PDB_ID	PUBMED_CID	STRUCTURE TITLE	DEPOSITION DATE	RELEASE DATE	AUTHORS	CITATION TITLE	JOURNAL	YEAR	VOLUME	FIRST PAGE	LAST PAGE
4ZS2	26457839	Structural complex of FTO/fluorescein	2015-05-13	2015-11-04	Wang, T.,Hong, T.,Huang, Y.,Su, H.,Wu, F.,Chen, Y.,Wei, L.,Huang, W.,Hua, X.,Xia, Y.,Xu, J.,Gan, J.,Yuan, B.,Feng, Y.,Zhang, X.,Yang, C.G.,Zhou, X.	Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein	J.Am.Chem.Soc.	2015	137	13736	13739	
4ZS3	26457839	Structural complex of 5-aminofluorescein bound to the FTO protein	2015-05-13	2015-11-04	Wang, T.,Hong, T.,Huang, Y.,Su, H.,Wu, F.,Chen, Y.,Wei, L.,Huang, W.,Hua, X.,Xia, Y.,Xu, J.,Gan, J.,Yuan, B.,Feng, Y.,Zhang, X.,Yang, C.G.,Zhou, X.	Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein	J.Am.Chem.Soc.	2015	137	13736	13739	
5CA0	26462166	Crystal structure of T2R-TTL-Lexibulin complex	2015-06-29	2015-11-04	Wang, Y.,Zhang, H.,Gigant, B.,Yu, Y.,Wu, Y.,Chen, X.,Lai, Q.,Yang, Z.,Chen, Q.,Yang, J.	Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.	Febs J.	2016	283	102	111	
5CA1	26462166	Crystal structure of T2R-TTL-Nocodazole complex	2015-06-29	2015-11-04	Wang, Y.,Zhang, H.,Gigant, B.,Yu, Y.,Wu, Y.,Chen, X.,Lai, Q.,Yang, Z.,Chen, Q.,Yang, J.	Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.	Febs J.	2016	283	102	111	
5CB4	26462166	Crystal structure of T2R-TTL-Tivantinib complex	2015-06-30	2015-11-04	Wang, Y.,Zhang, H.,Gigant, B.,Yu, Y.,Wu, Y.,Chen, X.,Lai, Q.,Yang, Z.,Chen, Q.,Yang, J.	Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.	Febs J.	2016	283	102	111	
5CMS	26481419	Structural Insights into the Mechanism of Escherichia coli Ymdb	2015-07-17	2015-11-04	Zhang, W.,Wang, C.,Song, Y.,Shao, C.,Zhang, X.,Zang, J.	Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase	J.Struct.Biol.	2015	192	478	486	
5D9Y	26524525	Crystal structure of TET2-5fC complex	2015-08-19	2015-11-04	Hu, L.,Lu, J.,Cheng, J.,Rao, Q.,Li, Z.,Hou, H.,Lou, Z.,Zhang, L.,Li, W.,Gong, W.,Liu, M.,Sun, C.,Yin, X.,Li, J.,Tan, X.,Wang, P.,Wang, Y.,Fang, D.,Cui, Q.,Yang, P.,He, C.,Jiang, H.,Luo, C.,Xu, Y.	Structural insight into substrate preference for TET-mediated oxidation.	Nature	2015	527	118	122	
5DX4	26731490	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand	2015-09-23	2016-01-13	Xue, X.,Zhang, Y.,Liu, Z.,Song, M.,Xing, Y.,Xiang, Q.,Wang, Z.,Tu, Z.,Zhou, Y.,Ding, K.,Xu, Y.	Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation	J.Med.Chem.	2016	59	1565	1579	
5F1B	26771495	Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1	2015-11-30	2016-01-20	Wang, H.,Shi, Y.,Song, J.,Qi, J.,Lu, G.,Yan, J.,Gao, G.F.	Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.	Cell	2016	164	258	268	
4Y5W	27803324	Transcription factor-DNA complex	2015-02-12	2016-02-17	Li, J.,Rodriguez, J.P.,Niu, F.,Pu, M.,Wang, J.,Hung, L.W.,Shao, Q.,Zhu, Y.,Ding, W.,Liu, Y.,Da, Y.,Yao, Z.,Yang, J.,Zhao, Y.,Wei, G.H.,Cheng, G.,Liu, Z.J.,Ouyang, S.	Structural basis for DNA recognition by STAT6	Proc.Natl.Acad.Sci.USA	2016	113	13015	13020	
5F5E	26886794	The Crystal Structure of MLL1 SET domain with N3816I/Q3867L mutation	2015-12-04	2016-02-24	Li, Y.,Han, J.,Zhang, Y.,Cao, F.,Liu, Z.,Li, S.,Wu, J.,Hu, C.,Wang, Y.,Shuai, J.,Chen, J.,Cao, L.,Li, D.,Shi, P.,Tian, C.,Zhang, J.,Dou, Y.,Li, G.,Chen, Y.,Lei, M.	Structural basis for activity regulation of MLL family methyltransferases.	Nature	2016	530	447	452	
5HV1	27001859	Rifampin phosphotransferase in complex with AMPPNP and rifampin from Listeria monocytogenes	2016-01-28	2016-03-30	Qi, X.,Lin, W.,Ma, M.,Wang, C.,He, Y.,He, N.,Gao, J.,Zhou, H.,Xiao, Y.,Wang, Y.,Zhang, P.	Structural basis of rifampin inactivation by rifampin phosphotransferase	Proc.Natl.Acad.Sci.USA	2016	113	3803	3808	
5HV3	27001859	Rifampin phosphotransferase G527Y mutant in complex with AMPPNP from Listeria monocytogenes	2016-01-28	2016-03-30	Qi, X.,Lin, W.,Ma, M.,Wang, C.,He, Y.,He, N.,Gao, J.,Zhou, H.,Xiao, Y.,Wang, Y.,Zhang, P.	Structural basis of rifampin inactivation by rifampin phosphotransferase	Proc.Natl.Acad.Sci.USA	2016	113	3803	3808	
5HV6	27001859	The ATP binding domain of rifampin phosphotransferase from Listeria monocytogenes	2016-01-28	2016-03-30	Qi, X.,Lin, W.,Ma, M.,Wang, C.,He, Y.,He, N.,Gao, J.,Zhou, H.,Xiao, Y.,Wang, Y.,Zhang, P.	Structural basis of rifampin inactivation by rifampin phosphotransferase	Proc.Natl.Acad.Sci.USA	2016	113	3803	3808	
5CH8		Crystal structure of MDLA N225Q mutant form Penicillium cyclopium	2015-07-10	2016-04-20	Tang, Q.,Popowicz, G.M.,Wang, X.,Liu, J.,Pavlidis, I.V.,Wang, Y.	Lipase-Driven Epoxidation Is A Two-Stage Synergistic Process	ChemistrySelect	2016	4	836	839	
5H93	27071000	Crystal structure of Geobacter metallireducens SMUG1	2015-12-25	2016-04-27	Zhang, Z.,Shen, J.,Yang, Y.,Li, J.,Cao, W.,Xie, W.	Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1	Acs Chem.Biol.	2016	11	1729	1736	
