yang, S.M.,Wu, J.W. Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. Nucleic Acids Res. 2015 43 9051 9064 5X6H 26304548 Crystal Structure of SMAD5-MH1/GC-BRE DNA complex 2017-02-22 2017-03-15 Chai, N.,Li, W.X.,Wang, J.,Wang, Z.X.,Yang, S.M.,Wu, J.W. Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. Nucleic Acids Res. 2015 43 9051 9064 5X6M 26304548 Crystal Structure of SMAD5-MH1 in complex with a composite DNA sequence 2017-02-22 2017-03-15 Chai, N.,Li, W.X.,Wang, J.,Wang, Z.X.,Yang, S.M.,Wu, J.W. Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. Nucleic Acids Res. 2015 43 9051 9064 5HZ1 Plant peptide hormone receptor RGFR1 in complex with RGF3 2016-02-02 2017-03-22 Song, W.,Han, Z.,Chai, J. Plant Receptor To Be Published 0 0 0 0 5HZ3 Plant peptide hormone receptor RGFR1 in complex with RGFR5 2016-02-02 2017-03-22 Song, W.,Han, Z.,Chai, J. Plant Receptor To Be Published 0 0 0 0 5IHW The crystal structure of SdrE from staphylococcus aureus 2016-02-29 2017-03-22 Zhang, S.,Wei, J.,Wu, S.,Zhang, X.,Luo, M.,Wang, D. The crystal structure of SdrE from staphylococcus aureus To Be Published 0 0 0 0 5JWA 28195463 the structure of malaria PfNDH2 2016-05-11 2017-03-22 Yang, Y.,Yu, Y.,Li, X.,Li, J.,Wu, Y.,Yu, J.,Ge, J.,Huang, Z.,Jiang, L.,Rao, Y.,Yang, M. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem. 2017 60 1994 2005 5JWC 28195463 Structure of NDH2 from plasmodium falciparum in complex with RYL-552 2016-05-12 2017-03-22 Yang, Y.,Yu, Y.,Li, X.,Li, J.,Wu, Y.,Yu, J.,Ge, J.,Huang, Z.,Jiang, L.,Rao, Y.,Yang, M. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem. 2017 60 1994 2005 5X3P 28274878 Crystal structure of the UBX domain of human UBXD7 2017-02-06 2017-03-22 Li, Z.H.,Wang, Y.,Xu, M.,Jiang, T. Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase Biochem. Biophys. Res. Commun. 2017 486 94 100 5GK9 28334966 Crystal structure of human HBO1 in complex with BRPF2 2016-07-04 2017-03-29 Tao, Y.,Zhong, C.,Zhu, J.,Xu, S.,Ding, J. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2. Nucleic Acids Res. 2017 45 5707 5719 5IW3 anti-CD20 monoclonal antibody Fc fragment 2016-03-21 2017-03-29 Tang, C.,Chen, Z. Structure of anti-CD20 monoclonal antibody Fc fragment at 2.05 Angstroms resolution To Be Published 0 0 0 0 5IWB Crystal structure of design pentatricopeptide repeat complex with MORF protein 2016-03-22 2017-03-29 Yan, J.,Zhang, Q.,Guan, Z.,Zou, T.,Yin, P. Structural basis for designer pentatricopeptide repeat proteins interaction with MORF protein To be published 0 0 0 0 5IWW 28394309 Crystal structure of RNA editing factor of designer PLS-type PPR/9R protein in complex with MORF9/RIP9 2016-03-23 2017-03-29 Yan, J.,Zhang, Q.,Guan, Z.,Wang, Q.,Li, L.,Ruan, F.,Lin, R.,Zou, T.,Yin, P. MORF9 increases the RNA-binding activity of PLS-type pentatricopeptide repeat protein in plastid RNA editing Nat Plants 2017 3 17037 17037 5IWX 29335298 Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Bacillus subtitis 2016-03-23 2017-03-29 Liu, Z.C.,Jin, Y.,Liu, W.F.,Tao, Y.,Wang, G.G. Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly among IspD/IspE/IspF enzymes in the MEP pathway. Biosci. Rep. 2018 0 0 0 5IWY 29335298 Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Bacillus subtitis complexed with CMP and Mg2+ 2016-03-23 2017-03-29 Liu, Z.C.,Jin, Y.,Liu, W.F.,Tao, Y.,Wang, G.G. Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly among IspD/IspE/IspF enzymes in the MEP pathway. Biosci. Rep. 2018 0 0 0 5IWZ Synaptonemal complex protein 2016-03-23 2017-03-29 Feng, J.,Fu, S.,Cao, X.,Wu, H.,Lu, J.,Zeng, M.,Liu, L.,Yang, X.,Shen, Y. Structure of synaptonemal complexes protein at 2.6 angstroms resolution To Be Published 0 0 0 0 5JWB 28195463 Structure of NDH2 from plasmodium falciparum in complex with NADH 2016-05-12 2017-03-29 Yang, Y.,Yu, Y.,Li, X.,Li, J.,Wu, Y.,Yu, J.,Ge, J.,Huang, Z.,Jiang, L.,Rao, Y.,Yang, M. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem. 2017 60 1994 2005 5X7F Structure of a O-methyltransferase from Mycobacterium tuberculosis at 2.0 resolution 2017-02-25 2017-03-29 Yan, Q.,Jiang, D. Structure of a O-methyltransferase from Mycobacterium tuberculosis at 2.0 resolution To Be Published 0 0 0 0 5HZ0 Plant peptide hormone receptor RGFR1 in complex with RGF2 2016-02-02 2017-04-05 Song, W.,Han, Z.,Chai, J. Plant Receptor To Be Published 0 0 0 0 5I8I 29263142 Crystal Structure of the K. lactis Urea Amidolyase 2016-02-19 2017-04-05 Zhao, J.,Zhu, L.,Fan, C.,Wu, Y.,Xiang, S. Structure and function of urea amidolyase. Biosci. Rep. 2018 38 0 0 5J3J Crystal Structure of human DPP-IV in complex with HL1 2016-03-31 2017-04-05 Wu, F.,Li, H.,Zhao, Z.,Zhu, L.,Xu, H.,Li, S. Crystal Structure of human DPP-IV in complex with HL1 To Be Published 0 0 0 0 5J5K CRYSTAL STRUCTURE OF AFMP4P IN COMPLEX WITH PALMITIC ACID 2016-04-03 2017-04-05 Zhang, H.,Hao, Q.,Lam, W.H. A Novel Class Of Virulence Factors In Penicillium Marneffei And Aspergillus Fumigatus Enhances Intracellular Survival In Monocytes By Arachidonic Acid Binding To Be Published 0 0 0 0 5J5L CRYSTAL STRUCTURE OF AFMP4P IN COMPLEX WITH ARACHIDONIC ACID 2016-04-03 2017-04-05 Zhang, H.,Hao, Q. A Novel Class Of Virulence Factors In Penicillium Marneffei And Aspergillus Fumigatus Enhances Intracellular Survival In Monocytes By Arachidonic Acid Binding To Be Published 0 0 0 0 5WTR Crystal structure of a prokaryotic TRIC channel in 0.5 M KCl 2016-12-14 2017-04-05 Ou, X.M.,Guo, J.L.,Wang, L.F.,Yang, H.T.,Liu, X.Y.,Sun, J.Y.,Liu, Z.F. Ion and water binding sites inside an occluded hourglass pore of a TRIC channel BMC BIOL. 2017 0 0 0 5X5Y 28394325 A membrane protein complex 2017-02-18 2017-04-05 Luo, Q.,Yang, X.,Yu, S.,Shi, H.,Wang, K.,Xiao, L.,Zhu, G.,Sun, C.,Li, T.,Li, D.,Zhang, X.,Zhou, M.,Huang, Y. Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG Nat. Struct. Mol. Biol. 2017 24 469 474 5GNX 28189793 The E171Q mutant structure of Bgl6 2016-07-25 2017-04-12 Pang, P.,Cao, L.C.,Liu, Y.H.,Xie, W.,Wang, Z. Structures of a glucose-tolerant beta-glucosidase provide insights into its mechanism. J. Struct. Biol. 2017 198 154 162 5GNY 28189793 The structure of WT Bgl6 2016-07-25 2017-04-12 Pang, P.,Cao, L.C.,Liu, Y.H.,Xie, W.,Wang, Z. Structures of a glucose-tolerant beta-glucosidase provide insights into its mechanism. J. Struct. Biol. 2017 198 154 162 5GNZ 28189793 The M3 mutant structure of Bgl6 2016-07-25 2017-04-12 Pang, P.,Cao, L.C.,Liu, Y.H.,Xie, W.,Wang, Z. Structures of a glucose-tolerant beta-glucosidase provide insights into its mechanism. J. Struct. Biol. 2017 198 154 162 5J4U Crystal structure of a glutathione S-transferase PtGSTU30 from Populus trichocarpa in complex with GSH 2016-04-01 2017-04-12 Yang, Q.,Han, X.,Gu, J.,Liu, Y.,Yang, M.,Zeng, Q. Functional and Structural Profiles of GST Gene Family from Three Populus Species Revealed the Sequence-function Decoupling of Orthologous Genes To Be Published 0 0 0 0 5JDR 28280600 Structure of PD-L1 2016-04-17 2017-04-12 Zhang, F.,Wei, H.,Wang, X.,Bai, Y.,Wang, P.,Wu, J.,Jiang, X.,Wang, Y.,Cai, H.,Xu, T.,Zhou, A. Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade. Cell Discov 2017 3 17004 17004 5WUU 28347667 Complex structure of the first bromodomain of BRD4 with an inhibitor that containing a 2H-chromen-2-one ring 2016-12-21 2017-04-12 Sun, Z.,Zhang, H.,Chen, Z.,Xie, Y.,Jiang, H.,Chen, L.,Ding, H.,Zhang, Y.,Jiang, H.,Zheng, M.,Luo, C. Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays. Bioorg. Med. Chem. Lett. 2017 27 2003 2009 5WYG 28351618 The crystal structure of the apo form of Mtb MazF 2017-01-13 2017-04-12 Chen, R.,Tu, J.,Liu, Z.,Meng, F.,Ma, P.,Ding, Z.,Yang, C.,Chen, L.,Deng, X.,Xie, W. Structure of the MazF-mt9 toxin, a tRNA-specific endonuclease from Mycobacterium tuberculosis Biochem. Biophys. Res. Commun. 2017 486 804 810 5GUJ 28386108 Crystal structure of the Bacillus subtilis DnaG RNA Polymerase Domain, natural degradation of full length DnaG 2016-08-29 2017-04-19 Zhou, Y.,Luo, H.,Liu, Z.,Yang, M.,Pang, X.,Sun, F.,Wang, G. Structural Insight into the Specific DNA Template Binding to DnaG primase in Bacteria Sci Rep 2017 7 659 659 5GVA 28381552 WD40 domain of human AND-1 2016-09-04 2017-04-19 Guan, C.,Li, J.,Sun, D.,Liu, Y.,Liang, H. The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome J. Biol. Chem. 2017 292 9627 9636 5GVB 28381552 SepB domain of human AND-1 2016-09-05 2017-04-19 Guan, C.,Li, J.,Sun, D.,Liu, Y.,Liang, H. The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome. J. Biol. Chem. 2017 292 9627 9636 5GZB 28368398 Crystal Structure of Transcription Factor TEAD4 in Complex with M-CAT DNA 2016-09-28 2017-04-19 Shi, Z.B.,He, F.,Chen, M.,Hua, L.,Wang, W.,Jiao, S.,Zhou, Z.C. DNA-binding mechanism of the Hippo pathway transcription factor TEAD4 Oncogene 2017 36 4362 4369 5K04 28380339 The NatB Acetyltransferase Complex Bound To CoA and MES 2016-05-17 2017-04-19 Hong, H.,Cai, Y.,Zhang, S.,Ding, H.,Wang, H.,Han, A. Molecular Basis of Substrate Specific Acetylation by N-Terminal Acetyltransferase NatB Structure 2017 25 641 0 5WXN 28368277 Structure of the LKB1 and 14-3-3 complex 2017-01-08 2017-04-19 Lu, Y.,Ding, S.,Zhou, R.,Wu, J. Structure of the complex of phosphorylated liver kinase B1 and 14-3-3 zeta Acta Crystallogr F Struct Biol 2017 73 196 201 5X3E 28393873 kinesin 6 2017-02-04 2017-04-19 Guan, R.,Zhang, L.,Su, Q.P.,Mickolajczyk, K.J.,Chen, G.Y.,Hancock, W.O.,Sun, Y.,Zhao, Y.,Chen, Z. Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin Nat Commun 2017 8 14951 14951 5GSR 27903740 Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide I5A 2016-08-17 2017-04-26 Liu, W.J.,Lan, J.,Liu, K.,Deng, Y.,Yao, Y.,Wu, S.,Chen, H.,Bao, L.,Zhang, H.,Zhao, M.,Wang, Q.,Han, L.,Chai, Y.,Qi, J.,Zhao, J.,Meng, S.,Qin, C.,Gao, G.F.,Tan, W. Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol. 2017 198 873 882 5GSV 27903740 Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 142-5 2016-08-17 2017-04-26 Liu, W.J.,Lan, J.,Liu, K.,Deng, Y.,Yao, Y.,Wu, S.,Chen, H.,Bao, L.,Zhang, H.,Zhao, M.,Wang, Q.,Han, L.,Chai, Y.,Qi, J.,Zhao, J.,Meng, S.,Qin, C.,Gao, G.F.,Tan, W. Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol. 2017 198 873 882 5JJT Crystal structure of a type 5 serine/threonine protein phosphatase from Arabidopsis thaliana 2016-04-25 2017-04-26 Li, H.M.,Pu, H. Crystal structure of a type 5 serine/threonine protein phosphatase from Arabidopsis thaliana To Be Published 0 0 0 0 5JKF Crystal structure of esterase E22 2016-04-26 2017-04-26 Zhang, Y.,Yao, Q.,Wang, P. Structural basis for substrate recognition and catalysis of a novel esterase E22 with a homoserine transacetylase-like fold To Be Published 0 0 0 0 5JKJ Crystal structure of esterase E22 L374D mutant 2016-04-26 2017-04-26 Zhang, Y.,Yao, Q.,Wang, P. Structural basis for substrate recognition and catalysis of a novel esterase E22 with a homoserine transacetylase-like fold To Be Published 0 0 0 0 5WRO 28368282 Crystal structure of Drosophila enolase 2016-12-02 2017-04-26 Sun, C.,Xu, B.,Liu, X.,Zhang, Z.,Su, Z. Crystal structure of enolase from Drosophila melanogaster. Acta Crystallogr F Struct Biol 2017 73 228 234 5WWC 28377493 The crystal structure of Cren7 mutant L28M in complex with dsDNA 2016-12-31 2017-04-26 Zhang, Z.,Zhao, M.,Wang, L.,Chen, Y.,Dong, Y.,Gong, Y.,Huang, L. Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA Biochem. J. 2017 474 1727 1739 5G4C 27610633 Human SIRT2 catalyse short chain fatty acyl lysine 2016-05-09 2017-05-03 Jin, J.,He, B.,Zhang, X.,Lin, H.,Wang, Y. SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones. J. Am. Chem. Soc. 2016 138 12304 12307 5JLY Structure of Peroxiredoxin-1 from Schistosoma japonicum 2016-04-27 2017-05-03 Li, P.,Li, Y. Crystal structure of Peroxiredoxin-1 from Schistosoma japonicum To Be Published 0 0 0 0 5WRR 28432788 Crystal structure of Fam20A 2016-12-03 2017-05-03 Cui, J.,Zhu, Q.,Zhang, H.,Cianfrocco, M.A.,Leschziner, A.E.,Dixon, J.E.,Xiao, J. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding Elife 2017 6 0 0 5WRS 28432788 Crystal Structure of Fam20A in complex with ATP 2016-12-03 2017-05-03 Cui, J.,Zhu, Q.,Zhang, H.,Cianfrocco, M.A.,Leschziner, A.E.,Dixon, J.E.,Xiao, J. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding Elife 2017 6 0 0 5WUK 28111304 Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound 2016-12-19 2017-05-03 Li, L.,Feng, L.,Shi, M.,Zeng, J.,Chen, Z.,Zhong, L.,Huang, L.,Guo, W.,Huang, Y.,Qi, W.,Lu, C.,Li, E.,Zhao, K.,Gu, J. Split luciferase-based biosensors for characterizing EED binders Anal. Biochem. 2017 522 37 45 5X4R 28393837 Structure of the N-terminal domain (NTD) of MERS-CoV spike protein 2017-02-14 2017-05-03 Yuan, Y.,Cao, D.,Zhang, Y.,Ma, J.,Qi, J.,Wang, Q.,Lu, G.,Wu, Y.,Yan, J.,Shi, Y.,Zhang, X.,Gao, G.F. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Nat Commun 2017 8 15092 15092 5X4S 28393837 Structure of the N-terminal domain (NTD)of SARS-CoV spike protein 2017-02-14 2017-05-03 Yuan, Y.,Cao, D.,Zhang, Y.,Ma, J.,Qi, J.,Wang, Q.,Lu, G.,Wu, Y.,Yan, J.,Shi, Y.,Zhang, X.,Gao, G.F. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Nat Commun 2017 8 15092 15092 5GI0 28394309 Crystal structure of RNA editing factor MORF9/RIP9 2016-06-21 2017-05-10 Yan, J.,Zhang, Q.,Guan, Z.,Wang, Q.,Li, L.,Ruan, F.,Lin, R.,Zou, T.,Yin, P. MORF9 increases the RNA-binding activity of PLS-type pentatricopeptide repeat protein in plastid RNA editing Nat Plants 2017 3 17037 17037 5GJ9 28604689 Crystal structure of Arabidopsis thaliana ACO2 in complex with POA 2016-06-28 2017-05-10 Sun, X.,Li, Y.,He, W.,Ji, C.,Xia, P.,Wang, Y.,Du, S.,Li, H.,Raikhel, N.,Xiao, J.,Guo, H. Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nat Commun 2017 8 15758 15758 5GNJ 28514654 Structure of a transcription factor and DNA complex 2016-07-21 2017-05-10 Lian, T.F.,Xu, Y.P.,Li, L.F.,Su, X.D. Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep 2017 19 1334 1342 5JSG 28504676 Crystal structure of Spindlin1 bound to compound EML405 2016-05-08 2017-05-10 Bae, N.,Viviano, M.,Su, X.,Lv, J.,Cheng, D.,Sagum, C.,Castellano, S.,Bai, X.,Johnson, C.,Khalil, M.I.,Shen, J.,Chen, K.,Li, H.,Sbardella, G.,Bedford, M.T. Developing Spindlin1 small-molecule inhibitors by using protein microarrays Nat. Chem. Biol. 2017 13 750 756 5TO2 Crystal structure of streptavidin with one wild type subunit and three mutated subunits (N23A/S27D/S45A) 2016-10-16 2017-05-10 Zhang, M.,Biswas, S.,Deng, W.,Yu, H. Crystal structure of streptavidin with one wild type subunit and three mutated subunits (N23A/S27D/S45A) To Be Published 0 0 0 0 5GT9 28471355 The X-ray structure of 7beta-hydroxysteroid dehydrogenase 2016-08-19 2017-05-17 Wang, R.,Wu, J.,Jin, D.K.,Chen, Y.,Lv, Z.,Chen, Q.,Miao, Q.,Huo, X.,Wang, F. Structure of NADP(+)-bound 7 beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes Acta Crystallogr F Struct Biol 2017 73 246 252 5H3G 28471368 Crystal Structure of Oryza sativa Acyl-CoA-Binding Protein 1 2016-10-24 2017-05-17 Guo, Z.-H.,Chan, W.H.Y.,Kong, G.K.W.,Hao, Q.,Chye, M.-L. The first plant acyl-CoA-binding protein structures: the close homologues OsACBP1 and OsACBP2 from rice Acta Crystallogr D Struct Biol 2017 73 438 448 5H3I 28471368 Crystal Structure of Oryza sativa Acyl-CoA-Binding Protein 2 2016-10-24 2017-05-17 Guo, Z.-H.,Chan, W.H.Y.,Kong, G.K.W.,Hao, Q.,Chye, M.-L. The first plant acyl-CoA-binding protein structures: the close homologues OsACBP1 and OsACBP2 from rice Acta Crystallogr D Struct Biol 2017 73 438 448 5JVA 27297107 1.95 angstrom crystal structure of TAGRFP-T 2016-05-11 2017-05-17 Liu, R.,Liang, Q.N.,Du, S.Q.,Hu, X.J.,Ding, Y. The crystal structure of red fluorescent protein TagRFP-T reveals the mechanism of its superior photostability. Biochem. Biophys. Res. Commun. 2016 477 229 234 5XBF 28439001 Crystal Structure of Myo7b C-terminal MyTH4-FERM in complex with USH1C PDZ3 2017-03-17 2017-05-17 Li, J.,He, Y.,Weck, M.L.,Lu, Q.,Tyska, M.J.,Zhang, M. Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins. Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5GMJ 28617811 Crystal Structure of GRASP55 GRASP domain in complex with JAM-B C-terminus 2016-07-14 2017-05-24 Cartier-Michaud, A.,Bailly, A.L.,Betzi, S.,Shi, X.,Lissitzky, J.C.,Zarubica, A.,Serge, A.,Roche, P.,Lugari, A.,Hamon, V.,Bardin, F.,Derviaux, C.,Lembo, F.,Audebert, S.,Marchetto, S.,Durand, B.,Borg, J.P.,Shi, N.,Morelli, X.,Aurrand-Lions, M. Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis PLoS Genet. 2017 13 0 0 5K17 27685992 Crystal structure of CREN7-DSDNA (GTGATCGC) complex 2016-05-17 2017-05-24 Tian, L.,Zhang, Z.F.,Wang, H.,Zhao, M.,Dong, Y.,Gong, Y. Sequence-Dependent T:G Base Pair Opening in DNA Double Helix Bound by Cren7, a Chromatin Protein Conserved among Crenarchaea PLoS ONE 2016 11 0 0 5XHX Crystal structure of VqsR LBD domain from Pseudomonas aeruginosa 2017-04-24 2017-05-24 Gu, L.,He, Q.,Wang, K.,Wang, F. Crystal structure of VqsR LBD domain from Pseudomonas aeruginosa To Be Published 0 0 0 0 5GI4 29107486 DEAD-box RNA helicase 2016-06-22 2017-05-31 Xu, L.,Wang, L.,Peng, J.,Li, F.,Wu, L.,Zhang, B.,Lv, M.,Zhang, J.,Gong, Q.,Zhang, R.,Zuo, X.,Zhang, Z.,Wu, J.,Tang, Y.,Shi, Y. Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions. Structure 2017 25 1795 0 5GJU 29107486 DEAD-box RNA helicase 2016-07-02 2017-05-31 Xu, L.,Wang, L.,Peng, J.,Li, F.,Wu, L.,Zhang, B.,Lv, M.,Zhang, J.,Gong, Q.,Zhang, R.,Zuo, X.,Zhang, Z.,Wu, J.,Tang, Y.,Shi, Y. Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions. Structure 2017 25 1795 0 5GTM 28548099 Modified human MxA, nucleotide-free form 2016-08-22 2017-05-31 Chen, Y.,Zhang, L.,Graf, L.,Yu, B.,Liu, Y.,Kochs, G.,Zhao, Y.,Gao, S. Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET Nat Commun 2017 8 15744 15744 5JYK 29180814 Deg9 crystal under 289K 2016-05-14 2017-05-31 Ouyang, M.,Li, X.,Zhao, S.,Pu, H.,Shen, J.,Adam, Z.,Clausen, T.,Zhang, L. The crystal structure of Deg9 reveals a novel octameric-type HtrA protease Nat Plants 2017 3 973 982 5GJK 28438634 Crystal Structure of BAF47 and BAF155 Complex 2016-06-30 2017-06-07 Yan, L.,Xie, S.,Du, Y.,Qian, C. Structural Insights into BAF47 and BAF155 Complex Formation. J. Mol. Biol. 2017 429 1650 1660 5KWA 28419599 complete structure of the Mycobacterium tuberculosis proteasomal ATPase Mpa 2016-07-17 2017-06-07 Wu, Y.,Hu, K.,Li, D.,Bai, L.,Yang, S.,Jastrab, J.B.,Xiao, S.,Hu, Y.,Zhang, S.,Darwin, K.H.,Wang, T.,Li, H. Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease Mol. Microbiol. 2017 105 227 241 5WST 28262393 Crystal structure of Myo7a SAH 2016-12-08 2017-06-07 Li, J.,Chen, Y.,Deng, Y.,Unarta, I.C.,Lu, Q.,Huang, X.,Zhang, M. Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension Structure 2017 25 579 0 5WSU 28262393 Crystal structure of Myosin VIIa IQ5-SAH in complex with apo-CaM 2016-12-08 2017-06-07 Li, J.,Chen, Y.,Deng, Y.,Unarta, I.C.,Lu, Q.,Huang, X.,Zhang, M. Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension Structure 2017 25 579 0 5WSV 28262393 Crystal structure of Myosin VIIa IQ5 in complex with Ca2+-CaM 2016-12-08 2017-06-07 Li, J.,Chen, Y.,Deng, Y.,Unarta, I.C.,Lu, Q.,Huang, X.,Zhang, M. Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension Structure 2017 25 579 0 5X8F 28559280 Ternary complex structure of a double mutant I454RA456K of o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis bound with AMP and its product analogue OSB-NCoA at 1.76 angstrom 2017-03-02 2017-06-07 Chen, Y.,Li, T.L.,Lin, X.,Li, X.,Li, X.D.,Guo, Z. Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode J. Biol. Chem. 2017 292 12296 12310 5X8G 28559280 Binary complex structure of a double mutant I454RA456K of o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis bound with its product analogue OSB-NCoA at 1.90 angstrom 2017-03-02 2017-06-07 Chen, Y.,Li, T.L.,Lin, X.,Li, X.,Li, X.D.,Guo, Z. Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate-binding mode J. Biol. Chem. 2017 292 12296 12310 5GQT 28479247 Crystal structure of a specifier Protein from Arabidopsis thaliana 2016-08-08 2017-06-21 Zhang, W.,Zhou, Y.,Wang, K.,Dong, Y.,Wang, W.,Feng, Y. Crystal structure of the nitrile-specifier protein NSP1 from Arabidopsis thaliana Biochem. Biophys. Res. Commun. 2017 488 147 152 5WRW 28369529 Structure of human apo-SRP72 2016-12-04 2017-06-21 Gao, Y.,Zhang, Q.,Lang, Y.,Liu, Y.,Dong, X.,Chen, Z.,Tian, W.,Tang, J.,Wu, W.,Tong, Y.,Chen, Z. Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation J Mol Cell Biol 2017 9 220 230 5GIT 28186440 BTB domain of KEAP1 in complex with XX3 2016-06-25 2017-06-28 Wu, G.Z.,Zhu, L.L.,Yuan, X.,Chen, H.,Xiong, R.,Zhang, S.D.,Cheng, H.,Shen, Y.H.,An, H.Z.,Li, T.J.,Li, H.L.,Zhang, W.D. Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway. Antioxid. Redox Signal. 2017 27 754 768 5H5P 28623291 Crystal structure of Myelin-gene Regulatory Factor DNA binding domain 2016-11-09 2017-06-28 Zhen, X.,Li, B.,Hu, F.,Yan, S.,Meloni, G.,Li, H.,Shi, N. Crystal structure of the DNA-binding domain of Myelin-gene Regulatory Factor. Sci Rep 2017 7 3696 3696 5WWN 28244370 Crystal structure of Tsr1 2017-01-03 2017-06-28 Sun, Q.,Zhu, X.,Qi, J.,An, W.,Lan, P.,Tan, D.,Chen, R.,Wang, B.,Zheng, S.,Zhang, C.,Chen, X.,Zhang, W.,Chen, J.,Dong, M.Q.,Ye, K. Molecular architecture of the 90S small subunit pre-ribosome Elife 2017 6 0 0 5WWO 28244370 Crystal structure of Enp1 2017-01-03 2017-06-28 Sun, Q.,Zhu, X.,Qi, J.,An, W.,Lan, P.,Tan, D.,Chen, R.,Wang, B.,Zheng, S.,Zhang, C.,Chen, X.,Zhang, W.,Chen, J.,Dong, M.Q.,Ye, K. Molecular architecture of the 90S small subunit pre-ribosome Elife 2017 6 0 0 5WXM 28244370 Crystal structure of the Imp3 and Mpp10 complex 2017-01-07 2017-06-28 Sun, Q.,Zhu, X.,Qi, J.,An, W.,Lan, P.,Tan, D.,Chen, R.,Wang, B.,Zheng, S.,Zhang, C.,Chen, X.,Zhang, W.,Chen, J.,Dong, M.Q.,Ye, K. Molecular architecture of the 90S small subunit pre-ribosome Elife 2017 6 0 0 5WYL 28244370 Crystal structure of Chaetomium thermophilum Utp10 N-terminal domain in complex with Utp17 C-terminal helices 2017-01-13 2017-06-28 Sun, Q.,Zhu, X.,Qi, J.,An, W.,Lan, P.,Tan, D.,Chen, R.,Wang, B.,Zheng, S.,Zhang, C.,Chen, X.,Zhang, W.,Chen, J.,Dong, M.Q.,Ye, K. Molecular architecture of the 90S small subunit pre-ribosome Elife 2017 6 0 0 5XSQ 28659479 Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide 2017-06-15 2017-06-28 Zhu, T.,Song, H.,Peng, R.,Shi, Y.,Qi, J.,Gao, G.F. Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus J. Virol. 2017 91 0 0 5X57 28541346 Structure of GAR domain of ACF7 2017-02-15 2017-07-05 Ma, Y.,Yue, J.,Zhang, Y.,Shi, C.,Odenwald, M.,Liang, W.G.,Wei, Q.,Goel, A.,Gou, X.,Zhang, J.,Chen, S.Y.,Tang, W.J.,Turner, J.R.,Yang, F.,Liang, H.,Qin, H.,Wu, X. ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun 2017 8 15375 15375 5GKK Crystal structure of a homing endonuclease, I-TnaI 2016-07-04 2017-07-12 Ren, J. Crystal structure of a homing endonuclease, I-TnaI To Be Published 0 0 0 0 5GSB 27903740 Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 37-3 2016-08-15 2017-07-12 Liu, W.J.,Lan, J.,Liu, K.,Deng, Y.,Yao, Y.,Wu, S.,Chen, H.,Bao, L.,Zhang, H.,Zhao, M.,Wang, Q.,Han, L.,Chai, Y.,Qi, J.,Zhao, J.,Meng, S.,Qin, C.,Gao, G.F.,Tan, W. Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol. 2017 198 873 882 5JQL Crystal Structure of Phosphatidic acid Transporter Ups1/Mdm35 Void of Bound Phospholipid from Saccharomyces Cerevisiae at 2.9 Angstroms Resolution 2016-05-05 2017-07-12 Lu, J.,Chan, C.,Yu, L.,Fan, J.,Sun, F.,Zhai, Y. Molecular mechanism of mitochondrial phosphatidate transfer by Ups1 Commun Biol 2020 0 0 0 5JQM Crystal Structure of Phosphatidic acid Transporter Ups1/Mdm35 Void of Bound Phospholipid from Saccharomyces Cerevisiae at 1.5 Angstroms Resolution 2016-05-05 2017-07-12 Lu, J.,Chan, C.,Yu, L.,Fan, J.,Sun, F.,Zhai, Y. Molecular mechanism of mitochondrial phosphatidate transfer by Ups1 Commun Biol 2020 0 0 0 5XJN 28607077 cytochrome P450 CREJ in complex with (4-ethylphenyl) dihydrogen phosphate 2017-05-03 2017-07-12 Du, L.,Dong, S.,Zhang, X.,Jiang, C.,Chen, J.,Yao, L.,Wang, X.,Wan, X.,Liu, X.,Wang, X.,Huang, S.,Cui, Q.,Feng, Y.,Liu, S.J.,Li, S. Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5GIX 27441502 Human serum albumin-Palmitic acid-Fe(Hn3piT)Cl2 2016-06-25 2017-07-19 Qi, J.,Gou, Y.,Zhang, Y.,Yang, K.,Chen, S.,Liu, L.,Wu, X.,Wang, T.,Zhang, W.,Yang, F. Developing Anticancer Ferric Prodrugs Based on the N-Donor Residues of Human Serum Albumin Carrier IIA Subdomain J. Med. Chem. 2016 59 7497 7511 5GIY HSA-Palmitic acid-[RuCl5(ind)]2- 2016-06-25 2017-07-19 Yang, F.,Wang, T. Structure of HSA-Palmitic acid-[RuCl5(ind)]2- To Be Published 0 0 0 0 5GML Crystal Structure of GRASP Domain of GRASP55 with N terminal extra residues 2016-07-14 2017-07-19 Cartier-Michaud, A.,Betzi, S.,Shi, X.,Shi, N.,Morelli, X.,Aurrand-Lions, M. Structural relationship of the tandem PDZ tandem from Grasp55 and its implication in the unconventional secretion pathway to be published 0 0 0 0 5WTA 28258151 Crystal Structure of Staphylococcus aureus SdrE apo form 2016-12-10 2017-07-19 Zhang, Y.,Wu, M.,Hang, T.,Wang, C.,Yang, Y.,Pan, W.,Zang, J.,Zhang, M.,Zhang, X. Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion Biochem. J. 2017 474 1619 1631 5X62 28654751 Crystal structure of a carnosine N-methyltransferase bound by AdoHcy 2017-02-20 2017-07-26 Liu, X.,Wu, J.,Sun, Y.,Xie, W. Substrate Recognition Mechanism of the Putative Yeast Carnosine N-methyltransferase ACS Chem. Biol. 2017 12 2164 2171 5XHQ 28885614 Apolipoprotein N-acyl Transferase 2017-04-23 2017-07-26 Lu, G.,Xu, Y.,Zhang, K.,Xiong, Y.,Li, H.,Cui, L.,Wang, X.,Lou, J.,Zhai, Y.,Sun, F.,Zhang, X.C. Crystal structure of E. coli apolipoprotein N-acyl transferase Nat Commun 2017 8 15948 15948 5XPY 28739949 Structural basis of kindlin-mediated integrin recognition and activation 2017-06-05 2017-07-26 Li, H.,Deng, Y.,Sun, K.,Yang, H.,Liu, J.,Wang, M.,Zhang, Z.,Lin, J.,Wu, C.,Wei, Z.,Yu, C. Structural basis of kindlin-mediated integrin recognition and activation Proc. Natl. Acad. Sci. U.S.A. 2017 114 9349 9354 5XPZ 28739949 Structural basis of kindlin-mediated integrin recognition and activation 2017-06-05 2017-07-26 Li, H.,Deng, Y.,Sun, K.,Yang, H.,Liu, J.,Wang, M.,Zhang, Z.,Lin, J.,Wu, C.,Wei, Z.,Yu, C. Structural basis of kindlin-mediated integrin recognition and activation Proc. Natl. Acad. Sci. U.S.A. 2017 114 9349 9354 5XQ0 28739949 Structural basis of kindlin-mediated integrin recognition and activation 2017-06-05 2017-07-26 Li, H.,Deng, Y.,Sun, K.,Yang, H.,Liu, J.,Wang, M.,Zhang, Z.,Lin, J.,Wu, C.,Wei, Z.,Yu, C. Structural basis of kindlin-mediated integrin recognition and activation Proc. Natl. Acad. Sci. U.S.A. 2017 114 9349 9354 5GNV 28701415 Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain 2016-07-25 2017-08-02 Xia, Y.,Shang, Y.,Zhang, R.,Zhu, J. Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain Biochem. J. 2017 474 2817 2828 5GNV 28701415 Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain 2016-07-25 2017-08-02 Xia, Y.,Shang, Y.,Zhang, R.,Zhu, J. Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain Biochem. J. 2017 474 2817 2828 5H3R 28124121 Crystal Structure of mutant MarR C80S from E.coli complexed with operator DNA 2016-10-26 2017-08-02 Zhu, R.,Hao, Z.,Lou, H.,Song, Y.,Zhao, J.,Chen, Y.,Zhu, J.,Chen, P.R. Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator. J. Biol. Inorg. Chem. 2017 22 685 693 5XSD 28716923 XylFII-LytSN complex mutant - D103A 2017-06-13 2017-08-02 Li, J.,Wang, C.,Yang, G.,Sun, Z.,Guo, H.,Shao, K.,Gu, Y.,Jiang, W.,Zhang, P. Molecular mechanism of environmental d-xylose perception by a XylFII-LytS complex in bacteria Proc. Natl. Acad. Sci. U.S.A. 2017 114 8235 8240 5XSJ 28716923 XylFII-LytSN complex 2017-06-14 2017-08-02 Li, J.,Wang, C.,Yang, G.,Sun, Z.,Guo, H.,Shao, K.,Gu, Y.,Jiang, W.,Zhang, P. Molecular mechanism of environmental d-xylose perception by a XylFII-LytS complex in bacteria Proc. Natl. Acad. Sci. U.S.A. 2017 114 8235 8240 5XSS 28716923 XylFII molecule 2017-06-15 2017-08-02 Li, J.,Wang, C.,Yang, G.,Sun, Z.,Guo, H.,Shao, K.,Gu, Y.,Jiang, W.,Zhang, P. Molecular mechanism of environmental d-xylose perception by a XylFII-LytS complex in bacteria Proc. Natl. Acad. Sci. U.S.A. 2017 114 8235 8240 5GPO 28732057 The sensor domain structure of the zinc-responsive histidine kinase CzcS from Pseudomonas Aeruginosa 2016-08-03 2017-08-09 Wang, D.,Chen, W.,Huang, S.,He, Y.,Liu, X.,Hu, Q.,Wei, T.,Shang, H.,Gan, J.,Chen, H. Structural basis of Zn(II) induced metal detoxification and antibiotic resistance by histidine kinase CzcS in Pseudomonas aeruginosa PLoS Pathog. 2017 13 0 0 5GXO 28711502 Discovery of a compound that activates SIRT3 to deacetylate Manganese Superoxide Dismutase 2016-09-19 2017-08-09 Lu, J.,Zhang, H.,Chen, X.,Zou, Y.,Li, J.,Wang, L.,Wu, M.,Zang, J.,Yu, Y.,Zhuang, W.,Xia, Q.,Wang, J. A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase. Free Radic. Biol. Med. 2017 112 287 297 5X7Z 28743871 CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH P-AMINOSALICYLIC ACID 2017-02-28 2017-08-09 Gao, Y.R.,Li, D.F.,Fleming, J.,Zhou, Y.F.,Liu, Y.,Deng, J.Y.,Zhou, L.,Zhou, J.,Zhu, G.F.,Zhang, X.E.,Wang, D.C.,Bi, L.J. Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis Sci Rep 2017 7 6471 6471 5XQX 28802632 Human CDK8-CYCC in complex with compound 4: N-methyl-4-(4-pyridyl)-1H-pyrrole-2-carboxamide 2017-06-07 2017-08-09 Han, X.,Jiang, M.,Zhou, C.,Zhou, Z.,Xu, Z.,Wang, L.,Mayweg, A.V.,Niu, R.,Jin, T.G.,Yang, S. Discovery of potent and selective CDK8 inhibitors through FBDD approach Bioorg. Med. Chem. Lett. 2017 27 4488 4492 5XS2 28802632 CDK8-CYCC IN COMPLEX WITH COMPOUND 17:3-chloro-4-(4-pyridyl)-1H-pyrrole-2-carboxamide 2017-06-12 2017-08-09 Han, X.,Jiang, M.,Zhou, C.,Zhou, Z.,Xu, Z.,Wang, L.,Mayweg, A.V.,Niu, R.,Jin, T.G.,Yang, S. Discovery of potent and selective CDK8 inhibitors through FBDD approach Bioorg. Med. Chem. Lett. 2017 27 4488 4492 5GNC 30926664 Crystal structure of Phytophthora. sojae PSR2 2016-07-20 2017-08-16 He, J.Q.,Ye, W.W.,Choi, D.S.,Wu, B.X.,Zhai, Y.,Guo, B.D.,Duan, S.Y.,Wang, Y.C.,Gan, J.H.,Ma, W.B.,Ma, J.B. Structural analysis ofPhytophthorasuppressor of RNA silencing 2 (PSR2) reveals a conserved modular fold contributing to virulence. Proc. Natl. Acad. Sci. U.S.A. 2019 0 0 0 5H05 28303907 Crystal structure of AmyP E221Q in complex with MALTOTRIOSE 2016-10-03 2017-08-16 Liu, Y.,Yu, J.,Li, F.,Peng, H.,Zhang, X.,Xiao, Y.,He, C. Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13 Sci Rep 2017 7 44067 44067 5H06 28303907 Crystal structure of AmyP in complex with maltose 2016-10-03 2017-08-16 Liu, Y.,Yu, J.,Li, F.,Peng, H.,Zhang, X.,Xiao, Y.,He, C. Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13 Sci Rep 2017 7 44067 44067 5WXG 28808021 Structure of TAF PHD finger domain binds to H3(1-15)K4ac 2017-01-07 2017-08-16 Zhao, S.,Yang, M.,Zhou, W.,Zhang, B.,Cheng, Z.,Huang, J.,Zhang, M.,Wang, Z.,Wang, R.,Chen, Z.,Zhu, J.,Li, H. Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5WXH 28808021 Crystal structure of TAF3 PHD finger bound to H3K4me3 2017-01-07 2017-08-16 Zhao, S.,Yang, M.,Zhou, W.,Zhang, B.,Cheng, Z.,Huang, J.,Zhang, M.,Wang, Z.,Wang, R.,Chen, Z.,Zhu, J.,Li, H. Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5X07 28644006 Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site 2017-01-20 2017-08-16 Li, J.,Machado, A.C.D.,Guo, M.,Sagendorf, J.M.,Zhou, Z.,Jiang, L.,Chen, X.,Wu, D.,Qu, L.,Chen, Z.,Chen, L.,Rohs, R.,Chen, Y. Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site Biochemistry 2017 56 3745 3753 5X8I 28692292 Crystal structure of human CLK1 in complex with compound 25 2017-03-02 2017-08-16 Sun, Q.Z.,Lin, G.F.,Li, L.L.,Jin, X.T.,Huang, L.Y.,Zhang, G.,Yang, W.,Chen, K.,Xiang, R.,Chen, C.,Wei, Y.Q.,Lu, G.W.,Yang, S.Y. Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers J. Med. Chem. 2017 60 6337 6352 5XTA 28771688 Crystal structure of lpg1832, a VirK family protein from Legionella pneumophila 2017-06-18 2017-08-16 Zhang, N.,Yin, S.,Liu, S.,Sun, A.,Zhou, M.,Gong, X.,Ge, H. Crystal structure of lpg1832, a VirK family protein from Legionella pneumophila, reveals a novel fold for bacterial VirK proteins FEBS Lett. 2017 591 2929 2935 5GT7 30503338 Crystal Structure of Arg-bound CASTOR1 2016-08-18 2017-08-23 Zhou, Y.,Wang, C.,Xiao, Q.,Guo, L. Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states Biochem. Biophys. Res. Commun. 2019 508 387 391 5GT8 30503338 Crystal Structure of apo-CASTOR1 2016-08-18 2017-08-23 Zhou, Y.,Wang, C.,Xiao, Q.,Guo, L. Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states Biochem. Biophys. Res. Commun. 2019 508 387 391 5WX1 28835495 The closed-conformation crystal structure of the full-length pestivirus NS3 with its NS4A protease cofactor segment 2017-01-06 2017-08-23 Zheng, F.,Lu, G.,Li, L.,Gong, P.,Pan, Z. Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3. J. Virol. 2017 91 0 0 5XGP 28808056 structure of Sizzled from Xenopus laevis at 2.08 angstroms resolution 2017-04-15 2017-08-23 Bu, Q.,Li, Z.,Zhang, J.,Xu, F.,Liu, J.,Liu, H. The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted Frizzled-related proteins J. Biol. Chem. 2017 292 16055 16069 5GNE 28776986 Crystal structure of LapB from Legionella pneumophila 2016-07-20 2017-08-30 Zhang, N.,Yin, S.,Zhang, W.,Gong, X.,Zhang, N.,Fang, K.,Ge, H. Crystal Structure and Biochemical Characterization of an Aminopeptidase LapB from Legionella pneumophila. J. Agric. Food Chem. 2017 65 7569 7578 5GUV 29381856 The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D 2016-08-31 2017-08-30 Ye, F.,Kong, X.Q.,Zhang, H.,Liu, Y.,Shao, Z.,Jin, J.,Cai, Y.,Zhang, R.,Li, L.,Zhang, Y.W.,Liu, Y.C.,Zhang, C.,Xie, W.,Yu, K.,Ding, H.,Zhao, K.,Chen, S.,Jiang, H.,Baylin, S.B.,Luo, C. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol. 2018 13 772 781 5GOL Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain F598H mutant 2016-07-27 2017-09-06 Yuan, H.,Wei, Y.Z.,Tan, X.S. Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain F598H mutant To Be Published 0 0 0 0 5GTZ Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39 2016-08-24 2017-09-06 Yan, X.E.,Yun, C.H. Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39 To Be Published 0 0 0 0 5H48 28877468 Crystal structure of Cbln1 2016-10-31 2017-09-06 Zhong, C.,Shen, J.,Zhang, H.,Li, G.,Shen, S.,Wang, F.,Hu, K.,Cao, L.,He, Y.,Ding, J. Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep 2017 20 2328 2340 5H4C 28877468 Crystal structure of Cbln4 2016-10-31 2017-09-06 Zhong, C.,Shen, J.,Zhang, H.,Li, G.,Shen, S.,Wang, F.,Hu, K.,Cao, L.,He, Y.,Ding, J. Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep 2017 20 2328 2340 5XP7 28535041 C-Src in complex with ATP-CHCl 2017-06-01 2017-09-06 Ni, F.,Kung, A.,Duan, Y.,Shah, V.,Amador, C.D.,Guo, M.,Fan, X.,Chen, L.,Chen, Y.,McKenna, C.E.,Zhang, C. Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases. J. Am. Chem. Soc. 2017 139 7701 7704 5GVU crystal structure of BVDV NS3 helicase domain 2016-09-06 2017-09-13 Shi, J.,He, M.,Nie, Y.,Li, S.,Mao, X. crystal structure of BVDV NS3 helicase To Be Published 0 0 0 0 5GW0 28712807 Crystal structure of SNX16 PX-Coiled coil 2016-09-08 2017-09-13 Xu, J.,Zhang, L.,Ye, Y.,Shan, Y.,Wan, C.,Wang, J.,Pei, D.,Shu, X.,Liu, J. SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure 2017 25 1251 0 5GW1 28712807 Crystal structure of SNX16 PX-Coiled coil in space group P212121 2016-09-08 2017-09-13 Xu, J.,Zhang, L.,Ye, Y.,Shan, Y.,Wan, C.,Wang, J.,Pei, D.,Shu, X.,Liu, J. SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure 2017 25 1251 0 5H49 28877468 Crystal structure of Cbln1 2016-10-31 2017-09-13 Zhong, C.,Shen, J.,Zhang, H.,Li, G.,Shen, S.,Wang, F.,Hu, K.,Cao, L.,He, Y.,Ding, J. Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep 2017 20 2328 2340 5H4R 28838949 the complex of Glycoside Hydrolase 5 Lichenase from Caldicellulosiruptor sp. F32 E188Q mutant and cellotetraose 2016-11-02 2017-09-13 Meng, D.D.,Liu, X.,Dong, S.,Wang, Y.F.,Ma, X.Q.,Zhou, H.,Wang, X.,Yao, L.S.,Feng, Y.,Li, F.L. Structural insights into the substrate specificity of a glycoside hydrolase family 5 lichenase from Caldicellulosiruptor sp. F32 Biochem. J. 2017 474 3373 3389 5XS3 28655516 Crystal structure of HLA Class I antigen 2017-06-12 2017-09-13 Wei, P.,Yang, Y.,Liu, Z.,Luo, Z.,Tu, W.,Han, J.,Deng, Y.,Yin, L. Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis J. Invest. Dermatol. 2017 137 2238 2241 5XTN 28904203 Crystal structure of baculoviral sulfhydryl oxidase P33 (C155A, C158A mutant) 2017-06-20 2017-09-13 Kuang, W.,Zhang, H.,Wang, M.,Zhou, N.Y.,Deng, F.,Wang, H.,Gong, P.,Hu, Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function J. Virol. 2017 91 0 0 5XTO 28904203 Crystal structure of baculoviral sulfhydryl oxidase P33 (H114A mutant) 2017-06-20 2017-09-13 Kuang, W.,Zhang, H.,Wang, M.,Zhou, N.Y.,Deng, F.,Wang, H.,Gong, P.,Hu, Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function J. Virol. 2017 91 0 0 5XTP 28904203 Crystal structure of baculoviral sulfhydryl oxidase P33 (H227A mutant) 2017-06-20 2017-09-13 Kuang, W.,Zhang, H.,Wang, M.,Zhou, N.Y.,Deng, F.,Wang, H.,Gong, P.,Hu, Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function J. Virol. 2017 91 0 0 5XTQ 28904203 Crystal structure of baculoviral sulfhydryl oxidase P33 (H227D mutant) 2017-06-20 2017-09-13 Kuang, W.,Zhang, H.,Wang, M.,Zhou, N.Y.,Deng, F.,Wang, H.,Gong, P.,Hu, Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function J. Virol. 2017 91 0 0 5XTR 28904203 Crystal structure of baculoviral sulfhydryl oxidase P33 (R127A, E183A mutant) 2017-06-20 2017-09-13 Kuang, W.,Zhang, H.,Wang, M.,Zhou, N.Y.,Deng, F.,Wang, H.,Gong, P.,Hu, Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function J. Virol. 2017 91 0 0 5XWP 28757251 Crystal structure of LbuCas13a-crRNA-target RNA ternary complex 2017-06-30 2017-09-13 Liu, L.,Li, X.,Ma, J.,Li, Z.,You, L.,Wang, J.,Wang, M.,Zhang, X.,Wang, Y. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. Cell 2017 170 714 0 5Y0W 28827346 The structure of RVFV Gn head domain 2017-07-19 2017-09-13 Wu, Y.,Zhu, Y.H.,Gao, F.,Jiao, Y.J.,Oladejo, B.O.,Chai, Y.,Bi, Y.H.,Lu, S.,Dong, M.Q.,Zhang, C.,Huang, G.M.,Wong, G.,Li, N.,Zhang, Y.F.,Li, Y.,Feng, W.H.,Shi, Y.,Liang, M.F.,Zhang, R.G.,Qi, J.X.,Gao, G.F. Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5Y0Y 28827346 RVFV GN-AU 2017-07-19 2017-09-13 Wu, Y.,Zhu, Y.H.,Gao, F.,Jiao, Y.J.,Oladejo, B.O.,Chai, Y.,Bi, Y.H.,Lu, S.,Dong, M.Q.,Zhang, C.,Huang, G.M.,Wong, G.,Li, N.,Zhang, Y.F.,Li, Y.,Feng, W.H.,Shi, Y.,Liang, M.F.,Zhang, R.G.,Qi, J.X.,Gao, G.F. Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5Y10 28827346 SFTSV Gn head domain 2017-07-19 2017-09-13 Wu, Y.,Zhu, Y.H.,Gao, F.,Jiao, Y.J.,Oladejo, B.O.,Chai, Y.,Bi, Y.H.,Lu, S.,Dong, M.Q.,Zhang, C.,Huang, G.M.,Wong, G.,Li, N.,Zhang, Y.F.,Li, Y.,Feng, W.H.,Shi, Y.,Liang, M.F.,Zhang, R.G.,Qi, J.X.,Gao, G.F. Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5Y11 28827346 SFTSV GN with neutralizing antibody MAb4-5 2017-07-19 2017-09-13 Wu, Y.,Zhu, Y.H.,Gao, F.,Jiao, Y.J.,Oladejo, B.O.,Chai, Y.,Bi, Y.H.,Lu, S.,Dong, M.Q.,Zhang, C.,Huang, G.M.,Wong, G.,Li, N.,Zhang, Y.F.,Li, Y.,Feng, W.H.,Shi, Y.,Liang, M.F.,Zhang, R.G.,Qi, J.X.,Gao, G.F. Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5Y4D 28841137 Crystal Structure of AnkB Ankyrin Repeats in Complex with AnkR/AnkB Chimeric Autoinhibition Segment 2017-08-03 2017-09-13 Chen, K.,Li, J.,Wang, C.,Wei, Z.,Zhang, M. Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions. Elife 2017 6 0 0 5Y4E 28841137 Crystal Structure of AnkB Ankyrin Repeats R8-14 in complex with autoinhibition segment AI-b 2017-08-03 2017-09-13 Chen, K.,Li, J.,Wang, C.,Wei, Z.,Zhang, M. Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions. Elife 2017 6 0 0 5Y4F 28841137 Crystal Structure of AnkB Ankyrin Repeats R13-24 in complex with autoinhibition segment AI-c 2017-08-03 2017-09-13 Chen, K.,Li, J.,Wang, C.,Wei, Z.,Zhang, M. Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions. Elife 2017 6 0 0 5GXD Structure of acryloyl-CoA lyase PrpE from Dinoroseobacter shibae DFL 12 2016-09-17 2017-09-20 Zhang, Y.Z.,Wang, P.,Cao, H.Y. Structure of acryloyl-CoA lyase PrpE from Dinoroseobacter shibae DFL 12 To Be Published 0 0 0 0 5GXF Acryloyl-CoA reductase AcuI from Ruegeria pomeroyi DSS-3 2016-09-17 2017-09-20 Zhang, Y.Z.,Wang, P.,Cao, H.Y. Acryloyl-CoA reductase AcuI from Ruegeria pomeroyi DSS-3 To Be Published 0 0 0 0 5H6B 28857479 Crystal structure of a thermostable lipase from Marine Streptomyces 2016-11-11 2017-09-20 Zhao, Z.,Hou, S.,Lan, D.,Wang, X.,Liu, J.,Khan, F.I.,Wang, Y. Crystal structure of a lipase from Streptomyces sp. strain W007 - implications for thermostability and regiospecificity FEBS J. 2017 284 3506 3519 5H6G 28857479 Crystal structure of a thermostable lipase from Marine Streptomyces 2016-11-11 2017-09-20 Zhao, Z.,Hou, S.,Lan, D.,Wang, X.,Liu, J.,Khan, F.I.,Wang, Y. Crystal structure of a lipase from Streptomyces sp. strain W007 - implications for thermostability and regiospecificity FEBS J. 2017 284 3506 3519 5XKI 28904203 Crystal structure of baculoviral sulfhydryl oxidase AcP33 (wide type) 2017-05-07 2017-09-20 Kuang, W.,Zhang, H.,Wang, M.,Zhou, N.Y.,Deng, F.,Wang, H.,Gong, P.,Hu, Z. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function J. Virol. 2017 91 0 0 5XXY 29163822 Crystal structure of PD-L1 complexed with atezolizumab fab at 2.9A 2017-07-05 2017-09-20 Zhang, F.,Qi, X.,Wang, X.,Wei, D.,Wu, J.,Feng, L.,Cai, H.,Wang, Y.,Zeng, N.,Xu, T.,Zhou, A.,Zheng, Y. Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab. Oncotarget 2017 8 90215 90224 5Y61 28870806 YfiB-YfiR complexed with GMP 2017-08-10 2017-09-20 Zhou, L.,Xu, M.,Jiang, T. Structural insights into the functional role of GMP in modulating the YfiBNR system Biochem. Biophys. Res. Commun. 2017 493 637 642 5Y91 The structure of the MHC class I molecule of bony fishes provides insights into the conserved nature of the antigen-presenting system 2017-08-22 2017-09-20 Zhaosan, C.,Nianzhi, Z.,Chun, X. Crystal structure of bony fish MHC class I complex at 1.9 Angstroms resolution. To Be Published 0 0 0 0 5GW8 28433636 Crystal structure of a putative DAG-like lipase (MgMDL2) from Malassezia globosa 2016-09-09 2017-09-27 Lan, D.,Xu, H.,Xu, J.,Dubin, G.,Liu, J.,Iqbal Khan, F.,Wang, Y. Malassezia globosa MgMDL2 lipase: Crystal structure and rational modification of substrate specificity. Biochem. Biophys. Res. Commun. 2017 488 259 265 5GYY Plant receptor complex 2016-09-24 2017-09-27 Ma, R.,Han, Z.,Hu, Z.,Lin, G.,Gong, X.,Zhang, H.,June, N.,Chai, J. Plant receptor complex at 2.35 Angstroms resolution To Be Published 0 0 0 0 5H7E 28471359 Crystal Structure of native drCPDase 2016-11-18 2017-09-27 Han, W.,Cheng, J.,Zhou, C.,Hua, Y.,Zhao, Y. Crystal structure of the RNA 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans Acta Crystallogr F Struct Biol 2017 73 276 280 5JCB 28035796 Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1 2016-04-14 2017-09-27 Zhao, W.,Zhou, C.,Guan, Z.Y.,Yin, P.,Chen, F.,Tang, Y.J. Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4 beta-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin. ACS Chem. Biol. 2017 12 746 752 5WZH 29036323 Structure of APUM23-GGAAUUGACGG 2017-01-18 2017-09-27 Bao, H.,Wang, N.,Wang, C.,Jiang, Y.,Liu, J.,Xu, L.,Wu, J.,Shi, Y. Structural basis for the specific recognition of 18S rRNA by APUM23. Nucleic Acids Res. 2017 45 12005 12014 5WZI 29036323 Structure of APUM23-GGAGUUGACGG 2017-01-18 2017-09-27 Bao, H.,Wang, N.,Wang, C.,Jiang, Y.,Liu, J.,Xu, L.,Wu, J.,Shi, Y. Structural basis for the specific recognition of 18S rRNA by APUM23. Nucleic Acids Res. 2017 45 12005 12014 5Y6J 28904194 Structure of Tomato spotted wilt virus nucleocapsid protein with alternative oligomerization state 2017-08-12 2017-09-27 Guo, Y.,Liu, B.,Ding, Z.,Li, G.,Liu, M.,Zhu, D.,Sun, Y.,Dong, S.,Lou, Z. Distinct Mechanism for the Formation of the Ribonucleoprotein Complex of Tomato Spotted Wilt Virus. J. Virol. 2017 91 0 0 5GP0 29066356 Crystal structure of geraniol-NUDX1 complex 2016-07-30 2017-10-04 Liu, J.,Guan, Z.,Liu, H.,Qi, L.,Zhang, D.,Zou, T.,Yin, P. Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis. Mol Plant 2018 11 218 221 5GYL 36048082 Structure of Cicer arietinum 11S gloubulin 2016-09-22 2017-10-04 Sun, L.,Zhou, A.,Zhang, F. Crystallization and crystallographic studies of a novel chickpea 11S globulin. Acta Crystallogr.,Sect.F 2022 78 324 329 5H7Z 28979890 Apo structure of immunity protein TplEi of T6SS from Pseudomonas aeruginosa 2016-11-21 2017-10-04 Gao, X.P.,Mu, Z.X.,Qin, B.,Sun, Y.,Cui, S. Structure-Based Prototype Peptides Targeting the Pseudomonas aeruginosa Type VI Secretion System Effector as a Novel Antibacterial Strategy Front Cell Infect Microbiol 2017 7 411 411 5X0R 28963450 Crystal Structure of PXR LBD Complexed with SJB7 2017-01-23 2017-10-04 Lin, W.,Wang, Y.M.,Chai, S.C.,Lv, L.,Zheng, J.,Wu, J.,Zhang, Q.,Wang, Y.D.,Griffin, P.R.,Chen, T. SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun 2017 8 741 741 5X72 28929751 The crystal Structure PDE delta in complex with (rac)-p9 2017-02-23 2017-10-04 Jiang, Y.,Zhuang, C.,Chen, L.,Lu, J.,Dong, G.,Miao, Z.,Zhang, W.,Li, J.,Sheng, C. Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem. 2017 60 9400 9406 5X73 28929751 The crystal Structure PDE delta in complex with R-p9 2017-02-23 2017-10-04 Jiang, Y.,Zhuang, C.,Chen, L.,Lu, J.,Dong, G.,Miao, Z.,Zhang, W.,Li, J.,Sheng, C. Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem. 2017 60 9400 9406 5X74 28929751 The crystal Structure PDE delta in complex with compound (R, R)-1g 2017-02-23 2017-10-04 Jiang, Y.,Zhuang, C.,Chen, L.,Lu, J.,Dong, G.,Miao, Z.,Zhang, W.,Li, J.,Sheng, C. Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem. 2017 60 9400 9406 5XEA 29073031 Structure of Thogoto virus envelope glycoprotein 2017-04-03 2017-10-04 Peng, R.,Zhang, S.,Cui, Y.,Shi, Y.,Gao, G.F.,Qi, J. Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5XEB 29073031 Structure of the envelope glycoprotein of Dhori virus 2017-04-03 2017-10-04 Peng, R.,Zhang, S.,Cui, Y.,Shi, Y.,Gao, G.F.,Qi, J. Structures of human-infectingThogotovirusfusogens support a common ancestor with insect baculovirus Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5XOU 28911094 Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 7T8 on the guide strand 2017-05-31 2017-10-04 Sheng, G.,Gogakos, T.,Wang, J.,Zhao, H.,Serganov, A.,Juranek, S.,Tuschl, T.,Patel, D.J.,Wang, Y. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes Nucleic Acids Res. 2017 45 9149 9163 5XOW 28911094 Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 6'A7' on the target strand 2017-05-31 2017-10-04 Sheng, G.,Gogakos, T.,Wang, J.,Zhao, H.,Serganov, A.,Juranek, S.,Tuschl, T.,Patel, D.J.,Wang, Y. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes Nucleic Acids Res. 2017 45 9149 9163 5YDP 28821550 Crystal Structure of TetR Family Repressor AlkX from Dietzia sp. Strain DQ12-45-1b Implicated in Biodegradation of n-Alkanes 2017-09-14 2017-10-04 Liang, J.L.,Gao, Y.,He, Z.,Nie, Y.,Wang, M.,JiangYang, J.H.,Zhang, X.C.,Shu, W.S.,Wu, X.L. Crystal Structure of TetR Family Repressor AlkX from Dietzia sp. Strain DQ12-45-1b Implicated in Biodegradation ofn-Alkanes. Appl. Environ. Microbiol. 2017 83 0 0 5Y5W 30381828 Crystal structure of human Spindlin1 in complex with a histone H4K20(me3) peptide 2017-08-10 2017-10-11 Wang, C.,Zhan, L.,Wu, M.,Ma, R.,Yao, J.,Xiong, Y.,Pan, Y.,Guan, S.,Zhang, X.,Zang, J. Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail FEBS Lett. 2018 592 4098 4110 5YAX 28949917 Crystal structure of a human neutralizing antibody bound to a HBV preS1 peptide 2017-09-02 2017-10-11 Li, D.,He, W.,Liu, X.,Zheng, S.,Qi, Y.,Li, H.,Mao, F.,Liu, J.,Sun, Y.,Pan, L.,Du, K.,Ye, K.,Li, W.,Sui, J. A potent human neutralizing antibody Fc-dependently reduces established HBV infections Elife 2017 6 0 0 5X0W 28978479 Molecular mechanism for the binding between Sharpin and HOIP 2017-01-23 2017-10-18 Liu, J.,Wang, Y.,Gong, Y.,Fu, T.,Hu, S.,Zhou, Z.,Pan, L. Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly Cell Rep 2017 21 27 36 5X3H 28977725 The Y81G mutant of the UNG crystal structure from Nitratifractor salsuginis 2017-02-06 2017-10-18 Li, J.,Chen, R.,Yang, Y.,Zhang, Z.,Fang, G.C.,Xie, W.,Cao, W. An unconventional family 1 uracil DNA glycosylase in Nitratifractor salsuginis. FEBS J. 2017 284 4017 4034 5Y09 Crystal structure of Deg9 at 295 K 2017-07-15 2017-10-18 Ouyang, M.,Li, X.Y.,Zhao, S.,Zhang, L.X. Crystal structure of Deg9 at 295 K To Be Published 0 0 0 0 5GL8 The crystal structure of Nattokinase fragments 2016-07-10 2017-10-25 Ren, Y.,Pan, X.,Lyu, Q.,Liu, W. unpublished To Be Published 0 0 0 0 5GLE The structure of Vibrio anguillarum775 AngB-ICL 2016-07-10 2017-10-25 Du, J.S.,Deng, T.,Ma, Q.G. The structure of Vibrio anguillarum775 AngB-ICL protein To Be Published 0 0 0 0 5GT5 28028551 Structural basis of the specific activity and thermostability of pectate lyase (pelN) from Paenibacillus sp. 0602 2016-08-18 2017-10-25 Zhou, Z.,Liu, Y.,Chang, Z.,Wang, H.,Leier, A.,Marquez-Lago, T.T.,Ma, Y.,Li, J.,Song, J. Structure-based engineering of a pectate lyase with improved specific activity for ramie degumming. Appl. Microbiol. Biotechnol. 2017 101 2919 2929 5H3K Crystal structure of a hypothetical protein from Synechocystis 2016-10-25 2017-10-25 Dong, L.-L.,Wu, D.,Gao, X.-Q.,Zhou, M.,Liu, Z.-J.,Zhao, K.-H. Crystal structure of a hypothetical protein from Synechocystis To Be Published 0 0 0 0 5H43 28991411 Structural and mechanistical studies of the nuclear import by Importin-alpha 2016-10-28 2017-10-25 Zheng, W.,Wang, R.,Liu, X.,Tian, S.,Yao, B.,Chen, A.,Jin, S.,Li, Y. Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1 Traffic 2018 19 19 28 5TPS Structure of a Fc heterodimer 2016-10-21 2017-10-25 Wei, H.,Zhou, A. A new Fc heterodimer To be published 0 0 0 0 5Y1Z 28966017 Crystal structure of ZMYND8 PHD-BROMO-PWWP tandem in complex with Drebrin ADF-H domain 2017-07-22 2017-10-25 Yao, N.,Li, J.,Liu, H.,Wan, J.,Liu, W.,Zhang, M. The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin Structure 2017 25 1657 0 5Y1Z 28966017 Crystal structure of ZMYND8 PHD-BROMO-PWWP tandem in complex with Drebrin ADF-H domain 2017-07-22 2017-10-25 Yao, N.,Li, J.,Liu, H.,Wan, J.,Liu, W.,Zhang, M. The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin Structure 2017 25 1657 0 5Y9C 28951471 Crystal structure of HPV58 pentamer in complex with the Fab fragment of antibody A12A3 2017-08-24 2017-10-25 Li, Z.,Wang, D.,Gu, Y.,Song, S.,He, M.,Shi, J.,Liu, X.,Wei, S.,Li, J.,Yu, H.,Zheng, Q.,Yan, X.,Baker, T.S.,Zhang, J.,McLellan, J.S.,Li, S.,Xia, N. Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. MBio 2017 8 0 0 5Y9E 28951471 Crystal structure of HPV58 pentamer 2017-08-24 2017-10-25 Li, Z.,Wang, D.,Gu, Y.,Song, S.,He, M.,Shi, J.,Liu, X.,Wei, S.,Li, J.,Yu, H.,Zheng, Q.,Yan, X.,Baker, T.S.,Zhang, J.,McLellan, J.S.,Li, S.,Xia, N. Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. MBio 2017 8 0 0 5Y9F 28951471 Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 2017-08-24 2017-10-25 Li, Z.,Wang, D.,Gu, Y.,Song, S.,He, M.,Shi, J.,Liu, X.,Wei, S.,Li, J.,Yu, H.,Zheng, Q.,Yan, X.,Baker, T.S.,Zhang, J.,McLellan, J.S.,Li, S.,Xia, N. Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. MBio 2017 8 0 0 5J6P Crystal Structure of Mis18(17-118) from Schizosaccharomyces pombe 2016-04-05 2017-11-01 Shao, C.,Wang, C.,Zhang, M.,Zhang, X.,Zang, J. Crystal Structure of Mis18(17-118) from Schizosaccharomyces pombe To Be Published 0 0 0 0 5H52 29623422 Structure of Titanium-bound human serum transferrin 2016-11-04 2017-11-08 Curtin, J.P.,Wang, M.,Cheng, T.,Jin, L.,Sun, H. The role of citrate, lactate and transferrin in determining titanium release from surgical devices into human serum. J. Biol. Inorg. Chem. 2018 23 471 480 5HWL Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form 2016-01-29 2017-11-08 Zhang, X.,Wei, J.,Wu, S.,Zhang, H.P.,Luo, M.,Yang, X.L.,Liao, F.,Wang, D.Q. Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form To Be Published 0 0 0 0 5Y14 28659478 Crystal structure of LP-40/N44 2017-07-19 2017-11-08 Ding, X.,Zhang, X.,Chong, H.,Zhu, Y.,Wei, H.,Wu, X.,He, J.,Wang, X.,He, Y. Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition J. Virol. 2017 91 0 0 5YKS 29061304 Crystal structure of sucrose nonfermenting-related kinase (SNRK) 2017-10-16 2017-11-08 Wang, Y.L.,Wang, J.,Chen, X.,Wang, Z.X.,Wu, J.W. Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family. Biochem. Biophys. Res. Commun. 2018 495 1 6 5YLC 29079699 Crystal Structure of MCR-1 Catalytic Domain 2017-10-17 2017-11-08 Wei, P.,Song, G.,Shi, M.,Zhou, Y.,Liu, Y.,Lei, J.,Chen, P.,Yin, L. Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance. FASEB J. 2018 32 1085 1098 5YLE 29079699 MCR-1 complex with ethanolamine (ETA) 2017-10-17 2017-11-08 Wei, P.,Song, G.,Shi, M.,Zhou, Y.,Liu, Y.,Lei, J.,Chen, P.,Yin, L. Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance. FASEB J. 2018 32 1085 1098 5YLF 29079699 MCR-1 complex with D-glucose 2017-10-17 2017-11-08 Wei, P.,Song, G.,Shi, M.,Zhou, Y.,Liu, Y.,Lei, J.,Chen, P.,Yin, L. Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance. FASEB J. 2018 32 1085 1098 5H6Y The BPTF Bromodomain Recognising H4K12Cr peptide 2016-11-15 2017-11-15 Wang, Y.,Hao, Q. The BPTF Bromodomain Recognising H4K12Cr peptide To Be Published 0 0 0 0 5WWL 29180432 Crystal structure of the Schizogenesis pombe kinetochore Mis12C subcomplex 2017-01-02 2017-11-15 Zhou, X.,Zheng, F.,Wang, C.,Wu, M.,Zhang, X.,Wang, Q.,Yao, X.,Fu, C.,Zhang, X.,Zang, J. Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis. Proc. Natl. Acad. Sci. U.S.A. 2017 114 0 0 5Y1Y 29087414 Complex structure of nitroxoline with the first bromodomain of BRD4 2017-07-21 2017-11-15 Jiang, H.,Xing, J.,Wang, C.,Zhang, H.,Yue, L.,Wan, X.,Chen, W.,Ding, H.,Xie, Y.,Tao, H.,Chen, Z.,Jiang, H.,Chen, K.,Chen, S.,Zheng, M.,Zhang, Y.,Luo, C. Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues. Org. Biomol. Chem. 2017 15 9352 9361 5Y9G 29125121 Crystal structure of Salmonella SafD adhesin 2017-08-25 2017-11-15 Zeng, L.H.,Zhang, L.,Wang, P.R.,Meng, G. Structural basis of host recognition and biofilm formation by Salmonella Saf pili Elife 2017 6 0 0 5Y9H 29125121 Crystal structure of SafDAA-dsc complex 2017-08-25 2017-11-15 Zeng, L.H.,Zhang, L.,Wang, P.R.,Meng, G. Structural basis of host recognition and biofilm formation by Salmonella Saf pili Elife 2017 6 0 0 5YCO 28951215 Complex structure of PCNA with UHRF2 2017-09-07 2017-11-15 Chen, W.,Wu, M.,Hang, T.,Wang, C.,Zhang, X.,Zang, J. Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA. Biochem. Biophys. Res. Commun. 2017 494 575 580 5YL4 CRYSTAL STRUCTURE OF T2R-TTL-8WR COMPLEX 2017-10-17 2017-11-15 Fu, Z.Y.,Li, W.B. Design, synthesis and biological activity evaluation of plinabulin derivatives based on co-crystal structure To Be Published 0 0 0 0 5GVT Crystal structures of the serine protease domain of murine plasma kallikrein 2016-09-06 2017-11-22 Xu, M.,Xu, P.,Zhou, X.,Andreasen, P.,Jiang, L.,Huang, M. Crystal Structures of the Serine Protease Domain of Murine Plasma Kallikrein Chin.J.Struct.Chem. 2017 36 242 249 5H6X The crystal structure of RpoS fragment including a partial region 1.2 and region 2 from intracellular pathogen Legionella pneumophila 2016-11-15 2017-11-22 Zhang, N.,Chen, X.,Gong, X.,Li, T.,Xie, Z.,Hameed, M.F.,Wang, M.,Ge, H. High-Resolution Crystal Structure of RpoS Fragment including a Partial Region 1.2 and Region 2 from the Intracellular Pathogen Legionella pneumophila Crystals 2018 8 54 63 5H7F Crystal Structure of Mn-derivative drCPDase 2016-11-18 2017-11-22 Han, W.,Hua, Y.,Zhao, Y. Crystal Structure of Mn-derivative drCPDase To be published 0 0 0 0 5WY2 29263922 Human Snx5 PX domain in complex with Chlamydia IncE C terminus 2017-01-10 2017-11-22 Sun, Q.,Yong, X.,Sun, X.,Yang, F.,Dai, Z.,Gong, Y.,Zhou, L.,Zhang, X.,Niu, D.,Dai, L.,Liu, J.J.,Jia, D. Structural and functional insights into sorting nexin 5/6 interaction with bacterial effector IncE. Signal Transduct Target Ther 2017 2 17030 17030 5YM7 29039033 Crystal Structure of B562RIL without disulfide bond 2017-10-21 2017-11-22 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YOW 29070692 The post-fusion structure of the Heartland virus Gc glycoprotein 2017-10-31 2017-11-22 Zhu, Y.,Wu, Y.,Chai, Y.,Qi, J.,Peng, R.,Feng, W.H.,Gao, G.F. The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae. J. Virol. 2018 92 0 0 5WQ2 Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir 2016-11-22 2017-11-29 Li, B.,Qin, L. Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir To Be Published 0 0 0 0 5YEF 29076501 Crystal structure of CTCF ZFs2-8-Hs5-1aE 2017-09-17 2017-11-29 Yin, M.,Wang, J.,Wang, M.,Li, X.,Zhang, M.,Wu, Q.,Wang, Y. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites Cell Res. 2017 27 1365 1377 5YEL 29076501 Crystal structure of CTCF ZFs6-11-gb7CSE 2017-09-18 2017-11-29 Yin, M.,Wang, J.,Wang, M.,Li, X.,Zhang, M.,Wu, Q.,Wang, Y. Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites Cell Res. 2017 27 1365 1377 5WQ4 29394115 Crystal structure of OPTN and linear diubiquitin complex 2016-11-23 2017-12-06 Li, F.,Xu, D.,Wang, Y.,Zhou, Z.,Liu, J.,Hu, S.,Gong, Y.,Yuan, J.,Pan, L. Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation. Autophagy 2018 14 66 79 5XJ8 29167463 Crystal structure of PlsY (YgiH), an integral membrane glycerol 3-phosphate acyltransferase - the lysphosphatidic acid form 2017-04-30 2017-12-06 Li, Z.,Tang, Y.,Wu, Y.,Zhao, S.,Bao, J.,Luo, Y.,Li, D. Structural insights into the committed step of bacterial phospholipid biosynthesis. Nat Commun 2017 8 1691 1691 5XJ9 29167463 Crystal structure of PlsY (YgiH), an integral membrane glycerol 3-phosphate acyltransferase - the orthophosphate form 2017-04-30 2017-12-06 Li, Z.,Tang, Y.,Wu, Y.,Zhao, S.,Bao, J.,Luo, Y.,Li, D. Structural insights into the committed step of bacterial phospholipid biosynthesis. Nat Commun 2017 8 1691 1691 5Y38 29123114 Crystal structure of C7orf59-HBXIP complex 2017-07-28 2017-12-06 Zhang, T.,Wang, R.,Wang, Z.,Wang, X.,Wang, F.,Ding, J. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun 2017 8 1394 1394 5Y39 29123114 Crystal structure of Ragulator complex (p18 76-145) 2017-07-28 2017-12-06 Zhang, T.,Wang, R.,Wang, Z.,Wang, X.,Wang, F.,Ding, J. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun 2017 8 1394 1394 5Y5O 29187596 Crystal structure of the dUTPase of white spot syndrome virus in the apo state 2017-08-09 2017-12-06 Zang, K.,Li, F.,Ma, Q. The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner. J. Biol. Chem. 2018 293 1088 1099 5Y5P 29187596 Crystal structure of the dUTPase of white spot syndrome virus in complex with dU,PPi and Mg2+ 2017-08-09 2017-12-06 Zang, K.,Li, F.,Ma, Q. The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner. J. Biol. Chem. 2018 293 1088 1099 5Y5Q 29187596 Crystal structure of the WSSV dUTPase D88N/R158E mutant in complex with dUTP 2017-08-09 2017-12-06 Zang, K.,Li, F.,Ma, Q. The dUTPase of white spot syndrome virus assembles its active sites in a noncanonical manner. J. Biol. Chem. 2018 293 1088 1099 5YBJ 29183992 Structure of apo KANK1 ankyrin domain 2017-09-05 2017-12-06 Guo, Q.,Liao, S.,Zhu, Z.,Li, Y.,Li, F.,Xu, C. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J. Biol. Chem. 2018 293 557 566 5YBU 29183992 Structure of the KANK1 ankyrin domain in complex with KIF21A peptide 2017-09-05 2017-12-06 Guo, Q.,Liao, S.,Zhu, Z.,Li, Y.,Li, F.,Xu, C. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J. Biol. Chem. 2018 293 557 566 5YBV 29183992 The structure of the KANK2 ankyrin domain with the KIF21A peptide 2017-09-05 2017-12-06 Guo, Q.,Liao, S.,Zhu, Z.,Li, Y.,Li, F.,Xu, C. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J. Biol. Chem. 2018 293 557 566 5YHX 29229866 Structure of Lactococcus lactis ZitR, wild type 2017-10-01 2017-12-06 Zhu, R.,Song, Y.,Liu, H.,Yang, Y.,Wang, S.,Yi, C.,Chen, P.R. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc.Natl.Acad.Sci.USA 2017 114 13661 13666 5YHY 29229866 Structure of Lactococcus lactis ZitR, C30S mutant 2017-10-01 2017-12-06 Zhu, R.,Song, Y.,Liu, H.,Yang, Y.,Wang, S.,Yi, C.,Chen, P.R. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc.Natl.Acad.Sci.USA 2017 114 13661 13666 5YI0 29229866 Structure of Lactococcus lactis ZitR, C30AH42A mutant 2017-10-01 2017-12-06 Zhu, R.,Song, Y.,Liu, H.,Yang, Y.,Wang, S.,Yi, C.,Chen, P.R. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc.Natl.Acad.Sci.USA 2017 114 13661 13666 5YI1 29229866 Structure of Lactococcus lactis ZitR, C30AH42A mutant in apo form 2017-10-01 2017-12-06 Zhu, R.,Song, Y.,Liu, H.,Yang, Y.,Wang, S.,Yi, C.,Chen, P.R. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc.Natl.Acad.Sci.USA 2017 114 13661 13666 5YI3 29229866 Structure of Lactococcus lactis ZitR, C30S mutant in complex with DNA 2017-10-01 2017-12-06 Zhu, R.,Song, Y.,Liu, H.,Yang, Y.,Wang, S.,Yi, C.,Chen, P.R. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc.Natl.Acad.Sci.USA 2017 114 13661 13666 5O6B 29202194 Structure of ScPif1 in complex with GGGTTTT and ADP-AlF4 2017-06-06 2017-12-13 Lu, K.Y.,Chen, W.F.,Rety, S.,Liu, N.N.,Wu, W.Q.,Dai, Y.X.,Li, D.,Ma, H.Y.,Dou, S.X.,Xi, X.G. Insights into the structural and mechanistic basis of multifunctional S. cerevisiae Pif1p helicase. Nucleic Acids Res. 2018 46 1486 1500 5WSO crystal structure of BVDV NS3 helicase 2016-12-08 2017-12-13 Li, P.,Shi, J.,Wang, S.,Li, S.,Mao, X. Crystal structure of BVDV NS3 helicase To Be Published 0 0 0 0 5WT1 29214216 Pyrococcus abyssi methyltransferase PaTrm5a bound by SAH and cognate tRNA 2016-12-09 2017-12-13 Wang, C.,Jia, Q.,Zeng, J.,Chen, R.,Xie, W. Structural insight into the methyltransfer mechanism of the bifunctional Trm5. Sci Adv 2017 3 0 0 5WTL 28807152 Crystal structure of the periplasmic portion of outer membrane protein A (OmpA) from Capnocytophaga gingivalis 2016-12-13 2017-12-13 Dai, S.,Sun, C.,Tan, K.,Ye, S.,Zhang, R. Structure of thrombospondin type 3 repeats in bacterial outer membrane protein A reveals its intra-repeat disulfide bond-dependent calcium-binding capability. Cell Calcium 2017 66 78 89 5XBC Crystal Structure Basis for PEDV nsp1 2017-03-16 2017-12-13 Shen, Z.,Peng, G.Q. Crystal Structure Basis for PEDV nsp1 To Be Published 0 0 0 0 5XF7 29203529 Crystal structure of human protein disulfide isomerase-like protein of the testis 2017-04-08 2017-12-13 Li, H.,Yang, K.,Wang, W.,Niu, Y.,Li, J.,Dong, Y.,Liu, Y.,Wang, C.C.,Wang, L.,Liang, H. Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity J. Biol. Chem. 2018 293 1192 1202 5O6E 29202194 Structure of ScPif1 in complex with TTTGGGTT and ADP-AlF4 2017-06-06 2017-12-20 Lu, K.Y.,Chen, W.F.,Rety, S.,Liu, N.N.,Wu, W.Q.,Dai, Y.X.,Li, D.,Ma, H.Y.,Dou, S.X.,Xi, X.G. Insights into the structural and mechanistic basis of multifunctional S. cerevisiae Pif1p helicase. Nucleic Acids Res. 2018 46 1486 1500 5WSH 29950410 Structure of HLA-A2 P130 2016-12-07 2017-12-20 Zhang, Y.,Wu, Y.,Deng, M.,Xu, D.,Li, X.,Xu, Z.,Hu, J.,Zhang, H.,Liu, K.,Zhao, Y.,Gao, F.,Bi, S.,Gao, G.F.,Zhao, J.,Liu, W.J.,Meng, S. CD8+T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. J. Virol. 2018 92 0 0 5WTD 35690040 Structure of human serum transferrin bound ruthenium at N-lobe 2016-12-11 2017-12-20 Wang, M.,Wang, H.,Xu, X.,Lai, T.P.,Zhou, Y.,Hao, Q.,Li, H.,Sun, H. Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake. J.Inorg.Biochem. 2022 234 111885 111885 5WTT 28608634 Structure of the 093G9 Fab in complex with the epitope peptide 2016-12-14 2017-12-20 Zhong, C.,Huo, R.,Hu, K.,Shen, J.,Li, D.,Li, N.,Ding, J. Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9. J. Mol. Recognit. 2017 30 0 0 5Y9V 29191465 Crystal structure of diamondback moth ryanodine receptor N-terminal domain 2017-08-28 2017-12-20 Lin, L.,Liu, C.,Qin, J.,Wang, J.,Dong, S.,Chen, W.,He, W.,Gao, Q.,You, M.,Yuchi, Z. Crystal structure of ryanodine receptor N-terminal domain from Plutella xylostella reveals two potential species-specific insecticide-targeting sites. Insect Biochem. Mol. Biol. 2017 92 73 83 5YAY 29217769 Crystal structure of KANK1/KIF21A complex 2017-09-02 2017-12-20 Pan, W.,Sun, K.,Tang, K.,Xiao, Q.,Ma, C.,Yu, C.,Wei, Z. Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion. J. Biol. Chem. 2018 293 1944 1956 5YDG 29229384 Crystal structure of the Arabidopsis thaliana chloroplast RNA editing factors 2(MORF2) 2017-09-13 2017-12-20 Yang, J.,Zhang, M.,Wang, X. Crystal structure of the chloroplast RNA editing factor MORF2 Biochem. Biophys. Res. Commun. 2018 495 2038 2043 5WUP 29372897 Crystal structure of a insect group III chitinase (CAD1) from Ostrinia furnacalis 2016-12-20 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5WUS 29372897 Crystal structure of a insect group III chitinase (CAD2) from Ostrinia furnacalis 2016-12-20 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5WV8 29372897 Crystal structure of a mutant insect group III chitinase (CAD1-E217L) from Ostrinia furnacalis 2016-12-22 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5WV9 29372897 Crystal structure of a insect group III chitinase complex with (GlcNAc)6 (CAD1-(GlcNAc)6 ) from Ostrinia furnacalis 2016-12-23 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5WVB 29372897 Crystal structure of a mutant insect group III chitinase complex with (GlcNAc)6 (CAD1-E217L-(GlcNAc)6 ) from Ostrinia furnacalis 2016-12-23 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5WVF 29372897 Crystal structure of a mutant insect group III chitinase (CAD2-E647L) from Ostrinia furnacalis 2016-12-24 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5WVG 29372897 Crystal structure of a mutant insect group III chitinase complex with (GlcNAc)5 (CAD1-E647L-(GlcNAc)5 ) from Ostrinia furnacalis 2016-12-24 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5WVH 29372897 Crystal structure of an insect group III chitinase complex with (GlcNAc)6 (CAD2-(GlcNAc)6 ) from Ostrinia furnacalis 2016-12-24 2017-12-27 Liu, T.,Zhu, W.,Wang, J.,Zhou, Y.,Duan, Y.,Qu, M.,Yang, Q. The deduced role of a chitinase containing two nonsynergistic catalytic domains Acta Crystallogr D Struct Biol 2018 74 30 40 5X56 29098572 Crystal structure of PSB27 from Arabidopsis thaliana 2017-02-15 2017-12-27 Cheng, X.,Liu, J.,Huan, Z.,Fudong, L.,Shuya, Z.,Min, X.,Ke, R.,Yuhua, W.,Aigen, F. Crystal structure of Psb27 from Arabidopsis thaliana determined at a resolution of 1.85 angstrom. Photosyn. Res. 2018 136 139 146 5Y2V 29279392 Strcutrue of the full-length CcmR complexed with 2-OG from Synechocystis PCC6803 2017-07-27 2017-12-27 Jiang, Y.L.,Wang, X.P.,Sun, H.,Han, S.J.,Li, W.F.,Cui, N.,Lin, G.M.,Zhang, J.Y.,Cheng, W.,Cao, D.D.,Zhang, Z.Y.,Zhang, C.C.,Chen, Y.,Zhou, C.Z. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc. Natl. Acad. Sci. U.S.A. 2018 115 403 408 5Y2W 29279392 Structure of Synechocystis PCC6803 CcmR regulatory domain in complex with 2-PG 2017-07-27 2017-12-27 Jiang, Y.L.,Wang, X.P.,Sun, H.,Han, S.J.,Li, W.F.,Cui, N.,Lin, G.M.,Zhang, J.Y.,Cheng, W.,Cao, D.D.,Zhang, Z.Y.,Zhang, C.C.,Chen, Y.,Zhou, C.Z. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc. Natl. Acad. Sci. U.S.A. 2018 115 403 408 5Y3A 29123114 Crystal structure of Ragulator complex (p18 49-161) 2017-07-28 2017-12-27 Zhang, T.,Wang, R.,Wang, Z.,Wang, X.,Wang, F.,Ding, J. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1. Nat Commun 2017 8 1394 1394 5Y6Z 29164396 Crystal structure of the coxsackievirus A16 polymerase elongation complex 2017-08-15 2017-12-27 Bi, P.,Shu, B.,Gong, P. Crystal structure of the coxsackievirus A16 RNA-dependent RNA polymerase elongation complex reveals novel features in motif A dynamics Virol Sin 2017 32 548 552 5Y77 29208702 Crystal structure of Pseudomonas fluorescens Kynurenine 3-monooxygenase in complex with L-KYN (seMet derivative) 2017-08-16 2017-12-27 Gao, J.,Yao, L.,Xia, T.,Liao, X.,Zhu, D.,Xiang, Y. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048 FASEB J. 2018 32 2036 2045 5Y7A 29208702 Crystal structure of Pseudomonas fluorescens Kynurenine 3-monooxygenase in complex with L-KYN 2017-08-16 2017-12-27 Gao, J.,Yao, L.,Xia, T.,Liao, X.,Zhu, D.,Xiang, Y. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048 FASEB J. 2018 32 2036 2045 5Y9W 29109411 Crystal 1 for AtLURE1.2-AtPRK6LRR 2017-08-28 2017-12-27 Zhang, X.,Liu, W.,Nagae, T.T.,Takeuchi, H.,Zhang, H.,Han, Z.,Higashiyama, T.,Chai, J. Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun 2017 8 1331 1331 5Y9W 29109411 Crystal 1 for AtLURE1.2-AtPRK6LRR 2017-08-28 2017-12-27 Zhang, X.,Liu, W.,Nagae, T.T.,Takeuchi, H.,Zhang, H.,Han, Z.,Higashiyama, T.,Chai, J. Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun 2017 8 1331 1331 5YOB 29039033 Crystal Structure of flavodoxin without engineered disulfide bond 2017-10-27 2017-12-27 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YOC 29039033 Crystal Structure of flavodoxin with engineered disulfide bond C102-R125C 2017-10-27 2017-12-27 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YOE 29039033 Crystal Structure of flavodoxin with engineered disulfide bond A43C-L74C 2017-10-27 2017-12-27 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YS2 29261802 Structure of the domain IV(D_IV) of Pseudorabies virus glycoprotein B( PRV gB) 2017-11-12 2017-12-27 Li, X.,Yang, F.,Hu, X.,Tan, F.,Qi, J.,Peng, R.,Wang, M.,Chai, Y.,Hao, L.,Deng, J.,Bai, C.,Wang, J.,Song, H.,Tan, S.,Lu, G.,Gao, G.F.,Shi, Y.,Tian, K. Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design. PLoS Pathog. 2017 13 0 0 5YS6 Structure of the ectodomain of pseudorabies virus glycoproten B 2017-11-13 2017-12-27 Li, X.D.,Yang, F.L.,Hu, X.L. Two classes of protective antibodies against pseudorabies virus variant glycoprotein B: implications for vaccine design To Be Published 0 0 0 0 5YSL 29261802 Crystal structure of antibody 1H1 Fab 2017-11-14 2017-12-27 Li, X.,Yang, F.,Hu, X.,Tan, F.,Qi, J.,Peng, R.,Wang, M.,Chai, Y.,Hao, L.,Deng, J.,Bai, C.,Wang, J.,Song, H.,Tan, S.,Lu, G.,Gao, G.F.,Shi, Y.,Tian, K. Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design. PLoS Pathog. 2017 13 0 0 5YU9 27626175 Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib 2017-11-21 2017-12-27 Wang, A.,Yan, X.E.,Wu, H.,Wang, W.,Hu, C.,Chen, C.,Zhao, Z.,Zhao, P.,Li, X.,Wang, L.,Wang, B.,Ye, Z.,Wang, J.,Wang, C.,Zhang, W.,Gray, N.S.,Weisberg, E.L.,Chen, L.,Liu, J.,Yun, C.H.,Liu, Q. Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation. Oncotarget 2016 7 69760 69769 5WZX 29162643 Structural basis for a pentacyclic oleanane-type triterpenoid as a ligand of FXR 2017-01-19 2018-01-03 Lu, Y.,Zheng, W.,Lin, S.,Guo, F.,Zhu, Y.,Wei, Y.,Liu, X.,Jin, S.,Jin, L.,Li, Y. Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity Mol. Pharmacol. 2018 93 63 72 5YFC 29050944 Crystal structure of a new DPP III family member 2017-09-20 2018-01-03 Xu, T.,Xie, C.,Yao, D.,Zhou, C.Z.,Liu, J. Crystal structures of Aflatoxin-oxidase from Armillariella tabescens reveal a dual activity enzyme. Biochem. Biophys. Res. Commun. 2017 494 621 625 5YFD 29050944 Crystal structure of a new DPP III family member 2017-09-20 2018-01-03 Xu, T.,Xie, C.,Yao, D.,Zhou, C.Z.,Liu, J. Crystal structures of Aflatoxin-oxidase from Armillariella tabescens reveal a dual activity enzyme. Biochem. Biophys. Res. Commun. 2017 494 621 625 5Z02 Crystal structure of HIS6-tagged Mdm2 with nutlin-3a 2017-12-18 2018-01-03 Su, Z.D.,Cheng, X.Y. Crystal structure of HIS6-tagged Mdm2 with nutlin-3a to be published 0 0 0 0 5WWI Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1) 2017-01-01 2018-01-17 Zhao, M.,Liu, K.,Chai, Y.,Qi, J.,Liu, J.,Gao, G.F. Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1). To Be Published 0 0 0 0 5WWJ Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1) 2017-01-01 2018-01-17 Zhao, M.,Liu, K.,Chai, Y.,Qi, J.,Liu, J.,Gao, G.F. Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1). To Be Published 0 0 0 0 5WWU 30087171 Crystal Structure of HLA-A*2402 in complex with 2009 pandemic influenza A(H1N1) virus and avian influenza A(H5N1) virus-derived peptide H1-25 2017-01-05 2018-01-17 Zhao, M.,Liu, K.,Luo, J.,Tan, S.,Quan, C.,Zhang, S.,Chai, Y.,Qi, J.,Li, Y.,Bi, Y.,Xiao, H.,Wong, G.,Zhou, J.,Jiang, T.,Liu, W.,Yu, H.,Yan, J.,Liu, Y.,Shu, Y.,Wu, G.,Wu, A.,Gao, G.F.,Liu, W.J. Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio 2018 9 0 0 5WXC 30087171 Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 2) 2017-01-07 2018-01-17 Zhao, M.,Liu, K.,Luo, J.,Tan, S.,Quan, C.,Zhang, S.,Chai, Y.,Qi, J.,Li, Y.,Bi, Y.,Xiao, H.,Wong, G.,Zhou, J.,Jiang, T.,Liu, W.,Yu, H.,Yan, J.,Liu, Y.,Shu, Y.,Wu, G.,Wu, A.,Gao, G.F.,Liu, W.J. Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio 2018 9 0 0 5WXD 30087171 Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1) 2017-01-07 2018-01-17 Zhao, M.,Liu, K.,Luo, J.,Tan, S.,Quan, C.,Zhang, S.,Chai, Y.,Qi, J.,Li, Y.,Bi, Y.,Xiao, H.,Wong, G.,Zhou, J.,Jiang, T.,Liu, W.,Yu, H.,Yan, J.,Liu, Y.,Shu, Y.,Wu, G.,Wu, A.,Gao, G.F.,Liu, W.J. Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. Mbio 2018 9 0 0 5WXV The crystal structure of VabB-ICL domain from Vibrio anguillarum 775 2017-01-09 2018-01-17 Du, J.,Ma, Q. The crystal structures of isochorismatase domains from Vibrio anguillarum 775 To Be Published 0 0 0 0 5WXX 31101340 Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with citrate 2017-01-09 2018-01-17 Cao, D.D.,Zhang, C.P.,Zhou, K.,Jiang, Y.L.,Tan, X.F.,Xie, J.,Ren, Y.M.,Chen, Y.,Zhou, C.Z.,Hou, W.T. Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun. 2019 514 1108 1114 5WXZ 31101340 Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with D-aspartate 2017-01-09 2018-01-17 Cao, D.D.,Zhang, C.P.,Zhou, K.,Jiang, Y.L.,Tan, X.F.,Xie, J.,Ren, Y.M.,Chen, Y.,Zhou, C.Z.,Hou, W.T. Structural insights into the catalysis and substrate specificity of cyanobacterial aspartate racemase McyF. Biochem.Biophys.Res.Commun. 2019 514 1108 1114 5WY0 29703750 Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet 2017-01-10 2018-01-17 Peng, L.,Zhang, F.,Shang, R.,Wang, X.,Chen, J.,Chou, J.J.,Ma, J.,Wu, L.,Huang, Y. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain J. Biol. Chem. 2018 293 9981 9994 5WYI The Yaf9 YEATS domain Recognizing H3K122suc Peptide 2017-01-13 2018-01-17 Wang, Y.,Hao, Q. The Yaf9 YEATS domain Recognizing H3K122suc Peptide To Be Published 0 0 0 0 5XYX 28945083 The structure of p38 alpha in complex with a triazol inhibitor 2017-07-11 2018-01-17 Wang, Y.,Sun, Y.,Cao, R.,Liu, D.,Xie, Y.,Li, L.,Qi, X.,Huang, N. In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem. 2017 60 8552 8564 5XYY 28945083 The structure of p38 alpha in complex with a triazol inhibitor 2017-07-11 2018-01-17 Wang, Y.,Sun, Y.,Cao, R.,Liu, D.,Xie, Y.,Li, L.,Qi, X.,Huang, N. In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem. 2017 60 8552 8564 5Y4L 29291994 PRRSV nsp4 2017-08-04 2018-01-17 Shi, Y.,Lei, Y.,Ye, G.,Sun, L.,Fang, L.,Xiao, S.,Fu, Z.F.,Yin, P.,Song, Y.,Peng, G. Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus. Vet. Microbiol. 2018 213 114 122 5YMA 29361028 Crystal structure of ribosome assembly factor Efg1 2017-10-21 2018-01-17 Shu, S.,Ye, K. Structural and functional analysis of ribosome assembly factor Efg1. Nucleic Acids Res. 2018 46 2096 2106 5WY4 Crystal structure of Chaetomium thermophilum Utp10 N-terminal domain 2017-01-10 2018-01-24 Chen, R.,Zhu, X.,Ye, K. Crystal structure of Chaetomium thermophilum Utp10 N-terminal domain To Be Published 0 0 0 0 5WZM 28883454 Crystal structure of human secreted phospholipase A2 group IIE 2017-01-18 2018-01-24 Hou, S.,Xu, T.,Xu, J.,Qu, L.,Xu, Y.,Chen, L.,Liu, J. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep 2017 7 10815 10815 5X4G Crystal structure of Fab fragment of anti-CD147 monoclonal antibody 6H8 2017-02-13 2018-01-24 Zhang, M.-Y.,Lin, P.,Zhu, P.,Chen, Z.-N. Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody To Be Published 0 0 0 0 5Y20 29386129 Crystal structure of AL1 PHD finger bound to H3K4me3 2017-07-22 2018-01-24 Zhao, S.,Zhang, B.,Yang, M.,Zhu, J.,Li, H. Systematic Profiling of Histone Readers in Arabidopsis thaliana. Cell Rep 2018 22 1090 1102 5Y6K 29323384 Human serum trnasferrin bound to a fluorescent probe 2017-08-12 2018-01-24 Jiang, N.,Cheng, T.,Wang, M.,Chan, G.C.,Jin, L.,Li, H.,Sun, H. Tracking iron-associated proteomes in pathogens by a fluorescence approach. Metallomics 2018 10 77 82 5YC3 29386129 Crystal structure of AL3 PHD finger bound to H3K4me2 2017-09-06 2018-01-24 Zhao, S.,Zhang, B.,Yang, M.,Zhu, J.,Li, H. Systematic Profiling of Histone Readers in Arabidopsis thaliana. Cell Rep 2018 22 1090 1102 5YC4 29386129 Crystal structure of AL3 PHD finger bound to H3K4me3 2017-09-06 2018-01-24 Zhao, S.,Zhang, B.,Yang, M.,Zhu, J.,Li, H. Systematic Profiling of Histone Readers in Arabidopsis thaliana. Cell Rep 2018 22 1090 1102 5YXA 29285718 Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus 2017-12-04 2018-01-24 Wang, H.,Han, M.,Qi, J.,Hilgenfeld, R.,Luo, T.,Shi, Y.,Gao, G.F.,Song, H. Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus. Sci China Life Sci 2017 60 1403 1406 5WYD 29500457 Structural of Pseudomonas aeruginosa DspI 2017-01-12 2018-01-31 Liu, L.,Li, T.,Cheng, X.J.,Peng, C.T.,Li, C.C.,He, L.H.,Ju, S.M.,Wang, N.Y.,Ye, T.H.,Lian, M.,Xiao, Q.J.,Song, Y.J.,Zhu, Y.B.,Yu, L.T.,Wang, Z.L.,Bao, R. Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis. Sci Rep 2018 8 3928 3928 5X1S 29858276 PpkA-294 with Amppcp 2017-01-26 2018-01-31 Li, P.P.,Xu, D.Q.,Ma, T.Q.,Wang, D.Y.,Li, W.D.,He, J.H.,Ran, T.T.,Wang, W.W. Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J. 2018 475 2209 2224 5X1T 29858276 PpkA-294 2017-01-26 2018-01-31 Li, P.P.,Xu, D.Q.,Ma, T.Q.,Wang, D.Y.,Li, W.D.,He, J.H.,Ran, T.T.,Wang, W.W. Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J. 2018 475 2209 2224 5X88 28932264 A crystal structure of cutinases from Malbranchea cinnamomea 2017-03-01 2018-01-31 Duan, X.,Liu, Y.,You, X.,Jiang, Z.,Yang, S.,Yang, S. High-level expression and characterization of a novel cutinase from Malbranchea cinnamomea suitable for butyl butyrate production. Biotechnol Biofuels 2017 10 223 223 5XSI 29203646 The catalytic domain of GdpP 2017-06-14 2018-01-31 Wang, F.,He, Q.,Su, K.,Wei, T.,Xu, S.,Gu, L. Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase Biochem. J. 2018 475 191 205 5XSN 29203646 The catalytic domain of GdpP with c-di-AMP 2017-06-14 2018-01-31 Wang, F.,He, Q.,Su, K.,Wei, T.,Xu, S.,Gu, L. Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase Biochem. J. 2018 475 191 205 5XSP 29203646 The catalytic domain of GdpP with 5'-pApA 2017-06-15 2018-01-31 Wang, F.,He, Q.,Su, K.,Wei, T.,Xu, S.,Gu, L. Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase Biochem. J. 2018 475 191 205 5XT3 29203646 The catalytic domain of GdpP with c-di-GMP 2017-06-16 2018-01-31 Wang, F.,He, Q.,Su, K.,Wei, T.,Xu, S.,Gu, L. Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase Biochem. J. 2018 475 191 205 5YEW 29483649 Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion 2017-09-20 2018-01-31 Yan, L.,Qi, Y.,Huang, X.,Yu, C.,Lan, L.,Guo, X.,Rao, Z.,Hu, J.,Lou, Z. Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion Nat. Struct. Mol. Biol. 2018 25 233 243 5YJ6 29344087 The exoglucanase CelS from Clostridium thermocellum 2017-10-09 2018-01-31 Liu, Y.J.,Liu, S.,Dong, S.,Li, R.,Feng, Y.,Cui, Q. Determination of the native features of the exoglucanase Cel48S from Clostridium thermocellum Biotechnol Biofuels 2018 11 6 6 5Z3R 31226491 Crystal Structure of Delta 5-3-Ketosteroid Isomerase from Mycobacterium sp. 2018-01-08 2018-01-31 Peng, F.,Cheng, X.Y.,Wang, H.,Song, S.,Chen, T.,Li, X.,He, Y.,Huang, Y.Q.,Liu, S.,Yang, F.,Su, Z.D. Structure-based reconstruction of a Mycobacterium hypothetical protein into an active Delta5-3-ketosteroid isomerase. Biochim Biophys Acta Proteins 2019 1867 821 830 5XVA 29190083 Crystal Structure of PAK4 in complex with inhibitor CZH216 2017-06-27 2018-02-07 Hao, C.,Zhao, F.,Song, H.,Guo, J.,Li, X.,Jiang, X.,Huan, R.,Song, S.,Zhang, Q.,Wang, R.,Wang, K.,Pang, Y.,Liu, T.,Lu, T.,Huang, W.,Wang, J.,Lin, B.,He, Z.,Li, H.,Li, F.,Zhao, D.,Cheng, M. Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem. 2018 61 265 285 5XVF 29190083 Crystal Structure of PAK4 in complex with inhibitor CZH062 2017-06-27 2018-02-07 Hao, C.,Zhao, F.,Song, H.,Guo, J.,Li, X.,Jiang, X.,Huan, R.,Song, S.,Zhang, Q.,Wang, R.,Wang, K.,Pang, Y.,Liu, T.,Lu, T.,Huang, W.,Wang, J.,Lin, B.,He, Z.,Li, H.,Li, F.,Zhao, D.,Cheng, M. Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem. 2018 61 265 285 5XVG 29190083 Crystal Structure of PAK4 in complex with inhibitor CZH226 2017-06-27 2018-02-07 Hao, C.,Zhao, F.,Song, H.,Guo, J.,Li, X.,Jiang, X.,Huan, R.,Song, S.,Zhang, Q.,Wang, R.,Wang, K.,Pang, Y.,Liu, T.,Lu, T.,Huang, W.,Wang, J.,Lin, B.,He, Z.,Li, H.,Li, F.,Zhao, D.,Cheng, M. Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem. 2018 61 265 285 5YK0 29350349 The complex structure of Rv3197-ADP from Mycobacterium tuberculosis 2017-10-11 2018-02-07 Zhang, Q.,Liu, H.,Liu, X.,Jiang, D.,Zhang, B.,Tian, H.,Yang, C.,Guddat, L.W.,Yang, H.,Mi, K.,Rao, Z. Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell 2018 9 971 975 5YK1 29350349 The complex structure of Rv3197-AMPPNP from Mycobacterium tuberculosis 2017-10-11 2018-02-07 Zhang, Q.,Liu, H.,Liu, X.,Jiang, D.,Zhang, B.,Tian, H.,Yang, C.,Guddat, L.W.,Yang, H.,Mi, K.,Rao, Z. Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell 2018 9 971 975 5YP6 29456799 RORgamma (263-509) complexed with SRC2 and Compound 6 2017-11-01 2018-02-07 Wang, Y.,Cai, W.,Tang, T.,Liu, Q.,Yang, T.,Yang, L.,Ma, Y.,Zhang, G.,Huang, Y.,Song, X.,Orband-Miller, L.A.,Wu, Q.,Zhou, L.,Xiang, Z.,Xiang, J.N.,Leung, S.,Shao, L.,Lin, X.,Lobera, M.,Ren, F. From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists ACS Med Chem Lett 2018 9 120 124 5YQG 29382713 The structure of 14-3-3 and pNumb peptide 2017-11-06 2018-02-07 Chen, X.,Liu, Z.,Shan, Z.,Yao, W.,Gu, A.,Wen, W. Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex. J. Biol. Chem. 2018 293 4149 4158 5WSK Structure of Ribulose-1,5-bisphosphate carboxylase/oxygenase from wheat 2016-12-07 2018-02-14 Ma, Y.,Liu, C. Structure of Ribulose-1,5-bisphosphate carboxylase/oxygenase from wheat To Be Published 0 0 0 0 5X4H 30053256 The crystal structure of Pyrococcus furiosus RecJ (wild-type) 2017-02-13 2018-02-14 Li, M.J.,Yi, G.S.,Yu, F.,Zhou, H.,Chen, J.N.,Xu, C.Y.,Wang, F.P.,Xiao, X.,He, J.H.,Liu, X.P. The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45. Nucleic Acids Res. 2017 45 12551 12564 5X4I 30053256 Pyrococcus furiosus RecJ (D83A, Mn-soaking) 2017-02-13 2018-02-14 Li, M.J.,Yi, G.S.,Yu, F.,Zhou, H.,Chen, J.N.,Xu, C.Y.,Wang, F.P.,Xiao, X.,He, J.H.,Liu, X.P. The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45. Nucleic Acids Res. 2017 45 12551 12564 5X4J 30053256 The crystal structure of Pyrococcus furiosus RecJ (Zn-soaking) 2017-02-13 2018-02-14 Li, M.J.,Yi, G.S.,Yu, F.,Zhou, H.,Chen, J.N.,Xu, C.Y.,Wang, F.P.,Xiao, X.,He, J.H.,Liu, X.P. The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45. Nucleic Acids Res. 2017 45 12551 12564 5X4K 30053256 The complex crystal structure of Pyrococcus furiosus RecJ and CMP 2017-02-13 2018-02-14 Li, M.J.,Yi, G.S.,Yu, F.,Zhou, H.,Chen, J.N.,Xu, C.Y.,Wang, F.P.,Xiao, X.,He, J.H.,Liu, X.P. The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45. Nucleic Acids Res. 2017 45 12551 12564 5YC0 29425101 Crystal structure of LP-46/N44 2017-09-05 2018-02-14 Zhu, Y.,Zhang, X.,Ding, X.,Chong, H.,Cui, S.,He, J.,Wang, X.,He, Y. Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus J. Biol. Chem. 2018 293 5323 5334 5WTU Crystal structure of DndE G21/24K mutant involved in DNA phosphorothioation 2016-12-14 2018-02-21 Yao, P.,Liu, Y.,Wang, C.,Cao, C. Crystal structure of DndE G21/24K mutant involved in DNA phosphorothioation To Be Published 0 0 0 0 5X5P 35690040 Human serum transferrin bound to ruthenium NTA 2017-02-17 2018-02-21 Wang, M.,Wang, H.,Xu, X.,Lai, T.P.,Zhou, Y.,Hao, Q.,Li, H.,Sun, H. Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake. J.Inorg.Biochem. 2022 234 111885 111885 5X6A Crystal structure of an endoglucanase PMO-5 2017-02-21 2018-02-21 Shen, Q. Crystal structure of an endoglucanase PMO-5 To Be Published 0 0 0 0 5YDR 29471350 Structure of DNMT1 RFTS domain in complex with ubiquitin 2017-09-14 2018-02-21 Li, T.,Wang, L.,Du, Y.,Xie, S.,Yang, X.,Lian, F.,Zhou, Z.,Qian, C. Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation. Nucleic Acids Res. 2018 46 3218 3231 5YWZ 29408528 AID-SUN tandem of SUN1 2017-11-30 2018-02-21 Xu, Y.,Li, W.,Ke, H.,Feng, W. Structural conservation of the autoinhibitory domain in SUN proteins Biochem. Biophys. Res. Commun. 2018 496 1337 1343 6AY3 29155580 CREBBP bromodomain in complex with Cpd16 (5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1H-indole-3-carboxamide) 2017-09-07 2018-02-21 Bronner, S.M.,Murray, J.,Romero, F.A.,Lai, K.W.,Tsui, V.,Cyr, P.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Choo, E.F.,Clark, K.R.,Crawford, T.D.,Jayaram, H.,Kaufman, S.,Li, R.,Li, Y.,Liao, J.,Liang, X.,Liu, W.,Ly, J.,Maher, J.,Wai, J.,Wang, F.,Zheng, A.,Zhu, X.,Magnuson, S. A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. J. Med. Chem. 2017 60 10151 10171 6AY5 29155580 CREBBP bromodomain in complex with Cpd17 (5-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-3-methylbenzo[d]thiazol-2(3H)-one) 2017-09-07 2018-02-21 Bronner, S.M.,Murray, J.,Romero, F.A.,Lai, K.W.,Tsui, V.,Cyr, P.,Beresini, M.H.,de Leon Boenig, G.,Chen, Z.,Choo, E.F.,Clark, K.R.,Crawford, T.D.,Jayaram, H.,Kaufman, S.,Li, R.,Li, Y.,Liao, J.,Liang, X.,Liu, W.,Ly, J.,Maher, J.,Wai, J.,Wang, F.,Zheng, A.,Zhu, X.,Magnuson, S. A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. J. Med. Chem. 2017 60 10151 10171 5YB2 29535974 Crystal structure of LP-11/N44 2017-09-03 2018-02-28 Zhang, X.,Zhu, Y.,Hu, H.,Zhang, S.,Wang, P.,Chong, H.,He, J.,Wang, X.,He, Y. Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket Front Cell Infect Microbiol 2018 8 51 51 5YB3 29535974 Crystal structure of HP23L/N36 2017-09-03 2018-02-28 Zhang, X.,Zhu, Y.,Hu, H.,Zhang, S.,Wang, P.,Chong, H.,He, J.,Wang, X.,He, Y. Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket Front Cell Infect Microbiol 2018 8 51 51 5YB4 29535974 Crystal structure of HP23LN36KR 2017-09-03 2018-02-28 Zhang, X.,Zhu, Y.,Hu, H.,Zhang, S.,Wang, P.,Chong, H.,He, J.,Wang, X.,He, Y. Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket Front Cell Infect Microbiol 2018 8 51 51 5YGH 29454707 Crystal Structure of the Capsid Protein from Zika Virus 2017-09-23 2018-02-28 Shang, Z.,Song, H.,Shi, Y.,Qi, J.,Gao, G.F. Crystal Structure of the Capsid Protein from Zika Virus. J. Mol. Biol. 2018 430 948 962 5XP6 29382822 native structure of NDM-1 crystallized at pH5.5 2017-06-01 2018-03-07 Wang, R.,Lai, T.P.,Gao, P.,Zhang, H.,Ho, P.L.,Woo, P.C.,Ma, G.,Kao, R.Y.,Li, H.,Sun, H. Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors Nat Commun 2018 9 439 439 5XP9 29382822 Crystal structure of Bismuth bound NDM-1 2017-06-01 2018-03-07 Wang, R.,Lai, T.P.,Gao, P.,Zhang, H.,Ho, P.L.,Woo, P.C.,Ma, G.,Kao, R.Y.,Li, H.,Sun, H. Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors Nat Commun 2018 9 439 439 5N8R 29429875 Crystal Structure of Drosophilia DHX36 helicase in complex with GAGCACTGC 2017-02-24 2018-03-14 Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G. Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model. Structure 2018 26 403 0 5N8Z Crystal Structure of Drosophila DHX36 helicase in complex with CTCTCCCTT 2017-02-24 2018-03-14 Chen, W.-F.,Rety, S.,Guo, H.-L.,Wu, W.-Q.,Liu, N.-N.,Liu, Q.-W.,Dai, Y.-X.,Xi, X.-G. Structural and mechanistic insights into DHX36-mediated innate immunity and G-quadruplex unfolding To Be Published 0 0 0 0 5N96 29429875 Crystal Structure of Drosophila DHX36 helicase in complex with AGGGTTTTTT 2017-02-24 2018-03-14 Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G. Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model. Structure 2018 26 403 0 5N98 29429875 Crystal Structure of Drosophila DHX36 helicase in complex with TAGGGTTTT 2017-02-24 2018-03-14 Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G. Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model. Structure 2018 26 403 0 5N9A 29429875 Crystal Structure of Drosophila DHX36 helicase in complex with GTTAGGGTT 2017-02-24 2018-03-14 Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G. Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model. Structure 2018 26 403 0 5N9D 29429875 Crystal Structure of Drosophila DHX36 helicase in complex with GGGTTAGGGT 2017-02-24 2018-03-14 Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G. Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model. Structure 2018 26 403 0 5XUR 29465985 Crystal Structure of Rv2466c C22S Mutant 2017-06-25 2018-03-14 Negri, A.,Javidnia, P.,Mu, R.,Zhang, X.,Vendome, J.,Gold, B.,Roberts, J.,Barman, D.,Ioerger, T.,Sacchettini, J.C.,Jiang, X.,Burns-Huang, K.,Warrier, T.,Ling, Y.,Warren, J.D.,Oren, D.A.,Beuming, T.,Wang, H.,Wu, J.,Li, H.,Rhee, K.Y.,Nathan, C.F.,Liu, G.,Somersan-Karakaya, S. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. ACS Infect Dis 2018 4 771 787 5YKH 29490074 Crystal structure of the engineered nine-repeat PUF domain 2017-10-14 2018-03-14 Zhao, Y.Y.,Mao, M.W.,Zhang, W.J.,Wang, J.,Li, H.T.,Yang, Y.,Wang, Z.,Wu, J.W. Expanding RNA binding specificity and affinity of engineered PUF domains. Nucleic Acids Res. 2018 46 4771 4782 5YKI 29490074 Crystal structure of the engineered nine-repeat PUF domain in complex with cognate 9nt-RNA 2017-10-14 2018-03-14 Zhao, Y.Y.,Mao, M.W.,Zhang, W.J.,Wang, J.,Li, H.T.,Yang, Y.,Wang, Z.,Wu, J.W. Expanding RNA binding specificity and affinity of engineered PUF domains. Nucleic Acids Res. 2018 46 4771 4782 5YO4 29039033 Crystal Structure of B562RIL with engineered disulfide bond K27C-A79C 2017-10-26 2018-03-14 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YO5 29039033 Crystal Structure of B562RIL with engineered disulfide bond A20C-Q25C 2017-10-26 2018-03-14 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YO6 29039033 Crystal Structure of B562RIL with engineered disulfide bond T9C-A36C 2017-10-26 2018-03-14 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YOG 29039033 Crystal Structure of flavodoxin with engineered disulfide bond N14C-C93 2017-10-27 2018-03-14 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5YPO 29281827 Crystal structure of PSD-95 GK domain in complex with phospho-SAPAP peptide 2017-11-02 2018-03-14 Zhu, J.,Zhou, Q.,Shang, Y.,Li, H.,Peng, M.,Ke, X.,Weng, Z.,Zhang, R.,Huang, X.,Li, S.S.C.,Feng, G.,Lu, Y.,Zhang, M. Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. Cell Rep 2017 21 3781 3793 5YY8 29497022 Crystal structure of the Kelch domain of human NS1-BP 2017-12-08 2018-03-14 Guo, L.,Liu, Y. Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 angstrom resolution. Acta Crystallogr F Struct Biol 2018 74 174 178 5N9E Crystal Structure of Drosophila DHX36 helicase in complex with TGGGGATTT 2017-02-24 2018-03-21 Chen, W.-F.,Rety, S.,Hai-Lei Guo, H.-L.,Wu, W.-Q.,Liu, N.-N.,Liu, Q.-W.,Dai, Y.-X.,Xi, X.-G. Structural and mechanistic insights into DHX36-mediated innate immunity and G-quadruplex unfolding To Be Published 0 0 0 0 5N9F Crystal Structure of Drosophila DHX36 helicase in complex with ssDNA CpG_A 2017-02-24 2018-03-21 Chen, W.-F.,Rety, S.,Hai-Lei Guo, H.-L.,Wu, W.-Q.,Liu, N.-N.,Liu, Q.-W.,Dai, Y.-X.,Xi, X.-G. Structural and mechanistic insights into DHX36-mediated innate immunity and G-quadruplex unfolding To Be Published 0 0 0 0 5X9C Crystal structure of the cytosolic domain of human MiD51 2017-03-06 2018-03-21 Ma, J.,Zhai, Y.,Chen, M.,Zhang, K.,Shi, Y.,Chen, Q.,Pang, X.,Sun, F. New interfaces on MiD51 for Drp1 recruitment and mitochondrial fission regulation To Be Published 0 0 0 0 5YAT 29474823 Crystal structure of mitochondrial alcohol dehydrogenase isozyme III from Komagataella phaffii GS115 2017-09-01 2018-03-21 Zhang, H.,Li, Q.,Wang, L.,Chen, Y. Investigation of structure and function of mitochondrial alcohol dehydrogenase isozyme III from Komagataella phaffii GS115. Biochim. Biophys. Acta 2018 1862 1199 1208 5YIV 29514271 Caulobacter crescentus GcrA DNA-binding domain(DBD) in complex with methylated dsDNA(crystal form 1) 2017-10-06 2018-03-21 Wu, X.,Haakonsen, D.L.,Sanderlin, A.G.,Liu, Y.J.,Shen, L.,Zhuang, N.,Laub, M.T.,Zhang, Y. Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res. 2018 46 3245 3256 5YIW 29514271 Caulobacter crescentus GcrA DNA-binding domain (DBD) in complex with methylated dsDNA (crystal form 2) 2017-10-06 2018-03-21 Wu, X.,Haakonsen, D.L.,Sanderlin, A.G.,Liu, Y.J.,Shen, L.,Zhuang, N.,Laub, M.T.,Zhang, Y. Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res. 2018 46 3245 3256 5Z7I 29514271 Caulobacter crescentus GcrA DNA-binding domain(DBD)in complex with unmethylated dsDNA 2018-01-29 2018-03-21 Wu, X.,Haakonsen, D.L.,Sanderlin, A.G.,Liu, Y.J.,Shen, L.,Zhuang, N.,Laub, M.T.,Zhang, Y. Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res. 2018 46 3245 3256 5XBN crystal structure of Wss1 from saccharomyces cerevisiae 2017-03-20 2018-03-28 Dong, Y.H.,Yang, X.Y. crystal structure of Wss1 from saccharomyces cerevisiae To Be Published 0 0 0 0 5XD6 CARK1 phosphorylates ABA receptors 2017-03-27 2018-04-04 Zhang, L.,Lou, Z. CARK1 phosphorylates ABA receptors To Be Published 0 0 0 0 5XRR 29610493 Crystal structure of FUS (54-59) SYSSYG 2017-06-09 2018-04-04 Luo, F.,Gui, X.,Zhou, H.,Gu, J.,Li, Y.,Liu, X.,Zhao, M.,Li, D.,Li, X.,Liu, C. Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat. Struct. Mol. Biol. 2018 25 341 346 5YP5 29456799 Crystal structure of RORgamma complexed with SRC2 and compound 5d 2017-11-01 2018-04-04 Wang, Y.,Cai, W.,Tang, T.,Liu, Q.,Yang, T.,Yang, L.,Ma, Y.,Zhang, G.,Huang, Y.,Song, X.,Orband-Miller, L.A.,Wu, Q.,Zhou, L.,Xiang, Z.,Xiang, J.N.,Leung, S.,Shao, L.,Lin, X.,Lobera, M.,Ren, F. From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists ACS Med Chem Lett 2018 9 120 124 5YP5 29456799 Crystal structure of RORgamma complexed with SRC2 and compound 5d 2017-11-01 2018-04-04 Wang, Y.,Cai, W.,Tang, T.,Liu, Q.,Yang, T.,Yang, L.,Ma, Y.,Zhang, G.,Huang, Y.,Song, X.,Orband-Miller, L.A.,Wu, Q.,Zhou, L.,Xiang, Z.,Xiang, J.N.,Leung, S.,Shao, L.,Lin, X.,Lobera, M.,Ren, F. From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists ACS Med Chem Lett 2018 9 120 124 5Z2S 29572508 Crystal structure of DUX4-HD2 domain 2018-01-03 2018-04-04 Dong, X.,Zhang, W.,Wu, H.,Huang, J.,Zhang, M.,Wang, P.,Zhang, H.,Chen, Z.,Chen, S.J.,Meng, G. Structural basis of DUX4/IGH-driven transactivation. Leukemia 2018 32 1466 1476 5Z2T 29572508 Crystal structure of DNA-bound DUX4-HD2 2018-01-04 2018-04-04 Dong, X.,Zhang, W.,Wu, H.,Huang, J.,Zhang, M.,Wang, P.,Zhang, H.,Chen, Z.,Chen, S.J.,Meng, G. Structural basis of DUX4/IGH-driven transactivation. Leukemia 2018 32 1466 1476 5YAH 29109411 Crystal 2 for AtLURE1.2-AtPRK6LRR 2017-08-31 2018-04-11 Zhang, X.,Liu, W.,Nagae, T.T.,Takeuchi, H.,Zhang, H.,Han, Z.,Higashiyama, T.,Chai, J. Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun 2017 8 1331 1331 5YAH 29109411 Crystal 2 for AtLURE1.2-AtPRK6LRR 2017-08-31 2018-04-11 Zhang, X.,Liu, W.,Nagae, T.T.,Takeuchi, H.,Zhang, H.,Han, Z.,Higashiyama, T.,Chai, J. Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun 2017 8 1331 1331 5YUF 29599493 Crystal Structure of PML RING tetramer 2017-11-22 2018-04-11 Wang, P.,Benhenda, S.,Wu, H.,Lallemand-Breitenbach, V.,Zhen, T.,Jollivet, F.,Peres, L.,Li, Y.,Chen, S.J.,Chen, Z.,de The, H.,Meng, G. RING tetramerization is required for nuclear body biogenesis and PML sumoylation. Nat Commun 2018 9 1277 1277 5Z1G 29557065 Structure of the Brx1 and Ebp2 complex 2017-12-26 2018-04-11 Zhou, D.,Zhu, X.,Zheng, S.,Tan, D.,Dong, M.Q.,Ye, K. Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate Protein Cell 2019 10 120 130 5ZE3 29581294 Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state 2018-02-25 2018-04-11 Zhang, X.,Wang, Q.,Wu, J.,Wang, J.,Shi, Y.,Liu, M. Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state. Proc. Natl. Acad. Sci. U.S.A. 2018 115 3828 3833 5XPA 28911094 Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 9'U10' on the target strand 2017-06-01 2018-04-18 Sheng, G.,Gogakos, T.,Wang, J.,Zhao, H.,Serganov, A.,Juranek, S.,Tuschl, T.,Patel, D.J.,Wang, Y. Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res. 2017 45 9149 9163 5Y1U 29134516 Crystal structure of RBBP4 bound to AEBP2 RRK motif 2017-07-21 2018-04-18 Sun, A.,Li, F.,Liu, Z.,Jiang, Y.,Zhang, J.,Wu, J.,Shi, Y. Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4 Protein Cell 2017 0 0 0 5YI7 29467404 Crystal structure of drosophila Numb PTB domain and Pon peptide complex 2017-10-03 2018-04-18 Shan, Z.,Tu, Y.,Yang, Y.,Liu, Z.,Zeng, M.,Xu, H.,Long, J.,Zhang, M.,Cai, Y.,Wen, W. Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat Commun 2018 9 737 737 5Z67 29391496 Structure of the recombination mediator protein RecF in RecFOR pathway 2018-01-22 2018-04-18 Tang, Q.,Liu, Y.P.,Shan, H.H.,Tian, L.F.,Zhang, J.Z.,Yan, X.X. ATP-dependent conformational change in ABC-ATPase RecF serves as a switch in DNA repair. Sci Rep 2018 8 2127 2127 5Z68 29391496 Structure of the recombination mediator protein RecF-ATP in RecFOR pathway 2018-01-22 2018-04-18 Tang, Q.,Liu, Y.P.,Shan, H.H.,Tian, L.F.,Zhang, J.Z.,Yan, X.X. ATP-dependent conformational change in ABC-ATPase RecF serves as a switch in DNA repair. Sci Rep 2018 8 2127 2127 5X9B 30703167 Crystal structure of the cytosolic domain of human MiD51 2017-03-06 2018-04-25 Ma, J.,Zhai, Y.,Chen, M.,Zhang, K.,Chen, Q.,Pang, X.,Sun, F. New interfaces on MiD51 for Drp1 recruitment and regulation. Plos One 2019 14 0 0 5XJ3 28978021 Complex structure of ipilimumab-scFv and CTLA-4 2017-04-29 2018-04-25 He, M.,Chai, Y.,Qi, J.,Zhang, C.W.H.,Tong, Z.,Shi, Y.,Yan, J.,Tan, S.,Gao, G.F. Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies Oncotarget 2017 8 67129 67139 5XJ4 28488247 Complex structure of durvalumab-scFv/PD-L1 2017-04-29 2018-04-25 Tan, S.,Liu, K.,Chai, Y.,Zhang, C.W.,Gao, S.,Gao, G.F.,Qi, J. Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab Protein Cell 2018 9 135 139 5XMW 28695844 Selenomethionine-derivated ZHD 2017-05-16 2018-04-25 Qi, Q.,Yang, W.J.,Zhou, H.J.,Ming, D.M.,Sun, K.L.,Xu, T.Y.,Hu, X.J.,Lv, H. The structure of a complex of the lactonohydrolase zearalenone hydrolase with the hydrolysis product of zearalenone at 1.60 angstrom resolution Acta Crystallogr F Struct Biol 2017 73 376 381 5XSR 29335205 novel orally efficacious inhibitors complexed with PARP1 2017-06-15 2018-04-25 Chen, X.,Huan, X.,Liu, Q.,Wang, Y.,He, Q.,Tan, C.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.,Yang, C. Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Eur J Med Chem 2018 145 389 403 5XST 29335205 novel orally efficacious inhibitors complexed with PARP1 2017-06-15 2018-04-25 Chen, X.,Huan, X.,Liu, Q.,Wang, Y.,He, Q.,Tan, C.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.,Yang, C. Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Eur J Med Chem 2018 145 389 403 5XSU 29335205 novel orally efficacious inhibitors complexed with PARP1 2017-06-15 2018-04-25 Chen, X.,Huan, X.,Liu, Q.,Wang, Y.,He, Q.,Tan, C.,Chen, Y.,Ding, J.,Xu, Y.,Miao, Z.,Yang, C. Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors Eur J Med Chem 2018 145 389 403 5XW2 28687492 Crystal structure of the Hydroxylase HmtN in C 1 2 1 crystal form 2017-06-29 2018-04-25 Zhang, H.,Chen, J.,Zhang, H. Molecular characterization of the hydroxylase HmtN at 1.3 angstrom resolution. Biochem. Biophys. Res. Commun. 2017 0 0 0 5ZJV Crystal structure of the catalytic domain of MCR-1 (cMCR-1) in complex with xylose 2018-03-22 2018-04-25 Liu, Z.X.,Han, Z.,Yu, X.L.,Wen, G.,Zeng, C. Crystal Structure of the Catalytic Domain of MCR-1 (cMCR-1) in Complex with d-Xylose Crystals 2018 8 0 0 5XBT 29967320 The structure of BrlR bound to c-di-GMP 2017-03-21 2018-05-02 Wang, F.,He, Q.,Yin, J.,Xu, S.,Hu, W.,Gu, L. BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin. Nat Commun 2018 9 2563 2563 5XBW 29967320 The structure of BrlR 2017-03-21 2018-05-02 Wang, F.,He, Q.,Yin, J.,Xu, S.,Hu, W.,Gu, L. BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin. Nat Commun 2018 9 2563 2563 5XE5 30784195 Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus 2017-04-01 2018-05-02 Han, J.T.,Zhang, S.P.,Jia, W.J.,Zhang, Z.,Wang, Y.,He, Y.X. Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus. FEBS J. 2019 0 0 0 5XEY 30784195 Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus 2017-04-06 2018-05-02 Han, J.T.,Zhang, S.P.,Jia, W.J.,Zhang, Z.,Wang, Y.,He, Y.X. Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus. FEBS J. 2019 0 0 0 5XHY BRD4 bound with compound Bdi1 2017-04-25 2018-05-02 Bing, X. BRD4 bound with compound Bdi1 To Be Published 0 0 0 0 5XI2 BRD4 bound with compound Bdi2 2017-04-25 2018-05-02 Xiong, B.,Cao, D.,Li, Y. BRD4 bound with compound Bdi2 To Be Published 0 0 0 0 5XI3 BRD4 bound with compound Bdi3 2017-04-25 2018-05-02 Xiong, B.,Cao, D.,Li, Y. BRD4 bound with compound Bdi3 To Be Published 0 0 0 0 5XI4 BRD4 bound with compound Bdi4 2017-04-25 2018-05-02 Xiong, B.,Cao, D.,Li, Y. BRD4 bound with compound Bdi4 To Be Published 0 0 0 0 5YMS 29720519 Structural basis of glycan specificity and identification of a novel glycan binding cavity in human P[19] rotavirus 2017-10-22 2018-05-02 Sun, X.,Li, D.,Qi, J.,Chai, W.,Wang, L.,Wang, L.,Peng, R.,Wang, H.,Zhang, Q.,Pang, L.,Kong, X.,Wang, H.,Jin, M.,Gao, G.F.,Duan, Z. Glycan Binding Specificity and Mechanism of Human and Porcine P[6]/P[19] Rotavirus VP8*s. J. Virol. 2018 92 0 0 5YMT 29720519 Functional and structural characterization of P[19] rotavirus VP8* interaction with histo-blood group antigens 2017-10-22 2018-05-02 Sun, X.,Li, D.,Qi, J.,Chai, W.,Wang, L.,Wang, L.,Peng, R.,Wang, H.,Zhang, Q.,Pang, L.,Kong, X.,Wang, H.,Jin, M.,Gao, G.F.,Duan, Z. Glycan Binding Specificity and Mechanism of Human and Porcine P[6]/P[19] Rotavirus VP8*s. J. Virol. 2018 92 0 0 5XKC 29497411 Crystal structure of dibenzothiophene sulfone monooxygenase BdsA at 2.2 angstrome 2017-05-07 2018-05-09 Su, T.,Su, J.,Liu, S.,Zhang, C.,He, J.,Huang, Y.,Xu, S.,Gu, L. Structural and Biochemical Characterization of BdsA fromBacillus subtilisWU-S2B, a Key Enzyme in the ""4S"" Desulfurization Pathway. Front Microbiol 2018 9 231 231 5XKD 29497411 Crystal structure of dibenzothiophene sulfone monooxygenase BdsA in complex with FMN at 2.4 angstrom 2017-05-07 2018-05-09 Su, T.,Su, J.,Liu, S.,Zhang, C.,He, J.,Huang, Y.,Xu, S.,Gu, L. Structural and Biochemical Characterization of BdsA fromBacillus subtilisWU-S2B, a Key Enzyme in the ""4S"" Desulfurization Pathway. Front Microbiol 2018 9 231 231 5YO3 29039033 Crystal Structure of B562RIL with engineered disulfide bond V16C-A29C 2017-10-26 2018-05-09 Pu, M.,Xu, Z.,Peng, Y.,Hou, Y.,Liu, D.,Wang, Y.,Liu, H.,Song, G.,Liu, Z.J. Protein crystal quality oriented disulfide bond engineering. Protein Cell 2018 9 659 663 5XLL 28712808 Dimer form of M. tuberculosis PknI sensor domain 2017-05-10 2018-05-16 Yan, Q.,Jiang, D.,Qian, L.,Zhang, Q.,Zhang, W.,Zhou, W.,Mi, K.,Guddat, L.,Yang, H.,Rao, Z. Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain. Structure 2017 25 1286 0 5XMD Crystal structure of epoxide hydrolase VrEH1 from Vigna radiata 2017-05-14 2018-05-16 Kong, X.D.,Xu, J.H.,Zhou, J.H. Crystal structure of Carboxyl reductase to be published 0 0 0 0 5ZT1 30013545 Structure of the bacterial pathogens ATPase with substrate ATP gamma S 2018-05-01 2018-05-16 Gao, X.,Mu, Z.,Yu, X.,Qin, B.,Wojdyla, J.,Wang, M.,Cui, S. Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase FromShigella flexneri Front Microbiol 2018 9 1468 1468 5XYZ 28945083 The structure of human BTK kinase domain in complex with a covalent inhibitor 2017-07-11 2018-05-23 Wang, Y.,Sun, Y.,Cao, R.,Liu, D.,Xie, Y.,Li, L.,Qi, X.,Huang, N. In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem. 2017 60 8552 8564 5YIQ 29867141 Crystal structure of AnkG LIR/LC3B complex 2017-10-06 2018-05-23 Li, J.,Zhu, R.,Chen, K.,Zheng, H.,Zhao, H.,Yuan, C.,Zhang, H.,Wang, C.,Zhang, M. Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins. Nat. Chem. Biol. 2018 14 778 787 5YIS 29867141 Crystal Structure of AnkB LIR/LC3B complex 2017-10-06 2018-05-23 Li, J.,Zhu, R.,Chen, K.,Zheng, H.,Zhao, H.,Yuan, C.,Zhang, H.,Wang, C.,Zhang, M. Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins. Nat. Chem. Biol. 2018 14 778 787 5YLY 29371148 Crystal structure of the cytochrome b5 reductase domain of Ulva prolifera nitrate reductase 2017-10-20 2018-05-23 You, C.,Liu, C.,Li, Y.,Jiang, P.,Ma, Q. Structural and enzymatic analysis of the cytochrome b5reductase domain of Ulva prolifera nitrate reductase. Int. J. Biol. Macromol. 2018 111 1175 1182 5YMU 29720519 Functional and structural characterization of P[19] rotavirus VP8* interaction with histo-blood group antigens 2017-10-22 2018-05-23 Sun, X.,Li, D.,Qi, J.,Chai, W.,Wang, L.,Wang, L.,Peng, R.,Wang, H.,Zhang, Q.,Pang, L.,Kong, X.,Wang, H.,Jin, M.,Gao, G.F.,Duan, Z. Glycan Binding Specificity and Mechanism of Human and Porcine P[6]/P[19] Rotavirus VP8*s. J. Virol. 2018 92 0 0 5ZJL Crystal Structure of the dust mite allergen Der f 23 from Dermatophagoides farinae 2018-03-20 2018-05-23 Ji, K.,Chen, J.,Sun, J.L.,Hu, J.,Cai, Z. Crystal Structure of the dust mite allergen Der f 23 from Dermatophagoides farinae To Be Published 0 0 0 0 5XO0 28647364 Crystal structure of the isochorismatase domain of AngB from Vibrio anguillarum 775 2017-05-25 2018-05-30 Du, J.,Deng, T.,Ma, Q. Crystal structures of the isochorismatase domains from Vibrio anguillarum. Biochem.Biophys.Res.Commun. 2017 490 827 833 5XO1 28647364 Crystal structure of the isochorismatase domain of VabB from Vibrio anguillarum 775 2017-05-25 2018-05-30 Du, J.,Deng, T.,Ma, Q. Crystal structures of the isochorismatase domains from Vibrio anguillarum. Biochem.Biophys.Res.Commun. 2017 490 827 833 5YIJ 29795342 Structure of a Legionella effector with substrates 2017-10-05 2018-05-30 Dong, Y.,Mu, Y.,Xie, Y.,Zhang, Y.,Han, Y.,Zhou, Y.,Wang, W.,Liu, Z.,Wu, M.,Wang, H.,Pan, M.,Xu, N.,Xu, C.Q.,Yang, M.,Fan, S.,Deng, H.,Tan, T.,Liu, X.,Liu, L.,Li, J.,Wang, J.,Fang, X.,Feng, Y. Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature 2018 557 674 678 5YIK 29795342 Structure of a Legionella effector with its substrate 2017-10-05 2018-05-30 Dong, Y.,Mu, Y.,Xie, Y.,Zhang, Y.,Han, Y.,Zhou, Y.,Wang, W.,Liu, Z.,Wu, M.,Wang, H.,Pan, M.,Xu, N.,Xu, C.Q.,Yang, M.,Fan, S.,Deng, H.,Tan, T.,Liu, X.,Liu, L.,Li, J.,Wang, J.,Fang, X.,Feng, Y. Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature 2018 557 674 678 5YIM 29795342 Structure of a Legionella effector 2017-10-05 2018-05-30 Dong, Y.,Mu, Y.,Xie, Y.,Zhang, Y.,Han, Y.,Zhou, Y.,Wang, W.,Liu, Z.,Wu, M.,Wang, H.,Pan, M.,Xu, N.,Xu, C.Q.,Yang, M.,Fan, S.,Deng, H.,Tan, T.,Liu, X.,Liu, L.,Li, J.,Wang, J.,Fang, X.,Feng, Y. Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature 2018 557 674 678 5YJL 29785497 Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with NADPH and GBP 2017-10-11 2018-05-30 Zhao, A.,Han, F. Crystal structure of Arabidopsis thaliana glutamyl-tRNAGlureductase in complex with NADPH and glutamyl-tRNAGlureductase binding protein Photosyn. Res. 2018 137 443 452 5Z5Y Crystal structure of ConA-R4M 2018-01-22 2018-05-30 Hu, R.T.,Yang, G.,Ding, H.M.,Ma, J.B.,Ma, Y.Q.,Gan, J.H.,Chen, G.S. Competition between Supramolecular Interaction and Protein-Protein Interaction in Protein Crystallization:Effects of Crystallization Method and Small Molecular Bridge Ind Eng Chem Res 2018 57 6726 6733 5Z73 29578606 Crystal structure of alkaline/neutral invertase InvB from Anabaena sp. PCC 7120 2018-01-27 2018-05-30 Xie, J.,Hu, H.X.,Cai, K.,Xia, L.Y.,Yang, F.,Jiang, Y.L.,Chen, Y.,Zhou, C.Z. Structural and enzymatic analyses of Anabaena heterocyst-specific alkaline invertase InvB. FEBS Lett. 2018 592 1589 1601 5Z74 29578606 Crystal structure of alkaline/neutral invertase InvB from Anabaena sp. PCC 7120 complexed with sucrose 2018-01-27 2018-05-30 Xie, J.,Hu, H.X.,Cai, K.,Xia, L.Y.,Yang, F.,Jiang, Y.L.,Chen, Y.,Zhou, C.Z. Structural and enzymatic analyses of Anabaena heterocyst-specific alkaline invertase InvB. FEBS Lett. 2018 592 1589 1601 5ZAC Crystal structure of ConA-R2M 2018-02-07 2018-05-30 Hu, R.T.,Yang, G.,Ding, H.M.,Ma, J.B.,Ma, Y.Q.,Gan, J.H.,Chen, G.S. Competition between Supramolecular Interaction and Protein-Protein Interaction in Protein Crystallization:Effects of Crystallization Method and Small Molecular Bridge Ind Eng Chem Res 2018 57 6726 6733 5ZBR 29752968 Crystal Structure of Kinesin-3 KIF13B motor domain in AMPPNP form 2018-02-12 2018-05-30 Ren, J.,Zhang, Y.,Wang, S.,Huo, L.,Lou, J.,Feng, W. Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. J. Mol. Biol. 2018 430 2030 2041 5ZBS 29752968 Crystal Structure of Kinesin-3 KIF13B motor Y73C mutant 2018-02-12 2018-05-30 Ren, J.,Zhang, Y.,Wang, S.,Huo, L.,Lou, J.,Feng, W. Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. J. Mol. Biol. 2018 430 2030 2041 5ZRX 29749928 Crystal Structure of EphA2/SHIP2 Complex 2018-04-25 2018-05-30 Wang, Y.,Shang, Y.,Li, J.,Chen, W.,Li, G.,Wan, J.,Liu, W.,Zhang, M. Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife 2018 7 0 0 5ZRY 29749928 Crystal Structure of EphA6/Odin Complex 2018-04-25 2018-05-30 Wang, Y.,Shang, Y.,Li, J.,Chen, W.,Li, G.,Wan, J.,Liu, W.,Zhang, M. Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife 2018 7 0 0 5ZRZ 29749928 Crystal Structure of EphA5/SAMD5 Complex 2018-04-25 2018-05-30 Wang, Y.,Shang, Y.,Li, J.,Chen, W.,Li, G.,Wan, J.,Liu, W.,Zhang, M. Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife 2018 7 0 0 5ZT3 29775612 Crystal structure of WA352 from Oryza sativa 2018-05-01 2018-05-30 Wang, X.,Guan, Z.,Gong, Z.,Yan, J.,Yang, G.,Liu, Y.G.,Yin, P. Crystal structure of WA352 provides insight into cytoplasmic male sterility in rice Biochem. Biophys. Res. Commun. 2018 501 898 904 5ZUT Crystal Structure of Yeast PCNA in Complex with N24 Peptide 2018-05-08 2018-05-30 Cheng, X.Y.,Kuang, X.L.,Zhou, Y.,Xia, X.M.,SU, Z.D. Crystal Structure of Yeast PCNA in Complex with N24 Peptide To Be Published 0 0 0 0 5Y12 29775936 Crystal structure of human FABP4 complexed with ligand 5-((4-methoxynaphthalene)-1-sulfonamido)pentanoic acid 2017-07-19 2018-06-06 Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X. From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 Eur J Med Chem 2018 154 44 59 5Y13 29775936 Crystal structure of human FABP4 complexed with ligand 5-((4-bromonaphthalene)-1-sulfonamido)pentanoic acid 2017-07-19 2018-06-06 Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X. From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 Eur J Med Chem 2018 154 44 59 5YGU 29931175 Crystal structure of Escherichia coli (strain K12) mRNA Decapping Complex RppH-DapF 2017-09-27 2018-06-06 Wang, Q.,Zhang, D.,Guan, Z.,Li, D.,Pei, K.,Liu, J.,Zou, T.,Yin, P. DapF stabilizes the substrate-favoring conformation of RppH to stimulate its RNA-pyrophosphohydrolase activity in Escherichia coli. Nucleic Acids Res. 2018 46 6880 6892 5Z78 29844495 Structure of TIRR/53BP1 complex 2018-01-27 2018-06-06 Dai, Y.,Zhang, A.,Shan, S.,Gong, Z.,Zhou, Z. Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR Nat Commun 2018 9 2123 2123 5XGL 28585176 Co-crystal structure of Ac-AChBPP in complex with alpha-conotoxin LvIA 2017-04-14 2018-06-13 Xu, M.,Zhu, X.,Yu, J.,Yu, J.,Luo, S.,Wang, X. The crystal structure of Ac-AChBP in complex with alpha-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes Protein Cell 2017 8 675 685 5Y8W 29566488 Crystal Structure Analysis of the BRD4 2017-08-21 2018-06-13 Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem. 2018 61 3037 3058 5YAN 29844169 Deconstructing the Salt-Bridge Network of a Computationally Designed Collagen Heterotrimer 2017-09-01 2018-06-13 Zheng, H.,Lu, C.,Lan, J.,Fan, S.,Nanda, V.,Xu, F. How electrostatic networks modulate specificity and stability of collagen. Proc. Natl. Acad. Sci. U.S.A. 2018 115 6207 6212 5YM6 29925659 Crystal Structure of porcine delta coronavirus nsp9 2017-10-21 2018-06-13 Zeng, Z.,Deng, F.,Shi, K.,Ye, G.,Wang, G.,Fang, L.,Xiao, S.,Fu, Z.,Peng, G. Dimerization of Coronavirus nsp9 with Diverse Modes Enhances Its Nucleic Acid Binding Affinity. J.Virol. 2018 92 0 0 5YM8 29925659 Crystal Structure of porcine delta coronavirus nsp9-N7 2017-10-21 2018-06-13 Zeng, Z.,Deng, F.,Shi, K.,Ye, G.,Wang, G.,Fang, L.,Xiao, S.,Fu, Z.,Peng, G. Dimerization of Coronavirus nsp9 with Diverse Modes Enhances Its Nucleic Acid Binding Affinity. J.Virol. 2018 92 0 0 5YWW 29846688 Archael RuvB-like Holiday junction helicase 2017-11-30 2018-06-13 Zhai, B.,DuPrez, K.,Han, X.,Yuan, Z.,Ahmad, S.,Xu, C.,Gu, L.,Ni, J.,Fan, L.,Shen, Y. The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. Nucleic Acids Res. 2018 46 6627 6641 5YWW 29846688 Archael RuvB-like Holiday junction helicase 2017-11-30 2018-06-13 Zhai, B.,DuPrez, K.,Han, X.,Yuan, Z.,Ahmad, S.,Xu, C.,Gu, L.,Ni, J.,Fan, L.,Shen, Y. The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. Nucleic Acids Res. 2018 46 6627 6641 5XOE 29940104 Crystal Structure of the apo Staphylococcus aureus phosphofructokinase 2017-05-27 2018-06-20 Tian, T.,Wang, C.,Wu, M.,Zhang, X.,Zang, J. Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion. Biochemistry 2018 57 4252 4262 5XQD Crystal structure of Human Hsp90 with FS2 2017-06-07 2018-06-20 Li, J.,Shi, F.,Xiong, B.,He, J.H. Crystal structure of Human Hsp90 with FS2 To Be Published 0 0 0 0 5XQE Crystal structure of Human Hsp90 with FS3 2017-06-07 2018-06-20 Li, J.,Shi, F.,Xiong, B.,He, J.H. Crystal structure of Human Hsp90 with FS3 To Be Published 0 0 0 0 5XR5 Crystal structure of Human Hsp90 with FS4 2017-06-07 2018-06-20 Li, J.,Shi, F.,Xiong, B.,He, J.H. Crystal structure of Human Hsp90 with FS4 To Be Published 0 0 0 0 5XR9 Crystal structure of Human Hsp90 with FS6 2017-06-08 2018-06-20 Li, J.,Shi, F.,Xiong, B.,He, J.H. Crystal structure of Human Hsp90 with FS6 To Be Published 0 0 0 0 5XYV 29858487 Crystal structure of drosophila melanogaster Rhino chromoshadow domain in complex with Deadlock N-terminal domain 2017-07-10 2018-06-20 Yu, B.,Lin, Y.A.,Parhad, S.S.,Jin, Z.,Ma, J.,Theurkauf, W.E.,Zhang, Z.Z.,Huang, Y. Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification EMBO Rep. 2018 19 0 0 5YBH 30013545 Structural of the highly conserved ATPase from type III secretion system of bacterial pathogens 2017-09-05 2018-06-20 Gao, X.,Mu, Z.,Yu, X.,Qin, B.,Wojdyla, J.,Wang, M.,Cui, S. Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase FromShigella flexneri Front Microbiol 2018 9 1468 1468 5YLI 29871927 Complex structure of GH113 beta-1,4-mannanase 2017-10-17 2018-06-20 You, X.,Qin, Z.,Yan, Q.,Yang, S.,Li, Y.,Jiang, Z. Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase from Amphibacillus xylanus J. Biol. Chem. 2018 293 11746 11757 5YLK 29871927 Complex structure of GH 113 family beta-1,4-mannanase with mannobiose 2017-10-17 2018-06-20 You, X.,Qin, Z.,Yan, Q.,Yang, S.,Li, Y.,Jiang, Z. Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase fromn Amphibacillus xylanus J. Biol. Chem. 2018 293 11746 11757 5YLL 29871927 Structure of GH113 beta-1,4-mannanase complex with M6. 2017-10-17 2018-06-20 You, X.,Qin, Z.,Yan, Q.,Yang, S.,Li, Y.,Jiang, Z. Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase from Amphibacillus xylanus J. Biol. Chem. 2018 293 11746 11757 5Z4T 29871927 Complex structure - AxMan113A-M3 2018-01-13 2018-06-20 You, X.,Qin, Z.,Yan, Q.,Yang, S.,Li, Y.,Jiang, Z. Structural insights into the catalytic mechanism of a novel glycoside hydrolase family 113 beta-1,4-mannanase fromAmphibacillus xylanus J. Biol. Chem. 2018 293 11746 11757 5Z5K 29503192 Structure of the DCC-Draxin complex 2018-01-18 2018-06-20 Liu, Y.,Bhowmick, T.,Liu, Y.,Gao, X.,Mertens, H.D.T.,Svergun, D.I.,Xiao, J.,Zhang, Y.,Wang, J.H.,Meijers, R. Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. Neuron 2018 97 1261 0 5ZK1 29733854 Crystal Structure of the CRTC2(SeMet)-CREB-CRE complex 2018-03-22 2018-06-20 Song, Y.,Zhai, L.,Valencia Swain, J.,Chen, Y.,Wang, P.,Chen, L.,Liu, Y.,Xiang, S. Structural Insights into the CRTC2-CREB Complex Assembly on CRE. J. Mol. Biol. 2018 430 1926 1939 5ZKO 29733854 Crystal structure of the CRTC2-CREB-CRE complex 2018-03-24 2018-06-20 Song, Y.,Zhai, L.,Valencia Swain, J.,Chen, Y.,Wang, P.,Chen, L.,Liu, Y.,Xiang, S. Structural Insights into the CRTC2-CREB Complex Assembly on CRE. J. Mol. Biol. 2018 430 1926 1939 6A0X 29925655 Crystal structure of broadly neutralizing antibody 13D4 2018-06-06 2018-06-20 Lin, Q.,Li, T.,Chen, Y.,Lau, S.Y.,Wei, M.,Zhang, Y.,Zhang, Z.,Yao, Q.,Li, J.,Li, Z.,Wang, D.,Zheng, Q.,Yu, H.,Gu, Y.,Zhang, J.,Chen, H.,Li, S.,Xia, N. Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J. Virol. 2018 92 0 0 6A0Z 29925655 Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA head region 2018-06-06 2018-06-20 Lin, Q.,Li, T.,Chen, Y.,Lau, S.Y.,Wei, M.,Zhang, Y.,Zhang, Z.,Yao, Q.,Li, J.,Li, Z.,Wang, D.,Zheng, Q.,Yu, H.,Gu, Y.,Zhang, J.,Chen, H.,Li, S.,Xia, N. Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J. Virol. 2018 92 0 0 5XTT 29550433 Crystal structure of RmMan134A-M3 complex 2017-06-20 2018-06-27 You, X.,Qin, Z.,Li, Y.X.,Yan, Q.J.,Li, B.,Jiang, Z.Q. Structural and biochemical insights into the substrate-binding mechanism of a novel glycoside hydrolase family 134 beta-mannanase. Biochim Biophys Acta Gen Subj 2018 1862 1376 1388 5XTZ 29900004 Crystal structure of GAS41 YEATS bound to H3K27ac peptide 2017-06-21 2018-06-27 Hsu, C.C.,Zhao, D.,Shi, J.,Peng, D.,Guan, H.,Li, Y.,Huang, Y.,Wen, H.,Li, W.,Li, H.,Shi, X. Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. Cell Discov 2018 4 28 28 5XU7 Crystal structure of Escherichia coli holo-[acyl-carrier-protein] synthase (AcpS) 2017-06-22 2018-06-27 Liao, Y.P.,Wang, D.L.,Yin, D.P.,Zhang, Q.Y.,Wang, Y.M.,Wang, D.Q.,Zhu, H.X.,Chen, S. Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria To Be Published 0 0 0 0 5XUA 31177588 The ligand-free dimer of chemoreceptor MCP2201 ligand binding domain 2017-06-23 2018-06-27 Hong, Y.,Huang, Z.,Guo, L.,Ni, B.,Jiang, C.Y.,Li, X.J.,Hou, Y.J.,Yang, W.S.,Wang, D.C.,Zhulin, I.B.,Liu, S.J.,Li, D.F. The ligand-binding domain of a chemoreceptor from Comamonas testosteroni has a previously unknown homotrimeric structure. Mol.Microbiol. 2019 0 0 0 5XUB 31177588 The citrate-bound trimer of chemoreceptor MCP2201 ligand binding domain 2017-06-23 2018-06-27 Hong, Y.,Huang, Z.,Guo, L.,Ni, B.,Jiang, C.Y.,Li, X.J.,Hou, Y.J.,Yang, W.S.,Wang, D.C.,Zhulin, I.B.,Liu, S.J.,Li, D.F. The ligand-binding domain of a chemoreceptor from Comamonas testosteroni has a previously unknown homotrimeric structure. Mol.Microbiol. 2019 0 0 0 5XUH Crystal structure of Escherichia coli holo-[acyl-carrier-protein] synthase (AcpS) D9A mutant in complex with CoA 2017-06-23 2018-06-27 Liao, Y.P.,Wang, D.L.,Yin, D.P.,Zhang, Q.Y.,Wang, Y.M.,Wang, D.Q.,Zhu, H.X.,Chen, S. Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria To Be Published 0 0 0 0 5XUK Crystal structure of Helicobacter pylori holo-[acyl-carrier-protein] synthase (AcpS) in complex with coenzyme A 2017-06-23 2018-06-27 Liao, Y.P.,Wang, D.L.,Yin, D.P.,Zhang, Q.Y.,Wang, Y.M.,Wang, D.Q.,Zhu, H.X.,Chen, S. Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria To Be Published 0 0 0 0 5XUM Crystal structure of Thermotoga maritima holo-[acyl-carrier-protein] synthase (AcpS) 2017-06-23 2018-06-27 Liao, Y.P.,Wang, D.L.,Yin, D.P.,Zhang, Q.Y.,Wang, Y.M.,Wang, D.Q.,Zhu, H.X.,Chen, S. Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria To Be Published 0 0 0 0 5Z9Z 30181559 The C-terminal RRM domain of Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 (E329A/E330A/E332A) 2018-02-05 2018-06-27 Chen, J.,Liu, L.,You, C.,Gu, J.,Ruan, W.,Zhang, L.,Gan, J.,Cao, C.,Huang, Y.,Chen, X.,Ma, J. Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun 2018 9 3585 3585 5ZCJ Crystal structure of complex 2018-02-17 2018-06-27 Wang, J.,Yuan, Z.,Cui, Y.,Xie, R.,Wang, M.,Ma, Y.,Yu, X.,Liu, X. Crystal structure of complex To Be Published 0 0 0 0 5XJT Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2.R61A/F/E/G from Human 2017-05-04 2018-07-04 Yi, H.,Zhang, R. Structures of 7S mutant complexes To Be Published 0 0 0 0 5XRB Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 2017-06-08 2018-07-04 Li, J.,Shi, F.,Xiong, B.,He, J.H. Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 To Be Published 0 0 0 0 5XRE Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1 2017-06-08 2018-07-04 Li, J.,Shi, F.,Xiong, B.,He, J.H. Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1 To Be Published 0 0 0 0 5YA5 29202410 CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR 2017-08-30 2018-07-04 Yuan, H.,Liu, Q.,Zhang, L.,Hu, S.,Chen, T.,Li, H.,Chen, Y.,Xu, Y.,Lu, T. Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors Eur J Med Chem 2018 143 491 502 5YPT 29428820 Crystal structure of Marchantia paleacea chalone synthase like 1 (CHSL1) 2017-11-03 2018-07-04 Yu, H.N.,Liu, X.Y.,Gao, S.,Sun, B.,Zheng, H.B.,Ji, M.,Cheng, A.X.,Lou, H.X. Structural and biochemical characterization of the plant type III polyketide synthases of the liverwort Marchantia paleacea. Plant Physiol. Biochem. 2018 125 95 105 5WXF 29959058 Crystal structure of uPA in complex with upain-2-2 2017-01-07 2018-07-11 Jiang, L.,Oldenburg, E.,Kromann-Hansen, T.,Xu, P.,Jensen, J.K.,Andreasen, P.A.,Huang, M. Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Biochim. Biophys. Acta 2018 1862 2017 2023 5WXO 29959058 Crystal structure of uPA in complex with upain-2-2-W3A 2017-01-08 2018-07-11 Jiang, L.,Oldenburg, E.,Kromann-Hansen, T.,Xu, P.,Jensen, J.K.,Andreasen, P.A.,Huang, M. Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Biochim. Biophys. Acta 2018 1862 2017 2023 5WXP 29959058 Crystal structure of uPA in complex with upain-2-3-W3A 2017-01-08 2018-07-11 Jiang, L.,Oldenburg, E.,Kromann-Hansen, T.,Xu, P.,Jensen, J.K.,Andreasen, P.A.,Huang, M. Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Biochim. Biophys. Acta 2018 1862 2017 2023 5XY9 Structure of the MST4 and 14-3-3 complex 2017-07-06 2018-07-11 Shi, Z.,Zhou, Z. Structure of the MST4 and 14-3-3 complex To Be Published 0 0 0 0 5XZ5 Purification,crystallization and structural analysis of cytoplastic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae 2017-07-11 2018-07-11 Zhou, P.F. Purification,crystallization and structural analysis of cytoplastic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae To Be Published 0 0 0 0 5Y82 29295859 Crystal structure of the periplasmic domain of the Thermotoga maritima YidC 2017-08-18 2018-07-11 Xin, Y.,Zhao, Y.,Zheng, J.,Zhou, H.,Zhang, X.C.,Tian, C.,Huang, Y. Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion FASEB J. 2018 32 2411 2421 5Y83 29295859 Crystal structure of YidC from Thermotoga maritima 2017-08-18 2018-07-11 Xin, Y.,Zhao, Y.,Zheng, J.,Zhou, H.,Zhang, X.C.,Tian, C.,Huang, Y. Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion FASEB J. 2018 32 2411 2421 5XZ3 29396863 The X-ray structure of Apis mellifera PGRP-SA 2017-07-11 2018-07-18 Liu, Y.,Zhao, X.,Naeem, M.,An, J. Crystal structure of peptidoglycan recognition protein SA in Apis mellifera (Hymenoptera: Apidae). Protein Sci. 2018 27 893 897 5Y6G 31836667 PilZ domain with c-di-GMP of YcgR from Escherichia coli 2017-08-11 2018-07-18 Hou, Y.J.,Yang, W.S.,Hong, Y.,Zhang, Y.,Wang, D.C.,Li, D.F. Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility inEscherichia coli. J.Biol.Chem. 2020 295 808 821 5ZTN 29987021 The crystal structure of human DYRK2 in complex with Curcumin 2018-05-04 2018-07-18 Banerjee, S.,Ji, C.,Mayfield, J.E.,Goel, A.,Xiao, J.,Dixon, J.E.,Guo, X. Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc. Natl. Acad. Sci. U.S.A. 2018 115 8155 8160 5YE7 29193967 The crystal structure of Lp-PLA2 in complex with a novel inhibitor 2017-09-15 2018-07-25 Liu, Q.,Huang, F.,Yuan, X.,Wang, K.,Zou, Y.,Shen, J.,Xu, Y. Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem. 2017 60 10231 10244 5YE9 29193967 The crystal structure of Lp-PLA2 in complex with a novel inhibitor 2017-09-15 2018-07-25 Liu, Q.,Huang, F.,Yuan, X.,Wang, K.,Zou, Y.,Shen, J.,Xu, Y. Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem. 2017 60 10231 10244 5YEA 29193967 The crystal structure of Lp-PLA2 in complex with a novel inhibitor 2017-09-15 2018-07-25 Liu, Q.,Huang, F.,Yuan, X.,Wang, K.,Zou, Y.,Shen, J.,Xu, Y. Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J. Med. Chem. 2017 60 10231 10244 5Z8N 30082787 Crystal structure of Arabidopsis thaliana EBS C-terminal deletion construct in complex with an H3K4me2 peptide 2018-01-31 2018-07-25 Yang, Z.,Qian, S.,Scheid, R.N.,Lu, L.,Chen, X.,Liu, R.,Du, X.,Lv, X.,Boersma, M.D.,Scalf, M.,Smith, L.M.,Denu, J.M.,Du, J.,Zhong, X. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat. Genet. 2018 50 1247 1253 5ZBB 30057113 Crystal structure of Rtt109-Asf1-H3-H4 complex 2018-02-10 2018-07-25 Zhang, L.,Serra-Cardona, A.,Zhou, H.,Wang, M.,Yang, N.,Zhang, Z.,Xu, R.M. Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109. Cell 2018 174 818 0 5ZXD 30017566 Crystal structure of ATP-bound human ABCF1 2018-05-18 2018-07-25 Qu, L.,Jiang, Y.,Cheng, C.,Wu, D.,Meng, B.,Chen, Z.,Zhu, Y.,Shaw, N.,Ouyang, S.,Liu, Z.J. Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins Structure 2018 26 1259 0 5ZXV 29996104 Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein 2018-05-21 2018-07-25 Zhang, S.,Zhou, P.,Wang, P.,Li, Y.,Jiang, L.,Jia, W.,Wang, H.,Fan, A.,Wang, D.,Shi, X.,Fang, X.,Hammel, M.,Wang, S.,Wang, X.,Zhang, L. Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein Cell Rep 2018 24 441 452 5Y9P 30005877 Staphylococcus aureus RNase HII 2017-08-26 2018-08-01 Hang, T.,Zhang, X.,Wu, M.,Wang, C.,Ling, S.,Xu, L.,Gong, Q.,Tian, C.,Zhang, X.,Zang, J. Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII Biochem. Biophys. Res. Commun. 2018 503 1207 1213 5YF0 29463897 Crystal structure of CARNMT1 bound to SAM 2017-09-20 2018-08-01 Cao, R.,Zhang, X.,Liu, X.,Li, Y.,Li, H. Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res. 2018 28 494 496 5YF1 29463897 Crystal structure of CARNMT1 bound to carnosine and SFG 2017-09-20 2018-08-01 Cao, R.,Zhang, X.,Liu, X.,Li, Y.,Li, H. Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res. 2018 28 494 496 5YF2 29463897 Crystal structure of CARNMT1 bound to anserine and SAH 2017-09-20 2018-08-01 Cao, R.,Zhang, X.,Liu, X.,Li, Y.,Li, H. Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res. 2018 28 494 496 5YY5 29996104 Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein 2017-12-08 2018-08-01 Zhang, S.,Zhou, P.,Wang, P.,Li, Y.,Jiang, L.,Jia, W.,Wang, H.,Fan, A.,Wang, D.,Shi, X.,Fang, X.,Hammel, M.,Wang, S.,Wang, X.,Zhang, L. Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein Cell Rep 2018 24 441 452 5ZOV 30038796 Inward-facing conformation of L-ascorbate transporter UlaA 2018-04-16 2018-08-01 Luo, P.,Dai, S.,Zeng, J.,Duan, J.,Shi, H.,Wang, J. Inward-facing conformation of l-ascorbate transporter suggests an elevator mechanism Cell Discov 2018 4 35 35 5XFJ 30298149 Crystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550M) 2017-04-10 2018-08-08 Wu, D.,Guo, M.,Min, X.,Dai, S.,Li, M.,Tan, S.,Li, G.,Chen, X.,Ma, Y.,Li, J.,Jiang, L.,Qu, L.,Zhou, Z.,Chen, Z.,Chen, L.,Xu, G.,Chen, Y. LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance. Chem. Commun. (Camb.) 2018 54 12089 12092 5XXQ Crystal structure of RBBP4: ZNF827 and its function in telomere 2017-07-04 2018-08-08 Sun, A.,Shi, Y. Crystal structure of RBBP4: ZNF827 and its function in telomere To Be Published 0 0 0 0 5Y2I Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor PGMI-004A 2017-07-26 2018-08-08 Jiang, L.,Zhou, L. Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor PGMI-004A To Be Published 0 0 0 0 5Y2Q X-ray structure of acetylcholine binding protein (AChBP) complexed with a small molecule 2017-07-26 2018-08-08 Jiang, L.L.,Zhou, L. X-ray structure of acetylcholine binding protein (AChBP) complexed with a small molecule To Be Published 0 0 0 0 5Y2U X-ray structure of Phosphoglycerate Mutase 1(PGAM1) complexed with a small molecule 2017-07-27 2018-08-08 Zhou, L.,Jiang, L.L. X-ray structure of Phosphoglycerate Mutase 1(PGAM1) complexed with a small molecule To Be Published 0 0 0 0 5Y51 Crystal structure of PytH_H230A 2017-08-06 2018-08-08 Xu, D.Q.,Ran, T.T.,He, J.,Wang, W.W. Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2 To Be Published 0 0 0 0 5Y57 Crystal structure of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2 2017-08-07 2018-08-08 Xu, D.Q.,Ran, T.T.,He, J.,Wang, W.W. Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2 To Be Published 0 0 0 0 5YSX 29617875 Structure of P domain of GII.2 Noroviruses 2017-11-16 2018-08-08 Ao, Y.,Cong, X.,Jin, M.,Sun, X.,Wei, X.,Wang, J.,Zhang, Q.,Song, J.,Yu, J.,Cui, J.,Qi, J.,Tan, M.,Duan, Z. Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China. J. Infect. Dis. 2018 218 133 143 5YT7 crystal structure of circularly permutated Azurin 3 2017-11-17 2018-08-08 Chen, H.H.,Su, B.,Zhang, T.T.,Huang, A.,Liu, H.P.,Yu, Y.,Wang, J. Engineering the Metal-binding Loop of a Blue Copper Protein by Circular Permutation Rsc Adv 2017 0 56093 56098 5YVF 30012777 Crystal structure of BFA1 2017-11-25 2018-08-08 Zhang, L.,Pu, H.,Duan, Z.,Li, Y.,Liu, B.,Zhang, Q.,Li, W.,Rochaix, J.D.,Liu, L.,Peng, L. Nucleus-Encoded Protein BFA1 Promotes Efficient Assembly of the Chloroplast ATP Synthase Coupling Factor 1. Plant Cell 2018 30 1770 1788 5YYL 30135511 Structure of Major Royal Jelly Protein 1 Oligomer 2017-12-10 2018-08-08 Tian, W.,Li, M.,Guo, H.,Peng, W.,Xue, X.,Hu, Y.,Liu, Y.,Zhao, Y.,Fang, X.,Wang, K.,Li, X.,Tong, Y.,Conlon, M.A.,Wu, W.,Ren, F.,Chen, Z. Architecture of the native major royal jelly protein 1 oligomer. Nat Commun 2018 9 3373 3373 5Z2M 30012887 Structure of Orp1L/Rab7 complex 2018-01-03 2018-08-08 Ma, X.,Liu, K.,Li, J.,Li, H.,Li, J.,Liu, Y.,Yang, C.,Liang, H. A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning. J. Biol. Chem. 2018 293 14155 14164 5ZB1 30096191 Monomeric crystal structure of orf57 from KSHV 2018-02-09 2018-08-08 Yuan, F.,Gao, Z.Q.,Majerciak, V.,Bai, L.,Hu, M.L.,Lin, X.X.,Zheng, Z.M.,Dong, Y.H.,Lan, K. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. PLoS Pathog. 2018 14 0 0 5ZB3 30096191 Dimeric crystal structure of ORF57 from KSHV 2018-02-09 2018-08-08 Yuan, F.,Gao, Z.Q.,Majerciak, V.,Bai, L.,Hu, M.L.,Lin, X.X.,Zheng, Z.M.,Dong, Y.H.,Lan, K. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. PLoS Pathog. 2018 14 0 0 5ZMU 30003205 Crystal structure of a cis-epoxysuccinate hydrolase producing D(-)-tartaric acids 2018-04-06 2018-08-08 Dong, S.,Liu, X.,Cui, G.Z.,Cui, Q.,Wang, X.,Feng, Y. Structural insight into the catalytic mechanism of a cis-epoxysuccinate hydrolase producing enantiomerically pure d(-)-tartaric acid. Chem. Commun. (Camb.) 2018 54 8482 8485 5ZMY 30003205 Crystal structure of a cis-epoxysuccinate hydrolase producing D(-)-tartaric acids 2018-04-06 2018-08-08 Dong, S.,Liu, X.,Cui, G.Z.,Cui, Q.,Wang, X.,Feng, Y. Structural insight into the catalytic mechanism of a cis-epoxysuccinate hydrolase producing enantiomerically pure d(-)-tartaric acid. Chem. Commun. (Camb.) 2018 54 8482 8485 5XYB 30224798 Crystal structure of AimR from Bacillus phage SPbeta 2017-07-07 2018-08-15 Wang, Q.,Guan, Z.,Pei, K.,Wang, J.,Liu, Z.,Yin, P.,Peng, D.,Zou, T. Structural basis of the arbitrium peptide-AimR communication system in the phage lysis-lysogeny decision. Nat Microbiol 2018 3 1266 1273 5Y28 30936204 Crystal structure of H. pylori HtrA with PDZ2 deletion 2017-07-24 2018-08-15 Zhang, Z.,Huang, Q.,Tao, X.,Song, G.,Zheng, P.,Li, H.,Sun, H.,Xia, W. The unique trimeric assembly of the virulence factor HtrA fromHelicobacter pylorioccurs via N-terminal domain swapping. J.Biol.Chem. 2019 294 7990 8000 5Y4T 29524511 Crystal structure of Trx domain of Grx3 from Saccharomyces cerevisiae 2017-08-05 2018-08-15 Chi, C.B.,Tang, Y.,Zhang, J.,Dai, Y.N.,Abdalla, M.,Chen, Y.,Zhou, C.Z. Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3. J.Mol.Biol. 2018 430 1235 1248 5Y4U 29524511 Crystal structure of Grx domain of Grx3 from Saccharomyces cerevisiae 2017-08-05 2018-08-15 Chi, C.B.,Tang, Y.,Zhang, J.,Dai, Y.N.,Abdalla, M.,Chen, Y.,Zhou, C.Z. Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3. J.Mol.Biol. 2018 430 1235 1248 5Y5R Crystal structure of a novel Pyrethroid Hydrolase PytH with BIF 2017-08-09 2018-08-15 Xu, D.Q.,Ran, T.T.,He, J.,Wang, W.W. Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2 To Be Published 0 0 0 0 5ZC3 30077372 The Crystal Structure of PcRxLR12 2018-02-14 2018-08-15 Zhao, L.,Zhang, X.,Zhang, X.,Song, W.,Li, X.,Feng, R.,Yang, C.,Huang, Z.,Zhu, C. Crystal structure of the RxLR effector PcRxLR12 from Phytophthora capsici Biochem. Biophys. Res. Commun. 2018 503 1830 1835 5ZQY 30045870 Crystal structure of a poly(ADP-ribose) glycohydrolase 2018-04-20 2018-08-15 Wang, M.,Yuan, Z.,Xie, R.,Ma, Y.,Liu, X.,Yu, X. Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation. J. Biol. Chem. 2018 293 14470 14480 5ZGE 30150473 Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin 2018-03-08 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGI 30150473 Crystal structure of NDM-1 at pH6.5 (Succinate) with 1 molecule per asymmetric unit 2018-03-09 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGP 30150473 Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGQ 30150473 Crystal structure of NDM-1 at pH7.5 (Tris-HCl, (NH4)2SO4) in complex with hydrolyzed ampicillin 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGR 30150473 Crystal structure of NDM-1 at pH7.3 (HEPES) in complex with hydrolyzed ampicillin 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGT 30150473 Crystal structure of NDM-1 at pH7.5 (HEPES) with 2 molecules per asymmetric unit 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGU 30150473 Crystal structure of NDM-1 at pH7.0 (HEPES) with 2 molecules per asymmetric unit 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGV 30150473 Crystal structure of NDM-1 at pH8.0 (Tris) with 2 molecules per asymmetric unit 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGW 30150473 Crystal structure of NDM-1 at pH7.5 with 1 molecule per asymmetric unit (crystallized at succinate pH5.5 and soaked at succinate pH7.5) 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGX 30150473 Crystal structure of NDM-1 at pH7.5 (Succinate) with 1 molecule per asymmetric unit 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGY 30150473 Crystal structure of NDM-1 at pH7.5 (Bis-Tris) with 1 molecule per asymmetric unit 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZGZ 30150473 Crystal structure of NDM-1 at pH7.5 (Imidazole) with 1 molecule per asymmetric unit 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZH1 30150473 Crystal structure of NDM-1 at pH7.5 (Imidazole) with 2 molecules per asymmetric unit 2018-03-10 2018-08-22 Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q. Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother. 2018 62 0 0 5ZXF The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a 2018-05-19 2018-08-22 Cheng, X.Y.,Su, Z.D. The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a To Be Published 0 0 0 0 6AOG Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine) 2017-08-16 2018-08-22 Thomas, S.B.,Hopper, A. Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published 0 0 0 0 6AOH Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533) 2017-08-16 2018-08-22 Thomas, S.B.,Hopper, A. Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published 0 0 0 0 6AOI Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine (TRC-2528) 2017-08-16 2018-08-22 Thomas, S.B.,Hopper, A. Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published 0 0 0 0 5XQZ 28947795 Structure of the MOB1-NDR2 complex 2017-06-07 2018-08-29 Kulaberoglu, Y.,Lin, K.,Holder, M.,Gai, Z.,Gomez, M.,Assefa Shifa, B.,Mavis, M.,Hoa, L.,Sharif, A.A.D.,Lujan, C.,Smith, E.S.J.,Bjedov, I.,Tapon, N.,Wu, G.,Hergovich, A. Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nat Commun 2017 8 695 695 5XX0 30150416 Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein 2017-06-30 2018-08-29 Tang, H.,Chang, H.,Dong, Y.,Guo, L.,Shi, X.,Wu, Y.,Huang, Y.,He, Y. Architecture of cell-cell adhesion mediated by sidekicks. Proc. Natl. Acad. Sci. U.S.A. 2018 115 9246 9251 6A5K 30150382 Crystal structure of Arabidopsis thaliana SUVH6 in complex with SAM, form 1 2018-06-24 2018-08-29 Li, X.,Harris, C.J.,Zhong, Z.,Chen, W.,Liu, R.,Jia, B.,Wang, Z.,Li, S.,Jacobsen, S.E.,Du, J. Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 2018 115 0 0 6A5M 30150382 Crystal structure of Arabidopsis thaliana SUVH6 in complex with SAM, form 2 2018-06-24 2018-08-29 Li, X.,Harris, C.J.,Zhong, Z.,Chen, W.,Liu, R.,Jia, B.,Wang, Z.,Li, S.,Jacobsen, S.E.,Du, J. Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 2018 115 0 0 6A67 30154240 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody FLD21.140 2018-06-26 2018-08-29 Zuo, Y.,Wang, P.,Sun, J.,Guo, S.,Wang, G.,Zuo, T.,Fan, S.,Zhou, P.,Liang, M.,Shi, X.,Wang, X.,Zhang, L. Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies. J. Biol. Chem. 2018 293 16503 16517 5XFF 30298149 Crystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550L) 2017-04-10 2018-09-05 Wu, D.,Guo, M.,Min, X.,Dai, S.,Li, M.,Tan, S.,Li, G.,Chen, X.,Ma, Y.,Li, J.,Jiang, L.,Qu, L.,Zhou, Z.,Chen, Z.,Chen, L.,Xu, G.,Chen, Y. LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance. Chem. Commun. (Camb.) 2018 54 12089 12092 5XM6 the overall structure of VrEH2 2017-05-12 2018-09-05 Li, F.L.,Kong, X.D.,Chen, Q.,Zheng, Y.C.,Xu, Q.,Chen, F.F.,Fan, L.Q.,Lin, G.Q.,Zhou, J.H.,Yu, H.L.,Xu, J.H. Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation Acs Catalysis 2018 8 8314 8317 5YAV Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction 2017-09-01 2018-09-05 Bing, X.,Yanlian, L.,Danyan, C. Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction To Be Published 0 0 0 0 5YAW Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction 2017-09-01 2018-09-05 Bing, X.,Yanlian, L.,Danyan, C. Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction To Be Published 0 0 0 0 5YB1 29722993 Structure and function of human serum albumin-metal agent complex 2017-09-02 2018-09-05 Wang, J.,Gou, Y.,Zhang, Z.,Yu, P.,Qi, J.,Qin, Q.,Sun, H.,Wu, X.,Liang, H.,Yang, F. Developing an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin. Mol. Pharm. 2018 15 2180 2193 6ADG 30131249 Crystal Structures of IDH1 R132H in complex with AG-881 2018-08-01 2018-09-05 Ma, R.,Yun, C.H. Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2 Biochem. Biophys. Res. Commun. 2018 503 2912 2917 6AGG 30121296 Crystal structure of agmatine-AMPPCP-Mg complexed TiaS (tRNAIle2 agmatidine synthetase) 2018-08-11 2018-09-05 Dong, J.,Li, F.,Gao, F.,Wei, J.,Lin, Y.,Zhang, Y.,Lou, J.,Liu, G.,Dong, Y.,Liu, L.,Liu, H.,Wang, J.,Gong, W. Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon. J. Mol. Biol. 2018 430 4183 4194 6DFY 30054554 Remodeled crystal structure of DNA-bound DUX4-HD2 2018-05-15 2018-09-05 Aihara, H.,Shi, K.,Lee, J.K.,Bosnakovski, D.,Kyba, M. Comment on structural basis of DUX4/IGH-driven transactivation. Leukemia 2018 32 2090 2092 6A0N 30071124 The crystal structure of apo-Lpg2622 2018-06-05 2018-09-12 Gong, X.,Zhao, X.,Zhang, W.,Wang, J.,Chen, X.,Hameed, M.F.,Zhang, N.,Ge, H. Structural characterization of the hypothetical protein Lpg2622, a new member of the C1 family peptidases from Legionella pneumophila FEBS Lett. 2018 592 2798 2810 6A0Q 30071124 The crystal structure of Lpg2622_E64 complex 2018-06-06 2018-09-12 Gong, X.,Zhao, X.,Zhang, W.,Wang, J.,Chen, X.,Hameed, M.F.,Zhang, N.,Ge, H. Structural characterization of the hypothetical protein Lpg2622, a new member of the C1 family peptidases from Legionella pneumophila FEBS Lett. 2018 592 2798 2810 5XZ4 30510067 The X-tay structure of Bumblebee PGRP-SA 2017-07-11 2018-09-19 Liu, Y.J.,Zhao, X.M.,Huang, J.X.,Chen, M.M.,An, J.D. Structural Insights into the Preferential Binding of PGRP-SAs from Bumblebees and Honeybees to Dap-Type Peptidoglycans Rather than Lys-Type Peptidoglycans. J Immunol. 2019 202 249 259 5Y24 30224798 Crystal structure of AimR from Bacillus phage SPbeta in complex with its signalling peptide 2017-07-24 2018-09-19 Wang, Q.,Guan, Z.,Pei, K.,Wang, J.,Liu, Z.,Yin, P.,Peng, D.,Zou, T. Structural basis of the arbitrium peptide-AimR communication system in the phage lysis-lysogeny decision. Nat Microbiol 2018 3 1266 1273 5YEV 30941855 Murine DR3 death domain 2017-09-19 2018-09-19 Yin, X.,Li, W.,Ma, H.,Zeng, W.,Peng, C.,Li, Y.,Liu, M.,Chen, Q.,Zhou, R.,Jin, T. Crystal structure and activation mechanism of DR3 death domain. Febs J. 2019 286 2593 2610 5YF5 30239956 Crystals structure of Classical swine fever virus NS5B (residues 1-694) 2017-09-20 2018-09-19 Liu, W.,Shi, X.,Gong, P. A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2018 46 10840 10854 5YF6 30239956 Crystals structure of Classical swine fever virus NS5B (residues 1-682) 2017-09-20 2018-09-19 Liu, W.,Shi, X.,Gong, P. A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2018 46 10840 10854 5YF8 30239956 Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A-E472A mutant) 2017-09-20 2018-09-19 Liu, W.,Shi, X.,Gong, P. A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2018 46 10840 10854 5ZYU 30247721 The crystal structure of humanMGME1 with single strand DNA2 2018-05-28 2018-09-19 Yang, C.,Wu, R.,Liu, H.,Chen, Y.,Gao, Y.,Chen, X.,Li, Y.,Ma, J.,Li, J.,Gan, J. Structural insights into DNA degradation by human mitochondrial nuclease MGME1 Nucleic Acids Res. 2018 46 11075 11088 6AE4 30239956 Crystals structure of Classical swine fever virus NS5B (residues 1-694, Y471A mutant) 2018-08-03 2018-09-19 Liu, W.,Shi, X.,Gong, P. A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2018 46 10840 10854 6AE7 30239956 Crystals structure of Classical swine fever virus NS5B (residues 1-672, E472A mutant) 2018-08-03 2018-09-19 Liu, W.,Shi, X.,Gong, P. A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2018 46 10840 10854 5YEJ 29852200 Crystal structure of BioQ with its naturel double-stranded DNA operator 2017-09-17 2018-09-26 Yan, L.,Tang, Q.,Guan, Z.,Pei, K.,Zou, T.,He, J. Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway. Biochim Biophys Acta Gen Subj 2018 1862 1843 1851 5YEK 29852200 Crystal structure of BioQ 2017-09-17 2018-09-26 Yan, L.,Tang, Q.,Guan, Z.,Pei, K.,Zou, T.,He, J. Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway. Biochim Biophys Acta Gen Subj 2018 1862 1843 1851 5YFE 29603535 Enzymatic and structural characterization of the poly (ethylene terephthalate) hydrolase PETase from I. sakaiensis 2017-09-21 2018-09-26 Liu, B.,He, L.,Wang, L.,Li, T.,Li, C.,Liu, H.,Luo, Y.,Bao, R. Protein Crystallography and Site-Direct Mutagenesis Analysis of the Poly(ethylene terephthalate) Hydrolase PETase from Ideonella sakaiensis. Chembiochem 2018 0 0 0 5YGI 30270039 Crystal structure of human FPPS in complex with an inhibitor THZ93 2017-09-23 2018-09-26 Xia, Y.,Xie, Y.,Yu, Z.,Xiao, H.,Jiang, G.,Zhou, X.,Yang, Y.,Li, X.,Zhao, M.,Li, L.,Zheng, M.,Han, S.,Zong, Z.,Meng, X.,Deng, H.,Ye, H.,Fa, Y.,Wu, H.,Oldfield, E.,Hu, X.,Liu, W.,Shi, Y.,Zhang, Y. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell 2018 175 1059 0 5YL9 30198895 1.86 Angstrom crystal structure of human Coronavirus 229E fusion core 2017-10-17 2018-09-26 Yan, L.,Meng, B.,Xiang, J.,Wilson, I.A.,Yang, B. Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 angstrom resolution Acta Crystallogr D Struct Biol 2018 74 841 851 5YL9 30198895 1.86 Angstrom crystal structure of human Coronavirus 229E fusion core 2017-10-17 2018-09-26 Yan, L.,Meng, B.,Xiang, J.,Wilson, I.A.,Yang, B. Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 angstrom resolution Acta Crystallogr D Struct Biol 2018 74 841 851 5ZMM 30409991 Structure of the Type IV phosphorothioation-dependent restriction endonuclease ScoMcrA 2018-04-04 2018-09-26 Liu, G.,Fu, W.,Zhang, Z.,He, Y.,Yu, H.,Wang, Y.,Wang, X.,Zhao, Y.,Deng, Z.,Wu, G.,He, X. Structural basis for the recognition of sulfur in phosphorothioated DNA. Nat Commun 2018 9 4689 4689 5ZMN 30409991 Sulfur binding domain and SRA domain of ScoMcrA complexed with phosphorothioated DNA 2018-04-04 2018-09-26 Liu, G.,Fu, W.,Zhang, Z.,He, Y.,Yu, H.,Wang, Y.,Wang, X.,Zhao, Y.,Deng, Z.,Wu, G.,He, X. Structural basis for the recognition of sulfur in phosphorothioated DNA. Nat Commun 2018 9 4689 4689 5ZYP 30228257 Structure of the Yeast Ctr9/Paf1 complex 2018-05-28 2018-09-26 Xie, Y.,Zheng, M.,Chu, X.,Chen, Y.,Xu, H.,Wang, J.,Zhou, H.,Long, J. Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nat Commun 2018 9 3795 3795 6A9Y 30236986 The crystal structure of Mu homology domain of SGIP1 2018-07-16 2018-09-26 Zhang, Y.,Feng, Y.,Xin, Y.,Liu, X. SGIP1 dimerizes via intermolecular disulfide bond in mu HD domain during cellular endocytosis. Biochem. Biophys. Res. Commun. 2018 505 99 105 5YAA 30333187 Crystal structure of Marf1 NYN domain from Mus musculus 2017-08-31 2018-10-03 Yao, Q.,Cao, G.,Li, M.,Wu, B.,Zhang, X.,Zhang, T.,Guo, J.,Yin, H.,Shi, L.,Chen, J.,Yu, X.,Zheng, L.,Ma, J.,Su, Y.Q. Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Proc. Natl. Acad. Sci. U.S.A. 2018 115 11250 11255 5YC6 The crystal structure of uPA in complex with 4-Bromobenzylamirne at pH4.6 2017-09-06 2018-10-03 Jiang, L.G.,Zhang, X.,Zhou, Y.,Chen, Y.Y.,Luo, Z.P.,Li, J.Y.,Yuan, C.,Huang, M.D. Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases Rsc Adv 2018 8 28189 28197 5YC7 The crystal structure of uPA in complex with 4-Bromobenzylamirne at pH7.4 2017-09-06 2018-10-03 Jiang, L.G.,Zhang, X.,Zhou, Y.,Chen, Y.Y.,Luo, Z.P.,Li, J.Y.,Yuan, C.,Huang, M.D. Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases Rsc Adv 2018 8 28189 28197 5YZV 30154510 Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA 2017-12-15 2018-10-03 Shen, C.,Du, Y.,Qiao, F.,Kong, T.,Yuan, L.,Zhang, D.,Wu, X.,Li, D.,Wu, Y.D. Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA Sci Rep 2018 8 12965 12965 5ZUQ 30333166 P domain of GII.17-1978 2018-05-08 2018-10-03 Qian, Y.,Song, M.,Jiang, X.,Xia, M.,Meller, J.,Tan, M.,Chen, Y.,Li, X.,Rao, Z. Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths. J. Virol. 2019 93 0 0 5ZUS 30333166 P domain of GII.17-2014/15 2018-05-08 2018-10-03 Qian, Y.,Song, M.,Jiang, X.,Xia, M.,Meller, J.,Tan, M.,Chen, Y.,Li, X.,Rao, Z. Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths. J. Virol. 2019 93 0 0 5ZV5 30333166 P domain of GII.17-2014/15 complexed with A-trisaccharide 2018-05-09 2018-10-03 Qian, Y.,Song, M.,Jiang, X.,Xia, M.,Meller, J.,Tan, M.,Chen, Y.,Li, X.,Rao, Z. Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths. J. Virol. 2019 93 0 0 5ZV7 30333166 P domain of GII.17-2014/15 complexed with B-trisaccharide 2018-05-09 2018-10-03 Qian, Y.,Song, M.,Jiang, X.,Xia, M.,Meller, J.,Tan, M.,Chen, Y.,Li, X.,Rao, Z. Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths. J. Virol. 2019 93 0 0 6IF8 Aeromonas hydrophila MtaN-2 complexed with adenine 2018-09-18 2018-10-03 Chen, J.,Liu, W.,Wang, L.,Shang, F.,Lan, J.,Chen, Y.,Xu, Y. Aeromonas hydrophila MtaN-2 complexed with adenine To Be Published 0 0 0 0 5YJ7 33347927 Structural insight into the beta-GH1 glucosidase BGLN1 from oleaginous microalgae Nannochloropsis 2017-10-09 2018-10-10 Dong, S.,Liu, Y.J.,Zhou, H.,Xiao, Y.,Xu, J.,Cui, Q.,Wang, X.,Feng, Y. Structural insight into a GH1 beta-glucosidase from the oleaginous microalga, Nannochloropsis oceanica. Int.J.Biol.Macromol. 2021 170 196 206 5Z49 30084400 Crystal structure of the effector-binding domain of Synechococcus elongatus CmpR in complex with ribulose-1,5-bisphosphate 2018-01-10 2018-10-10 Mahounga, D.M.,Sun, H.,Jiang, Y.L. Crystal structure of the effector-binding domain of Synechococcus elongatus CmpR in complex with ribulose 1,5-bisphosphate. Acta Crystallogr F Struct Biol 2018 74 506 511 5ZCX 30096076 Structure of T20/N39 2018-02-21 2018-10-10 Zhang, X.,Ding, X.,Zhu, Y.,Chong, H.,Cui, S.,He, J.,Wang, X.,He, Y. Structural and functional characterization of HIV-1 cell fusion inhibitor T20. AIDS 2019 33 1 11 5ZTE 30279313 Crystal structure of PrxA C119S mutant from Arabidopsis thaliana 2018-05-03 2018-10-10 Yang, Y.,Cai, W.,Wang, J.,Pan, W.,Liu, L.,Wang, M.,Zhang, M. Crystal structure of Arabidopsis thaliana peroxiredoxin A C119S mutant. Acta Crystallogr F Struct Biol 2018 74 625 631 5YHW 31152619 Crystal structure of Pig SAMHD1 2017-09-30 2018-10-17 Kong, J.,Wang, M.M.,He, S.Y.,Peng, X.,Qin, X.H. Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation. Febs J. 2019 286 3844 3857 5YS1 30250139 Crystal structure of Multicopper Oxidase CueO G304K mutant 2017-11-12 2018-10-17 Wang, H.,Liu, X.,Zhao, J.,Yue, Q.,Yan, Y.,Gao, Z.,Dong, Y.,Zhang, Z.,Fan, Y.,Tian, J.,Wu, N.,Gong, Y. Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity Sci Rep 2018 8 14252 14252 5YKJ Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems 2017-10-14 2018-10-24 Li, C.C.,Yang, J.,Yang, M.J.,Liu, L.,Peng, C.T.,Li, T.,He, L.H.,Song, Y.J.,Zhu, Y.B.,Zhao, N.L.,Zhao, C.,Bao, R. Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems To be published 0 0 0 0 5YLB Crystal structure of Ofd2 from Schizosaccharomyces pombe at 1.80 A 2017-10-17 2018-10-24 Wang, J.,Gao, Y.X.,Guo, G.R.,Teng, M.K.,Niu, L.W. Crystal structure of Ofd2 from Schizosaccharomyces pombe at 1.80 A to be published 0 0 0 0 5YM3 30837155 CYP76AH1-4pi from salvia miltiorrhiza 2017-10-20 2018-10-24 Gu, M.,Wang, M.,Guo, J.,Shi, C.,Deng, J.,Huang, L.,Huang, L.,Chang, Z. Crystal structure of CYP76AH1 in 4-PI-bound state from Salvia miltiorrhiza. Biochem.Biophys.Res.Commun. 2019 511 813 819 5YM9 Crystal Structure of the Deamidase from Legionella pneumophila 2017-10-21 2018-10-24 Zhu, Z.L.,Zhu, M. Crystal Structure of the Deamidase from Legionella pneumophila To Be Published 0 0 0 0 5YMV 30341185 Crystal structure of 9-mer peptide from influenza virus in complex with BF2*1201 2017-10-22 2018-10-24 Xiao, J.,Xiang, W.,Zhang, Y.,Peng, W.,Zhao, M.,Niu, L.,Chai, Y.,Qi, J.,Wang, F.,Qi, P.,Pan, C.,Han, L.,Wang, M.,Kaufman, J.,Gao, G.F.,Liu, W.J. An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I. J Immunol. 2018 201 3084 3095 5YMW 30341185 Crystal structure of 8-mer peptide from Rous sarcoma virus in complex with BF2*1201 2017-10-22 2018-10-24 Xiao, J.,Xiang, W.,Zhang, Y.,Peng, W.,Zhao, M.,Niu, L.,Chai, Y.,Qi, J.,Wang, F.,Qi, P.,Pan, C.,Han, L.,Wang, M.,Kaufman, J.,Gao, G.F.,Liu, W.J. An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I. J Immunol. 2018 201 3084 3095 5ZNE 30355769 The crystal structure of immune receptor RGA5A_S of resistance protein Pia from rice (Oryza sativa) 2018-04-09 2018-10-24 Guo, L.,Cesari, S.,de Guillen, K.,Chalvon, V.,Mammri, L.,Ma, M.,Meusnier, I.,Bonnot, F.,Padilla, A.,Peng, Y.L.,Liu, J.,Kroj, T. Specific recognition of two MAX effectors by integrated HMA domains in plant immune receptors involves distinct binding surfaces Proc. Natl. Acad. Sci. U.S.A. 2018 115 11637 11642 5ZQ8 30388185 Crystal structure of spRlmCD with U747 stemloop RNA 2018-04-17 2018-10-24 Jiang, Y.,Yu, H.,Li, F.,Cheng, L.,Zhu, L.,Shi, Y.,Gong, Q. Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog. 2018 14 0 0 6BB3 Lactate Dehydrogenase in complex with inhibitor 3-((2-chlorophenyl)thio)-6-(6-((4-fluorophenyl)amino)pyridin-2-yl)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one 2017-10-16 2018-10-24 Wei, B.Q.,Labadie, S.S.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Gao, Z.,Ge, H.,Hitz, A.,Ho, Q.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A.,Purkey, H.E. Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published 0 0 0 0 6II4 30478290 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L4A-14 2018-10-03 2018-10-24 Huang, K.A.,Rijal, P.,Jiang, H.,Wang, B.,Schimanski, L.,Dong, T.,Liu, Y.M.,Chang, P.,Iqbal, M.,Wang, M.C.,Chen, Z.,Song, R.,Huang, C.C.,Yang, J.H.,Qi, J.,Lin, T.Y.,Li, A.,Powell, T.J.,Jan, J.T.,Ma, C.,Gao, G.F.,Shi, Y.,Townsend, A.R. Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans. Nat Microbiol 2019 4 306 315 6II8 30478290 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L4B-18 2018-10-03 2018-10-24 Huang, K.A.,Rijal, P.,Jiang, H.,Wang, B.,Schimanski, L.,Dong, T.,Liu, Y.M.,Chang, P.,Iqbal, M.,Wang, M.C.,Chen, Z.,Song, R.,Huang, C.C.,Yang, J.H.,Qi, J.,Lin, T.Y.,Li, A.,Powell, T.J.,Jan, J.T.,Ma, C.,Gao, G.F.,Shi, Y.,Townsend, A.R. Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans. Nat Microbiol 2019 4 306 315 6II9 30478290 Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a human neutralizing antibody L3A-44 2018-10-03 2018-10-24 Huang, K.A.,Rijal, P.,Jiang, H.,Wang, B.,Schimanski, L.,Dong, T.,Liu, Y.M.,Chang, P.,Iqbal, M.,Wang, M.C.,Chen, Z.,Song, R.,Huang, C.C.,Yang, J.H.,Qi, J.,Lin, T.Y.,Li, A.,Powell, T.J.,Jan, J.T.,Ma, C.,Gao, G.F.,Shi, Y.,Townsend, A.R. Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans. Nat Microbiol 2019 4 306 315 5Z08 30407575 The crystal structure of kinetochore subunits Cenp-H/I/K triple complex 2017-12-18 2018-10-31 Hu, L.,Huang, H.,Hei, M.,Yang, Y.,Li, S.,Liu, Y.,Dou, Z.,Wu, M.,Li, J.,Wang, G.Z.,Yao, X.,Liu, H.,He, X.,Tian, W. Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment. Nucleic Acids Res. 2019 47 468 479 5Z6Z 30322619 Crystal structure of human DUX4 homeodomains bound to DNA 2018-01-26 2018-10-31 Li, Y.,Wu, B.,Liu, H.,Gao, Y.,Yang, C.,Chen, X.,Zhang, J.,Chen, Y.,Gu, Y.,Li, J.,Ma, J.,Gan, J. Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun. 2018 505 1161 1167 6AIN 30217456 Crystal structure of p-nitrophenol 4-monooxygenase PnpA from Pseudomonas putida DLL-E4 2018-08-24 2018-10-31 Chen, Q.Z.,Huang, Y.,Duan, Y.J.,Li, Z.K.,Cui, Z.L.,Liu, W.D. Crystal structure of p-nitrophenol 4-monooxygenase PnpA from Pseudomonas putida DLL-E4: The key enzyme involved in p-nitrophenol degradation. Biochem. Biophys. Res. Commun. 2018 504 715 720 6AIO 30217456 Crystal structure of p-nitrophenol 4-monooxygenase PnpA from Pseudomonas putida DLL-E4 2018-08-24 2018-10-31 Chen, Q.Z.,Huang, Y.,Duan, Y.J.,Li, Z.K.,Cui, Z.L.,Liu, W.D. Crystal structure of p-nitrophenol 4-monooxygenase PnpA from Pseudomonas putida DLL-E4: The key enzyme involved in p-nitrophenol degradation. Biochem. Biophys. Res. Commun. 2018 504 715 720 5YOU Crystal structure of BRD4-BD1 bound with hjp64 2017-10-31 2018-11-07 Bing, X.,Jianping, H.,Yanlian, L.,Danyan, C. Crystal structure of BRD4-BD1 bound with hjp64 To Be Published 0 0 0 0 5YOV 29525435 Crystal structure of BRD4-BD1 bound with hjp126 2017-10-31 2018-11-07 Hu, J.,Wang, Y.,Li, Y.,Cao, D.,Xu, L.,Song, S.,Damaneh, M.S.,Li, J.,Chen, Y.,Wang, X.,Chen, L.,Shen, J.,Miao, Z.,Xiong, B. Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups. Eur.J.Med.Chem. 2018 150 156 175 5YYF 30374167 Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor ""PHQ-H3(Q5-K9)"" modified at K9 with 2-furancarboyl group 2017-12-09 2018-11-07 Li, X.,Li, X.M.,Jiang, Y.,Liu, Z.,Cui, Y.,Fung, K.Y.,van der Beelen, S.H.E.,Tian, G.,Wan, L.,Shi, X.,Allis, C.D.,Li, H.,Li, Y.,Li, X.D. Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking. Nat. Chem. Biol. 2018 14 1140 1149 5Z5N Crystal structure of ConA-R1M 2018-01-18 2018-11-07 Chen, G.S.,Gan, J.H.,Hu, R.T. Crystal structure of ConA-R1M (Only Mannose) To Be Published 0 0 0 0 5Z5P Crystal structure of ConA-R3M 2018-01-19 2018-11-07 Chen, G.S.,Gan, J.H.,Hu, R.T. Crystal structure of ConA-R3M To Be Published 0 0 0 0 5ZND 30336004 8-mer nanotube derived from 24-mer rHuHF nanocage 2018-04-09 2018-11-07 Wang, W.,Wang, L.,Chen, H.,Zang, J.,Zhao, X.,Zhao, G.,Wang, H. Selective Elimination of the Key Subunit Interfaces Facilitates Conversion of Native 24-mer Protein Nanocage into 8-mer Nanorings. J. Am. Chem. Soc. 2018 140 14078 14081 6A7W 30194678 Structure of a catalytic domain of the colistin resistance enzyme 2018-07-04 2018-11-07 Wang, X.,Lu, Q.,Qi, J.,Chai, Y.,Wang, Y.,Gao, G.F. Structural and functional insights into MCR-2 mediated colistin resistance. Sci China Life Sci 2018 61 1432 1436 6DF7 30289257 TAF1-BD2 in complex with Cpd27 (6-(but-3-en-1-yl)-4-(1-methyl-6-(morpholine-4-carbonyl)-1H-benzo[d]imidazol-4-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one) 2018-05-14 2018-11-14 Wang, S.,Tsui, V.,Crawford, T.D.,Audia, J.E.,Burdick, D.J.,Beresini, M.H.,Cote, A.,Cummings, R.,Duplessis, M.,Flynn, E.M.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Jiang, Y.,Joshi, S.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Taylor, A.M.