5I9D	27088764	Crystal structure of designed pentatricopeptide repeat protein dPPR-U8A2 in complex with its target RNA U8A2	2016-02-20	2016-04-27	Shen, C.,Zhang, D.,Guan, Z.,Liu, Y.,Yang, Z.,Yang, Y.,Wang, X.,Wang, Q.,Zhang, Q.,Fan, S.,Zou, T.,Yin, P.	Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins.	Nat Commun	2016	7	11285	11285	
5I9G	27088764	Crystal structure of designed pentatricopeptide repeat protein dPPR-U8C2 in complex with its target RNA U8C2	2016-02-20	2016-04-27	Shen, C.,Zhang, D.,Guan, Z.,Liu, Y.,Yang, Z.,Yang, Y.,Wang, X.,Wang, Q.,Zhang, Q.,Fan, S.,Zou, T.,Yin, P.	Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins.	Nat Commun	2016	7	11285	11285	
5I9H	27088764	Crystal structure of designed pentatricopeptide repeat protein dPPR-U8G2 in complex with its target RNA U8G2	2016-02-20	2016-04-27	Shen, C.,Zhang, D.,Guan, Z.,Liu, Y.,Yang, Z.,Yang, Y.,Wang, X.,Wang, Q.,Zhang, Q.,Fan, S.,Zou, T.,Yin, P.	Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins.	Nat Commun	2016	7	11285	11285	
5ID6	27096363	Structure of Cpf1/RNA Complex	2016-02-24	2016-04-27	Dong, D.,Ren, K.,Qiu, X.,Zheng, J.,Guo, M.,Guan, X.,Liu, H.,Li, N.,Zhang, B.,Yang, D.,Ma, C.,Wang, S.,Wu, D.,Ma, Y.,Fan, S.,Wang, J.,Gao, N.,Huang, Z.	The crystal structure of Cpf1 in complex with CRISPR RNA	Nature	2016	532	522	526	
5FNV	27357539	a new complex structure of tubulin with an alpha-beta unsaturated lactone	2015-11-16	2016-05-18	Yang, J.,Wang, Y.,Wang, T.,Jiang, J.,Botting, C.H.,Liu, H.,Chen, Q.,Yang, J.,Naismith, J.H.,Zhu, X.,Chen, L.	Pironetin Reacts Covalently with Cysteine-316 of Alpha-Tubulin to Destabilize Microtubule.	Nat.Commun.	2016	7	12103	0	
5JQG	27357539	An apo tubulin-RB-TTL complex structure used for side-by-side comparison	2016-05-04	2016-05-18	Yang, J.,Wang, Y.X.,Wang, T.,Jiang, J.,Botting, C.H.,Liu, H.,Chen, Q.,Yang, J.,Naismith, J.H.,Zhu, X.,Chen, L.	Pironetin reacts covalently with cysteine-316 of alpha-tubulin to destabilize microtubule	Nat Commun	2016	7	12103	12103	
5IL1	27281194	Crystal structure of SAM-bound METTL3-METTL14 complex	2016-03-04	2016-05-25	Wang, X.,Feng, J.,Xue, Y.,Guan, Z.,Zhang, D.,Liu, Z.,Gong, Z.,Wang, Q.,Huang, J.,Tang, C.,Zou, T.,Yin, P.	Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex	Nature	2016	534	575	578	
5IL2	27281194	Crystal structure of SAH-bound METTL3-METTL14 complex	2016-03-04	2016-05-25	Wang, X.,Feng, J.,Xue, Y.,Guan, Z.,Zhang, D.,Liu, Z.,Gong, Z.,Wang, Q.,Huang, J.,Tang, C.,Zou, T.,Yin, P.	Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex	Nature	2016	534	575	578	
5CIO	27231346	Crystal structure of PqqF	2015-07-13	2016-06-08	Wei, Q.,Ran, T.,Ma, C.,He, J.,Xu, D.,Wang, W.	Crystal Structure and Function of PqqF Protein in the Pyrroloquinoline Quinone Biosynthetic Pathway	J.Biol.Chem.	2016	291	15575	15587	
5B5R	27281216	Crystal structure of GSDMA3	2016-05-14	2016-06-15	Ding, J.,Wang, K.,Liu, W.,She, Y.,Sun, Q.,Shi, J.,Sun, H.,Wang, D.C.,Shao, F.	Pore-forming activity and structural autoinhibition of the gasdermin family.	Nature	2016	535	111	116	
5I8P	27078579	Crystal structure of LP_PLA2 in complex with novel inhibitor	2016-02-19	2016-06-15	Liu, Q.F.,Chen, X.D.,Chen, W.Y.,Yuan, X.J.,Su, H.X.,Shen, J.H.,Xu, Y.C.	Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors	J.Med.Chem.	2016	59	5115	5120	
5ITR	27354518	Crystal Structure of Human NEIL1(P2G) bound to duplex DNA containing THF	2016-03-17	2016-07-06	Zhu, C.,Lu, L.,Zhang, J.,Yue, Z.,Song, J.,Zong, S.,Liu, M.,Stovicek, O.,Gao, Y.Q.,Yi, C.	Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair	Proc.Natl.Acad.Sci.USA	2016	113	7792	7797	
5ITX	27354518	Crystal Structure of Human NEIL1(P2G R242K) bound to duplex DNA containing Thymine Glycol	2016-03-17	2016-07-06	Zhu, C.,Lu, L.,Zhang, J.,Yue, Z.,Song, J.,Zong, S.,Liu, M.,Stovicek, O.,Gao, Y.Q.,Yi, C.	Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair	Proc.Natl.Acad.Sci.USA	2016	113	7792	7797	
5CF2		Crystal Structure of the I80Y/L114V/I116V mutant of LEH	2015-07-08	2016-07-13	Wu, L.,Sun, Z.T.,Reetz, M.T.,Zhou, J.H.	Crystal Structure of the I80Y/L114V/I116V mutant of LEH	To Be Published	0	0	0	0	
5GJB	27430951	Zika virus NS3 helicase in complex with ssRNA	2016-06-28	2016-07-20	Tian, H.L.,Ji, X.Y.,Yang, X.Y.,Zhang, Z.X.,Lu, Z.K.,Yang, K.L.,Chen, C.,Zhao, Q.,Chi, H.,Mu, Z.Y.,Xie, W.,Wang, Z.F.,Lou, H.Q.,Yang, H.T.,Rao, Z.H.	Structural basis of Zika virus helicase in recognizing its substrates	Protein Cell	2016	7	562	570	
5GJC	27430951	Zika virus NS3 helicase in complex with ATP	2016-06-28	2016-07-20	Tian, H.L.,Ji, X.Y.,Yang, X.Y.,Zhang, Z.X.,Lu, Z.K.,Yang, K.L.,Chen, C.,Zhao, Q.,Chi, H.,Mu, Z.Y.,Xie, W.,Wang, Z.F.,Lou, H.Q.,Yang, H.T.,Rao, Z.H.	Structural basis of Zika virus helicase in recognizing its substrates	Protein Cell	2016	7	562	570	