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J. Med. Chem. 2018 61 9301 9315 5YOX HD domain-containing protein YGK1(YGL101W) 2017-10-31 2018-11-21 Yang, J.,Wang, F.,Zhou, K.,Gao, Z.,Liu, Q. HD domain-containing protein YGK1(YGL101W) To Be Published 0 0 0 0 5YTC 30407705 Large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with the unnatural base M-fC pair with dATP in the active site 2017-11-17 2018-11-21 Zeng, H.,Mondal, M.,Song, R.,Zhang, J.,Xia, B.,Liu, M.,Zhu, C.,He, B.,Gao, Y.Q.,Yi, C. Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl. 2019 58 130 133 5YTD 30407705 large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with the natural base pair 5fC:dGTP 2017-11-17 2018-11-21 Zeng, H.,Mondal, M.,Song, R.,Zhang, J.,Xia, B.,Liu, M.,Zhu, C.,He, B.,Gao, Y.Q.,Yi, C. Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl. 2019 58 130 133 5YTF 30407705 Structure of large fragment of DNA Polymerase I from Thermus aquaticus Host-Guest complex with the unnatural base M-fC pair with dA 2017-11-17 2018-11-21 Zeng, H.,Mondal, M.,Song, R.,Zhang, J.,Xia, B.,Liu, M.,Zhu, C.,He, B.,Gao, Y.Q.,Yi, C. Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl. 2019 58 130 133 5YTG 30407705 Structure of large fragment of DNA Polymerase I from Thermus aquaticus Host-Guest complex with the unnatural base I-fC pair with dA 2017-11-17 2018-11-21 Zeng, H.,Mondal, M.,Song, R.,Zhang, J.,Xia, B.,Liu, M.,Zhu, C.,He, B.,Gao, Y.Q.,Yi, C. Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl. 2019 58 130 133 5Z3N 30407705 Structure of large fragment of DNA Polymerase I from Thermus aquaticus Host-Guest complex with the unnatural base 5fC pair with dA 2018-01-08 2018-11-21 Zeng, H.,Mondal, M.,Song, R.,Zhang, J.,Xia, B.,Liu, M.,Zhu, C.,He, B.,Gao, Y.Q.,Yi, C. Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry. Angew. Chem. Int. Ed. Engl. 2019 58 130 133 5ZVA APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dC9) 2018-05-09 2018-11-21 Cheng, C.,Zhang, T.,Wang, C.,Lan, W.,Ding, J.,Cao, C. Crystal Structure of Cytidine Deaminase Human APOBEC3F Chimeric Catalytic Domain in Complex with DNA Chin.J.Chem. 2018 36 1241 1248 5ZVB APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dT9) 2018-05-09 2018-11-21 Cheng, C.,Zhang, T.,Wang, C.,Lan, W.,Ding, J.,Cao, C. Crystal Structure of Cytidine Deaminase Human APOBEC3F Chimeric Catalytic Domain in Complex with DNA Chin.J.Chem. 2018 36 1241 1248 6A20 30463954 Crystal Structure of auto-inhibited Kinesin-3 KIF13B 2018-06-08 2018-11-21 Ren, J.Q.,Wang, S.,Chen, H.,Wang, W.J.,Huo, L.,Feng, W. Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition. Proc. Natl. Acad. Sci. U.S.A. 2018 115 0 0 6AIB 30387775 Crystal structures of the N-terminal RecA-like domain 1 of Staphylococcus aureus DEAD-box Cold shock RNA helicase CshA 2018-08-22 2018-11-21 Chen, X.,Wang, C.,Zhang, X.,Tian, T.,Zang, J. Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP Acta Crystallogr F Struct Biol 2018 74 704 709 6IGC 30560935 Crystal structure of HPV58/33/52 chimeric L1 pentamer 2018-09-25 2018-11-21 Li, Z.,Song, S.,He, M.,Wang, D.,Shi, J.,Liu, X.,Li, Y.,Chi, X.,Wei, S.,Yang, Y.,Wang, Z.,Li, J.,Qian, H.,Yu, H.,Zheng, Q.,Yan, X.,Zhao, Q.,Zhang, J.,Gu, Y.,Li, S.,Xia, N. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun 2018 9 5360 5360 6IGD 30560935 Crystal structure of HPV58/33 chimeric L1 pentamer 2018-09-25 2018-11-21 Li, Z.,Song, S.,He, M.,Wang, D.,Shi, J.,Liu, X.,Li, Y.,Chi, X.,Wei, S.,Yang, Y.,Wang, Z.,Li, J.,Qian, H.,Yu, H.,Zheng, Q.,Yan, X.,Zhao, Q.,Zhang, J.,Gu, Y.,Li, S.,Xia, N. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun 2018 9 5360 5360 5XMY Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser 2017-05-16 2018-11-28 Zhao, S.,Zhang, B.,Li, H. Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser to be published 0 0 0 0 5YUQ 34358705 The high resolution structure of chitinase (RmChi1) from the thermophilic fungus Rhizomucor miehei (sp P1) 2017-11-23 2018-11-28 Jiang, Z.,Hu, S.,Ma, J.,Liu, Y.,Qiao, Z.,Yan, Q.,Gao, Y.,Yang, S. Crystal structure of a chitinase (RmChiA) from the thermophilic fungus Rhizomucor miehei with a real active site tunnel. Biochim Biophys Acta Proteins 2021 0 140709 140709 5Z2R 30341164 ThDP-Mn2+ complex of R395K variant of EcMenD soaked with 2-ketoglutarate for 5 min 2018-01-03 2018-11-28 Qin, M.M.,Song, H.G.,Dai, X.,Chen, Y.Z.,Guo, Z.H. Two active site arginines are critical determinants of substrate binding and catalysis in MenD: a thiamine-dependent enzyme in menaquinone biosynthesis. Biochem. J. 2018 475 3651 3667 5Z2U 30341164 ThDP-Mn2+ complex of R395A variant of EcMenD soaked with 2-ketoglutarate for 5 min 2018-01-04 2018-11-28 Qin, M.M.,Song, H.G.,Dai, X.,Chen, Y.Z.,Guo, Z.H. Two active site arginines are critical determinants of substrate binding and catalysis in MenD: a thiamine-dependent enzyme in menaquinone biosynthesis. Biochem. J. 2018 475 3651 3667 6IGF 30560935 Crystal structure of Human Papillomavirus type 52 pentamer 2018-09-25 2018-11-28 Li, Z.,Song, S.,He, M.,Wang, D.,Shi, J.,Liu, X.,Li, Y.,Chi, X.,Wei, S.,Yang, Y.,Wang, Z.,Li, J.,Qian, H.,Yu, H.,Zheng, Q.,Yan, X.,Zhao, Q.,Zhang, J.,Gu, Y.,Li, S.,Xia, N. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun 2018 9 5360 5360 6ISD 30632699 Crystal structure of Arabidopsis thaliana HPPD complexed with sulcotrione 2018-11-16 2018-11-28 Lin, H.Y.,Yang, J.F.,Wang, D.W.,Hao, G.F.,Dong, J.Q.,Wang, Y.X.,Yang, W.C.,Wu, J.W.,Zhan, C.G.,Yang, G.F. Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J. 2019 286 975 990 5YN6 Crystal structure of MERS-CoV nsp10/nsp16 complex bound to SAM 2017-10-24 2018-12-05 Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Che, Y.,Yang, Z.Z.,Guo, D.Y.,Fan, C.P. Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published 0 0 0 0 5YNM Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAM and m7GpppA 2017-10-24 2018-12-05 Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fan, C.P. Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published 0 0 0 0 5YNN Crystal structure of MERS-CoV nsp16/nsp10complex bound to sinefungin and m7GpppG 2017-10-24 2018-12-05 Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fan, C.P. Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published 0 0 0 0 5YTS 31160337 Crystal structure of YB1 cold-shock domain in complex with UCUUCU 2017-11-20 2018-12-05 Yang, X.J.,Zhu, H.,Mu, S.R.,Wei, W.J.,Yuan, X.,Wang, M.,Liu, Y.,Hui, J.,Huang, Y. Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem. 2019 294 10998 11010 5YTT 31160337 Crystal structure of YB1 cold-shock domain in complex with UCAUGU 2017-11-20 2018-12-05 Yang, X.J.,Zhu, H.,Mu, S.R.,Wei, W.J.,Yuan, X.,Wang, M.,Liu, Y.,Hui, J.,Huang, Y. Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem. 2019 294 10998 11010 5YTV 31160337 Crystal structure of YB1 cold-shock domain in complex with UCAUCU 2017-11-20 2018-12-05 Yang, X.J.,Zhu, H.,Mu, S.R.,Wei, W.J.,Yuan, X.,Wang, M.,Liu, Y.,Hui, J.,Huang, Y. Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem. 2019 294 10998 11010 5Z6Q 29710391 Crystal structure of AAA of Spastin 2018-01-25 2018-12-05 Fan, X.,Lin, Z.,Fan, G.,Lu, J.,Hou, Y.,Habai, G.,Sun, L.,Yu, P.,Shen, Y.,Wen, M.,Wang, C. The AAA protein spastin possesses two levels of basal ATPase activity FEBS Lett. 2018 592 1625 1633 6IGE 30560935 Crystal structure of Human Papillomavirus type 33 pentamer 2018-09-25 2018-12-05 Li, Z.,Song, S.,He, M.,Wang, D.,Shi, J.,Liu, X.,Li, Y.,Chi, X.,Wei, S.,Yang, Y.,Wang, Z.,Li, J.,Qian, H.,Yu, H.,Zheng, Q.,Yan, X.,Zhao, Q.,Zhang, J.,Gu, Y.,Li, S.,Xia, N. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun 2018 9 5360 5360 5YXN A T cell receptor in complex with HLA-A0201 restricted Hepatitis C virus NS3 peptide (KLVALGINAV) 2017-12-06 2018-12-12 Hui, F. Capturing HCV immune escape by targeting structural based mechanism To Be Published 0 0 0 0 5YXT Crystal structure of reducing end xylose-releasing exo-oligoxylanase 2017-12-07 2018-12-12 Jiang, Z.Q.,You, X.,Huang, P.,Ma, J.W. Structure of glycoside hydrolase family 8 xylanase at 1.88 Angstroms resolution To Be Published 0 0 0 0 5Z4H 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-01-11 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z4O 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-01-12 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9B 30429968 Bacterial GyrB ATPase domain in complex with (3,4-dichlorophenyl)hydrazine 2018-02-02 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9E 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-02-02 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9F 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-02-03 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9L 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-02-03 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9M 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-02-03 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9N 30429968 S.aureus GyrB ATPase domain in complex with 4,6-dichloro-2-(methylthio)pyrimidine 2018-02-03 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9P 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-02-04 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 5Z9Q 30429968 Bacterial GyrB ATPase domain in complex with a chemical fragment 2018-02-04 2018-12-12 Huang, X.,Guo, J.,Liu, Q.,Gu, Q.,Xu, J.,Zhou, H. Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes Medchemcomm 2018 9 1619 1629 6AFR 30529546 Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol 2018-08-08 2018-12-12 Xing, J.,Zhang, R.,Jiang, X.,Hu, T.,Wang, X.,Qiao, G.,Wang, J.,Yang, F.,Luo, X.,Chen, K.,Shen, J.,Luo, C.,Jiang, H.,Zheng, M. Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors Eur J Med Chem 2018 163 281 294 6AK1 30511672 Crystal structure of DmoA from Hyphomicrobium sulfonivorans 2018-08-28 2018-12-12 Cao, H.Y.,Wang, P.,Peng, M.,Shao, X.,Chen, X.L.,Li, C.Y. Crystal structure of the dimethylsulfide monooxygenase DmoA from Hyphomicrobium sulfonivorans. Acta Crystallogr.,Sect.F 2018 74 781 786 6F4V Crystal structure of cleaved Kallistatin complexed with heparin at 1.8 Angstrom resolution 2017-11-30 2018-12-12 Zhou, A.,Ma, L. Crystal structure of human Kallistatin To Be Published 0 0 0 0 5YZ4 29641590 Structure of the PIN domain endonuclease Utp24 2017-12-12 2018-12-19 An, W.,Du, Y.,Ye, K. Structural and functional analysis of Utp24, an endonuclease for processing 18S ribosomal RNA. Plos One 2018 13 0 0 5YZX Crystal structure of E.coli LysU T146D mutant 2017-12-16 2018-12-19 Zheng, L.,Ali, H.,Wang, J.,Guo, M.,Fang, P. A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli To Be Published 0 0 0 0 5ZA9 30130401 uPA-BB2-50F 2018-02-07 2018-12-19 Buckley, B.J.,Aboelela, A.,Minaei, E.,Jiang, L.X.,Xu, Z.,Ali, U.,Fildes, K.,Cheung, C.Y.,Cook, S.M.,Johnson, D.C.,Bachovchin, D.A.,Cook, G.M.,Apte, M.,Huang, M.,Ranson, M.,Kelso, M.J. 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J. Med. Chem. 2018 61 8299 8320 5ZA9 30130401 uPA-BB2-50F 2018-02-07 2018-12-19 Buckley, B.J.,Aboelela, A.,Minaei, E.,Jiang, L.X.,Xu, Z.,Ali, U.,Fildes, K.,Cheung, C.Y.,Cook, S.M.,Johnson, D.C.,Bachovchin, D.A.,Cook, G.M.,Apte, M.,Huang, M.,Ranson, M.,Kelso, M.J. 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J. Med. Chem. 2018 61 8299 8320 5ZA9 30130401 uPA-BB2-50F 2018-02-07 2018-12-19 Buckley, B.J.,Aboelela, A.,Minaei, E.,Jiang, L.X.,Xu, Z.,Ali, U.,Fildes, K.,Cheung, C.Y.,Cook, S.M.,Johnson, D.C.,Bachovchin, D.A.,Cook, G.M.,Apte, M.,Huang, M.,Ranson, M.,Kelso, M.J. 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J. Med. Chem. 2018 61 8299 8320 5ZKY Crystal structure of DFA-IIIase from Arthrobacter chlorophenolicus A6 without its lid 2018-03-26 2018-12-19 Yu, S.H.,Shen, H.,Cheng, Y.Y.,Zhu, Y.Y.,Li, X.,Mu, W.M. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue Acs Catalysis 2018 8 10683 10697 5ZL4 Crystal structure of DFA-IIIase from Arthrobacter chlorophenolicus A6 wihout its lid in complex with GF2 2018-03-26 2018-12-19 Yu, S.H.,Shen, H.,Cheng, Y.Y.,Zhu, Y.Y.,Li, X.,Mu, W.M. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue Acs Catalysis 2018 8 10683 10697 5ZL5 Crystal structure of DFA-IIIase mutant C387A from Arthrobacter chlorophenolicus A6 2018-03-26 2018-12-19 Yu, S.H.,Shen, H.,Cheng, Y.Y.,Zhu, Y.Y.,Li, X.,Mu, W.M. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue Acs Catalysis 2018 8 10683 10697 5ZLA Crystal structure of mutant C387A of DFA-IIIase from Arthrobacter chlorophenolicus A6 in complex with DFA-III 2018-03-27 2018-12-19 Yu, S.H.,Shen, H.,Cheng, Y.Y.,Zhu, Y.Y.,Li, X.,Mu, W.M. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue Acs Catalysis 2018 8 10683 10697 5Z0S 29562726 Crystal structure of FGFR1 kinase domain in complex with a novel inhibitor 2017-12-20 2018-12-26 Jiang, A.,Liu, Q.,Wang, R.,Wei, P.,Dai, Y.,Wang, X.,Xu, Y.,Ma, Y.,Ai, J.,Shen, J.,Ding, J.,Xiong, B. Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors Molecules 2018 23 0 0 5Z1C The crystal structure of uPA in complex with 4-Iodobenzylamine at pH7.4 2017-12-25 2018-12-26 Jiang, L.G.,Zhang, X.,Zhou, Y.,Chen, Y.Y.,Luo, Z.P.,Li, J.Y.,Yuan, C.,Huang, M.D. Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases Rsc Adv 2018 49 28189 28197 5ZBM 30143257 Structure of glycolate oxidase containing FMN from Nicotiana benthamiana 2018-02-12 2018-12-26 Liu, Y.,Wu, W.,Chen, Z. Structures of glycolate oxidase from Nicotiana benthamiana reveal a conserved pH sensor affecting the binding of FMN. Biochem.Biophys.Res.Commun. 2018 503 3050 3056 5ZI1 30506755 Crystal structure of Bacillus thuringiensis insecticidal crystal protein Cry7Ca1 (wild type) 2018-03-14 2018-12-26 Jing, X.,Yuan, Y.,Wu, Y.,Wu, D.,Gong, P.,Gao, M. Crystal structure of Bacillus thuringiensis Cry7Ca1 toxin active against Locusta migratoria manilensis. Protein Sci. 2019 28 609 619 6AJH 30682372 Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with AU1235 2018-08-27 2018-12-26 Zhang, B.,Li, J.,Yang, X.,Wu, L.,Zhang, J.,Yang, Y.,Zhao, Y.,Zhang, L.,Yang, X.,Yang, X.,Cheng, X.,Liu, Z.,Jiang, B.,Jiang, H.,Guddat, L.W.,Yang, H.,Rao, Z. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell 2019 176 636 0 6ISA 30591568 mCD226 2018-11-16 2018-12-26 Wang, H.,Qi, J.,Zhang, S.,Li, Y.,Tan, S.,Gao, G.F. Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5. Proc. Natl. Acad. Sci. U.S.A. 2019 116 988 996 6ISB 30591568 crystal structure of human CD226 2018-11-16 2018-12-26 Wang, H.,Qi, J.,Zhang, S.,Li, Y.,Tan, S.,Gao, G.F. Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5. Proc. Natl. Acad. Sci. U.S.A. 2019 116 988 996 6ISC 30591568 complex structure of mCD226-ecto and hCD155-D1 2018-11-16 2018-12-26 Wang, H.,Qi, J.,Zhang, S.,Li, Y.,Tan, S.,Gao, G.F. Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5. Proc. Natl. Acad. Sci. U.S.A. 2019 116 988 996 6ITS 31177588 The citrate-bound trimer of chemoreceptor MCP2201 ligand binding domain 2018-11-26 2018-12-26 Hong, Y.,Huang, Z.,Guo, L.,Ni, B.,Jiang, C.Y.,Li, X.J.,Hou, Y.J.,Yang, W.S.,Wang, D.C.,Zhulin, I.B.,Liu, S.J.,Li, D.F. The ligand-binding domain of a chemoreceptor from Comamonas testosteroni has a previously unknown homotrimeric structure. Mol.Microbiol. 2019 112 906 917 5YZJ Crystal structure of human Archease mutant D51A 2017-12-15 2019-01-02 Duan, S.Y.,Li, J.X. Structural and mechanistic insights into hArchease mutant D51A To Be Published 0 0 0 0 5Z7A 30459273 Crystal structure of NDP52 SKICH region 2018-01-27 2019-01-02 Fu, T.,Liu, J.,Wang, Y.,Xie, X.,Hu, S.,Pan, L. Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A. 2018 115 0 0 5Z7C 30365951 crystal structure of cyclic GMP-AMP specifc phosphodiesterases in V.cholerae (V-cGAP3) 2018-01-28 2019-01-02 Deng, M.J.,Tao, J.,E, C.,Ye, Z.Y.,Jiang, Z.,Yu, J.,Su, X.D. Novel Mechanism for Cyclic Dinucleotide Degradation Revealed by Structural Studies of Vibrio Phosphodiesterase V-cGAP3. J. Mol. Biol. 2018 430 5080 5093 5Z7G 30459273 Crystal structure of TAX1BP1 SKICH region in complex with NAP1 2018-01-28 2019-01-02 Fu, T.,Liu, J.,Wang, Y.,Xie, X.,Hu, S.,Pan, L. Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A. 2018 115 0 0 5Z7L 30459273 Crystal structure of NDP52 SKICH region in complex with NAP1 2018-01-29 2019-01-02 Fu, T.,Liu, J.,Wang, Y.,Xie, X.,Hu, S.,Pan, L. Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A. 2018 115 0 0 6AE9 30453087 X-ray structure of the photosystem II phosphatase PBCP 2018-08-03 2019-01-02 Liu, X.,Chai, J.,Ou, X.,Li, M.,Liu, Z. Structural Insights into Substrate Selectivity, Catalytic Mechanism, and Redox Regulation of Rice Photosystem II Core Phosphatase. Mol Plant 2019 12 86 98 6IRB 30526850 C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine 2018-11-12 2019-01-02 Ye, F.,Huang, Y.,Li, J.,Ma, Y.,Xie, C.,Liu, Z.,Deng, X.,Wan, J.,Xue, T.,Liu, W.,Zhang, M. An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife 2018 7 0 0 6IRC 30526850 C-terminal domain of Drosophila phospholipase b NORPA, methylated 2018-11-12 2019-01-02 Ye, F.,Huang, Y.,Li, J.,Ma, Y.,Xie, C.,Liu, Z.,Deng, X.,Wan, J.,Xue, T.,Liu, W.,Zhang, M. An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife 2018 7 0 0 6IWE Crystal structure of fructosyl peptide oxidase thermally stable mutant 2018-12-05 2019-01-02 Fuqiang, M.,Guangyu, Y. crystal structure of fructosyl peptide oxidase thermally stable mutant To Be Published 0 0 0 0 5YWG 30632699 Crystal structure of Arabidopsis thaliana HPPD complexed with Mesotrione 2017-11-29 2019-01-16 Lin, H.Y.,Yang, J.F.,Wang, D.W.,Hao, G.F.,Dong, J.Q.,Wang, Y.X.,Yang, W.C.,Wu, J.W.,Zhan, C.G.,Yang, G.F. Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J. 2019 286 975 990 5YWH Crystal structure of Arabidopsis thaliana HPPD complexed with Y13508 2017-11-29 2019-01-16 Yang, W.C.,Lin, H.Y. Crystal structure of Arabidopsis thaliana HPPD complexed with Y13508 To be published 0 0 0 0 5YWI Crystal structure of Arabidopsis thaliana HPPD Truncated mutant complexed with NTBC 2017-11-29 2019-01-16 Yang, W.C.,Chen, J.N. Crystal structure of Arabidopsis thaliana HPPD Truncated mutant complexed with NTBC To be published 0 0 0 0 5YWK 33395281 Crystal structure of Arabidopsis thaliana HPPD complexed with Benquitrione-Methyl 2017-11-29 2019-01-16 Qu, R.Y.,Nan, J.X.,Yan, Y.C.,Chen, Q.,Ndikuryayo, F.,Wei, X.F.,Yang, W.C.,Lin, H.Y.,Yang, G.F. Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide. J.Agric.Food Chem. 2021 69 459 473 5Z3W Malate dehydrogenase binds silver at C113 2018-01-09 2019-01-16 Wang, H.,Yang, X.,Wang, M.,Hu, M.,Xu, X.,Yan, A.,Hao, Q.,Li, H.,Sun, H. Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm Chem Sci 2020 0 0 0 5ZI0 Ketoreductase LbCR mutant - M8 2018-03-14 2019-01-16 Gong, X.M.,Zhen, Q.,Li, F.L.,Zeng, B.B.,Zheng, G.W.,Xu, J.H. Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor Acs Catalysis 2019 9 147 153 6A2H 30499242 Architectural roles of Cren7 in folding crenarchaeal chromatin filament 2018-06-11 2019-01-16 Zhang, Z.,Zhao, M.,Chen, Y.,Wang, L.,Liu, Q.,Dong, Y.,Gong, Y.,Huang, L. Architectural roles of Cren7 in folding crenarchaeal chromatin filament. Mol. Microbiol. 2019 111 556 569 6A2I 30499242 Architectural roles of Cren7 in folding crenarchaeal chromatin filament 2018-06-11 2019-01-16 Zhang, Z.,Zhao, M.,Chen, Y.,Wang, L.,Liu, Q.,Dong, Y.,Gong, Y.,Huang, L. Architectural roles of Cren7 in folding crenarchaeal chromatin filament. Mol. Microbiol. 2019 111 556 569 6AKK 30622739 Crystal structure of the second Coiled-coil domain of SIKE1 2018-09-02 2019-01-16 Tang, Y.,Chen, M.,Zhou, L.,Ma, J.,Li, Y.,Zhang, H.,Shi, Z.,Xu, Q.,Zhang, X.,Gao, Z.,Zhao, Y.,Cheng, Y.,Jiao, S.,Zhou, Z. Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov 2019 5 3 3 6C6N 30626872 Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and Cmpd-4"" 2018-01-19 2019-01-16 Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A. Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun 2019 10 97 97 6C6P 30626872 Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and NB-598 2018-01-19 2019-01-16 Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A. Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun 2019 10 97 97 6C6R 30626872 Human Squalene Epoxidase (SQLE, Squalene Monooxygenase) structure with FAD 2018-01-19 2019-01-16 Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A. Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun 2019 10 97 97 6C6R 30626872 Human Squalene Epoxidase (SQLE, Squalene Monooxygenase) structure with FAD 2018-01-19 2019-01-16 Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A. Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun 2019 10 97 97 6IDE 30610119 Crystal structure of the Vibrio cholera VqmA-Ligand-DNA complex provides molecular mechanisms for drug design 2018-09-09 2019-01-16 Wu, H.,Li, M.,Guo, H.,Zhou, H.,Li, B.,Xu, Q.,Xu, C.,Yu, F.,He, J. Crystal structure of theVibrio choleraeVqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design. J. Biol. Chem. 2019 294 2580 2592 6IE4 Crystal structure of ADCP1 tandem Agenet domain 1-2 in complex with H3K9me1 2018-09-13 2019-01-16 Zhao, S.,Zhang, B.,Li, H. ADCP1-tandem Agenet domain 1-2 in complex wit h H3K9me2 Cell Res. 2019 29 54 66 6IE5 Crystal structure of ADCP1 tandem Agenet domain 3-4 2018-09-13 2019-01-16 Zhao, S.,Zhang, B.,Li, H. ADCP1-tandem Agenet domain 1-2 in complex wit h H3K9me2 Cell Res. 2019 29 54 66 6IE6 Crystal structure of ADCP1 tandem Agenet domain 3-4 in complex with H3K9me2 2018-09-13 2019-01-16 Zhao, S.,Zhang, B.,Li, H. ADCP1-tandem Agenet domain 1-2 in complex wit h H3K9me2 Cell Res. 2019 29 54 66 6IE7 Crystal structure of ADCP1 tandem Agenet domain 1-2 in complex with H3K9me2 2018-09-13 2019-01-16 Zhao, S.,Zhang, B.,Li, H. ADCP1-tandem Agenet domain 1-2 in complex wit h H3K9me2 Cell Res. 2019 29 54 66 6IUT 30737282 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01 2018-11-30 2019-01-16 Wang, P.,Zuo, Y.,Sun, J.,Zuo, T.,Zhang, S.,Guo, S.,Shi, X.,Liang, M.,Zhou, P.,Zhang, L.,Wang, X. Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J. Biol. Chem. 2019 294 4290 4303 6IUV 30737282 Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 3C11 2018-11-30 2019-01-16 Wang, P.,Zuo, Y.,Sun, J.,Zuo, T.,Zhang, S.,Guo, S.,Shi, X.,Liang, M.,Zhou, P.,Zhang, L.,Wang, X. Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J. Biol. Chem. 2019 294 4290 4303 5Z3K 31921083 Crystal structure of glucosidase from Croceicoccus marinus at 1.8 Angstrom resolution 2018-01-08 2019-01-23 Shen, Y.,Li, Z.,Huo, Y.Y.,Bao, L.,Gao, B.,Xiao, P.,Hu, X.,Xu, X.W.,Li, J. Structural and Functional Insights Into CmGH1, a Novel GH39 Family beta-Glucosidase From Deep-Sea Bacterium. Front Microbiol 2019 10 2922 2922 5ZR4 29730293 Manganese-dependent transcriptional repressor 2018-04-23 2019-01-23 Cong, X.Y.,Yuan, Z.L.,Wang, Z.,Wei, B.,Xu, S.J.,Wang, J.B. Crystal structures of manganese-dependent transcriptional repressor MntR (Rv2788) from Mycobacterium tuberculosis in apo and manganese bound forms. Biochem. Biophys. Res. Commun. 2018 501 423 427 6IM4 30421358 Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages 2018-10-22 2019-01-23 Zhen, X.,Zhou, H.,Ding, W.,Zhou, B.,Xu, X.,Perculija, V.,Chen, C.J.,Chang, M.X.,Choudhary, M.I.,Ouyang, S. Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages. Protein Cell 2019 10 131 136 6IPX 30421358 Crystal structure of the apo form transcription factor 2018-11-05 2019-01-23 Zhen, X.,Zhou, H.,Ding, W.,Zhou, B.,Xu, X.,Perculija, V.,Chen, C.J.,Chang, M.X.,Choudhary, M.I.,Ouyang, S. Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages. Protein Cell 2019 10 131 136 6IRD 30526850 Complex structure of INADL PDZ89 and PLCb4 C-terminal CC-PBM 2018-11-12 2019-01-23 Ye, F.,Huang, Y.,Li, J.,Ma, Y.,Xie, C.,Liu, Z.,Deng, X.,Wan, J.,Xue, T.,Liu, W.,Zhang, M. An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife 2018 7 0 0 6IRE 30526850 Complex structure of INAD PDZ45 and NORPA CC-PBM 2018-11-12 2019-01-23 Ye, F.,Huang, Y.,Li, J.,Ma, Y.,Xie, C.,Liu, Z.,Deng, X.,Wan, J.,Xue, T.,Liu, W.,Zhang, M. An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife 2018 7 0 0 6ISO 25369635 Human SIRT3 Recognizing H3K4cr 2018-11-17 2019-01-23 Bao, X.,Wang, Y.,Li, X.,Li, X.M.,Liu, Z.,Yang, T.,Wong, C.F.,Zhang, J.,Hao, Q.,Li, X.D. Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. Elife 2014 3 0 0 6N1S 30624926 Toxoplasma gondii TS-DHFR in complex with selective inhibitor 29 2018-11-11 2019-01-23 Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J. Med. Chem. 2019 62 1562 1576 6N1T 30624926 Toxoplasma gondii TS-DHFR in complex with selective inhibitor 3 2018-11-11 2019-01-23 Hopper, A.T.,Brockman, A.,Wise, A.,Gould, J.,Barks, J.,Radke, J.B.,Sibley, L.D.,Zou, Y.,Thomas, S. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J. Med. Chem. 2019 62 1562 1576 5Y2L Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the 1968 H3N2 pandemic (H3-AC/68) hemagglutinin 2017-07-26 2019-01-30 Xiao, H.,Qi, J.,Gao, F.G. An H3-clade neutralizing antibody screened from an H7N9 patient that binds group 2 influenza A hemagglutinins To Be Published 0 0 0 0 5YR2 Structure of cpGFP66BPA 2017-11-08 2019-01-30 Wang, L.,Kang, F. Structure of cpGFP66BPA To Be Published 0 0 0 0 5YR3 Structure of sfYFP66BPA 2017-11-08 2019-01-30 Kang, F.,Wang, L. sfYFP66BPA To Be Published 0 0 0 0 5Z6R SPASTIN AAA WITH ATP 2018-01-25 2019-01-30 Lin, Z.,Wang, C.,Shen, Y. The Aaa Family Protein Spastin Severs A Microtubule To Be Published 0 0 0 0 5ZO2 30674679 Crystal structure of mouse nectin-like molecule 4 (mNecl-4) full ectodomain in complex with mouse nectin-like molecule 1 (mNecl-1) Ig1 domain, 3.3A 2018-04-12 2019-01-30 Liu, X.,An, T.,Li, D.,Fan, Z.,Xiang, P.,Li, C.,Ju, W.,Li, J.,Hu, G.,Qin, B.,Yin, B.,Wojdyla, J.A.,Wang, M.,Yuan, J.,Qiang, B.,Shu, P.,Cui, S.,Peng, X. Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules. Proc. Natl. Acad. Sci. U.S.A. 2019 116 2068 2077 5ZOD 30295841 Crystal Structure of hFen1 in apo form 2018-04-13 2019-01-30 Xu, H.,Shi, R.,Han, W.,Cheng, J.,Xu, X.,Cheng, K.,Wang, L.,Tian, B.,Zheng, L.,Shen, B.,Hua, Y.,Zhao, Y. Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res. 2018 46 11315 11325 5ZOE 30295841 Crystal Structure of D181A hFen1 in complex with DNA 2018-04-13 2019-01-30 Xu, H.,Shi, R.,Han, W.,Cheng, J.,Xu, X.,Cheng, K.,Wang, L.,Tian, B.,Zheng, L.,Shen, B.,Hua, Y.,Zhao, Y. Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res. 2018 46 11315 11325 5ZOF 30295841 Crystal Structure of D181A/R192F hFen1 in complex with DNA 2018-04-13 2019-01-30 Xu, H.,Shi, R.,Han, W.,Cheng, J.,Xu, X.,Cheng, K.,Wang, L.,Tian, B.,Zheng, L.,Shen, B.,Hua, Y.,Zhao, Y. Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res. 2018 46 11315 11325 5ZOG 30295841 Crystal Structure of R192F hFen1 in complex with DNA 2018-04-13 2019-01-30 Xu, H.,Shi, R.,Han, W.,Cheng, J.,Xu, X.,Cheng, K.,Wang, L.,Tian, B.,Zheng, L.,Shen, B.,Hua, Y.,Zhao, Y. Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res. 2018 46 11315 11325 6IH0 Aquifex aeolicus LpxC complex with ACHN-975 2018-09-27 2019-01-30 Fan, S.,Li, D.,Yan, M.,Feng, X.,Lv, G.,Wu, G.,Jin, Y.,Wang, Y.,Yang, Z. The Complex Structure of Protein AaLpxC from Aquifex aeolicus with ACHN-975 Molecule Suggests an Inhibitory Mechanism at Atomic-Level against Gram-Negative Bacteria Molecules 2021 26 0 0 5Z87 Structural of a novel b-glucosidase EmGH1 at 2.3 angstrom from Erythrobacter marinus 2018-01-31 2019-02-06 Li, L.,Zhao, Y.,Hu, X.J.,Li, J.X. Structural and biochemical analysis of a novel b-glucosidase EmGH1 from Erythrobacter marinus To Be Published 0 0 0 0 5Z93 Crystal Structure of SIRT3 in complex with H3K9bhb peptide 2018-02-02 2019-02-06 Zhang, X.,Li, H. Crystal Structure of SIRT3 in complex with H3K9bhb peptide To Be Published 0 0 0 0 5Z94 Crystal Structure of SIRT3 in complex with H3K4bhb peptide 2018-02-02 2019-02-06 Zhang, X.,Li, H. Crystal Structure of SIRT3 in complex with H3K4bhb peptide To Be Published 0 0 0 0 5Z9R 32250733 NMNAT as a specific chaperone antagonizing pathological condensation of phosphorylated tau 2018-02-05 2019-02-06 Ma, X.,Zhu, Y.,Lu, J.,Xie, J.,Li, C.,Shin, W.S.,Qiang, J.,Liu, J.,Dou, S.,Xiao, Y.,Wang, C.,Jia, C.,Long, H.,Yang, J.,Fang, Y.,Jiang, L.,Zhang, Y.,Zhang, S.,Zhai, R.G.,Liu, C.,Li, D. Nicotinamide mononucleotide adenylyltransferase uses its NAD+substrate-binding site to chaperone phosphorylated Tau. Elife 2020 9 0 0 5ZA3 Structure of a C-terminal S. mutans response regulator VicR domain 2018-02-06 2019-02-06 Cai, Y.F.,Hu, X.J.,San, J.Y.,Han, A.D. Structure of a C-terminal S. mutans response regulator VicR domain To Be Published 0 0 0 0 5ZMP The structure of a lysine deacylase 2018-04-05 2019-02-06 Ge, F. The structure of a lysine deacylase To Be Published 0 0 0 0 6AKP 30722065 Crystal Structural of FOXC2 DNA binding domain bound to PC promoter 2018-09-03 2019-02-06 Chen, X.,Wei, H.,Li, J.,Liang, X.,Dai, S.,Jiang, L.,Guo, M.,Qu, L.,Chen, Z.,Chen, L.,Chen, Y. Structural basis for DNA recognition by FOXC2. Nucleic Acids Res. 2019 47 3752 3764 6IV7 The crystal structure of a SAM-dependent enzyme from aspergillus flavus 2018-12-02 2019-02-06 Zhou, Y.Z.,Peng, T.,Liao, L.J.,Zhao, Y.C.,Liu, X.K.,Guo, Y.,Zeng, Z.X. The crystal structure of A SAM-Dependent enzyme from Aspergillus flavus To Be Published 0 0 0 0 6J63 30632699 Crystal structure of Arabidopsis thaliana HPPD complexed with NTBC 2019-01-13 2019-02-06 Lin, H.Y.,Yang, J.F.,Wang, D.W.,Hao, G.F.,Dong, J.Q.,Wang, Y.X.,Yang, W.C.,Wu, J.W.,Zhan, C.G.,Yang, G.F. Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J. 2019 286 975 990 6J8L 30703565 Phytophthora sojae effector PsAvh240 inhibits a host aspartic protease secretion to promote infection 2019-01-19 2019-02-06 Guo, B.,Wang, H.,Yang, B.,Jiang, W.,Jing, M.,Li, H.,Xia, Y.,Xu, Y.,Hu, Q.,Wang, F.,Yu, F.,Wang, Y.,Ye, W.,Dong, S.,Xing, W.,Wang, Y. Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection. Mol Plant 2019 12 552 564 5Y2M Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the H4N6 duck isolate (H4-CZ/56) hemagglutinin 2017-07-26 2019-02-13 Xiao, H.,Qi, J.,Gao, F.G. An H3-clade neutralizing antibody screened from an H7N9 patient that binds group 2 influenza A hemagglutinins To Be Published 0 0 0 0 5ZAN Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor 2018-02-07 2019-02-13 Long, L.,Peng, W.,Pan, Y.,Cheng, B.,Tu, Z.,Long, Z.,Zhou, H.,Liu, Q.,Lu, G. Optimization of Novel Quinazolines as Potent and Orally Bioavailable Aurora Kinase Inhibitors To Be Published 0 0 0 0 5ZBE 30742895 Crystal structure of AerE from Microcystis aeruginosa 2018-02-11 2019-02-13 Qiu, X.,Zhu, W.,Wang, W.,Jin, H.,Zhu, P.,Zhuang, R.,Yan, X. Structural and functional insights into the role of a cupin superfamily isomerase in the biosynthesis of Choi moiety of aeruginosin. J. Struct. Biol. 2019 205 44 52 5ZBF 30742895 Crystal structure of 4-hydroxyphenylpyruvic acid bound AerE from Microcystis aeruginosa 2018-02-11 2019-02-13 Qiu, X.,Zhu, W.,Wang, W.,Jin, H.,Zhu, P.,Zhuang, R.,Yan, X. Structural and functional insights into the role of a cupin superfamily isomerase in the biosynthesis of Choi moiety of aeruginosin. J. Struct. Biol. 2019 205 44 52 6A5Q 30653408 Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif 2018-06-25 2019-02-13 Xu, Y.,Ren, J.,He, X.,Chen, H.,Wei, T.,Feng, W. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy 2019 15 1017 1030 6A5S 30653408 Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif 2018-06-25 2019-02-13 Xu, Y.,Ren, J.,He, X.,Chen, H.,Wei, T.,Feng, W. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy 2019 15 1017 1030 5Y49 A moderator XD22 binding to bile acid receptor 2017-08-02 2019-02-20 Lu, Y.,Li, Y. A moderator XD22 binding to bile acid receptor To Be Published 0 0 0 0 5Z16 A novel dimeric isocitrate dehydrogenase from Acinetobacter baumannii 2017-12-25 2019-02-20 Wang, P.,Zhu, G.P.,Song, P.,Huang, S.P. A novel dimeric isocitrate dehydrogenase from Acinetobacter baumannii To Be Published 0 0 0 0 5ZBZ 31402318 Crystal structure of the DEAD domain of Human eIF4A with sanguinarine 2018-02-14 2019-02-20 Jiang, C.,Tang, Y.,Ding, L.,Tan, R.,Li, X.,Lu, J.,Jiang, J.,Cui, Z.,Tang, Z.,Li, W.,Cao, Z.,Schneider-Poetsch, T.,Jiang, W.,Luo, C.,Ding, Y.,Liu, J.,Dang, Y. Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling. Cell Chem Biol 2019 26 1417 0 5ZNS 30755482 Insect chitin deacetylase 2018-04-10 2019-02-20 Liu, L.,Zhou, Y.,Qu, M.,Qiu, Y.,Guo, X.,Zhang, Y.,Liu, T.,Yang, J.,Yang, Q. Structural and biochemical insights into the catalytic mechanisms of two insect chitin deacetylases of the carbohydrate esterase 4 family. J. Biol. Chem. 2019 294 5774 5783 5ZNT 30755482 Insect chitin deacetylase 2018-04-10 2019-02-20 Liu, L.,Zhou, Y.,Qu, M.,Qiu, Y.,Guo, X.,Zhang, Y.,Liu, T.,Yang, J.,Yang, Q. Structural and biochemical insights into the catalytic mechanisms of two insect chitin deacetylases of the carbohydrate esterase 4 family. J. Biol. Chem. 2019 294 5774 5783 5XRC A Trimodular GH5_4 Subfamily Endoglucanase Structure with Large Unit Cell 2017-06-08 2019-02-27 Zhang, H.D.,Yao, C.X. Molecular Characterization of a Trimodular GH5_4 Subfamily Endoglucanase Structure with Large Unit Cell To Be Published 0 0 0 0 5XZ6 29940104 Crystal Structure of Phosphofructokinase from Staphylococcus aureus in complex with adenylylimidodiphosphate, the ATP analogue 2017-07-11 2019-02-27 Tian, T.,Wang, C.L.,Wu, M.H.,Zhang, X.,Zang, J.Y. Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion. Biochemistry 2018 57 4252 4262 5XZ8 29940104 Crystal Structure of Phosphofructokinase from Staphylococcus aureus in complex with adenylylimidodiphosphate (the ATP analog) and fructose-6-phosphate 2017-07-11 2019-02-27 Tian, T.,Wang, C.L.,Wu, M.H.,Zhang, X.,Zang, J.Y. Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion. Biochemistry 2018 57 4252 4262 5YQH The crystal structure of CYP199A4 binding with 4-n-Propyl benzoic acid 2017-11-06 2019-02-27 Coleman, T.,Zhang, T.,Qiao, R.,Zhou, W.,Beii, S. The crystal structure of CYP199A4 binding with 4-n-Propyl benzoic acid To Be Published 0 0 0 0 5ZM5 30783101 Crystal structure of human ORP1-ORD in complex with cholesterol at 2.6 A resolution 2018-04-01 2019-02-27 Dong, J.,Du, X.,Wang, H.,Wang, J.,Lu, C.,Chen, X.,Zhu, Z.,Luo, Z.,Yu, L.,Brown, A.J.,Yang, H.,Wu, J.W. Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun 2019 10 829 829 5ZM6 30783101 Crystal structure of ORP1-ORD in complex with PI(4,5)P2 2018-04-01 2019-02-27 Dong, J.,Du, X.,Wang, H.,Wang, J.,Lu, C.,Chen, X.,Zhu, Z.,Luo, Z.,Yu, L.,Brown, A.J.,Yang, H.,Wu, J.W. Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun 2019 10 829 829 5ZM7 30783101 Crystal structure of ORP1-ORD in complex with cholesterol at 3.4 A resolution 2018-04-01 2019-02-27 Dong, J.,Du, X.,Wang, H.,Wang, J.,Lu, C.,Chen, X.,Zhu, Z.,Luo, Z.,Yu, L.,Brown, A.J.,Yang, H.,Wu, J.W. Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun 2019 10 829 829 6ICT 30785395 Structure of SETD3 bound to SAH and methylated actin 2018-09-07 2019-02-27 Guo, Q.,Liao, S.,Kwiatkowski, S.,Tomaka, W.,Yu, H.,Wu, G.,Tu, X.,Min, J.,Drozak, J.,Xu, C. Structural insights into SETD3-mediated histidine methylation on beta-actin. Elife 2019 8 0 0 6ILH 30733335 Crystal Structure of human lysyl-tRNA synthetase L350H mutant 2018-10-18 2019-02-27 Hei, Z.,Wu, S.,Liu, Z.,Wang, J.,Fang, P. Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. J. Biol. Chem. 2019 294 4775 4783 6IV5 31318636 Crystal structure of arabidopsis N6-mAMP deaminase MAPDA 2018-12-02 2019-02-27 Wu, B.,Zhang, D.,Nie, H.,Shen, S.,Li, Y.,Li, S. Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing. Rna Biol. 2019 16 1504 1512 6J71 31205018 HuA21-scFv in complex with the extracellular domain(ECD) of HER2 2019-01-16 2019-02-27 Wang, Z.,Cheng, L.,Guo, G.,Cheng, B.,Hu, S.,Zhang, H.,Zhu, Z.,Niu, L. Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells. Acta Crystallogr D Struct Biol 2019 75 554 563 5YW4 31866427 Structure-Guided Engineering of Reductase: Efficient Attenuating Substrate Inhibition in Asymmetric Catalysis 2017-11-28 2019-03-06 Shang, Y.P.,Chen, Q.,Li, A.T.,Quan, S.,Xu, J.H.,Yu, H.L. Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol. 2020 308 141 147 5YWL 31866427 SsCR_L211H 2017-11-29 2019-03-06 Shang, Y.P.,Chen, Q.,Li, A.T.,Quan, S.,Xu, J.H.,Yu, H.L. Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol. 2020 308 141 147 5YWN 31866427 SsCR_L211H-NADP+ 2017-11-29 2019-03-06 Shang, Y.P.,Chen, Q.,Li, A.T.,Quan, S.,Xu, J.H.,Yu, H.L. Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering. J.Biotechnol. 2020 308 141 147 5ZF3 Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose 2018-03-02 2019-03-06 Zhang, X.,Wan, Q.,Li, Z. Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose To be published 0 0 0 0 5ZPW 30109011 Generation of a long-acting fusion inhibitor against HIV-1 2018-04-16 2019-03-06 Guo, Y.,Zhou, P.P.,Zhang, S.Y.,Fan, X.W.,Dou, Y.W.,Shi, X.L. Generation of a long-acting fusion inhibitor against HIV-1. Medchemcomm 2018 9 1226 1231 6A85 30285239 Crystal structure of a novel DNA quadruplex 2018-07-06 2019-03-06 Liu, H.H.,Wang, R.,Yu, X.,Shen, F.S.,Lan, W.X.,Haruehanroengra, P.,Yao, Q.Q.,Zhang, J.,Chen, Y.Q.,Li, S.H.,Wu, B.X.,Zheng, L.N.,Ma, J.B.,Lin, J.Z.,Cao, C.Y.,Li, J.X.,Sheng, J.,Gan, J.H. High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads. Nucleic Acids Res. 2018 46 11627 11638 6IXP 30804213 Structure of Myo2-GTD in complex with Mmr1 2018-12-11 2019-03-06 Tang, K.,Li, Y.,Yu, C.,Wei, Z. Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J.Biol.Chem. 2019 294 5896 5906 6IXQ 30804213 Structure of Myo2-GTD in complex with Smy1 2018-12-11 2019-03-06 Tang, K.,Li, Y.,Yu, C.,Wei, Z. Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J.Biol.Chem. 2019 294 5896 5906 6IXR 30804213 Structure of Myo2-GTD in complex with Inp2 2018-12-11 2019-03-06 Tang, K.,Li, Y.,Yu, C.,Wei, Z. Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. J.Biol.Chem. 2019 294 5896 5906 6J0Z 30739782 Crystal structure of AlpK 2018-12-27 2019-03-06 Wang, W.,Li, J.,Li, H.,Fan, K.,Liu, Y. Crystal structure of AlpK: An essential monooxygenase involved in the biosynthesis of kinamycin Biochem. Biophys. Res. Commun. 2019 510 601 605 6J6F 30670555 Ligand binding domain 1 and 2 of Talaromyces marneffei Mp1 protein 2019-01-15 2019-03-06 Lam, W.H.,Sze, K.H.,Ke, Y.,Tse, M.K.,Zhang, H.,Woo, P.C.Y.,Lau, S.K.P.,Lau, C.C.Y.,Xu, S.,Lai, P.M.,Zhou, T.,Antonyuk, S.V.,Kao, R.Y.T.,Yuen, K.Y.,Hao, Q. Talaromyces marneffeiMp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts. Infect. Immun. 2019 87 0 0 5XZ7 29940104 Crystal Structure of Phosphofructokinase from Staphylococcus aureus in complex with adenylylimidodiphosphate, the ATP analogue 2017-07-11 2019-03-13 Tian, T.,Wang, C.L.,Wu, M.H.,Zhang, X.,Zang, J.Y. Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion. Biochemistry 2018 57 4252 4262 5XZ9 29940104 Crystal Structure of Phosphofructokinase from Staphylococcus aureus in complex with adenylylimidodiphosphate, the ATP analogue 2017-07-12 2019-03-13 Tian, T.,Wang, C.L.,Wu, M.H.,Zhang, X.,Zang, J.Y. Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion. Biochemistry 2018 57 4252 4262 5XZA 29940104 Crystal Structure of Phosphofructokinase from Staphylococcus aureus in complex with ADP 2017-07-12 2019-03-13 Tian, T.,Wang, C.L.,Wu, M.H.,Zhang, X.,Zang, J.Y. Structural Insights into the Regulation of Staphylococcus aureus Phosphofructokinase by Tetramer-Dimer Conversion. Biochemistry 2018 57 4252 4262 5YXB A ligand binding to FXR 2017-12-04 2019-03-13 Yi, L.,Yong, L. A ligand binding to FXR To Be Published 0 0 0 0 5YXD A ligand F binding to FXR 2017-12-05 2019-03-13 Yi, L.,Yong, L. A ligand F binding to FXR To Be Published 0 0 0 0 5YXJ FXR ligand binding domain 2017-12-05 2019-03-13 Yi, L.,Yong, L. A ligand of drug binding to FXR To Be Published 0 0 0 0 5YXL A ligand M binding to FXR 2017-12-05 2019-03-13 Yi, L.,Yong, L. A ligand M binding to FXR To Be Published 0 0 0 0 5ZH0 Crystal Structures of Endo-beta-1,4-xylanase II 2018-03-10 2019-03-13 Zhang, X.,Wan, Q.,Li, Z. Crystal Structures of Endo-beta-1,4-xylanase II To be published 0 0 0 0 5ZQV 30422398 Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GM 2018-04-20 2019-03-13 Yu, J.,Deng, T.,Xiang, S. Structural basis for protein phosphatase 1 recruitment by glycogen-targeting subunits. FEBS J. 2018 285 4646 4659 6A9W 30739783 Structure of the bifunctional DNA primase-polymerase from phage NrS-1 2018-07-16 2019-03-13 Guo, H.J.,Li, M.J.,Wang, T.L.,Wu, H.,Zhou, H.,Xu, C.Y.,Liu, X.P.,Yu, F.,He, J.H. Crystal structure and biochemical studies of the bifunctional DNA primase-polymerase from phage NrS-1. Biochem. Biophys. Res. Commun. 2019 510 573 579 6AAY 30425321 the Cas13b binary complex 2018-07-19 2019-03-13 Zhang, B.,Ye, W.W.,Ye, Y.M.,Zhou, H.,Saeed, A.F.U.H.,Chen, J.,Lin, J.Y.,Perculija, V.,Chen, Q.,Chen, C.J.,Chang, M.X.,Choudhary, M.I.,Ouyang, S.Y. Structural insights into Cas13b-guided CRISPR RNA maturation and recognition. Cell Res. 2018 28 1198 1201 6ADW 30672289 Crystal structure of the Zika virus NS3 helicase (apo form) 2018-08-02 2019-03-13 Fang, J.,Jing, X.,Lu, G.,Xu, Y.,Gong, P. Crystallographic Snapshots of the Zika Virus NS3 Helicase Help Visualize the Reactant Water Replenishment. ACS Infect Dis 2019 5 177 183 6ADX 30672289 Crystal structure of the Zika virus NS3 helicase (ADP-Mn2+ complex, form 1) 2018-08-02 2019-03-13 Fang, J.,Jing, X.,Lu, G.,Xu, Y.,Gong, P. Crystallographic Snapshots of the Zika Virus NS3 Helicase Help Visualize the Reactant Water Replenishment. ACS Infect Dis 2019 5 177 183 6ADY 30672289 Crystal structure of the Zika virus NS3 helicase (ADP-Mn2+ complex, form 2) 2018-08-02 2019-03-13 Fang, J.,Jing, X.,Lu, G.,Xu, Y.,Gong, P. Crystallographic Snapshots of the Zika Virus NS3 Helicase Help Visualize the Reactant Water Replenishment. ACS Infect Dis 2019 5 177 183 6IFE 31387037 A Glycoside Hydrolase Family 43 beta-Xylosidase 2018-09-20 2019-03-13 Zhang, R.,Li, N.,Liu, Y.,Han, X.,Tu, T.,Shen, J.,Xu, S.,Wu, Q.,Zhou, J.,Huang, Z. Biochemical and structural properties of a low-temperature-active glycoside hydrolase family 43 beta-xylosidase: Activity and instability at high neutral salt concentrations. Food Chem 2019 301 125266 125266 6IH6 Phosphite Dehydrogenase mutant I151R/P176R/M207A from Ralstonia sp. 4506 in complex with non-natural cofactor Nicotinamide Cytosine dinucleotide 2018-09-28 2019-03-13 Liu, Y.,Feng, Y.,Wang, L.,Guo, X.,Liu, W.,Li, Q.,Wang, X.,Xue, S.,Zhao, Z. Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor Acs Catalysis 2019 9 1883 1887 6IH8 Crystal structure of Phosphite Dehydrogenase mutant I151R/P176R/M207A from Ralstonia sp. 4506 2018-09-28 2019-03-13 Liu, Y.,Feng, Y.,Wang, L.,Guo, X.,Liu, W.,Li, Q.,Wang, X.,Xue, S.,Zhao, Z. Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor Acs Catalysis 2019 9 1883 1887 6IPO 30770832 Ferritin mutant C90A/C102A/C130A/D144C 2018-11-03 2019-03-13 Zang, J.,Chen, H.,Zhang, X.,Zhang, C.,Guo, J.,Du, M.,Zhao, G. Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages. Nat Commun 2019 10 778 778 6IPP 30770832 Non-native ferritin 8-mer mutant-C90A/C102A/C130A/D144C 2018-11-03 2019-03-13 Zang, J.,Chen, H.,Zhang, X.,Zhang, C.,Guo, J.,Du, M.,Zhao, G. Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages. Nat Commun 2019 10 778 778 6IYY 30797857 Crystal structure of human WIPI3,loop deletion mutant 2018-12-17 2019-03-13 Liang, R.,Ren, J.,Zhang, Y.,Feng, W. Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins. J. Mol. Biol. 2019 431 1494 1505 6JCC structure of a de novo protein D_1CY5_M1 2019-01-28 2019-03-13 Meng, W.,Haiyan, L. structure of a computationally designed mutant protein D_1CY5_M1 To Be Published 0 0 0 0 6JE8 30846208 crystal structure of a beta-N-acetylhexosaminidase 2019-02-04 2019-03-13 Chen, X.,Wang, J.,Liu, M.,Yang, W.,Wang, Y.,Tang, R.,Zhang, M. Crystallographic evidence for substrate-assisted catalysis of beta-N-acetylhexosaminidas from Akkermansia muciniphila. Biochem. Biophys. Res. Commun. 2019 511 833 839 6JEB 30846208 crystal structure of a beta-N-acetylhexosaminidase 2019-02-05 2019-03-13 Chen, X.,Wang, J.,Liu, M.,Yang, W.,Wang, Y.,Tang, R.,Zhang, M. Crystallographic evidence for substrate-assisted catalysis of beta-N-acetylhexosaminidas from Akkermansia muciniphila. Biochem. Biophys. Res. Commun. 2019 511 833 839 5YRQ 27001510 Crystal structure of Rad5 and Rev1 2017-11-09 2019-03-20 Xu, X.,Lin, A.Y.,Zhou, C.Y.,Blackwell, S.R.,Zhang, Y.R.,Wang, Z.H.,Feng, Q.Q.,Guan, R.F.,Hanna, M.D.,Chen, Z.C.,Xiao, W. Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1. Nucleic Acids Res. 2016 44 5231 5245 5Z33 Crystal structure of Mitogen-activated Protein Kinase Mps1 in Magnaporthe oryzae 2018-01-05 2019-03-20 Zhou, F.,Peng, J.B.,Zhao, Y.X.,Chen, X.,Zhang, Y.Y.,Peng, Y.L.,Liu, J.F.,Zhang, G.Z. Crystal structure of Mitogen-activated Protein Kinase Mps1 in Magnaporthe oryzae To Be Published 0 0 0 0 5ZFL 32576842 Crystal structure of beta-lactamase PenP mutant E166Y 2018-03-06 2019-03-20 He, Y.,Lei, J.,Pan, X.,Huang, X.,Zhao, Y. The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis. Sci Rep 2020 10 10205 10205 5ZID Crystal Structure of human DPP-IV in complex with HL2 2018-03-14 2019-03-20 Zhu, L.,Li, H.,Wu, F. Crystal Structure of human DPP-IV in complex with HL2 To Be Published 0 0 0 0 5ZII Crystal Structures of Mutant Endo-beta-1,4-xylanase II (Y88F)Complexed with Xylotriose 2018-03-15 2019-03-20 Wan, Q.,Zhang, X. Crystal Structures of Endo-beta-1,4-xylanase II to be published 0 0 0 0 5ZIO Crystal structure of NDM-1 in complex with L-captopril 2018-03-16 2019-03-20 Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors Bioorg.Med.Chem. 2020 29 0 0 5ZJ1 Crystal structure of NDM-1 in complex with D-captopril derivative CYT-14 2018-03-18 2019-03-20 Zhang, H.,Hao, Q. Crystal structure of NDM-1 to be published 0 0 0 0 5ZJ2 Crystal structure of NDM-1 in complex with D-captopril 2018-03-18 2019-03-20 Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors Bioorg.Med.Chem. 2020 29 0 0 5ZJ7 Crystal structure of NDM-1 in complex with D-captopril derivative CY22 2018-03-19 2019-03-20 Zhang, H.,Hao, Q. Crystal structure of NDM-1 to be published 0 0 0 0 5ZJ8 Crystal structure of NDM-1 in complex with D-captopril derivative CY32 2018-03-19 2019-03-20 Zhang, H.,Hao, Q. Crystal structure of NDM-1 to be published 0 0 0 0 5ZJC Crystal structure of NDM-1 in complex with D-captopril derivative CY41 2018-03-20 2019-03-20 Zhang, H.,Hao, Q. Crystal structure of NDM-1 to be published 0 0 0 0 5ZR6 29730293 Manganese-dependent transcriptional repressor complex with manganese 2018-04-23 2019-03-20 Cong, X.Y.,Yuan, Z.L.,Wang, Z.,Wei, B.,Xu, S.J.,Wang, J.B. Crystal structures of manganese-dependent transcriptional repressor MntR (Rv2788) from Mycobacterium tuberculosis in apo and manganese bound forms. Biochem. Biophys. Res. Commun. 2018 501 423 427 5ZX2 30858373 Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ECF sigma factor sigma H and 7nt RNA 2018-05-17 2019-03-20 Li, L.,Fang, C.,Zhuang, N.,Wang, T.,Zhang, Y. Structural basis for transcription initiation by bacterial ECF sigma factors. Nat Commun 2019 10 1153 1153 5ZX3 30858373 Mycobacterium tuberculosis RNA polymerase holoenzyme with ECF sigma factor sigma H 2018-05-17 2019-03-20 Li, L.,Fang, C.,Zhuang, N.,Wang, T.,Zhang, Y. Structural basis for transcription initiation by bacterial ECF sigma factors. Nat Commun 2019 10 1153 1153 5ZG9 30561148 Crystal structure of MoSub1-ssDNA complex in phosphate buffer 2018-03-08 2019-03-27 Zhao, Y.,Zhang, Y.,Huang, J.,Wang, S.,Yi, L.,Zhang, X.,Xu, M.,Fang, X.,Liu, J. The effect of phosphate ion on the ssDNA binding mode of MoSub1, a Sub1/PC4 homolog from rice blast fungus. Proteins 2019 87 257 264 5ZKM 31713614 Crystal structure of Streptococcus pneumoniae SP_0782 (residues 7-79) in complex with single-stranded DNA TCTTCC 2018-03-24 2019-03-27 Li, S.,Lu, G.,Fang, X.,Ramelot, T.A.,Kennedy, M.A.,Zhou, X.,Gong, P.,Zhang, X.,Liu, M.,Zhu, J.,Yang, Y. Structural insight into the length-dependent binding of ssDNA by SP_0782 from Streptococcus pneumoniae, reveals a divergence in the DNA-binding interface of PC4-like proteins. Nucleic Acids Res. 2020 48 432 444 5ZKT Crystal structure of TCP domain of PCF6 in Oryza sativa 2018-03-26 2019-03-27 Sun, L.F.,Zou, X.M. Crystal structure of TCP domain of PCF6 in Oryza sativa To be published 0 0 0 0 6A37 X-ray structure of cyclohexanone monooxygenase from Acinetobacter calcoaceticus 2018-06-15 2019-03-27 Zhang, Y.,Wu, Y.Q.,Xu, N.,Zhao, Q.,Yu, H.L.,Xu, J.H. Engineering of Cyclohexanone Monooxygenase for the Enantioselective Synthesis of (S)-Omeprazole Acs Sustain Chem Eng 0 0 0 0 6FWB 30591370 Crystal structure of Mat2A at 1.79 Angstron resolution 2018-03-06 2019-03-27 Bai, J.,Gao, Y.,Chen, L.,Yin, Q.,Lou, F.,Wang, Z.,Xu, Z.,Zhou, H.,Li, Q.,Cai, W.,Sun, Y.,Niu, L.,Wang, H.,Wei, Z.,Lu, S.,Zhou, A.,Zhang, J.,Wang, H. Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes. Ebiomedicine 2019 39 575 590 6N3I 30854221 Crystal structure of a double Trp XylE mutants (G58W/L315W) 2018-11-15 2019-03-27 Jiang, X.,Wu, J.,Ke, M.,Zhang, S.,Yuan, Y.,Lin, J.Y.,Yan, N. Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs. Cell Discov 2019 5 14 14 5ZGC Crystal Structure of SIRT3 in complex with H4K16bhb peptide 2018-03-08 2019-04-03 Li, H.,Zhang, X. Crystal Structure of SIRT3 in complex with H4K16bhb peptide To be published 0 0 0 0 5ZGD 31043593 hnRNPA1 reversible amyloid core GFGGNDNFG (residues 209-217) determined by X-ray 2018-03-08 2019-04-03 Gui, X.,Luo, F.,Li, Y.,Zhou, H.,Qin, Z.,Liu, Z.,Gu, J.,Xie, M.,Zhao, K.,Dai, B.,Shin, W.S.,He, J.,He, L.,Jiang, L.,Zhao, M.,Sun, B.,Li, X.,Liu, C.,Li, D. Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun 2019 10 2006 2006 5ZGL 31043593 hnRNP A1 segment GGGYGGS (residues 234-240) 2018-03-09 2019-04-03 Gui, X.,Luo, F.,Li, Y.,Zhou, H.,Qin, Z.,Liu, Z.,Gu, J.,Xie, M.,Zhao, K.,Dai, B.,Shin, W.S.,He, J.,He, L.,Jiang, L.,Zhao, M.,Sun, B.,Li, X.,Liu, C.,Li, D. Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun 2019 10 2006 2006 5ZLZ Structure of tPA and PAI-1 2018-03-31 2019-04-03 Min, L.,Huang, M. Development of a PAI-1 trapping agent (PAItrap2) based on inactivated tPA-SPD and the crystal structure of PAItrap2 in complex with PAI-1 To Be Published 0 0 0 0 6IWT 30934718 Crystal structure of methyltransferase COMT-S in P. praeruptorum 2018-12-06 2019-04-03 Zhao, Y.,Wang, N.,Sui, Z.,Huang, C.,Zeng, Z.,Kong, L. The Molecular and Structural Basis ofO-methylation Reaction in Coumarin Biosynthesis inPeucedanum praeruptorumDunn. Int J Mol Sci 2019 20 0 0 5Z5L Crystal structure of ConA-R5M 2018-01-18 2019-04-10 Hu, R.T.,Gan, J.H.,Chen, G.S. Crystal structure of ConA-R5M To Be Published 0 0 0 0 5ZKZ Crystal Structures of Mutant Endo-beta-1,4-xylanase II(Y77F) Complexed with Xylotriose 2018-03-26 2019-04-10 Wan, Q.,Zhang, X. Crystal Structures of Endo-beta-1,4-xylanase II to be published 0 0 0 0 5ZO3 30666241 apo form of the nuclease 2018-04-12 2019-04-10 Yuan, Z.,Gao, F.,Yin, K.,Gu, L. NrnC, an RNase D-Like Protein FromAgrobacterium, Is a Novel Octameric Nuclease That Specifically Degrades dsDNA but Leaves dsRNA Intact. Front Microbiol 2018 9 3230 3230 5ZO4 30666241 inactive state of the nuclease 2018-04-12 2019-04-10 Yuan, Z.,Gao, F.,Yin, K.,Gu, L. NrnC, an RNase D-Like Protein FromAgrobacterium, Is a Novel Octameric Nuclease That Specifically Degrades dsDNA but Leaves dsRNA Intact. Front Microbiol 2018 9 3230 3230 5ZO5 30666241 active state of the nuclease 2018-04-12 2019-04-10 Yuan, Z.,Gao, F.,Yin, K.,Gu, L. NrnC, an RNase D-Like Protein FromAgrobacterium, Is a Novel Octameric Nuclease That Specifically Degrades dsDNA but Leaves dsRNA Intact. Front Microbiol 2018 9 3230 3230 6IUF 30936526 Crystal structure of Anti-CRISPR protein AcrVA5 2018-11-28 2019-04-10 Dong, L.,Guan, X.,Li, N.,Zhang, F.,Zhu, Y.,Ren, K.,Yu, L.,Zhou, F.,Han, Z.,Gao, N.,Huang, Z. An anti-CRISPR protein disables type V Cas12a by acetylation. Nat. Struct. Mol. Biol. 2019 26 308 314 5ZOA The crystal structure of a Thermobifida fusca cutinase 2018-04-12 2019-04-17 Dong, Q.L.,Wu, L.,Wu, J.,Zhou, J.H. The crystal structure of a cutinase from Thermobifida fusca To Be Published 0 0 0 0 6AE8 31107867 Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement 2018-08-03 2019-04-17 Wang, Y.,Liu, S.,Sun, L.,Xu, N.,Shan, S.,Wu, F.,Liang, X.,Huang, Y.,Luk, E.,Wu, C.,Zhou, Z. Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement. Plos Biol. 2019 17 0 0 6J1K Crystal structure of ribose-5-phosphate isomerase A from Ochrobactrum sp. CSL1 2018-12-28 2019-04-17 Xu, X.Q.,Mo, X.B.,Ju, X.,Shen, M.,Li, L.Z.,Yuan, A.Y. Crystal structure of ribose-5-phosphate isomerase A from Ochrobactrum sp. CSL1 To be published 0 0 0 0 5ZQI Alginate lyase AlgAT5 from Polysaccharide Lyase family 7 2018-04-19 2019-04-24 Su, H.,Dong, S.,Feng, Y.G.,Ji, S.Q.,Lu, M.,Li, F.L. Alginate lyase AlgAT5 from Polysaccharide Lyase family 7 To Be Published 0 0 0 0 6IIT Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me2-containing histone peptide 2018-10-07 2019-04-24 Wang, Z.,Tian, W. Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and a H3K36me2-containing histone peptide Nucleic Acids Res. 2019 0 0 0 6J4R 30974511 Structural basis for the target DNA recognition and binding by the MYB domain of phosphate starvation response regulator 1 2019-01-10 2019-04-24 Jiang, M.,Sun, L.,Isupov, M.N.,Littlechild, J.A.,Wu, X.,Wang, Q.,Wang, Q.,Yang, W.,Wu, Y. Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1. Febs J. 2019 286 2809 2821 6AC0 30979585 Crystal structure of TRADD death domain GlcNAcylated by EPEC effector NleB 2018-07-24 2019-05-01 Ding, J.,Pan, X.,Du, L.,Yao, Q.,Xue, J.,Yao, H.,Wang, D.C.,Li, S.,Shao, F. Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector. Mol.Cell 2019 74 922 0 6AC5 30979585 Crystal structure of RIPK1 death domain GlcNAcylated by EPEC effector NleB 2018-07-25 2019-05-01 Ding, J.,Pan, X.,Du, L.,Yao, Q.,Xue, J.,Yao, H.,Wang, D.C.,Li, S.,Shao, F. Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector. Mol.Cell 2019 74 922 0 6ACI 30979585 Crystal structure of EPEC effector NleB in complex with FADD death domain 2018-07-26 2019-05-01 Ding, J.,Pan, X.,Du, L.,Yao, Q.,Xue, J.,Yao, H.,Wang, D.C.,Li, S.,Shao, F. Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector. Mol.Cell 2019 74 922 0 6J3O 30998845 Crystal structure of the human PCAF bromodomain in complex with compound 12 2019-01-05 2019-05-01 Huang, L.,Li, H.,Li, L.,Niu, L.,Seupel, R.,Wu, C.,Cheng, W.,Chen, C.,Ding, B.,Brennan, P.E.,Yang, S. Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J.Med.Chem. 2019 62 4526 4542 6H86 31023827 Rebuilt and re-refined PDB entry 4R3Q: Crystal structure of SYCE3 2018-08-02 2019-05-08 Dunne, O.M.,Davies, O.R. A molecular model for self-assembly of the synaptonemal complex protein SYCE3. J.Biol.Chem. 2019 294 9260 9275 5ZWK Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with fructose-1,6-bisphophate and AMP 2018-05-15 2019-05-15 Yunyuan, H.,Zeyuan, G.,Junjie, Y.,Ping, Y.,Jian, W.,Li, R. Location of FBPase catalytic metal binding site: a combined experimental and theoretical study To Be Published 0 0 0 0 6JEP 30893607 Structure of a neutralizing antibody bound to the Zika envelope protein domain III 2019-02-07 2019-05-15 Wang, L.,Wang, R.,Wang, L.,Ben, H.,Yu, L.,Gao, F.,Shi, X.,Yin, C.,Zhang, F.,Xiang, Y.,Zhang, L. Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep 2019 26 3360 0 6JKZ 31073025 Crystal structure of VvPlpA from Vibrio vulnificus 2019-03-03 2019-05-15 Wan, Y.,Liu, C.,Ma, Q. Structural analysis of aVibriophospholipase reveals an unusual Ser-His-chloride catalytic triad. J.Biol.Chem. 2019 294 11391 11401 6JO7 31080063 Crystal structure of mouse MXRA8 2019-03-20 2019-05-15 Song, H.,Zhao, Z.,Chai, Y.,Jin, X.,Li, C.,Yuan, F.,Liu, S.,Gao, Z.,Wang, H.,Song, J.,Vazquez, L.,Zhang, Y.,Tan, S.,Morel, C.M.,Yan, J.,Shi, Y.,Qi, J.,Gao, F.,Gao, G.F. Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. Cell 2019 177 1714 0 5XRD Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7 2017-06-08 2019-05-22 Li, J.,Shi, F.,Xiong, B.,He, J.H. Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FS7 To Be Published 0 0 0 0 5ZQG Complex structure of PEDV 3CLpro mutant (C144A) with NEMO-231 peptite substrate 2018-04-18 2019-05-22 Gang, Y.,Chen, J.Y. Complex structure of PEDV 3CLpro mutant (C144A) with NEMO peptite substrate To Be Published 0 0 0 0 5ZS0 Structure of glycoprotein B Domain IV of pseudorabies virus with 7B11 antibody 2018-04-26 2019-05-22 Hu, X.L.,Peng, R.C.,Li, X.D. Structural Basis for the Recognition of Pseudorabies Virus Glycoprotein B by a Complement-dependent Neutralizing Antibody To Be Published 0 0 0 0 5ZX1 30293681 Crystal structure of ENT domain from T. brucei 2018-05-17 2019-05-22 Mi, J.,Yang, X.,Zhang, J.,Zhang, X.,Xu, C.,Liao, S.,Tu, X. Crystal structure of an ENT domain from Trypanosoma brucei. Biochem.Biophys.Res.Commun. 2018 505 755 760 5ZXH The structure of MT189-tubulin complex 2018-05-21 2019-05-22 Li, Z.P.,Ma, L.L.,Wu, C.Y.,Meng, T.,Ma, L.P.,Zheng, W.,Yu, Y.,Chen, Q.,Yang, J.L.,Shen, J.G. The Structure of MT189-Tubulin Complex Provides Insights into Drug Design Lett.Drug Des.Discovery 2019 0 0 0 5ZY5 spCOMT apo structure 2018-05-22 2019-05-22 Wang, Q.,Li, X. structural and functional investigations of spCOMT To Be Published 0 0 0 0 5ZNJ 36394909 Crystal structure of a bacterial ProRS with ligands 2018-04-09 2019-05-29 Cheng, B.,Cai, Z.,Luo, Z.,Luo, S.,Luo, Z.,Cheng, Y.,Yu, Y.,Guo, J.,Ju, Y.,Gu, Q.,Xu, J.,Jiang, X.,Li, G.,Zhou, H. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J.Med.Chem. 2022 65 15840 15855 5ZNK 36394909 Crystal structure of a bacterial ProRS with ligands 2018-04-09 2019-05-29 Cheng, B.,Cai, Z.,Luo, Z.,Luo, S.,Luo, Z.,Cheng, Y.,Yu, Y.,Guo, J.,Ju, Y.,Gu, Q.,Xu, J.,Jiang, X.,Li, G.,Zhou, H. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J.Med.Chem. 2022 65 15840 15855 6JCY 31131408 Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a chimeric ECF sigma factor sigH/E 2019-01-30 2019-05-29 Fang, C.,Li, L.,Shen, L.,Shi, J.,Wang, S.,Feng, Y.,Zhang, Y. Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res. 2019 47 7094 7104 6K2Q 31274299 Aeromonas hydrophila MtaN-2 complexed with adenine 2019-05-15 2019-05-29 Chen, J.,Liu, W.,Wang, L.,Shang, F.,Chen, Y.,Lan, J.,Gao, P.,Ha, N.C.,Quan, C.,Nam, K.H.,Xu, Y. Crystal Structure of Aeromonas hydrophila Cytoplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase. Biochemistry 2019 58 3136 3143 6JYX 31104766 Structure of CbpJ from Streptococcus Pneumoniae TIGR4 2019-04-29 2019-06-05 Xu, Q.,Zhang, J.W.,Chen, Y.,Li, Q.,Jiang, Y.L. Crystal structure of the choline-binding protein CbpJ from Streptococcus pneumoniae. Biochem.Biophys.Res.Commun. 2019 514 1192 1197 5YL6 Crystal structure of Ofd2 in complex with 2OG from Schizosaccharomyces pombe 2017-10-17 2019-06-12 Wang, J.,Gao, Y.X.,Guo, G.R.,Zhu, Z.L.,Niu, L.W.,Teng, M.K. Crystal structure of Ofd2 in complex with 2OG from Schizosaccharomyces pombe to be published 0 0 0 0 5ZU4 Crystal structure of Lamprey immune protein 2018-05-06 2019-06-12 Li, Q.W.,Pang, Y. Structure of a pore-forming protein To Be Published 0 0 0 0 5ZUM Structure of dipeptidyl-peptidase III from Corallococcus sp. strain EGB 2018-05-08 2019-06-12 Zhang, H.,Duan, Y.J.,Li, Z.K.,Liu, W.D.,Huang, Y.,Cui, Z.L. Structure of dipeptidyl peptidase III from Corallococcus sp. strain EGB To Be Published 0 0 0 0 6JKP 31123167 Crystal structure of sulfoacetaldehyde reductase from Bifidobacterium kashiwanohense in complex with NAD+ 2019-03-01 2019-06-12 Zhou, Y.,Wei, Y.,Nanjaraj Urs, A.N.,Lin, L.,Xu, T.,Hu, Y.,Ang, E.L.,Zhao, H.,Yuchi, Z.,Zhang, Y. Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacteriumBifidobacterium kashiwanohense. Biosci.Rep. 2019 39 0 0 6JNY 31266960 Crystal structure of bacteriophage 21 Q protein 2019-03-18 2019-06-12 Shi, J.,Gao, X.,Tian, T.,Yu, Z.,Gao, B.,Wen, A.,You, L.,Chang, S.,Zhang, X.,Zhang, Y.,Feng, Y. Structural basis of Q-dependent transcription antitermination. Nat Commun 2019 10 2925 2925 6K1Z 31216343 Crystal structure of farnesylated hGBP1 2019-05-13 2019-06-12 Ji, C.,Du, S.,Li, P.,Zhu, Q.,Yang, X.,Long, C.,Yu, J.,Shao, F.,Xiao, J.Y. Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8. Plos Pathog. 2019 15 0 0 6K2D 31216343 The crystal structure of GBP1 with LRR domain of IpaH9.8 2019-05-14 2019-06-12 Ji, C.,Du, S.,Li, P.,Zhu, Q.,Yang, X.,Long, C.,Yu, J.,Shao, F.,Xiao, J.Y. Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8. Plos Pathog. 2019 15 0 0 6QYY 31147544 The crystal structure of head fiber gp8.5 N base in bacteriophage phi29 2019-03-10 2019-06-12 Xu, J.,Wang, D.,Gui, M.,Xiang, Y. Structural assembly of the tailed bacteriophage φ29. Nat Commun 2019 10 2366 2366 5YUP 31294329 Crystal Structure of the Fab fragment of FVIIa antibody mAb4F5 2017-11-22 2019-06-19 Jiang, L.G.,Xie, X.,Li, J.,Persson, E.,Huang, M.D. Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism. Res Pract Thromb Haemost 2019 3 412 419 5YUP 31294329 Crystal Structure of the Fab fragment of FVIIa antibody mAb4F5 2017-11-22 2019-06-19 Jiang, L.G.,Xie, X.,Li, J.,Persson, E.,Huang, M.D. Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism. Res Pract Thromb Haemost 2019 3 412 419 6A03 31167783 Structure of pSTING complex 2018-06-05 2019-06-19 Cong, X.,Yuan, Z.,Du, Y.,Wu, B.,Lu, D.,Wu, X.,Zhang, Y.,Li, F.,Wei, B.,Li, J.,Wu, J.,Xu, S.,Wang, J.,Qi, J.,Shang, G.,Gu, L. Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J.Biol.Chem. 2019 294 11420 11432 6A04 31167783 Structure of pSTING complex 2018-06-05 2019-06-19 Cong, X.,Yuan, Z.,Du, Y.,Wu, B.,Lu, D.,Wu, X.,Zhang, Y.,Li, F.,Wei, B.,Li, J.,Wu, J.,Xu, S.,Wang, J.,Qi, J.,Shang, G.,Gu, L. Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J.Biol.Chem. 2019 294 11420 11432 6A05 31167783 Structure of pSTING complex 2018-06-05 2019-06-19 Cong, X.,Yuan, Z.,Du, Y.,Wu, B.,Lu, D.,Wu, X.,Zhang, Y.,Li, F.,Wei, B.,Li, J.,Wu, J.,Xu, S.,Wang, J.,Qi, J.,Shang, G.,Gu, L. Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J.Biol.Chem. 2019 294 11420 11432 6A06 31167783 Structure of pSTING complex 2018-06-05 2019-06-19 Cong, X.,Yuan, Z.,Du, Y.,Wu, B.,Lu, D.,Wu, X.,Zhang, Y.,Li, F.,Wei, B.,Li, J.,Wu, J.,Xu, S.,Wang, J.,Qi, J.,Shang, G.,Gu, L. Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J.Biol.Chem. 2019 294 11420 11432 6A6J 31399345 Crystal structure of Zebra fish Y-box protein1 (YB-1) Cold-shock domain in complex with 6mer m5C RNA 2018-06-28 2019-06-19 Yang, Y.,Wang, L.,Han, X.,Yang, W.L.,Zhang, M.,Ma, H.L.,Sun, B.F.,Li, A.,Xia, J.,Chen, J.,Heng, J.,Wu, B.,Chen, Y.S.,Xu, J.W.,Yang, X.,Yao, H.,Sun, J.,Lyu, C.,Wang, H.L.,Huang, Y.,Sun, Y.P.,Zhao, Y.L.,Meng, A.,Ma, J.,Liu, F.,Yang, Y.G. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol.Cell 2019 75 1188 0 6AEJ 30996080 Crystal structure of human FTO in complex with small-molecule inhibitors 2018-08-05 2019-06-19 Peng, S.,Xiao, W.,Ju, D.,Sun, B.,Hou, N.,Liu, Q.,Wang, Y.,Zhao, H.,Gao, C.,Zhang, S.,Cao, R.,Li, P.,Huang, H.,Ma, Y.,Wang, Y.,Lai, W.,Ma, Z.,Zhang, W.,Huang, S.,Wang, H.,Zhang, Z.,Zhao, L.,Cai, T.,Zhao, Y.L.,Wang, F.,Nie, Y.,Zhi, G.,Yang, Y.G.,Zhang, E.E.,Huang, N. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med 2019 11 0 0 6IV8 31186424 the selenomethionine(SeMet)-derived Cas13d binary complex 2018-12-02 2019-06-19 Zhang, B.,Ye, Y.,Ye, W.,Perculija, V.,Jiang, H.,Chen, Y.,Li, Y.,Chen, J.,Lin, J.,Wang, S.,Chen, Q.,Han, Y.S.,Ouyang, S. Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d. Nat Commun 2019 10 2544 2544 6IV9 31186424 the Cas13d binary complex 2018-12-02 2019-06-19 Zhang, B.,Ye, Y.,Ye, W.,Perculija, V.,Jiang, H.,Chen, Y.,Li, Y.,Chen, J.,Lin, J.,Wang, S.,Chen, Q.,Han, Y.S.,Ouyang, S. Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d. Nat Commun 2019 10 2544 2544 6IYF 31167783 Structure of pSTING complex 2018-12-15 2019-06-19 Cong, X.,Yuan, Z.,Du, Y.,Wu, B.,Lu, D.,Wu, X.,Zhang, Y.,Li, F.,Wei, B.,Li, J.,Wu, J.,Xu, S.,Wang, J.,Qi, J.,Shang, G.,Gu, L. Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J.Biol.Chem. 2019 294 11420 11432 6J8F 31171830 Crystal structure of SVBP-VASH1 with peptide mimic the C-terminal of alpha-tubulin 2019-01-18 2019-06-19 Liao, S.,Rajendraprasad, G.,Wang, N.,Eibes, S.,Gao, J.,Yu, H.,Wu, G.,Tu, X.,Huang, H.,Barisic, M.,Xu, C. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res. 2019 29 533 547 6J9H 31171830 Crystal structure of SVBP-VASH1 complex 2019-01-22 2019-06-19 Liao, S.,Rajendraprasad, G.,Wang, N.,Eibes, S.,Gao, J.,Yu, H.,Wu, G.,Tu, X.,Huang, H.,Barisic, M.,Xu, C. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res. 2019 29 533 547 6JBT 30892132 Complex structure of toripalimab-Fab and PD-1 2019-01-26 2019-06-19 Liu, H.,Guo, L.,Zhang, J.,Zhou, Y.,Zhou, J.,Yao, J.,Wu, H.,Yao, S.,Chen, B.,Chai, Y.,Qi, J.,Gao, G.F.,Tan, S.,Feng, H.,Yan, J. Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy. Mabs 2019 11 681 690 6A58 32257379 Structure of histone demethylase REF6 2018-06-22 2019-06-26 Tian, Z.,Li, X.,Li, M.,Wu, W.,Zhang, M.,Tang, C.,Li, Z.,Liu, Y.,Chen, Z.,Yang, M.,Ma, L.,Caba, C.,Tong, Y.,Lam, H.M.,Dai, S.,Chen, Z. Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms. Cell Discov 2020 6 17 17 6A5A 31291642 Crystal structure of plant Receptor-like Kinase ANX1 2018-06-22 2019-06-26 Xiao, Y.,Stegmann, M.,Han, Z.,DeFalco, T.A.,Parys, K.,Xu, L.,Belkhadir, Y.,Zipfel, C.,Chai, J. Mechanisms of RALF peptide perception by a heterotypic receptor complex. Nature 2019 572 270 274 6A5B 31291642 Crystal structure of plant Receptor-like Kinase FER 2018-06-23 2019-06-26 Xiao, Y.,Stegmann, M.,Han, Z.,DeFalco, T.A.,Parys, K.,Xu, L.,Belkhadir, Y.,Zipfel, C.,Chai, J. Mechanisms of RALF peptide perception by a heterotypic receptor complex. Nature 2019 572 270 274 6A5C 31291642 Crystal structure of plant Receptor-like Kinase ANX2 2018-06-23 2019-06-26 Xiao, Y.,Stegmann, M.,Han, Z.,DeFalco, T.A.,Parys, K.,Xu, L.,Belkhadir, Y.,Zipfel, C.,Chai, J. Mechanisms of RALF peptide perception by a heterotypic receptor complex. Nature 2019 572 270 274 6A5D 31291642 Crystal structure of plant Glycosylphosphatidylinositol-anchored Protein LLG1 2018-06-23 2019-06-26 Xiao, Y.,Stegmann, M.,Han, Z.,DeFalco, T.A.,Parys, K.,Xu, L.,Belkhadir, Y.,Zipfel, C.,Chai, J. Mechanisms of RALF peptide perception by a heterotypic receptor complex. Nature 2019 572 270 274 6A5E 31291642 Crystal structure of plant peptide RALF23 in complex with FER and LLG2 2018-06-23 2019-06-26 Xiao, Y.,Stegmann, M.,Han, Z.,DeFalco, T.A.,Parys, K.,Xu, L.,Belkhadir, Y.,Zipfel, C.,Chai, J. Mechanisms of RALF peptide perception by a heterotypic receptor complex. Nature 2019 572 270 274 6JKM 31201382 Crystal structure of BubR1 kinase domain 2019-03-01 2019-06-26 Huang, Y.,Lin, L.,Liu, X.,Ye, S.,Yao, P.Y.,Wang, W.,Yang, F.,Gao, X.,Li, J.,Zhang, Y.,Zhang, J.,Yang, Z.,Liu, X.,Yang, Z.,Zang, J.,Teng, M.,Wang, Z.,Ruan, K.,Ding, X.,Li, L.,Cleveland, D.W.,Zhang, R.,Yao, X. BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res. 2019 29 562 578 6JON 31176489 Crystal structures of phage NrS-1 N300-dNTPs-Mg2+ complex provide molecular mechanisms for substrate specificity 2019-03-22 2019-06-26 Guo, H.,Li, M.,Wu, H.,Wang, W.,Yu, F.,He, J. Crystal structures of phage NrS-1 N300-dNTPs-Mg2+complex provide molecular mechanisms for substrate specificity. Biochem.Biophys.Res.Commun. 2019 515 551 557 6JY5 31171360 Structure of CsoS4B from Halothiobacillus neapolitanus 2019-04-26 2019-06-26 Zhao, Y.Y.,Jiang, Y.L.,Chen, Y.,Zhou, C.Z.,Li, Q. Crystal structure of pentameric shell protein CsoS4B of Halothiobacillus neapolitanus alpha-carboxysome. Biochem.Biophys.Res.Commun. 2019 515 510 515 6A6C Crystal structure of carbohydrate-binding module family 56 beta-1,3-glucan binding domain 2018-06-27 2019-07-03 Qin, Z.,Lin, S. Crystal structure of carbohydrate-binding module family 56 beta-1,3-glucan binding domain To Be Published 0 0 0 0 6IHK 30677184 Structure of MMPA CoA ligase in complex with ADP 2018-09-30 2019-07-03 Shao, X.,Cao, H.Y.,Zhao, F.,Peng, M.,Wang, P.,Li, C.Y.,Shi, W.L.,Wei, T.D.,Yuan, Z.,Zhang, X.H.,Chen, X.L.,Todd, J.D.,Zhang, Y.Z. Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol.Microbiol. 2019 111 1057 1073 6IJB 30677184 Structure of 3-methylmercaptopropionate CoA ligase mutant K523A in complex with AMP and MMPA 2018-10-09 2019-07-03 Shao, X.,Cao, H.Y.,Zhao, F.,Peng, M.,Wang, P.,Li, C.Y.,Shi, W.L.,Wei, T.D.,Yuan, Z.,Zhang, X.H.,Chen, X.L.,Todd, J.D.,Zhang, Y.Z. Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol.Microbiol. 2019 111 1057 1073 6IJC 30677184 Structure of MMPA-CoA dehydrogenase from Roseovarius nubinhibens ISM 2018-10-09 2019-07-03 Shao, X.,Cao, H.Y.,Zhao, F.,Peng, M.,Wang, P.,Li, C.Y.,Shi, W.L.,Wei, T.D.,Yuan, Z.,Zhang, X.H.,Chen, X.L.,Todd, J.D.,Zhang, Y.Z. Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol.Microbiol. 2019 111 1057 1073 6IO4 31588287 Silver-bound Glyceraldehyde-3-phosphate dehydrogenase A 2018-10-29 2019-07-03 Wang, H.,Wang, M.,Yang, X.,Xu, X.,Hao, Q.,Yan, A.,Hu, M.,Lobinski, R.,Li, H.,Sun, H. Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis ofE. coli. Chem Sci 2019 10 7193 7199 6IO6 31588287 Silver-bound Glyceraldehyde-3-phosphate dehydrogenase A at non-catalytic site 2018-10-29 2019-07-03 Wang, H.,Wang, M.,Yang, X.,Xu, X.,Hao, Q.,Yan, A.,Hu, M.,Lobinski, R.,Li, H.,Sun, H. Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis ofE. coli. Chem Sci 2019 10 7193 7199 6IOJ 31588287 Glyceraldehyde-3-phosphate dehydrogenase A (apo-form) 2018-10-30 2019-07-03 Wang, H.,Wang, M.,Yang, X.,Xu, X.,Hao, Q.,Yan, A.,Hu, M.,Lobinski, R.,Li, H.,Sun, H. Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis ofE. coli. Chem Sci 2019 10 7193 7199 6IYR 31199122 Crystal Structure of the acyltransferase domain from module 8 of the salinomycin polyketide synthase 2018-12-17 2019-07-03 Zhang, F.,Shi, T.,Ji, H.,Ali, I.,Huang, S.,Deng, Z.,Min, Q.,Bai, L.,Zhao, Y.,Zheng, J. Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase. Biochemistry 2019 58 2978 2986 6JG5 31149347 Crystal structure of AimR 2019-02-13 2019-07-03 Guan, Z.Y.,Pei, K.,Wang, J.,Cui, Y.Q.,Zhu, X.,Su, X.,Zhou, Y.B.,Zhang, D.L.,Tang, C.,Yin, P.,Liu, Z.,Zou, T.T. Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage. Cell Discov 2019 5 29 29 6JG8 31149347 Crystal structure of AimR in complex with DNA 2019-02-13 2019-07-03 Guan, Z.Y.,Pei, K.,Wang, J.,Cui, Y.Q.,Zhu, X.,Su, X.,Zhou, Y.B.,Zhang, D.L.,Tang, C.,Yin, P.,Liu, Z.,Zou, T.T. Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage. Cell Discov 2019 5 29 29 6JJ7 Crystal structure of OsHXK6-Glc complex 2019-02-25 2019-07-03 He, C.,Wei, P.,Chen, J.,Wang, H.,Wan, Y.,Zhou, J.,Zhu, Y.,Huang, W.,Yin, L. Crystal structure of OsHXK6-Glc complex To Be Published 0 0 0 0 6JJ8 Crystal structure of OsHXK6-ATP-Mg2+ complex 2019-02-25 2019-07-03 He, C.,Wei, P.,Chen, J.,Wang, H.,Wan, Y.,Zhou, J.,Zhu, Y.,Huang, W.,Yin, L. Crystal structure of OsHXK6-ATP-Mg2+ complex To Be Published 0 0 0 0 6JJ9 Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex 2019-02-25 2019-07-03 He, C.,Wei, P.,Chen, J.,Wang, H.,Wan, Y.,Zhou, J.,Zhu, Y.,Huang, W.,Yin, L. Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex To Be Published 0 0 0 0 6JKJ 31204687 Crystal structure of human SPSB2 in the apo-state 2019-03-01 2019-07-03 Luo, Y.,Li, K.,Yang, J.,Zhang, D.,Zhou, Y.,Kuang, Z. Crystal structure of the SPRY domain of human SPSB2 in the apo state. Acta Crystallogr.,Sect.F 2019 75 412 418 6K3H 31243100 Crystallographic Analysis of Nucleoside Diphosphate Kinase (NDK) from Aspergillus Flavus 2019-05-18 2019-07-03 Wang, Y.,Wang, S.,Nie, X.,Yang, K.,Xu, P.,Wang, X.,Liu, M.,Yang, Y.,Chen, Z.,Wang, S. Molecular and structural basis of nucleoside diphosphate kinase-mediated regulation of spore and sclerotia development in the fungusAspergillus flavus. J.Biol.Chem. 2019 294 12415 12431 6K5L 31235769 The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli 2019-05-29 2019-07-03 Zhang, X.,Shen, Q.,Lei, Z.,Wang, Q.,Zheng, J.,Jia, Z. Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation. Sci Rep 2019 9 9198 9198 6K6L YGL082W-catalytic domain 2019-06-03 2019-07-03 Lu, L.,Guo, Y.,Wang, T.,Liang, L.,Zhao, S.,Wang, F.,Liu, L. Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop Sci China Chem 2019 0 0 0 6K7O 31213474 Complex structure of LILRB4 and h128-3 antibody 2019-06-08 2019-07-03 Gui, X.,Deng, M.,Song, H.,Chen, Y.,Xie, J.,Li, Z.,He, L.,Huang, F.,Xu, Y.,Anami, Y.,Yu, H.,Yu, C.,Li, L.,Yuan, Z.,Xu, X.,Wang, Q.,Chai, Y.,Huang, T.,Shi, Y.,Tsuchikama, K.,Liao, X.C.,Xia, N.,Gao, G.F.,Zhang, N.,Zhang, C.C.,An, Z. Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development. Cancer Immunol Res 2019 7 1244 1257 6A8O 30019481 Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16 2018-07-09 2019-07-10 Xu, M.,Chen, Y.,Xu, P.,Andreasen, P.A.,Jiang, L.,Li, J.,Huang, M. Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217. Febs Lett. 2018 592 2658 2667 6A8W Crystal structure of the FHA domain of Far9 2018-07-10 2019-07-10 Chen, M.,Zhou, Z.C. Topological Structure and Dynamic Assembly of the STRIPAK Complex To be published 0 0 0 0 6AK4 30996080 Crystal structure of human FTO in complex with small-molecule inhibitors 2018-08-30 2019-07-10 Peng, S.,Xiao, W.,Ju, D.,Sun, B.,Hou, N.,Liu, Q.,Wang, Y.,Zhao, H.,Gao, C.,Zhang, S.,Cao, R.,Li, P.,Huang, H.,Ma, Y.,Wang, Y.,Lai, W.,Ma, Z.,Zhang, W.,Huang, S.,Wang, H.,Zhang, Z.,Zhao, L.,Cai, T.,Zhao, Y.L.,Wang, F.,Nie, Y.,Zhi, G.,Yang, Y.G.,Zhang, E.E.,Huang, N. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med 2019 11 0 0 6FM4 31276392 The crystal structure of S. aureus Gyrase complex with ID-130 and DNA 2018-01-30 2019-07-10 Magaro, G.,Prati, F.,Garofalo, B.,Corso, G.,Furlotti, G.,Apicella, C.,Mangano, G.,D'Atanasio, N.,Robinson, D.,Di Giorgio, F.P.,Ombrato, R. Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens. J.Med.Chem. 2019 62 7445 7472 6IYO 31199122 Crystal Structure of the acyltransferase domain from the second module of the salinomycin polyketide synthase 2018-12-17 2019-07-10 Zhang, F.,Shi, T.,Ji, H.,Ali, I.,Huang, S.,Deng, Z.,Min, Q.,Bai, L.,Zhao, Y.,Zheng, J. Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase. Biochemistry 2019 58 2978 2986 6J66 31244815 Chondroitin sulfate/dermatan sulfate endolytic 4-O-sulfatase 2019-01-14 2019-07-10 Wang, S.,Su, T.,Zhang, Q.,Guan, J.,He, J.,Gu, L.,Li, F. Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity. Front Microbiol 2019 10 1309 1309 6JLQ 31632687 Crystal structure of human USP46-WDR48-WDR20 complex 2019-03-06 2019-07-10 Zhu, H.,Zhang, T.,Wang, F.,Yang, J.,Ding, J. Structural insights into the activation of USP46 by WDR48 and WDR20. Cell Discov 2019 5 34 34 6IX7 31332284 The structure of LepI C52A in complex with SAH and substrate analogue 2018-12-09 2019-07-17 Cai, Y.,Hai, Y.,Ohashi, M.,Jamieson, C.S.,Garcia-Borras, M.,Houk, K.N.,Zhou, J.,Tang, Y. Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem. 2019 11 812 820 6IX7 31332284 The structure of LepI C52A in complex with SAH and substrate analogue 2018-12-09 2019-07-17 Cai, Y.,Hai, Y.,Ohashi, M.,Jamieson, C.S.,Garcia-Borras, M.,Houk, K.N.,Zhou, J.,Tang, Y. Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat.Chem. 2019 11 812 820 6JZD 31324789 Crystal structure of peptide-bound VASH2-SVBP complex 2019-05-01 2019-07-17 Zhou, C.,Yan, L.,Zhang, W.H.,Liu, Z. Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Nat Commun 2019 10 3212 3212 6ACL histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2AK95 2018-07-26 2019-07-24 Hang, T.R.,Chen, W.B. complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2AK95 To Be Published 0 0 0 0 6ACO histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2BK120 2018-07-26 2019-07-24 Hang, T.R.,Chen, W.B. complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2BK120 To Be Published 0 0 0 0 6IN8 31297938 Crystal structure of MucB 2018-10-24 2019-07-24 Li, S.,Lou, X.,Xu, Y.,Teng, X.,Liu, R.,Zhang, Q.,Wu, W.,Wang, Y.,Bartlam, M. Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa. Febs J. 2019 286 4982 4994 6IN9 31297938 Crystal structure of MucB in complex with MucA(peri) 2018-10-24 2019-07-24 Li, S.,Lou, X.,Xu, Y.,Teng, X.,Liu, R.,Zhang, Q.,Wu, W.,Wang, Y.,Bartlam, M. Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa. Febs J. 2019 286 4982 4994 6ISP 31324776 structure of Candida antarctica Lipase B mutant 2018-11-18 2019-07-24 Cen, Y.,Singh, W.,Arkin, M.,Moody, T.S.,Huang, M.,Zhou, J.,Wu, Q.,Reetz, M.T. Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. Nat Commun 2019 10 3198 3198 6ITQ 31049949 Crystal structure of cortisol complexed with its nanobody at pH 10.5 2018-11-24 2019-07-24 Ding, L.,Wang, Z.,Zhong, P.,Jiang, H.,Zhao, Z.,Zhang, Y.,Ren, Z.,Ding, Y. Structural insights into the mechanism of single domain VHH antibody binding to cortisol. Febs Lett. 2019 593 1248 1256 6J11 31296843 MERS-CoV spike N-terminal domain and 7D10 scFv complex 2018-12-27 2019-07-24 Zhou, H.,Chen, Y.,Zhang, S.,Niu, P.,Qin, K.,Jia, W.,Huang, B.,Zhang, S.,Lan, J.,Zhang, L.,Tan, W.,Wang, X. Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein. Nat Commun 2019 10 3068 3068 6J1X 31320636 WWP1 close conformation 2018-12-30 2019-07-24 Wang, Z.,Liu, Z.,Chen, X.,Li, J.,Yao, W.,Huang, S.,Gu, A.,Lei, Q.Y.,Mao, Y.,Wen, W. A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun 2019 10 3162 3162 6J1Y 31320636 Semi-open conformation E3 ligase 2018-12-30 2019-07-24 Wang, Z.,Liu, Z.,Chen, X.,Li, J.,Yao, W.,Huang, S.,Gu, A.,Lei, Q.Y.,Mao, Y.,Wen, W. A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun 2019 10 3162 3162 6J1Z 31320636 WWP2 semi-open conformation 2018-12-30 2019-07-24 Wang, Z.,Liu, Z.,Chen, X.,Li, J.,Yao, W.,Huang, S.,Gu, A.,Lei, Q.Y.,Mao, Y.,Wen, W. A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun 2019 10 3162 3162 6JBX 31291684 Crystal structure of Streptococcus pneumoniae FabT in complex with DNA 2019-01-27 2019-07-24 Zuo, G.,Chen, Z.P.,Jiang, Y.L.,Zhu, Z.,Ding, C.,Zhang, Z.,Chen, Y.,Zhou, C.Z.,Li, Q. Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP. Febs Lett. 2019 593 2730 2741 6JLE 31279628 Crystal structure of MORN4/Myo3a complex 2019-03-05 2019-07-24 Li, J.,Liu, H.,Raval, M.H.,Wan, J.,Yengo, C.M.,Liu, W.,Zhang, M. Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules. Structure 2019 27 1366 0 6K4K 31330531 Crystal structure of SidJ-CaM binary complex at 2.71 A 2019-05-24 2019-07-24 Gan, N.,Zhen, X.,Liu, Y.,Xu, X.,He, C.,Qiu, J.,Liu, Y.,Fujimoto, G.M.,Nakayasu, E.S.,Zhou, B.,Zhao, L.,Puvar, K.,Das, C.,Ouyang, S.,Luo, Z.Q. Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. Nature 2019 572 387 391 6K4L 31330531 Crystal structure of Se-labelled SidJ complex with CaM at 2.95 A 2019-05-24 2019-07-24 Gan, N.,Zhen, X.,Liu, Y.,Xu, X.,He, C.,Qiu, J.,Liu, Y.,Fujimoto, G.M.,Nakayasu, E.S.,Zhou, B.,Zhao, L.,Puvar, K.,Das, C.,Ouyang, S.,Luo, Z.Q. Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. Nature 2019 572 387 391 6K4R 31330531 Crystal structure of SidJ-CaM-AMP ternary complex at 3.11 A 2019-05-26 2019-07-24 Gan, N.,Zhen, X.,Liu, Y.,Xu, X.,He, C.,Qiu, J.,Liu, Y.,Fujimoto, G.M.,Nakayasu, E.S.,Zhou, B.,Zhao, L.,Puvar, K.,Das, C.,Ouyang, S.,Luo, Z.Q. Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. Nature 2019 572 387 391 6R2M 31282870 Crystal structure of PssZ from Listeria monocytogenes 2019-03-18 2019-07-24 Wu, H.,Qiao, S.,Li, D.,Guo, L.,Zhu, M.,Ma, L.Z. Crystal structure of the glycoside hydrolase PssZ from Listeria monocytogenes. Acta Crystallogr.,Sect.F 2019 75 501 506 6ABO 31548606 human XRCC4 and IFFO1 complex 2018-07-23 2019-07-31 Li, W.,Bai, X.,Li, J.,Zhao, Y.,Liu, J.,Zhao, H.,Liu, L.,Ding, M.,Wang, Q.,Shi, F.Y.,Hou, M.,Ji, J.,Gao, G.,Guo, R.,Sun, Y.,Liu, Y.,Xu, D. The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. Nat.Cell Biol. 2019 21 1273 1285 6AED 31273318 Crystal Structure of the four Ig-like domain of LILRB2(LIR2/ILT4/CD85d) 2018-08-04 2019-07-31 Wang, Q.,Song, H.,Cheng, H.,Qi, J.,Nam, G.,Tan, S.,Wang, J.,Fang, M.,Shi, Y.,Tian, Z.,Cao, X.,An, Z.,Yan, J.,Gao, G.F. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. Cell. Mol. Immunol. 2019 0 0 0 6AEE 31273318 Crystal structure of the four Ig-like domains of LILRB1 complexed with HLA-G 2018-08-04 2019-07-31 Wang, Q.,Song, H.,Cheng, H.,Qi, J.,Nam, G.,Tan, S.,Wang, J.,Fang, M.,Shi, Y.,Tian, Z.,Cao, X.,An, Z.,Yan, J.,Gao, G.F. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. Cell. Mol. Immunol. 2019 0 0 0 6IMQ 31439836 Crystal structure of PML B1-box multimers 2018-10-23 2019-07-31 Li, Y.,Ma, X.,Chen, Z.,Wu, H.,Wang, P.,Wu, W.,Cheng, N.,Zeng, L.,Zhang, H.,Cai, X.,Chen, S.J.,Chen, Z.,Meng, G. B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis. Nat Commun 2019 10 3789 3789 6IVC 31350335 The full length of TGEV nsp1 2018-12-03 2019-08-07 Shen, Z.,Wang, G.,Yang, Y.,Shi, J.,Fang, L.,Li, F.,Xiao, S.,Fu, Z.F.,Peng, G. A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence. J.Biol.Chem. 2019 294 13606 13618 6IVD 31350335 TGEV nsp1 mutant - 91-95sg 2018-12-03 2019-08-07 Shen, Z.,Wang, G.,Yang, Y.,Shi, J.,Fang, L.,Li, F.,Xiao, S.,Fu, Z.F.,Peng, G. A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence. J.Biol.Chem. 2019 294 13606 13618 6JQ1 31410466 Crystal Structure of DdrO from Deinococcus geothermalis 2019-03-28 2019-08-28 Lu, H.,Wang, L.,Li, S.,Pan, C.,Cheng, K.,Luo, Y.,Xu, H.,Tian, B.,Zhao, Y.,Hua, Y. Structure and DNA damage-dependent derepression mechanism for the XRE family member DG-DdrO. Nucleic Acids Res. 2019 47 9925 9933 6KCF 32423116 Structure of Inosine 5'-monophosphate Dehydrogenase from Candidatus Liberibacter asiaticus str. psy62 2019-06-28 2019-08-28 Nan, J.,Zhang, S.,Zhan, P.,Jiang, L. Evaluation of Bronopol and Disulfiram as Potential Candidatus Liberibacter asiaticus Inosine 5'-Monophosphate Dehydrogenase Inhibitors by Using Molecular Docking and Enzyme Kinetic. Molecules 2020 25 0 0 6KIN 31405562 Crystal structure of the tri-functional malyl-CoA lyase from Roseiflexus castenholzii 2019-07-19 2019-09-04 Tang, W.,Wang, Z.,Zhang, C.,Wang, C.,Min, Z.,Zhang, X.,Liu, D.,Shen, J.,Xu, X. The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii. Biochem.Biophys.Res.Commun. 2019 518 72 79 6J1M 31492848 Anisodus acutangulus type III polyketide sythase AaPKS2 in complex with 4-carboxy-3-oxobutanoyl covalent to C166 2018-12-28 2019-09-11 Huang, J.P.,Fang, C.,Ma, X.,Wang, L.,Yang, J.,Luo, J.,Yan, Y.,Zhang, Y.,Huang, S.X. Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation. Nat Commun 2019 10 4036 4036 6J1N 31492848 Anisodus acutangulus type III polyketide sythase AaPKS2 in complex with 4-carboxy-3-oxobutanoyl-CoA 2018-12-28 2019-09-11 Huang, J.P.,Fang, C.,Ma, X.,Wang, L.,Yang, J.,Luo, J.,Yan, Y.,Zhang, Y.,Huang, S.X. Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation. Nat Commun 2019 10 4036 4036 6J2P 31253666 Crystal structure of Saccharomyces cerevisiae Spp1 in complex with H3K4me3 2019-01-02 2019-09-11 He, C.,Liu, N.,Xie, D.,Liu, Y.,Xiao, Y.,Li, F. Structural basis for histone H3K4me3 recognition by the N-terminal domain of the PHD finger protein Spp1. Biochem.J. 2019 476 1957 1973 6IEV 31074908 Crystal structure of a designed protein 2018-09-17 2019-09-18 Han, M.,Liao, S.,Peng, X.,Zhou, X.,Chen, Q.,Liu, H. Selection and analyses of variants of a designed protein suggest importance of hydrophobicity of partially buried sidechains for protein stability at high temperatures. Protein Sci. 2019 28 1437 1447 6IEX 31226552 Crystal structure of HLA-B*4001 in complex with SARS-CoV derived peptide N216-225 GETALALLLL 2018-09-17 2019-09-18 Ji, W.,Niu, L.,Peng, W.,Zhang, Y.,Cheng, H.,Gao, F.,Shi, Y.,Qi, J.,Gao, G.F.,Liu, W.J. Salt bridge-forming residues positioned over viral peptides presented by MHC class I impacts T-cell recognition in a binding-dependent manner. Mol.Immunol. 2019 112 274 282 6IF4 31747559 Crystal structure of Tbtudor 2018-09-18 2019-09-18 Gao, J.,Ye, K.,Diwu, Y.,Xu, C.,Zhang, X.,Liao, S.,Tu, X. Crystal structure of TbEsa1 presumed Tudor domain from Trypanosoma brucei. J.Struct.Biol. 2020 209 107406 107406 6J4A Human H chain ferritin with an extension peptide 2019-01-08 2019-09-18 Zhang, X.,Zang, J.,Chen, H.,Zhou, K.,Zhang, T.,Lv, C.,Zhao, G. Thermostability of protein nanocages: the effect of natural extra peptide on the exterior surface Rsc Adv 2019 9 24777 24782 6J4J soybean seed H-2 ferritin 2019-01-09 2019-09-18 Zhang, X.,Zang, J.,Chen, H.,Zhou, K.,Zhang, T.,Lv, C.,Zhao, G. Thermostability of protein nanocages: the effect of natural extra peptide on the exterior surface. Rsc Adv 2019 9 24777 24782 6J4M Thermal treated soybean seed H-2 ferritin 2019-01-09 2019-09-18 Zhang, X.,Zang, J.,Chen, H.,Zhou, K.,Zhang, T.,Lv, C.,Zhao, G. Thermostability of protein nanocages: the effect of natural extra peptide on the exterior surface. Rsc Adv 2019 9 24777 24782 6JN2 31527241 Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10 2019-03-13 2019-09-18 Song, X.,Yang, L.,Wang, M.,Gu, Y.,Ye, B.,Fan, Z.,Xu, R.M.,Yang, N. A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity. Proc.Natl.Acad.Sci.USA 2019 116 19917 19923 6JYT 31131400 Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis 2019-04-28 2019-09-18 Jia, Z.,Yan, L.,Ren, Z.,Wu, L.,Wang, J.,Guo, J.,Zheng, L.,Ming, Z.,Zhang, L.,Lou, Z.,Rao, Z. Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis. Nucleic Acids Res. 2019 47 6538 6550 6KMS 31636962 Crystal structure of human N6amt1-Trm112 in complex with SAM (space group I422) 2019-08-01 2019-09-18 Li, W.,Shi, Y.,Zhang, T.,Ye, J.,Ding, J. Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. Cell Discov 2019 5 51 51 6ITE 30737033 Crystal structure of group A Streptococcal surface dehydrogenase (SDH) 2018-11-21 2019-09-25 Li, R.,Liang, C.,Jiang, L.,Yuan, C.,Huang, M. Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Biochem.Biophys.Res.Commun. 2019 510 539 544 6JGF 31548408 Crystal structure of Se-Met CadR from P. putida with a 21 residue C-terminal truncation 2019-02-13 2019-09-25 Liu, X.,Hu, Q.,Yang, J.,Huang, S.,Wei, T.,Chen, W.,He, Y.,Wang, D.,Liu, Z.,Wang, K.,Gan, J.,Chen, H. Selective cadmium regulation mediated by a cooperative binding mechanism in CadR. Proc.Natl.Acad.Sci.USA 2019 116 20398 20403 6JGV 31548408 Crystal structure of the transcriptional regulator CadR from P. putida 2019-02-15 2019-09-25 Liu, X.,Hu, Q.,Yang, J.,Huang, S.,Wei, T.,Chen, W.,He, Y.,Wang, D.,Liu, Z.,Wang, K.,Gan, J.,Chen, H. Selective cadmium regulation mediated by a cooperative binding mechanism in CadR. Proc.Natl.Acad.Sci.USA 2019 116 20398 20403 6JGW 31548408 Crystal structure of the transcriptional regulator CadR from P. putida in complex with DNA 2019-02-15 2019-09-25 Liu, X.,Hu, Q.,Yang, J.,Huang, S.,Wei, T.,Chen, W.,He, Y.,Wang, D.,Liu, Z.,Wang, K.,Gan, J.,Chen, H. Selective cadmium regulation mediated by a cooperative binding mechanism in CadR. Proc.Natl.Acad.Sci.USA 2019 116 20398 20403 6JGX 31548408 Crystal structure of the transcriptional regulator CadR from P. putida in complex with Cadmium(II) and DNA 2019-02-15 2019-09-25 Liu, X.,Hu, Q.,Yang, J.,Huang, S.,Wei, T.,Chen, W.,He, Y.,Wang, D.,Liu, Z.,Wang, K.,Gan, J.,Chen, H. Selective cadmium regulation mediated by a cooperative binding mechanism in CadR. Proc.Natl.Acad.Sci.USA 2019 116 20398 20403 6JJZ 31486770 Crystal Structure of MAGI2 and Dendrin complex 2019-02-27 2019-09-25 Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M. Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity. Elife 2019 8 0 0 6JNI 31548408 Crystal structure of the transcriptional regulator CadR from P. putida in complex with Zinc(II) and DNA 2019-03-16 2019-09-25 Liu, X.,Hu, Q.,Yang, J.,Huang, S.,Wei, T.,Chen, W.,He, Y.,Wang, D.,Liu, Z.,Wang, K.,Gan, J.,Chen, H. Selective cadmium regulation mediated by a cooperative binding mechanism in CadR. Proc.Natl.Acad.Sci.USA 2019 116 20398 20403 6KDY 31515270 Crystal structure of the alpha bata heterodimer of human IDH3 in complex with NAD. 2019-07-03 2019-09-25 Sun, P.,Ma, T.,Zhang, T.,Zhu, H.,Zhang, J.,Liu, Y.,Ding, J. Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase. J.Biol.Chem. 2019 294 16214 16227 6KE3 31515270 Crystal structure of the alpha bata heterodimer of human IDH3 in complex with NADH 2019-07-03 2019-09-25 Sun, P.,Ma, T.,Zhang, T.,Zhu, H.,Zhang, J.,Liu, Y.,Ding, J. Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase. J.Biol.Chem. 2019 294 16214 16227 6KFU A ACP-AMT Fusion Protein of Hybrid Polyketide/Non-Ribosomal Peptide Synthetase 2019-07-08 2019-09-25 Tian, Q.W.,Jiang, T. Structure Insights into the Molecular Mechanism of Two Tailoring Domains of Hybrid Polyketide/Non-Ribosomal Peptide Synthetase To Be Published 0 0 0 0 6IGN The crystal structure of Kif5b stalk 1 coiled-coil region 2018-09-25 2019-10-02 Zhang, S.J.,Sun, W.P.,Kong, B. The crystal structure of Kif5b stalk 1 coiled-coil region To Be Published 0 0 0 0 6JYZ 31557527 Crystal structure of endogalactoceramidase 2019-04-29 2019-10-02 Chen, L.,Chang, Q.,Yan, Q.,Yang, G.,Zhang, Y.,Feng, Y. Structure of an endogalactosylceramidase from Rhodococcus hoagii 103S reveals the molecular basis of its substrate specificity. J.Struct.Biol. 2019 208 107393 107393 6IGY 32275147 Crystal structure of Aspergillus niger chitinase B 2018-09-27 2019-10-09 Liu, T.,Han, H.,Wang, D.,Guo, X.,Zhou, Y.,Fukamizo, T.,Yang, Q. Potent Fungal Chitinase for the Bioconversion of Mycelial Waste. J.Agric.Food Chem. 2020 68 5384 5390 6K2N 31620994 Structural basis of glycan recognition in globally predominant human P[8] rotavirus 2019-05-15 2019-10-09 Sun, X.,Dang, L.,Li, D.,Qi, J.,Wang, M.,Chai, W.,Zhang, Q.,Wang, H.,Bai, R.,Tan, M.,Duan, Z. Structural Basis of Glycan Recognition in Globally Predominant Human P[8] Rotavirus. Virol Sin 2020 35 156 170 6K2O 31620994 Structural basis of glycan recognition in globally predominant human P[8] rotavirus 2019-05-15 2019-10-09 Sun, X.,Dang, L.,Li, D.,Qi, J.,Wang, M.,Chai, W.,Zhang, Q.,Wang, H.,Bai, R.,Tan, M.,Duan, Z. Structural Basis of Glycan Recognition in Globally Predominant Human P[8] Rotavirus. Virol Sin 2020 35 156 170 6KZC 31271959 crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide 2019-09-23 2019-10-09 Cui, S.,Wang, Y.,Wang, Y.,Tang, X.,Ren, X.,Zhang, L.,Xu, Y.,Zhang, Z.,Zhang, Z.M.,Lu, X.,Ding, K. Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. Eur.J.Med.Chem. 2019 179 470 482 6KZD 31271959 Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide 2019-09-23 2019-10-09 Cui, S.,Wang, Y.,Wang, Y.,Tang, X.,Ren, X.,Zhang, L.,Xu, Y.,Zhang, Z.,Zhang, Z.M.,Lu, X.,Ding, K. Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. Eur.J.Med.Chem. 2019 179 470 482 6IK4 31941905 A Novel M23 Metalloprotease Pseudoalterin from Deep-sea 2018-10-14 2019-10-16 Tang, B.L.,Yang, J.,Chen, X.L.,Wang, P.,Zhao, H.L.,Su, H.N.,Li, C.Y.,Yu, Y.,Zhong, S.,Wang, L.,Lidbury, I.,Ding, H.,Wang, M.,McMinn, A.,Zhang, X.Y.,Chen, Y.,Zhang, Y.Z. A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria. Nat Commun 2020 11 285 285 6J7G 30770832 Human H-ferritin mutant-C90A/C102A/C130A/D144C 2019-01-18 2019-10-16 Zang, J.,Chen, H.,Zhang, X.,Zhang, C.,Guo, J.,Du, M.,Zhao, G. Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages. Nat Commun 2019 10 778 778 6JH0 Crystal structure of cISG15/NS1B complex 2019-02-16 2019-10-16 Jiang, Y.N.,Wang, X.Q. Crystal structure of cISG15/NS1B complex To Be Published 0 0 0 0 6JIS 31129210 Crystal structure of the histidine racemase CntK in cobalt and nickel transporter system of staphylococcus aureus 2019-02-23 2019-10-16 Luo, S.,Ju, Y.,Zhou, J.,Gu, Q.,Xu, J.,Zhou, H. Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus. Int.J.Biol.Macromol. 2019 135 725 733 6JPM 31525411 Crystal Structure of Odorant Binding Protein 4 in the Natural Predator Chrysopa pallens 2019-03-27 2019-10-16 Li, T.T.,Liu, W.C.,Zhu, J.,Yang, Y.H.,Ma, C.,Lu, C.,Zhang, K.X. Crystal structure and ligand identification of odorant binding protein 4 in the natural predator Chrysopa pallens. Int.J.Biol.Macromol. 2019 141 1004 1012 6KY4 31604522 Crystal structure of Sulfiredoxin from Arabidopsis thaliana 2019-09-16 2019-10-16 Liu, M.,Wang, J.,Li, X.,Sylvanno, M.J.,Li, M.,Zhang, M.,Wang, M. The crystal structure of sulfiredoxin from Arabidopsis thaliana revealed a more robust antioxidant mechanism in plants. Biochem.Biophys.Res.Commun. 2019 520 347 352 6IND 31099559 Crystal structure of PDE4D complexed with a novel inhibitor 2018-10-24 2019-10-23 Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y. Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem. 2019 62 5579 5593 6INM 31099559 Crystal structure of PDE4D complexed with a novel inhibitor 2018-10-26 2019-10-23 Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y. Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem. 2019 62 5579 5593 6KNV 31655060 THRb mutation with a novel agonist 2019-08-07 2019-10-23 Yao, B.,Wei, Y.,Zhang, S.,Tian, S.,Xu, S.,Wang, R.,Zheng, W.,Li, Y. Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience 2019 20 489 496 6INX Structural insights into a novel glycoside hydrolase family 18 N-acetylglucosaminidase from Paenibacillus barengoltzii 2018-10-28 2019-10-30 Jiang, Z.Q.,Ma, J.W.,Huang, P. Structural insights into a novel glycoside hydrolase family 18 N-acetylglucosaminidase from Paenibacillus barengoltzii To Be Published 0 0 0 0 6ITY 31709791 CTX-M-64 sulbactam complex 2018-11-26 2019-10-30 Cheng, Q.,Xu, C.,Chai, J.,Zhang, R.,Wai Chi Chan, E.,Chen, S. Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution. Acs Infect Dis. 2020 6 577 587 6J09 31702961 Crystal structure of Haemophilus Influenzae BamA POTRA1-4 2018-12-21 2019-10-30 Ma, X.,Wang, Q.,Li, Y.,Tan, P.,Wu, H.,Wang, P.,Dong, X.,Hong, L.,Meng, G. How BamA recruits OMP substratesviapoly-POTRAs domain. Faseb J. 2019 33 14690 14702 6J25 31709791 CTX-M-64 beta-lactamase mutant-S130T 2018-12-30 2019-10-30 Cheng, Q.,Xu, C.,Chai, J.,Zhang, R.,Wai Chi Chan, E.,Chen, S. Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution. Acs Infect Dis. 2020 6 577 587 6J2B 31709791 CTX-M-64 beta-lactamase S130T sulbactam complex 2018-12-31 2019-10-30 Cheng, Q.,Xu, C.,Chai, J.,Zhang, R.,Wai Chi Chan, E.,Chen, S. Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution. Acs Infect Dis. 2020 6 577 587 6J2K 31709791 CTX-M-64 beta-lactamase S130T clavulanic acid complex 2019-01-01 2019-10-30 Cheng, Q.,Xu, C.,Chai, J.,Zhang, R.,Wai Chi Chan, E.,Chen, S. Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution. Acs Infect Dis. 2020 6 577 587 6J2O 31709791 Crystal structure of CTX-M-64 clavulanic acid complex 2019-01-02 2019-10-30 Cheng, Q.,Xu, C.,Chai, J.,Zhang, R.,Wai Chi Chan, E.,Chen, S. Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution. Acs Infect Dis. 2020 6 577 587 6JJP 31667366 Crystal structure of Fab of a PD-1 monoclonal antibody MW11-h317 in complex with PD-1 2019-02-26 2019-10-30 Wang, M.,Wang, J.,Wang, R.,Jiao, S.,Wang, S.,Zhang, J.,Zhang, M. Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation. Commun Biol 2019 2 392 392 6R46 31645759 Crystal structure of LPOR (Thermosynechococcus elongatus) complexed with NADP+ at 2.5A resolution 2019-03-22 2019-10-30 Zhang, S.,Heyes, D.J.,Feng, L.,Sun, W.,Johannissen, L.O.,Liu, H.,Levy, C.W.,Li, X.,Yang, J.,Yu, X.,Lin, M.,Hardman, S.J.O.,Hoeven, R.,Sakuma, M.,Hay, S.,Leys, D.,Rao, Z.,Zhou, A.,Cheng, Q.,Scrutton, N.S. Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature 2019 574 722 725 6IUP 31335138 Crystal structure of FGFR4 kinase domain in complex with compound 5 2018-11-29 2019-11-06 Wang, Y.,Dai, Y.,Wu, X.,Li, F.,Liu, B.,Li, C.,Liu, Q.,Zhou, Y.,Wang, B.,Zhu, M.,Cui, R.,Tan, X.,Xiong, Z.,Liu, J.,Tan, M.,Xu, Y.,Geng, M.,Jiang, H.,Liu, H.,Ai, J.,Zheng, M. Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. J.Med.Chem. 2019 62 7473 7488 6J0D 31278262 Crystal structure of OsSUF4 2018-12-24 2019-11-06 Liu, B.,Liu, Y.,Wang, B.,Luo, Q.,Shi, J.,Gan, J.,Shen, W.H.,Yu, Y.,Dong, A. The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment. Nat Commun 2019 10 2999 2999 6J14 30952089 Complex structure of GY-14 and PD-1 2018-12-27 2019-11-06 Chen, D.,Tan, S.,Zhang, H.,Wang, H.,He, W.,Shi, R.,Tong, Z.,Zhu, J.,Cheng, H.,Gao, S.,Chai, Y.,Qi, J.,Xiao, M.,Yan, J.,Gao, G.F. The FG Loop of PD-1 Serves as a ""Hotspot"" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. Iscience 2019 14 113 124 6J15 30952089 Complex structure of GY-5 Fab and PD-1 2018-12-27 2019-11-06 Chen, D.,Tan, S.,Zhang, H.,Wang, H.,He, W.,Shi, R.,Tong, Z.,Zhu, J.,Cheng, H.,Gao, S.,Chai, Y.,Qi, J.,Xiao, M.,Yan, J.,Gao, G.F. The FG Loop of PD-1 Serves as a ""Hotspot"" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. Iscience 2019 14 113 124 6JFU 31668930 Crystal structure of Nme2Cas9 in complex with sgRNA and target DNA (AGGCCC PAM) 2019-02-12 2019-11-06 Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell 2019 76 938 0 6K6R Crystal structure of Saccharomyces cerevisiae single domain sulfurtranferase RDL2 2019-06-04 2019-11-06 Wang, Q.D.,Li, H.,Xia, Y.,Xun, L.,Li, H.J. Saccharomyces cerevisiaeRhodanese RDL2 Uses the ArgResidue of the Active-Site Loop for Thiosulfate Decomposition Antioxidants 2021 10 0 0 6KC7 31668930 Crystal structure of Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in seed-base paring state 2019-06-27 2019-11-06 Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell 2019 76 938 0 6KC8 31668930 Crystal structure of WT Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in post-cleavage state 2019-06-27 2019-11-06 Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell 2019 76 938 0 6KZY 35359603 Cu(II) loaded Tegillarca granosa ferritin 2019-09-25 2019-11-06 Ming, T.H.,Jiang, Q.Q.,Huo, C.,Huan, H.S.,Wu, Y.,Su, C.,Qiu, X.,Lu, C.,Zhou, J.,Li, Y.,Han, J.,Zhang, Z.,Su, X.R. Structural Insights Into the Effects of Interactions With Iron and Copper Ions on Ferritin From the Blood Clam Tegillarca granosa. Front Mol Biosci 2022 9 800008 800008 6L55 35359603 Recombinant Tegillarca granosa ferritin 2019-10-22 2019-11-06 Ming, T.H.,Jiang, Q.Q.,Huo, C.,Huan, H.S.,Wu, Y.,Su, C.,Qiu, X.,Lu, C.,Zhou, J.,Li, Y.,Han, J.,Zhang, Z.,Su, X.R. Structural Insights Into the Effects of Interactions With Iron and Copper Ions on Ferritin From the Blood Clam Tegillarca granosa. Front Mol Biosci 2022 9 800008 800008 6L58 35359603 Cu(II) loaded Tegillarca granosa M-ferritin soaked with Fe(II) 2019-10-22 2019-11-06 Ming, T.H.,Jiang, Q.Q.,Huo, C.,Huan, H.S.,Wu, Y.,Su, C.,Qiu, X.,Lu, C.,Zhou, J.,Li, Y.,Han, J.,Zhang, Z.,Su, X.R. Structural Insights Into the Effects of Interactions With Iron and Copper Ions on Ferritin From the Blood Clam Tegillarca granosa. Front Mol Biosci 2022 9 800008 800008 6IR1 34562299 Crystal structure of red fluorescent protein mCherry complexed with the nanobody LaM4 at 1.9 Angstron resolution 2018-11-09 2019-11-13 Wang, Z.,Li, L.,Hu, R.,Zhong, P.,Zhang, Y.,Cheng, S.,Jiang, H.,Liu, R.,Ding, Y. Structural insights into the binding of nanobodies LaM2 and LaM4 to the red fluorescent protein mCherry. Protein Sci. 2021 30 2298 2309 6IR5 31711377 P domain of GII.3-TV24 2018-11-10 2019-11-13 Yang, Y.,Xia, M.,Wang, L.,Arumugam, S.,Wang, Y.,Ou, X.,Wang, C.,Jiang, X.,Tan, M.,Chen, Y.,Li, X. Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses. Emerg Microbes Infect 2019 8 1642 1657 6JFL 31664033 Nucleotide-free Mitofusin2 (MFN2) 2019-02-10 2019-11-13 Li, Y.J.,Cao, Y.L.,Feng, J.X.,Qi, Y.,Meng, S.,Yang, J.F.,Zhong, Y.T.,Kang, S.,Chen, X.,Lan, L.,Luo, L.,Yu, B.,Chen, S.,Chan, D.C.,Hu, J.,Gao, S. Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun 2019 10 4914 4914 6JFM 31664033 Mitofusin2 (MFN2)_T111D 2019-02-10 2019-11-13 Li, Y.J.,Cao, Y.L.,Feng, J.X.,Qi, Y.,Meng, S.,Yang, J.F.,Zhong, Y.T.,Kang, S.,Chen, X.,Lan, L.,Luo, L.,Yu, B.,Chen, S.,Chan, D.C.,Hu, J.,Gao, S. Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun 2019 10 4914 4914 6KJU 31606206 Huge conformation shift of Vibrio cholerae VqmA dimer in the absence of target DNA provides insight into DNA-binding mechanisms of LuxR-type receptors 2019-07-23 2019-11-13 Wu, H.,Li, M.,Peng, C.,Yin, Y.,Guo, H.,Wang, W.,Xu, Q.,Zhou, H.,Xu, C.,Yu, F.,He, J. Large conformation shifts of Vibrio cholerae VqmA dimer in the absence of target DNA provide insight into DNA-binding mechanisms of LuxR-type receptors. Biochem.Biophys.Res.Commun. 2019 520 399 405 6KKS 31733060 Structural insights into target DNA recognition by R2R3-type MYB transcription factor 2019-07-27 2019-11-13 Wang, B.,Luo, Q.,Li, Y.,Yin, L.,Zhou, N.,Li, X.,Gan, J.,Dong, A. Structural insights into target DNA recognition by R2R3-MYB transcription factors. Nucleic Acids Res. 2020 48 460 471 6KNH 31634470 Crystal structure of SbnH in complex with citrate, a PLP-dependent decarboxylase in Staphyloferrin B biothesynthesis 2019-08-05 2019-11-13 Tang, J.,Ju, Y.,Gu, Q.,Xu, J.,Zhou, H. Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis. J.Mol.Biol. 2019 431 4868 4881 6KNI 31634470 Crystal structure of SbnH in complex with the cofactor PLP, a PLP-dependent decarboxylase in Staphyloferrin B biothesynthesis 2019-08-05 2019-11-13 Tang, J.,Ju, Y.,Gu, Q.,Xu, J.,Zhou, H. Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis. J.Mol.Biol. 2019 431 4868 4881 6L56 35359603 Fe(II) loaded Tegillarca granosa ferritin 2019-10-22 2019-11-13 Ming, T.H.,Jiang, Q.Q.,Huo, C.,Huan, H.S.,Wu, Y.,Su, C.,Qiu, X.,Lu, C.,Zhou, J.,Li, Y.,Han, J.,Zhang, Z.,Su, X.R. Structural Insights Into the Effects of Interactions With Iron and Copper Ions on Ferritin From the Blood Clam Tegillarca granosa. Front Mol Biosci 2022 9 800008 800008 6IST 32176738 Crystal structure of a wild type endolysin LysIME-EF1 2018-11-19 2019-11-20 Zhou, B.,Zhen, X.,Zhou, H.,Zhao, F.,Fan, C.,Perculija, V.,Tong, Y.,Mi, Z.,Ouyang, S. Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage. Plos Pathog. 2020 16 0 0 6J0Q 31711377 Crystal structure of P domain from GII.11 swine norovirus 2018-12-25 2019-11-20 Yang, Y.,Xia, M.,Wang, L.,Arumugam, S.,Wang, Y.,Ou, X.,Wang, C.,Jiang, X.,Tan, M.,Chen, Y.,Li, X. Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses. Emerg Microbes Infect 2019 8 1642 1657 6K0J 31754034 The co-crystal structure of DYRK2 with a small molecule inhibitor 2019-05-06 2019-11-20 Banerjee, S.,Wei, T.,Wang, J.,Lee, J.J.,Gutierrez, H.L.,Chapman, O.,Wiley, S.E.,Mayfield, J.E.,Tandon, V.,Juarez, E.F.,Chavez, L.,Liang, R.,Sah, R.L.,Costello, C.,Mesirov, J.P.,de la Vega, L.,Cooper, K.L.,Dixon, J.E.,Xiao, J.,Lei, X. Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression. Proc.Natl.Acad.Sci.USA 2019 116 24881 24891 6ICW 31747596 Crystal structure of H7 hemagglutinin mutant AH-SGTQ (A138S, V186G, P221T and L226Q) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-07 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ICX 31747596 Crystal structure of H7 hemagglutinin mutant AH-AGPL (V186G) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-07 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ICY 31747596 Crystal structure of H7 hemagglutinin mutant H7-AGTL ( V186G, P221T) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-07 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ID2 31747596 Crystal structure of H7 hemagglutinin mutant H7-AVTL (P221T) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-08 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ID3 31747596 Crystal structure of H7 hemagglutinin mutant H7-SGPL ( A138S, V186G) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-08 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ID5 31747596 Crystal structure of H7 hemagglutinin mutant H7-SVPL ( A138S) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-08 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ID8 31747596 Crystal structure of H7 hemagglutinin mutant H7-SVTL ( A138S, P221T) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-09 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ID9 31747596 Crystal structure of H7 hemagglutinin mutant H7-SGTL ( A138S, V186G, P221T) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-09 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6IDA 31747596 Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) from the influenza virus A/Anhui/1/2013 (H7N9) 2018-09-09 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6IDD 31747596 Crystal structure of H7 hemagglutinin mutant SH1-AVPL ( S138A, G186V, T221P, Q226L) from the influenza virus A/Shanghai/1/2013 (H7N9) 2018-09-09 2019-11-27 Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep 2019 29 2217 0 6ITM 32050066 Crystal structure of FXR in complex with agonist XJ034 2018-11-23 2019-11-27 Xia, J.,Wang, Z.,Huan, Y.,Xue, W.,Wang, X.,Wang, Y.,Liu, Z.,Hsieh, J.H.,Zhang, L.,Wu, S.,Shen, Z.,Zhang, H.,Wang, X.S. Pose Filter-Based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists. J.Chem.Inf.Model. 2020 60 1202 1214 6IZO 31725950 Crystal structure of DNA polymerase sliding clamp from Caulobacter crescentus 2018-12-20 2019-11-27 Jiang, X.,Zhang, L.,An, J.,Wang, M.,Teng, M.,Guo, Q.,Li, X. Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication. Febs J. 2020 287 2292 2311 6JH7 31726097 Crystal structure of AerF from Microcystis aeruginosa 2019-02-17 2019-11-27 Qiu, X.,Wei, Y.,Zhu, W.,Fu, J.,Duan, X.,Jin, H.,Zhu, P.,Zhou, C.,Yan, X. Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin J.Struct.Biol. 2019 0 0 0 6JHA 31726097 Crystal structure of NADPH bound AerF from Microcystis aeruginosa 2019-02-17 2019-11-27 Qiu, X.,Wei, Y.,Zhu, W.,Fu, J.,Duan, X.,Jin, H.,Zhu, P.,Zhou, C.,Yan, X. Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin J.Struct.Biol. 2019 0 0 0 6JHB 31726097 Crystal structure of NADPH and 4-hydroxyphenylpyruvic acid bound AerF from Microcystis aeruginosa 2019-02-17 2019-11-27 Qiu, X.,Wei, Y.,Zhu, W.,Fu, J.,Duan, X.,Jin, H.,Zhu, P.,Zhou, C.,Yan, X. Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin J.Struct.Biol. 2019 0 0 0 6JIR 31725950 Crystal structure of C. crescentus beta sliding clamp with PEG bound to putative beta-motif tethering region 2019-02-23 2019-11-27 Jiang, X.,Zhang, L.,An, J.,Wang, M.,Teng, M.,Guo, Q.,Li, X. Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication. Febs J. 2020 287 2292 2311 6L6H 31706575 Crystal structure of Lpg0189 2019-10-29 2019-11-27 Chen, X.,Liu, S.,Jiang, S.,Zhang, X.,Zhang, N.,Ma, J.,Ge, H. Crystal structure of a hypothetical T2SS effector Lpg0189 from Legionella pneumophila reveals a novel protein fold. Biochem.Biophys.Res.Commun. 2020 521 799 805 6N5V Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine 2018-11-22 2019-11-27 Cai, Y.,Shao, N.,Xie, H.,Futamura, Y.,Panjikar, S.,Liu, H.,Zhu, H.,Osada, H.,Zou, H. Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine to be published 0 0 0 0 6IUL Crystal structure of Lamprey immune protein 2018-11-29 2019-12-04 Li, Q.W.,Pang, Y. Structure of a pore-forming protein To Be Published 0 0 0 0 6IUR 32589942 A phosphatase complex STRN3-PP2Aa 2018-11-30 2019-12-04 Tang, Y.,Fang, G.,Guo, F.,Zhang, H.,Chen, X.,An, L.,Chen, M.,Zhou, L.,Wang, W.,Ye, T.,Zhou, L.,Nie, P.,Yu, H.,Lin, M.,Zhao, Y.,Lin, X.,Yuan, Z.,Jiao, S.,Zhou, Z. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell 2020 38 115 0 6IUX Crystal structure of a hydrolase protein 2018-12-01 2019-12-04 Liu, X.H.,Yu, X.C. Crystal structure of protein To Be Published 0 0 0 0 6JAK 31455720 OtsA apo structure 2019-01-24 2019-12-04 Wang, S.,Zhao, Y.,Yi, L.,Shen, M.,Wang, C.,Zhang, X.,Yang, J.,Peng, Y.L.,Wang, D.,Liu, J. Crystal structures of Magnaporthe oryzae trehalose-6-phosphate synthase (MoTps1) suggest a model for catalytic process of Tps1. Biochem.J. 2019 476 3227 3240 6JBI 31455720 Structure of Tps1 apo structure 2019-01-25 2019-12-04 Wang, S.,Zhao, Y.,Yi, L.,Shen, M.,Wang, C.,Zhang, X.,Yang, J.,Peng, Y.L.,Wang, D.,Liu, J. Crystal structures of Magnaporthe oryzae trehalose-6-phosphate synthase (MoTps1) suggest a model for catalytic process of Tps1. Biochem.J. 2019 476 3227 3240 6JOX 31668066 triosephosphate isomerase-scylla paramamosain 2019-03-25 2019-12-04 Xia, F.,Li, M.S.,Liu, Q.M.,Liu, M.,Yang, Y.,Cao, M.J.,Chen, G.X.,Jin, T.,Liu, G.M. Crystal Structure Analysis and Conformational Epitope Mutation of Triosephosphate Isomerase, a Mud Crab Allergen. J.Agric.Food Chem. 2019 67 12918 12926 6KRY 31775346 Structure of staphylococcal enterotoxin SEN 2019-08-22 2019-12-04 Zeng, C.,Liu, Z.,Han, Z. Structure of Staphylococcal Enterotoxin N: Implications for Binding Properties to Its Cellular Proteins. Int J Mol Sci 2019 20 0 0 6KYK 31879129 Crystal structure of Shank3 NTD-ANK mutant in complex with Rap1 2019-09-19 2019-12-04 Cai, Q.,Hosokawa, T.,Zeng, M.,Hayashi, Y.,Zhang, M. Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. Structure 2020 28 290 0 6L8Q 31776269 Complex structure of bat CD26 and MERS-RBD 2019-11-07 2019-12-04 Yuan, Y.,Qi, J.,Peng, R.,Li, C.,Lu, G.,Yan, J.,Wang, Q.,Gao, G.F. Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species. J.Virol. 2020 94 0 0 6IWF 31475514 Crystal structure of HitA from Pseudomonas aeruginosa 2018-12-05 2019-12-11 Guo, Y.,Li, W.,Li, H.,Xia, W. Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa. Acs Infect Dis. 2019 5 1693 1697 6IWK 31751711 The Structure of Maltooligosaccharide-forming Amylase from Pseudomonas saccharophila STB07 2018-12-05 2019-12-11 Zhang, Z.,Jin, T.,Xie, X.,Ban, X.,Li, C.,Hong, Y.,Cheng, L.,Gu, Z.,Li, Z. Structure of maltotetraose-forming amylase from Pseudomonas saccharophila STB07 provides insights into its product specificity. Int.J.Biol.Macromol. 2020 154 1303 1313 6JQF 31345574 Crystallization analysis of a beta-N-acetylhexosaminidase (Am2136) from Akkermansia muciniphila 2019-03-31 2019-12-11 Chen, X.,Li, M.,Wang, Y.,Tang, R.,Zhang, M. Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a beta-N-acetylhexosaminidase in Akkermansia muciniphila. Biochem.Biophys.Res.Commun. 2019 517 29 35 6K0Y 31780710 Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor 2019-05-08 2019-12-11 Liu, J.,Wang, G.,Liu, L.,Wu, R.,Wu, Y.,Fang, C.,Zhou, X.,Jiao, J.,Gu, Y.,Zhou, H.,Xie, Z.,Sun, Z.,Chen, D.,Dai, K.,Wang, D.,Tang, W.,Yang, T.T.C. Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor. Sci Rep 2019 9 17830 17830 6KWQ 31863580 Crystal structure of enterovirus 71 polymerase elongation complex (native form) 2019-09-08 2019-12-11 Shi, W.,Ye, H.Q.,Deng, C.L.,Li, R.,Zhang, B.,Gong, P. A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res. 2020 48 1392 1405 6KWR 31863580 Crystal structure of enterovirus 71 polymerase elongation complex (ddCTP form) 2019-09-08 2019-12-11 Shi, W.,Ye, H.Q.,Deng, C.L.,Li, R.,Zhang, B.,Gong, P. A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res. 2020 48 1392 1405 6L3G 31772234 Structural Basis for DNA Unwinding at Forked dsDNA by two coordinating Pif1 helicases 2019-10-10 2019-12-11 Su, N.,Byrd, A.K.,Bharath, S.R.,Yang, O.,Jia, Y.,Tang, X.,Ha, T.,Raney, K.D.,Song, H. Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases. Nat Commun 2019 10 5375 5375 6L9F Crystal structure of TEAD4 in complex with a novel FAM181A peptide 2019-11-09 2019-12-11 Chen, M.,Zhou, Z. Crystal structure of TEAD4 in complex with a novel FAM181A peptide To be published 0 0 0 0 6IXL 33957092 Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri 2018-12-11 2019-12-18 Tang, W.,Wu, M.,Qin, N.,Liu, L.,Meng, R.,Wang, C.,Wang, P.,Zang, J.,Zhu, G. Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys. 2021 708 108898 108898 6IXN 33957092 Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and citrate 2018-12-11 2019-12-18 Tang, W.,Wu, M.,Qin, N.,Liu, L.,Meng, R.,Wang, C.,Wang, P.,Zang, J.,Zhu, G. Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys. 2021 708 108898 108898 6IXT 33957092 Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and Mg2+ 2018-12-12 2019-12-18 Tang, W.,Wu, M.,Qin, N.,Liu, L.,Meng, R.,Wang, C.,Wang, P.,Zang, J.,Zhu, G. Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys. 2021 708 108898 108898 6IXX Crystal structure of a complex between psychrophilic marine protease MP and its inhibitor LupI 2018-12-12 2019-12-18 Hao, J.H. Crystal structure of a complex between psychrophilic marine protease MP and its inhibitor LupI To be published 0 0 0 0 6IY4 Crystal structure of a psychrophilic marine protease MP inhibitor 2018-12-12 2019-12-18 Hao, J.H. Crystal structure of a psychrophilic marine protease MP inhibitor To be published 0 0 0 0 6JKY 31825121 Crystal structure of MvcA-UBE2N-Ub complex from Legionella pneumophila 2019-03-03 2019-12-18 Gan, N.,Guan, H.,Huang, Y.,Yu, T.,Fu, J.,Nakayasu, E.S.,Puvar, K.,Das, C.,Wang, D.,Ouyang, S.,Luo, Z.Q. Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination. Embo J. 2020 39 0 0 6K11 31825121 Crystal structure of MvcA from Legionella pneumophila 2019-05-09 2019-12-18 Gan, N.,Guan, H.,Huang, Y.,Yu, T.,Fu, J.,Nakayasu, E.S.,Puvar, K.,Das, C.,Wang, D.,Ouyang, S.,Luo, Z.Q. Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination. Embo J. 2020 39 0 0 6K11 31825121 Crystal structure of MvcA from Legionella pneumophila 2019-05-09 2019-12-18 Gan, N.,Guan, H.,Huang, Y.,Yu, T.,Fu, J.,Nakayasu, E.S.,Puvar, K.,Das, C.,Wang, D.,Ouyang, S.,Luo, Z.Q. Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination. Embo J. 2020 39 0 0 6KE1 31792780 Crystal structure of TtCas1 2019-07-03 2019-12-18 Yang, J.,Li, J.,Wang, J.,Sheng, G.,Wang, M.,Zhao, H.,Yang, Y.,Wang, Y. Crystal structure of Cas1 in complex with branched DNA. Sci China Life Sci 2020 63 516 528 6KHR 31894729 Structure of glycinamide-RNase-transformylase T from Mycobacterium tuberculosis 2019-07-16 2019-12-18 Chen, C.,Liu, Z.,Liu, L.,Wang, J.,Jin, Q. Structural characterization of glycinamide-RNase-transformylase T fromMycobacterium tuberculosis. Emerg Microbes Infect 2020 9 58 66 6LC1 31822342 Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter 2019-11-16 2019-12-18 Jiang, L.,Wei, H.,Yan, N.,Dai, S.,Li, J.,Qu, L.,Chen, X.,Guo, M.,Chen, Z.,Chen, Y. Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter. Biochem.Biophys.Res.Commun. 2020 523 1 5 6IZQ 31117515 PRMT4 bound with a bicyclic compound 2018-12-20 2019-12-25 Guo, Z.,Zhang, Z.,Yang, H.,Cao, D.,Xu, X.,Zheng, X.,Chen, D.,Wang, Q.,Li, Y.,Li, J.,Du, Z.,Wang, X.,Chen, L.,Ding, J.,Shen, J.,Geng, M.,Huang, X.,Xiong, B. Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia. J.Med.Chem. 2019 62 5414 5433 6J62 Crystal structure of mISG15/NS1B complex 2019-01-12 2019-12-25 Jiang, Y.N.,Wang, X.Q. Crystal structure of mISG15/NS1B complex To Be Published 0 0 0 0 6K6U 31472957 Crystal structure of the human YTHDC2 YTH domain 2019-06-04 2019-12-25 Ma, C.,Liao, S.,Zhu, Z. Crystal structure of human YTHDC2 YTH domain. Biochem.Biophys.Res.Commun. 2019 518 678 684 6KVM 32034060 Crystal structure of Chicken MHC Class II for 1.9 angstrom 2019-09-04 2019-12-25 Zhang, L.,Li, X.,Ma, L.,Zhang, B.,Meng, G.,Xia, C. A Newly Recognized Pairing Mechanism of the alpha- and beta-Chains of the Chicken Peptide-MHC Class II Complex. J Immunol. 2020 204 1630 1640 6J0T The crystal structure of exoinulinase INU1 2018-12-26 2020-01-01 Li, L.,Su, X. The Crystal Structure Study of Exoinulinase INU1 To Be Published 0 0 0 0 6J1U 33627391 influenza virus nucleoprotein with a specific inhibitor 2018-12-29 2020-01-01 Yang, F.,Pang, B.,Lai, K.K.,Cheung, N.N.,Dai, J.,Zhang, W.,Zhang, J.,Chan, K.H.,Chen, H.,Sze, K.H.,Zhang, H.,Hao, Q.,Yang, D.,Yuen, K.Y.,Kao, R.Y. Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle. J.Virol. 2021 95 0 0 6J22 31235255 Crystal structure of Bi-functional enzyme 2018-12-30 2020-01-01 Wang, Y.,Zhang, F.,Nie, Y.,Shang, G.,Zhang, H. Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochem.Biophys.Res.Commun. 2019 516 540 545 6J2L 31235255 Crystal structure of Bi-functional enzyme 2019-01-01 2020-01-01 Wang, Y.,Zhang, F.,Nie, Y.,Shang, G.,Zhang, H. Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochem.Biophys.Res.Commun. 2019 516 540 545 6J2S 31475514 Structure of HitA bound to gallium from Pseudomonas aeruginosa 2019-01-02 2020-01-01 Guo, Y.,Li, W.,Li, H.,Xia, W. Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa. Acs Infect Dis. 2019 5 1693 1697 6JVX 31860021 Crystal structure of RBM38 in complex with RNA 2019-04-17 2020-01-01 Qian, K.,Li, M.,Wang, J.,Zhang, M.,Wang, M. Structural basis for mRNA recognition by human RBM38. Biochem.J. 2020 477 161 172 6JVY 31860021 Crystal structure of RBM38 in complex with single-stranded DNA 2019-04-17 2020-01-01 Qian, K.,Li, M.,Wang, J.,Zhang, M.,Wang, M. Structural basis for mRNA recognition by human RBM38. Biochem.J. 2020 477 161 172 6L30 31888991 Crystal structure of the epithelial cell transforming 2 (ECT2) 2019-10-07 2020-01-01 Chen, M.,Pan, H.,Sun, L.,Shi, P.,Zhang, Y.,Li, L.,Huang, Y.,Chen, J.,Jiang, P.,Fang, X.,Wu, C.,Chen, Z. Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA 2020 117 1027 1035 6LAZ 31844059 the wildtype SAM-VI riboswitch bound to a N-mustard SAM analog M1 2019-11-13 2020-01-01 Sun, A.,Gasser, C.,Li, F.,Chen, H.,Mair, S.,Krasheninina, O.,Micura, R.,Ren, A. SAM-VI riboswitch structure and signature for ligand discrimination. Nat Commun 2019 10 5728 5728 6ION The complex of C4.4A with its antibody 11H10 Fab fragment 2018-10-30 2020-01-15 Jiang, Y.B.,Lin, L.,Chen, S.,Jiang, L.G.,Kriegbaum, M.C.,Gardsvoll, H.,Hansen, L.V.,Li, J.,Ploug, M.,Yuan, C.,Huang, M.D. Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/alpha-neurotoxin Domain Int J Biol Sci 2020 16 981 993 6IPB 31837310 Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15 2018-11-02 2020-01-15 Zhang, L.,Zhu, L.,Qu, W.,Wu, F.,Hu, M.,Xie, W.,Liu, Z.,Wang, C. Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem. Pharmacol. 2019 172 113753 113753 6J32 31160959 Crystal Structure Analysis of the Glycotransferase of kitacinnamycin 2019-01-03 2020-01-15 Shi, J.,Liu, C.L.,Zhang, B.,Guo, W.J.,Zhu, J.,Chang, C.Y.,Zhao, E.J.,Jiao, R.H.,Tan, R.X.,Ge, H.M. Genome mining and biosynthesis of kitacinnamycins as a STING activator. Chem Sci 2019 10 4839 4846 6J3N RORgammat LBD complexed with Ursonic Acid and SRC2.2 2019-01-05 2020-01-15 Liu, Z.H.,Huang, J.,Tang, Y. Structure of human RORgammat LBD with SCR2.2 at 1.99 Angstroms resolution To Be Published 0 0 0 0 6J3X The Structure of Maltooligosaccharide-forming Amylase from Pseudomonas saccharophila STB07 with Maltotriose 2019-01-06 2020-01-15 Zhang, Z.Q.,Ban, X.F.,Li, Z.F.,Jin, T.C.,Li, Y.L.,Gu, Z.B.,Li, C.M.,Shang, Y.H. Maltotetraose-forming amylase from Pseudomonas saccharophila STB07 To Be Published 0 0 0 0 6J5E Crystal structure of HIV-1 fusion inhibitor SC29EK complexed with gp41 NHR (N44) 2019-01-10 2020-01-15 Liu, Z.X.,Geng, X.Z.,Qin, B.,Cui, S. Crystal structure of HIV-1 fusion inhibitor SC29EK complexed with gp41 NHR (N44) To Be Published 0 0 0 0 6J6A Crystal structure of TldE from Thermococcus kodakarensis 2019-01-14 2020-01-15 Zhang, X.,Liu, J. Crystal structure of TldE from Thermococcus kodakarensis To Be Published 0 0 0 0 6JUY 31914412 Crystal Structure of ArgZ, apo structure, an Arginine Dihydrolase from the Ornithine-Ammonia Cycle in Cyanobacteria 2019-04-15 2020-01-15 Zhuang, N.,Zhang, H.,Li, L.,Wu, X.,Yang, C.,Zhang, Y. Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a ""bond rotation"" catalytic mechanism. J.Biol.Chem. 2020 295 2113 2124 6JUZ 31914412 Crystal Structure of N-terminal domain of ArgZ(N71S) covalently bond to a reaction intermediate 2019-04-15 2020-01-15 Zhuang, N.,Zhang, H.,Li, L.,Wu, X.,Yang, C.,Zhang, Y. Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a ""bond rotation"" catalytic mechanism. J.Biol.Chem. 2020 295 2113 2124 6KOB 31888984 X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis 2019-08-09 2020-01-15 Xu, J.,Ding, Z.,Liu, B.,Yi, S.M.,Li, J.,Zhang, Z.,Liu, Y.,Li, J.,Liu, L.,Zhou, A.,Gennis, R.B.,Zhu, J. Structure of the cytochromeaa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site. Proc.Natl.Acad.Sci.USA 2020 117 872 876 6KOC 31888984 X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis complexed with 3-iodo-N-oxo-2-heptyl-4-hydroxyquinoline 2019-08-09 2020-01-15 Xu, J.,Ding, Z.,Liu, B.,Yi, S.M.,Li, J.,Zhang, Z.,Liu, Y.,Li, J.,Liu, L.,Zhou, A.,Gennis, R.B.,Zhu, J. Structure of the cytochromeaa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site. Proc.Natl.Acad.Sci.USA 2020 117 872 876 6KOE 31888984 X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis 2019-08-09 2020-01-15 Xu, J.,Ding, Z.,Liu, B.,Yi, S.M.,Li, J.,Zhang, Z.,Liu, Y.,Li, J.,Liu, L.,Zhou, A.,Gennis, R.B.,Zhu, J. Structure of the cytochromeaa3-600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site. Proc.Natl.Acad.Sci.USA 2020 117 872 876 6KS5 31907282 Crystal structure of Legionella pneumophila deubiquitinase Ceg23 2019-08-23 2020-01-15 Ma, K.,Zhen, X.,Zhou, B.,Gan, N.,Cao, Y.,Fan, C.,Ouyang, S.,Luo, Z.Q.,Qiu, J. The bacterial deubiquitinase Ceg23 regulates the association of Lys-63-linked polyubiquitin molecules on theLegionellaphagosome. J.Biol.Chem. 2020 295 1646 1657 6L8D 31891428 Hexameric structure of the ATPase subunit of magnesium chelatase 2019-11-05 2020-01-15 Gao, Y.S.,Wang, Y.L.,Wang, X.,Liu, L. Hexameric structure of the ATPase motor subunit of magnesium chelatase in chlorophyll biosynthesis. Protein Sci. 2020 29 1040 1046 6IMA 32051560 Crystal Structure of ALKBH1 without alpha-1 (N37-C369) 2018-10-22 2020-01-22 Zhang, M.,Yang, S.,Nelakanti, R.,Zhao, W.,Liu, G.,Li, Z.,Liu, X.,Wu, T.,Xiao, A.,Li, H. Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA. Cell Res. 2020 30 197 210 6IMC 32051560 Crystal Structure of ALKBH1 in complex with Mn(II) and N-Oxalylglycine 2018-10-22 2020-01-22 Zhang, M.,Yang, S.,Nelakanti, R.,Zhao, W.,Liu, G.,Li, Z.,Liu, X.,Wu, T.,Xiao, A.,Li, H. Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA. Cell Res. 2020 30 197 210 6IZJ 31970556 Structural characterization of mutated NreA protein in nitrate binding site from Staphylococcus aureus 2018-12-19 2020-01-22 Sangare, L.,Chen, W.,Wang, C.,Chen, X.,Wu, M.,Zhang, X.,Zang, J. Structural insights into the conformational change of Staphylococcus aureus NreA at C-terminus. Biotechnol.Lett. 2020 42 787 795 6J94 32513704 Crystal structure of CYP97A3 2019-01-22 2020-01-22 Niu, G.,Guo, Q.,Wang, J.,Zhao, S.,He, Y.,Liu, L. Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA 2020 117 14150 14157 6J95 32513704 Crystal structure of CYP97A3 in complex with retinal 2019-01-22 2020-01-22 Niu, G.,Guo, Q.,Wang, J.,Zhao, S.,He, Y.,Liu, L. Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA 2020 117 14150 14157 6JJ3 31789032 BRD4 in complex with 138A 2019-02-25 2020-01-22 Jiang, F.,Hu, Q.,Zhang, Z.,Li, H.,Li, H.,Zhang, D.,Li, H.,Ma, Y.,Xu, J.,Chen, H.,Cui, Y.,Zhi, Y.,Zhang, Y.,Xu, J.,Zhu, J.,Lu, T.,Chen, Y. Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis. J.Med.Chem. 2019 62 11080 11107 6JJB 31789032 BRD4 in complex with ZZM1 2019-02-25 2020-01-22 Jiang, F.,Hu, Q.,Zhang, Z.,Li, H.,Li, H.,Zhang, D.,Li, H.,Ma, Y.,Xu, J.,Chen, H.,Cui, Y.,Zhi, Y.,Zhang, Y.,Xu, J.,Zhu, J.,Lu, T.,Chen, Y. Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis. J.Med.Chem. 2019 62 11080 11107 6JAS Human serum transferrin with iron citrate bound 2019-01-25 2020-01-29 Wang, M.,Wang, H.,Sun, H. Binding of ruthenium and osmium at non-iron sites of transferrin explains their iron-independent cellular uptake To Be Published 0 0 0 0 6JAT Crystal structure of SETD3 bound to Actin peptide and SFG 2019-01-25 2020-01-29 Li, H.,Zheng, Y. Crystal structure of SETD3 bound to Actin peptide and SFG to be published 0 0 0 0 6JBU High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3 Olfactomedin like domain 2019-01-26 2020-01-29 Liu, H.,Li, Z.,Xu, F. High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3 Olfactomedin like domain To Be Published 0 0 0 0 6JOH The crystal of nucleoside diphosphate kinase from Aspergillus flavus 2019-03-21 2020-01-29 Wang, Y.,Wang, S.H. Molecular and structural basis of Nucleoside Diphosphate Kinase regulating the spores and sclerotia development in Aspergillus flavus To Be Published 0 0 0 0 6KH1 31820500 Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes 2019-07-12 2020-01-29 Gu, C.,Chen, H.,Wang, Y.,Zhang, T.,Wang, H.,Zhao, G. Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry 2020 26 3016 3021 6KH3 31820500 Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes 2019-07-12 2020-01-29 Gu, C.,Chen, H.,Wang, Y.,Zhang, T.,Wang, H.,Zhao, G. Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry 2020 26 3016 3021 6KH4 31820500 Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes 2019-07-12 2020-01-29 Gu, C.,Chen, H.,Wang, Y.,Zhang, T.,Wang, H.,Zhao, G. Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry 2020 26 3016 3021 6KH5 31820500 Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes 2019-07-12 2020-01-29 Gu, C.,Chen, H.,Wang, Y.,Zhang, T.,Wang, H.,Zhao, G. Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes. Chemistry 2020 26 3016 3021 6JC9 32814814 Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with amino donor L-Gln 2019-01-28 2020-02-05 Xu, J.,Tang, X.,Zhu, Y.,Yu, Z.,Su, K.,Zhang, Y.,Dong, Y.,Zhu, W.,Zhang, C.,Wu, R.,Liu, J. Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Commun Biol 2020 3 455 455 6JCI Crystal structure of Prolyl Endopeptidase from Haliotis discus hannai with SUAM-14746 2019-01-28 2020-02-05 Li, W.,Cao, M. Crystal structure of Haliotis discus hannai Prolyl Endopeptidase To Be Published 0 0 0 0 6JDR 32075207 Crystal structure of methylated PRRSV nsp10 (helicase) 2019-02-02 2020-02-05 Tang, C.,Deng, Z.,Li, X.,Yang, M.,Tian, Z.,Chen, Z.,Wang, G.,Wu, W.,Feng, W.H.,Zhang, G.,Chen, Z. Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure. Viruses 2020 12 0 0 6JDS 32075207 Crystal structure of truncated PRRSV nsp10 (helicase) 2019-02-02 2020-02-05 Tang, C.,Deng, Z.,Li, X.,Yang, M.,Tian, Z.,Chen, Z.,Wang, G.,Wu, W.,Feng, W.H.,Zhang, G.,Chen, Z. Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure. Viruses 2020 12 0 0 6LU7 32272481 The crystal structure of COVID-19 main protease in complex with an inhibitor N3 2020-01-26 2020-02-05 Jin, Z.,Du, X.,Xu, Y.,Deng, Y.,Liu, M.,Zhao, Y.,Zhang, B.,Li, X.,Zhang, L.,Peng, C.,Duan, Y.,Yu, J.,Wang, L.,Yang, K.,Liu, F.,Jiang, R.,Yang, X.,You, T.,Liu, X.,Yang, X.,Bai, F.,Liu, H.,Liu, X.,Guddat, L.W.,Xu, W.,Xiao, G.,Qin, C.,Shi, Z.,Jiang, H.,Rao, Z.,Yang, H. Structure of Mprofrom SARS-CoV-2 and discovery of its inhibitors. Nature 2020 582 289 293 6JBS 31925310 Bifunctional xylosidase/glucosidase LXYL 2019-01-26 2020-02-12 Yang, L.Y.,Chen, T.J.,Wang, F.,Li, L.,Yu, W.B.,Si, Y.K.,Chen, J.J.,Liu, W.C.,Zhu, P.,Gong, W.M. Structures of beta-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Commun Biol 2020 3 22 22 6JD6 An ankyrin-repeat protein complex guides cargos from inner envelope to thylakoid Tat pathway 2019-01-31 2020-02-19 Ouyang, M.,Zhang, L.X. An ankyrin-repeat protein complex guides cargos from inner envelope to thylakoid Tat pathway To Be Published 0 0 0 0 6JSJ 32041880 Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1 2019-04-08 2020-02-19 Yan, L.,Qi, Y.,Ricketson, D.,Li, L.,Subramanian, K.,Zhao, J.,Yu, C.,Wu, L.,Sarsam, R.,Wong, M.,Lou, Z.,Rao, Z.,Nunnari, J.,Hu, J. Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1. Proc.Natl.Acad.Sci.USA 2020 117 4061 4070 6JUI 31652438 The atypical Myb-like protein Cdc5 contains two distinct nucleic acid-binding surfaces 2019-04-14 2020-02-19 Wang, C.,Li, M.,Li, G.,Liu, X.,Zhao, W.,Yu, B.,Liu, J.,Yang, J.,Peng, Y.L. Two distinct nucleic acid binding surfaces of Cdc5 regulate development. Biochem.J. 2019 476 3355 3368 6KHX 32027024 Crystal structure of Prx from Akkermansia muciniphila 2019-07-16 2020-02-19 Li, M.,Wang, J.,Xu, W.,Wang, Y.,Zhang, M.,Wang, M. Crystal structure of Akkermansia muciniphila peroxiredoxin reveals a novel regulatory mechanism of typical 2-Cys Prxs by a distinct loop. Febs Lett. 2020 594 1550 1563 6L00 32176738 Crystal structure of the cell-wall binding domain (CBD) of endolysin LysIME-EF1 2019-09-25 2020-02-19 Zhou, B.,Zhen, X.,Zhou, H.,Zhao, F.,Fan, C.,Perculija, V.,Tong, Y.,Mi, Z.,Ouyang, S. Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage. Plos Pathog. 2020 16 0 0 6LGX 32004500 Structure of Rabies virus glycoprotein at basic pH 2019-12-06 2020-02-19 Yang, F.,Lin, S.,Ye, F.,Yang, J.,Qi, J.,Chen, Z.,Lin, X.,Wang, J.,Yue, D.,Cheng, Y.,Chen, Z.,Chen, H.,You, Y.,Zhang, Z.,Yang, Y.,Yang, M.,Sun, H.,Li, Y.,Cao, Y.,Yang, S.,Wei, Y.,Gao, G.F.,Lu, G. Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody. Cell Host Microbe 2020 27 441 0 6XVD 32019421 Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition 2020-01-21 2020-02-19 Xue, G.,Xie, X.,Zhou, Y.,Yuan, C.,Huang, M.,Jiang, L. Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases. Biosci.Biotechnol.Biochem. 2020 84 1153 1159 6J9J 32699416 crystal structure of SESTD2 in complex with H3.3S31phK36M peptide 2019-01-23 2020-02-26 Armache, A.,Yang, S.,Martinez de Paz, A.,Robbins, L.E.,Durmaz, C.,Cheong, J.Q.,Ravishankar, A.,Daman, A.W.,Ahimovic, D.J.,Klevorn, T.,Yue, Y.,Arslan, T.,Lin, S.,Panchenko, T.,Hrit, J.,Wang, M.,Thudium, S.,Garcia, B.A.,Korb, E.,Armache, K.J.,Rothbart, S.B.,Hake, S.B.,Allis, C.D.,Li, H.,Josefowicz, S.Z. Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature 2020 583 852 857 6JI3 BRD4-BD1 bound with ligand 103 2019-02-20 2020-02-26 Cao, D.Y.,Li, Y.L.,Du, Z.Y.,Li, J.,Xiong, B. brd4-bd1 bound with ligand 103 To Be Published 0 0 0 0 6JI4 brd4-bd1 bound with ligand 138 2019-02-20 2020-02-26 Cao, D.Y.,Li, Y.L.,Du, Z.Y.,Li, J.,Xiong, B. brd4-bd1 bound with ligand 138 To Be Published 0 0 0 0 6JI5 brd4-bd1 bound with ligand 167 2019-02-20 2020-02-26 Cao, D.Y.,Li, Y.L.,Du, Z.Y.,Li, J.,Xiong, B. brd4-bd1 bound with ligand 167 To Be Published 0 0 0 0 6JJ5 BRD4 in complex with 259 2019-02-25 2020-02-26 Xu, J.,Zhu, J.,Chen, Y.,Jiang, F. BRD4 in complex with ZZM1 To Be Published 0 0 0 0 6JJ6 BRD4 in complex with 500 2019-02-25 2020-02-26 Xu, J.,Zhu, J.,Chen, Y.,Jiang, F. BRD4 in complex with ZZM1 To Be Published 0 0 0 0 6JJG Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex 2019-02-25 2020-02-26 Zhang, Y.S.,Parkinson, G.N.,Wagner, A.,Wei, D.G. Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex To Be Published 0 0 0 0 6KJ0 31925310 Bifunctional xylosidase/glucosidase LXYL mutant E529Q C2221 2019-07-20 2020-02-26 Yang, L.Y.,Chen, T.J.,Wang, F.,Li, L.,Yu, W.B.,Si, Y.K.,Chen, J.J.,Liu, W.C.,Zhu, P.,Gong, W.M. Structures of beta-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Commun Biol 2020 3 22 22 6KSQ 32058968 Middle Domain of Human HSP90 Alpha 2019-08-25 2020-02-26 Zhou, C.,Zhang, C.,Zhu, H.,Liu, Z.,Su, H.,Zhang, X.,Chen, T.,Zhong, Y.,Hu, H.,Xiong, M.,Zhou, H.,Xu, Y.,Zhang, A.,Zhang, N. Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone. Iscience 2020 23 100857 100857 6L8T 32171857 Crystal structure of the Fab fragment of a humanized HBV therapeutic antibody 2019-11-07 2020-02-26 Zhou, B.,Xia, L.,Zhang, T.,You, M.,Huang, Y.,He, M.,Su, R.,Tang, J.,Zhang, J.,Li, S.,An, Z.,Yuan, Q.,Luo, W.,Xia, N. Structure guided maturation of a novel humanized anti-HBV antibody and its preclinical development. Antiviral Res. 2020 180 104757 104757 6LFD Crystal structure of VMB-1 at pH5.5(Bis-Tris) 2019-12-02 2020-02-26 Chen, S.,Cheng, Q. Crystal structure of VMB-1 at pH 5.5(Bis-Tris) To Be Published 0 0 0 0 6LNW 32037091 Crystal structure of accessory secretory protein 1,2 and 3 in Streptococcus pneumoniae 2020-01-02 2020-02-26 Guo, C.,Feng, Z.,Zuo, G.,Jiang, Y.L.,Zhou, C.Z.,Chen, Y.,Hou, W.T. Structural and functional insights into the Asp1/2/3 complex mediated secretion of pneumococcal serine-rich repeat protein PsrP. Biochem.Biophys.Res.Commun. 2020 524 784 790 6L6W 32074393 The structure of ScoE with intermediate 2019-10-29 2020-03-04 Chen, T.Y.,Chen, J.,Tang, Y.,Zhou, J.,Guo, Y.,Chang, W.C. Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases. Angew.Chem.Int.Ed.Engl. 2020 59 7367 7371 6LYH 32193380 Crystal structure of tea N9-methyltransferase CkTcS in complex with SAH and 1,3,7-trimethyluric acid 2020-02-14 2020-03-04 Zhang, Y.H.,Li, Y.F.,Wang, Y.,Tan, L.,Cao, Z.Q.,Xie, C.,Xie, G.,Gong, H.B.,Sun, W.Y.,Ouyang, S.H.,Duan, W.J.,Lu, X.,Ding, K.,Kurihara, H.,Hu, D.,Zhang, Z.M.,Abe, I.,He, R.R. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nat Commun 2020 11 1473 1473 6LYI 32193380 Crystal structure of a N-methyltransferase CkTbS from Camellia assamica var. kucha 2020-02-14 2020-03-04 Zhang, Y.H.,Li, Y.F.,Wang, Y.,Tan, L.,Cao, Z.Q.,Xie, C.,Xie, G.,Gong, H.B.,Sun, W.Y.,Ouyang, S.H.,Duan, W.J.,Lu, X.,Ding, K.,Kurihara, H.,Hu, D.,Zhang, Z.M.,Abe, I.,He, R.R. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nat Commun 2020 11 1473 1473 6JX9 31525997 Structure of Y17107 complexed HPPD 2019-04-22 2020-03-11 He, B.,Dong, J.,Lin, H.Y.,Wang, M.Y.,Li, X.K.,Zheng, B.F.,Chen, Q.,Hao, G.F.,Yang, W.C.,Yang, G.F. Pyrazole-Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. J.Agric.Food Chem. 2019 67 10844 10852 6KN0 32109412 caspase-1 P20/P10 C285A in complex with human GSDMD-C domain 2019-08-02 2020-03-11 Wang, K.,Sun, Q.,Zhong, X.,Zeng, M.,Zeng, H.,Shi, X.,Li, Z.,Wang, Y.,Zhao, Q.,Shao, F.,Ding, J. Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell 2020 180 941 0 6KN1 32109412 P20/P12 of caspase-11 mutant C254A 2019-08-02 2020-03-11 Wang, K.,Sun, Q.,Zhong, X.,Zeng, M.,Zeng, H.,Shi, X.,Li, Z.,Wang, Y.,Zhao, Q.,Shao, F.,Ding, J. Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell 2020 180 941 0 6KOP 32127479 Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 9 nt 2019-08-12 2020-03-11 Li, L.,Molodtsov, V.,Lin, W.,Ebright, R.H.,Zhang, Y. RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA 2020 117 5801 5809 6IRL 32152225 Crystal structure of 8-mer peptide from avian influenza H5N1 virus in complex with BF2*1501 2018-11-13 2020-03-18 Li, X.,Zhang, L.,Liu, Y.,Ma, L.,Zhang, N.,Xia, C. Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope. J.Biol.Chem. 2020 295 5292 5306 6LZG 32275855 Structure of novel coronavirus spike receptor-binding domain complexed with its receptor ACE2 2020-02-19 2020-03-18 Wang, Q.,Zhang, Y.,Wu, L.,Niu, S.,Song, C.,Zhang, Z.,Lu, G.,Qiao, C.,Hu, Y.,Yuen, K.Y.,Wang, Q.,Zhou, H.,Yan, J.,Qi, J. Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. Cell 2020 181 894 0 6M0J 32225176 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2 2020-02-21 2020-03-18 Lan, J.,Ge, J.,Yu, J.,Shan, S.,Zhou, H.,Fan, S.,Zhang, Q.,Shi, X.,Wang, Q.,Zhang, L.,Wang, X. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 2020 581 215 220 6JOB Ferritin variant with ""GMG"" motif 2019-03-20 2020-03-25 Zheng, B.W.,Zhou, K.,Zhang, T.,Lv, C.,Wang, H.,Zhao, G. Self-assembly of protein nanocage into designed 2D and 3D networks by grafting amyloidogenic motifs on the exterior surfaces. To Be Published 0 0 0 0 6JOB Ferritin variant with ""GMG"" motif 2019-03-20 2020-03-25 Zheng, B.W.,Zhou, K.,Zhang, T.,Lv, C.,Wang, H.,Zhao, G. Self-assembly of protein nanocage into designed 2D and 3D networks by grafting amyloidogenic motifs on the exterior surfaces. To Be Published 0 0 0 0 6JOM 32373550 Crystal structure of lipoate protein ligase from Mycoplasma hyopneumoniae 2019-03-22 2020-03-25 Zhu, K.,Chen, H.,Jin, J.,Wang, N.,Ma, G.,Huang, J.,Feng, Y.,Xin, J.,Zhang, H.,Liu, H. Functional Identification and Structural Analysis of a New Lipoate Protein Ligase inMycoplasma hyopneumoniae. Front Cell Infect Microbiol 2020 10 156 156 6JUF 32251370 SspB crystal structure 2019-04-13 2020-03-25 Xiong, X.,Wu, G.,Wei, Y.,Liu, L.,Zhang, Y.,Su, R.,Jiang, X.,Li, M.,Gao, H.,Tian, X.,Zhang, Y.,Hu, L.,Chen, S.,Tang, Y.,Jiang, S.,Huang, R.,Li, Z.,Wang, Y.,Deng, Z.,Wang, J.,Dedon, P.C.,Chen, S.,Wang, L. SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities. Nat Microbiol 2020 5 917 928 6LF4 Crystal structure of VMB-1 bound to hydrolyzed meropenem 2019-11-28 2020-03-25 Chen, S.,Cheng, Q. Crystal structure of VMB-1 bound to hydrolyzed meropenem To Be Published 0 0 0 0 6JQ2 33537173 Crystal Structure of H2-Kb in complex with a DPAGT1 self-peptide 2019-03-28 2020-04-01 Bai, P.,Li, Y.,Zhou, Q.,Xia, J.,Wei, P.C.,Deng, H.,Wu, M.,Chan, S.K.,Kappler, J.W.,Zhou, Y.,Tran, E.,Marrack, P.,Yin, L. Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy. Oncoimmunology 2021 10 1868130 1868130 6KR2 32357182 Crystal structure of Dengue virus nonstructural protein NS5 (form 1) 2019-08-20 2020-04-01 Wu, J.,Ye, H.Q.,Zhang, Q.Y.,Lu, G.,Zhang, B.,Gong, P. A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathog. 2020 16 0 0 6KX9 32152225 Crystal structure of 8-mer peptide from avian influenza H5N1 virus in complex with BF2*1501 2019-09-10 2020-04-01 Li, X.,Zhang, L.,Liu, Y.,Ma, L.,Zhang, N.,Xia, C. Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope. J.Biol.Chem. 2020 295 5292 5306 6L1H 32234783 Crystal structure of light-dependent protochlorophyllide oxidoreductase from Thermosynechococcus elongatus 2019-09-29 2020-04-01 Dong, C.S.,Zhang, W.L.,Wang, Q.,Li, Y.S.,Wang, X.,Zhang, M.,Liu, L. Crystal structures of cyanobacterial light-dependent protochlorophyllide oxidoreductase. Proc.Natl.Acad.Sci.USA 2020 117 8455 8461 6ODB Crystal structure of HDAC8 in complex with compound 3 2019-03-26 2020-04-01 Zheng, X.,Conti, C.,Caravella, J.,Zablocki, M.-M.,Bair, K.,Barczak, N.,Han, B.,Lancia Jr., D.,Liu, C.,Martin, M.,Ng, P.Y.,Rudnitskaya, A.,Thomason, J.J.,Garcia-Dancey, R.,Hardy, C.,Lahdenranta, J.,Leng, C.,Li, P.,Pardo, E.,Saldahna, A.,Tan, T.,Toms, A.V.,Yao, L.,Zhang, C. Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors To Be Published 0 0 0 0 6JQH 32451436 Crystal structure of MaDA 2019-03-31 2020-04-08 Gao, L.,Su, C.,Du, X.,Wang, R.,Chen, S.,Zhou, Y.,Liu, C.,Liu, X.,Tian, R.,Zhang, L.,Xie, K.,Chen, S.,Guo, Q.,Guo, L.,Hano, Y.,Shimazaki, M.,Minami, A.,Oikawa, H.,Huang, N.,Houk, K.N.,Huang, L.,Dai, J.,Lei, X. FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nat.Chem. 2020 12 620 628 6JQZ ZHD/H242A complex with ZEN 2019-04-02 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6JR2 ZHD/H242A complex with aZOL 2019-04-02 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6JR5 ZHD/H242A complex with bZOL 2019-04-02 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6JR9 ZHD/W183F complex with ZEN 2019-04-03 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6JRA ZHD/W183F complex with hydrolyzed aZOL 2019-04-03 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6JRB ZHD/W183F complex with bZOL 2019-04-03 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6JRC ZHD complex with hydrolyzed alpha-ZOL 2019-04-03 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6JRD ZHD complex with hydrolyzed beta-ZOL 2019-04-03 2020-04-08 Hu, X.J.,Zhou, H.J.,Li, L. Structure of ZHD complex To Be Published 0 0 0 0 6K9C 32016421 The apo structure of NrS-1 C terminal region (305-718) 2019-06-14 2020-04-08 Chen, X.,Su, S.,Chen, Y.,Gao, Y.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Liu, H.,Li, J.,Ma, J.,Gan, J. Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase. Nucleic Acids Res. 2020 48 3343 3355 6KSF 32051560 Crystal Structure of ALKBH1 bound to 21-mer DNA bulge 2019-08-23 2020-04-08 Zhang, M.,Yang, S.,Nelakanti, R.,Zhao, W.,Liu, G.,Li, Z.,Liu, X.,Wu, T.,Xiao, A.,Li, H. Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA. Cell Res. 2020 30 197 210 6KVO 32184398 Crystal structure of chloroplast resolvase in complex with Holliday junction 2019-09-05 2020-04-08 Yan, J.,Hong, S.,Guan, Z.,He, W.,Zhang, D.,Yin, P. Structural insights into sequence-dependent Holliday junction resolution by the chloroplast resolvase MOC1. Nat Commun 2020 11 1417 1417 6LRB 32016421 The A form apo structure of NrS-1 C terminal region-CTR 2020-01-15 2020-04-08 Chen, X.,Su, S.,Chen, Y.,Gao, Y.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Liu, H.,Li, J.,Ma, J.,Gan, J. Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase. Nucleic Acids Res. 2020 48 3343 3355 6JTN 33537173 Crystal structure of HLA-C08 in complex with a tumor mut10m peptide 2019-04-11 2020-04-15 Bai, P.,Li, Y.,Zhou, Q.,Xia, J.,Wei, P.C.,Deng, H.,Wu, M.,Chan, S.K.,Kappler, J.W.,Zhou, Y.,Tran, E.,Marrack, P.,Yin, L. Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy. Oncoimmunology 2021 10 1868130 1868130 6JTO 33740187 Crystal structure of HLA-C05 in complex with a tumor mut10m peptide 2019-04-11 2020-04-15 Bai, P.,Zhou, Q.,Wei, P.,Bai, H.,Chan, S.K.,Kappler, J.W.,Marrack, P.,Yin, L. Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation. Sci China Life Sci 2021 0 0 0 6JTP 33537173 Crystal structure of HLA-C08 in complex with a tumor mut9m peptide 2019-04-11 2020-04-15 Bai, P.,Li, Y.,Zhou, Q.,Xia, J.,Wei, P.C.,Deng, H.,Wu, M.,Chan, S.K.,Kappler, J.W.,Zhou, Y.,Tran, E.,Marrack, P.,Yin, L. Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy. Oncoimmunology 2021 10 1868130 1868130 6JTQ RVD HA specifically contacts 5mC through van der Waals interactions 2019-04-11 2020-04-15 Liu, L.,Yi, C. RVD HA specifically contacts 5mC through van der Waals interactions To Be Published 0 0 0 0 6K1T 31494495 The structure of Francisella virulence factor BioJ 2019-05-12 2020-04-15 Wei, W.,Guan, H.,Zhu, T.,Zhang, S.,Fan, C.,Ouyang, S.,Feng, Y. Molecular Basis of BioJ, a Unique Gatekeeper in Bacterial Biotin Synthesis. Iscience 2019 19 796 808 6KL4 32596129 Crystal structure of MavC-UBE2N-Ub 2019-07-29 2020-04-15 Guan, H.,Fu, J.,Yu, T.,Wang, Z.X.,Gan, N.,Huang, Y.,Perculija, V.,Li, Y.,Luo, Z.Q.,Ouyang, S. Molecular Basis of Ubiquitination Catalyzed by the Bacterial Transglutaminase MavC. Adv Sci 2020 7 2000871 2000871 6L3Q Crystal structure of Chaetomium thermophilum Utp15 C terminal domain 2019-10-14 2020-04-15 Chen, R.C.,Ye, K.Q. Crystal structure of Chaetomium thermophilum Utp15 C terminal domain To Be Published 0 0 0 0 6LJV 32202425 Crystal structure of human FABP4 in complex with a novel inhibitor 2019-12-17 2020-04-15 Su, H.,Zou, Y.,Chen, G.,Dou, H.,Xie, H.,Yuan, X.,Zhang, X.,Zhang, N.,Li, M.,Xu, Y. Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation. J.Med.Chem. 2020 63 4090 4106 6JUE 32385244 The complex of PDZ and PBM 2019-04-13 2020-04-22 Liu, Z.,Yang, Y.,Gu, A.,Xu, J.,Mao, Y.,Lu, H.,Hu, W.,Lei, Q.Y.,Li, Z.,Zhang, M.,Cai, Y.,Wen, W. Par complex cluster formation mediated by phase separation. Nat Commun 2020 11 2266 2266 6JVZ 31863750 RVD HA specifically contacts 5mC through van der Waals interactions 2019-04-18 2020-04-22 Liu, L.,Zhang, Y.,Liu, M.,Wei, W.,Yi, C.,Peng, J. Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors. J.Mol.Biol. 2020 432 1035 1047 6JW0 31863750 Universal RVD R* accommodates cytosine via water-mediated interactions 2019-04-18 2020-04-22 Liu, L.,Zhang, Y.,Liu, M.,Wei, W.,Yi, C.,Peng, J. Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors. J.Mol.Biol. 2020 432 1035 1047 6K9G 32248003 Human LXR-beta in complex with an agonist 2019-06-15 2020-04-22 Chen, H.,Chen, Z.,Zhang, Z.,Li, Y.,Zhang, S.,Jiang, F.,Wei, J.,Ding, P.,Zhou, H.,Gu, Q.,Xu, J. Discovery of new LXR beta agonists as glioblastoma inhibitors. Eur.J.Med.Chem. 2020 194 112240 112240 6K9H 32248003 Human LXR-beta in complex with an agonist 2019-06-15 2020-04-22 Chen, H.,Chen, Z.,Zhang, Z.,Li, Y.,Zhang, S.,Jiang, F.,Wei, J.,Ding, P.,Zhou, H.,Gu, Q.,Xu, J. Discovery of new LXR beta agonists as glioblastoma inhibitors. Eur.J.Med.Chem. 2020 194 112240 112240 6M4J 32345643 SspA in complex with cysteine 2020-03-07 2020-04-22 Liu, L.,Jiang, S.,Xing, M.,Chen, C.,Lai, C.,Li, N.,Liu, G.,Wu, D.,Gao, H.,Hong, L.,Tan, P.,Chen, S.,Deng, Z.,Wu, G.,Wang, L. Structural Analysis of an l-Cysteine Desulfurase from an Ssp DNA Phosphorothioation System. Mbio 2020 11 0 0 6JYW Crystal structure of the transcription regulator CadR N81M mutant from P. putida in complex with Cadmium(II) and DNA 2019-04-29 2020-04-29 Liu, X.C.,Chen, H. Crystal structure of the transcription regulator CadR N81M mutant from P. putida in complex with Cadmium(II) and DNA To Be Published 0 0 0 0 6L70 32098094 Complex structure of PEDV 3CLpro with GC376 2019-10-30 2020-04-29 Ye, G.,Wang, X.,Tong, X.,Shi, Y.,Fu, Z.F.,Peng, G. Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376. Viruses 2020 12 0 0 6LBP 32174940 Structure of the Glutamine Phosphoribosylpyrophosphate Amidotransferase from Arabidopsis thaliana 2019-11-14 2020-04-29 Cao, X.,Du, B.,Han, F.,Zhou, Y.,Ren, J.,Wang, W.,Chen, Z.,Zhang, Y. Crystal Structure of the Chloroplastic Glutamine Phosphoribosylpyrophosphate Amidotransferase GPRAT2 FromArabidopsis thaliana. Front Plant Sci 2020 11 157 157 6LSF 32451382 Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6RA/C2S6RB form) 2020-01-17 2020-04-29 Wang, M.,Li, R.,Shu, B.,Jing, X.,Ye, H.Q.,Gong, P. Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun 2020 11 2605 2605 6LSG 32451382 Crystal structure of the enterovirus 71 polymerase elongation complex (C0S6M form) 2020-01-17 2020-04-29 Wang, M.,Li, R.,Shu, B.,Jing, X.,Ye, H.Q.,Gong, P. Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun 2020 11 2605 2605 6LSH 32451382 Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6M form) 2020-01-17 2020-04-29 Wang, M.,Li, R.,Shu, B.,Jing, X.,Ye, H.Q.,Gong, P. Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun 2020 11 2605 2605 7BUY 32382072 The crystal structure of COVID-19 main protease in complex with carmofur 2020-04-08 2020-04-29 Jin, Z.,Zhao, Y.,Sun, Y.,Zhang, B.,Wang, H.,Wu, Y.,Zhu, Y.,Zhu, C.,Hu, T.,Du, X.,Duan, Y.,Yu, J.,Yang, X.,Yang, X.,Yang, K.,Liu, X.,Guddat, L.W.,Xiao, G.,Zhang, L.,Yang, H.,Rao, Z. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat.Struct.Mol.Biol. 2020 27 529 532 7BWG A Glycoside Hydrolase Family 20 beta-N-Acetylglucosaminidase 2020-04-14 2020-04-29 Zhang, R.,Zhou, J.P.,Huang, Z.X. A Glycoside Hydrolase Family 20 beta-Acetylglucosaminidase To Be Published 0 0 0 0 6JQ3 33537173 Crystal Structure of H2-Kb in complex with a DPAGT1 mutant peptide 2019-03-28 2020-05-06 Bai, P.,Li, Y.,Zhou, Q.,Xia, J.,Wei, P.C.,Deng, H.,Wu, M.,Chan, S.K.,Kappler, J.W.,Zhou, Y.,Tran, E.,Marrack, P.,Yin, L. Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy. Oncoimmunology 2021 10 1868130 1868130 6JZF Structure of the intermembrane space region of PARC6 2019-05-01 2020-05-06 Feng, Y.,Liu, Z. Structure of PARC6 from Arabidopsis To Be Published 0 0 0 0 6JZN Structure of the intermembrane space region of PARC6-PDV1 2019-05-02 2020-05-06 Feng, Y.,Liu, Z. Structure of PARC6 and PDV1 complex from Arabidopsis thaliana To Be Published 0 0 0 0 6K0R 32376767 Ruvbl1-Ruvbl2 with truncated domain II in complex with phosphorylated Cordycepin 2019-05-07 2020-05-06 Ju, D.,Zhang, W.,Yan, J.,Zhao, H.,Li, W.,Wang, J.,Liao, M.,Xu, Z.,Wang, Z.,Zhou, G.,Mei, L.,Hou, N.,Ying, S.,Cai, T.,Chen, S.,Xie, X.,Lai, L.,Tang, C.,Park, N.,Takahashi, J.S.,Huang, N.,Qi, X.,Zhang, E.E. Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals. Sci Transl Med 2020 12 0 0 6J7N 32382148 Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A co-expressed with TakA from Mycobacterium tuberculosis 2019-01-18 2020-05-13 Yu, X.,Gao, X.,Zhu, K.,Yin, H.,Mao, X.,Wojdyla, J.A.,Qin, B.,Huang, H.,Wang, M.,Sun, Y.C.,Cui, S. Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol 2020 3 216 216 6J7P 32382148 Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q co-expressed with TakA from Mycobacterium tuberculosis 2019-01-18 2020-05-13 Yu, X.,Gao, X.,Zhu, K.,Yin, H.,Mao, X.,Wojdyla, J.A.,Qin, B.,Huang, H.,Wang, M.,Sun, Y.C.,Cui, S. Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol 2020 3 216 216 6J7R 32382148 Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A co-expressed with TakA from Mycobacterium tuberculosis 2019-01-18 2020-05-13 Yu, X.,Gao, X.,Zhu, K.,Yin, H.,Mao, X.,Wojdyla, J.A.,Qin, B.,Huang, H.,Wang, M.,Sun, Y.C.,Cui, S. Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Commun Biol 2020 3 216 216 6JTI Crystal structure of native NagZ from Neisseria gonorrhoeae 2019-04-11 2020-05-13 Chen, Y. Crystal structure of native NagZ from Neisseria gonorrhoeae To Be Published 0 0 0 0 6JTJ Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-acetylglucosamine 2019-04-11 2020-05-13 Chen, Y. Crystal structure of native NagZ from Neisseria gonorrhoeae in complex with N-acetylglucosamine To Be Published 0 0 0 0 6JTK Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-trifluoroacetyl-D-glucosamine 2019-04-11 2020-05-13 Chen, Y. Crystal structure of NagZ from Neisseria gonorrhoeae in complex with N-trifluoroacetyl-D-glucosamine To Be Published 0 0 0 0 6JYQ Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide 2019-04-27 2020-05-13 Buckley, B.,Jiang, L.G.,Huang, M.D.,Kelso, M.,Ranson, M. H99Y-6F-HMA-pH7 To Be Published 0 0 0 0 6JYQ Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide 2019-04-27 2020-05-13 Buckley, B.,Jiang, L.G.,Huang, M.D.,Kelso, M.,Ranson, M. H99Y-6F-HMA-pH7 To Be Published 0 0 0 0 6JYQ Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide 2019-04-27 2020-05-13 Buckley, B.,Jiang, L.G.,Huang, M.D.,Kelso, M.,Ranson, M. H99Y-6F-HMA-pH7 To Be Published 0 0 0 0 6K1N 33497694 PLP-bound form of a putative cystathionine gamma-lyase 2019-05-10 2020-05-13 Wang, Y.,Chen, H.,Huang, Z.,Yang, M.,Yu, H.,Peng, M.,Yang, Z.,Chen, S. Structural characterization of cystathionine gamma-lyase smCSE enables aqueous metal quantum dot biosynthesis. Int.J.Biol.Macromol. 2021 174 42 51 6K1O 33497694 Apo form of a putative cystathionine gamma-lyase 2019-05-10 2020-05-13 Wang, Y.,Chen, H.,Huang, Z.,Yang, M.,Yu, H.,Peng, M.,Yang, Z.,Chen, S. Structural characterization of cystathionine gamma-lyase smCSE enables aqueous metal quantum dot biosynthesis. Int.J.Biol.Macromol. 2021 174 42 51 6K8K 32398826 Crystal structure of Arabidopsis thaliana BIC2-CRY2 complex 2019-06-12 2020-05-13 Ma, L.,Wang, X.,Guan, Z.,Wang, L.,Wang, Y.,Zheng, L.,Gong, Z.,Shen, C.,Wang, J.,Zhang, D.,Liu, Z.,Yin, P. Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2. Nat.Struct.Mol.Biol. 2020 27 472 479 6KEW 32102842 Crystal structure of oxidized phosphoribulokinase from Arabidopsis thaliana 2019-07-05 2020-05-13 Yu, A.,Xie, Y.,Pan, X.,Zhang, H.,Cao, P.,Su, X.,Chang, W.,Li, M. Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle. Plant Cell 2020 32 1556 1573 6KEX 32102842 Crystal structure of reduced phosphoribulokinase from Arabidopsis thaliana 2019-07-05 2020-05-13 Yu, A.,Xie, Y.,Pan, X.,Zhang, H.,Cao, P.,Su, X.,Chang, W.,Li, M. Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle. Plant Cell 2020 32 1556 1573 6KEZ 32102842 Crystal structure of GAPDH/CP12/PRK complex from Arabidopsis thaliana 2019-07-05 2020-05-13 Yu, A.,Xie, Y.,Pan, X.,Zhang, H.,Cao, P.,Su, X.,Chang, W.,Li, M. Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle. Plant Cell 2020 32 1556 1573 6LMJ 32358196 ASFV pA104R in complex with double-strand DNA 2019-12-25 2020-05-13 Liu, R.,Sun, Y.,Chai, Y.,Li, S.,Li, S.,Wang, L.,Su, J.,Yu, S.,Yan, J.,Gao, F.,Zhang, G.,Qiu, H.J.,Gao, G.F.,Qi, J.,Wang, H. The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives. Proc.Natl.Acad.Sci.USA 2020 117 11000 11009 6LW2 32820629 The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase 2020-02-07 2020-05-13 Zhou, J.,Bie, J.,Wang, X.,Liu, Q.,Li, R.,Chen, H.,Hu, J.,Cao, H.,Ji, W.,Li, Y.,Liu, S.,Shen, Z.,Xu, B. Discovery of N -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis. J.Med.Chem. 2020 63 10307 10329 6LYW 32376247 Structural insight into the biological functions of Arabidopsis thaliana ACHT1 2020-02-16 2020-05-13 Wang, J.,Pan, W.,Cai, W.,Wang, M.,Liu, L.,Zhang, M. Structural insight into the biological functions of Arabidopsis thaliana ACHT1. Int.J.Biol.Macromol. 2020 158 43 51 6LYX 32376247 Crystal structure of oxidized ACHT1 2020-02-16 2020-05-13 Wang, J.,Pan, W.,Cai, W.,Wang, M.,Liu, L.,Zhang, M. Structural insight into the biological functions of Arabidopsis thaliana ACHT1. Int.J.Biol.Macromol. 2020 158 43 51 6M3Q 32353364 Crystal structure of AnkB/beta4-spectrin complex 2020-03-04 2020-05-13 Li, J.,Chen, K.,Zhu, R.,Zhang, M. Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins. J.Mol.Biol. 2020 432 3838 3850 7BRO 32887884 Crystal structure of the 2019-nCoV main protease 2020-03-29 2020-05-13 Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F. Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun 2020 11 4417 4417 7BRP 32887884 Crystal structure of the 2019-nCoV main protease complexed with Boceprevir 2020-03-29 2020-05-13 Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F. Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun 2020 11 4417 4417 7BZ5 32404477 Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody 2020-04-26 2020-05-13 Wu, Y.,Wang, F.,Shen, C.,Peng, W.,Li, D.,Zhao, C.,Li, Z.,Li, S.,Bi, Y.,Yang, Y.,Gong, Y.,Xiao, H.,Fan, Z.,Tan, S.,Wu, G.,Tan, W.,Lu, X.,Fan, C.,Wang, Q.,Liu, Y.,Zhang, C.,Qi, J.,Gao, G.F.,Gao, F.,Liu, L. A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2. Science 2020 368 1274 1278 6JDT Crystal structure of GH10 family xylanase XynAF1 from Aspergillus fumigatus Z5 2019-02-02 2020-05-20 Li, G.,Miao, Y.,Zhang, R. Crystal structure of GH10 family xylanase XynAF1 from Aspergillus fumigatus Z5 To Be Published 0 0 0 0 6JDY Ligand complex structure of GH10 family xylanase XynAF1, soaking for 120 minutes 2019-02-02 2020-05-20 Li, G.,Miao, Y.,Zhang, R. Crystal structure of GH10 family xylanase XynAF1 from Aspergillus fumigatus Z5 To Be Published 0 0 0 0 6JHP Crystal structure of the glycoside hydrolase family 36 alpha-galactosidase from Paecilomyces thermophila 2019-02-18 2020-05-20 Liu, Y.,Huang, P.,Ma, J.,Jiang, Z. Crystal structure and phylogenetic analysis of the glycoside hydrolase family 36 alpha-galactosidase from Paecilomyces thermophila To be published 0 0 0 0 6K3E LSD1/Co-Rest structure with an inhibitor 2019-05-17 2020-05-20 Wang, J. LSD1/Co-Rest structure with an inhibitor To Be Published 0 0 0 0 7C2A Crystal structure of AlinE4, a SGNH-hydrolase family esterase 2020-05-07 2020-05-20 Li, Z.,Li, J. C-terminal swapped dimers revealed a new catalytic mechanism of SGNH-hydrolase family esterases To Be Published 0 0 0 0 7C2C Esterase AlinE4 mutant, D162A 2020-05-07 2020-05-20 Li, Z.,Li, J. C-terminal swapped dimers revealed a new catalytic mechanism of SGNH-hydrolase family esterases To Be Published 0 0 0 0 7C2D Esterase AlinE4 mutant-S13A 2020-05-07 2020-05-20 Li, Z.,Li, J. C-terminal swapped dimers revealed a new catalytic mechanism of SGNH-hydrolase family esterases To Be Published 0 0 0 0 6LKX 32461315 The structure of PRRSV helicase 2019-12-20 2020-05-27 Shi, Y.,Tong, X.,Ye, G.,Xiu, R.,Li, L.,Sun, L.,Shi, J.,Li, M.,Song, Y.,Fan, C.,Shi, K.,Fu, Z.F.,Xiao, S.,Peng, G. Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus. J.Virol. 2020 94 0 0 6LPM 33117296 Crystal structure of AP endonuclease from Deinococcus radioduran 2020-01-11 2020-05-27 He, Y.,Wang, Y.,Qin, C.,Xu, Y.,Cheng, K.,Xu, H.,Tian, B.,Zhao, Y.,Wang, L.,Hua, Y. Structural and Functional Characterization of a Unique AP Endonuclease From Deinococcus radiodurans . Front Microbiol 2020 11 1178 1178 7C01 32454512 Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD 2020-04-29 2020-05-27 Shi, R.,Shan, C.,Duan, X.,Chen, Z.,Liu, P.,Song, J.,Song, T.,Bi, X.,Han, C.,Wu, L.,Gao, G.,Hu, X.,Zhang, Y.,Tong, Z.,Huang, W.,Liu, W.J.,Wu, G.,Zhang, B.,Wang, L.,Qi, J.,Feng, H.,Wang, F.S.,Wang, Q.,Gao, G.F.,Yuan, Z.,Yan, J. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature 2020 584 120 124 6K5S Crystal structure of the Helical domain of S. pombe Tbf1 2019-05-31 2020-06-03 Zhou, Y.Z.,Wang, N.N.,Zhao, Y.C.,Zeng, Z.X. Crystal structure of the Helical domain of S. pombe Tbf1 To Be Published 0 0 0 0 6K5X Crystal Structure of the DNA-Binding Domain of GapR 2019-05-31 2020-06-03 Xia, B.,Huang, Q. Crystal Structure of the DNA-Binding Domain of GapR To Be Published 0 0 0 0 6KHY 32194979 The crystal structure of AsfvAP:AG 2019-07-16 2020-06-03 Chen, Y.,Chen, X.,Huang, Q.,Shao, Z.,Gao, Y.,Li, Y.,Yang, C.,Liu, H.,Li, J.,Wang, Q.,Ma, J.,Zhang, Y.Z.,Gu, Y.,Gan, J. A unique DNA-binding mode of African swine fever virus AP endonuclease. Cell Discov 2020 6 13 13 6KJB 31947715 wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167 2019-07-22 2020-06-03 Lei, Z.,Wang, N.,Tan, H.,Zheng, J.,Jia, Z. Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation. Int J Mol Sci 2020 21 0 0 6KJB 31947715 wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167 2019-07-22 2020-06-03 Lei, Z.,Wang, N.,Tan, H.,Zheng, J.,Jia, Z. Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation. Int J Mol Sci 2020 21 0 0 6L77 32415887 Crystal structure of MS5 from Brassica napus 2019-10-31 2020-06-03 Wang, X.,Gao, Y.,Guan, Z.,Xie, Z.,Zhang, D.,Yin, P.,Yang, G.,Hong, D.,Xin, Q. Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds. Febs Lett. 2020 594 2462 2471 6M1V 32482145 Crystal structure of post fusion core of 2019-nCoV S2 subunit 2020-02-26 2020-06-03 Sun, H.,Li, Y.,Liu, P.,Qiao, C.,Wang, X.,Wu, L.,Liu, K.,Hu, Y.,Su, C.,Tan, S.,Zou, S.,Wu, G.,Yan, J.,Gao, G.F.,Qi, J.,Wang, Q. Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry. Emerg Microbes Infect 2020 9 1238 1241 7BWJ 32454513 crystal structure of SARS-CoV-2 antibody with RBD 2020-04-14 2020-06-03 Ju, B.,Zhang, Q.,Ge, J.,Wang, R.,Sun, J.,Ge, X.,Yu, J.,Shan, S.,Zhou, B.,Song, S.,Tang, X.,Yu, J.,Lan, J.,Yuan, J.,Wang, H.,Zhao, J.,Zhang, S.,Wang, Y.,Shi, X.,Liu, L.,Zhao, J.,Wang, X.,Zhang, Z.,Zhang, L. Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature 2020 584 115 119 7C49 32873764 nicA2 with cofactor FAD and substrate nicotine 2020-05-15 2020-06-03 Tang, H.,Zhang, K.,Hu, H.,Wu, G.,Wang, W.,Zhu, X.,Liu, G.,Xu, P. Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022). Mbio 2020 11 0 0 7C4A 32873764 nicA2 with cofactor FAD 2020-05-15 2020-06-03 Tang, H.,Zhang, K.,Hu, H.,Wu, G.,Wang, W.,Zhu, X.,Liu, G.,Xu, P. Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022). Mbio 2020 11 0 0 6K7Q Crystal structure of thymidylate synthase from shrimp 2019-06-08 2020-06-10 Liu, C.,Zang, K.,Li, S.,Li, F.,Ma, Q. Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed. J Oceanol Limnol 2020 38 1891 1899 6K7R Crystal structure of thymidylate synthase from shrimp 2019-06-08 2020-06-10 Liu, C.,Zang, K.,Li, S.,Li, F.,Ma, Q. Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed. J Oceanol Limnol 2020 38 1891 1899 6KKP 32090355 The crystal structure of apo-SiaC from Pseudomonas aeruginosa 2019-07-26 2020-06-10 Chen, G.K.,Gan, J.H.,Yang, C.,Zuo, Y.L.,Peng, J.,Li, M.,Huo, W.P.,Xie, Y.P.,Zhang, Y.N.,Wang, T.T.,Deng, X.,Liang, H.H. The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa. Embo J. 2020 39 0 0 6L8H 32513704 Crystal structure of CYP97C1 2019-11-06 2020-06-10 Niu, G.,Guo, Q.,Wang, J.,Zhao, S.,He, Y.,Liu, L. Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA 2020 117 14150 14157 6LH8 32499370 Structure of aerolysin-like protein (Bombina maxima) 2019-12-07 2020-06-10 Wang, Q.,Bian, X.,Zeng, L.,Pan, F.,Liu, L.,Liang, J.,Wang, L.,Zhou, K.,Lee, W.,Xiang, Y.,Li, S.,Teng, M.,Li, X.,Guo, X.,Zhang, Y. A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. J.Biol.Chem. 2020 295 10293 10306 6LHZ 32499370 Structure of aerolysin-like protein (Bombina maxima) 2019-12-10 2020-06-10 Wang, Q.,Bian, X.,Zeng, L.,Pan, F.,Liu, L.,Liang, J.,Wang, L.,Zhou, K.,Lee, W.,Xiang, Y.,Li, S.,Teng, M.,Li, X.,Guo, X.,Zhang, Y. A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. J.Biol.Chem. 2020 295 10293 10306 7C3Q Human MdmX protein in complex with Nutlin3a 2020-05-13 2020-06-10 Su, Z.D.,Cheng, X.Y.,Zhang, B.L.,Kuang, Z.K.,Yang, J.,Li, Z.C.,Yu, J.P.,Zhao, Z.T.,Cao, C.Z. Human MdmX protein in complex with Nutlin3a To Be Published 0 0 0 0 6K9A The complex of NrS-1 N terminal domain (1-305) with dGTP 2019-06-14 2020-06-17 Chen, X.,Gan, J. Structural studies reveal a unique ring-shaped helicase architecture at the C-terminus of deep-sea vent phage DNA polymerase To Be Published 0 0 0 0 6K9B Apo structure of NrS-1 N terminal domain N305 2019-06-14 2020-06-17 Chen, X.,Gan, J. Structural studies reveal a unique ring-shaped helicase architecture at the C-terminus of deep-sea vent phage DNA polymerase To Be Published 0 0 0 0 6K9E 32016421 The A form apo structure of NrS-1 C terminal region-CTR(305-718) 2019-06-14 2020-06-17 Chen, X.,Su, S.,Chen, Y.,Gao, Y.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Liu, H.,Li, J.,Ma, J.,Gan, J. Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase. Nucleic Acids Res. 2020 48 3343 3355 6K9M 32961480 Human LXR-beta in complex with an agonist 2019-06-16 2020-06-17 Chen, Z.,Chen, H.,Zhang, Z.,Ding, P.,Yan, X.,Li, Y.,Zhang, S.,Gu, Q.,Zhou, H.,Xu, J. Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors. Eur.J.Med.Chem. 2020 206 112793 112793 6KA0 Silver-bound E.coli Malate dehydrogenase 2019-06-19 2020-06-17 Wang, H.,Wang, M.,Sun, H. MDH is a major silver target in E. coli To Be Published 0 0 0 0 6KA1 E.coli Malate dehydrogenase 2019-06-19 2020-06-17 Wang, H.,Wang, M.,Sun, H. MDH is a major silver target in E. coli To Be Published 0 0 0 0 6L5M 32714761 Crystal structure of human DEAD-box RNA helicase DDX21 in complex with AMP 2019-10-24 2020-06-17 Chen, Z.,Li, Z.,Hu, X.,Xie, F.,Kuang, S.,Zhan, B.,Gao, W.,Chen, X.,Gao, S.,Li, Y.,Wang, Y.,Qian, F.,Ding, C.,Gan, J.,Ji, C.,Xu, X.,Zhou, Z.,Huang, J.,He, H.H.,Li, J. Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci 2020 7 2000532 2000532 6LOI 32437130 Crystal structure of Enterococcus faecalis Undecaprenyl pyrophosphate synthase(EfaUPPS) 2020-01-05 2020-06-17 Li, W.,Li, L.,Zhang, C.,Cai, Y.,Gao, Q.,Wang, F.,Cao, Y.,Lin, J.,Li, J.,Shang, Z.,Lin, W. Investigations into the Antibacterial Mechanism of Action of Viridicatumtoxins. Acs Infect Dis. 2020 6 1759 1769 6M5I Crystal structure of 2019-nCoV nsp7-nsp8c complex 2020-03-10 2020-06-17 Yan, L.M.,Ge, J.,Lou, Z.Y.,Rao, Z.H. Crystal structure of 2019-nCoV nsp7-nsp8c complex To Be Published 0 0 0 0 7BQ7 Crystal structure of 2019-nCoV nsp16-nsp10 complex 2020-03-24 2020-06-17 Yan, L.M.,Huang, Y.C.,Lou, Z.Y.,Rao, Z.H. Crystal structure of 2019-nCoV nsp16-nsp10 complex To Be Published 0 0 0 0 7BTA 32470140 Crystal structure of Rheb D60K mutant bound to GDP 2020-03-31 2020-06-17 Zhang, C.,Liu, Y.,Zhang, Y.,Wang, X.,Zhang, T.,Ding, J. Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling. J Mol Cell Biol 2020 12 741 744 7BWN 32506656 Crystal Structure of a Designed Protein Heterocatenane 2020-04-15 2020-06-17 Liu, Y.,Duan, Z.,Fang, J.,Zhang, F.,Xiao, J.,Zhang, W.B. Cellular Synthesis and X-ray Crystal Structure of a Designed Protein Heterocatenane. Angew.Chem.Int.Ed.Engl. 2020 59 16122 16127 7C3Y Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a 2020-05-14 2020-06-17 Su, Z.D.,Cheng, X.Y.,Zhang, B.L.,Kuang, Z.K.,Yang, J.,Li, Z.C.,Yu, J.P.,Cao, C.Z.,Zhao, Z.T. Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a To Be Published 0 0 0 0 7C44 Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a 2020-05-15 2020-06-17 Cheng, X.Y.,Zhang, B.L.,Kuang, Z.K.,Yang, J.,Li, Z.C.,Yu, J.P.,Zhao, Z.T.,Cao, C.Z.,Su, Z.D. Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a To Be Published 0 0 0 0 6IVA 32459174 Crystal structure of the S. typhimurium oxaloacetate decarboxylase beta-gamma sub-complex 2018-12-03 2020-06-24 Xu, X.,Shi, H.,Gong, X.,Chen, P.,Gao, Y.,Zhang, X.,Xiang, S. Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump. Elife 2020 9 0 0 6K8N Crystal structure of the Sulfolobus solfataricus topoisomerase III 2019-06-13 2020-06-24 Wang, H.Q.,Zhang, J.H.,Zheng, X.,Zheng, Z.F.,Dong, Y.H.,Huang, L.,Gong, Y. Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain To Be Published 0 0 0 0 6KCV 31682837 Structure of alginate lyase Aly36B mutant K143A/Y185A in complex with alginate tetrasaccharide 2019-06-29 2020-06-24 Dong, F.,Xu, F.,Chen, X.L.,Li, P.Y.,Li, C.Y.,Li, F.C.,Chen, Y.,Wang, P.,Zhang, Y.Z. Alginate Lyase Aly36B is a New Bacterial Member of the Polysaccharide Lyase Family 36 and Catalyzes by a Novel Mechanism With Lysine as Both the Catalytic Base and Catalytic Acid. J.Mol.Biol. 2019 431 4897 4909 6KCW 31682837 Structure of alginate lyase Aly36B 2019-06-29 2020-06-24 Dong, F.,Xu, F.,Chen, X.L.,Li, P.Y.,Li, C.Y.,Li, F.C.,Chen, Y.,Wang, P.,Zhang, Y.Z. Alginate Lyase Aly36B is a New Bacterial Member of the Polysaccharide Lyase Family 36 and Catalyzes by a Novel Mechanism With Lysine as Both the Catalytic Base and Catalytic Acid. J.Mol.Biol. 2019 431 4897 4909 7BQ9 Crystal structure of ASFV p15 2020-03-24 2020-06-24 Fu, D.,Guo, Y. Structure of a bifunctional membrane-DNA binding protein, African swine fever virus p15 Protein Cell 2020 0 0 0 7BQA 32519301 Crystal structure of ASFV p35 2020-03-24 2020-06-24 Li, G.,Fu, D.,Zhang, G.,Zhao, D.,Li, M.,Geng, X.,Sun, D.,Wang, Y.,Chen, C.,Jiao, P.,Cao, L.,Guo, Y.,Rao, Z. Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly. Protein Cell 2020 11 600 605 7BVV 32531362 Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 2020-04-11 2020-07-01 Lian, F.M.,Jiang, Y.L.,Yang, W.,Yang, X. Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 mimics a conformational intermediate during the catalytic cycle. Int.J.Biol.Macromol. 2020 161 1055 1060 6KBW 33771875 Crystal structure of Tmm from Myroides profundi D25 2019-06-26 2020-07-08 Qin, Q.L.,Wang, Z.B.,Su, H.N.,Chen, X.L.,Miao, J.,Wang, X.J.,Li, C.Y.,Zhang, X.Y.,Li, P.Y.,Wang, M.,Fang, J.,Lidbury, I.,Zhang, W.,Zhang, X.H.,Yang, G.P.,Chen, Y.,Zhang, Y.Z. Oxidation of trimethylamine to trimethylamine N-oxide facilitates high hydrostatic pressure tolerance in a generalist bacterial lineage. Sci Adv 2021 7 0 0 6KDC crystal structure of Fpglu1 from fervidobacterium pennivoraus 2019-07-02 2020-07-08 Yu, S. crystal structure of fpglu1 To Be Published 0 0 0 0 6KDD endoglucanase 2019-07-02 2020-07-08 Yu, S. crystal structure of an endoglucanase from Fervidobacterium pennivorans DSM9078 To Be Published 0 0 0 0 6KDQ Crystal structure of human NRMT1 in complex with alpha-N-monomethylated human CENP-A peptide 2019-07-02 2020-07-08 Wu, R.,Yue, Y.,Zheng, X.,Li, H. Substrate engagement regulates state-specific alpha-N methylation of CENP-A by NRMT2 to be published 0 0 0 0 6KDR Crystal structure of human NRMT2 in complex with human centromere protein B peptide 2019-07-02 2020-07-08 Wu, R.,Yue, Y.,Zheng, X.,Li, H. Substrate-enzyme engagement regulates state-specific alpha-N methylation of NRMT2 to be published 0 0 0 0 6KDS Crystal structure of human NRMT2 in complex with alpha-N-monomethylated human CENP-A peptide 2019-07-02 2020-07-08 Wu, R.,Yue, Y.,Zheng, X.,Li, H. Substrate engagement regulates state-specific alpha-N methylation of CENP-A by NRMT2 To be published 0 0 0 0 6KEE Crystal structure of BRD4 Bromodomain1 with an inhibitor 2019-07-04 2020-07-08 Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C. Crystal structure of BRD4 Bromodomain1 with an inhibitor To be published 0 0 0 0 6KEG BRD4 Bromodomain1 with an inhibitor 2019-07-04 2020-07-08 Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C. BRD4 Bromodomain1 with an inhibitor To Be Published 0 0 0 0 6KEU Wildtype E53, a microbial HSL esterase 2019-07-05 2020-07-08 Yang, X.C.,Yingyi, H.,Li, Z.Y.,Shuling, J.,Zhen, R.,Zhao, W.,Henglin, C.,Li, J.X.,Xu, X.W. Wildtype E53, a microbial HSL esterase To Be Published 0 0 0 0 6KGD 33097546 Crystal structure of CaDoc0917(R49D)-CaCohA2 complex at pH 8.0 2019-07-11 2020-07-08 Yao, X.,Chen, C.,Wang, Y.,Dong, S.,Liu, Y.J.,Li, Y.,Cui, Z.,Gong, W.,Perrett, S.,Yao, L.,Lamed, R.,Bayer, E.A.,Cui, Q.,Feng, Y. Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules. Sci Adv 2020 6 0 0 6KGE 33097546 Crystal structure of CaDoc0917(R16D)-CaCohA2 complex at pH 5.5 2019-07-11 2020-07-08 Yao, X.,Chen, C.,Wang, Y.,Dong, S.,Liu, Y.J.,Li, Y.,Cui, Z.,Gong, W.,Perrett, S.,Yao, L.,Lamed, R.,Bayer, E.A.,Cui, Q.,Feng, Y. Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules. Sci Adv 2020 6 0 0 6KOI 32561432 Crystal structure of SNX11-PXe domain in dimer form. 2019-08-11 2020-07-08 Xu, T.,Gan, Q.,Wu, B.,Yin, M.,Xu, J.,Shu, X.,Liu, J. Molecular Basis for PI(3,5)P2Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. J.Mol.Biol. 2020 432 4750 4761 6KOJ 32561432 Crystal structure of SNX11-PXe domain in complex with PI(3,5)P2 2019-08-11 2020-07-08 Xu, T.,Gan, Q.,Wu, B.,Yin, M.,Xu, J.,Shu, X.,Liu, J. Molecular Basis for PI(3,5)P2Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. J.Mol.Biol. 2020 432 4750 4761 6M3B 32532974 hAPC-c25k23 Fab complex 2020-03-03 2020-07-08 Zhao, X.Y.,Wilmen, A.,Wang, D.,Wang, X.,Bauzon, M.,Kim, J.Y.,Linden, L.,Li, L.,Egner, U.,Marquardt, T.,Moosmayer, D.,Tebbe, J.,Gluck, J.M.,Ellinger, P.,McLean, K.,Yuan, S.,Yegneswaran, S.,Jiang, X.,Evans, V.,Gu, J.M.,Schneider, D.,Zhu, Y.,Xu, Y.,Mallari, C.,Hesslein, A.,Wang, Y.,Schmidt, N.,Gutberlet, K.,Ruehl-Fehlert, C.,Freyberger, A.,Hermiston, T.,Patel, C.,Sim, D.,Mosnier, L.O.,Laux, V. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. Nat Commun 2020 11 2992 2992 6M3C 32532974 hAPC-h1573 Fab complex 2020-03-03 2020-07-08 Zhao, X.Y.,Wilmen, A.,Wang, D.,Wang, X.,Bauzon, M.,Kim, J.Y.,Linden, L.,Li, L.,Egner, U.,Marquardt, T.,Moosmayer, D.,Tebbe, J.,Gluck, J.M.,Ellinger, P.,McLean, K.,Yuan, S.,Yegneswaran, S.,Jiang, X.,Evans, V.,Gu, J.M.,Schneider, D.,Zhu, Y.,Xu, Y.,Mallari, C.,Hesslein, A.,Wang, Y.,Schmidt, N.,Gutberlet, K.,Ruehl-Fehlert, C.,Freyberger, A.,Hermiston, T.,Patel, C.,Sim, D.,Mosnier, L.O.,Laux, V. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. Nat Commun 2020 11 2992 2992 6RP8 Crystal Structure of Ipilimumab Fab complexed with CTLA-4 at 2.6A resolution 2019-05-14 2020-07-08 Zhang, F.,Zhou, A. Crystal Structure of Ipilimumab Fab complexed with CTLA-4 at 2.6A resolution To Be Published 0 0 0 0 6RQM A blocking anti-CTLA-4 Nanobody (KN044) complexed with CTLA-4 2019-05-16 2020-07-08 Gao, H.,Zhou, A. A blocking anti-CTLA-4 Nanobody (KN044) complexed with CTLA-4 To Be Published 0 0 0 0 7C82 32549911 Crystal structure of AlinE4, a SGNH-hydrolase family esterase 2020-05-28 2020-07-08 Li, Z.,Li, L.,Huo, Y.,Chen, Z.,Zhao, Y.,Huang, J.,Jian, S.,Rong, Z.,Wu, D.,Gan, J.,Hu, X.,Li, J.,Xu, X.W. Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels 2020 13 107 107 7C84 32549911 Esterase AlinE4 mutant, D162A 2020-05-28 2020-07-08 Li, Z.,Li, L.,Huo, Y.,Chen, Z.,Zhao, Y.,Huang, J.,Jian, S.,Rong, Z.,Wu, D.,Gan, J.,Hu, X.,Li, J.,Xu, X.W. Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels 2020 13 107 107 7C85 32549911 Esterase AlinE4 mutant-S13A 2020-05-28 2020-07-08 Li, Z.,Li, L.,Huo, Y.,Chen, Z.,Zhao, Y.,Huang, J.,Jian, S.,Rong, Z.,Wu, D.,Gan, J.,Hu, X.,Li, J.,Xu, X.W. Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels 2020 13 107 107 6LFC 32339761 E. coli Thioesterase I mutant DG 2019-12-01 2020-07-15 Deng, X.,Chen, L.,Hei, M.,Liu, T.,Feng, Y.,Yang, G.Y. Structure-guided reshaping of the acyl binding pocket of 'TesA thioesterase enhances octanoic acid production in E. coli. Metab. Eng. 2020 61 24 32 6LL9 32609505 Crystal structure of D-alanine-D-alanine ligase from Aeromonas hydrophila 2019-12-22 2020-07-15 Zhang, Y.,Gong, S.,Wang, X.,Muhammad, M.,Li, Y.,Meng, S.,Li, Q.,Liu, D.,Zhang, H. Insights into the Inhibition ofAeromonas hydrophilad-Alanine-d-Alanine Ligase by Integration of Kinetics and Structural Analysis. J.Agric.Food Chem. 2020 68 7509 7519 6KIR High resolution structure of mouse CXorf40A 2019-07-19 2020-07-22 Wu, B.X. High resolution structure of mouse CXorf40A To Be Published 0 0 0 0 6KIS High-resolution structure of mouse CXorf40A (soaked with Methylmercury chloride) 2019-07-19 2020-07-22 Wu, B.X. High-resolution structure of mouse CXorf40A (soaked with Methylmercury chloride) To Be Published 0 0 0 0 6LBJ 32633758 Structure of mouse GLD-2 (Terminal nucleotidyltransferase 2, TENT2) 2019-11-14 2020-07-22 Ma, X.Y.,Zhang, H.,Feng, J.X.,Hu, J.L.,Yu, B.,Luo, L.,Cao, Y.L.,Liao, S.,Wang, J.,Gao, S. Structures of mammalian GLD-2 proteins reveal molecular basis of their functional diversity in mRNA and microRNA processing. Nucleic Acids Res. 2020 48 8782 8795 6KJH 32803979 Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 2019-07-22 2020-07-29 Xiao, F.,Dong, S.,Liu, Y.,Feng, Y.,Li, H.,Yun, C.H.,Cui, Q.,Li, W. Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc. 2020 142 16031 16038 6KJJ 32803979 Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 2019-07-22 2020-07-29 Xiao, F.,Dong, S.,Liu, Y.,Feng, Y.,Li, H.,Yun, C.H.,Cui, Q.,Li, W. Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc. 2020 142 16031 16038 6KJP 32803979 Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 2019-07-23 2020-07-29 Xiao, F.,Dong, S.,Liu, Y.,Feng, Y.,Li, H.,Yun, C.H.,Cui, Q.,Li, W. Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc. 2020 142 16031 16038 6KJQ 32803979 Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 2019-07-23 2020-07-29 Xiao, F.,Dong, S.,Liu, Y.,Feng, Y.,Li, H.,Yun, C.H.,Cui, Q.,Li, W. Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc. 2020 142 16031 16038 6KJR 32803979 Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 2019-07-23 2020-07-29 Xiao, F.,Dong, S.,Liu, Y.,Feng, Y.,Li, H.,Yun, C.H.,Cui, Q.,Li, W. Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc. 2020 142 16031 16038 6KJT 32803979 Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors 2019-07-23 2020-07-29 Xiao, F.,Dong, S.,Liu, Y.,Feng, Y.,Li, H.,Yun, C.H.,Cui, Q.,Li, W. Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc. 2020 142 16031 16038 6KKK 33280821 Crystal structure of Drug:Proton Antiporter-1 (DHA1) Family SotB, in the inward open conformation (H115A mutant) 2019-07-26 2020-07-29 Xiao, Q.,Sun, B.,Zhou, Y.,Wang, C.,Guo, L.,He, J.,Deng, D. Visualizing the nonlinear changes of a drug-proton antiporter from inward-open to occluded state. Biochem.Biophys.Res.Commun. 2021 534 272 278 7C02 32645327 Crystal structure of dimeric MERS-CoV receptor binding domain 2020-04-30 2020-07-29 Dai, L.,Zheng, T.,Xu, K.,Han, Y.,Xu, L.,Huang, E.,An, Y.,Cheng, Y.,Li, S.,Liu, M.,Yang, M.,Li, Y.,Cheng, H.,Yuan, Y.,Zhang, W.,Ke, C.,Wong, G.,Qi, J.,Qin, C.,Yan, J.,Gao, G.F. A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS. Cell 2020 182 722 0 7C37 32698064 Crystal structure of AofleA from Arthrobotrys oligospora 2020-05-11 2020-07-29 Liu, M.,Cheng, X.,Wang, J.,Tian, D.,Tang, K.,Xu, T.,Zhang, M.,Wang, Y.,Wang, M. Structural insights into the fungi-nematodes interaction mediated by fucose-specific lectin AofleA from Arthrobotrys oligospora. Int.J.Biol.Macromol. 2020 164 783 793 7C38 32698064 Crystal structure of AofleA from Arthrobotrys oligospora in complex with L-fucose 2020-05-11 2020-07-29 Liu, M.,Cheng, X.,Wang, J.,Tian, D.,Tang, K.,Xu, T.,Zhang, M.,Wang, Y.,Wang, M. Structural insights into the fungi-nematodes interaction mediated by fucose-specific lectin AofleA from Arthrobotrys oligospora. Int.J.Biol.Macromol. 2020 164 783 793 7C39 32698064 Crystal structure of AofleA from Arthrobotrys oligospora in complex with methylated L-fucose 2020-05-11 2020-07-29 Liu, M.,Cheng, X.,Wang, J.,Tian, D.,Tang, K.,Xu, T.,Zhang, M.,Wang, Y.,Wang, M. Structural insights into the fungi-nematodes interaction mediated by fucose-specific lectin AofleA from Arthrobotrys oligospora. Int.J.Biol.Macromol. 2020 164 783 793 6JYK 32756896 Crystal Structure of C. crescentus free GapR 2019-04-26 2020-08-05 Huang, Q.,Duan, B.,Dong, X.,Fan, S.,Xia, B. GapR binds DNA through dynamic opening of its tetrameric interface. Nucleic Acids Res. 2020 48 9372 9386 6K2J 32756896 Crystal Structure of the DNA Complex of C. crescentus GapR 2019-05-14 2020-08-05 Huang, Q.,Duan, B.,Dong, X.,Fan, S.,Xia, B. GapR binds DNA through dynamic opening of its tetrameric interface. Nucleic Acids Res. 2020 48 9372 9386 6KMH 33318489 The crystal structure of CASK/Mint1 complex 2019-07-31 2020-08-05 Zhang, Z.,Li, W.,Yang, G.,Lu, X.,Qi, X.,Wang, S.,Cao, C.,Zhang, P.,Ren, J.,Zhao, J.,Zhang, J.,Hong, S.,Tan, Y.,Burchfield, J.,Yu, Y.,Xu, T.,Yao, X.,James, D.,Feng, W.,Chen, Z. CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discov 2020 6 92 92 6L08 Crystal structure of Arabidopsis cytidine deaminase 2019-09-26 2020-08-05 Wang, J.,Guo, Q.,Liu, L.,Wang, X. Crystal structure of Arabidopsis thaliana cytidine deaminase. Biochem.Biophys.Res.Commun. 2020 529 659 665 6LAD 32736072 Crystal structure of Amuc_1100 from Akkermansia muciniphila 2019-11-12 2020-08-05 Wang, J.,Xiang, R.,Wang, R.,Zhang, B.,Gong, W.,Zhang, J.,Zhang, M.,Wang, M. The variable oligomeric state of Amuc_1100 from Akkermansia muciniphila. J.Struct.Biol. 2020 212 107593 107593 7C5Z 32434890 Crystal structure of spring viremia of carp virus phosphoprotein central domain 2020-05-21 2020-08-05 Wang, Z.X.,Liu, S.B.,Guan, H.,Lu, L.F.,Tu, J.G.,Ouyang, S.,Zhang, Y.A. Structural and Functional Characterization of the Phosphoprotein Central Domain of Spring Viremia of Carp Virus. J.Virol. 2020 94 0 0 7CM2 The Crystal Structure of human USP7 USP domain from Biortus 2020-07-24 2020-08-05 Wang, F.,Cheng, W.,Lv, Z.,Lin, D.,Zhu, B.,Miao, Q.,Bao, X.,Shang, H. The Crystal Structure of human USP7 USP domain from Biortus. To Be Published 0 0 0 0 6KO2 Crystal Structure of BRD4-Brmo2 in complex with H2A.ZK4acK7ac peptide 2019-08-07 2020-08-12 Zheng, S.P.,Li, H.T. Crystal Structure of BRD4-Bromo2 in complex with H2A.ZK4acK7ac peptide To be published 0 0 0 0 7CBN Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila 2020-06-13 2020-08-12 Xu, W.,Yang, W.,Wang, Y.,Wang, M.,Zhang, M. Structural and biochemical analyses of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila involved in mucin degradation. Biochem.Biophys.Res.Commun. 2020 529 876 881 7CMR The Crystal Structure of human MYST1 from Biortus. 2020-07-28 2020-08-12 Wang, F.,Lin, D.,Lv, Z.,Xu, X.,Tan, J.,Shang, H. The Crystal Structure of human MYST1 from Biortus. To Be Published 0 0 0 0 6KX3 32714746 Crystal structure of RhoA protein with covalent inhibitor DC-Rhoin 2019-09-09 2020-08-19 Sun, Z.,Zhang, H.,Zhang, Y.,Liao, L.,Zhou, W.,Zhang, F.,Lian, F.,Huang, J.,Xu, P.,Zhang, R.,Lu, W.,Zhu, M.,Tao, H.,Yang, F.,Ding, H.,Chen, S.,Yue, L.,Zhou, B.,Zhang, N.,Tan, M.,Jiang, H.,Chen, K.,Liu, B.,Liu, C.,Dang, Y.,Luo, C. Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. Adv Sci 2020 7 2000098 2000098 7BRC 32744250 Crystal structure of the TMK3 LRR domain 2020-03-27 2020-08-19 Chen, H.,Kong, Y.,Chen, J.,Li, L.,Li, X.,Yu, F.,Ming, Z. Crystal structure of the extracellular domain of the receptor-like kinase TMK3 from Arabidopsis thaliana. Acta Crystallogr.,Sect.F 2020 76 384 390 6LRD 32870272 Structure of RecJ complexed with a 5'-P-dSpacer-modified ssDNA 2020-01-16 2020-08-26 Cheng, K.,Xu, Y.,Chen, X.,Lu, H.,He, Y.,Wang, L.,Hua, Y. Participation of RecJ in the base excision repair pathway of Deinococcus radiodurans. Nucleic Acids Res. 2020 48 9859 9871 6KRJ Crystal structure of Hexokinase 2019-08-22 2020-09-02 Sun, M.F.,Wang, Y.H.,Liao, S.Q.,Yuan, H. Crystal structure of Hexokinase To Be Published 0 0 0 0 6KTH 33249150 Crystal structure of Juvenile hormone diol kinase JHDK-L2 from silkworm, Bombyx mori 2019-08-28 2020-09-02 Xu, H.,Zhang, Y.,Zhang, L.,Wang, Z.,Guo, P.,Zhao, P. Structural characterization and functional analysis of juvenile hormone diol kinase from the silkworm, Bombyx mori. Int.J.Biol.Macromol. 2021 167 570 577 6KUE 33824341 The structure of BioZ from Agrobacterium tumefaciens 2019-09-01 2020-09-02 Zhang, S.,Xu, Y.,Guan, H.,Cui, T.,Liao, Y.,Wei, W.,Li, J.,Hassan, B.H.,Zhang, H.,Jia, X.,Ouyang, S.,Feng, Y. Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway. Nat Commun 2021 12 2056 2056 6L5D 32375647 Crystal structure of the gas vesicle protein GvpF from Anabaena sp. PCC7120 2019-10-23 2020-09-02 Cai, K.,Xu, B.Y.,Jiang, Y.L.,Wang, Y.,Chen, Y.,Zhou, C.Z.,Li, Q. The model cyanobacteria Anabaena sp. PCC 7120 possess an intact but partially degenerated gene cluster encoding gas vesicles. Bmc Microbiol. 2020 20 110 110 6L8E 32845304 Crystal structure of heterohexameric YoeB-YefM complex bound to 26bp-DNA 2019-11-06 2020-09-02 Xue, L.,Yue, J.,Ke, J.,Khan, M.H.,Wen, W.,Sun, B.,Zhu, Z.,Niu, L. Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system. Nucleic Acids Res. 2020 48 10527 10541 6M11 32830849 Crystal structure of Rnase L in complex with Sunitinib 2020-02-24 2020-09-02 Tang, J.,Wang, Y.,Zhou, H.,Ye, Y.,Talukdar, M.,Fu, Z.,Liu, Z.,Li, J.,Neculai, D.,Gao, J.,Huang, H. Sunitinib inhibits RNase L by destabilizing its active dimer conformation. Biochem.J. 2020 477 3387 3399 6M12 32830849 Crystal Structure of Rnase L in complex with SU11652 2020-02-24 2020-09-02 Tang, J.,Wang, Y.,Zhou, H.,Ye, Y.,Talukdar, M.,Fu, Z.,Liu, Z.,Li, J.,Neculai, D.,Gao, J.,Huang, H. Sunitinib inhibits RNase L by destabilizing its active dimer conformation. Biochem.J. 2020 477 3387 3399 6M13 32830849 Crystal structure of Rnase L in complex with Toceranib 2020-02-24 2020-09-02 Tang, J.,Wang, Y.,Zhou, H.,Ye, Y.,Talukdar, M.,Fu, Z.,Liu, Z.,Li, J.,Neculai, D.,Gao, J.,Huang, H. Sunitinib inhibits RNase L by destabilizing its active dimer conformation. Biochem.J. 2020 477 3387 3399 6M1J 32787097 The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12x 2020-02-26 2020-09-02 Hu, Y.,Shi, H.,Zhou, M.,Ren, Q.,Zhu, W.,Zhang, W.,Zhang, Z.,Zhou, C.,Liu, Y.,Ding, X.,Shen, H.C.,Yan, S.F.,Dey, F.,Wu, W.,Zhai, G.,Zhou, Z.,Xu, Z.,Ji, Y.,Lv, H.,Jiang, T.,Wang, W.,Xu, Y.,Vercruysse, M.,Yao, X.,Mao, Y.,Yu, X.,Bradley, K.,Tan, X. Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. J.Med.Chem. 2020 63 9623 9649 6M1S 32787097 The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12o 2020-02-26 2020-09-02 Hu, Y.,Shi, H.,Zhou, M.,Ren, Q.,Zhu, W.,Zhang, W.,Zhang, Z.,Zhou, C.,Liu, Y.,Ding, X.,Shen, H.C.,Yan, S.F.,Dey, F.,Wu, W.,Zhai, G.,Zhou, Z.,Xu, Z.,Ji, Y.,Lv, H.,Jiang, T.,Wang, W.,Xu, Y.,Vercruysse, M.,Yao, X.,Mao, Y.,Yu, X.,Bradley, K.,Tan, X. Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. J.Med.Chem. 2020 63 9623 9649 7BV6 32817423 Crystal structure of the autophagic STX17/SNAP29/VAMP8 SNARE complex 2020-04-09 2020-09-02 Li, Y.,Cheng, X.,Li, M.,Wang, Y.,Fu, T.,Zhou, Z.,Wang, Y.,Gong, X.,Xu, X.,Liu, J.,Pan, L. Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. Proc.Natl.Acad.Sci.USA 2020 117 21391 21402 7C2Q 32880863 The crystal structure of COVID-19 main protease in the apo state 2020-05-08 2020-09-02 Zhou, X.,Zhong, F.,Lin, C.,Hu, X.,Zhang, Y.,Xiong, B.,Yin, X.,Fu, J.,He, W.,Duan, J.,Fu, Y.,Zhou, H.,McCormick, P.J.,Wang, Q.,Li, J.,Zhang, J. Structure of SARS-CoV-2 main protease in the apo state. Sci China Life Sci 2021 64 656 659 7C2Y The crystal structure of COVID-2019 main protease in the apo state 2020-05-10 2020-09-02 Zhou, X.L.,Zhong, F.L.,Lin, C.,Zhou, H.,Hu, X.H.,Wang, Q.S.,Li, J.,Zhang, J. COVID-2019 main protease in the apo state To Be Published 0 0 0 0 7CJD 32895623 Crystal structure of the SARS-CoV-2 PLpro C111S mutant 2020-07-10 2020-09-02 Gao, X.,Qin, B.,Chen, P.,Zhu, K.,Hou, P.,Wojdyla, J.A.,Wang, M.,Cui, S. Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B 2021 11 237 245 7CMD 32895623 Crystal structure of the SARS-CoV-2 PLpro with GRL0617 2020-07-27 2020-09-02 Gao, X.,Qin, B.,Chen, P.,Zhu, K.,Hou, P.,Wojdyla, J.A.,Wang, M.,Cui, S. Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B 2021 11 237 245 6KVE 33404235 Crystal structure of a GH28 endo-polygalacturonase from Talaromyces leycettanus JCM 12802 2019-09-04 2020-09-09 Tu, T.,Wang, Z.,Luo, Y.,Li, Y.,Su, X.,Wang, Y.,Zhang, J.,Rouvinen, J.,Yao, B.,Hakulinen, N.,Luo, H. Structural Insights into the Mechanisms Underlying the Kinetic Stability of GH28 Endo-Polygalacturonase. J.Agric.Food Chem. 2021 69 815 823 6KVH 33404235 The mutant crystal structure of endo-polygalacturonase (T284A) from Talaromyces leycettanus JCM 12802 2019-09-04 2020-09-09 Tu, T.,Wang, Z.,Luo, Y.,Li, Y.,Su, X.,Wang, Y.,Zhang, J.,Rouvinen, J.,Yao, B.,Hakulinen, N.,Luo, H. Structural Insights into the Mechanisms Underlying the Kinetic Stability of GH28 Endo-Polygalacturonase. J.Agric.Food Chem. 2021 69 815 823 6KW0 The structure of EanB/Y353F-Cys412-persulfide in tetrahedral intermediate state with ergothioneine 2019-09-05 2020-09-09 Wu, L.,Liu, P.H.,Zhou, J.H. The structure of EanB/Y353F-Cys412-persulfide in tetrahedral intermediate state with ergothioneine To Be Published 0 0 0 0 6KW6 Crystal Structure of cytidine deaminase from Streptomyces noursei 2019-09-06 2020-09-09 Xie, T.,Liu, Z.C.,Wang, G.G. Crystal Structure of cytidine deaminase from Streptomyces noursei To Be Published 0 0 0 0 6KWK 33717070 Crystal structure of pSLA-1*0401 complex with FMDV-derived epitope MTAHITVPY 2019-09-07 2020-09-09 Wei, X.,Wang, S.,Li, Z.,Li, Z.,Qu, Z.,Wang, S.,Zou, B.,Liang, R.,Xia, C.,Zhang, N. Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism. Front Immunol 2021 12 592447 592447 6KWL 33717070 Crystal structure of pSLA-1*0401(R156A) complex with FMDV-derived epitope MTAHITVPY 2019-09-07 2020-09-09 Wei, X.,Wang, S.,Li, Z.,Li, Z.,Qu, Z.,Wang, S.,Zou, B.,Liang, R.,Xia, C.,Zhang, N. Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism. Front Immunol 2021 12 592447 592447 7C9O 32843433 Crystal structure of DNA-bound CCT/NF-YB/YC complex (HD1CCT/GHD8/OsNF-YC2) 2020-06-06 2020-09-09 Shen, C.,Liu, H.,Guan, Z.,Yan, J.,Zheng, T.,Yan, W.,Wu, C.,Zhang, Q.,Yin, P.,Xing, Y. Structural Insight into DNA Recognition by CCT/NF-YB/YC Complexes in Plant Photoperiodic Flowering. Plant Cell 2020 32 3469 3484 7C9P 32843433 Crystal structure of rice histone-fold dimer GHD8/OsNF-YC2 2020-06-06 2020-09-09 Shen, C.,Liu, H.,Guan, Z.,Yan, J.,Zheng, T.,Yan, W.,Wu, C.,Zhang, Q.,Yin, P.,Xing, Y. Structural Insight into DNA Recognition by CCT/NF-YB/YC Complexes in Plant Photoperiodic Flowering. Plant Cell 2020 32 3469 3484 7CCG 32828313 Crystal structure of ClA1, a kind of a chlorinase from soil bacteria 2020-06-17 2020-09-09 Miao, Y.,Yu, J.,Ouyang, Z.,Sun, H.,Li, Y. Crystal structure of ClA1, a type of chlorinase from soil bacteria. Biochem.Biophys.Res.Commun. 2020 530 42 46 6KXG 33083005 Crystal structure of caspase-11-CARD 2019-09-11 2020-09-16 Liu, M.,Zhou, K.,Xu, Z.,Ma, H.,Cao, X.,Yin, X.,Zeng, W.,Zahid, A.,Fu, S.,Ni, K.,Ye, X.,Zhou, Y.,Bai, L.,Zhou, R.,Jin, T. Crystal structure of caspase-11 CARD provides insights into caspase-11 activation. Cell Discov 2020 6 70 70 6KXK BON1 2019-09-12 2020-09-16 Wang, Q.C.,Jiang, M.Q.,Isupov, M.N.,Sun, L.F.,Wu, Y.K. Crystal Structure of an Arabidopsis Copine providing insights into this protein family To be published 0 0 0 0 6KXR 33004437 Crystal structure of wild type Alp1U from the biosynthesis of kinamycins 2019-09-12 2020-09-16 Zhang, L.,De, B.C.,Zhang, W.,Mandi, A.,Fang, Z.,Yang, C.,Zhu, Y.,Kurtan, T.,Zhang, C. Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha / beta-fold epoxide hydrolase Alp1U. J.Biol.Chem. 2020 295 16987 16997 6KXU BON1 2019-09-12 2020-09-16 Wang, Q.C.,Jiang, M.Q.,Isupov, M.N.,Sun, L.F.,Wu, Y.K. Crystal Structure of an Arabidopsis Copine providing insights into this protein family To be published 0 0 0 0 6LHE 33067430 Crystal Structure of Gold-bound NDM-1 2019-12-07 2020-09-16 Sun, H.,Zhang, Q.,Wang, R.,Wang, H.,Wong, Y.T.,Wang, M.,Hao, Q.,Yan, A.,Kao, R.Y.,Ho, P.L.,Li, H. Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin. Nat Commun 2020 11 5263 5263 6LI4 33067430 Crystal structure of MCR-1-S 2019-12-10 2020-09-16 Sun, H.,Zhang, Q.,Wang, R.,Wang, H.,Wong, Y.T.,Wang, M.,Hao, Q.,Yan, A.,Kao, R.Y.,Ho, P.L.,Li, H. Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin. Nat Commun 2020 11 5263 5263 6LI5 33067430 Crystal structure of apo-MCR-1-S 2019-12-10 2020-09-16 Sun, H.,Zhang, Q.,Wang, R.,Wang, H.,Wong, Y.T.,Wang, M.,Hao, Q.,Yan, A.,Kao, R.Y.,Ho, P.L.,Li, H. Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin. Nat Commun 2020 11 5263 5263 6LI6 33067430 Crystal structure of MCR-1-S treated by Au(PEt3)Cl 2019-12-10 2020-09-16 Sun, H.,Zhang, Q.,Wang, R.,Wang, H.,Wong, Y.T.,Wang, M.,Hao, Q.,Yan, A.,Kao, R.Y.,Ho, P.L.,Li, H. Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin. Nat Commun 2020 11 5263 5263 6LIY 32860438 SeMet CRL Protein of Arabidopsis 2019-12-13 2020-09-16 Wang, F.,Fang, J.,Guan, K.,Luo, S.,Dogra, V.,Li, B.,Ma, D.,Zhao, X.,Lee, K.P.,Sun, P.,Xin, J.,Liu, T.,Xing, W.,Kim, C. The Arabidopsis CRUMPLED LEAF protein, a homolog of the cyanobacterial bilin lyase, retains the bilin-binding pocket for a yet unknown function. Plant J. 2020 104 964 978 7CH5 32970990 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab 2020-07-05 2020-09-16 Du, S.,Cao, Y.,Zhu, Q.,Yu, P.,Qi, F.,Wang, G.,Du, X.,Bao, L.,Deng, W.,Zhu, H.,Liu, J.,Nie, J.,Zheng, Y.,Liang, H.,Liu, R.,Gong, S.,Xu, H.,Yisimayi, A.,Lv, Q.,Wang, B.,He, R.,Han, Y.,Zhao, W.,Bai, Y.,Qu, Y.,Gao, X.,Ji, C.,Wang, Q.,Gao, N.,Huang, W.,Wang, Y.,Xie, X.S.,Su, X.D.,Xiao, J.,Qin, C. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell 2020 183 1013 0 7CHB 32970990 Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab 2020-07-05 2020-09-16 Du, S.,Cao, Y.,Zhu, Q.,Yu, P.,Qi, F.,Wang, G.,Du, X.,Bao, L.,Deng, W.,Zhu, H.,Liu, J.,Nie, J.,Zheng, Y.,Liang, H.,Liu, R.,Gong, S.,Xu, H.,Yisimayi, A.,Lv, Q.,Wang, B.,He, R.,Han, Y.,Zhao, W.,Bai, Y.,Qu, Y.,Gao, X.,Ji, C.,Wang, Q.,Gao, N.,Huang, W.,Wang, Y.,Xie, X.S.,Su, X.D.,Xiao, J.,Qin, C. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell 2020 183 1013 0 7CHC 32970990 Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab and BD-368-2 Fab 2020-07-05 2020-09-16 Du, S.,Cao, Y.,Zhu, Q.,Yu, P.,Qi, F.,Wang, G.,Du, X.,Bao, L.,Deng, W.,Zhu, H.,Liu, J.,Nie, J.,Zheng, Y.,Liang, H.,Liu, R.,Gong, S.,Xu, H.,Yisimayi, A.,Lv, Q.,Wang, B.,He, R.,Han, Y.,Zhao, W.,Bai, Y.,Qu, Y.,Gao, X.,Ji, C.,Wang, Q.,Gao, N.,Huang, W.,Wang, Y.,Xie, X.S.,Su, X.D.,Xiao, J.,Qin, C. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell 2020 183 1013 0 7CHE 32970990 Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab and BD-368-2 Fab 2020-07-05 2020-09-16 Du, S.,Cao, Y.,Zhu, Q.,Yu, P.,Qi, F.,Wang, G.,Du, X.,Bao, L.,Deng, W.,Zhu, H.,Liu, J.,Nie, J.,Zheng, Y.,Liang, H.,Liu, R.,Gong, S.,Xu, H.,Yisimayi, A.,Lv, Q.,Wang, B.,He, R.,Han, Y.,Zhao, W.,Bai, Y.,Qu, Y.,Gao, X.,Ji, C.,Wang, Q.,Gao, N.,Huang, W.,Wang, Y.,Xie, X.S.,Su, X.D.,Xiao, J.,Qin, C. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell 2020 183 1013 0 7CHF 32970990 Crystal structure of the SARS-CoV-2 RBD in complex with BD-604 Fab and BD-368-2 Fab 2020-07-05 2020-09-16 Du, S.,Cao, Y.,Zhu, Q.,Yu, P.,Qi, F.,Wang, G.,Du, X.,Bao, L.,Deng, W.,Zhu, H.,Liu, J.,Nie, J.,Zheng, Y.,Liang, H.,Liu, R.,Gong, S.,Xu, H.,Yisimayi, A.,Lv, Q.,Wang, B.,He, R.,Han, Y.,Zhao, W.,Bai, Y.,Qu, Y.,Gao, X.,Ji, C.,Wang, Q.,Gao, N.,Huang, W.,Wang, Y.,Xie, X.S.,Su, X.D.,Xiao, J.,Qin, C. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell 2020 183 1013 0 6KYF 33049228 Crystal structure of an anti-CRISPR protein 2019-09-18 2020-09-23 Niu, Y.,Yang, L.,Gao, T.,Dong, C.,Zhang, B.,Yin, P.,Hopp, A.K.,Li, D.,Gan, R.,Wang, H.,Liu, X.,Cao, X.,Xie, Y.,Meng, X.,Deng, H.,Zhang, X.,Ren, J.,Hottiger, M.O.,Chen, Z.,Zhang, Y.,Liu, X.,Feng, Y. A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation. Mol.Cell 2020 80 512 0 6KZK 31682837 Structure of alginate lyase Aly36B mutant K143A/M171A in complex with alginate trisaccharide 2019-09-24 2020-09-23 Dong, F.,Xu, F.,Chen, X.L.,Li, P.Y.,Li, C.Y.,Li, F.C.,Chen, Y.,Wang, P.,Zhang, Y.Z. Alginate Lyase Aly36B is a New Bacterial Member of the Polysaccharide Lyase Family 36 and Catalyzes by a Novel Mechanism With Lysine as Both the Catalytic Base and Catalytic Acid. J.Mol.Biol. 2019 431 4897 4909 7C5F 32880588 Crystal Structure of Glyceraldehyde-3-phosphate dehydrogenase1 from Escherichia coli at 1.88 Angstrom resolution 2020-05-20 2020-09-23 Zhang, L.,Liu, M.R.,Yao, Y.C.,Bostrom, I.K.,Wang, Y.D.,Chen, A.Q.,Li, J.X.,Gu, S.H.,Ji, C.N. Characterization and structure of glyceraldehyde-3-phosphate dehydrogenase type 1 from Escherichia coli. Acta Crystallogr.,Sect.F 2020 76 406 413 7CGC 34123202 Silver-bound E. coli Malate dehydrogenase (C113 and C251) 2020-07-01 2020-09-23 Wang, H.,Yang, X.,Wang, M.,Hu, M.,Xu, X.,Yan, A.,Hao, Q.,Li, H.,Sun, H. Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chem Sci 2020 11 11714 11719 7CGD 34123202 Silver-bound E.coli malate dehydrogenase 2020-07-01 2020-09-23 Wang, H.,Yang, X.,Wang, M.,Hu, M.,Xu, X.,Yan, A.,Hao, Q.,Li, H.,Sun, H. Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chem Sci 2020 11 11714 11719 7D1O 33542181 Crystal structure of SARS-Cov-2 main protease with narlaprevir 2020-09-15 2020-09-23 Bai, Y.,Ye, F.,Feng, Y.,Liao, H.,Song, H.,Qi, J.,Gao, G.F.,Tan, W.,Fu, L.,Shi, Y. Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir. Signal Transduct Target Ther 2021 6 51 51 6KZQ 33764618 structure of PTP-MEG2 and NSF-pY83 peptide complex 2019-09-25 2020-09-30 Xu, Y.F.,Chen, X.,Yang, Z.,Xiao, P.,Liu, C.H.,Li, K.S.,Yang, X.Z.,Wang, Y.J.,Zhu, Z.L.,Xu, Z.G.,Zhang, S.,Wang, C.,Song, Y.C.,Zhao, W.D.,Wang, C.H.,Ji, Z.L.,Zhang, Z.Y.,Cui, M.,Sun, J.P.,Yu, X. PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Rep. 2021 22 0 0 6L03 33764618 structure of PTP-MEG2 and MUNC18-1-pY145 peptide complex 2019-09-25 2020-09-30 Xu, Y.F.,Chen, X.,Yang, Z.,Xiao, P.,Liu, C.H.,Li, K.S.,Yang, X.Z.,Wang, Y.J.,Zhu, Z.L.,Xu, Z.G.,Zhang, S.,Wang, C.,Song, Y.C.,Zhao, W.D.,Wang, C.H.,Ji, Z.L.,Zhang, Z.Y.,Cui, M.,Sun, J.P.,Yu, X. PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Rep. 2021 22 0 0 6L1E Crystal structure of middle domain of hSSRP1 2019-09-29 2020-09-30 Li, H.Y.,Hu, T.T.,Dou, Y.S.,Su, D. Crystal structure of middle domain of hSSRP1 To Be Published 0 0 0 0 6M6U 33045733 Crystal structure the toxin-antitoxin MntA-HpeT mutant-D39ED41E 2020-03-16 2020-09-30 Yao, J.,Zhen, X.,Tang, K.,Liu, T.,Xu, X.,Chen, Z.,Guo, Y.,Liu, X.,Wood, T.K.,Ouyang, S.,Wang, X. Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res. 2020 48 11054 11067 6M6V 33045733 Crystal structure the toxin-antitoxin MntA-HepT 2020-03-16 2020-09-30 Yao, J.,Zhen, X.,Tang, K.,Liu, T.,Xu, X.,Chen, Z.,Guo, Y.,Liu, X.,Wood, T.K.,Ouyang, S.,Wang, X. Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res. 2020 48 11054 11067 6M6W 33045733 Crystal structure the toxin-antitoxin MntA-HpeT mutant-Y104A 2020-03-16 2020-09-30 Yao, J.,Zhen, X.,Tang, K.,Liu, T.,Xu, X.,Chen, Z.,Guo, Y.,Liu, X.,Wood, T.K.,Ouyang, S.,Wang, X. Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res. 2020 48 11054 11067 7BT5 33053158 Crystal structure of plasmodium LysRS complexing with an antitumor compound 2020-03-31 2020-09-30 Zhou, J.,Huang, Z.,Zheng, L.,Hei, Z.,Wang, Z.,Yu, B.,Jiang, L.,Wang, J.,Fang, P. Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor. Nucleic Acids Res. 2020 48 11566 11576 7BXO 33045733 Crystal structure of the toxin-antitoxin with AMP-PNP 2020-04-20 2020-09-30 Yao, J.,Zhen, X.,Tang, K.,Liu, T.,Xu, X.,Chen, Z.,Guo, Y.,Liu, X.,Wood, T.K.,Ouyang, S.,Wang, X. Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic Acids Res. 2020 48 11054 11067 6LQN 33106493 EBV tegument protein BBRF2 2020-01-14 2020-10-07 He, H.P.,Luo, M.,Cao, Y.L.,Lin, Y.X.,Zhang, H.,Zhang, X.,Ou, J.Y.,Yu, B.,Chen, X.,Xu, M.,Feng, L.,Zeng, M.S.,Zeng, Y.X.,Gao, S. Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. Nat Commun 2020 11 5405 5405 6LQO 33106493 EBV tegument protein BBRF2/BSRF1 complex 2020-01-14 2020-10-07 He, H.P.,Luo, M.,Cao, Y.L.,Lin, Y.X.,Zhang, H.,Zhang, X.,Ou, J.Y.,Yu, B.,Chen, X.,Xu, M.,Feng, L.,Zeng, M.S.,Zeng, Y.X.,Gao, S. Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. Nat Commun 2020 11 5405 5405 6W65 32679093 Human PARP16 in complex with RBN010860 2020-03-16 2020-10-07 Wigle, T.J.,Blackwell, D.J.,Schenkel, L.B.,Ren, Y.,Church, W.D.,Desai, H.J.,Swinger, K.K.,Santospago, A.G.,Majer, C.R.,Lu, A.Z.,Niepel, M.,Perl, N.R.,Vasbinder, M.M.,Keilhack, H.,Kuntz, K.W. In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement. Cell Chem Biol 2020 27 877 0 7C8F 32967968 Structure of alginate lyase AlyC3 in complex with dimannuronate(2M) 2020-05-30 2020-10-07 Xu, F.,Chen, X.L.,Sun, X.H.,Dong, F.,Li, C.Y.,Li, P.Y.,Ding, H.,Chen, Y.,Zhang, Y.Z.,Wang, P. Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic. J.Biol.Chem. 2020 295 16380 16392 7C8G 32967968 Structure of alginate lyase AlyC3 2020-05-30 2020-10-07 Xu, F.,Chen, X.L.,Sun, X.H.,Dong, F.,Li, C.Y.,Li, P.Y.,Ding, H.,Chen, Y.,Zhang, Y.Z.,Wang, P. Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic. J.Biol.Chem. 2020 295 16380 16392 7CBI 32980741 Crystal structure of threonyl-tRNA synthetase (ThrRS) from Salmonella enterica in complex with an inhibitor 2020-06-12 2020-10-07 Guo, J.,Chen, B.,Yu, Y.,Cheng, B.,Ju, Y.,Tang, J.,Cai, Z.,Gu, Q.,Xu, J.,Zhou, H. Structure-guided optimization and mechanistic study of a class of quinazolinone-threonine hybrids as antibacterial ThrRS inhibitors. Eur.J.Med.Chem. 2020 207 112848 112848 6LGT 32286826 Complex structure of HPPD with an inhibitor Y16542 2019-12-05 2020-10-14 He, B.,Wu, F.X.,Yu, L.K.,Wu, L.,Chen, Q.,Hao, G.F.,Yang, W.C.,Lin, H.Y.,Yang, G.F. Discovery of Novel Pyrazole-Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. J.Agric.Food Chem. 2020 68 5059 5067 7BQL 32999480 The crystal structure of PdxI complex with the Alder-ene adduct 2020-03-24 2020-10-14 Ohashi, M.,Jamieson, C.S.,Cai, Y.,Tan, D.,Kanayama, D.,Tang, M.C.,Anthony, S.M.,Chari, J.V.,Barber, J.S.,Picazo, E.,Kakule, T.B.,Cao, S.,Garg, N.K.,Zhou, J.,Houk, K.N.,Tang, Y. An enzymatic Alder-ene reaction. Nature 2020 586 64 69 7BQL 32999480 The crystal structure of PdxI complex with the Alder-ene adduct 2020-03-24 2020-10-14 Ohashi, M.,Jamieson, C.S.,Cai, Y.,Tan, D.,Kanayama, D.,Tang, M.C.,Anthony, S.M.,Chari, J.V.,Barber, J.S.,Picazo, E.,Kakule, T.B.,Cao, S.,Garg, N.K.,Zhou, J.,Houk, K.N.,Tang, Y. An enzymatic Alder-ene reaction. Nature 2020 586 64 69 7BQZ 32994220 Crystal Structure of Spindlin1 bound to H3(K4me3-K9me3) peptide 2020-03-26 2020-10-14 Zhao, F.,Liu, Y.,Su, X.,Lee, J.E.,Song, Y.,Wang, D.,Ge, K.,Gao, J.,Zhang, M.Q.,Li, H. Molecular basis for histone H3 ""K4me3-K9me3/2"" methylation pattern readout by Spindlin1. J.Biol.Chem. 2020 295 16877 16887 7BU9 32994220 Crystal Structure of Spindlin1-H3(K4me3-K9me2) complex 2020-04-05 2020-10-14 Zhao, F.,Liu, Y.,Su, X.,Lee, J.E.,Song, Y.,Wang, D.,Ge, K.,Gao, J.,Zhang, M.Q.,Li, H. Molecular basis for histone H3 ""K4me3-K9me3/2"" methylation pattern readout by Spindlin1. J.Biol.Chem. 2020 295 16877 16887 6KF8 OsACBP2 in complex with C18:3-CoA 2019-07-06 2020-10-21 Jin, J.,Chye, M.L. OsACBP2 in complex with C18:3-CoA To Be Published 0 0 0 0 6L4K Human serum albumin-Palmitic acid-Cu compound 2019-10-17 2020-10-21 Zhang, Z.L. A novel brain-tumor-inhibiting copper(II) compound based on a human serum albumin-cell penetrating peptide conjugate To Be Published 0 0 0 0 6L4L Crystal structure of S. aureus CntK in inactive state 2019-10-18 2020-10-21 Ju, Y.,Luo, S.,Zhou, H. Crystal structure of S. aureus CntK in inactive state To Be Published 0 0 0 0 6LBF 33398168 Crystal structure of FEM1B 2019-11-14 2020-10-21 Chen, X.,Liao, S.,Makaros, Y.,Guo, Q.,Zhu, Z.,Krizelman, R.,Dahan, K.,Tu, X.,Yao, X.,Koren, I.,Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol. 2021 17 254 262 6LBG 33398168 Structure of OR51B2 bound FEM1C 2019-11-14 2020-10-21 Chen, X.,Liao, S.,Makaros, Y.,Guo, Q.,Zhu, Z.,Krizelman, R.,Dahan, K.,Tu, X.,Yao, X.,Koren, I.,Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol. 2021 17 254 262 6LDP 33398168 Structure of CDK5R1-bound FEM1C 2019-11-22 2020-10-21 Chen, X.,Liao, S.,Makaros, Y.,Guo, Q.,Zhu, Z.,Krizelman, R.,Dahan, K.,Tu, X.,Yao, X.,Koren, I.,Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol. 2021 17 254 262 6LE6 33398168 Structure of LNLPTQGRAR bound FEM1C 2019-11-24 2020-10-21 Chen, X.,Liao, S.,Makaros, Y.,Guo, Q.,Zhu, Z.,Krizelman, R.,Dahan, K.,Tu, X.,Yao, X.,Koren, I.,Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol. 2021 17 254 262 6LEN 33398168 Structure of NS11 bound FEM1C 2019-11-25 2020-10-21 Chen, X.,Liao, S.,Makaros, Y.,Guo, Q.,Zhu, Z.,Krizelman, R.,Dahan, K.,Tu, X.,Yao, X.,Koren, I.,Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol. 2021 17 254 262 6LEY 33398168 Structure of Sil1G bound FEM1C 2019-11-27 2020-10-21 Chen, X.,Liao, S.,Makaros, Y.,Guo, Q.,Zhu, Z.,Krizelman, R.,Dahan, K.,Tu, X.,Yao, X.,Koren, I.,Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol. 2021 17 254 262 6LF0 33398168 Structure of FEM1C 2019-11-27 2020-10-21 Chen, X.,Liao, S.,Makaros, Y.,Guo, Q.,Zhu, Z.,Krizelman, R.,Dahan, K.,Tu, X.,Yao, X.,Koren, I.,Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol. 2021 17 254 262 7BTN 33036755 Crystal structure of human inorganic pyrophosphatase with metal ions 2020-04-02 2020-10-21 Hu, F.,Huang, Z.,Zheng, S.,Wu, Q.,Chen, Y.,Lin, H.,Huang, W.,Li, L. Structural and biochemical characterization of inorganic pyrophosphatase from Homo sapiens. Biochem.Biophys.Res.Commun. 2020 533 1115 1121 7CMO 33036755 Crystal structure of human inorganic pyrophosphatase 2020-07-28 2020-10-21 Hu, F.,Huang, Z.,Zheng, S.,Wu, Q.,Chen, Y.,Lin, H.,Huang, W.,Li, L. Structural and biochemical characterization of inorganic pyrophosphatase from Homo sapiens. Biochem.Biophys.Res.Commun. 2020 533 1115 1121 7CZF 33235207 Crystal structure of Kaposi Sarcoma associated herpesvirus (KSHV ) gHgL in complex with the ligand binding domian (LBD) of EphA2 2020-09-08 2020-10-21 Su, C.,Wu, L.,Chai, Y.,Qi, J.,Tan, S.,Gao, G.F.,Song, H.,Yan, J. Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses. Nat Commun 2020 11 5964 5964 6L5Z 33306911 Crystal strucutre of AF9 YEATS domain in complex with a cyclopeptide inhibitor 2019-10-25 2020-10-28 Jiang, Y.,Chen, G.,Li, X.M.,Liu, S.,Tian, G.,Li, Y.,Li, X.,Li, H.,Li, X.D. Selective Targeting of AF9 YEATS Domain by Cyclopeptide Inhibitors with Preorganized Conformation. J.Am.Chem.Soc. 2020 142 21450 21459 6LK3 The Functional Characterization and Crystal Structure of Type II Peptidyl Carrier Protein ColA1a in Collismycins Biosynthesis 2019-12-18 2020-10-28 Ma, X.Y.,Wang, G.Y.,Liu, T.,Chi, C.B.,Zhang, Z.Y.,Yang, D.H.,Liu, W.,Ma, M. The functional characterization and crystal structure of type II peptidyl carrier protein ColA1a in collismycins biosynthesis. Chin.J.Chem. 2020 38 963 969 6LTU 33067443 Crystal structure of Cas12i2 ternary complex with double Mg2+ bound in catalytic pocket 2020-01-23 2020-10-28 Huang, X.,Sun, W.,Cheng, Z.,Chen, M.,Li, X.,Wang, J.,Sheng, G.,Gong, W.,Wang, Y. Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun 2020 11 5241 5241 6LU0 33067443 Crystal structure of Cas12i2 ternary complex with 12 nt spacer 2020-01-24 2020-10-28 Huang, X.,Sun, W.,Cheng, Z.,Chen, M.,Li, X.,Wang, J.,Sheng, G.,Gong, W.,Wang, Y. Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun 2020 11 5241 5241 7CBY 33058871 Structure of FOXG1 DNA binding domain bound to DBE2 DNA site 2020-06-15 2020-10-28 Dai, S.,Li, J.,Zhang, H.,Chen, X.,Guo, M.,Chen, Z.,Chen, Y. Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations. J.Mol.Biol. 2020 432 6146 6156 7D1M 32887884 CRYSTAL STRUCTURE OF THE SARS-CoV-2 MAIN PROTEASE COMPLEXED WITH GC376 2020-09-14 2020-10-28 Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F. Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun 2020 11 4417 4417 6JZB 32621942 Structural characterization of DnaJ from Streptococcus pneumonia presents a new tetramer of Hsp40 family 2019-04-30 2020-11-04 Zhu, M.,Ou, D.,Khan, M.H.,Zhao, S.,Zhu, Z.,Niu, L. Structural insights into the formation of oligomeric state by a type I Hsp40 chaperone. Biochimie 2020 176 45 51 6L65 Sirtuin 2 protein with H3K18 myristoylated peptide 2019-10-28 2020-11-04 Chen, L.F. Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published 0 0 0 0 6L66 Sirtuin 2 protein with H3K18 myristoylated peptide and intact NAD molecule 2019-10-28 2020-11-04 Chen, L.F. Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published 0 0 0 0 6VND 33082276 Quaternary Complex of human dihydroorotate dehydrogenase (DHODH) with flavin mononucleotide (FMN), orotic acid and AG-636 2020-01-29 2020-11-04 McDonald, G.,Chubukov, V.,Coco, J.,Truskowski, K.,Narayanaswamy, R.,Choe, S.,Steadman, M.,Artin, E.,Padyana, A.K.,Jin, L.,Ronseaux, S.,Locuson, C.,Fan, Z.P.,Erdmann, T.,Mann, A.,Hayes, S.,Fletcher, M.,Nellore, K.,Rao, S.S.,Subramanya, H.,Reddy, K.S.,Panigrahi, S.K.,Antony, T.,Gopinath, S.,Sui, Z.,Nagaraja, N.,Dang, L.,Lenz, G.,Hurov, J.,Biller, S.A.,Murtie, J.,Marks, K.M.,Ulanet, D.B. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol.Cancer Ther. 2020 19 2502 2515 7D6H 33979649 Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant 2020-09-30 2020-11-04 Shan, H.,Liu, J.,Shen, J.,Dai, J.,Xu, G.,Lu, K.,Han, C.,Wang, Y.,Xu, X.,Tong, Y.,Xiang, H.,Ai, Z.,Zhuang, G.,Hu, J.,Zhang, Z.,Li, Y.,Pan, L.,Tan, L. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol 2021 28 855 0 6L8N 33436623 Crystal structure of the K. lactis Rad5 2019-11-06 2020-11-11 Shen, M.,Dhingra, N.,Wang, Q.,Cheng, C.,Zhu, S.,Tian, X.,Yu, J.,Gong, X.,Li, X.,Zhang, H.,Xu, X.,Zhai, L.,Xie, M.,Gao, Y.,Deng, H.,He, Y.,Niu, H.,Zhao, X.,Xiang, S. Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun 2021 12 321 321 6L8O 33436623 Crystal structure of the K. lactis Rad5 (Hg-derivative) 2019-11-06 2020-11-11 Shen, M.,Dhingra, N.,Wang, Q.,Cheng, C.,Zhu, S.,Tian, X.,Yu, J.,Gong, X.,Li, X.,Zhang, H.,Xu, X.,Zhai, L.,Xie, M.,Gao, Y.,Deng, H.,He, Y.,Niu, H.,Zhao, X.,Xiang, S. Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun 2021 12 321 321 6LJJ 33139328 Swine dUTPase in complex with alpha,beta-iminodUTP and magnesium ion 2019-12-16 2020-11-11 Liang, R.,Wang, G.,Zhang, D.,Ye, G.,Li, M.,Shi, Y.,Shi, J.,Chen, H.,Peng, G. Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development. J.Biol.Chem. 2020 296 100015 100015 6LJO 33139328 African swine fever virus dUTPase 2019-12-17 2020-11-11 Liang, R.,Wang, G.,Zhang, D.,Ye, G.,Li, M.,Shi, Y.,Shi, J.,Chen, H.,Peng, G. Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development. J.Biol.Chem. 2020 296 100015 100015 7BP2 33199628 Structural mechanism directing nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1) 2020-03-21 2020-11-11 Luo, Q.,Wang, B.,Wu, Z.,Jiang, W.,Wang, Y.,Du, K.,Zhou, N.,Zheng, L.,Gan, J.,Shen, W.H.,Ma, J.,Dong, A. NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proc.Natl.Acad.Sci.USA 2020 117 30391 30399 7BP4 33199628 Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1) 2020-03-21 2020-11-11 Luo, Q.,Wang, B.,Wu, Z.,Jiang, W.,Wang, Y.,Du, K.,Zhou, N.,Zheng, L.,Gan, J.,Shen, W.H.,Ma, J.,Dong, A. NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proc.Natl.Acad.Sci.USA 2020 117 30391 30399 7BP5 33199628 Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1) 2020-03-21 2020-11-11 Luo, Q.,Wang, B.,Wu, Z.,Jiang, W.,Wang, Y.,Du, K.,Zhou, N.,Zheng, L.,Gan, J.,Shen, W.H.,Ma, J.,Dong, A. NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proc.Natl.Acad.Sci.USA 2020 117 30391 30399 7BP6 33199628 Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1) 2020-03-21 2020-11-11 Luo, Q.,Wang, B.,Wu, Z.,Jiang, W.,Wang, Y.,Du, K.,Zhou, N.,Zheng, L.,Gan, J.,Shen, W.H.,Ma, J.,Dong, A. NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proc.Natl.Acad.Sci.USA 2020 117 30391 30399 7C7X 33199628 Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1) 2020-05-27 2020-11-11 Luo, Q.,Wang, B.,Wu, Z.,Jiang, W.,Wang, Y.,Du, K.,Zhou, N.,Zheng, L.,Gan, J.,Shen, W.H.,Ma, J.,Dong, A. NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proc.Natl.Acad.Sci.USA 2020 117 30391 30399 7CJF 33976198 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab 2020-07-10 2020-11-11 Guo, Y.,Huang, L.,Zhang, G.,Yao, Y.,Zhou, H.,Shen, S.,Shen, B.,Li, B.,Li, X.,Zhang, Q.,Chen, M.,Chen, D.,Wu, J.,Fu, D.,Zeng, X.,Feng, M.,Pi, C.,Wang, Y.,Zhou, X.,Lu, M.,Li, Y.,Fang, Y.,Lu, Y.Y.,Hu, X.,Wang, S.,Zhang, W.,Gao, G.,Adrian, F.,Wang, Q.,Yu, F.,Peng, Y.,Gabibov, A.G.,Min, J.,Wang, Y.,Huang, H.,Stepanov, A.,Zhang, W.,Cai, Y.,Liu, J.,Yuan, Z.,Zhang, C.,Lou, Z.,Deng, F.,Zhang, H.,Shan, C.,Schweizer, L.,Sun, K.,Rao, Z. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun 2021 12 2623 2623 6L9K 34074778 H2-Ld a1a2 complexed with A5 peptide 2019-11-10 2020-11-18 Wei, P.,Jordan, K.R.,Buhrman, J.D.,Lei, J.,Deng, H.,Marrack, P.,Dai, S.,Kappler, J.W.,Slansky, J.E.,Yin, L. Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer. Proc.Natl.Acad.Sci.USA 2021 118 0 0 6LIR 33305184 crystal structure of chicken TCR for 2.0 2019-12-12 2020-11-18 Zhang, L.,Liu, Y.,Meng, G.,Liang, R.,Zhang, B.,Xia, C. Structural and Biophysical Insights into the TCR alpha beta Complex in Chickens. Iscience 2020 23 101828 101828 6LPI 32538427 Crystal Structure of AHAS holo-enzyme 2020-01-10 2020-11-18 Zhang, Y.,Li, Y.,Liu, X.,Sun, J.,Li, X.,Lin, J.,Yang, X.,Xi, Z.,Shen, Y. Molecular architecture of the acetohydroxyacid synthase holoenzyme. Biochem.J. 2020 477 2439 2449 6LS6 33290558 Crystal Structure of YEATS domain of AF9 in complex with H3K9bz peptide 2020-01-17 2020-11-18 Ren, X.,Zhou, Y.,Xue, Z.,Hao, N.,Li, Y.,Guo, X.,Wang, D.,Shi, X.,Li, H. Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins. Nucleic Acids Res. 2021 49 114 126 6LSB 33290558 Crystal Structure of DPF domain of MOZ in complex with H3K14bz peptide 2020-01-17 2020-11-18 Ren, X.,Zhou, Y.,Xue, Z.,Hao, N.,Li, Y.,Guo, X.,Wang, D.,Shi, X.,Li, H. Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins. Nucleic Acids Res. 2021 49 114 126 6LSD 33290558 Crystal Structure of YEATS domain of human YEATS2 in complex with H3K27bz peptide 2020-01-17 2020-11-18 Ren, X.,Zhou, Y.,Xue, Z.,Hao, N.,Li, Y.,Guo, X.,Wang, D.,Shi, X.,Li, H. Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins. Nucleic Acids Res. 2021 49 114 126 7BU0 33136002 Crystal structure of a OTU deubiquitinase in complex with Ub-PA 2020-04-03 2020-11-18 Liu, S.,Jiwei, L.,Zhen, X.,Qiu, J.,Ouyang, S.,Luo, Z.Q. Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes. Elife 2020 9 0 0 7CDI 33431856 Crystal structure of SARS-CoV-2 antibody P2C-1F11 with RBD 2020-06-19 2020-11-18 Ge, J.,Wang, R.,Ju, B.,Zhang, Q.,Sun, J.,Chen, P.,Zhang, S.,Tian, Y.,Shan, S.,Cheng, L.,Zhou, B.,Song, S.,Zhao, J.,Wang, H.,Shi, X.,Ding, Q.,Liu, L.,Zhao, J.,Zhang, Z.,Wang, X.,Zhang, L. Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nat Commun 2021 12 250 250 7CDJ 33431856 Crystal structure of SARS-CoV-2 antibody P2C-1A3 with RBD 2020-06-19 2020-11-18 Ge, J.,Wang, R.,Ju, B.,Zhang, Q.,Sun, J.,Chen, P.,Zhang, S.,Tian, Y.,Shan, S.,Cheng, L.,Zhou, B.,Song, S.,Zhao, J.,Wang, H.,Shi, X.,Ding, Q.,Liu, L.,Zhao, J.,Zhang, Z.,Wang, X.,Zhang, L. Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nat Commun 2021 12 250 250 7CM1 33135677 Neuraminidase from the Wuhan Asiatic toad influenza virus 2020-07-23 2020-11-18 Li, L.,Dai, S.,Gao, G.F.,Wang, J. Lattice-translocation defects in specific crystals of the catalytic head domain of influenza neuraminidase. Acta Crystallogr D Struct Biol 2020 76 1057 1064 6LCU structure of maltooligosyltrehalose synthase from Arthrobacter ramosus 2019-11-20 2020-11-25 Chen, C.,Wu, J. structure of maltooligosyltrehalose synthase from Arthrobacter ramosus To Be Published 0 0 0 0 6LLX 33087132 Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma 2019-12-24 2020-11-25 Lei, K.,Gu, X.,Alvarado, A.G.,Du, Y.,Luo, S.,Ahn, E.H.,Kang, S.S.,Ji, B.,Liu, X.,Mao, H.,Fu, H.,Kornblum, H.I.,Jin, L.,Li, H.,Ye, K. Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma. J Hematol Oncol 2020 13 141 141 6LRU Marsupenaeus japonicus ferritin mutant (T158H) 2020-01-16 2020-11-25 Tan, X.,Chen, H.,Gu, C.,Zhang, J.,Zhang, T.,Wang, H.,Zhao, G. Converting histidine-induced 3D protein arrays in crystals into their 3D analogues in solution by metal coordination cross-linking. Commun Chem 2020 0 0 0 7C1L 33436600 Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant R148A in complex with C8-CoA 2020-05-05 2020-11-25 Zhong, L.,Diao, X.,Zhang, N.,Li, F.,Zhou, H.,Chen, H.,Bai, X.,Ren, X.,Zhang, Y.,Wu, D.,Bian, X. Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis. Nat Commun 2021 12 296 296 6LEW RVD HA specifically contacts 5mC through van der Waals interactions 2019-11-27 2020-12-02 Liu, L.,Yi, C. RVD HA specifically contacts 5mC through van der Waals interactions To Be Published 0 0 0 0 6LXI 33024040 Crystal structure of Z2B3 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) 2020-02-11 2020-12-02 Jiang, H.,Peng, W.,Qi, J.,Chai, Y.,Song, H.,Bi, Y.,Rijal, P.,Wang, H.,Oladejo, B.O.,Liu, J.,Shi, Y.,Gao, G.F.,Townsend, A.R.,Wu, Y. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. Mbio 2020 11 0 0 6LXJ 33024040 Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9) 2020-02-11 2020-12-02 Jiang, H.,Peng, W.,Qi, J.,Chai, Y.,Song, H.,Bi, Y.,Rijal, P.,Wang, H.,Oladejo, B.O.,Liu, J.,Shi, Y.,Gao, G.F.,Townsend, A.R.,Wu, Y. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. Mbio 2020 11 0 0 6LXK 33024040 Crystal structure of Z2B3 D102R Fab in complex with influenza virus neuraminidase from A/Serbia/NS-601/2014 (H1N1) 2020-02-11 2020-12-02 Jiang, H.,Peng, W.,Qi, J.,Chai, Y.,Song, H.,Bi, Y.,Rijal, P.,Wang, H.,Oladejo, B.O.,Liu, J.,Shi, Y.,Gao, G.F.,Townsend, A.R.,Wu, Y. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. Mbio 2020 11 0 0 7CDB 33436612 Structure of GABARAPL1 in complex with GABA(A) receptor gamma 2 2020-06-19 2020-12-02 Ye, J.,Zou, G.,Zhu, R.,Kong, C.,Miao, C.,Zhang, M.,Li, J.,Xiong, W.,Wang, C. Structural basis of GABARAP-mediated GABA A receptor trafficking and functions on GABAergic synaptic transmission. Nat Commun 2021 12 297 297 7D42 33121679 Structural basis of tropifexor as a potent and selective agonist for farnesoid X receptor 2020-09-22 2020-12-02 Jiang, L.,Xiao, D.,Li, Y.,Dai, S.,Qu, L.,Chen, X.,Guo, M.,Wei, H.,Chen, Y. Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor. Biochem.Biophys.Res.Commun. 2021 534 1047 1052 7D8U 33268516 Crystal structure of the C-terminal domain of pNP868R from African swine fever virus 2020-10-10 2020-12-02 Du, X.,Gao, Z.Q.,Geng, Z.,Dong, Y.H.,Zhang, H. Structure and Biochemical Characteristic of the Methyltransferase (MTase) Domain of RNA Capping Enzyme from African Swine Fever Virus. J.Virol. 2020 0 0 0 6LGQ The crystal complex structure of histidine kinase and response regulator 2019-12-05 2020-12-09 Ming, Q.X. The crystal complex structure of histidine kinase and response regulator To Be Published 0 0 0 0 6LHF 33329601 Crystal structure of chicken cCD8aa/pBF2*15:01 2019-12-08 2020-12-09 Liu, Y.,Chen, R.,Liang, R.,Sun, B.,Wu, Y.,Zhang, L.,Kaufman, J.,Xia, C. The Combination of CD8 alpha alpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gamma delta T Cells Response. Front Immunol 2020 11 605085 605085 6LHG 33329601 Crystal structure of chicken cCD8aa/pBF2*04:01 2019-12-08 2020-12-09 Liu, Y.,Chen, R.,Liang, R.,Sun, B.,Wu, Y.,Zhang, L.,Kaufman, J.,Xia, C. The Combination of CD8 alpha alpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gamma delta T Cells Response. Front Immunol 2020 11 605085 605085 6LHH 33329601 Crystal structure of chicken 8mer-BF2*1501 2019-12-08 2020-12-09 Liu, Y.,Chen, R.,Liang, R.,Sun, B.,Wu, Y.,Zhang, L.,Kaufman, J.,Xia, C. The Combination of CD8 alpha alpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gamma delta T Cells Response. Front Immunol 2020 11 605085 605085 6LIH BRD4 BD1 bound with compound 10 2019-12-11 2020-12-16 Xiong, B.,Cao, D. BRD4 BD1 bound with compound 10 To Be Published 0 0 0 0 6LIM BRD4-BD1 bound with compound 40 2019-12-12 2020-12-16 Xiong, B.,Cao, D. BRD4-BD1 bound with compound 40 To Be Published 0 0 0 0 6LIP 33302045 Crystal structure of NDM-1 in complex with D-captopril derivative wss0218 2019-12-12 2020-12-16 Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors. Bioorg.Med.Chem. 2020 29 115902 115902 6LJ1 33302045 Crystal structure of NDM-1 in complex with D-captopril derivative wss02127 monomer 2019-12-13 2020-12-16 Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors. Bioorg.Med.Chem. 2020 29 115902 115902 6LJ2 33302045 Crystal structure of NDM-1 in complex with heterodimer of D-captopril derivative wss02127 stereoisomer 2019-12-13 2020-12-16 Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors. Bioorg.Med.Chem. 2020 29 115902 115902 6LJ8 33302045 Crystal structure of NDM-1 in complex with D-captopril derivative wss04134 2019-12-13 2020-12-16 Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H. Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors. Bioorg.Med.Chem. 2020 29 115902 115902 6LJG Crassostrea gigas ferritin mutant-D119G 2019-12-15 2020-12-16 Li, H.,Zang, J.,Tan, X.,Wang, Z.,Du, M. Crassostrea gigas ferritin mutant-D119G To Be Published 0 0 0 0 6M09 33284325 The ligand-free structure of the chloroplast protein At3g03890 2020-02-20 2020-12-16 Wang, J.,Guo, Q.,Li, X.,Wang, X.,Liu, L. The Arabidopsis locus AT3G03890 encodes a dimeric beta-barrel protein implicated in heme degradation. Biochem.J. 2020 0 0 0 6M0A 33284325 The heme-bound structure of the chloroplast protein At3g03890 2020-02-20 2020-12-16 Wang, J.,Guo, Q.,Li, X.,Wang, X.,Liu, L. The Arabidopsis locus AT3G03890 encodes a dimeric beta-barrel protein implicated in heme degradation. Biochem.J. 2020 0 0 0 6V3W 34375612 Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397 2019-11-26 2020-12-16 Gozgit, J.M.,Vasbinder, M.M.,Abo, R.P.,Kunii, K.,Kuplast-Barr, K.G.,Gui, B.,Lu, A.Z.,Molina, J.R.,Minissale, E.,Swinger, K.K.,Wigle, T.J.,Blackwell, D.J.,Majer, C.R.,Ren, Y.,Niepel, M.,Varsamis, Z.A.,Nayak, S.P.,Bamberg, E.,Mo, J.R.,Church, W.D.,Mady, A.S.A.,Song, J.,Utley, L.,Rao, P.E.,Mitchison, T.J.,Kuntz, K.W.,Richon, V.M.,Keilhack, H. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Cancer Cell 2021 39 1214 0 7CMW 33264017 Complex structure of PARP1 catalytic domain with pamiparib 2020-07-29 2020-12-16 Wang, H.,Ren, B.,Liu, Y.,Jiang, B.,Guo, Y.,Wei, M.,Luo, L.,Kuang, X.,Qiu, M.,Lv, L.,Xu, H.,Qi, R.,Yan, H.,Xu, D.,Wang, Z.,Huo, C.X.,Zhu, Y.,Zhao, Y.,Wu, Y.,Qin, Z.,Su, D.,Tang, T.,Wang, F.,Sun, X.,Feng, Y.,Peng, H.,Wang, X.,Gao, Y.,Liu, Y.,Gong, W.,Yu, F.,Liu, X.,Wang, L.,Zhou, C. Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development. J.Med.Chem. 2020 63 15541 15563 7CNT Structure of 2,5-dihydroxypridine Dioxygenase from Pseudomonas putida KT2440 in complex with product N-formylmaleamic acid formed via in crystallo reaction with 2,5-dihydroxypridine 2020-08-03 2020-12-16 Liu, G.Q.,Tang, H.Z. 2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid Nat Commun 2020 0 0 0 6LJL 33627653 Crystal Structure of exoHep-Y390A/H555A complexed with a tetrasaccharide substrate 2019-12-17 2020-12-23 Zhang, Q.,Cao, H.Y.,Wei, L.,Lu, D.,Du, M.,Yuan, M.,Shi, D.,Chen, X.,Wang, P.,Chen, X.L.,Chi, L.,Zhang, Y.Z.,Li, F. Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat Commun 2021 12 1263 1263 6LK5 34158471 MLKL mutant - T357ES358D 2019-12-18 2020-12-23 Zhang, Y.,Liu, J.,Yu, D.,Zhu, X.,Liu, X.,Liao, J.,Li, S.,Wang, H. The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling. Cell Death Dis 2021 12 638 638 6LKC 33587627 Crystal structure of PfaD from Shewanella piezotolerans in complex with FMN 2019-12-19 2020-12-23 Zhang, M.,Zhang, H.,Li, Q.,Gao, Y.,Guo, L.,He, L.,Zang, S.,Guo, X.,Huang, J.,Li, L. Structural Insights into the Trans -Acting Enoyl Reductase in the Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Shewanella piezotolerans . J.Agric.Food Chem. 2021 69 2316 2324 6LKY Crystal structure of isocitrate dehydrogenase from Methylococcus capsulatus 2019-12-21 2020-12-23 Zhu, G.P. Crystal structure of isocitrate dehydrogenase from Methylococcus capsulatus To Be Published 0 0 0 0 6LOJ 33303953 The complex structure of IpaH9.8-LRR and hGBP1 2020-01-06 2020-12-23 Ye, Y.,Xiong, Y.,Huang, H. Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8. Commun Biol 2020 3 752 752 6LOL 33303953 The crystal structure of full length IpaH9.8 2020-01-06 2020-12-23 Ye, Y.,Xiong, Y.,Huang, H. Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8. Commun Biol 2020 3 752 752 7BSC 33414219 Complex structure of 1G5.3 Fab bound to DENV2 NS1c 2020-03-30 2020-12-23 Modhiran, N.,Song, H.,Liu, L.,Bletchly, C.,Brillault, L.,Amarilla, A.A.,Xu, X.,Qi, J.,Chai, Y.,Cheung, S.T.M.,Traves, R.,Setoh, Y.X.,Bibby, S.,Scott, C.A.P.,Freney, M.E.,Newton, N.D.,Khromykh, A.A.,Chappell, K.J.,Muller, D.A.,Stacey, K.J.,Landsberg, M.J.,Shi, Y.,Gao, G.F.,Young, P.R.,Watterson, D. A broadly protective antibody that targets the flavivirus NS1 protein. Science 2021 371 190 194 7BSD 33414219 Complex structure of 1G5.3 Fab bound to ZIKV NS1c 2020-03-30 2020-12-23 Modhiran, N.,Song, H.,Liu, L.,Bletchly, C.,Brillault, L.,Amarilla, A.A.,Xu, X.,Qi, J.,Chai, Y.,Cheung, S.T.M.,Traves, R.,Setoh, Y.X.,Bibby, S.,Scott, C.A.P.,Freney, M.E.,Newton, N.D.,Khromykh, A.A.,Chappell, K.J.,Muller, D.A.,Stacey, K.J.,Landsberg, M.J.,Shi, Y.,Gao, G.F.,Young, P.R.,Watterson, D. A broadly protective antibody that targets the flavivirus NS1 protein. Science 2021 371 190 194 7D6M Crystal structure of tick-borne encephalitis virus methyltransferase 2020-10-01 2020-12-23 Yang, J.,Jing, X.,Zhang, B.,Zheng, Z.,Gong, P. Crystal structure of tick-borne encephalitis virus Nucleic Acids Res. 2020 0 0 0 7D6N Crystal structure of tick-borne encephalitis virus RNA-dependent RNA polymerase 2020-10-01 2020-12-23 Yang, J.,Jing, X.,Zhang, B.,Zheng, Z.,Gong, P. Crystal structure of tick-borne encephalitis virus Nucleic Acids Res. 2020 0 0 0 7DK8 33272567 Crystal structure of OsGH3-8 with AMP 2020-11-23 2020-12-23 Xu, G.,Zhang, Y.,Li, M.,Jiao, X.,Zhou, L.,Ming, Z. Crystal structure of the acyl acid amido synthetase GH3-8 from Oryza sativa. Biochem.Biophys.Res.Commun. 2021 534 266 271 7DM1 33504803 crystal structure of the M.tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-36 2020-12-01 2020-12-23 Watson, A.,Li, H.,Ma, B.,Weiss, R.,Bendayan, D.,Abramovitz, L.,Ben-Shalom, N.,Mor, M.,Pinko, E.,Bar Oz, M.,Wang, Z.,Du, F.,Lu, Y.,Rybniker, J.,Dahan, R.,Huang, H.,Barkan, D.,Xiang, Y.,Javid, B.,Freund, N.T. Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat Commun 2021 12 602 602 7DM2 33504803 crystal structure of the M. tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-170 2020-12-01 2020-12-23 Watson, A.,Li, H.,Ma, B.,Weiss, R.,Bendayan, D.,Abramovitz, L.,Ben-Shalom, N.,Mor, M.,Pinko, E.,Bar Oz, M.,Wang, Z.,Du, F.,Lu, Y.,Rybniker, J.,Dahan, R.,Huang, H.,Barkan, D.,Xiang, Y.,Javid, B.,Freund, N.T. Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat Commun 2021 12 602 602 6LNA 32966796 YdiU complex with AMPNPP and Mn2+ 2019-12-28 2020-12-30 Yang, Y.,Yue, Y.,Song, N.,Li, C.,Yuan, Z.,Wang, Y.,Ma, Y.,Li, H.,Zhang, F.,Wang, W.,Jia, H.,Li, P.,Li, X.,Wang, Q.,Ding, Z.,Dong, H.,Gu, L.,Li, B. The YdiU Domain Modulates Bacterial Stress Signaling through Mn 2+ -Dependent UMPylation. Cell Rep 2020 32 108161 108161 6LNL 33629764 ASFV core shell protein p15 2019-12-30 2020-12-30 Guo, F.,Shi, Y.,Yang, M.,Guo, Y.,Shen, Z.,Li, M.,Chen, Y.,Liang, R.,Yang, Y.,Chen, H.,Peng, G. The structural basis of African swine fever virus core shell protein p15 binding to DNA. Faseb J. 2021 35 0 0 6LO9 Crystal structure of RORgammat with ligand C46D bound 2020-01-04 2021-01-06 Feng, Y.,Shijie, C. Crystal structure of RORgammat with ligand C46D bound To Be Published 0 0 0 0 6LOB Crystal structure of RORgammat with ligand C46D bound 2020-01-04 2021-01-06 Feng, Y.,Shijie, C. Crystal structure of RORgammat with ligand C46D bound To Be Published 0 0 0 0 6LOC Crystal structure of RORgammat with ligand C46D bound 2020-01-04 2021-01-06 Feng, Y.,Shijie, C. Crystal structure of RORgammat with ligand C46D bound To Be Published 0 0 0 0 6LYR 33368572 Structure of the BAM complex 2020-02-15 2021-01-06 Xiao, L.,Han, L.,Li, B.,Zhang, M.,Zhou, H.,Luo, Q.,Zhang, X.,Huang, Y. Structures of the beta-barrel assembly machine recognizing outer membrane protein substrates. Faseb J. 2021 35 0 0 7CE3 33349631 Crystal structure of human IDH3 holoenzyme in APO form. 2020-06-21 2021-01-06 Sun, P.,Liu, Y.,Ma, T.,Ding, J. Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase. Cell Discov 2020 6 94 94 6L6N hASIC1a co-crystallized with Nafamostat 2019-10-29 2021-01-13 Lei, F.,Jian, S. hASIC1a co-crystallized with Mamb-1 To Be Published 0 0 0 0 6LP2 Structure of Lpg2148/UBE2N-Ub complex 2020-01-08 2021-01-13 Feng, Y.,Wang, Y.,Huang, Y.,Li, D. Structure of Lpg2148/UBE2N-Ub complex To Be Published 0 0 0 0 6LP4 Structural basis and functional analysis epo1-bem3p complex for bud growth 2020-01-08 2021-01-13 Wang, J. Structural basis and functional analysis epo1-bem3p complex for bud growth To Be Published 0 0 0 0 6LPD 33448656 Phascolosoma esculenta 2020-01-09 2021-01-13 Ming, T.,Huan, H.,Su, C.,Huo, C.,Wu, Y.,Jiang, Q.,Qiu, X.,Lu, C.,Zhou, J.,Li, Y.,Su, X. Structural comparison of two ferritins from the marine invertebrate Phascolosoma esculenta. Febs Open Bio 2021 11 793 803 6LPD 33448656 Phascolosoma esculenta 2020-01-09 2021-01-13 Ming, T.,Huan, H.,Su, C.,Huo, C.,Wu, Y.,Jiang, Q.,Qiu, X.,Lu, C.,Zhou, J.,Li, Y.,Su, X. Structural comparison of two ferritins from the marine invertebrate Phascolosoma esculenta. Febs Open Bio 2021 11 793 803 6LPH the Sufu-Fu complex crystal structure 2020-01-10 2021-01-13 Hua, L. Structure of the Sufu-Fu complex at 1.9 Angstroms resolution. To Be Published 0 0 0 0 6LPU 33431826 Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with L-2-hydroxyglutarate (L-2-HG) 2020-01-12 2021-01-13 Yang, J.,Zhu, H.,Zhang, T.,Ding, J. Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discov 2021 7 3 3 6LR9 33404528 HSP90 in complex with Debio0932 2020-01-15 2021-01-13 Qin, W.,Yu, F.,Zhou, H.,Li, P.,Zhou, F.,Li, H.J.,He, C.X.,Xing, L.,Zhou, X.,Zhao, D.,Li, P.Q.,Jin, X.,Wang, Q.S.,He, J.H.,Cao, H.L. Complex crystal structure determination and anti-non-small-cell lung cancer activity of the Hsp90 N inhibitor Debio0932. Acta Crystallogr D Struct Biol 2021 77 86 97 6LYS 33368572 Structure of the BAM complex 2020-02-15 2021-01-13 Xiao, L.,Han, L.,Li, B.,Zhang, M.,Zhou, H.,Luo, Q.,Zhang, X.,Huang, Y. Structures of the beta-barrel assembly machine recognizing outer membrane protein substrates. Faseb J. 2021 35 0 0 7CNA 33574238 Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide 2020-07-30 2021-01-13 Du, Y.,Yan, Y.,Xie, S.,Huang, H.,Wang, X.,Ng, R.K.,Zhou, M.M.,Qian, C. Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation. Nat Commun 2021 12 949 949 6KHT Chimeric beta-glucosidase Cel1b-H13 2019-07-16 2021-01-20 Niu, K.L. Chimeric beta-glucosidase Cel1b-H13 To Be Published 0 0 0 0 6L9I Crystal Structure of Lactobacillus farciminis Oxalate Decarboxylase Formate Complex 2019-11-10 2021-01-20 Wu, F.,Cheng, L.K.,Wang, C.Y. Crystal Structure of Lactobacillus farciminis Oxalate Decarboxylase Formate Complex To Be Published 0 0 0 0 6LOH Crystal structure of the catalytic domain of human ubiquitin ligase AREL1 2020-01-05 2021-01-20 Li, Z.H.,Shang, G.H.,Tang, C.J.,Tian, Z.Z.,Wu, W.,Chen, Z.Z. Crystal structure of the catalytic domain of human ubiquitin ligase AREL1 Prog.Biochem.Biophys. 2020 0 0 0 6LS0 rod-shaped crystal of TmFtn mutant-T4FY stimulited by PLL15 2020-01-16 2021-01-20 Zhao, G.,Zhang, X. rod-shaped crystal of TmFtn mutant-T4FY stimulited by PLL15 To Be Published 0 0 0 0 6LS3 cubic-shaped crystal of TmFtn mutant-T4FY stimulated by Mg 2020-01-16 2021-01-20 Zhao, G.,Zhang, X. cubic-shaped crystal of TmFtn mutant-T4FY stimulated by Mg To Be Published 0 0 0 0 6LS4 32931884 A novel anti-tumor agent S-40 in complex with tubulin 2020-01-17 2021-01-20 Du, T.,Lin, S.,Ji, M.,Xue, N.,Liu, Y.,Zhang, Z.,Zhang, K.,Zhang, J.,Zhang, Y.,Wang, Q.,Sheng, L.,Li, Y.,Lu, D.,Chen, X.,Xu, H. A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett. 2020 495 22 32 6W78 32459306 crystal structure of a plant ice-binding protein 2020-03-18 2021-01-20 Wang, Y.,Graham, L.A.,Han, Z.,Eves, R.,Gruneberg, A.K.,Campbell, R.L.,Zhang, H.,Davies, P.L. Carrot 'antifreeze' protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization. Biochem.J. 2020 477 2179 2192 6W78 32459306 crystal structure of a plant ice-binding protein 2020-03-18 2021-01-20 Wang, Y.,Graham, L.A.,Han, Z.,Eves, R.,Gruneberg, A.K.,Campbell, R.L.,Zhang, H.,Davies, P.L. Carrot 'antifreeze' protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization. Biochem.J. 2020 477 2179 2192 7C7E 33224125 Crystal structure of C terminal domain of Escherichia coli DgoR 2020-05-25 2021-01-20 Lin, Z.,Sun, Y.,Liu, Y.,Tong, S.,Shang, Z.,Cai, Y.,Lin, W. Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket. Front Microbiol 2020 11 590330 590330 6LSZ HSP 90 in complex with Ganetespib 2020-01-20 2021-01-27 Cao, H.L. Structure of HSP90 in complex with Ganetespib To Be Published 0 0 0 0 6LT8 33610655 HSP90 in complex with KW-2478 2020-01-21 2021-01-27 Li, H.J.,Wang, Q.S.,Han, W.,Zhou, H.,Li, P.,Zhou, F.,Qin, W.,Zhao, D.,Zhou, X.,He, C.X.,Xing, L.,Li, P.Q.,Jin, X.,Yu, F.,He, J.H.,Cao, H.L. Anti-NSCLC activity in vitro of Hsp90 N inhibitor KW-2478 and complex crystal structure determination of Hsp90 N -KW-2478. J.Struct.Biol. 2021 213 107710 107710 6LTI HSP90 in complex with NVP-AUY922 2020-01-22 2021-01-27 Cao, H.L. HSP90 in complex with NVP-AUY922 To Be Published 0 0 0 0 6LTK 33855025 HSP90 in complex with SNX-2112 2020-01-22 2021-01-27 Zhao, D.,Xu, Y.M.,Cao, L.Q.,Yu, F.,Zhou, H.,Qin, W.,Li, H.J.,He, C.X.,Xing, L.,Zhou, X.,Li, P.Q.,Jin, X.,He, Y.,He, J.H.,Cao, H.L. Complex Crystal Structure Determination and in vitro Anti-non-small Cell Lung Cancer Activity of Hsp90 N Inhibitor SNX-2112. Front Cell Dev Biol 2021 9 650106 650106 6LUJ 33980486 Crystal structure of the SAMD1 SAM domain 2020-01-29 2021-02-03 Stielow, B.,Zhou, Y.,Cao, Y.,Simon, C.,Pogoda, H.M.,Jiang, J.,Ren, Y.,Phanor, S.K.,Rohner, I.,Nist, A.,Stiewe, T.,Hammerschmidt, M.,Shi, Y.,Bulyk, M.L.,Wang, Z.,Liefke, R. The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv 2021 7 0 0 7BZD 33495458 Structure of Bacillus subtilis HxlR, wild type 2020-04-27 2021-02-03 Zhu, R.,Zhang, G.,Jing, M.,Han, Y.,Li, J.,Zhao, J.,Li, Y.,Chen, P.R. Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nat Commun 2021 12 581 581 7BZG 33495458 Structure of Bacillus subtilis HxlR, wild type in complex with formaldehyde and DNA 2020-04-27 2021-02-03 Zhu, R.,Zhang, G.,Jing, M.,Han, Y.,Li, J.,Zhao, J.,Li, Y.,Chen, P.R. Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nat Commun 2021 12 581 581 7CSX 33577684 Crystal structure of the N-terminal tandem RRM domains of RBM45 2020-08-17 2021-02-03 Chen, X.,Yang, Z.,Wang, W.,Qian, K.,Liu, M.,Wang, J.,Wang, M. Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45. Nucleic Acids Res. 2021 49 2946 2958 6LBI 33577686 Crystal Structure of FOXO1-DBD homodimer bound to a palindromic DNA sequence 2019-11-14 2021-02-10 Li, J.,Dai, S.,Chen, X.,Liang, X.,Qu, L.,Jiang, L.,Guo, M.,Zhou, Z.,Wei, H.,Zhang, H.,Chen, Z.,Chen, L.,Chen, Y. Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. Nucleic Acids Res. 2021 49 3573 3583 6LBM 33577686 Crystal Structure of FOXC2-DBD bound to a palindromic DNA sequence 2019-11-14 2021-02-10 Li, J.,Dai, S.,Chen, X.,Liang, X.,Qu, L.,Jiang, L.,Guo, M.,Zhou, Z.,Wei, H.,Zhang, H.,Chen, Z.,Chen, L.,Chen, Y. Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. Nucleic Acids Res. 2021 49 3573 3583 7DNO 33668971 Characterization of Peptide Ligands Against WDR5 Isolated Using Phage Display Technique 2020-12-10 2021-02-10 Cao, J.,Fan, T.,Li, Y.,Du, Z.,Chen, L.,Wang, Y.,Wang, X.,Shen, J.,Huang, X.,Xiong, B.,Cao, D. Phage-Display Based Discovery and Characterization of Peptide Ligands against WDR5. Molecules 2021 26 0 0 7BWT 33603205 SopD-Rab8 complex structure 2020-04-16 2021-02-24 Lian, H.,Jiang, K.,Tong, M.,Chen, Z.,Liu, X.,Galan, J.E.,Gao, X. The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response. Nat Microbiol 2021 6 658 671 7D5C 33712620 IleRS in complex with a tRNA site inhibitor 2020-09-25 2021-02-24 Chen, B.,Luo, S.,Zhang, S.,Ju, Y.,Gu, Q.,Xu, J.,Yang, X.L.,Zhou, H. Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase. Nat Commun 2021 12 1616 1616 7D8H 33556406 CRTC1 pSer64 peptide in complex with 14-3-3 zeta 2020-10-08 2021-02-24 Chen, H.,Zhang, H.,Chen, P.,Xiang, S. Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol. 2021 433 166874 166874 7D8P 33556406 CRTC1 pSer151 peptide in complex with 14-3-3 zeta 2020-10-08 2021-02-24 Chen, H.,Zhang, H.,Chen, P.,Xiang, S. Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol. 2021 433 166874 166874 7D9V 33556406 CRTC1 pSer245 peptide in complex with 14-3-3 zeta 2020-10-14 2021-02-24 Chen, H.,Zhang, H.,Chen, P.,Xiang, S. Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol. 2021 433 166874 166874 6LCY 34663975 Crystal structure of Synaptotagmin-7 C2B in complex with IP6 2019-11-20 2021-03-03 Zhang, X.,Li, N.,Zhang, J.,Zhang, Y.,Yang, X.,Luo, Y.,Zhang, B.,Xu, Z.,Zhu, Z.,Yang, X.,Yan, Y.,Lin, B.,Wang, S.,Chen, D.,Ye, C.,Ding, Y.,Lou, M.,Wu, Q.,Hou, Z.,Zhang, K.,Liang, Z.,Wei, A.,Wang, B.,Wang, C.,Jiang, N.,Zhang, W.,Xiao, G.,Ma, C.,Ren, Y.,Qi, X.,Han, W.,Wang, C.,Rao, F. 5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab 2021 3 1400 1414 6LF8 34937745 Crystal structure of pSLA-1*0401 complex with dodecapeptide RVEDVTNTAEYW 2019-11-30 2021-03-03 Wei, X.,Wang, S.,Wang, S.,Xie, X.,Zhang, N. Structure and Peptidomes of Swine MHC Class I with Long Peptides Reveal the Cross-Species Characteristics of the Novel N-Terminal Extension Presentation Mode. J Immunol. 2022 208 480 491 6M2B 32754890 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416 2020-02-27 2021-03-03 Xiong, R.,Zhang, L.,Li, S.,Sun, Y.,Ding, M.,Wang, Y.,Zhao, Y.,Wu, Y.,Shang, W.,Jiang, X.,Shan, J.,Shen, Z.,Tong, Y.,Xu, L.,Chen, Y.,Liu, Y.,Zou, G.,Lavillete, D.,Zhao, Z.,Wang, R.,Zhu, L.,Xiao, G.,Lan, K.,Li, H.,Xu, K. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell 2020 11 723 739 7E5C Bacterial prolidase mutant D45W/L225Y/H226L/H343I 2021-02-18 2021-03-03 Yang, J.,Xiao, Y.,Liu, Y.,Li, R.,Long, L. Structure-based redesign of the bacterial prolidase active-site pocket for efficient enhancement of methyl-parathion hydrolysis Catalysis Science And Technolo 2021 11 5086 5093 6M4X Co-crystal structure of Ac-AChBPP in complex with [N9A]LvIA 2020-03-09 2021-03-10 Zhu, X.P.,Pan, S.,Wang, X.Q.,Luo, S.L. The crystal structure of Ac-AChBP in complex with LvIA analogs reveals the mechanism of its selectivity towards different nAChR subtypes To Be Published 0 0 0 0 7DUN Crystal structure of Fab fragment of Daratumumab 2021-01-10 2021-03-10 Yu, X.J.,Wang, L.,Yu, C.F. Crystal structure of Fab fragment of Daratumumab To Be Published 0 0 0 0 7DUO Crystal structure of daratumumab fab and CD38 complex 2021-01-10 2021-03-10 Yu, X.J.,Wang, L.,Yu, C.F. Crystal structure of daratumumab fab and CD38 complex To Be Published 0 0 0 0 7E36 33828077 A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis 2021-02-08 2021-03-10 Wang, K.B.,Wang, W.,Zhang, B.,Wang, X.,Chen, Y.,Zhu, H.J.,Liang, Y.,Tan, R.X.,Ge, H.M. A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis. Nat Commun 2021 12 2092 2092 6M5F Crystal structure of HinK, a LysR family transcriptional regulator from Pseudomonas aeruginosa 2020-03-10 2021-03-17 Wang, Y.,Lan, L.,Cao, Q.,Gan, J.,Wang, F. Crystal structure of HinK, a LysR family transcriptional regulator from Pseudomonas aeruginosa To Be Published 0 0 0 0 6M6L The crystal structure of glycosidase hydrolyzing Notoginsenoside 2020-03-15 2021-03-17 Wang, R.F. Characterization and Structural Elucidation of Enhanced Catalytic Activity upon Engineering Glycosidase KfGH01 for the Production of Vina-ginsenoside R7 To Be Published 0 0 0 0 6M6M The crystal structure of glycosidase mutant 2020-03-15 2021-03-17 Wang, R.F. Characterization and Structural Elucidation of Enhanced Catalytic Activity upon Engineering Glycosidase KfGH01 for the Production of Vina-ginsenoside R7 To Be Published 0 0 0 0 7C96 33658365 Avr1d:GmPUB13 U-box 2020-06-05 2021-03-17 Lin, Y.,Hu, Q.,Zhou, J.,Yin, W.,Yao, D.,Shao, Y.,Zhao, Y.,Guo, B.,Xia, Y.,Chen, Q.,Wang, Y.,Ye, W.,Xie, Q.,Tyler, B.M.,Xing, W.,Wang, Y. Phytophthora sojae effector Avr1d functions as an E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7D8I 33955674 Crystal structure of nucleoside phosphatase Sa1684 complex with ATP analogue from staphylococus aureus 2020-10-08 2021-03-17 Wang, Z.,Shen, H.,He, B.,Teng, M.,Guo, Q.,Li, X. The structural mechanism for the nucleoside tri- and diphosphate hydrolysis activity of Ntdp from Staphylococcus aureus. Febs J. 2021 288 6019 6034 7DCY 33788943 Apo form of Mycoplasma genitalium RNase R 2020-10-27 2021-03-17 Abula, A.,Li, X.,Quan, X.,Yang, T.,Liu, Y.,Guo, H.,Li, T.,Ji, X. Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res. 2021 49 4738 4749 7DHP 33679894 Crystal structure of MazF from Deinococcus radiodurans 2020-11-17 2021-03-17 Dai, J.,Chen, Z.,Hou, J.,Wang, Y.,Guo, M.,Cao, J.,Wang, L.,Xu, H.,Tian, B.,Zhao, Y. MazEF Toxin-Antitoxin System-Mediated DNA Damage Stress Response in Deinococcus radiodurans. Front Genet 2021 12 632423 632423 7DIC 33788943 Mycoplasma genitalium RNase R in complex with single-stranded RNA 2020-11-18 2021-03-17 Abula, A.,Li, X.,Quan, X.,Yang, T.,Liu, Y.,Guo, H.,Li, T.,Ji, X. Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res. 2021 49 4738 4749 7DID 33788943 Mycoplasma genitalium RNase R in complex with ribose methylated single-stranded RNA 2020-11-18 2021-03-17 Abula, A.,Li, X.,Quan, X.,Yang, T.,Liu, Y.,Guo, H.,Li, T.,Ji, X. Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res. 2021 49 4738 4749 7DOL 33788943 Mycoplasma genitalium RNase R in complex with double-stranded RNA 2020-12-14 2021-03-17 Abula, A.,Li, X.,Quan, X.,Yang, T.,Liu, Y.,Guo, H.,Li, T.,Ji, X. Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Res. 2021 49 4738 4749 7E2K 33676185 Crystal structure of the RWD domain of human GCN2 - 1 2021-02-05 2021-03-17 Hei, Z.,Wu, S.,Zheng, L.,Zhou, J.,Liu, Z.,Wang, J.,Fang, P. Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun. 2021 549 164 170 7E2M 33676185 Crystal structure of the RWD domain of human GCN2 - 2 2021-02-05 2021-03-17 Hei, Z.,Wu, S.,Zheng, L.,Zhou, J.,Liu, Z.,Wang, J.,Fang, P. Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun. 2021 549 164 170 7E35 33979649 Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant bound to compound S43 2021-02-08 2021-03-17 Shan, H.,Liu, J.,Shen, J.,Dai, J.,Xu, G.,Lu, K.,Han, C.,Wang, Y.,Xu, X.,Tong, Y.,Xiang, H.,Ai, Z.,Zhuang, G.,Hu, J.,Zhang, Z.,Li, Y.,Pan, L.,Tan, L. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol 2021 28 855 0 7E6Q 35423449 Crystal structure of influenza A virus neuraminidase N5 complexed with 4'-phenyl-1,2,3-triazolylated oseltamivir carboxylate 2021-02-23 2021-03-17 Wang, P.,Oladejo, B.O.,Li, C.,Fu, L.,Zhang, S.,Qi, J.,Lv, X.,Li, X. Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors. Rsc Adv 2021 11 9528 9541 7EAM immune complex of SARS-CoV-2 RBD and cross-neutralizing antibody 7D6 2021-03-07 2021-03-17 Li, T.,Xue, W.,Zheng, Q.,Song, S.,Yang, C.,Xiong, H.,Zhang, S.,Hong, M.,Zhang, Y.,Yu, H.,Zhang, Y.,Sun, H.,Huang, Y.,Deng, T.,Chi, X.,Li, J.,Wang, S.,Zhou, L.,Chen, T.,Wang, Y.,Cheng, T.,Zhang, T.,Yuan, Q.,Zhao, Q.,Zhang, J.,McLellan, J.S.,Zhou, Z.H.,Zhang, Z.,Li, S.,Gu, Y.,Xia, N. Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nat Commun 2021 12 5652 0 7BPK 34267374 Zika virus envelope protein mutant bound to mAb 2020-03-23 2021-03-24 Dai, L.,Xu, K.,Li, J.,Huang, Q.,Song, J.,Han, Y.,Zheng, T.,Gao, P.,Lu, X.,Yang, H.,Liu, K.,Xia, Q.,Wang, Q.,Chai, Y.,Qi, J.,Yan, J.,Gao, G.F. Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch. Nat.Immunol. 2021 22 958 968 7BQ5 34267374 ZIKV sE bound to mAb Z6 2020-03-24 2021-03-24 Dai, L.,Xu, K.,Li, J.,Huang, Q.,Song, J.,Han, Y.,Zheng, T.,Gao, P.,Lu, X.,Yang, H.,Liu, K.,Xia, Q.,Wang, Q.,Chai, Y.,Qi, J.,Yan, J.,Gao, G.F. Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch. Nat.Immunol. 2021 22 958 968 7CNB 33689296 Crystal structure of Gp16 C-terminal domain from Bacillus virus phi29 2020-07-30 2021-03-24 Saeed, A.F.U.H.,Chan, C.,Guan, H.,Gong, B.,Guo, P.,Cheng, X.,Ouyang, S. Structural Insights into gp16 ATPase in the Bacteriophage φ29 DNA Packaging Motor. Biochemistry 2021 60 886 897 7CRV 33731929 Crystal structure of rNLRP1-FIIND 2020-08-14 2021-03-24 Huang, M.,Zhang, X.,Toh, G.A.,Gong, Q.,Wang, J.,Han, Z.,Wu, B.,Zhong, F.,Chai, J. Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Nature 2021 592 773 777 6L71 Sirtuin 2 demyristoylation native intermediate I & II mixture 2019-10-30 2021-03-31 Chen, L.F. Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published 0 0 0 0 6L72 Sirtuin 2 demyristoylation native final product 2019-10-30 2021-03-31 Chen, L.F. Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published 0 0 0 0 6LHD 33863900 Crystal structure of p53/BCL-xL fusion complex 2019-12-07 2021-03-31 Wei, H.,Qu, L.,Dai, S.,Li, Y.,Wang, H.,Feng, Y.,Chen, X.,Jiang, L.,Guo, M.,Li, J.,Chen, Z.,Chen, L.,Zhang, Y.,Chen, Y. Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis. Nat Commun 2021 12 2280 2280 7CZG 33692357 Crystal structure of FIP200 Claw domain apo form 2020-09-08 2021-03-31 Zhou, Z.,Liu, J.,Fu, T.,Wu, P.,Peng, C.,Gong, X.,Wang, Y.,Zhang, M.,Li, Y.,Wang, Y.,Xu, X.,Li, M.,Pan, L. Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun 2021 12 1570 1570 7CZM 33692357 Crystal structure of FIP200 Claw/p-OPtineurin LIR complex 2020-09-09 2021-03-31 Zhou, Z.,Liu, J.,Fu, T.,Wu, P.,Peng, C.,Gong, X.,Wang, Y.,Zhang, M.,Li, Y.,Wang, Y.,Xu, X.,Li, M.,Pan, L. Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun 2021 12 1570 1570 7DET 33961621 Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody scFv 2020-11-05 2021-03-31 Fu, D.,Zhang, G.,Wang, Y.,Zhang, Z.,Hu, H.,Shen, S.,Wu, J.,Li, B.,Li, X.,Fang, Y.,Liu, J.,Wang, Q.,Zhou, Y.,Wang, W.,Li, Y.,Lu, Z.,Wang, X.,Nie, C.,Tian, Y.,Chen, D.,Wang, Y.,Zhou, X.,Wang, Q.,Yu, F.,Zhang, C.,Deng, C.,Zhou, L.,Guan, G.,Shao, N.,Lou, Z.,Deng, F.,Zhang, H.,Chen, X.,Wang, M.,Liu, L.,Rao, Z.,Guo, Y. Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes. Plos Biol. 2021 19 0 0 7DKZ 33788400 Structure of plant photosystem I-light harvesting complex I supercomplex 2020-11-25 2021-03-31 Wang, J.,Yu, L.J.,Wang, W.,Yan, Q.,Kuang, T.,Qin, X.,Shen, J.R. Structure of plant photosystem I-light harvesting complex I supercomplex at 2.4 angstrom resolution. J Integr Plant Biol 2021 63 1367 1381 7DRQ 33771786 Crystal structure of polysaccharide lyase Uly1 2020-12-29 2021-03-31 Xu, F.,Dong, F.,Sun, X.H.,Cao, H.Y.,Fu, H.H.,Li, C.Y.,Zhang, X.Y.,McMinn, A.,Zhang, Y.Z.,Wang, P.,Chen, X.L. Mechanistic Insights into Substrate Recognition and Catalysis of a New Ulvan Lyase of Polysaccharide Lyase Family 24. Appl.Environ.Microbiol. 2021 87 0 0 7EAN 34580306 immune complex of SARS-CoV-2 RBD and cross-neutralizing antibody 6D6 2021-03-07 2021-03-31 Li, T.,Xue, W.,Zheng, Q.,Song, S.,Yang, C.,Xiong, H.,Zhang, S.,Hong, M.,Zhang, Y.,Yu, H.,Zhang, Y.,Sun, H.,Huang, Y.,Deng, T.,Chi, X.,Li, J.,Wang, S.,Zhou, L.,Chen, T.,Wang, Y.,Cheng, T.,Zhang, T.,Yuan, Q.,Zhao, Q.,Zhang, J.,McLellan, J.S.,Zhou, Z.H.,Zhang, Z.,Li, S.,Gu, Y.,Xia, N. Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nat Commun 2021 12 5652 5652 7BIL 33784404 Crystal structure of helicase Pif1 from Thermus oshimai in complex with oligo GGTTTGGTTTGGTT 2021-01-12 2021-04-07 Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G. Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition. Nucleic Acids Res. 2021 49 4129 4143 7C42 33332555 The crystal structure of Trypanosoma brucei RNase D 2020-05-14 2021-04-07 Gao, Y.,Liu, H.,Zhang, C.,Su, S.,Chen, Y.,Chen, X.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Li, J.,Huang, Z.,Ma, J.,Gan, J. Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei. Nucleic Acids Res. 2021 49 568 583 7CA8 33163253 The crystal structure of COVID-19 main protease in complex with an inhibitor Shikonin 2020-06-08 2021-04-07 Li, J.,Zhou, X.,Zhang, Y.,Zhong, F.,Lin, C.,McCormick, P.J.,Jiang, F.,Luo, J.,Zhou, H.,Wang, Q.,Fu, Y.,Duan, J.,Zhang, J. Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. Sci Bull (Beijing) 2021 66 661 663 7CAJ 33511756 Crystal structure of SETDB1 Tudor domain in complexed with Compound 2. 2020-06-08 2021-04-07 Guo, Y.,Mao, X.,Xiong, L.,Xia, A.,You, J.,Lin, G.,Wu, C.,Huang, L.,Wang, Y.,Yang, S. Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl. 2021 60 8760 8765 7CB0 34099682 The apo 6-phosphogluconate dehydrogenase from Staphylococcus aureus (strain Newman) 2020-06-10 2021-04-07 Wang, H.,Wang, M.,Xu, X.,Gao, P.,Xu, Z.,Zhang, Q.,Li, H.,Yan, A.,Kao, R.Y.,Sun, H. Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance. Nat Commun 2021 12 3331 3331 7CB5 34099682 The 6-phosphogluconate dehydrogenase from Staphylococcus aureus (6-phosphogluconate bound) 2020-06-10 2021-04-07 Wang, H.,Wang, M.,Xu, X.,Gao, P.,Xu, Z.,Zhang, Q.,Li, H.,Yan, A.,Kao, R.Y.,Sun, H. Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance. Nat Commun 2021 12 3331 3331 7CB6 34099682 The silver-bound 6-phosphogluconate dehydrogenase from Staphylococcus aureus (strain Newman) 2020-06-10 2021-04-07 Wang, H.,Wang, M.,Xu, X.,Gao, P.,Xu, Z.,Zhang, Q.,Li, H.,Yan, A.,Kao, R.Y.,Sun, H. Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance. Nat Commun 2021 12 3331 3331 7CE2 33951441 The Crystal structure of TeNT Hc complexed with neutralizing antibody 2020-06-21 2021-04-07 Wang, Y.,Wu, C.,Yu, J.,Lin, S.,Liu, T.,Zan, L.,Li, N.,Hong, P.,Wang, X.,Jia, Z.,Li, J.,Wang, Y.,Zhang, M.,Yuan, X.,Li, C.,Xu, W.,Zheng, W.,Wang, X.,Liao, H.X. Structural basis of tetanus toxin neutralization by native human monoclonal antibodies. Cell Rep 2021 35 109070 109070 7CGW 33527708 Complex structure of PD-1 and tislelizumab Fab 2020-07-02 2021-04-07 Hong, Y.,Feng, Y.,Sun, H.,Zhang, B.,Wu, H.,Zhu, Q.,Li, Y.,Zhang, T.,Zhang, Y.,Cui, X.,Li, Z.,Song, X.,Li, K.,Liu, M.,Liu, Y. Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. Febs Open Bio 2021 11 782 792 7D2E 33761347 Tetrameric coiled-coil structure of liprin-alpha2_H3 2020-09-16 2021-04-07 Liang, M.,Jin, G.,Xie, X.,Zhang, W.,Li, K.,Niu, F.,Yu, C.,Wei, Z. Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep 2021 34 108901 108901 7D2G 33761347 Coiled-coil structure of liprin-alpha2_H2delC 2020-09-16 2021-04-07 Liang, M.,Jin, G.,Xie, X.,Zhang, W.,Li, K.,Niu, F.,Yu, C.,Wei, Z. Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep 2021 34 108901 108901 7D2H 33761347 Tetrameric coiled-coil structure of liprin-alpha2_H2 2020-09-16 2021-04-07 Liang, M.,Jin, G.,Xie, X.,Zhang, W.,Li, K.,Niu, F.,Yu, C.,Wei, Z. Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep 2021 34 108901 108901 7DE9 34099688 crystal structure of Arabidopsis RDM15 tudor domain in complex with an H3K4me1 peptide 2020-11-03 2021-04-07 Niu, Q.,Song, Z.,Tang, K.,Chen, L.,Wang, L.,Ban, T.,Guo, Z.,Kim, C.,Zhang, H.,Duan, C.G.,Zhang, H.,Zhu, J.K.,Du, J.,Lang, Z. A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation. Nat Commun 2021 12 3367 3367 7C88 32839442 Complex structure of JS003 and PD-L1 2020-05-29 2021-04-14 Liu, H.,Bi, X.,Zhou, Y.,Shi, R.,Yao, S.,Qi, J.,Feng, H.,Feng, M.,Yan, J.,Tan, S. Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy. Signal Transduct Target Ther 2020 5 158 158 7C8P 33453651 Structural and functional characterization of human group A rotavirus P[25] VP8* 2020-06-03 2021-04-14 Li, D.,Wang, M.,Qi, J.,Zhang, Q.,Wang, H.,Pang, L.,Sun, X.,Duan, Z. Human group A rotavirus P[25] VP8* specifically binds to A-type histo-blood group antigen. Virology 2021 555 56 63 7CJ0 33857403 Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD 2020-07-09 2021-04-14 Hammond, C.M.,Bao, H.,Hendriks, I.A.,Carraro, M.,Garcia-Nieto, A.,Liu, Y.,Reveron-Gomez, N.,Spanos, C.,Chen, L.,Rappsilber, J.,Nielsen, M.L.,Patel, D.J.,Huang, H.,Groth, A. DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network. Mol.Cell 2021 81 2533 0 7CJT 33511756 Crystal Structure of SETDB1 Tudor domain in complexed with (R,R)-59 2020-07-13 2021-04-14 Guo, Y.,Mao, X.,Xiong, L.,Xia, A.,You, J.,Lin, G.,Wu, C.,Huang, L.,Wang, Y.,Yang, S. Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl. 2021 60 8760 8765 7DKG 33784403 Influenza H5N1 nucleoprotein (truncated) in complex with nucleotides 2020-11-24 2021-04-14 Tang, Y.S.,Xu, S.,Chen, Y.W.,Wang, J.H.,Shaw, P.C. Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. Nucleic Acids Res. 2021 49 4144 4154 7DXP 33784403 Influenza H5N1 nucleoprotein in complex with nucleotides 2021-01-19 2021-04-14 Tang, Y.S.,Xu, S.,Chen, Y.W.,Wang, J.H.,Shaw, P.C. Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. Nucleic Acids Res. 2021 49 4144 4154 7E7N Crystal structure of RSL mutant-R17A/R108A/R199A in complex with R3F 2021-02-26 2021-04-14 Li, L.,Chen, G.S. Crystal structure of RSL mutant in complex with suger Ligand To Be Published 0 0 0 0 7E7R Crystal structure of RSL mutant in complex with Ligand 2021-02-27 2021-04-14 Li, L.,Chen, G.S. Crystal structure of RSL mutant-R17A/R108A/R199A in complex with R3F To Be Published 0 0 0 0 7E7T Crystal structure of RSL mutant in complex with sugar Ligand 2021-02-27 2021-04-14 Li, L.,Chen, G.S. Crystal structure of RSL mutant-R17A/R108A/R199A in complex with R2F To Be Published 0 0 0 0 7E7U Crystal structure of RSL mutant in complex with sugar Ligand 2021-02-27 2021-04-14 Li, L.,Chen, G.S. Crystal structure of RSL mutant in complex with Ligand To Be Published 0 0 0 0 7E7V Crystal structure of RSL mutant in complex with sugar Ligand 2021-02-28 2021-04-14 Li, L.,Chen, G.S. Crystal structure of RSL mutant in complex with Ligand To Be Published 0 0 0 0 7BWU Restructuring hemagglutinin-neuraminidase (HN) of Newcastle disease virus produced from Oryza sativa 2020-04-16 2021-04-21 Ma, F.S.,Zhang, E.Q.,Xu, Q.R.,Guo, J.Q.,Zhang, G.P. Restructuring a dimer antigen in transgenic rice system for high efficient B cell activation: Development of a super effective vaccine against Newcastle Disease Virus To Be Published 0 0 0 0 7BWZ Crystal structure of RTT109 from CANDIDA ALBICANS 2020-04-16 2021-04-21 Chen, Y.P.,Lei, J.H.,Su, D. Crystal structure of RTT109 from CANDIDA ALBICANS To Be Published 0 0 0 0 7BX0 Crystal structure of RTT109 from Candida albicans 2020-04-16 2021-04-21 Lei, J.H.,Chen, Y.P.,Lu, D.R.,Su, D. Crystal structure of RTT109 from Candida albicans To Be Published 0 0 0 0 7BX1 Crystal structure of RTT109 from Candida albicans 2020-04-16 2021-04-21 Chen, Y.P.,Lei, J.H.,Lu, D.R.,Su, D. Crystal structure of RTT109 from Candida albicans To Be Published 0 0 0 0 7BXW Crystal structure ofF RTT109 FROM Candida albicans 2020-04-21 2021-04-21 Su, D.,Hu, Q. Crystal structure ofF RTT109 FROM Candida albicans To be published 0 0 0 0 7CFK 33912817 Structure of the CBS domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with the novel inhibitor IGN95a 2020-06-25 2021-04-21 Huang, Y.,Mu, K.,Teng, X.,Zhao, Y.,Funato, Y.,Miki, H.,Zhu, W.,Xu, Z.,Hattori, M. Identification and mechanistic analysis of an inhibitor of the CorC Mg 2+ transporter. Iscience 2021 24 102370 102370 7D7K 33864621 The crystal structure of SARS-CoV-2 papain-like protease in apo form 2020-10-04 2021-04-21 Zhao, Y.,Du, X.,Duan, Y.,Pan, X.,Sun, Y.,You, T.,Han, L.,Jin, Z.,Shang, W.,Yu, J.,Guo, H.,Liu, Q.,Wu, Y.,Peng, C.,Wang, J.,Zhu, C.,Yang, X.,Yang, K.,Lei, Y.,Guddat, L.W.,Xu, W.,Xiao, G.,Sun, L.,Zhang, L.,Rao, Z.,Yang, H. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein Cell 2021 12 877 888 7EB6 33830075 Crystal structure of GTP-binding protein-like domain of AGAP1 2021-03-09 2021-04-21 Cheng, N.,Zhang, H.,Zhang, S.,Ma, X.,Meng, G. Crystal structure of the GTP-binding protein-like domain of AGAP1. Acta Crystallogr.,Sect.F 2021 77 105 112 7KCF 33829783 Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AGI-24512 2020-10-05 2021-04-21 Konteatis, Z.,Travins, J.,Gross, S.,Marjon, K.,Barnett, A.,Mandley, E.,Nicolay, B.,Nagaraja, R.,Chen, Y.,Sun, Y.,Liu, Z.,Yu, J.,Ye, Z.,Jiang, F.,Wei, W.,Fang, C.,Gao, Y.,Kalev, P.,Hyer, M.L.,DeLaBarre, B.,Jin, L.,Padyana, A.K.,Dang, L.,Murtie, J.,Biller, S.A.,Sui, Z.,Marks, K.M. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J.Med.Chem. 2021 64 4430 4449 7KDA 33829783 Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 34 2020-10-08 2021-04-21 Konteatis, Z.,Travins, J.,Gross, S.,Marjon, K.,Barnett, A.,Mandley, E.,Nicolay, B.,Nagaraja, R.,Chen, Y.,Sun, Y.,Liu, Z.,Yu, J.,Ye, Z.,Jiang, F.,Wei, W.,Fang, C.,Gao, Y.,Kalev, P.,Hyer, M.L.,DeLaBarre, B.,Jin, L.,Padyana, A.K.,Dang, L.,Murtie, J.,Biller, S.A.,Sui, Z.,Marks, K.M. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J.Med.Chem. 2021 64 4430 4449 7KDB 33829783 Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 35 2020-10-08 2021-04-21 Konteatis, Z.,Travins, J.,Gross, S.,Marjon, K.,Barnett, A.,Mandley, E.,Nicolay, B.,Nagaraja, R.,Chen, Y.,Sun, Y.,Liu, Z.,Yu, J.,Ye, Z.,Jiang, F.,Wei, W.,Fang, C.,Gao, Y.,Kalev, P.,Hyer, M.L.,DeLaBarre, B.,Jin, L.,Padyana, A.K.,Dang, L.,Murtie, J.,Biller, S.A.,Sui, Z.,Marks, K.M. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J.Med.Chem. 2021 64 4430 4449 6LP3 Structural basis and functional analysis epo1-bem3p complex for bud growth 2020-01-08 2021-04-28 Wang, J. Structural basis and functional analysis epo1-bem3p complex for bud growth To Be Published 0 0 0 0 6LN0 33327866 Crystal structure of three main domains of nonstructural protein 3 from Coronavirus 2019-12-27 2021-05-05 Li, M.,Ye, G.,Si, Y.,Shen, Z.,Liu, Z.,Shi, Y.,Xiao, S.,Fu, Z.F.,Peng, G. Structure of the multiple functional domains from coronavirus nonstructural protein 3. Emerg Microbes Infect 2021 10 66 80 7C7I Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E) 2020-05-25 2021-05-05 Xu, X.L.,Liu, J.P.,Wang, Y.L.,Wang, Y.,Gong, X.,Pan, L.F. Mechanistic Insights into the Interactions of Ras Subfamily GTPases with the SPN Domain of Autism-associated SHANK3. Chin.J.Chem. 2020 38 1635 1641 7C7J Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E) 2020-05-25 2021-05-05 Xu, X.L.,Liu, J.P.,Wang, Y.L.,Wang, Y.,Gong, X.,Pan, L.F. Mechanistic Insights into the Interactions of Ras Subfamily GTPases with the SPN Domain of Autism-associated SHANK3. Chin.J.Chem. 2020 38 1635 1641 7DWM 33895551 Crystal structure of the phage VqmA-DPO complex 2021-01-17 2021-05-05 Gu, Y.,Zhi, S.X.,Yang, N.,Yang, W.S. Understanding the mechanism of asymmetric gene regulation determined by the VqmA of vibriophage. Biochem.Biophys.Res.Commun. 2021 558 51 56 6W44 33955740 Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 4 2020-03-10 2021-05-12 Lee, E.C.Y.,McRiner, A.J.,Georgiadis, K.E.,Liu, J.,Wang, Z.,Ferguson, A.D.,Levin, B.,von Rechenberg, M.,Hupp, C.D.,Monteiro, M.I.,Keefe, A.D.,Olszewski, A.,Eyermann, C.J.,Centrella, P.,Liu, Y.,Arora, S.,Cuozzo, J.W.,Zhang, Y.,Clark, M.A.,Huguet, C.,Kohlmann, A. Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. J.Med.Chem. 2021 64 6730 6744 6W4C 33955740 Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 5 2020-03-10 2021-05-12 Lee, E.C.Y.,McRiner, A.J.,Georgiadis, K.E.,Liu, J.,Wang, Z.,Ferguson, A.D.,Levin, B.,von Rechenberg, M.,Hupp, C.D.,Monteiro, M.I.,Keefe, A.D.,Olszewski, A.,Eyermann, C.J.,Centrella, P.,Liu, Y.,Arora, S.,Cuozzo, J.W.,Zhang, Y.,Clark, M.A.,Huguet, C.,Kohlmann, A. Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. J.Med.Chem. 2021 64 6730 6744 7C2X Crystal Structure of Glycyrrhiza uralensis UGT73P12 complexed with glycyrrhetinic acid 3-O-monoglucuronide 2020-05-09 2021-05-12 Ren, J.,Liu, M. Crystal Structure of Glycyrrhiza uralensis UGT73P12 complexed with glycyrrhetinic acid 3-O-monoglucuronide To Be Published 0 0 0 0 7C2Z 33820450 Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone 2020-05-10 2021-05-12 Li, J.,Zou, W.,Yu, K.,Liu, B.,Liang, W.,Wang, L.,Lu, Y.,Jiang, Z.,Wang, A.,Zhu, J. Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem 2021 36 903 913 7C6P 33820450 Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid 2020-05-22 2021-05-12 Li, J.,Zou, W.,Yu, K.,Liu, B.,Liang, W.,Wang, L.,Lu, Y.,Jiang, Z.,Wang, A.,Zhu, J. Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem 2021 36 903 913 7DHG 33990585 Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70 2020-11-14 2021-05-12 Gao, X.,Zhu, K.,Qin, B.,Olieric, V.,Wang, M.,Cui, S. Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions. Nat Commun 2021 12 2843 2843 7C3O Crystal structure of TT109 from CANDIDA ALBICANS 2020-05-13 2021-05-19 Chen, Y.P.,Lei, J.H.,Lu, D.R.,Su, D. Crystal structure of TT109 from CANDIDA ALBICANS To Be Published 0 0 0 0 7CHO 34244522 Crystal structure of SARS-CoV-2 antibody P5A-1D2 with RBD 2020-07-06 2021-05-19 Zhang, Q.,Ju, B.,Ge, J.,Chan, J.F.,Cheng, L.,Wang, R.,Huang, W.,Fang, M.,Chen, P.,Zhou, B.,Song, S.,Shan, S.,Yan, B.,Zhang, S.,Ge, X.,Yu, J.,Zhao, J.,Wang, H.,Liu, L.,Lv, Q.,Fu, L.,Shi, X.,Yuen, K.Y.,Liu, L.,Wang, Y.,Chen, Z.,Zhang, L.,Wang, X.,Zhang, Z. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun 2021 12 4210 4210 7CHP 34244522 Crystal structure of SARS-CoV-2 antibody P5A-3C8 with RBD 2020-07-06 2021-05-19 Zhang, Q.,Ju, B.,Ge, J.,Chan, J.F.,Cheng, L.,Wang, R.,Huang, W.,Fang, M.,Chen, P.,Zhou, B.,Song, S.,Shan, S.,Yan, B.,Zhang, S.,Ge, X.,Yu, J.,Zhao, J.,Wang, H.,Liu, L.,Lv, Q.,Fu, L.,Shi, X.,Yuen, K.Y.,Liu, L.,Wang, Y.,Chen, Z.,Zhang, L.,Wang, X.,Zhang, Z. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun 2021 12 4210 4210 7CHS 34244522 Crystal structure of SARS-CoV-2 antibody P22A-1D1 with RBD 2020-07-06 2021-05-19 Zhang, Q.,Ju, B.,Ge, J.,Chan, J.F.,Cheng, L.,Wang, R.,Huang, W.,Fang, M.,Chen, P.,Zhou, B.,Song, S.,Shan, S.,Yan, B.,Zhang, S.,Ge, X.,Yu, J.,Zhao, J.,Wang, H.,Liu, L.,Lv, Q.,Fu, L.,Shi, X.,Yuen, K.Y.,Liu, L.,Wang, Y.,Chen, Z.,Zhang, L.,Wang, X.,Zhang, Z. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun 2021 12 4210 4210 7D2L 34108490 Crystal structure of the Cas12i1 R-loop complex before target DNA cleavage 2020-09-16 2021-05-19 Zhang, B.,Luo, D.,Li, Y.,Perculija, V.,Chen, J.,Lin, J.,Ye, Y.,Ouyang, S. Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun 2021 12 3476 3476 7D3J 34108490 Crystal structure of the Cas12i1 R-loop complex after target DNA cleavage 2020-09-19 2021-05-19 Zhang, B.,Luo, D.,Li, Y.,Perculija, V.,Chen, J.,Lin, J.,Ye, Y.,Ouyang, S. Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun 2021 12 3476 3476 7D8C 34108490 Crystal structure of the Cas12i1-crRNA binary complex 2020-10-07 2021-05-19 Zhang, B.,Luo, D.,Li, Y.,Perculija, V.,Chen, J.,Lin, J.,Ye, Y.,Ouyang, S. Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun 2021 12 3476 3476 7E2W 33957092 Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with isocitrate and magnesium(II) 2021-02-07 2021-05-19 Tang, W.,Wu, M.,Qin, N.,Liu, L.,Meng, R.,Wang, C.,Wang, P.,Zang, J.,Zhu, G. Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs. Arch.Biochem.Biophys. 2021 708 108898 108898 7EPK Crystal Structure of Signal Recognition Particle 54 kDa protein (SRP54) from Aeropyrum pernix K1 in Complex with GDP 2021-04-27 2021-05-19 Xie, Y.,Zhang, B.,Liu, J. Crystal Structure of Signal Recognition Particle 54 kDa protein (SRP54) from Aeropyrum pernix K1 in Complex with GDP To be published 0 0 0 0 6X2Q Complex of Gynuella sunshinyii GH46 chitosanase GsCsn46A with chitotetraose 2020-05-20 2021-05-26 Qin, Z.,Wang, Y. Complex of Gynuella sunshinyii GH46 chitosanase GsCsn46A with chitotetraose To Be Published 0 0 0 0 7C6Q 34641558 Novel natural PPARalpha agonist with a unique binding mode 2020-05-22 2021-05-26 Tian, S.,Wang, R.,Chen, S.,He, J.,Zheng, W.,Li, Y. Structural Basis for PPARs Activation by The Dual PPAR alpha / gamma Agonist Sanguinarine: A Unique Mode of Ligand Recognition. Molecules 2021 26 0 0 7D8D The crystal structure of ScNTM1 in complex with SAH and Rps25a hexapeptide 2020-10-08 2021-05-26 Zhang, H.Y.,Kuang, Z.,Xue, L.,Yue, J.,Khan, M.H.,Zhu, Z.,Niu, L. Structural Basis for Peptide Binding of Alpha-N Terminal Methyltransferase from Saccharomyces cerevisiae Crystallography Reports 2021 66 1316 1321 7D8F The crystal structure of ScNTM1 in complex with SAH 2020-10-08 2021-05-26 Zhang, H.Y.,Kuang, Z.,Xue, L.,Yue, J.,Khan, M.H.,Zhu, Z.,Niu, L. Structural Basis for Peptide Binding of Alpha-N Terminal Methyltransferase from Saccharomyces cerevisiae Crystallography Reports 2021 66 1316 1321 7E8M 34166623 Crystal structure of SARS-CoV-2 antibody P2C-1F11 with mutated RBD 2021-03-02 2021-05-26 Wang, R.,Zhang, Q.,Ge, J.,Ren, W.,Zhang, R.,Lan, J.,Ju, B.,Su, B.,Yu, F.,Chen, P.,Liao, H.,Feng, Y.,Li, X.,Shi, X.,Zhang, Z.,Zhang, F.,Ding, Q.,Zhang, T.,Wang, X.,Zhang, L. Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species. Immunity 2021 54 1611 0 7EU9 34108490 Crystal structure of the selenomethionine(SeMet)-derived Cas12i1 R-loop complex before target DNA cleavage 2021-05-16 2021-05-26 Zhang, B.,Luo, D.,Li, Y.,Perculija, V.,Chen, J.,Lin, J.,Ye, Y.,Ouyang, S. Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun 2021 12 3476 3476 7DDY 34058201 Crystal structure of an acetyl xylan esterase AlAXEase 2020-10-30 2021-06-02 Zhang, Y.,Ding, H.T.,Jiang, W.X.,Zhang, X.,Cao, H.Y.,Wang, J.P.,Li, C.Y.,Huang, F.,Zhang, X.Y.,Chen, X.L.,Zhang, Y.Z.,Li, P.Y. Active site architecture of an acetyl xylan esterase indicates a novel cold adaptation strategy. J.Biol.Chem. 2021 297 100841 100841 6LWA 34226550 Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing 5-hydroxyuracil (5-OHU) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWB 34226550 Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing 5-hydroxyuracil (5-OHU) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWD 34226550 Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing spiroiminodihydantoin (Sp) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWG 34226550 Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing guanidinohydantoin (Gh) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWH 34226550 Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrothymine (DHT) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWI 34226550 Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing dihydrothymine (DHT) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWJ 34226550 Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrouracil (DHU) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWK 34226550 Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing dihydrouracil (DHU) 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWL 34226550 Crystal structure of human NEIL1(R242) bound to duplex DNA containing 2'-fluoro-2'-deoxy-5,6-dihydrouridine 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWM 34226550 Crystal structure of human NEIL1(K242) bound to duplex DNA containing 2'-fluoro-2'-deoxy-5,6-dihydrouridine 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWN 34226550 Crystal structure of human NEIL1(R242, G249P) bound to duplex DNA containing 2'-fluoro-2'-deoxy-5,6-dihydrouridine 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWO 34226550 Crystal structure of human NEIL1(R242, Y244H) bound to duplex DNA containing 2'-fluoro-2'-deoxy-5,6-dihydrouridine 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWP 34226550 Crystal structure of human NEIL1(R242, Y244R) bound to duplex DNA containing 2'-fluoro-2'-deoxy-5,6-dihydrouridine 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 6LWQ 34226550 Crystal structure of human NEIL1(R242) bound to duplex DNA containing a C:T mismatch 2020-02-07 2021-06-09 Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun 2021 12 4108 4108 7C91 33371681 Blasnase-T13A with D-asn 2020-06-04 2021-06-09 Ran, T.,Jiao, L.,Wang, W.,Chen, J.,Chi, H.,Lu, Z.,Zhang, C.,Xu, D.,Lu, F. Structures of l-asparaginase from Bacillus licheniformis Reveal an Essential Residue for its Substrate Stereoselectivity. J.Agric.Food Chem. 2021 69 223 231 7C9Q Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP 2020-06-07 2021-06-09 Huang, Y.,Li, R.,Wan, J. Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP To Be Published 0 0 0 0 7CB4 33371681 Crystal structures of of BlAsnase 2020-06-10 2021-06-09 Ran, T.,Jiao, L.,Wang, W.,Chen, J.,Chi, H.,Lu, Z.,Zhang, C.,Xu, D.,Lu, F. Structures of l-asparaginase from Bacillus licheniformis Reveal an Essential Residue for its Substrate Stereoselectivity. J.Agric.Food Chem. 2021 69 223 231 7CQZ 34048638 crystal structure of mouse FAM46C (TENT5C) 2020-08-12 2021-06-09 Zhang, H.,Zhang, S.H.,Hu, J.L.,Wu, Y.T.,Ma, X.Y.,Chen, Y.,Yu, B.,Liao, S.,Huang, H.,Gao, S. Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. Cancer Commun (Lond) 2021 41 615 630 7CS2 33990581 Apo structure of dimeric IiPLR1 2020-08-14 2021-06-09 Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun 2021 12 2828 2828 7CS3 33990581 IiPLR1 with NADP+ 2020-08-14 2021-06-09 Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun 2021 12 2828 2828 7CS4 33990581 IiPLR1 with NADP+ and (+)pinoresinol 2020-08-14 2021-06-09 Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun 2021 12 2828 2828 7CS5 33990581 IiPLR1 with NADP+ and (-)pinoresinol 2020-08-14 2021-06-09 Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun 2021 12 2828 2828 7CS6 33990581 IiPLR1 with NADP+ and (-)lariciresinol 2020-08-14 2021-06-09 Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun 2021 12 2828 2828 7CS7 33990581 IiPLR1 with NADP+ and (+)secoisolariciresinol 2020-08-14 2021-06-09 Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun 2021 12 2828 2828 7CS8 33990581 IiPLR1 with NADP+ and (-)secoisolariciresinol 2020-08-14 2021-06-09 Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nat Commun 2021 12 2828 2828 7D55 33609147 Crystal structure of lys170 CBD 2020-09-25 2021-06-09 Xu, X.,Zhang, D.,Zhou, B.,Zhen, X.,Ouyang, S. Structural and biochemical analyses of the tetrameric cell binding domain of Lys170 from enterococcal phage F170/08. Eur.Biophys.J. 2021 50 721 729 7DH8 34048589 Crystal structure of holo XcZur 2020-11-13 2021-06-09 Liu, F.,Su, Z.,Chen, P.,Tian, X.,Wu, L.,Tang, D.J.,Li, P.,Deng, H.,Ding, P.,Fu, Q.,Tang, J.L.,Ming, Z. Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator. Nucleic Acids Res. 2021 49 6511 6528 7E7X 34021265 SARS-CoV-2 Spike Protein N terminal domain in Complex with N11 Fab 2021-02-28 2021-06-09 Cao, Y.,Yisimayi, A.,Bai, Y.,Huang, W.,Li, X.,Zhang, Z.,Yuan, T.,An, R.,Wang, J.,Xiao, T.,Du, S.,Ma, W.,Song, L.,Li, Y.,Li, X.,Song, W.,Wu, J.,Liu, S.,Li, X.,Zhang, Y.,Su, B.,Guo, X.,Wei, Y.,Gao, C.,Zhang, N.,Zhang, Y.,Dou, Y.,Xu, X.,Shi, R.,Lu, B.,Jin, R.,Ma, Y.,Qin, C.,Wang, Y.,Feng, Y.,Xiao, J.,Xie, X.S. Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines. Cell Res. 2021 31 732 741 7ECG 34048588 Crystal Structure of d(G4C2)2-Ba in F222 space group 2021-03-12 2021-06-09 Geng, Y.,Liu, C.,Cai, Q.,Luo, Z.,Miao, H.,Shi, X.,Xu, N.,Fung, C.P.,Choy, T.T.,Yan, B.,Li, N.,Qian, P.,Zhou, B.,Zhu, G. Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence. Nucleic Acids Res. 2021 49 5881 5890 7ECH 34048588 Crystal Structure of d(G4C2)2-K in F222 space group 2021-03-12 2021-06-09 Geng, Y.,Liu, C.,Cai, Q.,Luo, Z.,Miao, H.,Shi, X.,Xu, N.,Fung, C.P.,Choy, T.T.,Yan, B.,Li, N.,Qian, P.,Zhou, B.,Zhu, G. Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence. Nucleic Acids Res. 2021 49 5881 5890 7EL4 The crystal structure of p53p peptide fragment in complex with the N-terminal domain of MdmX 2021-04-08 2021-06-09 Cheng, X.Y.,Zhang, B.L.,Li, Z.C.,Kuang, Z.K.,Su, Z.D. The crystal structure of the N-terminal domain of MdmX in complex with p53p peptide fragment To Be Published 0 0 0 0 7EQ4 34132580 Crystal Structure of the N-terminus of Nonstructural protein 1 from SARS-CoV-2 2021-04-29 2021-06-09 Zhao, K.,Ke, Z.,Hu, H.,Liu, Y.,Li, A.,Hua, R.,Guo, F.,Xiao, J.,Zhang, Y.,Duan, L.,Yan, X.F.,Gao, Y.G.,Liu, B.,Xia, Y.,Li, Y. Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1. Microbiol Spectr 2021 9 0 0 7CB2 The 6-phosphogluconate dehydrogenase (NADP-bound) from Staphylococcus aureus 2020-06-10 2021-06-16 Wang, H.,Wang, M.,Sun, H. The 6-phosphogluconate dehydrogenase (NADP-bound) structures from Staphylococcus aureus To Be Published 0 0 0 0 7CQ2 34181713 Crystal structure of Slx1-Slx4 2020-08-08 2021-06-16 Xu, X.,Wang, M.,Sun, J.,Yu, Z.,Li, G.,Yang, N.,Xu, R.M. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. Nucleic Acids Res. 2021 49 7740 7752 7CQ3 34181713 Crystal structure of Slx1-Slx4 2020-08-08 2021-06-16 Xu, X.,Wang, M.,Sun, J.,Yu, Z.,Li, G.,Yang, N.,Xu, R.M. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. Nucleic Acids Res. 2021 49 7740 7752 7CQ4 34181713 Crystal structure of Slx1-Slx4 in complex with 5'flap DNA 2020-08-08 2021-06-16 Xu, X.,Wang, M.,Sun, J.,Yu, Z.,Li, G.,Yang, N.,Xu, R.M. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex. Nucleic Acids Res. 2021 49 7740 7752 7DC6 33078460 Giant panda MHC class I complexes 2020-10-23 2021-06-16 Yuan, H.,Ma, L.,Zhang, L.,Li, X.,Xia, C. Crystal structure of the giant panda MHC class I complex: First insights into the viral peptide presentation profile in the bear family. Protein Sci. 2020 29 2468 2481 7DLX 34038732 crystal structure of H2AM4>Z-H2B 2020-11-30 2021-06-16 Dai, L.,Xiao, X.,Pan, L.,Shi, L.,Xu, N.,Zhang, Z.,Feng, X.,Ma, L.,Dou, S.,Wang, P.,Zhu, B.,Li, W.,Zhou, Z. Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange. Cell Rep 2021 35 109183 109183 7DRG 33838074 Pseudomonas aeruginosa T6SS protein PA0821 2020-12-28 2021-06-16 Wang, S.,Geng, Z.,Zhang, H.,She, Z.,Dong, Y. The Pseudomonas aeruginosa PAAR2 cluster encodes a putative VRR-NUC domain-containing effector. Febs J. 2021 288 5755 5767 7EXM 34398430 The N-terminal crystal structure of SARS-CoV-2 NSP2 2021-05-27 2021-06-16 Ma, J.,Chen, Y.,Wu, W.,Chen, Z. Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2. Virol Sin 2021 36 1104 1112 7EYX Crystal structure of Mg-free KRAS-G12D bound to GDP 2021-06-01 2021-06-16 Fei, Z. Crystal structure of Mg-free KRAS-G12D bound to GDP To Be Published 0 0 0 0 6XFQ Structure of a novel antithrombotic agent Agkisacucetin in complex with the platelet glycoprotein Ib receptor 2020-06-16 2021-06-23 Wang, J.,Gao, Y.X.,Ke, J.Y.,Zhu, Z.L.,Niu, L.W. Structure of a novel antithrombotic agent Agkisacucetin in complex with the platelet glycoprotein Ib receptor To be published 0 0 0 0 7CUT 34075025 Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with Z-VAD-FMK 2020-08-24 2021-06-23 Wang, Z.,Zhao, Y.,Wang, Q.,Xing, Y.,Feng, L.,Kong, J.,Peng, C.,Zhang, L.,Yang, H.,Lu, M. Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M pro . Signal Transduct Target Ther 2021 6 214 214 7E5Y 34315862 Molecular basis for neutralizing antibody 2B11 targeting SARS-CoV-2 RBD 2021-02-21 2021-06-23 Pan, Y.,Du, J.,Liu, J.,Wu, H.,Gui, F.,Zhang, N.,Deng, X.,Song, G.,Li, Y.,Lu, J.,Wu, X.,Zhan, S.,Jing, Z.,Wang, J.,Yang, Y.,Liu, J.,Chen, Y.,Chen, Q.,Zhang, H.,Hu, H.,Duan, K.,Wang, M.,Wang, Q.,Yang, X. Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries. Cell Discov 2021 7 57 57 7CF8 34597996 PfkB(Mycobacterium marinum) 2020-06-24 2021-06-30 Gao, B.,Ji, R.,Li, Z.,Su, X.,Li, H.,Sun, Y.,Ji, C.,Gan, J.,Li, J. Structural analysis and functional study of phosphofructokinase B (PfkB) from Mycobacterium marinum. Biochem.Biophys.Res.Commun. 2021 579 129 135 7CFU Crystal Structure of FMN-dependent Cysteine Decarboxylases SpaF 2020-06-28 2021-06-30 Lu, J.,Li, J.,Zhu, J.,Wang, H. Characterization of FMN-dependent Cysteine Decarboxylases SPAF To Be Published 0 0 0 0 7CG8 Structure of the sensor domain (short construct) of the anti-sigma factor RsgI4 in Pseudobacteroides cellulosolvens 2020-06-30 2021-06-30 Dong, S.,Chen, C.,Feng, Y. Structure of the sensor domain of the anti-sigma factor RsgI4 in Pseudobacteroides cellulosolvens To Be Published 0 0 0 0 7CO6 34145298 Binary complex of DNA polymerase Mu with 1-nt gapped DNA (templating thymine) 2020-08-04 2021-06-30 Guo, M.,Wang, Y.,Tang, Y.,Chen, Z.,Hou, J.,Dai, J.,Wang, Y.,Wang, L.,Xu, H.,Tian, B.,Hua, Y.,Zhao, Y. Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun 2021 12 3759 3759 7CO8 34145298 Ternary complex of DNA polymerase Mu with 2-nt gapped DNA (T:dGMPNPP) 2020-08-04 2021-06-30 Guo, M.,Wang, Y.,Tang, Y.,Chen, Z.,Hou, J.,Dai, J.,Wang, Y.,Wang, L.,Xu, H.,Tian, B.,Hua, Y.,Zhao, Y. Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun 2021 12 3759 3759 7CO9 34145298 Ternary complex of DNA polymerase Mu with 1-nt gapped DNA (T:dGMPNPP) and Mg 2020-08-04 2021-06-30 Guo, M.,Wang, Y.,Tang, Y.,Chen, Z.,Hou, J.,Dai, J.,Wang, Y.,Wang, L.,Xu, H.,Tian, B.,Hua, Y.,Zhao, Y. Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun 2021 12 3759 3759 7COA 34145298 Ternary complex of DNA polymerase Mu with 1-nt gapped DNA (T:dGMPNPP) and Mn 2020-08-04 2021-06-30 Guo, M.,Wang, Y.,Tang, Y.,Chen, Z.,Hou, J.,Dai, J.,Wang, Y.,Wang, L.,Xu, H.,Tian, B.,Hua, Y.,Zhao, Y. Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun 2021 12 3759 3759 7COB 34145298 Ternary complex of DNA polymerase Mu (Q441A) with 1-nt gapped DNA (T:dGMPNPP) 2020-08-04 2021-06-30 Guo, M.,Wang, Y.,Tang, Y.,Chen, Z.,Hou, J.,Dai, J.,Wang, Y.,Wang, L.,Xu, H.,Tian, B.,Hua, Y.,Zhao, Y. Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun 2021 12 3759 3759 7COC 34145298 Ternary complex of DNA polymerase Mu (K438A/Q441A) with 1-nt gapped DNA (T:dGMPNPP) 2020-08-04 2021-06-30 Guo, M.,Wang, Y.,Tang, Y.,Chen, Z.,Hou, J.,Dai, J.,Wang, Y.,Wang, L.,Xu, H.,Tian, B.,Hua, Y.,Zhao, Y. Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun 2021 12 3759 3759 7COD 34145298 Post insertion complex of DNA polymerase Mu (K438A/Q441A) with 1-nt gapped DNA 2020-08-04 2021-06-30 Guo, M.,Wang, Y.,Tang, Y.,Chen, Z.,Hou, J.,Dai, J.,Wang, Y.,Wang, L.,Xu, H.,Tian, B.,Hua, Y.,Zhao, Y. Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun 2021 12 3759 3759 7ELX The crystal structure of CTLA-4 and Fab 2021-04-12 2021-06-30 Yu, X.J.,Yu, C.F. The crystal structure of CTLA-4 and Fab To Be Published 0 0 0 0 7N7L 34001596 Crystal Structure of PI5P4KIIAlpha complex with BI-D1870 2021-06-10 2021-06-30 Chen, S.,Chandra Tjin, C.,Gao, X.,Xue, Y.,Jiao, H.,Zhang, R.,Wu, M.,He, Z.,Ellman, J.,Ha, Y. Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA 2021 118 0 0 6LO2 Crystal structure of EED in complex with EZH2 peptide and compound 11# 2020-01-02 2021-07-07 Zhao, K.,Zhao, M.,Luo, X.,Zhang, H. Structure of EED in complex with EZH2 peptide and cmpd20 To Be Published 0 0 0 0 7CG2 Vigna radiata Epoxide hydrolase mutant 2020-06-30 2021-07-07 Li, F.L.,Qiu, Y.Y.,Zheng, Y.C.,Chen, F.F.,Kong, X.D.,Xu, J.H.,Yu, H.L. Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds Adv.Synth.Catal. 2021 362 4699 4706 7CG6 Vigna radiata Epoxide hydrolase mutant M263Q 2020-06-30 2021-07-07 Li, F.L.,Qiu, Y.Y.,Zheng, Y.C.,Chen, F.F.,Kong, X.D.,Xu, J.H.,Yu, H.L. Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds Adv.Synth.Catal. 2021 362 4699 4706 7D0R 34259319 Crystal structure of human HBO1-BRPF2 in complex with crotonoyl-coenzyme A 2020-09-11 2021-07-07 Xiao, Y.,Li, W.,Yang, H.,Pan, L.,Zhang, L.,Lu, L.,Chen, J.,Wei, W.,Ye, J.,Li, J.,Li, G.,Zhang, Y.,Tan, M.,Ding, J.,Wong, J. HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic Acids Res. 2021 49 8037 8059 7D0S 34259319 Crystal structure of human HBO1-BRPF2 in complex with succinyl-coenzyme A 2020-09-11 2021-07-07 Xiao, Y.,Li, W.,Yang, H.,Pan, L.,Zhang, L.,Lu, L.,Chen, J.,Wei, W.,Ye, J.,Li, J.,Li, G.,Zhang, Y.,Tan, M.,Ding, J.,Wong, J. HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic Acids Res. 2021 49 8037 8059 7DWN 34081954 Crystal structure of Vibrio fischeri DarR in complex with DNA reveals the transcriptional activation mechanism of LTTR family members 2021-01-17 2021-07-07 Wang, W.,Wu, H.,Xiao, Q.,Zhou, H.,Li, M.,Xu, Q.,Wang, Q.,Yu, F.,He, J. Crystal structure details of Vibrio fischeri DarR and mutant DarR-M202I from LTTR family reveals their activation mechanism. Int.J.Biol.Macromol. 2021 183 2354 2363 7DWO 34081954 Crystal structure of Vibrio fischeri DarR in complex with DNA reveals the transcriptional activation mechanism of LTTR family members 2021-01-17 2021-07-07 Wang, W.,Wu, H.,Xiao, Q.,Zhou, H.,Li, M.,Xu, Q.,Wang, Q.,Yu, F.,He, J. Crystal structure details of Vibrio fischeri DarR and mutant DarR-M202I from LTTR family reveals their activation mechanism. Int.J.Biol.Macromol. 2021 183 2354 2363 7E7A Crystal structure of apo ENL YEATS domain T3 mutant 2021-02-25 2021-07-07 Li, Y.,Li, H. Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27 To Be Published 0 0 0 0 7EIN 34579576 SARS-CoV-2 main proteinase complex with microbial metabolite leupeptin 2021-03-31 2021-07-07 Fu, L.,Shao, S.,Feng, Y.,Ye, F.,Sun, X.,Wang, Q.,Yu, F.,Wang, Q.,Huang, B.,Niu, P.,Li, X.,Wong, C.C.L.,Qi, J.,Tan, W.,Gao, G.F. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. Mbio 2021 12 0 0 7F49 32011054 von Willebrand factor (VWF) A1 domain with BT-100 aptamer RNA 2021-06-18 2021-07-07 Zhu, S.,Gilbert, C.J. The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer J Thromb Haemost. 2020 18 1113 1123 7CIP Microbial Hormone-sensitive lipase E53 wild type 2020-07-08 2021-07-14 Yang, X. Microbial Hormone-sensitive lipase E53 wild type To Be Published 0 0 0 0 7CJB VHL recognizes hydroxyproline in RIPK1 2020-07-09 2021-07-14 Liu, J.,Wang, Y.,Pan, L. VHL recognizes hydroxyproline in RIPK1 To Be Published 0 0 0 0 7CJK Complex structure of AtHPPD with inhibitor Y18093 2020-07-11 2021-07-14 Lin, H.Y.,Yang, G.F. Complex structure of AtHPPD with inhibitor Y18093 To Be Published 0 0 0 0 7CJX UDP-glucuronosyltransferase 2B15 C-terminal domain-L446S 2020-07-14 2021-07-14 Wang, C.Y.,Zhang, L. Structure of UDP-glucuronosyltransferase 2B15 C-terminal domain L446S at 1.99 Angstroms resolution To Be Published 0 0 0 0 7CJY Drimenol synthase from Persicaria hydropiper 2020-07-14 2021-07-14 Xiao, W.,Zhou, H.,Zhou, M.T.,Liu, L.,Xiang, Z. Structural and Biochemical Studies of Drimenol Synthase from Persicaria hydropiper To Be Published 0 0 0 0 7CQT 33340324 Crystal structure of Brassica juncea HMG-CoA synthase 1 mutant - S359A in complex with acetyl-CoA 2020-08-11 2021-07-14 Liao, P.,Lung, S.C.,Chan, W.L.,Hu, M.,Kong, G.K.,Bach, T.J.,Hao, Q.,Lo, C.,Chye, M.L. Overexpression and Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA Synthase Affect Central Metabolic Pathways in Tobacco. Plant Cell.Physiol. 2021 62 205 218 7DCI Crystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientation 2020-10-26 2021-07-14 Wei, L.,Wei, L. Crystal structure of HSF2 DNA-binding domain in complex with 2-site HSE DNA in the head-to-head orientation To Be Published 0 0 0 0 7DCT 34458700 Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (24 bp) 2020-10-27 2021-07-14 Feng, N.,Feng, H.,Wang, S.,Punekar, A.S.,Ladenstein, R.,Wang, D.C.,Zhang, Q.,Ding, J.,Liu, W. Structures of heat shock factor trimers bound to DNA. Iscience 2021 24 102951 102951 7E7E 34404805 The co-crystal structure of ACE2 with Fab 2021-02-26 2021-07-14 Du, Y.,Shi, R.,Zhang, Y.,Duan, X.,Li, L.,Zhang, J.,Wang, F.,Zhang, R.,Shen, H.,Wang, Y.,Wu, Z.,Peng, Q.,Pan, T.,Sun, W.,Huang, W.,Feng, Y.,Feng, H.,Xiao, J.,Tan, W.,Wang, Y.,Wang, C.,Yan, J. A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants. Nat Commun 2021 12 5000 5000 7EH1 34187896 Thermus thermophilus transcription initiation complex containing a template-strand purine at position TSS-2, GpG RNA primer, and CMPcPP 2021-03-27 2021-07-14 Skalenko, K.S.,Li, L.,Zhang, Y.,Vvedenskaya, I.O.,Winkelman, J.T.,Cope, A.L.,Taylor, D.M.,Shah, P.,Ebright, R.H.,Kinney, J.B.,Zhang, Y.,Nickels, B.E. Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA 2021 118 0 0 7EH2 34187896 Thermus thermophilus transcription initiation complex containing a template-strand pyrimidine at position TSS-2 and GpG RNA primer 2021-03-27 2021-07-14 Skalenko, K.S.,Li, L.,Zhang, Y.,Vvedenskaya, I.O.,Winkelman, J.T.,Cope, A.L.,Taylor, D.M.,Shah, P.,Ebright, R.H.,Kinney, J.B.,Zhang, Y.,Nickels, B.E. Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA 2021 118 0 0 7EP0 34214466 Crystal structure of ZYG11B bound to GSTE degron 2021-04-26 2021-07-14 Yan, X.,Li, Y.,Wang, G.,Zhou, Z.,Song, G.,Feng, Q.,Zhao, Y.,Mi, W.,Ma, Z.,Dong, C. Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell 2021 81 3262 0 7EP1 34214466 Crystal structure of ZYG11B bound to GFLH degron 2021-04-26 2021-07-14 Yan, X.,Li, Y.,Wang, G.,Zhou, Z.,Song, G.,Feng, Q.,Zhao, Y.,Mi, W.,Ma, Z.,Dong, C. Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell 2021 81 3262 0 7EP3 34214466 Crystal structure of ZER1 bound to GAGN degron 2021-04-26 2021-07-14 Yan, X.,Li, Y.,Wang, G.,Zhou, Z.,Song, G.,Feng, Q.,Zhao, Y.,Mi, W.,Ma, Z.,Dong, C. Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell 2021 81 3262 0 7EP4 34214466 Crystal structure of ZER1 bound to GFLH degron 2021-04-26 2021-07-14 Yan, X.,Li, Y.,Wang, G.,Zhou, Z.,Song, G.,Feng, Q.,Zhao, Y.,Mi, W.,Ma, Z.,Dong, C. Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell 2021 81 3262 0 7EP5 34214466 Crystal structure of ZER1 bound to GKLH degron 2021-04-26 2021-07-14 Yan, X.,Li, Y.,Wang, G.,Zhou, Z.,Song, G.,Feng, Q.,Zhao, Y.,Mi, W.,Ma, Z.,Dong, C. Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell 2021 81 3262 0 7EPU 34210977 Crystal structure of HsALC1 2021-04-27 2021-07-14 Wang, L.,Chen, K.,Chen, Z. Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nat Commun 2021 12 4057 4057 7CKK 33910046 Structural complex of FTO bound with Dac51 2020-07-17 2021-07-21 Liu, Y.,Liang, G.,Xu, H.,Dong, W.,Dong, Z.,Qiu, Z.,Zhang, Z.,Li, F.,Huang, Y.,Li, Y.,Wu, J.,Yin, S.,Zhang, Y.,Guo, P.,Liu, J.,Xi, J.J.,Jiang, P.,Han, D.,Yang, C.G.,Xu, M.M. Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab. 2021 33 1221 0 7F09 34225079 Crystal structure of the HLH-Lz domain of human TFE3 2021-06-03 2021-07-21 Yang, G.,Li, P.,Liu, Z.,Wu, S.,Zhuang, C.,Qiao, H.,Zheng, L.,Fang, P.,Lei, C.,Wang, J. Structural basis for the dimerization mechanism of human transcription factor E3. Biochem.Biophys.Res.Commun. 2021 569 41 46 7MWL The TAM domain of BAZ2A in complex with a 12mer mCG DNA 2021-05-17 2021-07-21 Liu, K.,Dong, A.,Li, Y.,Loppnau, P.,Edwards, A.M.,Arrowsmith, C.H.,Min, J.,Structural Genomics Consortium (SGC) The TAM domain of BAZ2A in complex with a 12mer mCG DNA To Be Published 0 0 0 0 7CLF PigF with SAH 2020-07-20 2021-07-28 Qiu, S.,Xu, D.,Xu, M.,Zhou, H.,Sun, N.,Zhang, L.,Zhao, M.,He, J.,Ran, T.,Sun, B.,Wang, W. Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism. Iucrj 2022 9 316 327 7CLU PigF with SAH 2020-07-22 2021-07-28 Qiu, S.,Xu, D.,Xu, M.,Zhou, H.,Sun, N.,Zhang, L.,Zhao, M.,He, J.,Ran, T.,Sun, B.,Wang, W. Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism. Iucrj 2022 9 316 327 7D86 34365506 Crystal Structure of zebrafishPHF14-PZP 2020-10-07 2021-07-28 Zheng, S.,Bi, Y.,Chen, H.,Gong, B.,Jia, S.,Li, H. Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14. Nucleic Acids Res. 2021 49 8961 8973 7D87 34365506 Crystal Structure of zebrafish PHF14-PZP in complex with H3(1-25) 2020-10-07 2021-07-28 Zheng, S.,Bi, Y.,Chen, H.,Gong, B.,Jia, S.,Li, H. Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14. Nucleic Acids Res. 2021 49 8961 8973 7D8A 34365506 Crystal Structure of H3(1-13)/PHF14-PZP fusion protein 2020-10-07 2021-07-28 Zheng, S.,Bi, Y.,Chen, H.,Gong, B.,Jia, S.,Li, H. Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14. Nucleic Acids Res. 2021 49 8961 8973 7DFC 33888704 Crystal of Arrestin2-V2Rpp-3-Fab30 complex 2020-11-06 2021-07-28 He, Q.T.,Xiao, P.,Huang, S.M.,Jia, Y.L.,Zhu, Z.L.,Lin, J.Y.,Yang, F.,Tao, X.N.,Zhao, R.J.,Gao, F.Y.,Niu, X.G.,Xiao, K.H.,Wang, J.,Jin, C.,Sun, J.P.,Yu, X. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun 2021 12 2396 2396 7E44 34074215 Crystal structure of NudC complexed with dpCoA 2021-02-10 2021-07-28 Zhou, W.,Guan, Z.,Zhao, F.,Ye, Y.,Yang, F.,Yin, P.,Zhang, D. Structural insights into dpCoA-RNA decapping by NudC. Rna Biol. 2021 18 244 253 7E76 33774822 The structure of chloroplastic TaPGI 2021-02-25 2021-07-28 Gao, F.,Zhang, H.,Zhang, W.,Wang, N.,Zhang, S.,Chu, C.,Liu, C. Engineering of the cytosolic form of phosphoglucose isomerase into chloroplasts improves plant photosynthesis and biomass. New Phytol. 2021 231 315 325 7E77 33774822 The structure of cytosolic TaPGI 2021-02-25 2021-07-28 Gao, F.,Zhang, H.,Zhang, W.,Wang, N.,Zhang, S.,Chu, C.,Liu, C. Engineering of the cytosolic form of phosphoglucose isomerase into chloroplasts improves plant photosynthesis and biomass. New Phytol. 2021 231 315 325 7E78 33774822 the structure of cytosolic TaPGI with substrate 2021-02-25 2021-07-28 Gao, F.,Zhang, H.,Zhang, W.,Wang, N.,Zhang, S.,Chu, C.,Liu, C. Engineering of the cytosolic form of phosphoglucose isomerase into chloroplasts improves plant photosynthesis and biomass. New Phytol. 2021 231 315 325 7EXS 35124004 Thermomicrobium roseum sarcosine oxidase mutant - S320R 2021-05-28 2021-07-28 Xin, Y.,Shen, C.,Tang, M.,Guo, Z.,Shi, Y.,Gu, Z.,Shao, J.,Zhang, L. Recreating the natural evolutionary trend in key microdomains provides an effective strategy for engineering of a thermomicrobial N-demethylase. J.Biol.Chem. 2022 298 101656 101656 7FCA 34597996 PfkB(Mycobacterium marinum) 2021-07-14 2021-08-04 Gao, B.,Ji, R.,Li, Z.,Su, X.,Li, H.,Sun, Y.,Ji, C.,Gan, J.,Li, J. Structural analysis and functional study of phosphofructokinase B (PfkB) from Mycobacterium marinum. Biochem.Biophys.Res.Commun. 2021 579 129 135 7CP3 Crystal Structure of PAK4 in complex with inhibitor 47 2020-08-05 2021-08-11 Song, P.,Zhao, F.,Cheng, M. Discovery of 6-ethynyl-1H-indole-3-carboxamide Derivatives as Highly Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors to be published 0 0 0 0 7CQO Lysozyme grown in LCP soaked with selenourea for 6 min 2020-08-11 2021-08-11 Luo, Z.P.,Gu, W.,Wang, Y.,Tang, Y.,Li, D.F. Selenourea for experimental phasing of membrane protein crystals grown in lipid cubic phase Crystals 2022 12 0 0 7CRN The Functional Characterization and Crystal Structure of the Bifunctional Thioesterase Catalyzing Epimerization and Cyclization 2020-08-14 2021-08-18 Yu, J.,Juan, S.,Chi, C.,Liu, T.,Geng, T.,Cai, Z.,Dong, W.,Shi, C.,Ma, X.,Zhang, Z.,Ma, X.,Xing, B.,Jin, H.,Zhang, L.,Dong, S.,Yang, D.,Ma, M. Functional Characterization and Crystal Structure of the Bifunctional Thioesterase Catalyzing Epimerization and Cyclization in Skyllamycin Biosynthesis Acs Catalysis 2021 11 11733 11741 7F9K 34433057 Crystal structure of the variable region of Plasmodium RIFIN #6(PF3D7_1400600) 2021-07-04 2021-08-18 Xie, Y.,Li, X.,Chai, Y.,Song, H.,Qi, J.,Gao, G.F. Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1. Cell Rep 2021 36 109600 109600 7F9L 34433057 Crystal structure of the variable region of Plasmodium RIFIN #6 (PF3D7_1400600) in complex with LAIR1 (with T67L, N69S and A77T mutations) 2021-07-04 2021-08-18 Xie, Y.,Li, X.,Chai, Y.,Song, H.,Qi, J.,Gao, G.F. Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1. Cell Rep 2021 36 109600 109600 7F9N 34433057 Crystal structure of the variable region of Plasmodium RIFIN #4 (PF3D7_1000500) in complex with LAIR1 2021-07-04 2021-08-18 Xie, Y.,Li, X.,Chai, Y.,Song, H.,Qi, J.,Gao, G.F. Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1. Cell Rep 2021 36 109600 109600 7CT1 Crystal structure of Snx27 FERM domain in complex with a DLF motif 2020-08-17 2021-08-25 Hu, W.,Jia, D.,Sun, Q. Crystal structure of Snx27 FERM domain in complex with a DLF motif To Be Published 0 0 0 0 7CU8 34417177 Crystal structure of the soluble domain of TiME protein from Mycobacterium tuberculosis 2020-08-21 2021-08-25 Cai, X.,Liu, L.,Qiu, C.,Wen, C.,He, Y.,Cui, Y.,Li, S.,Zhang, X.,Zhang, L.,Tian, C.,Bi, L.,Zhou, Z.H.,Gong, W. Identification and architecture of a putative secretion tube across mycobacterial outer envelope. Sci Adv 2021 7 0 0 7CU9 34417177 Crystal structure of the soluble domain of TiME protein from Mycobacterium smegmatis 2020-08-21 2021-08-25 Cai, X.,Liu, L.,Qiu, C.,Wen, C.,He, Y.,Cui, Y.,Li, S.,Zhang, X.,Zhang, L.,Tian, C.,Bi, L.,Zhou, Z.H.,Gong, W. Identification and architecture of a putative secretion tube across mycobacterial outer envelope. Sci Adv 2021 7 0 0 7D9O 33570950 Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 2 2020-10-14 2021-08-25 Zhou, Y.,Fu, Y.,Yin, W.,Li, J.,Wang, W.,Bai, F.,Xu, S.,Gong, Q.,Peng, T.,Hong, Y.,Zhang, D.,Zhang, D.,Liu, Q.,Xu, Y.,Xu, H.E.,Zhang, H.,Jiang, H.,Liu, H. Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate. J.Med.Chem. 2021 64 1844 1855 7D9Q 33570950 Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 7 2020-10-14 2021-08-25 Zhou, Y.,Fu, Y.,Yin, W.,Li, J.,Wang, W.,Bai, F.,Xu, S.,Gong, Q.,Peng, T.,Hong, Y.,Zhang, D.,Zhang, D.,Liu, Q.,Xu, Y.,Xu, H.E.,Zhang, H.,Jiang, H.,Liu, H. Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate. J.Med.Chem. 2021 64 1844 1855 7DC3 34345217 Crystal structure of the MyRF ICA domain 2020-10-23 2021-08-25 Wu, P.,Zhen, X.,Li, B.,Yu, Q.,Huang, X.,Shi, N. Crystal structure of the MyRF ICA domain with its upstream beta-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage. Int J Biol Sci 2021 17 2931 2943 7DYM 34371041 Pseudomonas aeruginosa TseT-TsiT complex 2021-01-22 2021-08-25 Wen, H.,Liu, G.,Geng, Z.,Zhang, H.,Li, Y.,She, Z.,Dong, Y. Structure and SAXS studies unveiled a novel inhibition mechanism of the Pseudomonas aeruginosa T6SS TseT-TsiT complex. Int.J.Biol.Macromol. 2021 188 450 459 7E2R 34382282 The ligand-free structure of Arabidopsis thaliana GUN4 2021-02-07 2021-08-25 Hu, J.H.,Chang, J.W.,Xu, T.,Wang, J.,Wang, X.,Lin, R.,Duanmu, D.,Liu, L. Structural basis of bilin binding by the chlorophyll biosynthesis regulator GUN4. Protein Sci. 2021 30 2083 2091 7E56 34043362 The mutant crystal structure of endo-polygalacturonase (T316C/G344C) from Talaromyces leycettanus JCM 12802 2021-02-17 2021-08-25 Wang, S.,Meng, K.,Su, X.,Hakulinen, N.,Wang, Y.,Zhang, J.,Luo, H.,Yao, B.,Huang, H.,Tu, T. Cysteine Engineering of an Endo-polygalacturonase from Talaromyces leycettanus JCM 12802 to Improve Its Thermostability. J.Agric.Food Chem. 2021 69 6351 6359 7CV9 RNA methyltransferase METTL4 2020-08-25 2021-09-01 Luo, Q.,Mo, J.,Chen, H.,Hu, Z.,Wang, B.,Wu, J.,Liang, Z.,Xie, W.,Du, K.,Peng, M.,Li, Y.,Li, T.,Zhang, Y.,Shi, X.,Shen, W.H.,Shi, Y.,Dong, A.,Wang, H.,Ma, J. Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4 Nat Commun 2022 13 5636 0 7FE0 35922406 AvmM Catalyzes Macrocyclization in Alchivemycin A Biosynthesis 2021-07-19 2021-09-01 Zhu, H.J.,Zhang, B.,Wei, W.,Liu, S.H.,Xiang, L.,Zhu, J.,Jiao, R.H.,Igarashi, Y.,Bashiri, G.,Liang, Y.,Tan, R.X.,Ge, H.M. AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis. Nat Commun 2022 13 4499 4499 7FE5 35922406 AvmM Catalyzes Macrocyclization in Alchivemycin A Biosynthesis 2021-07-19 2021-09-01 Zhu, H.J.,Zhang, B.,Wei, W.,Liu, S.H.,Xiang, L.,Zhu, J.,Jiao, R.H.,Igarashi, Y.,Bashiri, G.,Liang, Y.,Tan, R.X.,Ge, H.M. AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis. Nat Commun 2022 13 4499 4499 7DHS 33654218 Crystal Structure Analysis of the BRD4 2020-11-17 2021-09-15 Wu, T.B.,Xiang, Q.P.,Wang, C.,Wu, C.,Zhang, C.,Zhang, M.F.,Liu, Z.X.,Zhang, Y.,Xiao, L.J.,Xu, Y. Y06014 is a selective BET inhibitor for the treatment of prostate cancer. Acta Pharmacol.Sin. 2021 42 2120 2131 7CDW 34540889 Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1 2020-06-20 2021-09-22 Gao, X.,Yu, X.,Zhu, K.,Qin, B.,Wang, W.,Han, P.,Aleksandra Wojdyla, J.,Wang, M.,Cui, S. Crystal Structure of Mycobacterium tuberculosis Elongation Factor G1. Front Mol Biosci 2021 8 667638 667638 7D2F 33450485 Lp major histidine acid phosphatase mutant D281A/5'-AMP 2020-09-16 2021-09-22 Guo, Y.,Zhou, D.,Zhang, H.,Zhang, N.N.,Qi, X.,Chen, X.,Chen, Q.,Li, J.,Ge, H.,Teng, Y.B. Structural insights into a new substrate binding mode of a histidine acid phosphatase from Legionella pneumophila. Biochem.Biophys.Res.Commun. 2021 540 90 94 7D31 35013452 The TBA-Pb2+ complex in P41212 space group 2020-09-18 2021-09-22 Liu, H.,Gao, Y.,Mathivanan, J.,Shen, F.,Chen, X.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Sheng, J.,Gan, J. Structure-guided development of Pb 2+ -binding DNA aptamers. Sci Rep 2022 12 460 460 7DO4 33992645 Crystal structure of CD97-CD55 complex 2020-12-11 2021-09-22 Niu, M.,Xu, S.,Yang, J.,Yao, D.,Li, N.,Yan, J.,Zhong, G.,Song, G. Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs. J.Biol.Chem. 2021 296 100776 100776 7DBG 33890470 Yeast CRM1e (apo) in complex with Ran-RanBP1 2020-10-20 2021-09-29 Lei, Y.,Li, Y.,Tan, Y.,Qian, Z.,Zhou, Q.,Jia, D.,Sun, Q. Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod. 2021 84 1478 1488 7DHX Crystal structure of SARS-CoV-2 RBD binding to pangolin ACE2 2020-11-17 2021-09-29 Wu, L.,Gao, G.,Yan, J.,Wang, Q.,Niu, S.,Chen, Q.,Qi, J.,Zhang, Y.,Jiaqi, S.,Shi, Y. Molecular basis of pangolin ACE2 engaged by COVID-19 virus Chin.Sci.Bull. 2021 66 73 84 7DLW 34757795 Crystal structure of Arabidopsis ACS7 in complex with PPG 2020-11-30 2021-09-29 Xu, C.,Hao, B.,Sun, G.,Mei, Y.,Sun, L.,Sun, Y.,Wang, Y.,Zhang, Y.,Zhang, W.,Zhang, M.,Zhang, Y.,Wang, D.,Rao, Z.,Li, X.,Shen, Q.J.,Wang, N.N. Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes. Sci Adv 2021 7 0 0 7DLY 34757795 Crystal structure of Arabidopsis ACS7 mutant in complex with PPG 2020-11-30 2021-09-29 Xu, C.,Hao, B.,Sun, G.,Mei, Y.,Sun, L.,Sun, Y.,Wang, Y.,Zhang, Y.,Zhang, W.,Zhang, M.,Zhang, Y.,Wang, D.,Rao, Z.,Li, X.,Shen, Q.J.,Wang, N.N. Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes. Sci Adv 2021 7 0 0 7DQZ 34586857 Crystal structure of SARS 3C-like protease in apo form 2020-12-24 2021-09-29 Zhang, Y.,Gao, H.,Hu, X.,Wang, Q.,Zhong, F.,Zhou, X.,Lin, C.,Yang, Y.,Wei, J.,Du, W.,Huang, H.,Zhou, H.,He, W.,Zhang, H.,Zhang, Y.,McCormick, P.J.,Fu, J.,Wang, D.,Fu, Y.,Lu, X.,Zhang, T.,Duan, J.,Qin, B.,Jiang, H.,Luo, J.,Zhang, Y.,Chen, Q.,Luo, Q.,Cheng, L.,Zhang, Z.,Zhang, J.,Li, J. Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol. 2022 96 0 0 7E24 Crystal structure of SDR family NAD(P)-dependent oxidoreductase from Exiguobacterium 2021-02-04 2021-09-29 Tang, J.,Chen, L.,Zhang, L.,Ni, G.,Yu, J.,Wang, H.,Zhang, F.,Yuan, S.,Feng, M.,Che, S. Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technolo 2021 0 0 0 7E57 34551288 Crystal structure of murine GITR-GITRL complex 2021-02-18 2021-09-29 Zhao, M.,Fu, L.,Chai, Y.,Sun, M.,Li, Y.,Wang, S.,Qi, J.,Zeng, B.,Kang, L.,Gao, G.F.,Tan, S. Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation. Cell Rep 2021 36 109734 109734 7EBS 34562453 Crystal structure of juvenile hormone acid methyltransferase JHAMT from silkworm 2021-03-11 2021-09-29 Guo, P.,Zhang, Y.,Zhang, L.,Xu, H.,Zhang, H.,Wang, Z.,Jiang, Y.,Molloy, D.,Zhao, P.,Xia, Q. Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase. J.Biol.Chem. 2021 297 101234 101234 7EBX 34562453 Crystal structure of juvenile hormone acid methyltransferase JHAMT in complex with S-adenosyl-L-homocysteine. 2021-03-11 2021-09-29 Guo, P.,Zhang, Y.,Zhang, L.,Xu, H.,Zhang, H.,Wang, Z.,Jiang, Y.,Molloy, D.,Zhao, P.,Xia, Q. Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase. J.Biol.Chem. 2021 297 101234 101234 7EC0 34562453 Crystal structure of juvenile hormone acid methyltransferase JHAMT in complex with S-Adenosyl homocysteine and methyl farnesoate 2021-03-11 2021-09-29 Guo, P.,Zhang, Y.,Zhang, L.,Xu, H.,Zhang, H.,Wang, Z.,Jiang, Y.,Molloy, D.,Zhao, P.,Xia, Q. Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase. J.Biol.Chem. 2021 297 101234 101234 7EQL 34917113 Crystal structure of (+)-pulegone reductase from Mentha piperita 2021-05-03 2021-09-29 Liu, C.,Gao, Q.,Shang, Z.,Liu, J.,Zhou, S.,Dang, J.,Liu, L.,Lange, I.,Srividya, N.,Lange, B.M.,Wu, Q.,Lin, W. Functional Characterization and Structural Insights Into Stereoselectivity of Pulegone Reductase in Menthol Biosynthesis. Front Plant Sci 2021 12 780970 780970 7PI4 34416073 FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB 2021-08-19 2021-09-29 Law, R.P.,Nunes, J.,Chung, C.W.,Bantscheff, M.,Buda, K.,Dai, H.,Evans, J.P.,Flinders, A.,Klimaszewska, D.,Lewis, A.J.,Muelbaier, M.,Scott-Stevens, P.,Stacey, P.,Tame, C.J.,Watt, G.F.,Zinn, N.,Queisser, M.A.,Harling, J.D.,Benowitz, A.B. Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs. Angew.Chem.Int.Ed.Engl. 2021 60 23327 23334 6LN1 34323401 A natural inhibitor of DYRK1A for treatment of diabetes mellitus 2019-12-28 2021-10-06 Zheng, M.,Zhang, Q.,Zhang, C.,Wu, C.,Yang, K.,Song, Z.,Wang, Q.,Li, C.,Zhou, Y.,Chen, J.,Li, H.,Chen, L. A natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes. Clin Transl Med 2021 11 0 0 7BSX 34873166 SDR protein NapW-NADP 2020-03-31 2021-10-06 Wen, W.H.,Zhang, Y.,Zhang, Y.Y.,Yu, Q.,Jiang, C.C.,Tang, M.C.,Pu, J.Y.,Wu, L.,Zhao, Y.L.,Shi, T.,Zhou, J.,Tang, G.L. Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. Nat Commun 2021 12 7085 7085 7D3Y 35332155 Crystal structure of the osPHR2-osSPX2 complex 2020-09-21 2021-10-06 Guan, Z.,Zhang, Q.,Zhang, Z.,Zuo, J.,Chen, J.,Liu, R.,Savarin, J.,Broger, L.,Cheng, P.,Wang, Q.,Pei, K.,Zhang, D.,Zou, T.,Yan, J.,Yin, P.,Hothorn, M.,Liu, Z. Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 - PHR2 complex. Nat Commun 2022 13 1581 1581 7E4M Class I Pimarane-Type Diterpene Synthases Stt4548 2021-02-14 2021-10-06 Xing, B.,Yu, J.,Chi, C.,Ma, X.,Xu, Q.,Li, A.,Ge, Y.,Wang, Z.,Liu, T.,Jia, H.,Yin, F.,Guo, J.,Huang, L.,Yang, D.,Ma, M. Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis Commun Chem 2021 4 140 0 7E4N Crystal structure of Sat1646 2021-02-14 2021-10-06 Xing, B.,Yu, J.,Chi, C.,Ma, X.,Xu, Q.,Li, A.,Ge, Y.,Wang, Z.,Liu, T.,Jia, H.,Yin, F.,Guo, J.,Huang, L.,Yang, D.,Ma, M. Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis Commun Chem 2021 4 140 0 7E6L 34605439 Crystal structure of HCoV-NL63 3C-like protease,pH5.0 2021-02-22 2021-10-06 Gao, H.,Zhang, Y.,Jiang, H.,Hu, X.,Zhang, Y.,Zhou, X.,Zhong, F.,Lin, C.,Li, J.,Luo, J.,Zhang, J. Crystal structures of human coronavirus NL63 main protease at different pH values Acta Crystallogr.,Sect.F 2021 77 348 355 7E6M 34605439 Crystal structure of Human coronavirus NL63 3C-like protease 2021-02-22 2021-10-06 Gao, H.,Zhang, Y.,Jiang, H.,Hu, X.,Zhang, Y.,Zhou, X.,Zhong, F.,Lin, C.,Li, J.,Luo, J.,Zhang, J. Crystal structures of human coronavirus NL63 main protease at different pH values Acta Crystallogr.,Sect.F 2021 77 348 355 7E6N 34605439 Crystal structure of HCoV-NL63 3C-like protease,pH5.2 2021-02-22 2021-10-06 Gao, H.,Zhang, Y.,Jiang, H.,Hu, X.,Zhang, Y.,Zhou, X.,Zhong, F.,Lin, C.,Li, J.,Luo, J.,Zhang, J. Crystal structures of human coronavirus NL63 main protease at different pH values Acta Crystallogr.,Sect.F 2021 77 348 355 7E6R 34605439 Crystal structure of HCoV-NL63 3C-like protease,pH5.6 2021-02-23 2021-10-06 Gao, H.,Zhang, Y.,Jiang, H.,Hu, X.,Zhang, Y.,Zhou, X.,Zhong, F.,Lin, C.,Li, J.,Luo, J.,Zhang, J. Crystal structures of human coronavirus NL63 main protease at different pH values Acta Crystallogr.,Sect.F 2021 77 348 355 7D57 C-Src in complex with FIIN-2 2020-09-25 2021-10-13 Qu, L.,Chen, X.,Wei, H.,Guo, M.,Dai, S.,Jiang, L.,Li, J.,Yue, S.,Chen, Z.,Chen, Y. Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors Commun Chem 2022 5 5 0 7D6I A neutralizing MAb targeting receptor-binding-domain of SARS-CoV-2 2020-09-30 2021-10-13 Shi, R.,Qi, J.X.,Gao, G.F.,Yan, J.H. A neutralizing MAb targeting receptor-binding-domain of SARS-CoV-2 To Be Published 0 0 0 0 7D8V 34843479 Crystal Structure of A Kinesin-3 KIF13B mutant-T192Y 2020-10-10 2021-10-13 Cong, D.Z.,Ren, J.Q.,Zhou, Y.R.,Wang, S.,Liang, J.J.,Ding, M.,Feng, W. Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A. Plos Genet. 2021 17 0 0 7VKM 34625502 Crystal structure of TrkA (G595R) kinase domain 2021-09-30 2021-10-13 Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A. Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther. 2021 20 2446 2456 7D5Z Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8 2020-09-28 2021-10-20 Zhu, Q.,Shan, S.,Yu, J.,Wang, X.,Zhang, L.,Zeng, M. A Neutralizing Antibody Targeting a New Site of Vulnerability on Epstein-Barr Virus gH/gL Protects against Dual-Tropic Infection To Be Published 0 0 0 0 7DV8 34702740 The crystal structure of rice immune receptor RGA5-HMA2. 2021-01-12 2021-10-20 Liu, Y.,Zhang, X.,Yuan, G.,Wang, D.,Zheng, Y.,Ma, M.,Guo, L.,Bhadauria, V.,Peng, Y.L.,Liu, J. A designer rice NLR immune receptor confers resistance to the rice blast fungus carrying noncorresponding avirulence effectors. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7EEA 34727518 Cyanophage Pam1 tailspike receptor-binding domain 2021-03-18 2021-10-20 Zhang, J.T.,Yang, F.,Du, K.,Li, W.F.,Chen, Y.,Jiang, Y.L.,Li, Q.,Zhou, C.Z. Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1. Structure 2022 30 240 0 7EO7 34586857 Crystal structure of HCoV-NL63 3C-like protease in complex with an inhibitor Shikonin 2021-04-21 2021-10-20 Zhang, Y.,Gao, H.,Hu, X.,Wang, Q.,Zhong, F.,Zhou, X.,Lin, C.,Yang, Y.,Wei, J.,Du, W.,Huang, H.,Zhou, H.,He, W.,Zhang, H.,Zhang, Y.,McCormick, P.J.,Fu, J.,Wang, D.,Fu, Y.,Lu, X.,Zhang, T.,Duan, J.,Qin, B.,Jiang, H.,Luo, J.,Zhang, Y.,Chen, Q.,Luo, Q.,Cheng, L.,Zhang, Z.,Zhang, J.,Li, J. Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol. 2022 96 0 0 7EO8 34586857 Crystal structure of SARS coronavirus main protease in complex with an inhibitor Shikonin 2021-04-21 2021-10-20 Zhang, Y.,Gao, H.,Hu, X.,Wang, Q.,Zhong, F.,Zhou, X.,Lin, C.,Yang, Y.,Wei, J.,Du, W.,Huang, H.,Zhou, H.,He, W.,Zhang, H.,Zhang, Y.,McCormick, P.J.,Fu, J.,Wang, D.,Fu, Y.,Lu, X.,Zhang, T.,Duan, J.,Qin, B.,Jiang, H.,Luo, J.,Zhang, Y.,Chen, Q.,Luo, Q.,Cheng, L.,Zhang, Z.,Zhang, J.,Li, J. Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol. 2022 96 0 0 7EP9 34866611 The structure of carboxypeptidase from Fusobacterium nucleatum 2021-04-26 2021-10-27 Wang, X.,Cheng, M.T.,Chen, Z.P.,Jiang, Y.L.,Ge, Y.S.,Xia, R.,Hou, W.T. Structural and biochemical analyses of the tetrameric carboxypeptidase S9Cfn from Fusobacterium nucleatum. Acta Crystallogr D Struct Biol 2021 77 1554 1563 7D3C 23549610 The newly emerged SARS-like coronavirus HCoV-EMC also has an ""Achilles' heel"": current effective inhibitor targeting a 3C-like protease 2020-09-18 2021-11-03 Ren, Z.,Yan, L.,Zhang, N.,Guo, Y.,Yang, C.,Lou, Z.,Rao, Z. The newly emerged SARS-like coronavirus HCoV-EMC also has an ""Achilles' heel"": current effective inhibitor targeting a 3C-like protease Protein cell 2013 4 248 250 7DAT The crystal structure of COVID-19 main protease treated by AF 2020-10-18 2021-11-03 He, Z.,Ye, F.,Zhang, C.,Fan, J.,Du, Z.,Zhao, W.,Yuan, Q.,Niu, W.,Gao, F.,He, B.,Cao, P.,Zhao, L.,Gao, X.,Gao, X.,Sun, B.,Dong, Y.,Zhao, J.,Qi, J.,Liang, X.J.,Jiang, H.,Gong, Y.,Tan, W.,Gao, X. A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster. Nano Today 2022 44 101468 0 7DCM 36593274 Crystal structure of CITX 2020-10-26 2021-11-03 Cheng, Y.,Wang, H.,Xu, H.,Liu, Y.,Ma, B.,Chen, X.,Zeng, X.,Wang, X.,Wang, B.,Shiau, C.,Ovchinnikov, S.,Su, X.D.,Wang, C. Co-evolution-based prediction of metal-binding sites in proteomes by machine learning. Nat.Chem.Biol. 2023 19 548 555 7DCN 36593274 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase 2020-10-26 2021-11-03 Cheng, Y.,Wang, H.,Xu, H.,Liu, Y.,Ma, B.,Chen, X.,Zeng, X.,Wang, X.,Wang, B.,Shiau, C.,Ovchinnikov, S.,Su, X.D.,Wang, C. Co-evolution-based prediction of metal-binding sites in proteomes by machine learning. Nat.Chem.Biol. 2023 19 548 555 7DEA Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck Northern China/22/2017 (H5N6) 2020-11-03 2021-11-03 Sun, H.,Sun, H.,Song, J.,Zhang, W.,Qi, J.,Gao, G.F.,Liu, J. Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals To Be Published 0 0 0 0 7DEB Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck/Eastern China/L0230/2010 (H5N2) 2020-11-03 2021-11-03 Sun, H.,Sun, H.,Song, J.,Zhang, W.,Qi, J.,Gao, G.F.,Liu, J. Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals To Be Published 0 0 0 0 7EKC 34671049 Structure of SARS-CoV-2 Gamma variant spike receptor-binding domain complexed with human ACE2 2021-04-05 2021-11-03 Han, P.,Su, C.,Zhang, Y.,Bai, C.,Zheng, A.,Qiao, C.,Wang, Q.,Niu, S.,Chen, Q.,Zhang, Y.,Li, W.,Liao, H.,Li, J.,Zhang, Z.,Cho, H.,Yang, M.,Rong, X.,Hu, Y.,Huang, N.,Yan, J.,Wang, Q.,Zhao, X.,Gao, G.F.,Qi, J. Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants. Nat Commun 2021 12 6103 6103 7EKE 34671049 Structure of SARS-CoV-2 spike receptor-binding domain F486L mutation complexed with human ACE2 2021-04-05 2021-11-03 Han, P.,Su, C.,Zhang, Y.,Bai, C.,Zheng, A.,Qiao, C.,Wang, Q.,Niu, S.,Chen, Q.,Zhang, Y.,Li, W.,Liao, H.,Li, J.,Zhang, Z.,Cho, H.,Yang, M.,Rong, X.,Hu, Y.,Huang, N.,Yan, J.,Wang, Q.,Zhao, X.,Gao, G.F.,Qi, J. Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants. Nat Commun 2021 12 6103 6103 7EKF 34671049 Structure of SARS-CoV-2 Alpha variant spike receptor-binding domain complexed with human ACE2 2021-04-05 2021-11-03 Han, P.,Su, C.,Zhang, Y.,Bai, C.,Zheng, A.,Qiao, C.,Wang, Q.,Niu, S.,Chen, Q.,Zhang, Y.,Li, W.,Liao, H.,Li, J.,Zhang, Z.,Cho, H.,Yang, M.,Rong, X.,Hu, Y.,Huang, N.,Yan, J.,Wang, Q.,Zhao, X.,Gao, G.F.,Qi, J. Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants. Nat Commun 2021 12 6103 6103 7EKG 34671049 Structure of SARS-CoV-2 Beta variant spike receptor-binding domain complexed with human ACE2 2021-04-05 2021-11-03 Han, P.,Su, C.,Zhang, Y.,Bai, C.,Zheng, A.,Qiao, C.,Wang, Q.,Niu, S.,Chen, Q.,Zhang, Y.,Li, W.,Liao, H.,Li, J.,Zhang, Z.,Cho, H.,Yang, M.,Rong, X.,Hu, Y.,Huang, N.,Yan, J.,Wang, Q.,Zhao, X.,Gao, G.F.,Qi, J. Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants. Nat Commun 2021 12 6103 6103 7EKH 34671049 Structure of SARS-CoV-2 spike receptor-binding domain Y453F mutation complexed with human ACE2 2021-04-05 2021-11-03 Han, P.,Su, C.,Zhang, Y.,Bai, C.,Zheng, A.,Qiao, C.,Wang, Q.,Niu, S.,Chen, Q.,Zhang, Y.,Li, W.,Liao, H.,Li, J.,Zhang, Z.,Cho, H.,Yang, M.,Rong, X.,Hu, Y.,Huang, N.,Yan, J.,Wang, Q.,Zhao, X.,Gao, G.F.,Qi, J. Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants. Nat Commun 2021 12 6103 6103 7F1N 34659150 Beta-Glucosidase 2021-06-09 2021-11-03 Chen, A.,Wang, D.,Ji, R.,Li, J.,Gu, S.,Tang, R.,Ji, C. Structural and Catalytic Characterization of TsBGL, a beta-Glucosidase From Thermofilum sp. ex4484_79. Front Microbiol 2021 12 723678 723678 7VMU 35581593 Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody 2021-10-09 2021-11-03 Li, L.,Gao, M.,Jiao, P.,Zu, S.,Deng, Y.Q.,Wan, D.,Cao, Y.,Duan, J.,Aliyari, S.R.,Li, J.,Shi, Y.,Rao, Z.,Qin, C.F.,Guo, Y.,Cheng, G.,Yang, H. Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants. Cell Biosci 2022 12 63 63 7DG4 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 6 2020-11-10 2021-11-10 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7E40 34857773 Mechanism of Phosphate Sensing and Signaling Revealed by Rice SPX1-PHR2 Complex Structure 2021-02-09 2021-11-10 Zhou, J.,Hu, Q.,Xiao, X.,Yao, D.,Ge, S.,Ye, J.,Li, H.,Cai, R.,Liu, R.,Meng, F.,Wang, C.,Zhu, J.K.,Lei, M.,Xing, W. Mechanism of phosphate sensing and signaling revealed by rice SPX1-PHR2 complex structure. Nat Commun 2021 12 7040 7040 7EIM 34726181 Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W470A) in complex with maltopentaose 2021-03-31 2021-11-10 Shen, M.,Gong, X.,Xiang, S. Crystal structures of glycogen-debranching enzyme mutants in complex with oligosaccharides. Acta Crystallogr.,Sect.F 2021 77 420 426 7EJP 34726181 Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W470A) in complex with maltohexaose 2021-04-02 2021-11-10 Shen, M.,Gong, X.,Xiang, S. Crystal structures of glycogen-debranching enzyme mutants in complex with oligosaccharides. Acta Crystallogr.,Sect.F 2021 77 420 426 7EJT 34726181 Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W470A) in complex with maltoheptaose 2021-04-02 2021-11-10 Shen, M.,Gong, X.,Xiang, S. Crystal structures of glycogen-debranching enzyme mutants in complex with oligosaccharides. Acta Crystallogr.,Sect.F 2021 77 420 426 7EKW 34726181 Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (D535N) in complex with maltotetrose 2021-04-07 2021-11-10 Shen, M.,Gong, X.,Xiang, S. Crystal structures of glycogen-debranching enzyme mutants in complex with oligosaccharides. Acta Crystallogr.,Sect.F 2021 77 420 426 7EKX 34726181 Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W470A E564Q) in complex with maltononaose 2021-04-07 2021-11-10 Shen, M.,Gong, X.,Xiang, S. Crystal structures of glycogen-debranching enzyme mutants in complex with oligosaccharides. Acta Crystallogr.,Sect.F 2021 77 420 426 7EPV 34895224 Crystal structure of tigecycline degrading monooxygenase Tet(X4) 2021-04-27 2021-11-10 Cheng, Q.,Cheung, Y.,Liu, C.,Xiao, Q.,Sun, B.,Zhou, J.,Chan, E.W.C.,Zhang, R.,Chen, S. Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. Bmc Biol. 2021 19 262 262 7EPW 34895224 Crystal structure of monooxygenase Tet(X4) with tigecycline 2021-04-28 2021-11-10 Cheng, Q.,Cheung, Y.,Liu, C.,Xiao, Q.,Sun, B.,Zhou, J.,Chan, E.W.C.,Zhang, R.,Chen, S. Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. Bmc Biol. 2021 19 262 262 7EV8 34730394 Structure of Human Parainfluenza Virus 3 Unassembled Nucleoprotein in Complex with its viral chaperone 2021-05-20 2021-11-10 Dong, X.,Wang, X.,Xie, M.,Wu, W.,Chen, Z. Structural Basis of Human Parainfluenza Virus 3 Unassembled Nucleoprotein in Complex with Its Viral Chaperone. J.Virol. 2022 96 0 0 7CRU 34689235 hnRNPK NLS in complex with Importin alpha 1 (KPNA2) 2020-08-14 2021-11-17 Yao, J.,Tu, Y.,Shen, C.,Zhou, Q.,Xiao, H.,Jia, D.,Sun, Q. Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN. Cell.Mol.Life Sci. 2021 78 7617 7633 7D9I 34741591 SpdH Spermidine dehydrogenase D282A mutant 2020-10-13 2021-11-17 Che, S.,Liang, Y.,Chen, Y.,Wu, W.,Liu, R.,Zhang, Q.,Bartlam, M. Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold. Febs J. 2022 289 1911 1928 7DFX Structure and function of Diadenylate cyclase DacM in Mycoplasma ovipneumoniae 2020-11-10 2021-11-17 Li, M.,Fan, S. Structure and function of Diadenylate cyclase DacM in Mycoplasma ovipneumoniae To Be Published 0 0 0 0 7DG0 Structure and function of Diadenylate cyclase DacM in Mycoplasma ovipneumoniae 2020-11-10 2021-11-17 Li, M.,Fan, S.L. Structure and function of Diadenylate cyclase DacM in Mycoplasma ovipneumoniae To Be Published 0 0 0 0 7DH3 The co-crystal structure of DYRK2 with a small molecule inhibitor 5 2020-11-12 2021-11-17 Wei, T.,Xiao, J. The co-crystal structure of DYRK2 with a small molecule inhibitor 5 To Be Published 0 0 0 0 7DH9 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 7 2020-11-13 2021-11-17 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DHC 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 10 2020-11-13 2021-11-17 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DHH 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 19 2020-11-14 2021-11-17 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DHK 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 13 2020-11-16 2021-11-17 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DHN 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 20 2020-11-16 2021-11-17 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DHO 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 14 2020-11-16 2021-11-17 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DHV 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 8 2020-11-17 2021-11-17 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DU0 34432044 Structure of an type I-F anti-crispr protein 2021-01-07 2021-11-17 Liu, X.,Zhang, L.,Xiu, Y.,Gao, T.,Huang, L.,Xie, Y.,Yang, L.,Wang, W.,Wang, P.,Zhang, Y.,Yang, M.,Feng, Y. Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex. Nucleic Acids Res. 2021 49 10178 10191 7DJO 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 17 2020-11-20 2021-11-24 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7DSY Crystal Structure of RNase L in complex with KM05073 2021-01-03 2021-11-24 Tang, J.,Dong, B.,Liu, M.,Liu, S.,Niu, X.,Gaughan, C.,Asthana, A.,Zhou, H.,Xu, Z.,Zhang, G.,Silverman, R.H.,Huang, H. Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem. 2022 65 1445 1457 7DTS Crystal structure of RNase L in complex with AC40357 2021-01-06 2021-11-24 Tang, J.,Dong, B.,Liu, M.,Liu, S.,Niu, X.,Gaughan, C.,Asthana, A.,Zhou, H.,Xu, Z.,Zhang, G.,Silverman, R.H.,Huang, H. Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery J.Med.Chem. 2022 65 1445 1457 7FAI 34781683 CARM1 bound with compound 9 2021-07-06 2021-11-24 Zhang, Z.,Guo, Z.,Xu, X.,Cao, D.,Yang, H.,Li, Y.,Shi, Q.,Du, Z.,Guo, X.,Wang, X.,Chen, D.,Zhang, Y.,Chen, L.,Zhou, K.,Li, J.,Geng, M.,Huang, X.,Xiong, B. Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy. J.Med.Chem. 2021 64 16650 16674 7FAJ 34781683 CARM1 bound with compound 43 2021-07-06 2021-11-24 Zhang, Z.,Guo, Z.,Xu, X.,Cao, D.,Yang, H.,Li, Y.,Shi, Q.,Du, Z.,Guo, X.,Wang, X.,Chen, D.,Zhang, Y.,Chen, L.,Zhou, K.,Li, J.,Geng, M.,Huang, X.,Xiong, B. Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy. J.Med.Chem. 2021 64 16650 16674 7VNB 34732694 Crystal structure of the SARS-CoV-2 RBD in complex with a human single domain antibody n3113 2021-10-10 2021-11-24 Yang, Z.,Wang, Y.,Jin, Y.,Zhu, Y.,Wu, Y.,Li, C.,Kong, Y.,Song, W.,Tian, X.,Zhan, W.,Huang, A.,Zhou, S.,Xia, S.,Tian, X.,Peng, C.,Chen, C.,Shi, Y.,Hu, G.,Du, S.,Wang, Y.,Xie, Y.,Jiang, S.,Lu, L.,Sun, L.,Song, Y.,Ying, T. A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants. Signal Transduct Target Ther 2021 6 378 378 7VUP 36779700 Structure of NF-kB p52 homodimer bound to +1/-1 swap P-Selectin kB DNA fragment 2021-11-04 2021-11-24 Pan, W.,Meshcheryakov, V.A.,Li, T.,Wang, Y.,Ghosh, G.,Wang, V.Y. Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation. Elife 2023 12 0 0 7VUQ 36779700 Structure of NF-kB p52 homodimer bound to A/T-centric P-Selectin kB DNA fragment 2021-11-04 2021-11-24 Pan, W.,Meshcheryakov, V.A.,Li, T.,Wang, Y.,Ghosh, G.,Wang, V.Y. Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation. Elife 2023 12 0 0 7DL6 35439114 The co-crystal structure of DYRK2 with a small molecule inhibitor 18 2020-11-26 2021-12-01 Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife 2022 11 0 0 7E2V Crystal structure of MaDA-3 2021-02-07 2021-12-01 Gao, L.,Zou, Y.,Liu, X.,Yang, J.,Du, X.,Wang, J.,Yu, X.,Fan, J.,Jiang, M.,Li, Y.,Houk, K.N.,Lei, X. Enzymatic control of endo- and exo-stereoselective Diels-Alder reactions with broad substrate scope. Nat Catal 2021 0 0 0 7CYR 34956144 The closed conformation of MSMEG_1954 from Mycobacterium smegmatis 2020-09-04 2021-12-08 Zhang, Q.,Liu, X.,Liu, H.,Zhang, B.,Yang, H.,Mi, K.,Guddat, L.W.,Rao, Z. Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding. Front Microbiol 2021 12 780954 780954 7DMS A Fe(II)-binding effector of Yersinia pseudotuberculosis 2020-12-07 2021-12-08 Ouyang, S.,Hongxin, G. A Fe(II)-binding effector of Yersinia pseudotuberculosis To Be Published 0 0 0 0 7E0X 34542283 Crystal structure of Arabidopsis thaliana HPPD complexed with 4-hydroxyphenylacetic acid 2021-01-28 2021-12-08 Lin, H.Y.,Chen, X.,Dong, J.,Yang, J.F.,Xiao, H.,Ye, Y.,Li, L.H.,Zhan, C.G.,Yang, W.C.,Yang, G.F. Rational Redesign of Enzyme via the Combination of Quantum Mechanics/Molecular Mechanics, Molecular Dynamics, and Structural Biology Study. J.Am.Chem.Soc. 2021 143 15674 15687 7CRE 34689235 hnRNPK KH3 domain in complex with a ssDNA fragment from the SIRLOIN element 2020-08-13 2021-12-15 Yao, J.,Tu, Y.,Shen, C.,Zhou, Q.,Xiao, H.,Jia, D.,Sun, Q. Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN. Cell.Mol.Life Sci. 2021 78 7617 7633 7DM0 Biofilm associated protein - C region 2020-12-01 2021-12-15 Ma, J.F.,Fang, X.Y. Biofilm associated protein - C region To Be Published 0 0 0 0 7DNR Crystal Structure of Zn-bound SIS Domain of Glucosamine-6-P Synthase from E. coli 2020-12-10 2021-12-15 Zeng, X.,Wei, T.,Liu, Y.,Wang, X.,Feng, T.,Cheng, Y.,Qin, W.,Gao, C.,Xiao, J.,Wang, C. Discovery of Metal-binding Proteins by Thermal Proteome Profiling To Be Published 0 0 0 0 7E5M 34693228 crystal structure of trans assembled human TROP-2 2021-02-19 2021-12-15 Sun, M.,Zhang, H.,Jiang, M.,Chai, Y.,Qi, J.,Gao, G.F.,Tan, S. Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2. Iscience 2021 24 103190 103190 7E5N 34693228 crystal structure of cis assembled TROP-2 2021-02-19 2021-12-15 Sun, M.,Zhang, H.,Jiang, M.,Chai, Y.,Qi, J.,Gao, G.F.,Tan, S. Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2. Iscience 2021 24 103190 103190 7V6W 34861238 Crystal structure of heterohexameric Sa2YoeB-Sa2YefM complex bound to 26bp-DNA 2021-08-20 2021-12-15 Xue, L.,Khan, M.H.,Yue, J.,Zhu, Z.,Niu, L. The two paralogous copies of the YoeB-YefM toxin-antitoxin module in Staphylococcus aureus differ in DNA binding and recognition patterns. J.Biol.Chem. 2022 298 101457 101457 7VSW 35174992 Crystal structure of a Fab-like fragment of anti-mesothelin antibody 2021-10-27 2021-12-15 Wang, C.,Hong, J.,Yang, Z.,Zhou, X.,Yang, Y.,Kong, Y.,Chen, B.,Wu, H.,Qian, B.Z.,Dimitrov, D.S.,Zhou, X.,Wu, Y.,Ying, T. Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use. Small Methods 2022 6 0 0 7D5O C-Src in complex with TAS-120 2020-09-27 2021-12-22 Qu, L.,Chen, X.,Wei, H.,Guo, M.,Dai, S.,Jiang, L.,Li, J.,Yue, S.,Chen, Z.,Chen, Y. Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors Commun Chem 2022 5 5 0 7DOQ 33450485 Lp major histidine acid phosphatase mutant D281A/5'-AMP 2020-12-16 2021-12-22 Guo, Y.,Zhou, D.,Zhang, H.,Zhang, N.N.,Qi, X.,Chen, X.,Chen, Q.,Li, J.,Ge, H.,Teng, Y.B. Structural insights into a new substrate binding mode of a histidine acid phosphatase from Legionella pneumophila. Biochem.Biophys.Res.Commun. 2021 540 90 94 7DQ9 33979121 Crystal structure of a type-A feruloyl esterase from gut Alistipes shahii 2020-12-22 2021-12-22 Wei, X.,Wang, Y.L.,Wen, B.T.,Liu, S.J.,Wang, L.,Sun, L.,Gu, T.Y.,Li, Z.,Bao, Y.,Fan, S.L.,Zhou, H.,Wang, F.,Xin, F. The alpha-Helical Cap Domain of a Novel Esterase from Gut Alistipes shahii Shaping the Substrate-Binding Pocket. J.Agric.Food Chem. 2021 69 6064 6072 7E0M 33809980 Crystal structure of phospholipase D 2021-01-28 2021-12-22 Wang, F.,Liu, S.,Mao, X.,Cui, R.,Yang, B.,Wang, Y. Crystal Structure of a Phospholipase D from the Plant-Associated Bacteria Serratia plymuthica Strain AS9 Reveals a Unique Arrangement of Catalytic Pocket. Int J Mol Sci 2021 22 0 0 7E17 Structure of dimeric uPAR 2021-02-01 2021-12-22 Yu, S.,Sui, Y.,Wang, J.,Li, Y.,Li, H.,Cao, Y.,Chen, L.,Jiang, L.,Yuan, C.,Huang, M. Crystal structure and cellular functions of uPAR dimer Nat Commun 2022 13 1665 0 7EA2 34389544 crystal structure of NAP1 FIR in complex with RB1CC1 Claw domain 2021-03-06 2021-12-22 Fu, T.,Zhang, M.,Zhou, Z.,Wu, P.,Peng, C.,Wang, Y.,Gong, X.,Li, Y.,Wang, Y.,Xu, X.,Li, M.,Shen, L.,Pan, L. Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52. Sci Adv 2021 7 0 0 7EA7 34389544 crystal structure of NAP1 LIR in complex with GABARAP 2021-03-06 2021-12-22 Fu, T.,Zhang, M.,Zhou, Z.,Wu, P.,Peng, C.,Wang, Y.,Gong, X.,Li, Y.,Wang, Y.,Xu, X.,Li, M.,Shen, L.,Pan, L. Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52. Sci Adv 2021 7 0 0 7EAA 34389544 crystal structure of NDP52 SKICH domain in complex with RB1CC1 coiled-coil domain 2021-03-06 2021-12-22 Fu, T.,Zhang, M.,Zhou, Z.,Wu, P.,Peng, C.,Wang, Y.,Gong, X.,Li, Y.,Wang, Y.,Xu, X.,Li, M.,Shen, L.,Pan, L. Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52. Sci Adv 2021 7 0 0 7EE4 35012347 Crystal structure of Neu5Ac bound PltC 2021-03-17 2021-12-22 Liu, X.,Chen, Z.,Jiao, X.,Jiang, X.,Qiu, J.,You, F.,Long, H.,Cao, H.,Fowler, C.C.,Gao, X. Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin. Mbio 2022 13 0 0 7FBB 35140398 De novo design protein D12 with MBP tag 2021-07-09 2021-12-22 Huang, B.,Xu, Y.,Hu, X.,Liu, Y.,Liao, S.,Zhang, J.,Huang, C.,Hong, J.,Chen, Q.,Liu, H. A backbone-centred energy function of neural networks for protein design. Nature 2022 602 523 528 7W8A 35071043 Babesia orientalis lactate dehydrogenase, BoLDH apo 2021-12-07 2021-12-22 Yu, L.,Liu, Q.,Luo, W.,Zhao, J.,Alzan, H.F.,He, L. The Structural Basis of Babesia orientalis Lactate Dehydrogenase. Front Cell Infect Microbiol 2021 11 790101 790101 7DR8 Crystal structure of MERS-CoV 3CL protease in spacegroup P212121 2020-12-26 2021-12-29 Zhang, Y.T.,Gao, H.X.,Zhou, H.,Zhong, F.L.,Hu, X.H.,Zhou, X.L.,Lin, C.,Wang, Q.S.,Li, J.,Zhang, J. Crystal structure of MERS-CoV 3CL protease in spacegroup P212121 To Be Published 0 0 0 0 7DR9 Crystal structure of MERS-CoV 3CL protease (C148A) in spacegroup P212121 2020-12-27 2021-12-29 Zhong, F.L.,Lin, C.,Zhang, J.,Li, J. Crystal structure of MERS-CoV 3CL protease (C148A) in spacegroup P212121 To Be Published 0 0 0 0 7DRA Crystal structure of MERS-CoV 3CL protease (C148A) in spacegroup P212121,pH 9.0 2020-12-27 2021-12-29 Zhang, Y.T.,Zhou, X.L.,Li, J.,Zhang, J. Crystal structure of MERS-CoV 3CL protease (C148A) in spacegroup P212121,pH 9.0 To Be Published 0 0 0 0 7F0H 34509703 Structural and functional characterization of bovine G1P[5] rotavirus VP8* protein 2021-06-04 2021-12-29 Dang, L.,Su, Y.,Qi, J.,Wu, Z.,Li, D.,Wang, M.,Zhang, Q.,Wang, H.,Bai, R.,Duan, Z.,Sun, X. Structural and functional characterization of bovine G1P[5] rotavirus VP8* protein. Virology 2021 563 116 125 7V6K 35308030 Crystal structure of Sortase A from Streptococcus pyogenes in complex with ML346 2021-08-20 2021-12-29 Guan, X.N.,Zhang, T.,Yang, T.,Dong, Z.,Yang, S.,Lan, L.,Gan, J.,Yang, C.G. Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella. Rsc Med Chem 2022 13 138 149 7V6P 34819355 Crystal structure of human sNASP TPR domain 2021-08-20 2021-12-29 Liu, C.P.,Jin, W.,Hu, J.,Wang, M.,Chen, J.,Li, G.,Xu, R.M. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev. 2021 35 1610 1624 7V6Q 34819355 Crystal structure of sNASP-ASF1A-H3.1-H4 complex 2021-08-20 2021-12-29 Liu, C.P.,Jin, W.,Hu, J.,Wang, M.,Chen, J.,Li, G.,Xu, R.M. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev. 2021 35 1610 1624 7WA8 33793945 Strigolactone receptors in Striga ShHTL7 2021-12-12 2022-01-05 Xie, D.,Smith, M.S.,Yao, R.,Wang, Y. Molecular basis for high ligand sensitivity and selectivity of strigolactone receptors in Striga. Plant Physiology 2021 0 1411 1428 7WA8 33793945 Strigolactone receptors in Striga ShHTL7 2021-12-12 2022-01-05 Xie, D.,Smith, M.S.,Yao, R.,Wang, Y. Molecular basis for high ligand sensitivity and selectivity of strigolactone receptors in Striga. Plant Physiology 2021 0 1411 1428 7DT0 Proline hydroxylase H11-N101I mutant 2021-01-04 2022-01-12 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 with AKG and L-proline To Be Published 0 0 0 0 7DT1 The structure of Lactobacillus fermentum 4,6-alpha-Glucanotransferase 2021-01-04 2022-01-12 Yang, W.,Sheng, L.,Chen, S.,Wang, L.,Su, L.,Wu, J. Characterization of a new 4,6-alpha-glucanotransferase from Limosilactobacillus fermentum NCC 3057 with ability of synthesizing low molecular mass isomalto-/maltopolysaccharide Food Biosci 2022 46 101514 0 7DV4 35925889 Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 2021-01-12 2022-01-12 Gan, X.,Shan, Q.,Li, H.,Janssens, R.,Shen, Y.,He, Y.,Chen, F.,van Haperen, R.,Drabek, D.,Li, J.,Zhang, Y.,Zhao, J.,Qin, B.,Jheng, M.J.,Chen, V.,Wang, J.,Rong, Y.,Grosveld, F. An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7DUP Apo structure of wild type Bt4394, a GH20 family sulfoglycosidase 2021-01-10 2022-01-19 Zhang, Z.,Dong, M.,Zallot, R.,Blackburn, G.M.,Wang, N.,Wang, C.,Chen, L.,Baumann, P.,Wu, Z.,Wang, Z.,Fan, H.,Roth, C.,Jin, Y.,He, Y. Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis 2023 13 824 836 7DUP Apo structure of wild type Bt4394, a GH20 family sulfoglycosidase 2021-01-10 2022-01-19 Zhang, Z.,Dong, M.,Zallot, R.,Blackburn, G.M.,Wang, N.,Wang, C.,Chen, L.,Baumann, P.,Wu, Z.,Wang, Z.,Fan, H.,Roth, C.,Jin, Y.,He, Y. Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis 2023 13 824 836 7DVA Structure of wild type Bt4394, a GH20 family sulfoglycosidase, in complex with 6S-GlcNAc 2021-01-13 2022-01-19 Zhang, Z.,Dong, M.,Zallot, R.,Blackburn, G.M.,Wang, N.,Wang, C.,Chen, L.,Baumann, P.,Wu, Z.,Wang, Z.,Fan, H.,Roth, C.,Jin, Y.,He, Y. Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis 2023 13 824 836 7DVA Structure of wild type Bt4394, a GH20 family sulfoglycosidase, in complex with 6S-GlcNAc 2021-01-13 2022-01-19 Zhang, Z.,Dong, M.,Zallot, R.,Blackburn, G.M.,Wang, N.,Wang, C.,Chen, L.,Baumann, P.,Wu, Z.,Wang, Z.,Fan, H.,Roth, C.,Jin, Y.,He, Y. Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis 2023 13 824 836 7VPH 35096974 Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 2021-10-17 2022-01-19 Li, T.,Wen, Y.,Guo, H.,Yang, T.,Yang, H.,Ji, X. Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export. Front Mol Biosci 2021 8 813248 813248 7DQX Crystal structure of xanthine dehydrogenase family protein 2020-12-24 2022-01-26 Lei, W. crystal structure of xanthine dehydrogenase family protein To Be Published 0 0 0 0 7DY7 35188766 Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation 2021-01-20 2022-01-26 Wang, T.,Cai, S.,Cheng, Y.,Zhang, W.,Wang, M.,Sun, H.,Guo, B.,Li, Z.,Xiao, Y.,Jiang, S. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J.Med.Chem. 2022 65 3879 3893 7EWU 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (WT) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7EWV 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (H34A mutant) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7EWW 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (N52A mutant) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7EWX 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (P78A mutant) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7EWY 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (D79A mutant) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7EWZ 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (D92A mutant) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7EX0 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (K108A mutant) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7EX1 35044209 Crystal structure of Ebinur Lake virus cap snatching endonuclease (Y109A mutant) 2021-05-26 2022-01-26 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Hu, Z.,Guo, Y.,Wang, M.,Zhou, Y.,Gong, P. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. J.Virol. 2022 96 0 0 7W7L 36779700 Structure of NF-kB p52 homodimer bound to 13-mer A/T-centric P-Selectin kB DNA fragment 2021-12-05 2022-01-26 Pan, W.,Meshcheryakov, V.A.,Li, T.,Wang, Y.,Ghosh, G.,Wang, V.Y. Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation. Elife 2023 12 0 0 7DKM 34971423 PHGDH covalently linked to oridonin 2020-11-25 2022-02-02 Tan, Y.,Zhou, X.,Gong, Y.,Gou, K.,Luo, Y.,Jia, D.,Dai, L.,Zhao, Y.,Sun, Q. Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors. Cell.Mol.Life Sci. 2021 79 27 27 7DZZ Trans-3/4-proline-hydroxylase H11-stateV 2021-01-26 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11-stateV To Be Published 0 0 0 0 7E00 Trans-proline-hydroxylase H11 with Succinic and L-proline in the fourth reaction state. 2021-01-26 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 with AKG and L-proline To Be Published 0 0 0 0 7E01 Trans-3/4-proline-hydroxylase H11 in the sixth reaction state 2021-01-26 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 with 3-Hydroxyl-proline To Be Published 0 0 0 0 7E04 Crystal structure of Bomgl, a monoacylglycerol lipase from marine Bacillus sp. 2021-01-27 2022-02-02 Wang, Y.H.,Wang, J.,Lan, D.M. Crystal structure of Bomgl, a monoacylglycerol lipase from marine Bacillus To Be Published 0 0 0 0 7E05 Trans-3/4-proline-hydroxylase H11 apo structure 2021-01-27 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 with AKG and L-proline To Be Published 0 0 0 0 7E06 Trans-3/4-proline-hydroxylase H11 with AKG 2021-01-27 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 with AKG and L-proline To Be Published 0 0 0 0 7E07 Trans-3/4-proline-hydroxylase H11 with AKG and L-proline 2021-01-27 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 with AKG and L-proline To Be Published 0 0 0 0 7E08 Trans-3/4-proline-hydroxylase H11 with 4-Hydroxyl-proline 2021-01-27 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 4-Hydroxyl-proline To Be Published 0 0 0 0 7E09 Trans-3/4-proline-hydroxylase H11 with 3-hydroxyl-proline 2021-01-27 2022-02-02 Gong, W.G.,Yang, L.Y. Trans-3/4-proline-hydroxylase H11 with AKG and L-proline To Be Published 0 0 0 0 7E0B 35022217 The crystal structure of sorting nexin 27 and PBM complex 2021-01-27 2022-02-02 Yang, B.,Jia, Y.,Meng, Y.,Xue, Y.,Liu, K.,Li, Y.,Liu, S.,Li, X.,Cui, K.,Shang, L.,Cheng, T.,Zhang, Z.,Hou, Y.,Yang, X.,Yan, H.,Duan, L.,Tong, Z.,Wu, C.,Liu, Z.,Gao, S.,Zhuo, S.,Huang, W.,Gao, G.F.,Qi, J.,Shang, G. SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7E13 Caprylic acid targets a serine hydroxymethyltransferase to kill horseweed 2021-01-29 2022-02-02 Li, Z.R.,Bai, L.Y. serine hydroxymethyltransferase To Be Published 0 0 0 0 7E1L 35568198 Crystal structure of apo form PhlH 2021-02-01 2022-02-02 Zhang, N.,Wu, J.,Zhang, S.,Yuan, M.,Xu, H.,Li, J.,Zhang, P.,Wang, M.,Kempher, M.L.,Tao, X.,Zhang, L.Q.,Ge, H.,He, Y.X. Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules. J.Biol.Chem. 2022 298 102027 102027 7E1N 35568198 Crystal structure of PhlH in complex with 2,4-diacetylphloroglucinol 2021-02-02 2022-02-02 Zhang, N.,Wu, J.,Zhang, S.,Yuan, M.,Xu, H.,Li, J.,Zhang, P.,Wang, M.,Kempher, M.L.,Tao, X.,Zhang, L.Q.,Ge, H.,He, Y.X. Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules. J.Biol.Chem. 2022 298 102027 102027 7VJS 35120926 Human AlkB homolog ALKBH6 in complex with Tris and Ni 2021-09-28 2022-02-02 Ma, L.,Lu, H.,Tian, Z.,Yang, M.,Ma, J.,Shang, G.,Liu, Y.,Xie, M.,Wang, G.,Wu, W.,Zhang, Z.,Dai, S.,Chen, Z. Structural insights into the interactions and epigenetic functions of human nucleic acid repair protein ALKBH6. J.Biol.Chem. 2022 298 101671 101671 7VJV 35120926 Human AlkB homolog ALKBH6 in complex with alpha-katoglutarate and Mn 2021-09-29 2022-02-02 Ma, L.,Lu, H.,Tian, Z.,Yang, M.,Ma, J.,Shang, G.,Liu, Y.,Xie, M.,Wang, G.,Wu, W.,Zhang, Z.,Dai, S.,Chen, Z. Structural insights into the interactions and epigenetic functions of human nucleic acid repair protein ALKBH6. J.Biol.Chem. 2022 298 101671 101671 7VW8 35163109 Helicoverpa armigera pheromone-binding protein PBP1 at pH 7.5 2021-11-09 2022-02-02 Zheng, J.,Yang, M.,Dong, K.,Zhang, J.,Wang, H.,Xie, M.,Wu, W.,Zhang, Y.J.,Chen, Z. Structural Insights into the Ligand-Binding and -Releasing Mechanism of Helicoverpa armigera Pheromone-Binding Protein PBP1. Int J Mol Sci 2022 23 0 0 7VW9 35163109 Helicoverpa armigera pheromone-binding protein PBP1 at pH 5.5 2021-11-10 2022-02-02 Zheng, J.,Yang, M.,Dong, K.,Zhang, J.,Wang, H.,Xie, M.,Wu, W.,Zhang, Y.J.,Chen, Z. Structural Insights into the Ligand-Binding and -Releasing Mechanism of Helicoverpa armigera Pheromone-Binding Protein PBP1. Int J Mol Sci 2022 23 0 0 7VWA 35163109 Helicoverpa armigera pheromone-binding protein PBP1 with Z-9-hexadecenal 2021-11-10 2022-02-02 Zheng, J.,Yang, M.,Dong, K.,Zhang, J.,Wang, H.,Xie, M.,Wu, W.,Zhang, Y.J.,Chen, Z. Structural Insights into the Ligand-Binding and -Releasing Mechanism of Helicoverpa armigera Pheromone-Binding Protein PBP1. Int J Mol Sci 2022 23 0 0 7VYW 35074427 Crystal structure of the chromodomain of Arabidopsis LHP1 in complex with methylated histone H3K9 peptide 2021-11-15 2022-02-02 Liu, Y.,Yang, X.,Zhou, M.,Yang, Y.,Li, F.,Yan, X.,Zhang, M.,Wei, Z.,Qin, S.,Min, J. Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain. J.Biol.Chem. 2022 298 101623 101623 7E0V GDPD from Pyrococcus furiosus DSM 3638 2021-01-28 2022-02-09 Wang, Y.H.,Wang, J.,Wang, F.H. Crystal structure of Bomgl, a monoacylglycerol lipase from marine Bacillus To Be Published 0 0 0 0 7E1B 36647726 Crystal structure of VbrR-DNA complex 2021-02-01 2022-02-09 Hong, S.,Guo, J.,Zhang, X.,Zhou, X.,Zhang, P.,Yu, F. Structural basis of phosphorylation-induced activation of the response regulator VbrR. Acta Biochim.Biophys.Sin. 2023 0 0 0 7E29 35188579 Crystal Structure of Saccharomyces cerevisiae Ioc4 PWWP domain fused with MBP 2021-02-05 2022-02-09 Li, J.,Bergmann, L.,Rafael de Almeida, A.,Webb, K.M.,Gogol, M.M.,Voigt, P.,Liu, Y.,Liang, H.,Smolle, M.M. H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function. Nucleic Acids Res. 2022 50 2549 2565 7E2A GDPD mutant from Pyrococcus furiosus DSM 3638 2021-02-05 2022-02-09 Wang, Y.H.,Wang, J.,Wang, F.H. Crystal structure of glycerophoshphodiester phospodiesterase D60A mutant from Pyrococcus furiosus DSM To Be Published 0 0 0 0 7E2B GDPD mutant complex from Pyrococcus furiosus DSM 3638 2021-02-05 2022-02-09 Wang, Y.H.,Wang, J.,Wang, F.H. Observation of the GPC production during hydrolysis of LPC by GDPD D60A from Pyrococcus furiosus DSM 3638 To Be Published 0 0 0 0 7E4K WNV envelope protein 2021-02-13 2022-02-16 Xiao, H.,Qi, J. WNV envelope protein To Be Published 0 0 0 0 7ELT 34908399 Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Trp-AMP 2021-04-12 2022-02-16 Yang, Y.,Xu, Y.,Yue, Y.,Wang, H.,Cui, Y.,Pan, M.,Zhang, X.,Zhang, L.,Li, H.,Xu, M.,Tang, Y.,Chen, S. Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol. 2022 17 39 53 7ENS 34908399 Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Indolmycin and ATP 2021-04-19 2022-02-16 Yang, Y.,Xu, Y.,Yue, Y.,Wang, H.,Cui, Y.,Pan, M.,Zhang, X.,Zhang, L.,Li, H.,Xu, M.,Tang, Y.,Chen, S. Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol. 2022 17 39 53 7EX2 35266805 Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with L-742,001 (methyl ester form) 2021-05-26 2022-02-16 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol. 2022 96 0 0 7EX3 35266805 Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 3 2021-05-26 2022-02-16 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol. 2022 96 0 0 7EX4 35266805 Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 5 2021-05-26 2022-02-16 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol. 2022 96 0 0 7EX6 35266805 Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 11 2021-05-26 2022-02-16 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol. 2022 96 0 0 7EX7 35266805 Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 16 2021-05-26 2022-02-16 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol. 2022 96 0 0 7EX8 35266805 Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 27 2021-05-26 2022-02-16 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol. 2022 96 0 0 7EX9 35266805 Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 28 2021-05-26 2022-02-16 Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol. 2022 96 0 0 7F6W 35133502 Crystal structure of Saccharomyces cerevisiae lysyl-tRNA Synthetase 2021-06-26 2022-02-16 Wu, S.,Zheng, L.,Hei, Z.,Zhou, J.B.,Li, G.,Li, P.,Wang, J.,Ali, H.,Zhou, X.L.,Wang, J.,Fang, P. Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex. Cell.Mol.Life Sci. 2022 79 128 128 7FH6 Friedel-Crafts alkylation enzyme CylK 2021-07-29 2022-02-16 Wang, H.Q.,Mou, S.B.,Xiao, W.,Zhou, H.,Hou, X.D.,Wang, S.J.,Wang, Q.,Gao, J.,Wei, Z.,Liu, L.,Xiang, Z. Structural Basis for the Friedel-Crafts Alkylation in Cylindrocyclophane Biosynthesis ACS Catal. 2022 12 2108 2117 7FH7 Friedel-Crafts alkylation enzyme CylK mutant Y37F 2021-07-29 2022-02-16 Wang, H.Q.,Mou, S.B.,Xiao, W.,Zhou, H.,Hou, X.D.,Wang, S.J.,Wang, Q.,Gao, J.,Wei, Z.,Liu, L.,Xiang, Z. Structural Basis for the Friedel-Crafts Alkylation in Cylindrocyclophane Biosynthesis ACS Catal. 2022 12 2108 2117 7FH8 Friedel-Crafts alkylation enzyme CylK mutant H391A 2021-07-29 2022-02-16 Wang, H.Q.,Mou, S.B.,Xiao, W.,Zhou, H.,Hou, X.D.,Wang, S.J.,Wang, Q.,Gao, J.,Wei, Z.,Liu, L.,Xiang, Z. Structural Basis for the Friedel-Crafts Alkylation in Cylindrocyclophane Biosynthesis ACS Catal. 2022 12 2108 2117 7V9F 35143257 Selenomethionine mutant (L740Sem) of BEN4 domain of protein Bend3 with DNA 2021-08-25 2022-02-16 Zhang, J.,Zhang, Y.,You, Q.,Huang, C.,Zhang, T.,Wang, M.,Zhang, T.,Yang, X.,Xiong, J.,Li, Y.,Liu, C.P.,Zhang, Z.,Xu, R.M.,Zhu, B. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science 2022 375 1053 1058 7V9G 35143257 Native BEN4 domain of protein Bend3 with DNA 2021-08-25 2022-02-16 Zhang, J.,Zhang, Y.,You, Q.,Huang, C.,Zhang, T.,Wang, M.,Zhang, T.,Yang, X.,Xiong, J.,Li, Y.,Liu, C.P.,Zhang, Z.,Xu, R.M.,Zhu, B. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science 2022 375 1053 1058 7V9H 35143257 The BEN3 domain of protein Bend3 2021-08-25 2022-02-16 Zhang, J.,Zhang, Y.,You, Q.,Huang, C.,Zhang, T.,Wang, M.,Zhang, T.,Yang, X.,Xiong, J.,Li, Y.,Liu, C.P.,Zhang, Z.,Xu, R.M.,Zhu, B. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science 2022 375 1053 1058 7E6K Viral protease 2021-02-22 2022-02-23 Zhao, Y.,Zhang, Q.,Yang, H.T.,Rao, Z.H. Viral protease To be published 0 0 0 0 7ETV 34401048 The FK1 domain of FKBP51 in complex with peptide-inhibitor hit DFPFV 2021-05-14 2022-02-23 Han, J.T.,Zhu, Y.,Pan, D.B.,Xue, H.X.,Wang, S.,Peng, Y.,Liu, H.,He, Y.X.,Yao, X. Discovery of pentapeptide-inhibitor hits targeting FKBP51 by combining computational modeling and X-ray crystallography. Comput Struct Biotechnol J 2021 19 4079 4091 7F7G 34458841 a linear Peptide Inhibitors in complex with GK domain 2021-06-29 2022-02-23 Unarta, I.C.,Xu, J.,Shang, Y.,Cheung, C.H.P.,Zhu, R.,Chen, X.,Cao, S.,Cheung, P.P.,Bierer, D.,Zhang, M.,Huang, X.,Li, X. Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. Rsc Chem Biol 2021 2 1274 1284 7W8N 35069500 Microbial Hormone-sensitive lipase E53 wild type 2021-12-08 2022-02-23 Ding, Y.,Nie, L.,Yang, X.C.,Li, Y.,Huo, Y.Y.,Li, Z.,Gao, Y.,Cui, H.L.,Li, J.,Xu, X.W. Mechanism and Structural Insights Into a Novel Esterase, E53, Isolated From Erythrobacter longus . Front Microbiol 2021 12 798194 798194 7E6O Crystal structure of polyol dehydrogenase from Paracoccus denitrificans 2021-02-22 2022-03-02 Sha, F.,Zheng, Y.C.,Gao, J. Crystal structure of polyol dehydrogenase from Paracoccus denitrificans To Be Published 0 0 0 0 7E8K 35484139 Crystal structure of Proteinaceous RNase P (PRORP) from Planctomycetes bacterium GWF2_40_8 2021-03-02 2022-03-02 Li, Y.,Su, S.,Gao, Y.,Lu, G.,Liu, H.,Chen, X.,Shao, Z.,Zhang, Y.,Shao, Q.,Zhao, X.,Yang, J.,Cao, C.,Lin, J.,Ma, J.,Gan, J. Crystal structures and insights into precursor tRNA 5'-end processing by prokaryotic minimal protein-only RNase P. Nat Commun 2022 13 2290 2290 7E8O 35484139 Crystal structure of proteinaceous RNase P(PRORP) from Planctomycetes bacterium GWF2_40_8 complexed with Escherichia coli histidine pre-tRNA 2021-03-02 2022-03-02 Li, Y.,Su, S.,Gao, Y.,Lu, G.,Liu, H.,Chen, X.,Shao, Z.,Zhang, Y.,Shao, Q.,Zhao, X.,Yang, J.,Cao, C.,Lin, J.,Ma, J.,Gan, J. Crystal structures and insights into precursor tRNA 5'-end processing by prokaryotic minimal protein-only RNase P. Nat Commun 2022 13 2290 2290 7VHR 35090095 Apostichopus japonicus ferritin 2021-09-22 2022-03-02 Wu, Y.,Ming, T.,Huo, C.,Qiu, X.,Su, C.,Lu, C.,Zhou, J.,Li, Y.,Su, X. Crystallographic characterization of a marine invertebrate ferritin from the sea cucumber Apostichopus japonicus. Febs Open Bio 2022 12 664 674 7VOH 35308395 The a-glucosidase QsGH13 from Qipengyuania seohaensis 2021-10-13 2022-03-02 Zhai, X.,Wu, K.,Ji, R.,Zhao, Y.,Lu, J.,Yu, Z.,Xu, X.,Huang, J. Structure and Function Insight of the alpha-Glucosidase QsGH13 From Qipengyuania seohaensis sp. SW-135. Front Microbiol 2022 13 849585 849585 7WF5 35151199 c-Src in complex with ponatinib 2021-12-26 2022-03-02 Guo, M.,Duan, Y.,Dai, S.,Li, J.,Chen, X.,Qu, L.,Chen, Z.,Wei, H.,Jiang, L.,Chen, Y. Structural study of ponatinib in inhibiting SRC kinase. Biochem.Biophys.Res.Commun. 2022 598 15 19 7CQR Complex structure of HPPD with Y16550 2020-08-11 2022-03-16 Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F. Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules Adv Agrochem 2022 0 0 0 7CQS Complex structure of HPPD with Topramezone 2020-08-11 2022-03-16 Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F. Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules Adv Agrochem 2022 0 0 0 7E0N Crystal structure of Monoacylglycerol Lipase chimera 2021-01-28 2022-03-16 Lan, D.M.,Wang, Y.H. Crystal structure of Monoacylglycerol Lipase chimera To Be Published 0 0 0 0 7FCO ChlB4 Halogenase 2021-07-15 2022-03-16 Saeed, A.U.,Zheng, J. Crystal insight of FAD-dependent bifunctional halogenase ChlB4 in the biosynthesis of Chlorothricin To Be Published 0 0 0 0 7VUE 35091108 Structural insight of the molecular mechanism of cilofexor bound to FXR 2021-11-02 2022-03-16 Jiang, L.,Liu, X.,Wei, H.,Dai, S.,Qu, L.,Chen, X.,Guo, M.,Chen, Y. Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor. Biochem.Biophys.Res.Commun. 2022 595 1 6 7WAA 35263219 Crystal structure of MCR-1-S treated by AgNO3 2021-12-13 2022-03-16 Zhang, Q.,Wang, R.,Wang, M.,Liu, C.,Koohi-Moghadam, M.,Wang, H.,Ho, P.L.,Li, H.,Sun, H. Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7E3M RORgamma LBD complexed with Panaxatriol and SRC2.2 2021-02-09 2022-03-23 Liu, Z.H.,Huang, J.,Wu, Z.R.,Tang, Y.,Lu, W.Q. Structure of human RORgammat LBD with SRC2.2 at 2.80 Angstroms resolution To Be Published 0 0 0 0 7EEE 34329700 Complex structure of glycoside hydrolase family 12 beta-1,3-1,4-glucanase with gentiobiose 2021-03-18 2022-03-23 Ma, J.,Li, Y.,Han, S.,Jiang, Z.,Yan, Q.,Yang, S. Structural and biochemical insights into the substrate-binding mechanism of a glycoside hydrolase family 12 beta-1,3-1,4-glucanase from Chaetomium sp. J.Struct.Biol. 2021 213 107774 107774 7EEJ 34329700 Complex structure of glycoside hydrolase family 12 beta-1,3-1,4-glucanase with cellobiose 2021-03-18 2022-03-23 Ma, J.,Li, Y.,Han, S.,Jiang, Z.,Yan, Q.,Yang, S. Structural and biochemical insights into the substrate-binding mechanism of a glycoside hydrolase family 12 beta-1,3-1,4-glucanase from Chaetomium sp. J.Struct.Biol. 2021 213 107774 107774 7EEK Structure of Human serum albumin-Au compound complex 2021-03-18 2022-03-23 Yang, F.,Zhang, J.Z. Structure of Human serum albumin-Au compound complex To Be Published 0 0 0 0 7ESO 34856215 Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY 2021-05-11 2022-03-23 Zhang, C.,Li, Y.,Samad, A.,Zheng, P.,Ji, Z.,Chen, F.,Zhang, H.,Jin, T. Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY. Int.J.Biol.Macromol. 2022 194 42 49 7ESP 34856215 Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY 2021-05-11 2022-03-23 Zhang, C.,Li, Y.,Samad, A.,Zheng, P.,Ji, Z.,Chen, F.,Zhang, H.,Jin, T. Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY. Int.J.Biol.Macromol. 2022 194 42 49 7ESQ 34856215 Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY 2021-05-11 2022-03-23 Zhang, C.,Li, Y.,Samad, A.,Zheng, P.,Ji, Z.,Chen, F.,Zhang, H.,Jin, T. Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY. Int.J.Biol.Macromol. 2022 194 42 49 7ESV 34856215 Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY 2021-05-11 2022-03-23 Zhang, C.,Li, Y.,Samad, A.,Zheng, P.,Ji, Z.,Chen, F.,Zhang, H.,Jin, T. Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY. Int.J.Biol.Macromol. 2022 194 42 49 7ETR 34946107 Crystal structure of SO_1444-SO_1445 complex from Shewanella oneidensis 2021-05-13 2022-03-23 Zhou, J.,Du, X.J.,Liu, Y.,Gao, Z.Q.,Geng, Z.,Dong, Y.H.,Zhang, H. Insights into the Neutralization and DNA Binding of Toxin-Antitoxin System ParE SO-CopA SO by Structure-Function Studies. Microorganisms 2021 9 0 0 7NRJ Crystal Structure of a Class D carbapenemase complexed with iodide 2021-03-04 2022-03-23 Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y. An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci. 2023 0 0 0 7NRJ Crystal Structure of a Class D carbapenemase complexed with iodide 2021-03-04 2022-03-23 Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y. An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci. 2023 0 0 0 7SCP The crystal structure of ScoE in complex with intermediate 2021-09-28 2022-03-23 Chen, T.Y.,Zheng, Z.,Zhang, X.,Chen, J.,Cha, L.,Tang, Y.,Guo, Y.,Zhou, J.,Wang, B.,Liu, H.W.,Chang, W.C. Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N-C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis Acs Catalysis 2022 12 2270 2279 7SCP The crystal structure of ScoE in complex with intermediate 2021-09-28 2022-03-23 Chen, T.Y.,Zheng, Z.,Zhang, X.,Chen, J.,Cha, L.,Tang, Y.,Guo, Y.,Zhou, J.,Wang, B.,Liu, H.W.,Chang, W.C. Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N-C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis Acs Catalysis 2022 12 2270 2279 7VXG 35310939 Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453 2021-11-12 2022-03-23 Wang, M.,Li, T.,Ouyang, Z.,Tang, K.,Zhu, Y.,Song, C.,Sun, H.,Yu, B.,Ji, X.,Sun, Y. SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis. Iscience 2022 25 104009 104009 7EGY Recombinant head-to-tail dimeric E2 protein 2021-03-27 2022-03-30 Ru, Q.X. Recombinant head-to-tail dimeric E2 protein To Be Published 0 0 0 0 7EHW BRD4-BD1 in complex with LT-642-602 2021-03-30 2022-03-30 Zheng, W.,Kong, B.,Tang, W.,Zhu, J.,Chen, Y. BRD4-BD1 in complex with LT-642-602 To Be Published 0 0 0 0 7EHY BRD4-BD1 in complex with LT-448-138 2021-03-30 2022-03-30 Zheng, W.,Kong, B.,Tang, W.,Zhu, J.,Chen, Y. BRD4-BD1 in complex with LT-642-602 To Be Published 0 0 0 0 7V29 36697897 Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor 2021-08-07 2022-03-30 Chen, X.,Li, H.,Lin, Q.,Dai, S.,Yue, S.,Qu, L.,Li, M.,Guo, M.,Wei, H.,Li, J.,Jiang, L.,Xu, G.,Chen, Y. Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem 2022 5 36 36 7V8E 35294289 Crystal structure of IpaH1.4 LRR domain bound to HOIL-1L UBL domain. 2021-08-22 2022-03-30 Liu, J.,Wang, Y.,Wang, D.,Wang, Y.,Xu, X.,Zhang, Y.,Li, Y.,Zhang, M.,Gong, X.,Tang, Y.,Shen, L.,Li, M.,Pan, L. Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7V8G 35294289 Crystal structure of HOIP RING1 domain bound to IpaH1.4 LRR domain 2021-08-23 2022-03-30 Liu, J.,Wang, Y.,Wang, D.,Wang, Y.,Xu, X.,Zhang, Y.,Li, Y.,Zhang, M.,Gong, X.,Tang, Y.,Shen, L.,Li, M.,Pan, L. Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7DN1 35801308 Hetero-oligomers of SCR-SCR2 crystal structure with NADPH 2020-12-08 2022-04-06 Li, Y.,Zhang, R.,Wang, C.,Forouhar, F.,Clarke, O.B.,Vorobiev, S.,Singh, S.,Montelione, G.T.,Szyperski, T.,Xu, Y.,Hunt, J.F. Oligomeric interactions maintain active-site structure in a noncooperative enzyme family. Embo J. 2022 41 0 0 7DN1 35801308 Hetero-oligomers of SCR-SCR2 crystal structure with NADPH 2020-12-08 2022-04-06 Li, Y.,Zhang, R.,Wang, C.,Forouhar, F.,Clarke, O.B.,Vorobiev, S.,Singh, S.,Montelione, G.T.,Szyperski, T.,Xu, Y.,Hunt, J.F. Oligomeric interactions maintain active-site structure in a noncooperative enzyme family. Embo J. 2022 41 0 0 7EGR Co-crystal structure of Ac-AChBPP in complex with RgIA 2021-03-26 2022-04-06 Wang, X.Q.,Pan, S.,Fan, Y.X.,Xue, Y.,Zhu, X.P.,Luo, S.L. Co-crystal structure of Ac-AChBPP in complex with RgIA To Be Published 0 0 0 0 7EGS 35355008 The crystal structure of lobe domain of E. coli RNA polymerase complexed with the C-terminal domain of UvrD 2021-03-26 2022-04-06 Bharati, B.K.,Gowder, M.,Zheng, F.,Alzoubi, K.,Svetlov, V.,Kamarthapu, V.,Weaver, J.W.,Epshtein, V.,Vasilyev, N.,Shen, L.,Zhang, Y.,Nudler, E. Crucial role and mechanism of transcription-coupled DNA repair in bacteria. Nature 2022 604 152 159 7EIG BRD4-BD1 in complex with LT-730-903 2021-03-31 2022-04-06 Zheng, W.,Kong, B.,Tang, W.,Zhu, J.,Chen, Y. BRD4-BD1 in complex with LT-730-903 To Be Published 0 0 0 0 7EIK RD4-BD1 in complex with LT-872-297 2021-03-31 2022-04-06 Zheng, W.,Kong, B.,Tang, W.,Zhu, J.,Chen, Y. RD4-BD1 in complex with LT-872-297 To Be Published 0 0 0 0 7EIL BRD4-BD1 in complex with LT-909-110 2021-03-31 2022-04-06 Kong, B.,Zhu, Z.,Li, H.,Hong, Q.,Wang, C.,Ma, Y.,Zheng, W.,Jiang, F.,Zhang, Z.,Ran, T.,Bian, Y.,Yang, N.,Lu, T.,Zhu, J.,Tang, W.,Chen, Y. Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy Eur.J.Med.Chem. 2022 227 113953 0 7EJG Crystal structure of PBP domain of RMCA 2021-04-02 2022-04-06 Gu, L.,Li, N. Crystal structure of PBP domain of RMCA To Be Published 0 0 0 0 7FIU 35338130 Crystal structure of the DUB domain of Wolbachia cytoplasmic incompatibility factor CidB from wMel 2021-08-01 2022-04-06 Wang, H.,Xiao, Y.,Chen, X.,Zhang, M.,Sun, G.,Wang, F.,Wang, L.,Zhang, H.,Zhang, X.,Yang, X.,Li, W.,Wei, Y.,Yao, D.,Zhang, B.,Li, J.,Cui, W.,Wang, F.,Chen, C.,Shen, W.,Su, D.,Bai, F.,Huang, J.,Ye, S.,Zhang, L.,Ji, X.,Wang, W.,Wang, Z.,Hochstrasser, M.,Yang, H. Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Nat Commun 2022 13 1608 1608 7VLO 35389231 Crystal structure of SARS coronavirus main protease in complex with PF07321332 2021-10-05 2022-04-06 Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,Yang, Y.,Zhang, Y.,Yu, B.,Fan, X.,McCormick, P.J.,Fu, R.,Fu, Y.,Jiang, H.,Zhang, J. Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. J.Virol. 2022 96 0 0 7VLP 35389231 Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P1211 2021-10-05 2022-04-06 Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,Yang, Y.,Zhang, Y.,Yu, B.,Fan, X.,McCormick, P.J.,Fu, R.,Fu, Y.,Jiang, H.,Zhang, J. Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. J.Virol. 2022 96 0 0 7VLQ 35389231 Crystal structure of SARS-Cov-2 main protease in complex with PF07321332 in spacegroup P212121 2021-10-05 2022-04-06 Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,Yang, Y.,Zhang, Y.,Yu, B.,Fan, X.,McCormick, P.J.,Fu, R.,Fu, Y.,Jiang, H.,Zhang, J. Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. J.Virol. 2022 96 0 0 7W3S The complex structure of Larg1-ADPr from Legionella pneumophila 2021-11-26 2022-04-06 Fu, J.,Li, P.,Guan, H.,Huang, D.,Song, L.,Ouyang, S.,Luo, Z.Q. Legionella pneumophila temporally regulates the activity of ADP/ATP translocases by reversible ADP-ribosylation. mLife 2022 0 0 0 7WNN 35322515 Crystal structure of Imine Reductase from Actinoalloteichus hymeniacidonis in complex with NADPH 2022-01-19 2022-04-06 Zhang, J.,Liao, D.,Chen, R.,Zhu, F.,Ma, Y.,Gao, L.,Qu, G.,Cui, C.,Sun, Z.,Lei, X.,Gao, S.S. Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering. Angew.Chem.Int.Ed.Engl. 2022 61 0 0 7CJ1 The crystal structure of FXIa serine protease domain in complex with benzamidine 2020-07-09 2022-04-13 Jiang, L.,Huang, M. The crystal structure of FXIa serine protease domain in complex with benzamidine. To Be Published 0 0 0 0 7EJB Crystal structure of juvenile hormone acid methyltransferase JHAMT mutant Q15E 2021-04-01 2022-04-13 Guo, P.C.,Zhang, Y.S.,Zhang, l.,Xu, H.Y.,Xia, Q.Y. Structural insights into catalytic mechanism of juvenile hormone acid methyltransferase JHAMT To Be Published 0 0 0 0 7EJY 34480123 Complex Structure of antibody BD-503 and RBD of COVID-19 2021-04-03 2022-04-13 Xu, H.,Wang, B.,Zhao, T.N.,Liang, Z.T.,Peng, T.B.,Song, X.H.,Wu, J.J.,Wang, Y.C.,Su, X.D. Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants. Cell Res. 2021 31 1126 1129 7EJZ 34480123 Complex Structure of antibody BD-503 and RBD-S477N of COVID-19 2021-04-03 2022-04-13 Xu, H.,Wang, B.,Zhao, T.N.,Liang, Z.T.,Peng, T.B.,Song, X.H.,Wu, J.J.,Wang, Y.C.,Su, X.D. Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants. Cell Res. 2021 31 1126 1129 7EK0 34480123 Complex Structure of antibody BD-503 and RBD-N501Y of COVID-19 2021-04-03 2022-04-13 Xu, H.,Wang, B.,Zhao, T.N.,Liang, Z.T.,Peng, T.B.,Song, X.H.,Wu, J.J.,Wang, Y.C.,Su, X.D. Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants. Cell Res. 2021 31 1126 1129 7EKU Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W958A) 2021-04-06 2022-04-13 Shen, M.,Xiang, S. Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W958A) To Be Published 0 0 0 0 7QK4 35352560 EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683) 2021-12-17 2022-04-13 Huang, Y.,Sendzik, M.,Zhang, J.,Gao, Z.,Sun, Y.,Wang, L.,Gu, J.,Zhao, K.,Yu, Z.,Zhang, L.,Zhang, Q.,Blanz, J.,Chen, Z.,Dubost, V.,Fang, D.,Feng, L.,Fu, X.,Kiffe, M.,Li, L.,Luo, F.,Luo, X.,Mi, Y.,Mistry, P.,Pearson, D.,Piaia, A.,Scheufler, C.,Terranova, R.,Weiss, A.,Zeng, J.,Zhang, H.,Zhang, J.,Zhao, M.,Dillon, M.P.,Jeay, S.,Qi, W.,Moggs, J.,Pissot-Soldermann, C.,Li, E.,Atadja, P.,Lingel, A.,Oyang, C. Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem. 2022 65 5317 5333 7VNI 36266304 AHR-ARNT PAS-B heterodimer 2021-10-11 2022-04-13 Dai, S.,Qu, L.,Li, J.,Zhang, Y.,Jiang, L.,Wei, H.,Guo, M.,Chen, X.,Chen, Y. Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun 2022 13 6234 6234 7ENI Crystal structure of cas and anti-cas protein complex 2021-04-17 2022-04-20 Wang, Y.,Li, X. Crystal structure of cas and anti-cas protein complex To Be Published 0 0 0 0 7ENM Selenomethionine anti-Cas protein 2021-04-18 2022-04-20 Wang, Y.,Li, X. Selenomethionine anti-Cas protein To Be Published 0 0 0 0 7O5N Crystal Structure of a Class D carbapenemase complexed with Avibactam 2021-04-09 2022-04-20 Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y. An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci. 2023 0 0 0 7O5N Crystal Structure of a Class D carbapenemase complexed with Avibactam 2021-04-09 2022-04-20 Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y. An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci. 2023 0 0 0 7O5Q Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Oxacillin 2021-04-09 2022-04-20 Zhou, Q.,He, Y.,Jin, Y. Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Oxacillin To Be Published 0 0 0 0 7O5Q Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Oxacillin 2021-04-09 2022-04-20 Zhou, Q.,He, Y.,Jin, Y. Crystal Structure of a Class D Carbapenemase Complexed with Hydrolyzed Oxacillin To Be Published 0 0 0 0 7VVW 35618717 MmtN-SAM complex 2021-11-09 2022-04-20 Peng, M.,Li, C.Y.,Chen, X.L.,Williams, B.T.,Li, K.,Gao, Y.N.,Wang, P.,Wang, N.,Gao, C.,Zhang, S.,Schoelmerich, M.C.,Banfield, J.F.,Miller, J.B.,Le Brun, N.E.,Todd, J.D.,Zhang, Y.Z. Insights into methionine S-methylation in diverse organisms. Nat Commun 2022 13 2947 2947 7VVX 35618717 MmtN-SAH-Met complex 2021-11-09 2022-04-20 Peng, M.,Li, C.Y.,Chen, X.L.,Williams, B.T.,Li, K.,Gao, Y.N.,Wang, P.,Wang, N.,Gao, C.,Zhang, S.,Schoelmerich, M.C.,Banfield, J.F.,Miller, J.B.,Le Brun, N.E.,Todd, J.D.,Zhang, Y.Z. Insights into methionine S-methylation in diverse organisms. Nat Commun 2022 13 2947 2947 7CTX Crystal structure of Arabidopsis thaliana SOBIR1 kinase domain(residues 388-401 deleted) in complex with AMP-PNP and magnesium 2020-08-20 2022-04-27 Wei, X.,Wang, Y.L.,Gu, T.Y.,Xin, F.J. Crystal structure of Arabidopsis thaliana SOBIR1 kinase domain(residues 388-401 deleted) in complex with AMP-PNP and magnesium To Be Published 0 0 0 0 7E0Z 35297759 Crystal structure of PKAc-PLN complex 2021-01-28 2022-04-27 Qin, J.,Zhang, J.,Lin, L.,Haji-Ghassemi, O.,Lin, Z.,Woycechowsky, K.J.,Van Petegem, F.,Zhang, Y.,Yuchi, Z. Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife 2022 11 0 0 7E11 35297759 Crystal structure of PKAc-PLN R9C complex 2021-01-28 2022-04-27 Qin, J.,Zhang, J.,Lin, L.,Haji-Ghassemi, O.,Lin, Z.,Woycechowsky, K.J.,Van Petegem, F.,Zhang, Y.,Yuchi, Z. Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife 2022 11 0 0 7E12 35297759 Crystal structure of PKAc-A11E complex 2021-01-28 2022-04-27 Qin, J.,Zhang, J.,Lin, L.,Haji-Ghassemi, O.,Lin, Z.,Woycechowsky, K.J.,Van Petegem, F.,Zhang, Y.,Yuchi, Z. Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. Elife 2022 11 0 0 7EOA HR-PETase from Bacterium HR29 2021-04-21 2022-04-27 Wang, Y.H.,Wang, J.,Lan, D.M. Crystal structure of Bomgl, a monoacylglycerol lipase from marine Bacillus To Be Published 0 0 0 0 7F3B 34802838 cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor. 2021-06-16 2022-04-27 Li, Y.,Ouyang, Y.,Wu, H.,Wang, P.,Huang, Y.,Li, X.,Chen, H.,Sun, Y.,Hu, X.,Wang, X.,Li, G.,Lu, Y.,Li, C.,Lu, X.,Pang, J.,Nie, T.,Sang, X.,Dong, L.,Dong, W.,Jiang, J.,Paterson, I.C.,Yang, X.,Hong, W.,Wang, H.,You, X. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur.J.Med.Chem. 2022 228 113979 113979 7X2R Crystal structure of the E. coli transcription termination factor Rho 2022-02-26 2022-04-27 Wang, B.,Zheng, J. E. coli transcription termination factor Rho To Be Published 0 0 0 0 7ENQ 35459935 Crystal structure of human NAMPT in complex with compound NAT 2021-04-19 2022-05-04 Yao, H.,Liu, M.,Wang, L.,Zu, Y.,Wu, C.,Li, C.,Zhang, R.,Lu, H.,Li, F.,Xi, S.,Chen, S.,Gu, X.,Liu, T.,Cai, J.,Wang, S.,Yang, M.,Xing, G.G.,Xiong, W.,Hua, L.,Tang, Y.,Wang, G. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res. 2022 32 570 584 7F5W 34858455 Conserved and divergent strigolactone signaling in Saccharum spontaneum 2021-06-23 2022-05-04 Hu, A.,Zhao, Q.,Chen, L.,Zhao, J.,Wang, Y.,Feng, K.,Wu, L.,Xie, M.,Zhou, X.,Xiao, L.,Ming, Z.,Zhang, M.,Yao, R. Identification of Conserved and Divergent Strigolactone Receptors in Sugarcane Reveals a Key Residue Crucial for Plant Branching Control. Front Plant Sci 2021 12 747160 747160 7VOB 35238201 The crystal structure of a Radical SAM Enzyme BlsE involved in the Biosynthesis of Blasticidin S 2021-10-13 2022-05-04 Lee, Y.H.,Hou, X.,Chen, R.,Feng, J.,Liu, X.,Ruszczycky, M.W.,Gao, J.M.,Wang, B.,Zhou, J.,Liu, H.W. Radical S -Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S. J.Am.Chem.Soc. 2022 144 4478 4486 7VOC 35238201 The crystal structure of a Radical SAM Enzyme BlsE involved in the Biosynthesis of Blasticidin S 2021-10-13 2022-05-04 Lee, Y.H.,Hou, X.,Chen, R.,Feng, J.,Liu, X.,Ruszczycky, M.W.,Gao, J.M.,Wang, B.,Zhou, J.,Liu, H.W. Radical S -Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S. J.Am.Chem.Soc. 2022 144 4478 4486 7XFD Polysaccharide export protein Wza 2022-04-01 2022-05-04 Wang, B.,Zheng, J. polysaccharide export protein Wza To Be Published 0 0 0 0 7XFF Polysaccharide export protein Wza 2022-04-01 2022-05-04 Wang, B.,Zheng, J. Polysaccharide export protein Wza To Be Published 0 0 0 0 7EJI Crystal structure of KRED F147L/L153Q/Y190P/L199A/M205F/M206F variant and methyl methacrylate complex 2021-04-02 2022-05-11 Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H. Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition Nat Catal 2022 0 0 0 7EJI Crystal structure of KRED F147L/L153Q/Y190P/L199A/M205F/M206F variant and methyl methacrylate complex 2021-04-02 2022-05-11 Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H. Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition Nat Catal 2022 0 0 0 7EQ7 Co-Crystal Structure Analysis of Annexin A2 and 5alpha-EAL 2021-04-30 2022-05-11 Liu, X.,Yang, G. Co-Crystal Structure Analysis of Annexin A2 and 5alpha-EAL To be published 0 0 0 0 7EQH 35689519 Crystal structure of Arabidopsis GUN2/HO1 in complex with heme 2021-05-02 2022-05-11 Wang, J.,Li, X.,Chang, J.W.,Ye, T.,Mao, Y.,Wang, X.,Liu, L. Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase-1. Febs Open Bio 2022 12 1677 1687 7F9H 35325196 complex structure of EnrR-DNA 2021-07-04 2022-05-11 Ma, R.,Liu, Y.,Gan, J.,Qiao, H.,Ma, J.,Zhang, Y.,Bu, Y.,Shao, S.,Zhang, Y.,Wang, Q. Xenogeneic nucleoid-associated EnrR thwarts H-NS silencing of bacterial virulence with unique DNA binding. Nucleic Acids Res. 2022 50 3777 3798 7F9I 35325196 The apo-form structure of EnrR 2021-07-04 2022-05-11 Ma, R.,Liu, Y.,Gan, J.,Qiao, H.,Ma, J.,Zhang, Y.,Bu, Y.,Shao, S.,Zhang, Y.,Wang, Q. Xenogeneic nucleoid-associated EnrR thwarts H-NS silencing of bacterial virulence with unique DNA binding. Nucleic Acids Res. 2022 50 3777 3798 7V9N 35513512 Crystal structure of the lanthipeptide zinc-metallopeptidase EryP from saccharopolyspora erythraea in closed state 2021-08-26 2022-05-11 Zhao, C.,Sheng, W.,Wang, Y.,Zheng, J.,Xie, X.,Liang, Y.,Wei, W.,Bao, R.,Wang, H. Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases. Nat.Chem.Biol. 2022 18 724 732 7V9P 35513512 Crystal structure of the lanthipeptide zinc-metallopeptidase EryP from saccharopolyspora erythraea in intermediate state 2021-08-26 2022-05-11 Zhao, C.,Sheng, W.,Wang, Y.,Zheng, J.,Xie, X.,Liang, Y.,Wei, W.,Bao, R.,Wang, H. Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases. Nat.Chem.Biol. 2022 18 724 732 7VDO Crystal structure of KRED F147L/L153Q/Y190P variant 2021-09-07 2022-05-11 Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H. Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition Nat Catal 2022 0 0 0 7VDO Crystal structure of KRED F147L/L153Q/Y190P variant 2021-09-07 2022-05-11 Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H. Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition Nat Catal 2022 0 0 0 7VE7 Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F 2021-09-08 2022-05-11 Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H. Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition Nat Catal 2022 0 0 0 7VE7 Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F 2021-09-08 2022-05-11 Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H. Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition Nat Catal 2022 0 0 0 7WB2 35415958 Oxidase ChaP-D49L/Y109F mutant 2021-12-15 2022-05-11 Wang, Y.S.,Zheng, W.,Jiang, N.,Jin, Y.X.,Meng, Z.K.,Sun, M.X.,Zong, Y.L.,Xu, T.,Zhu, J.,Tan, R.X. Alteration of the Catalytic Reaction Trajectory of a Vicinal Oxygen Chelate Enzyme by Directed Evolution. Angew.Chem.Int.Ed.Engl. 2022 61 0 0 7VV9 35522713 Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 2021-11-05 2022-05-18 Zheng, Y.,Ding, L.,Meng, X.,Potter, M.,Kearney, A.L.,Zhang, J.,Sun, J.,James, D.E.,Yang, G.,Zhou, C. Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7XAY 35393344 Crystal structure of Hat1-Hat2-Asf1-H3-H4 2022-03-19 2022-05-18 Yue, Y.,Yang, W.S.,Zhang, L.,Liu, C.P.,Xu, R.M. Topography of histone H3-H4 interaction with the Hat1-Hat2 acetyltransferase complex. Genes Dev. 2022 36 408 413 7XKC 35460754 Crystal structure of Daucus Carrot hypoglycemic peptide (DCHP) 2022-04-19 2022-05-18 Hao, Y.,Guo, T.,Ren, J.,Wang, Y.,Wang, L.,Shi, Y.,Feng, W. Characterization of a thermostable, protease-tolerant inhibitor of alpha-glycosidase from carrot: A potential oral additive for treatment of diabetes. Int.J.Biol.Macromol. 2022 209 1271 1279 7EW5 immune complex of HPV6 L1 pentamer and neutralizing antibody 13H5 2021-05-24 2022-06-01 Wang, Z.P.,Wang, D.N.,Gu, Y.,Li, S.W. structure of HPV6 L1 pentamer in complex with neutralizing antibody 13H5 To Be Published 0 0 0 0 7EY1 Bifunctional xylosidase/glucosidase LXYL with intermediate substrate xylose 2021-05-29 2022-06-01 Gong, W.M.,Yang, L.Y. Bifunctional xylosidase/glucosidase LXYL with intermediate substrate xylose To Be Published 0 0 0 0 7EY2 Bifunctional xylosidase/glucosidase LXYL D300N mutant with intermediate substrate xylose 2021-05-29 2022-06-01 Gong, W.M.,Yang, L.Y. Bifunctional xylosidase/glucosidase LXYL with intermediate substrate xylose To Be Published 0 0 0 0 7EZQ Complex structure of AtHPPD with inhibitor Y15832 2021-06-01 2022-06-01 Lin, H.Y.,Yang, G.F. Complex structure of AtHPPD with inhibitor Y18093 To Be Published 0 0 0 0 7W3R 35588869 USP34 catalytic domain 2021-11-26 2022-06-01 Xu, G.,Su, H.,Lu, L.,Liu, X.,Zhao, L.,Tang, B.,Ming, Z. Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34. J.Mol.Biol. 2022 434 167634 167634 7W3U 35588869 USP34 catalytic domain in complex with UbPA 2021-11-26 2022-06-01 Xu, G.,Su, H.,Lu, L.,Liu, X.,Zhao, L.,Tang, B.,Ming, Z. Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34. J.Mol.Biol. 2022 434 167634 167634 7DJK 35798975 Structure of four truncated and mutated forms of quenching protein 2020-11-20 2022-06-08 Yu, G.,Hao, J.,Pan, X.,Shi, L.,Zhang, Y.,Wang, J.,Fan, H.,Xiao, Y.,Yang, F.,Lou, J.,Chang, W.,Malnoe, A.,Li, M. Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH. Nat.Plants 2022 8 840 855 7DJL 35798975 Structure of four truncated and mutated forms of quenching protein 2020-11-20 2022-06-08 Yu, G.,Hao, J.,Pan, X.,Shi, L.,Zhang, Y.,Wang, J.,Fan, H.,Xiao, Y.,Yang, F.,Lou, J.,Chang, W.,Malnoe, A.,Li, M. Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH. Nat.Plants 2022 8 840 855 7F05 Crystal structure of human cardiac calsequestrin bound with calcium 2021-06-03 2022-06-08 Fan, X.X.,Liu, Z.H.,Yu, H.,Liu, X.Y.,Li, L.L.,Wang, L.P.,Li, H.T.,Huang, X.Y.,Xu, Z.,Su, X.D.,Song, C.,Guo, X.F.,Wang, S.Q. Ca2+-dependent Formation of a Non-transmembrane Channel in a Calsequestrin-2 Dimer To Be Published 0 0 0 0 7VP9 35905743 Crystal structure of human ClpP in complex with ZG111 2021-10-15 2022-06-08 Wang, P.,Zhang, T.,Wang, X.,Xiao, H.,Li, H.,Zhou, L.L.,Yang, T.,Wei, B.,Zhu, Z.,Zhou, L.,Yang, S.,Lu, X.,Zhang, Y.,Huang, Y.,Gan, J.,Yang, C.G. Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma. Cell Chem Biol 2022 29 1396 0 7WWZ 35513563 BRD4-BD1 complexed with NEO2734 2022-02-14 2022-06-08 Ji, D.,Shang, G.,Wei, E.,Jia, Y.,Wang, C.,Zhang, Q.,Zeng, L. Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer. Oncogene 2022 41 3251 3262 7WX2 35513563 CBP-BrD complexed with NEO2734 2022-02-14 2022-06-08 Ji, D.,Shang, G.,Wei, E.,Jia, Y.,Wang, C.,Zhang, Q.,Zeng, L. Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer. Oncogene 2022 41 3251 3262 7E9M Crystal Structure of Spindlin1 bound to SPINDOC Docpep3 2021-03-04 2022-06-15 Zhao, F.,Li, H. Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published 0 0 0 0 7EA1 Crystal Structure of Spindlin1 bound to SPINDOC Docpep2 2021-03-05 2022-06-15 Zhao, F.,Li, H. Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published 0 0 0 0 7F08 Crystal Structure of K8 2021-06-03 2022-06-15 Huang, S.X.,Yan, Y.J. Crystal Structure of K8 To Be Published 0 0 0 0 7F0E Crystal Structure of EnPKS2 2021-06-03 2022-06-15 Huang, S.X.,Yan, Y.J. Crystal Structure of EnPKS2 To Be Published 0 0 0 0 7F0G Crystal Structure of EnPKS1 2021-06-04 2022-06-15 Huang, S.X.,Yan, Y.J. Crystal Structure of EnPKS1 To Be Published 0 0 0 0 7F0X A SARS-CoV-2 neutralizing antibody 2021-06-07 2022-06-15 Zhang, G.,Li, X.,Guo, Y.,Wang, Y.,Yuan, S. A SARS-CoV-2 neutralizing antibody To Be Published 0 0 0 0 7F12 A SARS-CoV-2 neutralizing antibody 2021-06-07 2022-06-15 Zhang, G.,Li, X.,Guo, Y.,Wang, Y.,Yuan, S. A SARS-CoV-2 neutralizing antibody To Be Published 0 0 0 0 7F15 A SARS-CoV-2 neutralizing antibody 2021-06-07 2022-06-15 Zhang, G.,Li, X.,Guo, Y.,Wang, Y.,Yuan, S. A SARS-CoV-2 neutralizing antibody To Be Published 0 0 0 0 7FJT 35758665 Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM) 2021-08-04 2022-06-15 Jia, H.,Zhong, Y.,Peng, C.,Gong, P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol. 2022 96 0 0 7V1D 35758665 Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH and GpppA) 2021-08-04 2022-06-15 Jia, H.,Zhong, Y.,Peng, C.,Gong, P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol. 2022 96 0 0 7V1E 35758665 Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH and m7GpppAmG) 2021-08-04 2022-06-15 Jia, H.,Zhong, Y.,Peng, C.,Gong, P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol. 2022 96 0 0 7V1F 35758665 Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM and GTP) 2021-08-04 2022-06-15 Jia, H.,Zhong, Y.,Peng, C.,Gong, P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol. 2022 96 0 0 7V1H 35758665 Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM and m7GTP) 2021-08-04 2022-06-15 Jia, H.,Zhong, Y.,Peng, C.,Gong, P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol. 2022 96 0 0 7V1I 35758665 Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (with an m7GMP-Arg28 adduct and in complex with SAH) 2021-08-04 2022-06-15 Jia, H.,Zhong, Y.,Peng, C.,Gong, P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol. 2022 96 0 0 7V1J 35758665 Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH and m7GpppA) 2021-08-04 2022-06-15 Jia, H.,Zhong, Y.,Peng, C.,Gong, P. Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol. 2022 96 0 0 7EDS Human p53 core domain with germline hot spot mutation M133T in complex with the natural PIG3 p53-response element and Arsenic 2021-03-17 2022-06-22 Xing, Y.F.,Lu, M. Arsenic-bound p53 Hotspot mutant M133T in complex with the natural PIG3 p53-response element To Be Published 0 0 0 0 7F41 PARP15 catalytic domain in complex with 3-AMINOBENZAMIDE 2021-06-17 2022-06-22 Zhou, X.L.,Zhong, F.L.,Li, J.,Zhang, J. PARP15 catalytic domain in complex with 3-AMINOBENZAMIDE To Be Published 0 0 0 0 7F42 PARP15 catalytic domain in complex with Iniparib 2021-06-17 2022-06-22 Zhou, X.L.,Zhou, H.,Li, J.,Zhang, J. PARP15 catalytic domain in complex with Iniparib To Be Published 0 0 0 0 7F43 PARP15 catalytic domain in complex with Niraparib 2021-06-17 2022-06-22 Zhou, X.L.,Zhou, H.,Li, J.,Zhang, J. PARP15 catalytic domain in complex with Niraparib To Be Published 0 0 0 0 7FFM 35690040 Human serum transferrin with five osmium binding sites 2021-07-23 2022-06-22 Wang, M.,Wang, H.,Xu, X.,Lai, T.P.,Zhou, Y.,Hao, Q.,Li, H.,Sun, H. Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake. J.Inorg.Biochem. 2022 234 111885 111885 7FFU 35690040 Osmium-bound human serum transferrin 2021-07-23 2022-06-22 Wang, M.,Wang, H.,Xu, X.,Lai, T.P.,Zhou, Y.,Hao, Q.,Li, H.,Sun, H. Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake. J.Inorg.Biochem. 2022 234 111885 111885 7F70 36750726 Crystal structure of Rv3094c 2021-06-26 2022-06-29 Wan, L.,Hu, P.,Zhang, L.,Wang, Z.X.,Fleming, J.,Ni, B.,Luo, J.,Guan, C.X.,Bai, L.,Tan, Y.,Liu, H.,Li, N.,Xiao, T.,Bai, H.,Zhang, Y.A.,Zhang, X.E.,Wan, K.,Bi, L.,Ouyang, S.,Zhang, H. Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol 2023 6 156 156 7F74 36750726 Rv3094c in complex with FMN. 2021-06-27 2022-06-29 Wan, L.,Hu, P.,Zhang, L.,Wang, Z.X.,Fleming, J.,Ni, B.,Luo, J.,Guan, C.X.,Bai, L.,Tan, Y.,Liu, H.,Li, N.,Xiao, T.,Bai, H.,Zhang, Y.A.,Zhang, X.E.,Wan, K.,Bi, L.,Ouyang, S.,Zhang, H. Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol 2023 6 156 156 7V4Y 35276293 TTHA1264/TTHA1265 complex 2021-08-16 2022-06-29 Xu, M.,Xu, Q.,Wang, M.,Qiu, S.,Xu, D.,Zhang, W.,Wang, W.,He, J.,Wang, Q.,Ran, T.,Sun, B. Crystal structures of TTHA1265 and TTHA1264/TTHA1265 complex reveal an intrinsic heterodimeric assembly. Int.J.Biol.Macromol. 2022 207 424 433 7VKB 35882877 Crystal structure of the a bacterial kinase complex 2021-09-29 2022-06-29 Zhen, X.,Wu, Y.,Ge, J.,Fu, J.,Ye, L.,Lin, N.,Huang, Z.,Liu, Z.,Luo, Z.Q.,Qiu, J.,Ouyang, S. Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila. Nat Commun 2022 13 4333 4333 7VKC 35882877 Crystal structure of a bacterial Ser/Thr kinase 2021-09-29 2022-06-29 Zhen, X.,Wu, Y.,Ge, J.,Fu, J.,Ye, L.,Lin, N.,Huang, Z.,Liu, Z.,Luo, Z.Q.,Qiu, J.,Ouyang, S. Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila. Nat Commun 2022 13 4333 4333 7WDL 35644318 Fungal immunomodulatory protein FIP-nha 2021-12-22 2022-06-29 Liu, Y.,Bastiaan-Net, S.,Zhang, Y.,Hoppenbrouwers, T.,Xie, Y.,Wang, Y.,Wei, X.,Du, G.,Zhang, H.,Imam, K.M.D.S.U.,Wichers, H.,Li, Z. Linking the thermostability of FIP-nha (Nectria haematococca) to its structural properties. Int.J.Biol.Macromol. 2022 213 555 564 7WDL 35644318 Fungal immunomodulatory protein FIP-nha 2021-12-22 2022-06-29 Liu, Y.,Bastiaan-Net, S.,Zhang, Y.,Hoppenbrouwers, T.,Xie, Y.,Wang, Y.,Wei, X.,Du, G.,Zhang, H.,Imam, K.M.D.S.U.,Wichers, H.,Li, Z. Linking the thermostability of FIP-nha (Nectria haematococca) to its structural properties. Int.J.Biol.Macromol. 2022 213 555 564 7WM3 36528084 hnRNP A2/B1 RRMs in complex with single-stranded DNA 2022-01-14 2022-06-29 Liu, Y.,Abula, A.,Xiao, H.,Guo, H.,Li, T.,Zheng, L.,Chen, B.,Nguyen, H.C.,Ji, X. Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition. J.Mol.Biol. 2022 435 167920 167920 7F8I Crystal structure of HPV6 L1 pentamer 2021-07-02 2022-07-06 Wang, Z.P.,Wang, D.N.,Gu, Y.,Li, S.W. Crystal structure of HPV6 L1 pentamer To Be Published 0 0 0 0 7FAH 36056024 Immune complex of head region of CA09 HA and neutralizing antibody 12H5 2021-07-06 2022-07-06 Li, T.,Chen, J.,Zheng, Q.,Xue, W.,Zhang, L.,Rong, R.,Zhang, S.,Wang, Q.,Hong, M.,Zhang, Y.,Cui, L.,He, M.,Lu, Z.,Zhang, Z.,Chi, X.,Li, J.,Huang, Y.,Wang, H.,Tang, J.,Ying, D.,Zhou, L.,Wang, Y.,Yu, H.,Zhang, J.,Gu, Y.,Chen, Y.,Li, S.,Xia, N. Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun 2022 13 5182 5182 7V67 35900099 Crystal Structure of Enolase1 from Candida albicans 2021-08-19 2022-07-06 Li, L.,Lu, H.,Zhang, X.,Whiteway, M.,Wu, H.,Tan, S.,Zang, J.,Tian, S.,Zhen, C.,Meng, X.,Li, W.,Zhang, D.,Zhang, M.,Jiang, Y. Baicalein Acts against Candida albicans by Targeting Eno1 and Inhibiting Glycolysis. Microbiol Spectr 2022 10 0 0 7VAA Crystal structure of MiCGT(W93V/V124F/ F191A/R282H) in complex with UDPs 2021-08-27 2022-07-06 Wen, Z.,Zhang, Z.M.,Zhong, L.,Fan, J.,Li, M.,Ma, Y.,Zhou, Y.,Zhang, W.,Guo, B.,Chen, B.,Wang, J.B. Directed Evolution of a Plant Glycosyltransferase for Chemo- and Regioselective Glycosylation of Pharmaceutically Significant Flavonoids Acs Catalysis 2021 11 14781 14790 7VBE 1.6 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 5.0 2021-08-31 2022-07-06 Zhou, X.L.,Zhong, F.L.,Li, J.,Zhang, J. 1.6 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 5.0 To Be Published 0 0 0 0 7VBF 1.3 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 8.5 2021-08-31 2022-07-06 Zhou, X.L.,Zhong, F.L.,Li, J.,Zhang, J. 1.3 Angstrom Resolution Crystal Structure of SARS-CoV-2 Nucleocapsid dimerization domain, pH 8.5 To Be Published 0 0 0 0 7VLN 35704853 NSD2-PWWP1 domain bound with an imidazol-5-yl benzonitrile compound 2021-10-05 2022-07-06 Li, N.,Yang, H.,Liu, K.,Zhou, L.,Huang, Y.,Cao, D.,Li, Y.,Sun, Y.,Yu, A.,Du, Z.,Yu, F.,Zhang, Y.,Wang, B.,Geng, M.,Li, J.,Xiong, B.,Xu, S.,Huang, X.,Liu, T. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J.Med.Chem. 2022 65 9459 9477 7VRD 35900099 Crystal structure of Enolase1 from Candida albicans complexed with 2'-phosphoglyceric acid sodium 2021-10-22 2022-07-06 Li, L.,Lu, H.,Zhang, X.,Whiteway, M.,Wu, H.,Tan, S.,Zang, J.,Tian, S.,Zhen, C.,Meng, X.,Li, W.,Zhang, D.,Zhang, M.,Jiang, Y. Baicalein Acts against Candida albicans by Targeting Eno1 and Inhibiting Glycolysis. Microbiol Spectr 2022 10 0 0 7W0W 35858353 The novel membrane-proximal sensing mechanism in a broad-ligand binding chemoreceptor McpA of Bacillus velezensis 2021-11-18 2022-07-06 Feng, H.,Lv, Y.,Krell, T.,Fu, R.,Liu, Y.,Xu, Z.,Du, W.,Shen, Q.,Zhang, N.,Zhang, R. Signal binding at both modules of its dCache domain enables the McpA chemoreceptor of Bacillus velezensis to sense different ligands. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7WCV 35793358 Co-crystal structure of FTO bound to 6e 2021-12-20 2022-07-06 Liu, Z.,Duan, Z.,Zhang, D.,Xiao, P.,Zhang, T.,Xu, H.,Wang, C.H.,Rao, G.W.,Gan, J.,Huang, Y.,Yang, C.G.,Dong, Z. Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors. J.Med.Chem. 2022 65 10638 10654 7WWF 35816546 Crystal structure of BioH3 from Mycolicibacterium smegmatis 2022-02-12 2022-07-06 Xu, Y.,Yang, J.,Li, W.,Song, S.,Shi, Y.,Wu, L.,Sun, J.,Hou, M.,Wang, J.,Jia, X.,Zhang, H.,Huang, M.,Lu, T.,Gan, J.,Feng, Y. Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target. Plos Pathog. 2022 18 0 0 7X0E 35354859 Structure of Pseudomonas NRPS protein, AmbB-TC in apo form 2022-02-22 2022-07-06 Chu Yuan Kee, M.J.,Bharath, S.R.,Wee, S.,Bowler, M.W.,Gunaratne, J.,Pan, S.,Zhang, L.,Song, H. Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB. Sci Rep 2022 12 5353 5353 7XHJ 35744678 Crystal structure of RuvC from Deinococcus radiodurans 2022-04-08 2022-07-06 Qin, C.,Han, W.,Xu, Y.,Zhao, Y.,Xu, H.,Tian, B.,Wang, L.,Hua, Y. Structural and Functional Characterization of the Holliday Junction Resolvase RuvC from Deinococcus radiodurans. Microorganisms 2022 10 0 0 7F72 36750726 Rv3094c in complex with FAD and ETH. 2021-06-27 2022-07-13 Wan, L.,Hu, P.,Zhang, L.,Wang, Z.X.,Fleming, J.,Ni, B.,Luo, J.,Guan, C.X.,Bai, L.,Tan, Y.,Liu, H.,Li, N.,Xiao, T.,Bai, H.,Zhang, Y.A.,Zhang, X.E.,Wan, K.,Bi, L.,Ouyang, S.,Zhang, H. Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol 2023 6 156 156 7FC6 35917815 Crystal structure of SARS-CoV RBD and horse ACE2 2021-07-13 2022-07-13 Lan, J.,Chen, P.,Liu, W.,Ren, W.,Zhang, L.,Ding, Q.,Zhang, Q.,Wang, X.,Ge, J. Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2. Structure 2022 30 1432 0 7FCC IL-1RAcPb TIR domain 2021-07-14 2022-07-20 Zhou, J.,Xiao, Y.,Ren, Y.,Ge, J.,Wang, X. Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience 2022 25 104508 0 7FCH IL-18Rbeta TIR domain 2021-07-14 2022-07-20 Zhou, J.,Xiao, Y.,Ren, Y.,Ge, J.,Wang, X. Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience 2022 25 104508 0 7FCJ Zebrafish SIGIRR TIR domain mutant - C299S 2021-07-15 2022-07-20 Zhou, J.,Xiao, Y.,Ren, Y.,Ge, J.,Wang, X. Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience 2022 25 104508 0 7FD3 IL-1RAPL2 TIR domain 2021-07-15 2022-07-20 Zhou, J.,Xiao, Y.,Ren, Y.,Ge, J.,Wang, X. Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience 2022 25 104508 0 7FDL 35995835 Crystal structure of transcription factor WER in complex with EGL3 2021-07-17 2022-07-20 Wang, B.,Luo, Q.,Li, Y.,Du, K.,Wu, Z.,Li, T.,Shen, W.H.,Huang, C.H.,Gan, J.,Dong, A. Structural insights into partner selection for MYB and bHLH transcription factor complexes. Nat.Plants 2021 8 1108 1117 7FDO 35995835 Crystal structure of transcription factor CPC in complex with EGL3 2021-07-17 2022-07-20 Wang, B.,Luo, Q.,Li, Y.,Du, K.,Wu, Z.,Li, T.,Shen, W.H.,Huang, C.H.,Gan, J.,Dong, A. Structural insights into partner selection for MYB and bHLH transcription factor complexes. Nat.Plants 2021 8 1108 1117 7WOJ 35788007 Crystal structure of HSA-Myr complex soaked with cisplatin for one week 2022-01-21 2022-07-20 Chen, S.L.,Yuan, C.,Jiang, L.G.,Luo, Z.P.,Huang, M.D. Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid. Int.J.Biol.Macromol. 2022 216 172 178 7WOK 35788007 Crystal structure of HSA soaked with cisplatin for one week 2022-01-21 2022-07-20 Chen, S.L.,Yuan, C.,Jiang, L.G.,Luo, Z.P.,Huang, M.D. Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid. Int.J.Biol.Macromol. 2022 216 172 178 7XGB 35787554 Crystal structure of the ctcP from Streptomyces aureofaciens 2022-04-04 2022-07-20 Yin, L. Crystal structure determination of the halogenase CtcP from Streptomyces aureofaciens. Acta Crystallogr.,Sect.F 2022 78 270 275 7Y6B 35861543 Crystal structure of the EscE/EsaH complex 2022-06-18 2022-07-20 Zeng, Z.X.,Liu, L.Y.,Xiao, S.B.,Lu, J.F.,Liu, Y.L.,Li, J.,Zhou, Y.Z.,Liao, L.J.,Li, D.Y.,Zhou, Y.,Nie, P.,Xie, H.X. Secreted in a Type III Secretion System-Dependent Manner, EsaH and EscE Are the Cochaperones of the T3SS Needle Protein EsaG of Edwardsiella piscicida. Mbio 2022 13 0 0 7DZJ 35851837 Fabp protein before hv 2021-01-25 2022-07-27 Liu, X.,Liu, P.,Li, H.,Xu, Z.,Jia, L.,Xia, Y.,Yu, M.,Tang, W.,Zhu, X.,Chen, C.,Zhang, Y.,Nango, E.,Tanaka, R.,Luo, F.,Kato, K.,Nakajima, Y.,Kishi, S.,Yu, H.,Matsubara, N.,Owada, S.,Tono, K.,Iwata, S.,Yu, L.J.,Shen, J.R.,Wang, J. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem. 2022 14 1054 1060 7DZJ 35851837 Fabp protein before hv 2021-01-25 2022-07-27 Liu, X.,Liu, P.,Li, H.,Xu, Z.,Jia, L.,Xia, Y.,Yu, M.,Tang, W.,Zhu, X.,Chen, C.,Zhang, Y.,Nango, E.,Tanaka, R.,Luo, F.,Kato, K.,Nakajima, Y.,Kishi, S.,Yu, H.,Matsubara, N.,Owada, S.,Tono, K.,Iwata, S.,Yu, L.J.,Shen, J.R.,Wang, J. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem. 2022 14 1054 1060 7DZK 35851837 Fabp protein after hv 2021-01-25 2022-07-27 Liu, X.,Liu, P.,Li, H.,Xu, Z.,Jia, L.,Xia, Y.,Yu, M.,Tang, W.,Zhu, X.,Chen, C.,Zhang, Y.,Nango, E.,Tanaka, R.,Luo, F.,Kato, K.,Nakajima, Y.,Kishi, S.,Yu, H.,Matsubara, N.,Owada, S.,Tono, K.,Iwata, S.,Yu, L.J.,Shen, J.R.,Wang, J. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem. 2022 14 1054 1060 7DZK 35851837 Fabp protein after hv 2021-01-25 2022-07-27 Liu, X.,Liu, P.,Li, H.,Xu, Z.,Jia, L.,Xia, Y.,Yu, M.,Tang, W.,Zhu, X.,Chen, C.,Zhang, Y.,Nango, E.,Tanaka, R.,Luo, F.,Kato, K.,Nakajima, Y.,Kishi, S.,Yu, H.,Matsubara, N.,Owada, S.,Tono, K.,Iwata, S.,Yu, L.J.,Shen, J.R.,Wang, J. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem. 2022 14 1054 1060 7DZL 35851837 A69C-M71L mutant of Fabp protein 2021-01-25 2022-07-27 Liu, X.,Liu, P.,Li, H.,Xu, Z.,Jia, L.,Xia, Y.,Yu, M.,Tang, W.,Zhu, X.,Chen, C.,Zhang, Y.,Nango, E.,Tanaka, R.,Luo, F.,Kato, K.,Nakajima, Y.,Kishi, S.,Yu, H.,Matsubara, N.,Owada, S.,Tono, K.,Iwata, S.,Yu, L.J.,Shen, J.R.,Wang, J. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem. 2022 14 1054 1060 7DZL 35851837 A69C-M71L mutant of Fabp protein 2021-01-25 2022-07-27 Liu, X.,Liu, P.,Li, H.,Xu, Z.,Jia, L.,Xia, Y.,Yu, M.,Tang, W.,Zhu, X.,Chen, C.,Zhang, Y.,Nango, E.,Tanaka, R.,Luo, F.,Kato, K.,Nakajima, Y.,Kishi, S.,Yu, H.,Matsubara, N.,Owada, S.,Tono, K.,Iwata, S.,Yu, L.J.,Shen, J.R.,Wang, J. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nat.Chem. 2022 14 1054 1060 7F69 36857448 Crystal structure of WIPI2b in complex with ATG16L1 2021-06-24 2022-07-27 Gong, X.,Wang, Y.,Tang, Y.,Wang, Y.,Zhang, M.,Li, M.,Zhang, Y.,Pan, L. ATG16L1 adopts a dual-binding site mode to interact with WIPI2b in autophagy. Sci Adv 2023 9 0 0 7FCL Zebrafish SIGIRR TIR domain 2021-07-15 2022-07-27 Zhou, J.,Xiao, Y.,Ren, Y.,Ge, J.,Wang, X. Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience 2022 25 104508 0 7EBO 34116094 Crystal structure of a feruloyl esterase LP_0796 from Lactobacillus plantarum 2021-03-10 2022-08-03 Zhang, H.,Wen, B.,Liu, Y.,Du, G.,Wei, X.,Imam, K.M.S.U.,Zhou, H.,Fan, S.,Wang, F.,Wang, Y.,Xin, F. A reverse catalytic triad Asp containing loop shaping a wide substrate binding pocket of a feruloyl esterase from Lactobacillus plantarum. Int.J.Biol.Macromol. 2021 184 92 100 7FGB 36191180 A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus 2021-07-26 2022-08-03 Li, L.,Chai, Y.,Peng, W.,Li, D.,Sun, L.,Gao, G.F.,Qi, J.,Xiao, H.,Liu, W.J.,von Itzstein, M.,Gao, F. Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7FGC 36191180 A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus 2021-07-26 2022-08-03 Li, L.,Chai, Y.,Peng, W.,Li, D.,Sun, L.,Gao, G.F.,Qi, J.,Xiao, H.,Liu, W.J.,von Itzstein, M.,Gao, F. Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7FGD 36191180 A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus 2021-07-26 2022-08-03 Li, L.,Chai, Y.,Peng, W.,Li, D.,Sun, L.,Gao, G.F.,Qi, J.,Xiao, H.,Liu, W.J.,von Itzstein, M.,Gao, F. Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7FGE 36191180 A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus 2021-07-26 2022-08-03 Li, L.,Chai, Y.,Peng, W.,Li, D.,Sun, L.,Gao, G.F.,Qi, J.,Xiao, H.,Liu, W.J.,von Itzstein, M.,Gao, F. Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7FH0 35906408 Crystallographic structure of two neutralizing nanobodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD) 2021-07-28 2022-08-03 Ma, H.,Zhang, X.,Zheng, P.,Dube, P.H.,Zeng, W.,Chen, S.,Cheng, Q.,Yang, Y.,Wu, Y.,Zhou, J.,Hu, X.,Xiang, Y.,Zhang, H.,Chiu, S.,Jin, T. Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron. Cell Res. 2022 32 831 842 7VS7 35568972 Crystal structure of the ectodomain of OsCERK1 in complex with chitin hexamer 2021-10-26 2022-08-03 Xu, L.,Wang, J.,Xiao, Y.,Han, Z.,Chai, J. Structural insight into chitin perception by chitin elicitor receptor kinase 1 of Oryza sativa. J Integr Plant Biol 2023 65 235 248 7FA1 35729072 Crystal Structure of N-terminus of the non-structural protein 2 from SARS coronavirus 2021-07-05 2022-08-10 Lou, Z.,Rao, Z. The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function. Annu.Rev.Biochem. 2022 91 381 401 7V2S 36341863 Crystal structure of juvenile hormone acid methyltransferase JHAMT isoform3 from silkworm 2021-08-09 2022-08-10 Zhang, L.,Xu, H.,Zhang, Y.,Zhang, H.,Wang, Z.,Guo, P.,Zhao, P. Structural characterization and functional analysis of juvenile hormone acid methyltransferase JHAMT3 from the silkworm, Bombyx mori. Insect Biochem.Mol.Biol. 2022 151 103863 103863 7V3R Crystal structure of CMET in complex with a novel inhibitor 2021-08-11 2022-08-17 Zhan, Z.,Ji, Y.,Su, H.,Fang, C.,Peng, X.,Liu, Q.,Dai, Y.,Lin, D.,Xu, Y.,Ai, J.,Duan, W. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase J.Med.Chem. 2023 66 220 234 7V3S Crystal structure of CMET in complex with a novel inhibitor 2021-08-11 2022-08-17 Zhan, Z.,Ji, Y.,Su, H.,Fang, C.,Peng, X.,Liu, Q.,Dai, Y.,Lin, D.,Xu, Y.,Ai, J.,Duan, W. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase J.Med.Chem. 2023 66 220 234 7V55 36216841 Crystal structure of phospholipase D from Pseudomonas aeruginosa PAO1 using in situ proteolysis 2021-08-16 2022-08-17 Yang, X.,Li, Z.,Zhao, L.,She, Z.,Gao, Z.,Sui, S.F.,Dong, Y.,Li, Y. Structural insights into PA3488-mediated inactivation of Pseudomonas aeruginosa PldA. Nat Commun 2022 13 5979 5979 7X8C 35809674 Crystal structure of a KTSC family protein from Euryarchaeon Methanolobus vulcani 2022-03-12 2022-08-17 Tian, L.,Zhu, K.,Chen, Y.,Zheng, X.,Zhang, H.,Geng, Z.,Li, W.,Ding, N.,Chen, J.,Dong, Y.,Cao, P.,Gong, Y.,Zhang, Z. Biochemical and structural characterization of a KTSC family single-stranded DNA-binding protein from Euryarchaea. Int.J.Biol.Macromol. 2022 216 618 628 7PEI Crystal Structure of a Class D carbapenemase_E185A/R186A/R206A 2021-08-10 2022-08-24 Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y. An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci. 2023 0 0 0 7PEI Crystal Structure of a Class D carbapenemase_E185A/R186A/R206A 2021-08-10 2022-08-24 Zhou, Q.,Catalan, P.,Bell, H.,Baumann, P.,Cooke, R.,Evans, R.,Yang, J.,Zhang, Z.,Zappala, D.,Zhang, Y.,Blackburn, G.M.,He, Y.,Jin, Y. An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci. 2023 0 0 0 7VIJ 35947662 Crystal structure of USP7-HUBL domain 2021-09-27 2022-08-24 Zhang, X.W.,Feng, N.,Liu, Y.C.,Guo, Q.,Wang, J.K.,Bai, Y.Z.,Ye, X.M.,Yang, Z.,Yang, H.,Liu, Y.,Yang, M.M.,Wang, Y.H.,Shi, X.M.,Liu, D.,Tu, P.F.,Zeng, K.W. Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Sci Adv 2022 8 0 0 7VBD Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 2021-08-31 2022-08-31 Zeng, P.,Zhou, X.L.,Zhong, F.L.,Li, J.,Zhang, J. Crystal structure of SARS-Cov-2 nucleocapsid N-terminal domain (NTD) protein,pH8.0 To Be Published 0 0 0 0 7VIV Crystal structure of the I73R from African Swine Fever Virus 2021-09-28 2022-09-07 Sun, L.F. Structural insight into African Swine Fever Virus I73R protein reveals it is a Z-DNA binding protein To be published 0 0 0 0 7W66 35966606 Crystal structure of a PSH1 mutant in complex with ligand 2021-12-01 2022-09-14 Pfaff, L.,Gao, J.,Li, Z.,Jackering, A.,Weber, G.,Mican, J.,Chen, Y.,Dong, W.,Han, X.,Feiler, C.G.,Ao, Y.F.,Badenhorst, C.P.S.,Bednar, D.,Palm, G.J.,Lammers, M.,Damborsky, J.,Strodel, B.,Liu, W.,Bornscheuer, U.T.,Wei, R. Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase. Acs Catalysis 2022 12 9790 9800 7W66 35966606 Crystal structure of a PSH1 mutant in complex with ligand 2021-12-01 2022-09-14 Pfaff, L.,Gao, J.,Li, Z.,Jackering, A.,Weber, G.,Mican, J.,Chen, Y.,Dong, W.,Han, X.,Feiler, C.G.,Ao, Y.F.,Badenhorst, C.P.S.,Bednar, D.,Palm, G.J.,Lammers, M.,Damborsky, J.,Strodel, B.,Liu, W.,Bornscheuer, U.T.,Wei, R. Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase. Acs Catalysis 2022 12 9790 9800 7X0G 36069444 Crystal structure of sugar binding protein CbpA from Clostridium thermocellum 2022-02-22 2022-09-14 Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y. Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum. Mbio 2022 13 0 0 7X0I 36069444 Crystal structure of sugar binding protein CbpB from Clostridium thermocellum 2022-02-22 2022-09-14 Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y. Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum. Mbio 2022 13 0 0 7X0N 36069444 Crystal structure of sugar binding protein CbpB complexed wtih laminaribiose from Clostridium thermocellum 2022-02-22 2022-09-14 Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y. Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum. Mbio 2022 13 0 0 7X0O 36069444 Crystal structure of sugar binding protein CbpC from Clostridium thermocellum 2022-02-22 2022-09-14 Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y. Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum. Mbio 2022 13 0 0 7X0P 36069444 Crystal structure of sugar binding protein CbpD from Clostridium thermocellum 2022-02-22 2022-09-14 Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y. Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum. Mbio 2022 13 0 0 7X0Q 36069444 Crystal structure of ATPase Clo1313_2554 from Clostridium thermocellum 2022-02-22 2022-09-14 Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y. Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum. Mbio 2022 13 0 0 7X0R 36069444 Crystal structure of substrate binding protein Lbp complexed wtih guanosine from Clostridium thermocellum 2022-02-22 2022-09-14 Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y. Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum. Mbio 2022 13 0 0 7W7H 36054360 S Suis FakA-FakB2 complex structure 2021-12-04 2022-09-21 Shi, Y.,Zang, N.,Lou, N.,Xu, Y.,Sun, J.,Huang, M.,Zhang, H.,Lu, H.,Zhou, C.,Feng, Y. Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging. Sci Adv 2022 8 0 0 7XCE 35850303 Crystal structure of Ankyrin G in complex with neurofascin 2022-03-24 2022-09-21 He, L.,Jiang, W.,Li, J.,Wang, C. Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment. J.Biol.Chem. 2022 298 102272 102272 7VEO 36341863 Crystal structure of juvenile hormone acid methyltransferase silkworm JHAMT isoform3 complex with S-Adenosyl-L-homocysteine 2021-09-09 2022-09-28 Zhang, L.,Xu, H.,Zhang, Y.,Zhang, H.,Wang, Z.,Guo, P.,Zhao, P. Structural characterization and functional analysis of juvenile hormone acid methyltransferase JHAMT3 from the silkworm, Bombyx mori. Insect Biochem.Mol.Biol. 2022 151 103863 103863 7VJT 36174223 Crystal Structure of Mtb Pks13-TE in complex with inhibitor coumestan derivative 8 2021-09-28 2022-09-28 Zhang, W.,Lun, S.,Wang, S.S.,Cai, Y.P.,Yang, F.,Tang, J.,Bishai, W.R.,Yu, L.F. Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment. J.Med.Chem. 2022 65 13240 13252 7XZ8 36005536 Mutant (K141A) of the N-terminal domain of fucoidan lyase FdlA 2022-06-02 2022-09-28 Wang, J.,Liu, Z.,Pan, X.,Wang, N.,Li, L.,Du, Y.,Li, J.,Li, M. Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082. Mar Drugs 2022 20 0 0 7XZE 36005536 Mutant (H176A) of the N-terminal domain of fucoidan lyase FdlA 2022-06-02 2022-09-28 Wang, J.,Liu, Z.,Pan, X.,Wang, N.,Li, L.,Du, Y.,Li, J.,Li, M. Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082. Mar Drugs 2022 20 0 0 7XZF 36005536 Wild type of the N-terminal domain of fucoidan lyase FdlA 2022-06-02 2022-09-28 Wang, J.,Liu, Z.,Pan, X.,Wang, N.,Li, L.,Du, Y.,Li, J.,Li, M. Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082. Mar Drugs 2022 20 0 0 7Y0C 36493787 Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD 2022-06-04 2022-09-28 Cao, Y.,Jian, F.,Zhang, Z.,Yisimayi, A.,Hao, X.,Bao, L.,Yuan, F.,Yu, Y.,Du, S.,Wang, J.,Xiao, T.,Song, W.,Zhang, Y.,Liu, P.,An, R.,Wang, P.,Wang, Y.,Yang, S.,Niu, X.,Zhang, Y.,Gu, Q.,Shao, F.,Hu, Y.,Yin, W.,Zheng, A.,Wang, Y.,Qin, C.,Jin, R.,Xiao, J.,Xie, X.S. Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep 2022 41 111845 111845 7Y7P 36039765 QDE-1 in complex with RNA template, RNA primer and AMPNPP 2022-06-22 2022-09-28 Cui, R.,Li, H.,Zhao, J.,Li, X.,Gan, J.,Ma, J. Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res. 2022 50 10169 10186 7Y7Q 36039765 QDE-1 in complex with RNA template, RNA primer and 3'-dGTP 2022-06-22 2022-09-28 Cui, R.,Li, H.,Zhao, J.,Li, X.,Gan, J.,Ma, J. Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res. 2022 50 10169 10186 7Y7R 36039765 QDE-1 in complex with DNA template, RNA primer and 3'-dGTP 2022-06-22 2022-09-28 Cui, R.,Li, H.,Zhao, J.,Li, X.,Gan, J.,Ma, J. Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res. 2022 50 10169 10186 7Y7S 36039765 QDE-1 in complex with DNA template, RNA primer and AMPNPP 2022-06-22 2022-09-28 Cui, R.,Li, H.,Zhao, J.,Li, X.,Gan, J.,Ma, J. Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res. 2022 50 10169 10186 7Y7T 36039765 QDE-1 in complex with 12nt DNA template, ATP and 3'-dGTP 2022-06-22 2022-09-28 Cui, R.,Li, H.,Zhao, J.,Li, X.,Gan, J.,Ma, J. Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res. 2022 50 10169 10186 7VKJ Structure of ESRP1 qRRM3 domain 2021-09-30 2022-10-05 Wu, B.X.,Patel, D.J. Structure of ESRP1 qRRM3 domain To Be Published 0 0 0 0 7W29 35481649 Crystal Structure of SETD3-SAH in complex with betaA-Orn73 peptide 2021-11-23 2022-10-05 Hintzen, J.C.J.,Ma, H.,Deng, H.,Witecka, A.,Andersen, S.B.,Drozak, J.,Guo, H.,Qian, P.,Li, H.,Mecinovic, J. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin. Protein Sci. 2022 31 0 0 7XPL 36127125 Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase 2022-05-04 2022-10-05 Wang, J.,Yang, Z.,Ye, K. Methylation guide RNAs without box C/D motifs. Rna 2022 28 1597 1605 7VM4 36039386 Crystal structure of uPA in complex with nafamostat 2021-10-07 2022-10-12 Zhou, Y.,Wu, J.,Xue, G.,Li, J.,Jiang, L.,Huang, M. Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys.J. 2022 121 3940 3949 7X32 36189746 Crystal structure of E. coli NfsB in complex with berberine 2022-02-27 2022-10-12 Wen, H.Y.,Pan, L.B.,Ma, S.R.,Yang, X.Y.,Hu, J.C.,Zhao, H.F.,Gao, Z.Q.,Dong, Y.H.,Wang, Y.,Zhang, H. Structural basis for the transformation of the traditional medicine berberine by bacterial nitroreductase. Acta Crystallogr D Struct Biol 2022 78 1273 1282 7XE8 Crystal structure of imine reductase from Streptomyces albidoflavus 2022-03-30 2022-10-12 Zhang, J.,Li, X.,Chen, R.,Tan, X.,Liu, X.,Ma, Y.,Zhu, F.,An, C.,Wei, G.,Yao, Y.,Yang, L.,Zhang, P.,Wu, Q.,Sun, Z.,Wang, B.G.,Gao, S.S.,Cui, C. Actinomycetes-derived imine reductases with a preference towards bulky amine substrates Commun Chem 2022 5 123 0 8GX9 Crystal structure of SARS-CoV-2 RBD with P2C-1F11 and P2B-1G5 2022-09-19 2022-10-12 Wang, X.,Zhang, L.,Ge, J. Crystal structure of SARS-CoV-2 antibody P2C-1F11 and RBD To be published 0 0 0 0 7VEG 36291642 Understanding NH-pi interaction between Gln and Phe 2021-09-08 2022-10-19 Zhang, R.,Xu, Y.,Lan, J.,Fan, S.,Huang, J.,Xu, F. Structural Achievability of an NH-pi Interaction between Gln and Phe in a Crystal Structure of a Collagen-like Peptide. Biomolecules 2022 12 0 0 7VP1 Structure of a transcription factor and DNA complex 2021-10-15 2022-10-19 Zhang, Y.,Xu, Y.P.,Wang, B.,Su, X.D. Structural basis for DNA recognition by TCP transcription factors To Be Published 0 0 0 0 7VP3 Structure of a transcription factor and DNA complex 2021-10-15 2022-10-19 Zhang, Y.,Xu, Y.P.,Wang, B.,Su, X.D. Structural basis for DNA recognition by TCP transcription factors To Be Published 0 0 0 0 7VP7 Structure of a transcription factor and DNA complex 2021-10-15 2022-10-19 Zhang, Y.,Xu, Y.P.,Wang, B.,Su, X.D. Structural basis for DNA recognition by TCP transcription factors To Be Published 0 0 0 0 7WA9 35444621 Crystal structure of MSMEG_5634 from Mycobacterium smegmatis 2021-12-12 2022-10-19 Li, M.,Huang, Q.,Zhang, W.,Cao, Y.,Wang, Z.,Zhao, Z.,Zhang, X.,Zhang, J. A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis Front Microbiol 2022 13 846722 846722 7YE7 36184694 Crystal structure of SARS-CoV-2 soluble dimeric ORF9b 2022-07-05 2022-10-19 Jin, X.,Sun, X.,Chai, Y.,Bai, Y.,Li, Y.,Hao, T.,Qi, J.,Song, H.,Wong, C.C.L.,Gao, G.F. Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism. Sci China Life Sci 2023 66 152 164 7YE8 36184694 Crystal structure of SARS-CoV-2 refolded dimeric ORF9b 2022-07-05 2022-10-19 Jin, X.,Sun, X.,Chai, Y.,Bai, Y.,Li, Y.,Hao, T.,Qi, J.,Song, H.,Wong, C.C.L.,Gao, G.F. Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism. Sci China Life Sci 2023 66 152 164 8GVI 36130828 The complex between H25-11 TCR and HLA-A24 bound to HIV-1 Nef138-8 peptide 2022-09-15 2022-10-19 Ma, K.,Chai, Y.,Guan, J.,Tan, S.,Qi, J.,Kawana-Tachikawa, A.,Dong, T.,Iwamoto, A.,Shi, Y.,Gao, G.F. Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors. J Immunol. 2022 209 1652 1661 7W06 36333306 Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate (SeMet labeled), Space group C121. 2021-11-17 2022-10-26 Sun, P.,Zhang, Z.,Wang, B.,Liu, C.,Chen, C.,Liu, P.,Li, X. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun 2022 13 6562 6562 7W07 36333306 Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate, Space group C121. 2021-11-17 2022-10-26 Sun, P.,Zhang, Z.,Wang, B.,Liu, C.,Chen, C.,Liu, P.,Li, X. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun 2022 13 6562 6562 7WF9 36103920 Crystal structure of mouse SNX25 RGS domain in space group P41212 2021-12-26 2022-10-26 Zhang, Y.,Chen, R.,Dong, Y.,Zhu, J.,Su, K.,Liu, J.,Xu, J. Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins. J.Mol.Biol. 2022 434 167823 167823 7EQ2 Crystal structure of GDP-bound Rab1a-T75D 2021-04-28 2022-11-02 Zhang, W.,Zhang, Z.,Xiang, Y.,Gu, D.D.,Chen, J.,Chen, Y.,Zhai, S.,Liu, Y.,Jiang, T.,Liu, C.,He, B.,Yan, M.,Wang, Z.,Xu, J.,Cao, Y.L.,Deng, B.,Zeng, D.,Lei, J.,Zhuo, J.,Lei, X.,Long, Z.,Jin, B.,Chen, T.,Li, D.,Shen, Y.,Hu, J.,Gao, S.,Liu, Q. Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis Nat.Struct.Mol.Biol. 2024 0 0 0 7VTK Crystal structure of Glycoside Hydrolases family 64 beta-1,3-glucanase 2021-10-29 2022-11-02 Jiang, Z.Q.,Ma, J.W. Crystal structure of Glycoside Hydrolases family 64 beta-1,3-glucanase To be published 0 0 0 0 7VTL Crystal structure of GH family 64 beta-1,3-glucanase complexed with Laminaritriose 2021-10-29 2022-11-02 Jiang, Z.Q.,Ma, J.W. Crystal structure of GH family 64 beta-1,3-glucanase complexed with Laminaritriose To Be Published 0 0 0 0 7VTM Crystal structure of Glucoside hydrolase family 64 beta-1,3-glucanase complexed with Laminaritetraose 2021-10-29 2022-11-02 Jiang, Z.Q.,Ma, J.W. Crystal structure of Glucoside hydrolase family 64 beta-1,3-glucanase complexed with Laminaritetraose To Be Published 0 0 0 0 7VYX Crystal structure of the selenomethionine(SeMet)-derived Cas12c1 (D969A) ternary complex 2021-11-15 2022-11-02 Zhang, B.,Lin, J.,Perculija, V.,Li, Y.,Lu, Q.,Chen, J.,Ouyang, S. Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system Nucleic Acids Res. 2022 50 11820 11833 7YP3 36189743 Crystal structure of elaiophylin glycosyltransferase in complex with elaiophylin 2022-08-02 2022-11-02 Xu, T.,Gan, Q.,Liu, Q.,Chen, R.,Zhen, X.,Zhang, C.,Liu, J. Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation. Acta Crystallogr D Struct Biol 2022 78 1235 1248 7YP4 36189743 Crystal structure of elaiophylin glycosyltransferase in apo-form 2022-08-02 2022-11-02 Xu, T.,Gan, Q.,Liu, Q.,Chen, R.,Zhen, X.,Zhang, C.,Liu, J. Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation. Acta Crystallogr D Struct Biol 2022 78 1235 1248 7YP5 36189743 Crystal structure of elaiophylin glycosyltransferase in complex with TDP 2022-08-02 2022-11-02 Xu, T.,Gan, Q.,Liu, Q.,Chen, R.,Zhen, X.,Zhang, C.,Liu, J. Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation. Acta Crystallogr D Struct Biol 2022 78 1235 1248 7YP6 36189743 Crystal structure of elaiophylin glycosyltransferase in complex with UDP 2022-08-02 2022-11-02 Xu, T.,Gan, Q.,Liu, Q.,Chen, R.,Zhen, X.,Zhang, C.,Liu, J. Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation. Acta Crystallogr D Struct Biol 2022 78 1235 1248 8GPT 36199277 YFV_E_YD6scFv_postfusion 2022-08-27 2022-11-02 Li, Y.,Chen, Z.,Wu, L.,Dai, L.,Qi, J.,Chai, Y.,Li, S.,Wang, Q.,Tong, Z.,Ma, S.,Duan, X.,Ren, S.,Song, R.,Liang, M.,Liu, W.,Yan, J.,Gao, G.F. A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus. Innovation (N Y) 2022 3 100323 100323 8GPU 36199277 YFV_E_YD6Fab_prefusion 2022-08-27 2022-11-02 Li, Y.,Chen, Z.,Wu, L.,Dai, L.,Qi, J.,Chai, Y.,Li, S.,Wang, Q.,Tong, Z.,Ma, S.,Duan, X.,Ren, S.,Song, R.,Liang, M.,Liu, W.,Yan, J.,Gao, G.F. A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus. Innovation (N Y) 2022 3 100323 100323 7WJ6 36102578 Crystal Structure of the Kinase Domain of a Class III Lanthipeptide Synthetase CurKC 2022-01-05 2022-11-09 Huang, S.,Wang, Y.,Cai, C.,Xiao, X.,Liu, S.,Ma, Y.,Xie, X.,Liang, Y.,Chen, H.,Zhu, J.,Hegemann, J.D.,Yao, H.,Wei, W.,Wang, H. Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions. Angew.Chem.Int.Ed.Engl. 2022 61 0 0 7YW7 Crystal structure of zika virus E protein 2022-08-21 2022-11-09 Wang, x.x.,Yang, Y.X. Crystal structure of zika virus E protein To Be Published 0 0 0 0 7YW8 Crystal structure of zika E protein 2022-08-21 2022-11-09 Wang, X.X.,Yang, Y.X. Crystal structure of zika E protein To Be Published 0 0 0 0 7W9S 36477355 Crystal structure of the enterovirus 71 polymerase elongation complex (C1S3 form) 2021-12-10 2022-11-16 Li, R.,Wang, M.,Gong, P. Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis. Nucleic Acids Res. 2022 50 12389 12399 7WLP 36067323 Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses 2022-01-13 2022-11-16 Chen, J.,Lu, Z.,Gong, W.,Xiao, X.,Feng, X.,Li, W.,Shan, S.,Xu, D.,Zhou, Z. Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7XSJ 36608665 The structure of the Mint1/Munc18-1/syntaxin-1 complex 2022-05-14 2022-11-16 Li, W.,Xing, Y.,Wang, Y.,Xu, T.,Song, E.,Feng, W. A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex. Structure 2023 31 68 0 7W0I Crystal structure of threonine aldolase from Mycobacterium vanbaalenii 2021-11-18 2022-11-23 Wu, B. Crystal structure of threonine aldolase from Mycobacterium vanbaalenii To Be Published 0 0 0 0 7Y4T 36355693 Crystal structure of cMET kinase domain bound by compound 9I 2022-06-16 2022-11-23 Wang, C.,Li, J.,Qu, L.,Tang, X.,Song, X.,Yang, F.,Chen, X.,Lin, Q.,Lin, W.,Zhou, Y.,Tu, Z.,Chen, Y.,Zhang, Z.,Lu, X. Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem. 2022 65 15140 15164 7Y4U 36355693 Crystal structure of cMET kinase domain bound by compound 9Y 2022-06-16 2022-11-23 Wang, C.,Li, J.,Qu, L.,Tang, X.,Song, X.,Yang, F.,Chen, X.,Lin, Q.,Lin, W.,Zhou, Y.,Tu, Z.,Chen, Y.,Zhang, Z.,Lu, X. Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem. 2022 65 15140 15164 7WEK 36351391 Crystal structure of the mouse Wdr47 NTD in complex with the WBR motif form Camsap3. 2021-12-23 2022-11-30 Ren, J.,Li, D.,Liu, J.,Liu, H.,Yan, X.,Zhu, X.,Feng, W. Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation. Cell Rep 2022 41 111589 111589 8BD1 Crystal structure of the RhsPWHH-RhsPI toxin-immunity pair 2022-10-18 2022-11-30 Chao, W.C.H. Crystal structure of the RhsPWHH-RhsPI toxin-immunity pair To Be Published 0 0 0 0 8GRD 36375638 Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 in complex with ADP and Mg 2022-09-01 2022-11-30 Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J. Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction. J.Biol.Chem. 2022 298 102695 102695 7W3Q Crystal structure of RORgamma in complex with natural inverse agonist 2021-11-25 2022-12-07 Tian, S.Y.,Li, Y. Crystal structure of RORgamma in complex with natural inverse agonist To Be Published 0 0 0 0 8GRB 36375638 Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 2022-09-01 2022-12-07 Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J. Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction. J.Biol.Chem. 2022 298 102695 102695 7T5I Crystal Structure of Strictosidine Synthase in complex with R-IPA(2-(1H-indol-3-yl) propan-1-amine) 2021-12-12 2022-12-14 Liu, H.,Panjikar, S.,Futamura, Y.,Shao, N.,Osada, H.,Zou, H. Beta-Branched Tryptamine Provoked Non Sandwich-Like-Mode Catalysis of Strictosidine Synthase to Antimalarial Indole Alkaloids to be published 0 0 0 0 7T5J Crystal Structure of Strictosidine Synthase in complex with S-IPA (2-(1H-indol-3-yl) propan-1-amine) 2021-12-12 2022-12-14 Liu, H.,Panjikar, S.,Futamura, Y.,Shao, N.,Osada, H.,Zou, H. beta-Branched Tryptamine Provoked Non Sandwich-Like-Mode Catalysis of Strictosidine Synthase to Antimalarial Indole Alkaloids to be published 0 0 0 0 7WVR Crystal structure of Talaromyces leycettanus JCM12802 expansin 2022-02-11 2022-12-14 Ding, S.,Liu, X.,Hakulinen, N.,Taherzadeh, M.J.,Wang, Y.,Wang, Y.,Qin, X.,Wang, X.,Yao, B.,Luo, H.,Tu, T. Boosting enzymatic degradation of cellulose using a fungal expansin: Structural insight into the pretreatment mechanism Bioresour Technol 2022 358 127434 0 7WBC Hydroxysteroid dehydrogenase wild-type complexed with NAD+ and (4S)-2-2-methyl-2,4-pentanediol 2021-12-16 2022-12-21 Shi, S.-C.,Zheng, Y.-C.,Xu, J.-H.,Li, C.-X. Hydroxysteroid dehydrogenase wild-type complexed with NAD+ and (4S)-2-2-methyl-2,4-pentanediol To Be Published 0 0 0 0 7WBG 36695776 BF2*1901/RY8 2021-12-16 2022-12-21 Han, L.,Wu, S.,Zhang, T.,Peng, W.,Zhao, M.,Yue, C.,Wen, W.,Cai, W.,Li, M.,Wallny, H.J.,Avila, D.W.,Mwangi, W.,Nair, V.,Ternette, N.,Guo, Y.,Zhao, Y.,Chai, Y.,Qi, J.,Liang, H.,Gao, G.F.,Kaufman, J.,Liu, W.J. A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease. J Immunol. 2023 210 668 680 7WD1 36702124 Crystal structure of R14 bound to SARS-CoV-2 RBD 2021-12-20 2022-12-21 Liu, H.,Wu, L.,Liu, B.,Xu, K.,Lei, W.,Deng, J.,Rong, X.,Du, P.,Wang, L.,Wang, D.,Zhang, X.,Su, C.,Bi, Y.,Chen, H.,Liu, W.J.,Qi, J.,Cui, Q.,Qi, S.,Fan, R.,Jiang, J.,Wu, G.,Gao, G.F.,Wang, Q. Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice. Cell Rep Med 2023 4 100918 100918 7WD2 36702124 Crystal structure of S43 bound to SARS-CoV-2 RBD 2021-12-20 2022-12-21 Liu, H.,Wu, L.,Liu, B.,Xu, K.,Lei, W.,Deng, J.,Rong, X.,Du, P.,Wang, L.,Wang, D.,Zhang, X.,Su, C.,Bi, Y.,Chen, H.,Liu, W.J.,Qi, J.,Cui, Q.,Qi, S.,Fan, R.,Jiang, J.,Wu, G.,Gao, G.F.,Wang, Q. Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice. Cell Rep Med 2023 4 100918 100918 7XD9 36577062 Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form) 2022-03-26 2022-12-21 Wu, J.,Wang, X.,Liu, Q.,Lu, G.,Gong, P. Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA 2023 120 0 0 8GV4 36494358 A human broadly neutralizing influenza A hemagglutinin stem-specific antibody PN-SIA28 2022-09-14 2022-12-21 Chen, Y.,Wang, F.,Yin, L.,Jiang, H.,Lu, X.,Bi, Y.,Zhang, W.,Shi, Y.,Burioni, R.,Tong, Z.,Song, H.,Qi, J.,Gao, G.F. Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun 2022 13 7603 7603 8GV6 36494358 Crystal structure of PN-SIA28 in complex with influenza hemagglutinin H14 (A/long-tailed duck/Wisconsin/10OS3912/2010) 2022-09-14 2022-12-21 Chen, Y.,Wang, F.,Yin, L.,Jiang, H.,Lu, X.,Bi, Y.,Zhang, W.,Shi, Y.,Burioni, R.,Tong, Z.,Song, H.,Qi, J.,Gao, G.F. Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun 2022 13 7603 7603 8GV7 36494358 Crystal structure of PN-SIA28 in complex with influenza hemagglutinin H18 A/flat-faced bat/Peru/033/2010 2022-09-14 2022-12-21 Chen, Y.,Wang, F.,Yin, L.,Jiang, H.,Lu, X.,Bi, Y.,Zhang, W.,Shi, Y.,Burioni, R.,Tong, Z.,Song, H.,Qi, J.,Gao, G.F. Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun 2022 13 7603 7603 7WZV 35622017 The structure of a Twitch Radical SAM Dehydrogenase SpeY 2022-02-19 2022-12-28 Zhang, J.,Hou, X.,Chen, Z.,Ko, Y.,Ruszczycky, M.W.,Chen, Y.,Zhou, J.,Liu, H.W. Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc. 2022 144 9910 9919 7XV8 36651297 Crystal structure of the Human TR4 DNA-Binding Domain Homodimer Bound to DR1 Response Element 2022-05-21 2022-12-28 Liu, Y.,Ma, L.,Li, M.,Tian, Z.,Yang, M.,Wu, X.,Wang, X.,Shang, G.,Xie, M.,Chen, Y.,Liu, X.,Jiang, L.,Wu, W.,Xu, C.,Xia, L.,Li, G.,Dai, S.,Chen, Z. Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation. Nucleic Acids Res. 2023 51 1443 1457 7WH9 35475366 holo structure of emodin 1-OH O-methyltransferase complex with emodin and S-Adenosyl-L-homocysteine 2021-12-30 2023-01-11 Xue, Y.,Liang, Y.,Zhang, W.,Geng, C.,Feng, D.,Huang, X.,Dong, S.,Zhang, Y.,Sun, J.,Qi, F.,Lu, X. Characterization and Structural Analysis of Emodin- O -Methyltransferase from Aspergillus terreus. J.Agric.Food Chem. 2022 70 5728 5737 7WJL 35623387 Crystal structure of S. cerevisiae Hos3 2022-01-07 2023-01-11 Pang, N.,Sun, J.,Che, S.,Yang, N. Structural characterization of fungus-specific histone deacetylase Hos3 provides insights into developing selective inhibitors with antifungal activity. J.Biol.Chem. 2022 298 102068 102068 8F1G 36594833 Crystal structure of human WDR5 in complex with compound WM662 2022-11-05 2023-01-11 Ding, J.,Li, G.,Liu, H.,Liu, L.,Lin, Y.,Gao, J.,Zhou, G.,Shen, L.,Zhao, M.,Yu, Y.,Guo, W.,Hommel, U.,Ottl, J.,Blank, J.,Aubin, N.,Wei, Y.,He, H.,Sage, D.R.,Atadja, P.W.,Li, E.,Jain, R.K.,Tallarico, J.A.,Canham, S.M.,Chiang, Y.L.,Wang, H. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol. 2023 18 34 40 8GQV 36552780 The Crystal Structures of a Swine SLA-2*HB01 Molecules Complexed with a CTL epitope from Asia1 serotype of Foot-and-mouth disease virus 2022-08-31 2023-01-11 Feng, L.,Gao, Y.Y.,Sun, M.,Li, Z.B.,Zhang, Q.,Yang, J.,Qiao, C.,Jin, H.,Feng, H.S.,Xian, Y.H.,Qi, J.,Gao, G.F.,Liu, W.J.,Gao, F.S. The Parallel Presentation of Two Functional CTL Epitopes Derived from the O and Asia 1 Serotypes of Foot-and-Mouth Disease Virus and Swine SLA-2*HB01: Implications for Universal Vaccine Development. Cells 2022 11 0 0 8GQW 36552780 The Crystal Structures of a Swine SLA-2*HB01 Molecules Complexed with a CTL epitope from Asia1 serotype of Foot-and-mouth disease virus 2022-08-31 2023-01-11 Feng, L.,Gao, Y.Y.,Sun, M.,Li, Z.B.,Zhang, Q.,Yang, J.,Qiao, C.,Jin, H.,Feng, H.S.,Xian, Y.H.,Qi, J.,Gao, G.F.,Liu, W.J.,Gao, F.S. The Parallel Presentation of Two Functional CTL Epitopes Derived from the O and Asia 1 Serotypes of Foot-and-Mouth Disease Virus and Swine SLA-2*HB01: Implications for Universal Vaccine Development. Cells 2022 11 0 0 7WL5 Structure of an avian influenza H5 hemagglutinin from the influenza virus A/Equine/Guangxi/25/2010(H5N1) and A/Equine/Guangxi/68/2010(H5N1) 2022-01-12 2023-01-18 Wei, X.,Yang, X.,Chen, Q.,Meng, G. Structure of an avian influenza H5 hemagglutinin from the influenza virus A/Equine/Guangxi/25/2010(H5N1) and A/Equine/Guangxi/68/2010(H5N1) To Be Published 0 0 0 0 7WVD 36494358 Crystal structure of H14 complexed with SIA28 2022-02-10 2023-01-18 Chen, Y.,Wang, F.,Yin, L.,Jiang, H.,Lu, X.,Bi, Y.,Zhang, W.,Shi, Y.,Burioni, R.,Tong, Z.,Song, H.,Qi, J.,Gao, G.F. Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun 2022 13 7603 7603 7WVI 36494358 Crystal structure of SIA28 2022-02-10 2023-01-18 Chen, Y.,Wang, F.,Yin, L.,Jiang, H.,Lu, X.,Bi, Y.,Zhang, W.,Shi, Y.,Burioni, R.,Tong, Z.,Song, H.,Qi, J.,Gao, G.F. Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes. Nat Commun 2022 13 7603 7603 7X88 36272410 Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27 2022-03-11 2023-01-18 Song, L.,Yao, X.,Li, H.,Peng, B.,Boka, A.P.,Liu, Y.,Chen, G.,Liu, Z.,Mathias, K.M.,Xia, L.,Li, Q.,Mir, M.,Li, Y.,Li, H.,Wan, L. Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol.Cell 2022 82 4080 0 7XHF 36279435 Crystal structure of the NTF2L domain of human G3BP1 in complex with the USP10 derived peptide 2022-04-08 2023-01-18 Song, D.,Kuang, L.,Yang, L.,Wang, L.,Li, H.,Li, X.,Zhu, Z.,Shi, C.,Zhu, H.,Gong, W. Yin and yang regulation of stress granules by Caprin-1. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7XHG 36279435 Crystal structure of the NTF2L domain of human G3BP1 in complex with the Caprin-1 derived peptide 2022-04-08 2023-01-18 Song, D.,Kuang, L.,Yang, L.,Wang, L.,Li, H.,Li, X.,Zhu, Z.,Shi, C.,Zhu, H.,Gong, W. Yin and yang regulation of stress granules by Caprin-1. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7WI7 Crystal structure of human MCM8/9 complex 2022-01-03 2023-01-25 Li, J.,Liu, Y. Crystal structure of human MCM8/9 complex To Be Published 0 0 0 0 7WNS Crystal structure of ENF peptide binding protein from Silkworm 2022-01-19 2023-01-25 Guo, P.C.,Zhang, H. Crysatl structure of ENF-peptide binding protein from silkworm, Bombyx mori. To Be Published 0 0 0 0 7WNT RNase J from Mycobacterium tuberculosis 2022-01-19 2023-01-25 Li, J.,Hu, J.,Bao, L.,Zhan, B. Structural ans functional study of RNase J from Mycobacterium tuberculosis To Be Published 0 0 0 0 7YFJ Crystal structure of human WTAP 2022-07-08 2023-01-25 Yan, X.,Pei, K.,Guan, Z.,Liu, F.,Yan, J.,Jin, X.,Wang, Q.,Hou, M.,Tang, C.,Yin, P. AI-empowered integrative structural characterization of m6A methyltransferase complex Cell Res. 2022 32 1124 1127 7YLE 36707613 RnDmpX in complex with DMSP 2022-07-26 2023-01-25 Li, C.Y.,Mausz, M.A.,Murphy, A.,Zhang, N.,Chen, X.L.,Wang, S.Y.,Gao, C.,Aguilo-Ferretjans, M.M.,Silvano, E.,Lidbury, I.D.E.A.,Fu, H.H.,Todd, J.D.,Chen, Y.,Zhang, Y.Z. Ubiquitous occurrence of a dimethylsulfoniopropionate ABC transporter in abundant marine bacteria. Isme J 2023 17 579 587 8HOW 36599124 Crystal structure of AtHPPD-Y191052 complex 2022-12-11 2023-01-25 Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F. Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design. J.Agric.Food Chem. 2023 71 1170 1177 7YJP 36662362 Crystal structure of MCR-1 treated by AuCl 2022-07-20 2023-02-01 Zhang, Q.,Wang, M.,Hu, X.,Yan, A.,Ho, P.L.,Li, H.,Sun, H. Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. J.Biol.Inorg.Chem. 2023 28 225 234 7YJQ 36662362 Crystal structure of MCR-1-S treated by auranofin 2022-07-20 2023-02-01 Zhang, Q.,Wang, M.,Hu, X.,Yan, A.,Ho, P.L.,Li, H.,Sun, H. Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. J.Biol.Inorg.Chem. 2023 28 225 234 7YJR 36662362 Crystal structure of MCR-1-S treated by sodium aurothiomalate 2022-07-20 2023-02-01 Zhang, Q.,Wang, M.,Hu, X.,Yan, A.,Ho, P.L.,Li, H.,Sun, H. Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. J.Biol.Inorg.Chem. 2023 28 225 234 7YJS 36662362 Crystal structure of MCR-1-S treated by sodium aurothiosulfate 2022-07-20 2023-02-01 Zhang, Q.,Wang, M.,Hu, X.,Yan, A.,Ho, P.L.,Li, H.,Sun, H. Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. J.Biol.Inorg.Chem. 2023 28 225 234 7YJT 36662362 Crystal structure of MCR-1-S treated by aurothioglucose 2022-07-20 2023-02-01 Zhang, Q.,Wang, M.,Hu, X.,Yan, A.,Ho, P.L.,Li, H.,Sun, H. Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. J.Biol.Inorg.Chem. 2023 28 225 234 7WZ5 35906001 Larimichthys crocea IFNi 2022-02-17 2023-02-08 Chen, J.,Guan, Y.,Guan, H.,Mu, Y.,Ding, Y.,Zou, J.,Ouyang, S.,Chen, X. Molecular and Structural Basis of Receptor Binding and Signaling of a Fish Type I IFN with Three Disulfide Bonds. J Immunol. 2022 209 806 819 7X80 36690833 The crystal structure of PloI4-C16M/D46A/I137V 2022-03-10 2023-02-08 Wang, H.,Zou, Y.,Li, M.,Tang, Z.,Wang, J.,Tian, Z.,Strassner, N.,Yang, Q.,Zheng, Q.,Guo, Y.,Liu, W.,Pan, L.,Houk, K.N. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem. 2023 15 177 184 7X81 36690833 The crystal structure of PloI4-C16M/D46A/I137V in complex with exo-2+2 adduct 2022-03-10 2023-02-08 Wang, H.,Zou, Y.,Li, M.,Tang, Z.,Wang, J.,Tian, Z.,Strassner, N.,Yang, Q.,Zheng, Q.,Guo, Y.,Liu, W.,Pan, L.,Houk, K.N. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem. 2023 15 177 184 7X86 36690833 The crystal structure of PloI4-F124L in complex with endo-4+2 adduct 2022-03-11 2023-02-08 Wang, H.,Zou, Y.,Li, M.,Tang, Z.,Wang, J.,Tian, Z.,Strassner, N.,Yang, Q.,Zheng, Q.,Guo, Y.,Liu, W.,Pan, L.,Houk, K.N. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem. 2023 15 177 184 7XBR 35866601 Crystal structure of phosphorylated AtMKK5 2022-03-22 2023-02-08 Pei, C.J.,He, Q.X.,Luo, Z.,Yao, H.,Wang, Z.X.,Wu, J.W. Crystal structure of the phosphorylated Arabidopsis MKK5 reveals activation mechanism of MAPK kinases. Acta Biochim.Biophys.Sin. 2022 54 1159 1170 7XG7 Crystal structure of PstS protein from cyanophage Syn19 2022-04-03 2023-02-08 Zhao, F.,Lin, X.,Cai, K.,Jiang, Y.,Ni, T.,Chen, Y.,Feng, J.,Dang, S.,Zhou, C.Z.,Zeng, Q. Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria Environ.Microbiol. 2022 24 3037 3050 7XG7 Crystal structure of PstS protein from cyanophage Syn19 2022-04-03 2023-02-08 Zhao, F.,Lin, X.,Cai, K.,Jiang, Y.,Ni, T.,Chen, Y.,Feng, J.,Dang, S.,Zhou, C.Z.,Zeng, Q. Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria Environ.Microbiol. 2022 24 3037 3050 7XG8 Crystal structure of PstS protein from cyanophage P-SSM2 2022-04-03 2023-02-08 Zhao, F.,Lin, X.,Cai, K.,Jiang, Y.,Ni, T.,Chen, Y.,Feng, J.,Dang, S.,Zhou, C.Z.,Zeng, Q. Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria Environ.Microbiol. 2022 24 3037 3050 7XG8 Crystal structure of PstS protein from cyanophage P-SSM2 2022-04-03 2023-02-08 Zhao, F.,Lin, X.,Cai, K.,Jiang, Y.,Ni, T.,Chen, Y.,Feng, J.,Dang, S.,Zhou, C.Z.,Zeng, Q. Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria Environ.Microbiol. 2022 24 3037 3050 7V2T The complex structure of SoBcmB and its natural precursor 2 2021-08-09 2023-02-15 Zhou, J.H.,Wu, L. The complex structure of SoBcmB and its its natural precursor 2 To Be Published 0 0 0 0 7V3E The complex structure of soBcmB and its intermediate product 1a 2021-08-10 2023-02-15 Wu, L.,Zhou, J.H. The crystal structure of SoBcmB and its side way intermediate product To Be Published 0 0 0 0 7V3N The complex structure of soBcmB-D307A and its natural precursor 2 2021-08-10 2023-02-15 Wu, L.,Zhou, J.H. The complex structure of SoBcmB mutant D307A and its substrate To Be Published 0 0 0 0 7WUZ Structural study of the complex of cblC methylmalonic aciduria and homocysteinuria-related protein MMACHC with cyanocobalamin 2022-02-09 2023-02-15 Feng, Y.,Qin, X. Structural study of the complex of cblC methylmalonic aciduria and homocysteinuria-related protein MMACHC with cyanocobalamin To Be Published 0 0 0 0 7WVS The structure of FinI complex with SAM 2022-02-11 2023-02-15 Lu, J.,Zhou, J. The structure of FinI complex with SAM To Be Published 0 0 0 0 7WW0 The crystal structure of FinI complex with SAH 2022-02-12 2023-02-15 Zhou, J.,Lu, J. The crystal structure of FinI complex with SAH To Be Published 0 0 0 0 7WW4 Crystal structure of multidomain beta-1,3(4)-glucanase 2022-02-12 2023-02-15 Jiang, Z.Q.,Ma, J.W. Crystal structure of multidomain beta-1,3(4)-glucanase To be published 0 0 0 0 8I7L Crystal structure of indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with a novel inhibitor 2023-02-01 2023-02-15 Li, K.,Liu, W.,Dong, X. Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy Journal of Immunology 2022 209 180 191 7WYF Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50 2022-02-16 2023-02-22 Zhu, L.,Li, H. Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with its inhibitor 50 To Be Published 0 0 0 0 7X2P Legionella pneumophila effector RavL 2022-02-26 2023-03-01 Zheng, J.,Lu, Z. Legionella pneumophila effector RavL To Be Published 0 0 0 0 7VA1 Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35 2021-08-27 2023-03-08 Cen, Y.,Gao, D.,Zhou, J.,Tian, P. Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35 To Be Published 0 0 0 0 7X3L 37409679 Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044 2022-03-01 2023-03-08 He, S.,Chu, X.,Wu, Y.,Jiang, J.,Fang, P.,Chen, Y.,Liu, Y.,Qiu, Z.,Xiao, Y.,Li, Z.,Pan, D.,Zhang, Q.,Xie, H.,Xing, S.,Feng, F.,Liu, W.,Guo, Q.,Zhao, L.,Yang, P.,Sun, H. Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem. 2023 66 9537 9560 7X3M 37409679 Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07045 2022-03-01 2023-03-08 He, S.,Chu, X.,Wu, Y.,Jiang, J.,Fang, P.,Chen, Y.,Liu, Y.,Qiu, Z.,Xiao, Y.,Li, Z.,Pan, D.,Zhang, Q.,Xie, H.,Xing, S.,Feng, F.,Liu, W.,Guo, Q.,Zhao, L.,Yang, P.,Sun, H. Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem. 2023 66 9537 9560 7X3O Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07054 2022-03-01 2023-03-08 Jiang, J.,Liu, Y.,He, S.,Chen, Y.,Chu, X.,Liu, Y.,Guo, Q.,Zhao, L.,Feng, F.,Liu, W.,Zhang, X.,Fang, P.,Sun, H. Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07054 To Be Published 0 0 0 0 7X4X 35306364 BTB domain of KEAP1 in complex with MEF 2022-03-03 2023-03-08 Qu, L.,Guo, M.,Zhang, H.,Chen, X.,Wei, H.,Jiang, L.,Li, J.,Chen, Z.,Dai, S.,Chen, Y. Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochem.Biophys.Res.Commun. 2022 605 9 15 7XFR 36857448 Crystal structure of WIPI2b in complex with the second site of ATG16L1 2022-04-02 2023-03-08 Gong, X.,Wang, Y.,Tang, Y.,Wang, Y.,Zhang, M.,Li, M.,Zhang, Y.,Pan, L. ATG16L1 adopts a dual-binding site mode to interact with WIPI2b in autophagy. Sci Adv 2023 9 0 0 8BNV 36838444 Crystal structure of Pif1 from Deferribacter desulfuricans in apo from 2022-11-14 2023-03-08 Rety, S.,Zhang, Y.,Fu, W.,Wang, S.,Chen, W.F.,Xi, X.G. Structural Studies of Pif1 Helicases from Thermophilic Bacteria. Microorganisms 2023 11 0 0 8BNX 36838444 Crystal structure of Pif1 from Deferribacter desulfuricans in complex with AMPPNP 2022-11-14 2023-03-08 Rety, S.,Zhang, Y.,Fu, W.,Wang, S.,Chen, W.F.,Xi, X.G. Structural Studies of Pif1 Helicases from Thermophilic Bacteria. Microorganisms 2023 11 0 0 8HBS 36541770 Crystal of rAlfNmt 2022-10-30 2023-03-08 Wang, Y.,Lin, R.,Liu, M.,Wang, S.,Chen, H.,Zeng, W.,Nie, X.,Wang, S. N -Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus. Microbiol Spectr 2023 11 0 0 7X8U Crystal structure of the N-terminal Solanaceae domain of the Sw-5b NLR immune receptor 2022-03-14 2023-03-22 Li, J.,Xin, J.,Xing, W.,Tao, X. Crystal structure of the N-terminal Solanaceae domain of the Sw-5b NLR immune receptor To Be Published 0 0 0 0 7X9P Crystal structure of human STING complexed with compound BSP17 2022-03-15 2023-03-22 Feng, X.,Pan, L.,Qiang, Z.,Liu, D.,Guan, X.,Feng, L.,Song, B.,Xu, X.,Tan, N.,Ma, Y.,Li, Z.,Wang, Z.,BIan, J. Discovery of Selenium-containing STING agonists as orally available anti tumor agents To be published 0 0 0 0 8BNS 36838444 Crystal structure of Pif1 from Sulfurihydrogenibium sp in complex with ADP 2022-11-14 2023-03-22 Rety, S.,Zhang, Y.,Fu, W.,Wang, S.,Chen, W.F.,Xi, X.G. Structural Studies of Pif1 Helicases from Thermophilic Bacteria. Microorganisms 2023 11 0 0 8I71 36896968 Hepatitis B virus core protein Y132A mutant in complex with Linvencorvir (RG7907), a Hepatitis B Virus (HBV) Core Protein Allosteric Modulator (CpAM) 2023-01-30 2023-03-22 Zhang, W.,Guo, L.,Liu, H.,Wu, G.,Shi, H.,Zhou, M.,Zhang, Z.,Kou, B.,Hu, T.,Zhou, Z.,Xu, Z.,Zhou, X.,Zhou, Y.,Tian, X.,Yang, G.,Young, J.A.T.,Qiu, H.,Ottaviani, G.,Xie, J.,Mayweg, A.V.,Shen, H.C.,Zhu, W. Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection. J.Med.Chem. 2023 66 4253 4270 7XBE co-crystal structure of CcpE-RD with citrate 2022-03-21 2023-03-29 Lan, L.F.,Chen, F.F.,Gan, J.H. co-crystal structure of CcpE-RD with citrate To Be Published 0 0 0 0 7XDV 36774537 Crystal structure of a receptor like kinase from Arabidopsis 2022-03-29 2023-03-29 Kong, Y.,Chen, J.,Jiang, L.,Chen, H.,Shen, Y.,Wang, L.,Yan, Y.,Zhou, H.,Zheng, H.,Yu, F.,Ming, Z. Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun. 2023 4 100559 100559 7XDW 36774537 Crystal structure of a receptor like kinase from Arabidopsis 2022-03-29 2023-03-29 Kong, Y.,Chen, J.,Jiang, L.,Chen, H.,Shen, Y.,Wang, L.,Yan, Y.,Zhou, H.,Zheng, H.,Yu, F.,Ming, Z. Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun. 2023 4 100559 100559 7XDX 36774537 Crystal structure of a receptor like kinase from Arabidopsis 2022-03-29 2023-03-29 Kong, Y.,Chen, J.,Jiang, L.,Chen, H.,Shen, Y.,Wang, L.,Yan, Y.,Zhou, H.,Zheng, H.,Yu, F.,Ming, Z. Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun. 2023 4 100559 100559 7XDY 36774537 Crystal structure of a receptor like kinase from Arabidopsis 2022-03-29 2023-03-29 Kong, Y.,Chen, J.,Jiang, L.,Chen, H.,Shen, Y.,Wang, L.,Yan, Y.,Zhou, H.,Zheng, H.,Yu, F.,Ming, Z. Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation. Plant Commun. 2023 4 100559 100559 8GQR 36869636 Crystal structure of VioD with FAD 2022-08-30 2023-03-29 Xu, M.,Xu, D.,Gao, M.,Zhuang, X.,Wang, W.,Sun, B.,Ran, T. Structural basis for substrate binding and catalytic mechanism of the key enzyme VioD in the violacein synthesis pathway. Proteins 2023 91 956 966 8HJA 36947515 The crystal structure of syn_CdgR-(c-di-GMP) from Synechocystis sp. PCC 6803 2022-11-22 2023-03-29 Zeng, X.,Huang, M.,Sun, Q.X.,Peng, Y.J.,Xu, X.,Tang, Y.B.,Zhang, J.Y.,Yang, Y.,Zhang, C.C. A c-di-GMP binding effector controls cell size in a cyanobacterium. Proc.Natl.Acad.Sci.USA 2023 120 0 0 7XGT Crystal structure of rice OsRNase ZS1 2022-04-06 2023-04-12 Mao, Y.,Gao, F.,Chen, Y.H. Crystal structure of rice OsRNase ZS1 To Be Published 0 0 0 0 7XYQ 37100904 Crystal strucutre of PD-L1 and the computationally designed DBL1_03 protein binder 2022-06-02 2023-04-12 Gainza, P.,Wehrle, S.,Van Hall-Beauvais, A.,Marchand, A.,Scheck, A.,Harteveld, Z.,Buckley, S.,Ni, D.,Tan, S.,Sverrisson, F.,Goverde, C.,Turelli, P.,Raclot, C.,Teslenko, A.,Pacesa, M.,Rosset, S.,Georgeon, S.,Marsden, J.,Petruzzella, A.,Liu, K.,Xu, Z.,Chai, Y.,Han, P.,Gao, G.F.,Oricchio, E.,Fierz, B.,Trono, D.,Stahlberg, H.,Bronstein, M.,Correia, B.E. De novo design of protein interactions with learned surface fingerprints. Nature 2023 617 176 184 7Y01 36541721 Crystal structure of ZmMCM10 in complex with 16nt ssDNA at 2.8. Angstrom resolution 2022-06-03 2023-04-12 Zhao, X.,Wang, J.,Jin, D.,Cheng, J.,Chen, H.,Li, Z.,Wang, Y.,Lou, H.,Zhu, J.K.,Du, X.,Gong, Z. AtMCM10 promotes DNA replication-coupled nucleosome assembly in Arabidopsis. J Integr Plant Biol 2023 65 203 222 8H0M 36869636 Crystal structure of VioD 2022-09-29 2023-04-12 Xu, M.,Xu, D.,Gao, M.,Zhuang, X.,Wang, W.,Sun, B.,Ran, T. Structural basis for substrate binding and catalytic mechanism of the key enzyme VioD in the violacein synthesis pathway. Proteins 2023 91 956 966 7XHH High-resolution X-ray cocrystal structure of USP7 in complex with X4 2022-04-08 2023-04-19 Wen, X.A. High-resolution X-ray cocrystal structure of USP7 in complex with X4 To Be Published 0 0 0 0 8GPS 37097058 Cytoplasmic domain structure of the MgtE Mg2+ channel from Chryseobacterium hispalense 2022-08-27 2023-04-19 Wang, M.,Zhao, Y.,Hayashi, Y.,Ito, K.,Hattori, M. Novel Mg 2+ binding sites in the cytoplasmic domain of the MgtE Mg 2+ channels revealed by X-ray crystal structures. Acta Biochim.Biophys.Sin. 2023 55 683 690 8GPV 37097058 Cytoplasmic domain structure of the MgtE Mg2+ channel from Clostridiales bacterium 2022-08-27 2023-04-19 Wang, M.,Zhao, Y.,Hayashi, Y.,Ito, K.,Hattori, M. Novel Mg 2+ binding sites in the cytoplasmic domain of the MgtE Mg 2+ channels revealed by X-ray crystal structures. Acta Biochim.Biophys.Sin. 2023 55 683 690 8GYN 36898854 zebrafish TIPE1 strucutre in complex with PE 2022-09-23 2023-04-19 Cao, S.,Zhang, Y.,Jiang, H.,Hou, X.,Wang, W. Structural insight into TIPE1 functioning as a lipid transfer protein. J.Biomol.Struct.Dyn. 2023 41 14049 14062 8H7T 36974966 Trans-3/4-proline-hydroxylase H11 apo structure 2022-10-21 2023-04-19 Hu, X.,Huang, X.,Liu, J.,Zheng, P.,Gong, W.,Yang, L. Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol 2023 79 318 325 8H7V 36974966 Trans-3/4-proline-hydroxylase H11 with AKG 2022-10-21 2023-04-19 Hu, X.,Huang, X.,Liu, J.,Zheng, P.,Gong, W.,Yang, L. Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol 2023 79 318 325 8H7Y 36974966 Trans-3/4-proline-hydroxylase H11 with AKG and L-proline 2022-10-21 2023-04-19 Hu, X.,Huang, X.,Liu, J.,Zheng, P.,Gong, W.,Yang, L. Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol 2023 79 318 325 8H81 36974966 Trans-3/4-proline-hydroxylase H11 with 4-Hydroxyl-proline 2022-10-21 2023-04-19 Hu, X.,Huang, X.,Liu, J.,Zheng, P.,Gong, W.,Yang, L. Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol 2023 79 318 325 8H85 36974966 Trans-3/4-proline-hydroxylase H11 with 3-hydroxyl-proline 2022-10-21 2023-04-19 Hu, X.,Huang, X.,Liu, J.,Zheng, P.,Gong, W.,Yang, L. Structures of L-proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation. Acta Crystallogr D Struct Biol 2023 79 318 325 7XCC Crystal Structure of the Disease-Specific Protein of Rice Stripe Virus 2022-03-24 2023-04-26 Wu, Y.K.,Chen, L.F. Crystal Structure of the Disease-Specific Protein of Rice Stripe Virus To Be Published 0 0 0 0 7XCD Crystal Structure of the Disease-Specific Protein of Rice Stripe Virus 2022-03-24 2023-04-26 Wu, Y.K.,Chen, L.F. Crystal Structure of the Disease-Specific Protein of Rice Stripe Virus To Be Published 0 0 0 0 7XM0 Crystal structure of Sau3AI-C and DNA substrate complex 2022-04-23 2023-04-26 Yahui, L.,Feng, Y.,Jianhua, H. The Self-Activation Mechanism of Type IIE Restriction Endonuclease Sau3AI To Be Published 0 0 0 0 7X4L 36358099 Crystal structure of Bacteroides thetaiotaomicron glutamate decarboxylase mutant Y303F-PLP complex 2022-03-02 2023-05-03 Liu, S.,Wen, B.,Du, G.,Wang, Y.,Ma, X.,Yu, H.,Zhang, J.,Fan, S.,Zhou, H.,Xin, F. Coordinated regulation of Bacteroides thetaiotaomicron glutamate decarboxylase activity by multiple elements under different pH. Food Chem 2023 403 134436 134436 7XL7 Function And Structure Research of Salmonella typhimurium Unknown Functional Protein MicN 2022-04-21 2023-05-03 Wang, Q.,Li, B.Q. Function And Structure Research of Salmonella typhimurium Unknown Functional Protein MicN To Be Published 0 0 0 0 7XND 36209956 Crystal structure of Phosphomevalonate kinase from Silkworm 2022-04-28 2023-05-03 Zhang, H.,Liu, J.,Wang, H.,Fang, H.,Zhao, P.,Xia, Q.,Guo, P. Structural insights into the substrate binding of phosphomevalonate kinase from the silkworm, Bombyx mori. Insect Biochem.Mol.Biol. 2022 150 103849 103849 7XPN 36943056 Structure of the Spring Viraemia of Carp Virus Nucleoprotein 2022-05-04 2023-05-17 Wang, Z.X.,Liu, B.,Yang, T.,Yu, D.,Zhang, C.,Zheng, L.,Xie, J.,Liu, B.,Liu, M.,Peng, H.,Lai, L.,Ouyang, Q.,Ouyang, S.,Zhang, Y.A. Structure of the Spring Viraemia of Carp Virus Ribonucleoprotein Complex Reveals Its Assembly Mechanism and Application in Antiviral Drug Screening. J.Virol. 2023 97 0 0 7XQL 36525490 complex structure of LegA15 with GNP 2022-05-07 2023-05-17 Chen, T.T.,Lin, Y.,Zhang, S.,Liu, S.,Song, L.,Zhong, W.,Luo, Z.Q.,Han, A. Atypical Legionella GTPase effector hijacks host vesicular transport factor p115 to regulate host lipid droplet. Sci Adv 2022 8 0 0 7XT1 Crystal structure of Bypass-of-forespore protein C from Bacillus Subtilis 2022-05-15 2023-05-17 Zhang, X.,Sun, G.,Yuan, C.,Jiang, L.,Huang, M. Structural Studies of Bypass of Forespore Protein C from Bacillus Subtilis to Reveal Its Inhibitory Molecular Mechanism for SpoIVB Catalysts 2022 12 0 0 8H56 37171131 Crystal structure of Rep' of porcine circovirus type 2 2022-10-12 2023-05-24 Guan, S.,Tian, A.,Jing, H.,Yuan, H.,Jia, H.,Shi, Y.,Chen, H.,Cao, S.,Peng, G.,Song, Y. Crystal structure of the dimerized of porcine circovirus type II replication-related protein Rep'. Proteins 2023 91 1130 1139 8J8P 37240075 Structure of the four-component Paf1 complex from Saccharomyces eubayanus 2023-05-02 2023-05-24 Qin, Y.,Zhou, Y.,Cao, Y.,Ren, Y.,Deng, P.,Jiang, J.,Wang, Z. Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus . Int J Mol Sci 2023 24 0 0 8JBZ Crystal structure of 3-ketosteroid delta1-dehydrogenase from Rhodococcus erythropolis SQ1 in complex with 4-androstadiene-3,17- dione 2023-05-10 2023-05-31 Hu, Y.L.,Li, X.,Cheng, X.Y.,Song, S.K.,Su, Z.D. Crystal structure of 3-ketosteroid delta1-dehydrogenase from Rhodococcus erythropolis SQ1 in complex with 4-androstadiene-3,17- dione To Be Published 0 0 0 0 7XP9 Phytophthora infesfans RxLR effector AVRvnt1 2022-05-04 2023-06-07 Xing, W.,Hu, Q.,Zhou, J.,Yao, D. Chloroplast Protein GLYK Hijacked by Phytophthora Infestans Effector AVRvnt1 in Cytoplasm to Activate NLR To Be Published 0 0 0 0 7XPC Complex structure of D-glycerate-3-kinase(GLYK) and AVRvnt1 2022-05-04 2023-06-07 Hu, Q.,Zhou, J.,Yao, D.,Xing, W. Chloroplast Protein GLYK Hijacked by Phytophthora Infestans Effector AVRvnt1 in Cytoplasm to Activate NLR To Be Published 0 0 0 0 8HML 37216560 Co-crystal structure of the C terminal DNA binding domain of Saccharopolyspora erythraea GlnR in complex with its conserved promoter DNA in 2.95 Angstrom resolution 2022-12-04 2023-06-07 Shi, J.,Feng, Z.,Xu, J.,Li, F.,Zhang, Y.,Wen, A.,Wang, F.,Song, Q.,Wang, L.,Cui, H.,Tong, S.,Chen, P.,Zhu, Y.,Zhao, G.,Wang, S.,Feng, Y.,Lin, W. Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA 2023 120 0 0 8I6G 37257822 Crystal structure of the African swine fever virus DNA sliding clamp (native form) 2023-01-28 2023-06-07 Wu, J.,Zheng, H.,Gong, P. Crystal structure of African swine fever virus pE301R reveals a ring-shaped trimeric DNA sliding clamp. J.Biol.Chem. 2023 299 104872 104872 8I6H 37257822 Crystal structure of the African swine fever virus DNA sliding clamp (selenomethionine form) 2023-01-28 2023-06-07 Wu, J.,Zheng, H.,Gong, P. Crystal structure of African swine fever virus pE301R reveals a ring-shaped trimeric DNA sliding clamp. J.Biol.Chem. 2023 299 104872 104872 8IIB 37156298 Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta85 mutant (residues 86-546) 2023-02-24 2023-06-07 Fang, X.,Lu, G.,Deng, Y.,Yang, S.,Hou, C.,Gong, P. Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin 2023 38 531 540 8IIC 37156298 Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta40 mutant (residues 41-546) 2023-02-24 2023-06-07 Fang, X.,Lu, G.,Deng, Y.,Yang, S.,Hou, C.,Gong, P. Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin 2023 38 531 540 7XPI 37739943 Structure of a oxidoreductase 2022-05-04 2023-06-14 Lv, Y.,Liang, C.,Sun, Q.,Zhu, J.,Xu, H.,Li, X.,Li, Y.Y.,Wang, Q.,Yuan, H.,Chu, B.,Zhu, D. Structural insights into FSP1 catalysis and ferroptosis inhibition. Nat Commun 2023 14 5933 5933 7XUW Crystal structure of RPA70N-BLMp2 fusion 2022-05-20 2023-06-14 Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C. Structural characterization of human RPA70N association with DNA damage response proteins. Elife 2023 12 0 0 7XV1 Crystal structure of RPA70N-HelB fusion 2022-05-20 2023-06-14 Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C. Structural characterization of human RPA70N association with DNA damage response proteins. Elife 2023 12 0 0 7XX4 37606280 designed glycosyltransferase 2022-05-28 2023-06-14 Zhao, L.,Xu, Y.,Chen, M.,Wu, L.,Li, M.,Lu, Y.,Lu, M.,Chen, Y.,Wu, X. Design of a chimeric glycosyltransferase OleD for the site-specific O-monoglycosylation of 3-hydroxypyridine in nosiheptide. Microb Biotechnol 2023 16 1971 1984 7Y4F 37535747 bacterial DPP4 2022-06-14 2023-06-14 Wang, K.,Zhang, Z.,Hang, J.,Liu, J.,Guo, F.,Ding, Y.,Li, M.,Nie, Q.,Lin, J.,Zhuo, Y.,Sun, L.,Luo, X.,Zhong, Q.,Ye, C.,Yun, C.,Zhang, Y.,Wang, J.,Bao, R.,Pang, Y.,Wang, G.,Gonzalez, F.J.,Lei, X.,Qiao, J.,Jiang, C. Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science 2023 381 0 0 7Y4G 37535747 sit-bound btDPP4 2022-06-14 2023-06-14 Wang, K.,Zhang, Z.,Hang, J.,Liu, J.,Guo, F.,Ding, Y.,Li, M.,Nie, Q.,Lin, J.,Zhuo, Y.,Sun, L.,Luo, X.,Zhong, Q.,Ye, C.,Yun, C.,Zhang, Y.,Wang, J.,Bao, R.,Pang, Y.,Wang, G.,Gonzalez, F.J.,Lei, X.,Qiao, J.,Jiang, C. Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science 2023 381 0 0 8HBM Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA 2022-10-29 2023-06-14 Jiang, L.,Liu, X.,Liang, X.,Dai, S.,Wei, H.,Guo, M.,Chen, Z.,Xiao, D.,Chen, Y. Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA Comput Struct Biotechnol J 2023 21 3149 3157 7Y5M The OTU domain of Tacheng Tick Virus 1 2022-06-17 2023-06-21 Li, Z.,Wang, W.J.,Xiao, Y.S.,Sun, L.T. The OTU domain of Tacheng Tick Virus 1 To Be Published 0 0 0 0 7YTF 37070859 Structure of OCPx2 from Nostoc flagelliforme CCNUN1 2022-08-14 2023-06-21 Yang, Y.W.,Liu, K.,Huang, D.,Yu, C.,Chen, S.Z.,Chen, M.,Qiu, B.S. Functional specialization of expanded orange carotenoid protein paralogs in subaerial Nostoc species. Plant Physiol. 2023 192 2640 2655 7YTH 37070859 Structure of OCPx1 from Nostoc flagelliforme CCNUN1 2022-08-14 2023-06-21 Yang, Y.W.,Liu, K.,Huang, D.,Yu, C.,Chen, S.Z.,Chen, M.,Qiu, B.S. Functional specialization of expanded orange carotenoid protein paralogs in subaerial Nostoc species. Plant Physiol. 2023 192 2640 2655 7YJI 37253620 Crystal structure of Lpg1083 from Legionella pneumophila 2022-07-20 2023-06-28 Gao, J.,Xu, W.,Tang, F.,Xu, M.,Zhou, Q.,Yang, X.,Zhang, N.,Ma, J.,Yang, Q.,Chen, X.,Qin, X.,Ge, H. The bacterial effector SidN/Lpg1083 promotes cell death by targeting Lamin-B2. J Mol Cell Biol 2023 15 0 0 7YTV 37037064 Crystal structure of Aspergillus fumigatus Thioredoxin reductase in complex with auranofin 2022-08-16 2023-06-28 Chen, P.,Yang, J.,Jin, Y.,Lu, C.,Feng, Z.,Gao, F.,Chen, Y.,Wang, F.,Shang, Z.,Lin, W. In vitro antifungal and antibiofilm activities of auranofin against itraconazole-resistant Aspergillus fumigatus. J Mycol Med 2023 33 101381 101381 8G3C 37307526 Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor) 2023-02-07 2023-06-28 Ding, J.,Liu, L.,Chiang, Y.L.,Zhao, M.,Liu, H.,Yang, F.,Shen, L.,Lin, Y.,Deng, H.,Gao, J.,Sage, D.R.,West, L.,Llamas, L.A.,Hao, X.,Kawatkar, S.,Li, E.,Jain, R.K.,Tallarico, J.A.,Canham, S.M.,Wang, H. Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem. 2023 66 8310 8323 8G3E 37307526 Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor) 2023-02-07 2023-06-28 Ding, J.,Liu, L.,Chiang, Y.L.,Zhao, M.,Liu, H.,Yang, F.,Shen, L.,Lin, Y.,Deng, H.,Gao, J.,Sage, D.R.,West, L.,Llamas, L.A.,Hao, X.,Kawatkar, S.,Li, E.,Jain, R.K.,Tallarico, J.A.,Canham, S.M.,Wang, H. Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem. 2023 66 8310 8323 8H0R 37356717 Crystal structure of a cataract-causing crystallin mutant (mouse CRYBB1 Y202X) 2022-09-30 2023-07-05 Jing, X.,Zhu, M.,Lu, X.,Wei, P.,Shi, L.,Zhang, B.Y.,Xu, Y.,Tang, Y.P.,Xiang, D.M.,Gong, P. Cataract-causing Y204X mutation of crystallin protein CRY beta B1 promotes its C-terminal degradation and higher-order oligomerization. J.Biol.Chem. 2023 299 104953 104953 8HIV The structure of apo-SoBcmB with Fe(II) and AKG 2022-11-22 2023-07-05 Wu, L.,Zhou, J.H. The structure of apo-SoBcmB with Fe(II) and AKG To Be Published 0 0 0 0 7YDL Crystal structure of the P450 BM3 heme domain mutant F87A/T268I/A184V/A82T in complex with N-imidazolyl-hexanoyl-L-phenylalanine 2022-07-04 2023-07-12 Dong, S.,Chen, J.,Jiang, Y.,Cong, Z.,Feng, Y. Crystal structure of the P450 BM3 heme domain mutant F87A/T268I/A184V/A82T in complex with N-imidazolyl-hexanoyl-L-phenylalanine To Be Published 0 0 0 0 8GZO 37226442 Crystal structure of collagen heterotrimer with K, D, E, R residuesC 2022-09-27 2023-07-12 Huang, Y.,Lan, J.,Wu, C.,Zhang, R.,Zheng, H.,Fan, S.,Xu, F. Stability of collagen heterotrimer with same charge pattern and different charged residue identities. Biophys.J. 2023 122 2686 2695 8H0E 37226442 Crystal structure of collagen heterotrimer with KD, ER and KE axial pairs 2022-09-28 2023-07-12 Huang, Y.,Lan, J.,Wu, C.,Zhang, R.,Zheng, H.,Fan, S.,Xu, F. Stability of collagen heterotrimer with same charge pattern and different charged residue identities. Biophys.J. 2023 122 2686 2695 8H0F 37226442 Crystal structure of collagen heterotrimer with KD,ER and KE axial pairs 2022-09-28 2023-07-12 Huang, Y.,Lan, J.,Wu, C.,Zhang, R.,Zheng, H.,Fan, S.,Xu, F. Stability of collagen heterotrimer with same charge pattern and different charged residue identities. Biophys.J. 2023 122 2686 2695 8JOJ Crystal structure of 3-ketosteroid delta1-dehydrogenase from Rhodococcus erythropolis SQ1 in complex with 9,11-epoxy-17-hydroxypregn-4-ene-3,20-dione actate 2023-06-07 2023-07-12 Song, S.K.,Hu, Y.L.,Li, X.,Su, Z.D. Crystal structure of 3-ketosteroid delta1-dehydrogenase from Rhodococcus erythropolis SQ1 in complex with 9,11-epoxy-17-hydroxypregn-4-ene-3,20-dione actate To Be Published 0 0 0 0 7Y3Z Structure of a novel carboxylesterase FEH from Acinetobacter sp. DL-2 2022-06-13 2023-07-19 Huang, Y.,Liu, W.D.,Zhang, Y.J.,Duan, Y.J.,Lu, M.L. Structure of a novel carboxylesterase FEH from Acinetobacter sp. DL-2 To Be Published 0 0 0 0 7YD2 37468532 SulE_P44R_S209A 2022-07-03 2023-07-19 Liu, B.,Wang, W.,Qiu, J.,Huang, X.,Qiu, S.,Bao, Y.,Xu, S.,Ruan, L.,Ran, T.,He, J. Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity. Nat Commun 2023 14 4343 4343 7YH5 36937295 MazG(Mycobacterium tuberculosis) 2022-07-12 2023-07-19 Wang, S.,Gao, B.,Chen, A.,Zhang, Z.,Wang, S.,Lv, L.,Zhao, G.,Li, J. Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG from Mycobacterium tuberculosis. Front Microbiol 2023 14 1137279 1137279 7YIK The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii 2022-07-16 2023-07-19 Wang, W.W.,Yi, G.S.,Zhou, H.,Zhao, Y.X.,Wang, Q.S.,He, J.H.,Yu, F.,Xiao, X.,Liu, X.P. The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii To Be Published 0 0 0 0 7YIL The structure of GINS from Methanocaldococcus jannaschii 2022-07-16 2023-07-19 Wang, W.W.,Yi, G.S.,Zhou, H.,Zhao, Y.X.,Wang, Q.S.,He, J.H.,Yu, F.,Xiao, X.,Liu, X.P. The structure of GINS from Methanocaldococcus jannaschii To Be Published 0 0 0 0 8AG1 36139048 Crystal structure of a novel OX40 antibody 2022-07-19 2023-07-19 Zhang, J.,Jiang, X.,Gao, H.,Zhang, F.,Zhang, X.,Zhou, A.,Xu, T.,Cai, H. Structural Basis of a Novel Agonistic Anti-OX40 Antibody. Biomolecules 2022 12 0 0 8HNS 37494395 Crystal structure of an anti-CRISPR protein AcrIIC4 in apo form 2022-12-08 2023-07-19 Sun, W.,Cheng, Z.,Wang, J.,Yang, J.,Li, X.,Wang, J.,Chen, M.,Yang, X.,Sheng, G.,Lou, J.,Wang, Y. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA 2023 120 0 0 8HNT 37494395 Crystal structure of anti-CRISPR protein AcrIIC4 bound to HpaCas9-sgRNA surveillance complex 2022-12-08 2023-07-19 Sun, W.,Cheng, Z.,Wang, J.,Yang, J.,Li, X.,Wang, J.,Chen, M.,Yang, X.,Sheng, G.,Lou, J.,Wang, Y. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA 2023 120 0 0 8HNW 37494395 Crystal structure of HpaCas9-sgRNA surveillance complex bound to double-stranded DNA 2022-12-08 2023-07-19 Sun, W.,Cheng, Z.,Wang, J.,Yang, J.,Li, X.,Wang, J.,Chen, M.,Yang, X.,Sheng, G.,Lou, J.,Wang, Y. AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA 2023 120 0 0 7YG3 35964029 Crystal structure of HLA-B*13:01 2022-07-11 2023-07-26 Jiang, H.,Wang, C.W.,Wang, Z.,Dai, Y.,Zhu, Y.,Lee, Y.S.,Cao, Y.,Chung, W.H.,Ouyang, S.,Wang, H. Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity. J.Biomed.Sci. 2022 29 58 58 7YHN 36511661 ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN 2022-07-14 2023-07-26 Lin, S.,Du, T.,Zhang, J.,Wu, D.,Tian, H.,Zhang, K.,Jiang, L.,Lu, D.,Sheng, L.,Li, Y.,Ji, M.,Chen, X.,Xu, H. Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J.Med.Chem. 2022 65 16372 16391 7YKV The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii 2022-07-24 2023-07-26 Wang, W.W.,Yi, G.S.,Zhou, H.,Zhao, Y.X.,Wang, Q.S.,He, J.H.,Yu, F.,Xiao, X.,Liu, X.P. The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii To Be Published 0 0 0 0 8GT9 37409929 Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs 2022-09-07 2023-07-26 Qiu, X.,Li, N.,Yang, Q.,Wu, S.,Li, X.,Pan, X.,Yamamoto, S.,Zhang, X.,Zeng, J.,Liao, J.,He, C.,Wang, R.,Zhao, Y. The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy 2023 19 2884 2898 8GU7 37409929 Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs 2022-09-11 2023-07-26 Qiu, X.,Li, N.,Yang, Q.,Wu, S.,Li, X.,Pan, X.,Yamamoto, S.,Zhang, X.,Zeng, J.,Liao, J.,He, C.,Wang, R.,Zhao, Y. The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy 2023 19 2884 2898 8HAY 37535747 d4-bound btDPP4 2022-10-27 2023-07-26 Wang, K.,Zhang, Z.,Hang, J.,Liu, J.,Guo, F.,Ding, Y.,Li, M.,Nie, Q.,Lin, J.,Zhuo, Y.,Sun, L.,Luo, X.,Zhong, Q.,Ye, C.,Yun, C.,Zhang, Y.,Wang, J.,Bao, R.,Pang, Y.,Wang, G.,Gonzalez, F.J.,Lei, X.,Qiao, J.,Jiang, C. Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science 2023 381 0 0 8HLL 37463921 Crystal structure of p53/BCL2 fusion complex (complex 1) 2022-11-30 2023-07-26 Wei, H.,Wang, H.,Wang, G.,Qu, L.,Jiang, L.,Dai, S.,Chen, X.,Zhang, Y.,Chen, Z.,Li, Y.,Guo, M.,Chen, Y. Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun 2023 14 4300 4300 7VS2 38409290 secreted fungal effector protein MoErs1 2021-10-25 2023-08-02 Liu, M.,Wang, F.,He, B.,Hu, J.,Dai, Y.,Chen, W.,Yi, M.,Zhang, H.,Ye, Y.,Cui, Z.,Zheng, X.,Wang, P.,Xing, W.,Zhang, Z. Targeting Magnaporthe oryzae effector MoErs1 and host papain-like protease OsRD21 interaction to combat rice blast. Nat.Plants 2024 0 0 0 7YKI 37163606 Crystal structure of MAGI2 PDZ0-GK domain in complex with phospho-SAPAP1 GBR3 peptide 2022-07-22 2023-08-02 Zhang, M.,Cao, A.,Lin, L.,Chen, Y.,Shang, Y.,Wang, C.,Zhang, M.,Zhu, J. Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs. Sci Adv 2023 9 0 0 7YOQ Recj2 and CMP complex from Methanocaldococcus jannaschii 2022-08-02 2023-08-02 Wang, W.W.,Yi, G.S.,Zhou, H.,Zhao, Y.X.,Wang, Q.S.,He, J.H.,Yu, F.,Xiao, X.,Liu, X.P. The structure of nuclease RecJ2 from Methanocaldococcus jannaschii To Be Published 0 0 0 0 7YOR Recj2 and dCMP complex from Methanocaldococcus jannaschii 2022-08-02 2023-08-02 Wang, W.W.,Yi, G.S.,Zhou, H.,Zhao, Y.X.,Wang, Q.S.,He, J.H.,Yu, F.,Xiao, X.,Liu, X.P. The structure of nuclease RecJ2 from Methanocaldococcus jannaschii To Be Published 0 0 0 0 7YOS Recj2 and Mn complex from Methanocaldococcus jannaschii 2022-08-02 2023-08-02 Wang, W.W.,Yi, G.S.,Zhou, H.,Zhao, Y.X.,Wang, Q.S.,He, J.H.,Yu, F.,Xiao, X.,Liu, X.P. The structure of nuclease RecJ2 from Methanocaldococcus jannaschii To Be Published 0 0 0 0 7XVQ Crystal structure of AcrIIC4 2022-05-24 2023-08-09 Zhang, H.,Li, X.Z.,Song, G.Y. a bacteria protein To Be Published 0 0 0 0 7YK4 36139048 ox40-antibody 2022-07-21 2023-08-09 Zhang, J.,Jiang, X.,Gao, H.,Zhang, F.,Zhang, X.,Zhou, A.,Xu, T.,Cai, H. Structural Basis of a Novel Agonistic Anti-OX40 Antibody. Biomolecules 2022 12 0 0 7YO7 Bifunctional xylosidase/glucosidase LXYL with intermediate substrate xylose, 5 seconds 2022-08-01 2023-08-09 Gong, W.M.,Yang, L.Y. Bifunctional xylosidase/glucosidase LXYL with intermediate substrate xylose To Be Published 0 0 0 0 8GZJ 37013991 Crystal structure of Cd2+-bound DNA aptamer 2022-09-27 2023-08-09 Liu, H.,Gao, Y.,Mathivanan, J.,Armour-Garb, Z.,Shao, Z.,Zhang, Y.,Zhao, X.,Shao, Q.,Zhang, W.,Yang, J.,Cao, C.,Li, H.,Sheng, J.,Gan, J. Crystal structures and identification of novel Cd2+-specific DNA aptamer. Nucleic Acids Res. 2023 51 4625 4636 8GZK 37013991 Crystal structure of Cd2+-bound DNA aptamer T10A mutant 2022-09-27 2023-08-09 Liu, H.,Gao, Y.,Mathivanan, J.,Armour-Garb, Z.,Shao, Z.,Zhang, Y.,Zhao, X.,Shao, Q.,Zhang, W.,Yang, J.,Cao, C.,Li, H.,Sheng, J.,Gan, J. Crystal structures and identification of novel Cd2+-specific DNA aptamer. Nucleic Acids Res. 2023 51 4625 4636 7Y5L 37616371 Crystal structure of human CAF-1 core complex in spacegroup C2 2022-06-17 2023-08-16 Liu, C.P.,Yu, Z.,Xiong, J.,Hu, J.,Song, A.,Ding, D.,Yu, C.,Yang, N.,Wang, M.,Yu, J.,Hou, P.,Zeng, K.,Li, Z.,Zhang, Z.,Zhang, X.,Li, W.,Zhang, Z.,Zhu, B.,Li, G.,Xu, R.M. Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science 2023 381 0 0 7Y5O 37616371 Crystal structure of human CAF-1 core complex in spacegroup P21 2022-06-17 2023-08-16 Liu, C.P.,Yu, Z.,Xiong, J.,Hu, J.,Song, A.,Ding, D.,Yu, C.,Yang, N.,Wang, M.,Yu, J.,Hou, P.,Zeng, K.,Li, Z.,Zhang, Z.,Zhang, X.,Li, W.,Zhang, Z.,Zhu, B.,Li, G.,Xu, R.M. Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science 2023 381 0 0 7YKH 37163606 Crystal structure of MAGI2 PDZ0-GK domain in complex with phospho-SAPAP1 GBR2 peptide 2022-07-22 2023-08-16 Zhang, M.,Cao, A.,Lin, L.,Chen, Y.,Shang, Y.,Wang, C.,Zhang, M.,Zhu, J. Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs. Sci Adv 2023 9 0 0 7YTL 37739943 Structure of a oxidoreductase in complex with quinone 2022-08-15 2023-08-23 Lv, Y.,Liang, C.,Sun, Q.,Zhu, J.,Xu, H.,Li, X.,Li, Y.Y.,Wang, Q.,Yuan, H.,Chu, B.,Zhu, D. Structural insights into FSP1 catalysis and ferroptosis inhibition. Nat Commun 2023 14 5933 5933 7YUJ 37831767 Crystal structure of HOIL-1L(365-510) 2022-08-17 2023-08-30 Xu, X.,Wang, Y.,Zhang, Y.,Wang, Y.,Yin, Y.,Peng, C.,Gong, X.,Li, M.,Zhang, Y.,Zhang, M.,Tang, Y.,Zhou, X.,Liu, H.,Pan, L. Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding. Sci Adv 2023 9 0 0 8I16 37729124 Crystal structure of the selenomethionine (SeMet)-derived Cas12g (D513A) mutant 2023-01-12 2023-08-30 Liu, M.,Li, Z.,Chen, J.,Lin, J.,Lu, Q.,Ye, Y.,Zhang, H.,Zhang, B.,Ouyang, S. Structural transitions upon guide RNA binding and their importance in Cas12g-mediated RNA cleavage. Plos Genet. 2023 19 0 0 8J67 37652989 Crystal structure of Toxoplasma gondii M2AP 2023-04-24 2023-08-30 Zhang, S.,Wang, F.,Zhang, D.,Liu, D.,Ding, W.,Springer, T.A.,Song, G. Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii. Commun Biol 2023 6 895 895 8KCZ Crystal structure of 3-ketosteroid delta1-dehydrogenase from Rhodococcus erythropolis SQ1 in complex with 1,4-androstadiene-3,17- dione 2023-08-08 2023-08-30 Song, S.K.,Su, Z.D. Crystal structure of 3-ketosteroid delta1-dehydrogenase from Rhodococcus erythropolis SQ1 in complex with 1,4-androstadiene-3,17- dione To Be Published 0 0 0 0 7X4R Crystal structure of Bacteroides thetaiotaomicron glutamate decarboxylase 2022-03-03 2023-09-13 Liu, S.,Wen, B.,Xin, F. Coordinated regulation of Bacteroides thetaiotaomicron glutamate decarboxylase activity by multiple motifs To Be Published 0 0 0 0 8GQ3 RTT109 mutant from Candida albicans 2022-08-28 2023-09-13 Chen, Y.J.,Su, D. Crystal structure of RTT109 mutant-Y183A from Candida albicans To Be Published 0 0 0 0 8GQ4 Histone acetyltransferase Rtt109 mutant-N195A 2022-08-28 2023-09-13 Chen, Y.J.,Su, D. Structure of Histone acetyltransferase Rtt109 mutant-N195A To Be Published 0 0 0 0 8GTZ Crystal structure of exopolyphosphatase (PPX) mutant E137A from Zymomonas mobilis in complex with magnesium ions 2022-09-09 2023-09-13 Aili, Z.,Lu, Z. Crystal structure of exopolyphosphatase (PPX) from Zymomonas mobilis in complex with magnesium ions To Be Published 0 0 0 0 8H8I 37749089 Triterpenoid saponin acetyltransferase, AmAT7-3 2022-10-22 2023-09-13 Wang, L.,Jiang, Z.,Zhang, J.,Chen, K.,Zhang, M.,Wang, Z.,Wang, B.,Ye, M.,Qiao, X. Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferase from Astragalus membranaceus. Nat Commun 2023 14 5969 5969 8IGT 37674084 Crystal Structure of Intracellular B30.2 Domain of BTN2A1 2023-02-21 2023-09-13 Yuan, L.,Ma, X.,Yang, Y.,Qu, Y.,Li, X.,Zhu, X.,Ma, W.,Duan, J.,Xue, J.,Yang, H.,Huang, J.W.,Yi, S.,Zhang, M.,Cai, N.,Zhang, L.,Ding, Q.,Lai, K.,Liu, C.,Zhang, L.,Liu, X.,Yao, Y.,Zhou, S.,Li, X.,Shen, P.,Chang, Q.,Malwal, S.R.,He, Y.,Li, W.,Chen, C.,Chen, C.C.,Oldfield, E.,Guo, R.T.,Zhang, Y. Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate V gamma 9V delta 2 T cells. Nature 2023 621 840 848 8JJM 37290279 X-ray crystal structure of a multifunctional enzyme (Amy63) from Vibrio alginolyticus 63 2023-05-31 2023-09-13 Sun, Y.,Liu, G.,Liu, G.,Tang, H.,Sun, C.,Zhang, W.,Chen, L. The novel amylase function of the carboxyl terminal domain of Amy63. Biochem.Biophys.Res.Commun. 2023 671 10 17 8GX4 Crystal structure of Diels-Alderase ApiI in complex with SAM 2022-09-18 2023-09-20 Zhou, J.H.,Lu, J.Y. Crystal structure of Diels-Alderase ApiI in complex with SAM To Be Published 0 0 0 0 8J2P 37655965 Crystal structure of PML B-box2 2023-04-15 2023-09-20 Bercier, P.,Wang, Q.Q.,Zang, N.,Zhang, J.,Yang, C.,Maimaitiyiming, Y.,Abou-Ghali, M.,Berthier, C.,Wu, C.,Niwa-Kawakita, M.,Dirami, T.,Geoffroy, M.C.,Ferhi, O.,Quentin, S.,Benhenda, S.,Ogra, Y.,Gueroui, Z.,Zhou, C.,Naranmandura, H.,de The, H.,Lallemand-Breitenbach, V. Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function. Cancer Discov 2023 13 2548 2565 8GY8 The structure of Bax1 from Pyrococcus furiosus 2022-09-21 2023-09-27 Yi, G.S.,Huang, Q.Y.,Wang, W.W.,Yu, F.,Xiao, X.,Liu, X.P. The structure of Bax1 from Pyrococcus furiosus To Be Published 0 0 0 0 8GZI Crystal Structure of ApiI in complex with SAH 2022-09-27 2023-09-27 Zhou, J.H.,Lu, J.Y. Crystal Structure of ApiI in complex with SAH To Be Published 0 0 0 0 8JAB Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-06 2023-05-05 2023-09-27 Zhang, B.,Liang, J.,Rao, Z. Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-06 To Be Published 0 0 0 0 8W59 Crystal structure of the RING domain of human XIAP treated with arsenic trioxide 2023-08-25 2023-09-27 Zhang, Q.,Sun, H. Crystal structure of the RING domain of human XIAP To Be Published 0 0 0 0 8W5A Crystal structure of the RING domain of human XIAP 2023-08-25 2023-09-27 Zhang, Q.,Sun, H. Crystal structure of the RING domain of human XIAP To Be Published 0 0 0 0 7XED Crystal Structure of OsCIE1-Ubox and OsUBC8 complex 2022-03-30 2023-10-04 Zhang, Y.,Yu, C.Z. Release of a Ubiquitin Brake Activates Pattern Recognition Receptor-mediated Immunity in Rice To Be Published 0 0 0 0 8JAA Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04 2023-05-05 2023-10-04 Zhang, B.,Liang, J.,Rao, Z. Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-04 To Be Published 0 0 0 0 8KI5 PhmA, a type I diterpene synthase without NST/DTE motif 2023-08-22 2023-10-04 Zhang, L.,Zhang, B.,Zhu, A.,Liu, S.H.,Wu, R.,Zhang, X.,Xu, Z.R.,Ge, H.M. Biosynthesis of Platelet Activating Factor Antagonist Phomactins Revealing a New Class of Type I Diterpene Synthase To Be Published 0 0 0 0 8G2O 37791598 Fab structure - Anti-ApoE-7C11 antibody 2023-02-06 2023-10-18 Marino, C.,Perez-Corredor, P.,O'Hare, M.,Heuer, A.,Chmielewska, N.,Gordon, H.,Chandrahas, A.S.,Gonzalez-Buendia, L.,Delgado-Tirado, S.,Doan, T.H.,Vanderleest, T.E.,Arevalo-Alquichire, S.,Obar, R.A.,Ortiz-Cordero, C.,Villegas, A.,Sepulveda-Falla, D.,Kim, L.A.,Lopera, F.,Mahley, R.,Huang, Y.,Quiroz, Y.T.,Arboleda-Velasquez, J.F. APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation. Alzheimers Dement 2024 20 819 836 8H4H The apo structure of Aspergillomarasmine A synthetase 2022-10-10 2023-10-18 Lu, M.,Zhang, J.,Wang, Z.,Han, L. The apo structure of Aspergillomarasmine A synthetase at 2.3 Angstroms resolution To Be Published 0 0 0 0 8H4Q Aspergillomarasmine A biosynthese complex with OPS 2022-10-11 2023-10-18 Lu, M.,Zhang, J.,Wang, Z.,Han, L. Aspergillomarasmine A biosynthese complex with OPS To Be Published 0 0 0 0 8HLG 36768763 Crystal structure of MoaE 2022-11-30 2023-10-18 Cai, J.,Zhang, M.,Chen, Z.,Zhao, Y.,Xu, H.,Tian, B.,Wang, L.,Hua, Y. MoaE Is Involved in Response to Oxidative Stress in Deinococcus radiodurans. Int J Mol Sci 2023 24 0 0 8HO6 37304725 ScRIPK WT 2022-12-09 2023-10-18 Fang, J.,Chai, Z.,Huang, R.,Huang, C.,Ming, Z.,Chen, B.,Yao, W.,Zhang, M. Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis. Front Plant Sci 2023 14 1191449 1191449 8HOA 37304725 ScRIPK mutant K124R 2022-12-09 2023-10-18 Fang, J.,Chai, Z.,Huang, R.,Huang, C.,Ming, Z.,Chen, B.,Yao, W.,Zhang, M. Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis. Front Plant Sci 2023 14 1191449 1191449 8HOD 37304725 ScRIPK MUTANT-S253A, T254A 2022-12-09 2023-10-18 Fang, J.,Chai, Z.,Huang, R.,Huang, C.,Ming, Z.,Chen, B.,Yao, W.,Zhang, M. Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis. Front Plant Sci 2023 14 1191449 1191449 8IGY SARS-CoV-2 3CL protease (3CLpro) in complex with nirmatrelvir 2023-02-21 2023-10-18 Jiang, X.,Su, H. Discovery of oral simnotrelvir, an approved SARS-CoV-2 3C-like protease inhibitor for the treatment of COVID-19 To Be Published 0 0 0 0 8H1R Crystal structure of LptDE-YifL complex 2022-10-03 2023-10-25 Luo, Q.,Wang, C.,Qiao, S. Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis To Be Published 0 0 0 0 8H7J The crystal structure of CD163 SRCR5-9 2022-10-20 2023-10-25 Ma, H.F.,Li, R.,Luo, Z.P. The crystal structure of CD163 SRCR5-9 To Be Published 0 0 0 0 8KHU 37801325 Hepatitis B virus core protein Y132A mutant in complex with THPP derivatives 48 2023-08-22 2023-10-25 Kou, B.,Zhang, Z.,Han, X.,Zhou, Z.,Xu, Z.,Zhou, X.,Shen, F.,Zhou, Y.,Tian, X.,Yang, G.,Young, J.A.T.,Qiu, H.,Ottaviani, G.,Mayweg, A.,Zhu, W.,Shen, H.C.,Liu, H.,Hu, T. Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus. J.Med.Chem. 2023 66 14116 14132 8H91 Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with nanobody N19 2022-10-24 2023-11-01 Zhang, Y.T.,Li, J.,Zhang, J. Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with nanobody N19 To Be Published 0 0 0 0 8BH8 Structure of Est1 from Candida Tropicalis in complex with TLC1 telomerase RNA fragment 444-456 2022-10-30 2023-11-08 Rety, S.,Chen, W.F.,Xi, X.G. Structure of Est1 from Candida Tropicalis in complex with TLC1 telomerase RNA fragment 444-456 To Be Published 0 0 0 0 8IVZ 37874676 Crystal structure of talin R7 in complex with KANK1 KN motif 2023-03-29 2023-11-08 Guo, K.,Zhang, J.,Huang, P.,Xu, Y.,Pan, W.,Li, K.,Chen, L.,Luo, L.,Yu, W.,Chen, S.,He, S.,Wei, Z.,Yu, C. KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation. Cell Rep 2023 42 113321 113321 8BH9 Structure of Est1 from Candida Tropicalis in complex with TLC1 telomerase RNA fragment 427-435 / 496-504 2022-10-30 2023-11-15 Rety, S.,Chen, W.F.,Xi, X.G. Structure of Est1 from Candida Tropicalis in complex with TLC1 telomerase RNA fragment 427-435 / 496-504 To Be Published 0 0 0 0 7XRT Bacteroides thetaiotaomicron ferulic acid esterase (BT_4077) 2022-05-11 2023-11-22 Du, G.M.,Wang, Y.L.,Xin, F.J. Insights into the regulatory mechanism of BtFae activity by oligomerization and a distinct substrate binding pocket adjacent to the active site To Be Published 0 0 0 0 8HIG Co-crystal structure of C-terminal DNA binding domain of Saccharopolyspora erythraea GlnR in complex with its cognate promoter DNA 2022-11-20 2023-11-22 Lin, W.,Xu, J.C.,Zhang, Y. Co-crystal structure of C-terminal DNA binding domain of Saccharopolyspora erythraea GlnR in complex with its cognate promoter DNA To Be Published 0 0 0 0 8HTC 37945894 Crystal structure of a SeMet-labeled effector from Chromobacterium violaceum in complex with Ubiquitin 2022-12-21 2023-11-22 Tan, J.,Xu, Y.,Wang, X.,Yan, F.,Xian, W.,Liu, X.,Chen, Y.,Zhu, Y.,Zhou, Y. Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs. Nat.Chem.Biol. 2023 0 0 0 8W4R 37918035 Crystal structure of PDE4D complexed with CVT-313 2023-08-24 2023-11-22 Liu, J.,Zhang, X.,Chen, G.,Shao, Q.,Zou, Y.,Li, Z.,Su, H.,Li, M.,Xu, Y. Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem. 2023 262 115893 115893 8WKH 37926306 Crystal structure of group 13 allergen from Blomia tropicalis 2023-09-27 2023-11-22 Zhou, Y.,Zhu, K.,Li, Q.,Zhou, D.,Ren, Y.,Liao, Y.,Cao, P.,Gong, Y.,Cui, Y. Immunobiological properties and structure analysis of group 13 allergen from Blomia tropicalis and its IgE-mediated cross-reactivity. Int.J.Biol.Macromol. 2023 254 127788 127788 8HNI 36528084 hnRNP A2/B1 RRMs in complex with telomeric DNA 2022-12-07 2023-11-29 Liu, Y.,Abula, A.,Xiao, H.,Guo, H.,Li, T.,Zheng, L.,Chen, B.,Nguyen, H.C.,Ji, X. Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition. J.Mol.Biol. 2023 435 167920 167920 8WMG Structure of ConA/Man3 2023-10-03 2023-12-06 Li, L.,Chen, G. Rational design of inducing ligands with three-dimensional supramolecular interactions to build protein crystalline frameworks. To Be Published 0 0 0 0 8WMK Structure of ConA/Man2 2023-10-03 2023-12-06 Li, L.,Chen, G. Rational design of inducing ligands with three-dimensional supramolecular interactions to build protein crystalline frameworks. To Be Published 0 0 0 0 8HPW Crystal structure of mouse LGI1 LRR domain in space group P21 2022-12-13 2023-12-13 Liu, H.,Xu, F. Crystal structure of mouse LGI1 LRR domain in space group P21 To Be Published 0 0 0 0 8HPX Structure of mouse LGI1 LRR domain in space group P65 2022-12-13 2023-12-13 Liu, H.,Xu, F. Structure of mouse LGI1 LRR domain in space group P65 To Be Published 0 0 0 0 8HPY Crystal structure of human LGI1-ADAM22 complex 2022-12-13 2023-12-13 Liu, H.,Xu, F. Crystal structure of human LGI1-ADAM22 complex To Be Published 0 0 0 0 8XAB Crystal structure of Ubl1 domain of nonstructural protein 3 of SARS-CoV-2 2023-12-03 2023-12-20 Ke, Z.,Zhang, H.,Wang, Y.,Wang, J.N.,Peng, F.,Wang, J.,Liu, X.,Hu, H.,Li, Y. N-terminus of SARS-CoV-2 Nsp3 Interrupts RNA-driven Phase Separation of N Protein by Displacing RNA To Be Published 0 0 0 0 8HDN Brucella melitensis 7-alpha-Hydroxysteroid Dehydrogenase mutant: 1-53 truncation-I258M/K262T 2022-11-05 2023-12-27 Liu, Z.Y.,Zhang, R.Z. Structure of 7-alpha-hydroxysteroid dehydrogenase To Be Published 0 0 0 0 8HS4 Brucella melitensis 7-alpha-Hydroxysteroid Dehydrogenase mutant: 1-53 truncation/K262T-NAD+ 2022-12-17 2023-12-27 Liu, Z.Y.,Zhang, R.Z. Structure of 7-alpha-hydroxysteroid dehydrogenase To Be Published 0 0 0 0 8HS5 Brucella melitensis 7-alpha-Hydroxysteroid Dehydrogenase mutant: 1-53 truncation-I258M/K262T-NAD+ 2022-12-17 2023-12-27 Liu, Z.Y.,Zhang, R.Z. Structure of 7-alpha-hydroxysteroid dehydrogenase To Be Published 0 0 0 0 8HS9 Brucella melitensis 7-alpha-Hydroxysteroid Dehydrogenase mutant:I258M/K262T 2022-12-17 2023-12-27 Liu, Z.Y.,Zhang, R.Z. Structure of 7-alpha-hydroxysteroid dehydrogenase To Be Published 0 0 0 0 8HSA Brucella melitensis 7-alpha-Hydroxysteroid Dehydrogenase mutant: 1-53 truncation/M196I/I258M/K262T-NAD+ 2022-12-18 2023-12-27 Liu, Z.Y.,Zhang, R.Z. Structure of 7-alpha-hydroxysteroid dehydrogenase To Be Published 0 0 0 0 8TBS 38109501 Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator AG-946 2023-06-29 2023-12-27 Liu, T.,Padyana, A.K.,Judd, E.T.,Jin, L.,Hammoudeh, D.,Kung, C.,Dang, L. Structure-Based Design of AG-946, a Pyruvate Kinase Activator. Chemmedchem 2024 19 0 0 8TBT 38109501 Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator Compound 2 2023-06-29 2023-12-27 Liu, T.,Padyana, A.K.,Judd, E.T.,Jin, L.,Hammoudeh, D.,Kung, C.,Dang, L. Structure-Based Design of AG-946, a Pyruvate Kinase Activator. Chemmedchem 2024 19 0 0 8HDI Brucella melitensis 7-alpha-Hydroxysteroid Dehydrogenase mutant: 1-53 truncation/K262T 2022-11-04 2024-01-03 Liu, Z.Y.,Zhang, R.Z. Structure of 7-alpha-hydroxysteroid dehydrogenase To Be Published 0 0 0 0 8HS6 Brucella melitensis 7-alpha-Hydroxysteroid Dehydrogenase mutant:1-53 truncation 2022-12-17 2024-01-03 Liu, Z.Y.,Zhang, R.Z. Structure of 7-alpha-hydroxysteroid dehydrogenase To Be Published 0 0 0 0 8HXR 38062078 Nanobody2 in complex with human BCMA ECD 2023-01-05 2024-01-03 Sun, Y.,Yang, X.N.,Yang, S.S.,Lyu, Y.Z.,Zhang, B.,Liu, K.W.,Li, N.,Cui, J.C.,Huang, G.X.,Liu, C.L.,Xu, J.,Mi, J.Q.,Chen, Z.,Fan, X.H.,Chen, S.J.,Chen, S. Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity. Signal Transduct Target Ther 2023 8 445 445 8ILD 37958741 The crystal structure of native dGTP:DNApre-I:Pol X substrate ternary complex 2023-03-03 2024-01-10 Qin, T.,Hu, B.,Zhao, Q.,Wang, Y.,Wang, S.,Luo, D.,Lyu, J.,Chen, Y.,Gan, J.,Huang, Z. Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom. Int J Mol Sci 2023 24 0 0 8ILD 37958741 The crystal structure of native dGTP:DNApre-I:Pol X substrate ternary complex 2023-03-03 2024-01-10 Qin, T.,Hu, B.,Zhao, Q.,Wang, Y.,Wang, S.,Luo, D.,Lyu, J.,Chen, Y.,Gan, J.,Huang, Z. Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom. Int J Mol Sci 2023 24 0 0 8HOG 38211332 Crystal structure of Bcl-2 in complex with sonrotoclax 2022-12-10 2024-01-17 Liu, J.,Li, S.,Wang, Q.,Feng, Y.,Xing, H.,Yang, X.,Guo, Y.,Guo, Y.,Sun, H.,Liu, X.,Yang, S.,Mei, Z.,Zhu, Y.,Cheng, Z.,Chen, S.,Xu, M.,Zhang, W.,Wan, N.,Wang, J.,Ma, Y.,Zhang, S.,Luan, X.,Xu, A.,Li, L.,Wang, H.,Yang, X.,Hong, Y.,Xue, H.,Yuan, X.,Hu, N.,Song, X.,Wang, Z.,Liu, X.,Wang, L.,Liu, Y. Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood 2024 0 0 0 8HOH 38211332 Crystal structure of Bcl-2 G101V in complex with sonrotoclax 2022-12-10 2024-01-17 Liu, J.,Li, S.,Wang, Q.,Feng, Y.,Xing, H.,Yang, X.,Guo, Y.,Guo, Y.,Sun, H.,Liu, X.,Yang, S.,Mei, Z.,Zhu, Y.,Cheng, Z.,Chen, S.,Xu, M.,Zhang, W.,Wan, N.,Wang, J.,Ma, Y.,Zhang, S.,Luan, X.,Xu, A.,Li, L.,Wang, H.,Yang, X.,Hong, Y.,Xue, H.,Yuan, X.,Hu, N.,Song, X.,Wang, Z.,Liu, X.,Wang, L.,Liu, Y. Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood 2024 0 0 0 8ILF 37958741 The crystal structure of dGTPalphaSe-Sp:DNApre-II:Pol X substrate ternary complex 2023-03-03 2024-01-17 Qin, T.,Hu, B.,Zhao, Q.,Wang, Y.,Wang, S.,Luo, D.,Lyu, J.,Chen, Y.,Gan, J.,Huang, Z. Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom. Int J Mol Sci 2023 24 0 0 8ILF 37958741 The crystal structure of dGTPalphaSe-Sp:DNApre-II:Pol X substrate ternary complex 2023-03-03 2024-01-17 Qin, T.,Hu, B.,Zhao, Q.,Wang, Y.,Wang, S.,Luo, D.,Lyu, J.,Chen, Y.,Gan, J.,Huang, Z. Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom. Int J Mol Sci 2023 24 0 0 8WIM 38296832 Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D307 construct) 2023-09-24 2024-01-17 Wang, X.,Jing, X.,Shi, J.,Liu, Q.,Shen, S.,Cheung, P.P.,Wu, J.,Deng, F.,Gong, P. A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res. 2024 0 0 0 8I2N The RIPK1 kinase domain in complex with QY7-2B compound 2023-01-14 2024-01-31 Gong, X.Y.,Li, Y.,Meng, H.Y.,Pan, L.F. The RIPK1 kinase domain in complex with QY7-2B compound To Be Published 0 0 0 0 8ITR 37731243 Crystal structure of lysophosphatidylcholine in complex with human serum albumin 2023-03-22 2024-01-31 Wang, Y.,Luo, Z.,Morelli, X.,Xu, P.,Jiang, L.,Shi, X.,Huang, M. Crystal structures of human serum albumin in complex with lysophosphatidylcholine. Biophys.J. 2023 122 4135 4143 8ITT 37731243 Crystal structure of lysophosphatidylcholine in complex with human serum albumin and myristate 2023-03-22 2024-01-31 Wang, Y.,Luo, Z.,Morelli, X.,Xu, P.,Jiang, L.,Shi, X.,Huang, M. Crystal structures of human serum albumin in complex with lysophosphatidylcholine. Biophys.J. 2023 122 4135 4143 8WBK 38199576 Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] 2023-09-10 2024-01-31 Dong, S.,Xuan, J.,Feng, Y.,Cui, Q. Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem. 2024 300 105635 105635 8WBL 38199576 Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] complexed with sulfate ions 2023-09-10 2024-01-31 Dong, S.,Xuan, J.,Feng, Y.,Cui, Q. Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem. 2024 300 105635 105635 8WBM 38199576 Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] mutant D193A complexed with sulfate ions 2023-09-10 2024-01-31 Dong, S.,Xuan, J.,Feng, Y.,Cui, Q. Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem. 2024 300 105635 105635 8WBN 38199576 Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] mutant D193N 2023-09-10 2024-01-31 Dong, S.,Xuan, J.,Feng, Y.,Cui, Q. Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem. 2024 300 105635 105635 8WBR 38199576 Crystal structure of cis-Epoxysuccinate Hydrolases KlCESH[L] 2023-09-10 2024-01-31 Dong, S.,Xuan, J.,Feng, Y.,Cui, Q. Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem. 2024 300 105635 105635 8WBS 38199576 Crystal structure of cis-Epoxysuccinate Hydrolases KlCESH[L]-D48N complexed with sulfate ions 2023-09-10 2024-01-31 Dong, S.,Xuan, J.,Feng, Y.,Cui, Q. Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem. 2024 300 105635 105635 8WBT 38199576 Crystal structure of cis-Epoxysuccinate Hydrolases KlCESH[L] mutant D48N complexed with L-TA 2023-09-10 2024-01-31 Dong, S.,Xuan, J.,Feng, Y.,Cui, Q. Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid. J.Biol.Chem. 2024 300 105635 105635 7YOC 38425922 Crystal structure of Fhb7 2022-08-01 2024-02-07 Yang, J.,Liang, K.,Ke, H.,Zhang, Y.,Meng, Q.,Gao, L.,Fan, J.,Li, G.,Zhou, H.,Xiao, J.,Lei, X. Enzymatic Degradation of Deoxynivalenol with the Engineered Detoxification Enzyme Fhb7. Jacs Au 2024 4 619 634 8WU2 Crystal structure of RNA-dependent RNA polymerases from Jingmen tick virus 2023-10-20 2024-02-07 Liu, Z.,Peng, Q.,Han, P.,Kuai, L.,Qi, J.,Shi, Y. Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus HLIFE 2024 2 18 31 8WU3 Crystal structure of RNA-dependent RNA polymerases from Alongshan virus 2023-10-20 2024-02-07 Liu, Z.,Peng, Q.,Han, P.,Kuai, L.,Qi, J.,Shi, Y. Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus HLIFE 2024 2 18 31 7YQO Xcc Nicotinamide Phosphoribosyltransferase 2022-08-08 2024-02-14 Xu, G.L.,Ming, Z.H. Structure of Xanthomonas campestris pv. campestris Nicotinamide Phosphoribosyltransferase: insights into bacterial NAD+ biosynthesis from the salvage pathway To Be Published 0 0 0 0 7YQP Xcc Nicotinamide Phosphoribosyltransferase 2022-08-08 2024-02-14 Xu, G.L.,Ming, Z.H. Structure of Xanthomonas campestris pv. campestris Nicotinamide Phosphoribosyltransferase: insights into bacterial NAD+ biosynthesis from the salvage pathway To Be Published 0 0 0 0 7YQQ Crystal Structure of Xcc NAMPT and its complex with NMN 2022-08-08 2024-02-14 Xu, G.L.,Ming, Z.H. Structure of Xanthomonas campestris pv. campestris Nicotinamide Phosphoribosyltransferase: insights into bacterial NAD+ biosynthesis from the salvage pathway To Be Published 0 0 0 0 7YQR Crystal Structure of Xcc NAMPT and its complex with NAM 2022-08-08 2024-02-14 Xu, G.L.,Ming, Z.H. Structure of Xanthomonas campestris pv. campestris Nicotinamide Phosphoribosyltransferase: insights into bacterial NAD+ biosynthesis from the salvage pathway To Be Published 0 0 0 0 8IVI 37336126 crystal structure of a medium-long chain fatty acyl-CoA ligase 2023-03-27 2024-02-14 Li, S.,Qu, Y. Structural study of medium-long chain fatty acyl-CoA ligase FadD8 from Mycobacterium tuberculosis. Biochem.Biophys.Res.Commun. 2023 672 65 71 8Y6B Structure of human LGI1-ADAM22 complex in space group P212121 2024-02-02 2024-02-14 Liu, H.,Xu, F. Structure of human LGI1-ADAM22 complex in space group P212121 To Be Published 0 0 0 0 8IQV 37959022 Asterias forbesii ferritin 2023-03-17 2024-02-21 Zhang, C.,Chen, X.,Liu, B.,Zang, J.,Zhang, T.,Zhao, G. Preparation and Unique Three-Dimensional Self-Assembly Property of Starfish Ferritin. Foods 2023 12 0 0 8X7X 38400047 Crystal structure of SADS-CoV fusion core 2023-11-26 2024-02-21 Wang, F.,Yang, G.,Yan, L. Crystal Structures of Fusion Cores from CCoV-HuPn-2018 and SADS-CoV. Viruses 2024 16 0 0 8IDI Crystal structure of nanobody VHH-T71 with MERS-CoV RBD 2023-02-13 2024-02-28 Idoudi, F.,Wang, R.,Tian, L.,Zhang, L.,Wang, X. Structural Definition of a Novel Nanobody Binding Site specifically targeting the MERS-CoV RBD Core-Domain with Neutralizing Capacity To Be Published 0 0 0 0 8IS2 38446858 Crystal structure of a polyketide aromatase/cyclase Abx(+)D from Actinomycetes sp. MA7150. 2023-03-20 2024-02-28 Jiang, K.,Chen, X.,Yan, X.,Li, G.,Lin, Z.,Deng, Z.,Luo, S.,Qu, X. An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin. Proc.Natl.Acad.Sci.USA 2024 121 0 0 8JEP 38460520 Crystal structure of Ociperlimab 2023-05-16 2024-02-28 Sun, J.,Zhang, X.,Xue, L.,Cheng, L.,Zhang, J.,Chen, X.,Shen, Z.,Li, K.,Wang, L.,Huang, C.,Song, J. Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure 2024 0 0 0 8JEQ 38460520 Crystal structure of Tiragolumab 2023-05-16 2024-02-28 Sun, J.,Zhang, X.,Xue, L.,Cheng, L.,Zhang, J.,Chen, X.,Shen, Z.,Li, K.,Wang, L.,Huang, C.,Song, J. Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure 2024 0 0 0 8IRK Carbon Sulfoxide lyase 2023-03-18 2024-03-06 Gong, W.M.,Wei, L.L.,Liu, L. Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE To Be Published 0 0 0 0 8IRY 38072054 Carbon Sulfoxide lyase 2023-03-20 2024-03-06 Wei, L.,Liu, L.,Gong, W. Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE. J.Biol.Chem. 2024 300 105539 105539 8IRZ 38072054 Carbon Sulfoxide lyase 2023-03-20 2024-03-06 Wei, L.,Liu, L.,Gong, W. Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtE. J.Biol.Chem. 2024 300 105539 105539 8SLM 38424107 Crystal structure of Deinococcus geothermalis PprI 2023-04-23 2024-03-13 Lu, H.,Chen, Z.,Xie, T.,Zhong, S.,Suo, S.,Song, S.,Wang, L.,Xu, H.,Tian, B.,Zhao, Y.,Zhou, R.,Hua, Y. The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA. Nat Commun 2024 15 1892 1892 8SLN 38424107 Crystal structure of Deinococcus geothermalis PprI complexed with ssDNA 2023-04-23 2024-03-13 Lu, H.,Chen, Z.,Xie, T.,Zhong, S.,Suo, S.,Song, S.,Wang, L.,Xu, H.,Tian, B.,Zhao, Y.,Zhou, R.,Hua, Y. The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA. Nat Commun 2024 15 1892 1892 8Y0G Human beta-catenin crystal structure 2024-01-22 2024-03-13 Tim, F. Crystal protein of human Beta-catenin To Be Published 0 0 0 0 8Y14 Beta-catenin Crystal Structure 2024-01-23 2024-03-13 Tim, F. Beta-catenin Crystal Structure To Be Published 0 0 0 0 8XLO 38432058 FGFR1 kinase domain with a dual-warhead covalent inhibitor CXF-007 2023-12-26 2024-03-27 Chen, X.,Li, H.,Lin, Q.,Dai, S.,Qu, L.,Guo, M.,Zhang, L.,Liao, J.,Wei, H.,Xu, G.,Jiang, L.,Chen, Y. Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4. Eur.J.Med.Chem. 2024 268 116281 116281 8XLQ 38432058 FGFR4 kinase domain with a dual-warhead covalent inhibitor CXF-007 2023-12-26 2024-03-27 Chen, X.,Li, H.,Lin, Q.,Dai, S.,Qu, L.,Guo, M.,Zhang, L.,Liao, J.,Wei, H.,Xu, G.,Jiang, L.,Chen, Y. Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4. Eur.J.Med.Chem. 2024 268 116281 116281