5HIN		Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L compound	2016-01-12	2016-07-20	Huang, J.,Wu, D.,Lu, Q.,Yao, X.	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L at 1.60 A resolution	To Be Published	0	0	0	0	
5HQE		Crystal structure of human dihydroorotate dehydrogenase (DHODH) with compound 18T	2016-01-21	2016-07-27	Huang, J.,Wu, D.,Lu, Q.	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18T at 1.62 A resolution	To Be Published	0	0	0	0	
5B85	27476534	X-ray structure of ferric F138Y sperm whale myoglobin	2016-06-12	2016-08-10	Liao, F.,Yuan, H.,Du, K.J.,You, Y.,Gao, S.Q.,Wen, G.B.,Lin, Y.W.,Tan, X.	Distinct roles of a tyrosine-associated hydrogen-bond network in fine-tuning the structure and function of heme proteins: two cases designed for myoglobin	Mol Biosyst	2016	12	3139	3145	
5DDU	26714051	Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with PMP	2015-08-25	2016-08-10	Zhu, Y.,Xu, J.,Mei, X.,Feng, Z.,Zhang, L.,Zhang, Q.,Zhang, G.,Zhu, W.,Liu, J.,Zhang, C.	Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis	Acs Chem.Biol.	2016	11	943	952	
5DDW	26714051	Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with the PMP external aldimine adduct with Caerulomycin M	2015-08-25	2016-08-10	Zhu, Y.,Xu, J.,Mei, X.,Feng, Z.,Zhang, L.,Zhang, Q.,Zhang, G.,Zhu, W.,Liu, J.,Zhang, C.	Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis	Acs Chem.Biol.	2016	11	943	952	
5D74		The crystal structure of Ly7917	2015-08-13	2016-08-17	Wu, L.,Ji, W.H.,Sun, J.H.,Zhou, J.H.	The crystal structure of Ly7917	To Be Published	0	0	0	0	
5I5N	27411929	Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Acidic pH.	2016-02-15	2016-08-17	Yang, M.,Feng, F.,Liu, Y.,Wang, H.,Yang, Z.,Hou, W.,Liang, H.	pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating	J.Gen.Virol.	2016	97	2149	2156	
5I5O	27411929	Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Neutral pH.	2016-02-15	2016-08-17	Yang, M.,Feng, F.,Liu, Y.,Wang, H.,Yang, Z.,Hou, W.,Liang, H.	pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating	J.Gen.Virol.	2016	97	2149	2156	
5IX2	27528681	Crystal structure of mouse Morc3 ATPase-CW cassette in complex with AMPPNP and unmodified H3 peptide	2016-03-23	2016-08-17	Li, S.,Yen, L.,Pastor, W.A.,Johnston, J.B.,Du, J.,Shew, C.J.,Liu, W.,Ho, J.,Stender, B.,Clark, A.T.,Burlingame, A.L.,Daxinger, L.,Patel, D.J.,Jacobsen, S.E.	Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin	Proc.Natl.Acad.Sci.USA	2016	113	0	0	
5B84	27476534	X-ray crystal structure of met I107Y sperm whale myoglobin	2016-06-12	2016-08-24	Liao, F.,Yuan, H.,Du, K.J.,You, Y.,Gao, S.Q.,Wen, G.B.,Lin, Y.W.,Tan, X.	Distinct roles of a tyrosine-associated hydrogen-bond network in fine-tuning the structure and function of heme proteins: two cases designed for myoglobin	Mol Biosyst	2016	12	3139	3145	
5JJO	27397502	The crystal structure of immunity protein PA5088 from Pseudomonas aeruginosa	2016-04-24	2016-08-31	Yang, X.Y.,Li, Z.Q.,She, Z.,Geng, Z.,Xu, J.H.,Gao, Z.Q.,Dong, Y.H.	Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins	Febs Lett.	2016	590	2787	2796	
5JKP	27397502	Crystal structure of immunity protein Pa5087 from Pseudomonas aeruginosa	2016-04-26	2016-08-31	Yang, X.Y.,Li, Z.Q.,She, Z.,Geng, Z.,Xu, J.H.,Gao, Z.Q.,Dong, Y.H.	Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins	Febs Lett.	2016	590	2787	2796	
5HSJ	27292129	Structure of tyrosine decarboxylase complex with PLP at 1.9 Angstroms resolution	2016-01-25	2016-09-14	Zhu, H.X.,Xu, G.C.,Zhang, K.,Kong, X.D.,Han, R.Z.,Zhou, J.H.,Ni, Y.	Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding	Sci Rep	2016	6	27779	27779	
5ISY	27561816	Crystal structure of Nudix family protein with NAD	2016-03-15	2016-09-14	Zhang, D.,Liu, Y.,Wang, Q.,Guan, Z.,Wang, J.,Liu, J.,Zou, T.,Yin, P.	Structural basis of prokaryotic NAD-RNA decapping by NudC	Cell Res.	2016	26	1062	1066	
5GNF	27585537	Crystal structure of anti-CRISPR protein AcrF3	2016-07-20	2016-09-21	Wang, J.,Ma, J.,Cheng, Z.,Meng, X.,You, L.,Wang, M.,Zhang, X.,Wang, Y.	A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses	Cell Res.	2016	26	1165	1168	
5GS9	27648300	Crystal structure of CASTOR1-arginine	2016-08-15	2016-09-28	Xia, J.,Wang, R.,Zhang, T.,Ding, J.	Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.	Cell Discov	2016	2	16035	16035	
5J5C	27436755	Crystal structure of ARL1-GTP and DCB domain of BIG1 complex	2016-04-02	2016-09-28	Wang, R.,Wang, Z.,Wang, K.,Zhang, T.,Ding, J.	Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1	J Mol Cell Biol	2016	0	0	0	
5HJK	27629654	Crystal Structure of Pyrococcus abyssi Trm5a complexed with SAH	2016-01-13	2016-10-12	Wang, C.,Jia, Q.,Chen, R.,Wei, Y.,Li, J.,Ma, J.,Xie, W.	Crystal structures of the bifunctional tRNA methyltransferase Trm5a	Sci Rep	2016	6	33553	33553	
5HQP	27642162	Crystal structure of the ERp44-peroxiredoxin 4 complex	2016-01-22	2016-10-12	Yang, K.,Li, D.F.,Wang, X.,Liang, J.,Sitia, R.,Wang, C.C.,Wang, X.	Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.	Structure	2016	24	1755	1765	
5EJD	27748753	The crystal structure of holo T3CT	2015-11-01	2016-10-19	Zhang, J.,Liu, N.,Cacho, R.A.,Gong, Z.,Liu, Z.,Qin, W.,Tang, C.,Tang, Y.,Zhou, J.	Structural basis of nonribosomal peptide macrocyclization in fungi	Nat.Chem.Biol.	2016	12	1001	1003	
5H0N	27795416	Crystal structure of HIV-1 fusion inhibitor MT-WQ-IDL bound to gp41 NHR	2016-10-06	2016-11-02	Su, S.,Zhu, Y.,Ye, S.,Qi, Q.,Xia, S.,Ma, Z.,Yu, F.,Wang, Q.,Zhang, R.,Jiang, S.,Lu, L.	Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors	J. Virol.	2017	91	0	0	
5KU3	27682507	BRD4 bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone)	2016-07-12	2016-11-02	Crawford, T.D.,Romero, F.A.,Lai, K.W.,Tsui, V.,Taylor, A.M.,de Leon Boenig, G.,Noland, C.L.,Murray, J.,Ly, J.,Choo, E.F.,Hunsaker, T.L.,Chan, E.W.,Merchant, M.,Kharbanda, S.,Gascoigne, K.E.,Kaufman, S.,Beresini, M.H.,Liao, J.,Liu, W.,Chen, K.X.,Chen, Z.,Conery, A.R.,Cote, A.,Jayaram, H.,Jiang, Y.,Kiefer, J.R.,Kleinheinz, T.,Li, Y.,Maher, J.,Pardo, E.,Poy, F.,Spillane, K.L.,Wang, F.,Wang, J.,Wei, X.,Xu, Z.,Xu, Z.,Yen, I.,Zawadzke, L.,Zhu, X.,Bellon, S.,Cummings, R.,Cochran, A.G.,Albrecht, B.K.,Magnuson, S.	Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.	J. Med. Chem.	2016	59	10549	10563	
5JWH	27915293	Apo structure	2016-05-12	2016-11-09	Cao, X.,Li, Y.,Jin, X.,Li, Y.,Guo, F.,Jin, T.	Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design.	Nucleic Acids Res.	2016	44	10505	10514	
5K8T	27915293	Crystal structure of ZIKV NS3 helicase in complex with GTP-gammar S and an magnesium ion	2016-05-31	2016-11-09	Cao, X.,Li, Y.,Jin, X.,Li, Y.,Guo, F.,Jin, T.	Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design.	Nucleic Acids Res.	2016	44	10505	10514	
5K8U	27915293	Crystal structure of ZIKV NS3 helicase in complex with ADP and Mn2+	2016-05-31	2016-11-09	Cao, X.,Li, Y.,Jin, X.,Li, Y.,Guo, F.,Jin, T.	Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design.	Nucleic Acids Res.	2016	44	10505	10514	
5GJT	27910950	Crystal structure of H1 hemagglutinin from A/Washington/05/2011 in complex with a neutralizing antibody 3E1	2016-07-01	2016-12-07	Wang, W.,Sun, X.,Li, Y.,Su, J.,Ling, Z.,Zhang, T.,Wang, F.,Zhang, H.,Chen, H.,Ding, J.,Sun, B.	Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses	Nat Commun	2016	7	13577	13577	
5GOZ	27866982	Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH	2016-07-30	2016-12-07	Zhang, C.,Feng, T.,Cheng, J.,Li, Y.,Yin, X.,Zeng, W.,Jin, X.,Li, Y.,Guo, F.,Jin, T.	Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design	Biochem. Biophys. Res. Commun.	2017	492	624	630	
5GP1	27866982	Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH	2016-07-30	2016-12-07	Zhang, C.,Feng, T.,Cheng, J.,Li, Y.,Yin, X.,Zeng, W.,Jin, X.,Li, Y.,Guo, F.,Jin, T.	Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design	Biochem. Biophys. Res. Commun.	2017	492	624	630	
5GZA	27879205	protein O-mannose kinase	2016-09-27	2016-12-07	Zhu, Q.,Venzke, D.,Walimbe, A.S.,Anderson, M.E.,Fu, Q.,Kinch, L.N.,Wang, W.,Chen, X.,Grishin, N.V.,Huang, N.,Yu, L.,Dixon, J.E.,Campbell, K.P.,Xiao, J.	Structure of protein O-mannose kinase reveals a unique active site architecture	Elife	2016	5	0	0	
5GQR	27449136	Crystal structure of PXY-CLE41-SERK2	2016-08-08	2016-12-14	Zhang, H.Q.,Lin, X.Y.,Han, Z.F.,Wang, J.,Qu, L.J.,Chai, J.J.	SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development	Mol Plant	2016	9	1406	1414	
5JVV	27956553	Crystal structure and characterization an elongating GH family 16 beta-1,3-glucosyltransferase	2016-05-11	2016-12-14	Qin, Z.,Yang, S.,Zhao, L.,You, X.,Yan, Q.,Jiang, Z.	Catalytic Mechanism of a Novel Glycoside Hydrolase Family 16 ""Elongating"" beta-Transglycosylase	J. Biol. Chem.	2017	292	1666	1678	
5GZN	27974667	Structure of neutralizing antibody bound to Zika envelope protein	2016-09-29	2016-12-28	Wang, Q.,Yang, H.,Liu, X.,Dai, L.,Ma, T.,Qi, J.,Wong, G.,Peng, R.,Liu, S.,Li, J.,Li, S.,Song, J.,Liu, J.,He, J.,Yuan, H.,Xiong, Y.,Liao, Y.,Li, J.,Yang, J.,Tong, Z.,Griffin, B.D.,Bi, Y.,Liang, M.,Xu, X.,Qin, C.,Cheng, G.,Zhang, X.,Wang, P.,Qiu, X.,Kobinger, G.,Shi, Y.,Yan, J.,Gao, G.F.	Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus	Sci Transl Med	2016	8	0	0	
5HAB		Crystal structure of mpy-RNase J (mutant H84A), an archaeal RNase J from Methanolobus psychrophilus R15, complex with RNA	2015-12-30	2017-01-04	Zheng, X.,Feng, N.,Li, D.F.,Li, J.,Dong, X.Z.	Molecular insights into catalysis and processive exonucleolytic mechanisms of prokaryotic RNase J revealing striking parallels with that of eukaryotic Xrn1	To Be Published	0	0	0	0	
5EZY	28585532	Crystal structure of T2R-TTL-taccalonolide AJ complex	2015-11-27	2017-01-11	Wang, Y.,Yu, Y.,Li, G.B.,Li, S.A.,Wu, C.,Gigant, B.,Qin, W.,Chen, H.,Wu, Y.,Chen, Q.,Yang, J.	Mechanism of microtubule stabilization by taccalonolide AJ	Nat Commun	2017	8	15787	15787	
5HDK		Crystal structure of heat shock factor 2-DBD	2016-01-05	2017-01-11	Feng, H.,Liu, W.,Wang, D.C.	HSF1-DBD crystal structure	To Be Published	0	0	0	0	
5HDN		Crystal structure of heat shock factor1-DBD complex with ds-DNA and TtT	2016-01-05	2017-01-11	Feng, H.,Liu, W.,Wang, D.C.	HSF1-DBD crystal structure	To Be Published	0	0	0	0	
5IMK	27889311	Nanobody targeting human Vsig4 in Spacegroup C2	2016-03-06	2017-01-11	Wen, Y.,Ouyang, Z.,Schoonooghe, S.,Luo, S.,De Baetselier, P.,Lu, W.,Muyldermans, S.,Raes, G.,Zheng, F.	Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity	Immunobiology	2017	222	807	813	
5IML	27889311	Nanobody targeting human Vsig4 in Spacegroup P212121	2016-03-06	2017-01-11	Wen, Y.,Ouyang, Z.,Schoonooghe, S.,Luo, S.,De Baetselier, P.,Lu, W.,Muyldermans, S.,Raes, G.,Zheng, F.	Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity	Immunobiology	2017	222	807	813	
5IMM	27889311	Nanobody targeting mouse Vsig4 in Spacegroup P212121	2016-03-06	2017-01-11	Wen, Y.,Ouyang, Z.,Schoonooghe, S.,Luo, S.,De Baetselier, P.,Lu, W.,Muyldermans, S.,Raes, G.,Zheng, F.	Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity	Immunobiology	2017	222	807	813	
5IMO	27889311	Nanobody targeting mouse Vsig4 in Spacegroup P3221	2016-03-06	2017-01-11	Wen, Y.,Ouyang, Z.,Schoonooghe, S.,Luo, S.,De Baetselier, P.,Lu, W.,Muyldermans, S.,Raes, G.,Zheng, F.	Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity	Immunobiology	2017	222	807	813	
5GSN	27997715	Tmm in complex with methimazole	2016-08-16	2017-01-18	Li, C.Y.,Chen, X.L.,Zhang, D.,Wang, P.,Sheng, Q.,Peng, M.,Xie, B.B.,Qin, Q.L.,Li, P.Y.,Zhang, X.Y.,Su, H.N.,Song, X.Y.,Shi, M.,Zhou, B.C.,Xun, L.Y.,Chen, Y.,Zhang, Y.Z.	Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide	Mol. Microbiol.	2017	103	992	1003	
5H5D	27990635	The crystal structure of the yeast arginine methyltransferase SFM1 complexed with MTA	2016-11-05	2017-01-18	Wang, C.,Zeng, J.,Xie, W.	A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1.	FEBS Lett.	2017	591	433	441	
5H5F	27990635	The crystal structure of the yeast arginine methyltransferase SFM1 complexed with SAM	2016-11-05	2017-01-18	Wang, C.,Zeng, J.,Xie, W.	A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1.	FEBS Lett.	2017	591	433	441	
5HC3	27328716	The structure of esterase Est22	2016-01-04	2017-01-18	Huang, J.,Huo, Y.Y.,Ji, R.,Kuang, S.,Ji, C.,Xu, X.W.,Li, J.	Structural insights of a hormone sensitive lipase homologue Est22.	Sci Rep	2016	6	28550	28550	
5HC4	27328716	Structure of esterase Est22	2016-01-04	2017-01-18	Huang, J.,Huo, Y.Y.,Ji, R.,Kuang, S.,Ji, C.,Xu, X.W.,Li, J.	Structural insights of a hormone sensitive lipase homologue Est22.	Sci Rep	2016	6	28550	28550	
5HRI		The crystal structure of AsfvPolX:DNA1 binary complex	2016-01-23	2017-01-18	Chen, Y.Q.,Zhang, J.,Gan, J.H.	The crystal structure of AsfvPolX: 1nt-gap(P) DNA1: dGTP ternary complex.	To Be Published	0	0	0	0	
5HRL		The crystal structure of AsfvPolX: 1nt-gap(P) DNA2: dGTP ternary complex.	2016-01-23	2017-01-18	Chen, Y.Q.,Zhang, J.,Gan, J.H.	The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1	To Be Published	0	0	0	0	
5IPY	27997715	Crystal structure of WT RnTmm	2016-03-10	2017-01-18	Li, C.Y.,Chen, X.L.,Zhang, D.,Wang, P.,Sheng, Q.,Peng, M.,Xie, B.B.,Qin, Q.L.,Li, P.Y.,Zhang, X.Y.,Su, H.N.,Song, X.Y.,Shi, M.,Zhou, B.C.,Xun, L.Y.,Chen, Y.,Zhang, Y.Z.	Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide	Mol. Microbiol.	2017	103	992	1003	
5IQ1	27997715	Crystal structure of RnTmm mutant Y207S	2016-03-10	2017-01-18	Li, C.Y.,Chen, X.L.,Zhang, D.,Wang, P.,Sheng, Q.,Peng, M.,Xie, B.B.,Qin, Q.L.,Li, P.Y.,Zhang, X.Y.,Su, H.N.,Song, X.Y.,Shi, M.,Zhou, B.C.,Xun, L.Y.,Chen, Y.,Zhang, Y.Z.	Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide	Mol. Microbiol.	2017	103	992	1003	
5IQ4	27997715	Crystal structure of RnTmm mutant Y207S soaking	2016-03-10	2017-01-18	Li, C.Y.,Chen, X.L.,Zhang, D.,Wang, P.,Sheng, Q.,Peng, M.,Xie, B.B.,Qin, Q.L.,Li, P.Y.,Zhang, X.Y.,Su, H.N.,Song, X.Y.,Shi, M.,Zhou, B.C.,Xun, L.Y.,Chen, Y.,Zhang, Y.Z.	Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide	Mol. Microbiol.	2017	103	992	1003	
5HNV	29858276	Crystal structure of PpkA	2016-01-19	2017-01-25	Li, P.P.,Xu, D.Q.,Ma, T.Q.,Wang, D.Y.,Li, W.D.,He, J.H.,Ran, T.T.,Wang, W.W.	Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism.	Biochem.J.	2018	475	2209	2224	
5WQE	27989439	Crystal structure of Alicyclobacillus acidoterrestris C2c1 in complex with single-guide RNA at 3.1 Angstrom resolution	2016-11-26	2017-01-25	Liu, L.,Chen, P.,Wang, M.,Li, X.,Wang, J.,Yin, M.,Wang, Y.	C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism	Mol. Cell	2017	65	310	322	
5HTI		Crystal structure of c-Met kinase domain in complex with LXM108	2016-01-26	2017-02-01	Xu, Y.C.,Long, Y.	Crystal structure of c-Met kinase domain in complex with LXM108	to be published	0	0	0	0	
5HU4	26826492	Cystal structure of listeria monocytogenes sortase A	2016-01-27	2017-02-01	Li, H.,Chen, Y.,Zhang, B.,Niu, X.,Song, M.,Luo, Z.,Lu, G.,Liu, B.,Zhao, X.,Wang, J.,Deng, X.	Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection.	Biochem. Pharmacol.	2016	106	19	29	
5HYC	29500373	Structure based function annotation of a hypothetical protein MGG_01005 related to the development of rice blast fungus	2016-02-01	2017-02-01	Li, G.,Huang, J.,Yang, J.,He, D.,Wang, C.,Qi, X.,Taylor, I.A.,Liu, J.,Peng, Y.L.	Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3.	Sci Rep	2018	8	3952	3952	
5WSP	27998930	Crystal structure of DNA3 duplex	2016-12-08	2017-02-08	Liu, H.H.,Cai, C.,Haruehanroengra, P.,Yao, Q.Q.,Chen, Y.Q.,Yang, C.,Luo, Q.,Wu, B.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H.	Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex	Nucleic Acids Res.	2017	45	2910	2918	
5WSQ	27998930	Crystal structure of C-Hg-T pair containing DNA duplex	2016-12-08	2017-02-08	Liu, H.H.,Cai, C.,Haruehanroengra, P.,Yao, Q.Q.,Chen, Y.Q.,Yang, C.,Luo, Q.,Wu, B.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H.	Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex	Nucleic Acids Res.	2017	45	2910	2918	
5WSR	27998930	Crystal structure of T-Hg-T pair containing DNA duplex	2016-12-08	2017-02-08	Liu, H.H.,Cai, C.,Haruehanroengra, P.,Yao, Q.Q.,Chen, Y.Q.,Yang, C.,Luo, Q.,Wu, B.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H.	Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex	Nucleic Acids Res.	2017	45	2910	2918	
5WSS	27998930	Crystal structure of T-Hg-T pair containing DNA duplex in the presence Ba2+	2016-12-08	2017-02-08	Liu, H.H.,Cai, C.,Haruehanroengra, P.,Yao, Q.Q.,Chen, Y.Q.,Yang, C.,Luo, Q.,Wu, B.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H.	Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex	Nucleic Acids Res.	2017	45	2910	2918	
5WTJ	28086085	Crystal structure of an endonuclease	2016-12-13	2017-02-08	Liu, L.,Li, X.,Wang, J.,Wang, M.,Chen, P.,Yin, M.,Li, J.,Sheng, G.,Wang, Y.	Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities	Cell	2017	168	121	0	
5GRE	28098230	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), citrate and ADP	2016-08-11	2017-02-15	Ma, T.,Peng, Y.,Huang, W.,Ding, J.	Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.	Sci Rep	2017	7	40921	40921	
5GRF	28098230	Crystal structure of the alpha gamma mutant (gamma-K151A) of human IDH3 in complex with Mg(2+), citrate and ADP	2016-08-11	2017-02-15	Ma, T.,Peng, Y.,Huang, W.,Ding, J.	Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.	Sci Rep	2017	7	40921	40921	
5GRH	28098230	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+)	2016-08-11	2017-02-15	Ma, T.,Peng, Y.,Huang, W.,Ding, J.	Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.	Sci Rep	2017	7	40921	40921	
5GRI	28098230	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) and citrate	2016-08-11	2017-02-15	Ma, T.,Peng, Y.,Huang, W.,Ding, J.	Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.	Sci Rep	2017	7	40921	40921	
5GRL	28098230	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+), isocitrate and ADP	2016-08-11	2017-02-15	Ma, T.,Peng, Y.,Huang, W.,Ding, J.	Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.	Sci Rep	2017	7	40921	40921	
5GOU	27885765	Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign	2016-07-29	2017-02-22	Zhang, S.,Zang, J.,Wang, W.,Chen, H.,Zhang, X.,Wang, F.,Wang, H.,Zhao, G.	Conversion of the Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues.	Angew. Chem. Int. Ed. Engl.	2016	55	16064	16070	
5H1T	28207202	Complex structure of TRIM24 PHD-bromodomain and inhibitor 1	2016-10-11	2017-02-22	Liu, J.,Li, F.,Bao, H.,Jiang, Y.,Zhang, S.,Ma, R.,Gao, J.,Wu, J.,Ruan, K.	The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network	FEBS J.	2017	284	1082	1095	
5H1U	28207202	Complex structure of TRIM24 PHD-bromodomain and inhibitor 2	2016-10-11	2017-02-22	Liu, J.,Li, F.,Bao, H.,Jiang, Y.,Zhang, S.,Ma, R.,Gao, J.,Wu, J.,Ruan, K.	The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network	FEBS J.	2017	284	1082	1095	
5H1V	28207202	Complex structure of TRIM24 PHD-bromodomain and inhibitor 6	2016-10-11	2017-02-22	Liu, J.,Li, F.,Bao, H.,Jiang, Y.,Zhang, S.,Ma, R.,Gao, J.,Wu, J.,Ruan, K.	The polar warhead of a TRIM24 bromodomain inhibitor rearranges a water-mediated interaction network	FEBS J.	2017	284	1082	1095	
5H2Z		Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with 7GF	2016-10-19	2017-03-01	Huang, J.,Wu, D.	Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with 7GF	To Be Published	0	0	0	0	
5IN1	27638467	Crystal Structure of the MRG701 chromodomain	2016-03-07	2017-03-01	Liu, Y.,Wu, H.,Yu, Y.,Huang, Y.	Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants	Protein Cell	2016	7	792	803	
5LUS	28228481	Structures of DHBN domain of Pelecanus crispus BLM helicase	2016-09-09	2017-03-01	Shi, J.,Chen, W.F.,Zhang, B.,Fan, S.H.,Ai, X.,Liu, N.N.,Rety, S.,Xi, X.G.	A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.	J. Biol. Chem.	2017	292	5909	5920	
5LUT	28228481	Structures of DHBN domain of Gallus gallus BLM helicase	2016-09-09	2017-03-01	Shi, J.,Chen, W.F.,Zhang, B.,Fan, S.H.,Ai, X.,Liu, N.N.,Rety, S.,Xi, X.G.	A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.	J. Biol. Chem.	2017	292	5909	5920	
5WZ1	28254839	Crystal structure of Zika virus NS5 methyltransferase bound to S-adenosyl-L-methionine	2017-01-16	2017-03-08	Duan, W.,Song, H.,Wang, H.,Chai, Y.,Su, C.,Qi, J.,Shi, Y.,Gao, G.F.	The crystal structure of Zika virus NS5 reveals conserved drug targets.	EMBO J.	2017	36	919	933	
5GON	27805821	Structures of a beta-lactam bridged analogue in complex with tubulin	2016-07-28	2017-03-22	Zhou, P.,Liu, Y.,Zhou, L.,Zhu, K.,Feng, K.,Zhang, H.,Liang, Y.,Jiang, H.,Luo, C.,Liu, M.,Wang, Y.	Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.	J. Med. Chem.	2016	59	10329	10334	
5JFB	27881657	Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163	2016-04-19	2017-03-22	Ma, H.,Jiang, L.,Qiao, S.,Zhi, Y.,Chen, X.X.,Yang, Y.,Huang, X.,Huang, M.,Li, R.,Zhang, G.P.	The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection	J. Virol.	2017	91	0	0	
5IZW	28394309	Crystal structure of RNA editing specific factor of designer PLS-type PPR-9R protein	2016-03-26	2017-03-29	Yan, J.,Zhang, Q.,Guan, Z.,Wang, Q.,Li, L.,Ruan, F.,Lin, R.,Zou, T.,Yin, P.	MORF9 increases the RNA-binding activity of PLS-type pentatricopeptide repeat protein in plastid RNA editing	Nat Plants	2017	3	17037	17037	
5GNK	28282122	Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34	2016-07-21	2017-04-05	Wang, A.,Li, X.,Wu, H.,Zou, F.,Yan, X.E.,Chen, C.,Hu, C.,Yu, K.,Wang, W.,Zhao, P.,Wu, J.,Qi, Z.,Wang, W.,Wang, B.,Wang, L.,Ren, T.,Zhang, S.,Yun, C.H.,Liu, J.,Liu, Q.	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.	J. Med. Chem.	2017	60	2944	2962	
5X3X	28322252	2.8A resolution structure of a cobalt energy-coupling factor transporter-CbiMQO	2017-02-09	2017-04-05	Bao, Z.,Qi, X.,Hong, S.,Xu, K.,He, F.,Zhang, M.,Chen, J.,Chao, D.,Zhao, W.,Li, D.,Wang, J.,Zhang, P.	Structure and mechanism of a group-I cobalt energy coupling factor transporter	Cell Res.	2017	27	675	687	
5J5N		Crystal structure of the R39W mutant of Populus trichocarpa glutathione transferase PtGSTU30 in complex with glutathione	2016-04-03	2017-04-12	Yang, Q.,Han, X.,Gu, J.,Liu, Y.,Yang, M.,Zeng, Q.	Functional and Structural Profiles of GST Gene Family from Three Populus Species Revealed the Sequence-function Decoupling of Orthologous Genes	To Be Published	0	0	0	0	
5JDS	28280600	Crystal structure of PD-L1 complexed with a nanobody at 1.7 Angstron resolution	2016-04-17	2017-04-12	Zhang, F.,Wei, H.,Wang, X.,Bai, Y.,Wang, P.,Wu, J.,Jiang, X.,Wang, Y.,Cai, H.,Xu, T.,Zhou, A.	Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.	Cell Discov	2017	3	17004	17004	
5J87	28315597	Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor	2016-04-07	2017-04-19	Liang, Q.,Chen, Y.,Yu, K.,Chen, C.,Zhang, S.,Wang, A.,Wang, W.,Wu, H.,Liu, X.,Wang, B.,Wang, L.,Hu, Z.,Wang, W.,Ren, T.,Zhang, S.,Liu, Q.,Yun, C.H.,Liu, J.	Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor.	Eur J Med Chem	2017	131	107	125	
5JHE		The Crystal Structure of the Saccharomyces cerevisiae Co-Chaperone Cpr7	2016-04-20	2017-04-26	Yu, Q.,Xu, L.	The Crystal Structure of the Saccharomyces cerevisiae Co-Chaperone Cpr7	To Be Published	0	0	0	0	
5X5V		Crystal structure of pseudorabies virus glycoprotein D	2017-02-17	2017-04-26	Li, A.,Lu, G.,Qi, J.,Wu, L.,Tian, K.,Luo, T.,Shi, Y.,Yan, J.,Gao, G.F.	Crystal structure of pseudorabies virus glycoprotein D	To Be Published	0	0	0	0	
5X5W		Crystal structure of pseudorabies virus glycoprotein D	2017-02-17	2017-04-26	Li, A.,Lu, G.,Qi, J.,Wu, L.,Tian, K.,Luo, T.,Shi, Y.,Yan, J.,Gao, G.F.	Crystal structure of pseudorabies virus glycoprotein D	To Be Published	0	0	0	0	
5XE1	28412361	Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with INCB14943	2017-03-31	2017-05-03	Wu, Y.,Xu, T.,Liu, J.,Ding, K.,Xu, J.	Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943	Biochem. Biophys. Res. Commun.	2017	487	339	343	
5JPS		Structure of the Zika Virus NS3 Helicase Domain	2016-05-04	2017-05-17	Jia, Z.,Wang, J.	Structure of the Zika Virus NS3 Helicase Domain	To Be Published	0	0	0	0	
5X8Y	28198446	A Mutation identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in vitro	2017-03-03	2017-05-17	Wang, D.,Chen, C.,Liu, S.,Zhou, H.,Yang, K.,Zhao, Q.,Ji, X.,Chen, C.,Xie, W.,Wang, Z.,Mi, L.Z.,Yang, H.	A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro	Sci Rep	2017	7	42580	42580	
5B6G	28759015	Protein-protein interaction	2016-05-27	2017-05-31	Jiang, H.,Deng, R.,Yang, X.,Shang, J.,Lu, S.,Zhao, Y.,Song, K.,Liu, X.,Zhang, Q.,Chen, Y.,Chinn, Y.E.,Wu, G.,Li, J.,Chen, G.,Yu, J.,Zhang, J.	Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.	Nat. Chem. Biol.	2017	13	994	1001	
5F5M	28566377	Crystal structure of Marburg virus nucleoprotein core domain	2015-12-04	2017-05-31	Liu, B.,Dong, S.,Li, G.,Wang, W.,Liu, X.,Wang, Y.,Yang, C.,Rao, Z.,Guo, Y.	Structural Insight into Nucleoprotein Conformation Change Chaperoned by VP35 Peptide in Marburg Virus	J. Virol.	2017	91	0	0	
5F5O	28566377	Crystal structure of Marburg virus nucleoprotein core domain bound to VP35 regulation peptide	2015-12-04	2017-05-31	Liu, B.,Dong, S.,Li, G.,Wang, W.,Liu, X.,Wang, Y.,Yang, C.,Rao, Z.,Guo, Y.	Structural Insight into Nucleoprotein Conformation Change Chaperoned by VP35 Peptide in Marburg Virus	J. Virol.	2017	91	0	0	
5GMQ	28472421	Structure of MERS-CoV RBD in complex with a fully human antibody MCA1	2016-07-15	2017-05-31	Chen, Z.,Bao, L.,Chen, C.,Zou, T.,Xue, Y.,Li, F.,Lv, Q.,Gu, S.,Gao, X.,Cui, S.,Wang, J.,Qin, C.,Jin, Q.	Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset.	J. Infect. Dis.	2017	215	1807	1815	
5KWB	28534504	Crystal Structure of the Receptor Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1 (HKU1 1A-CTD, 1.9 angstrom, molecular replacement)	2016-07-17	2017-06-07	Ou, X.,Guan, H.,Qin, B.,Mu, Z.,Wojdyla, J.A.,Wang, M.,Dominguez, S.R.,Qian, Z.,Cui, S.	Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1	Nat Commun	2017	8	15216	15216	
5XBL	28448066	Structure of nuclease in complex with associated protein	2017-03-20	2017-06-14	Guo, M.,Wang, S.,Zhu, Y.,Wang, S.,Xiong, Z.,Yang, J.,Xu, Z.,Huang, Z.	Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein	Nature	2017	546	436	439	
5XDZ	28542875	Crystal structure of zebrafish SNX25 PX domain	2017-03-30	2017-06-14	Su, K.,Xu, T.,Yu, Z.,Zhu, J.,Zhang, Y.,Wu, M.,Xiong, Y.,Liu, J.,Xu, J.	Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain	FEBS Lett.	2017	591	2011	2018	
5XN3	28549582	Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction	2017-05-17	2017-06-14	You, T.,Wang, Y.,Li, K.,Zhang, D.,Wei, H.,Luo, Y.,Li, H.,Lu, Y.,Su, X.,Kuang, Z.	Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.	Biochem. Biophys. Res. Commun.	2017	489	346	352	
5GH9	28815970	Crystal structure of CBP Bromodomain with H3K56ac peptide	2016-06-19	2017-06-21	Xu, L.,Cheng, A.,Huang, M.,Zhang, J.,Jiang, Y.,Wang, C.,Li, F.,Bao, H.,Gao, J.,Wang, N.,Liu, J.,Wu, J.,Wong, C.C.L.,Ruan, K.	Structural insight into CBP bromodomain-mediated recognition of acetylated histone H3K56ac	FEBS J.	2017	0	0	0	
5WRV	28369529	Complex structure of human SRP72/SRP68	2016-12-04	2017-06-21	Gao, Y.,Zhang, Q.,Lang, Y.,Liu, Y.,Dong, X.,Chen, Z.,Tian, W.,Tang, J.,Wu, W.,Tong, Y.,Chen, Z.	Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation	J Mol Cell Biol	2017	9	220	230	
5WWQ	28531330	Crystal structure of human NSun6	2017-01-04	2017-06-28	Liu, R.J.,Long, T.,Li, J.,Li, H.,Wang, E.D.	Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6	Nucleic Acids Res.	2017	45	6684	6697	
5WWR	28531330	Crystal structure of human NSun6/tRNA/SFG	2017-01-04	2017-06-28	Liu, R.J.,Long, T.,Li, J.,Li, H.,Wang, E.D.	Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6	Nucleic Acids Res.	2017	45	6684	6697	
5WWS	28531330	Crystal structure of human NSun6/tRNA/SAM	2017-01-04	2017-06-28	Liu, R.J.,Long, T.,Li, J.,Li, H.,Wang, E.D.	Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6	Nucleic Acids Res.	2017	45	6684	6697	
5WWT	28531330	Crystal structure of human NSun6/tRNA	2017-01-04	2017-06-28	Liu, R.J.,Long, T.,Li, J.,Li, H.,Wang, E.D.	Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6	Nucleic Acids Res.	2017	45	6684	6697	
5WY3	28244370	Crystal structure of Chaetomium thermophilum Utp10 middle domain	2017-01-10	2017-06-28	Sun, Q.,Zhu, X.,Qi, J.,An, W.,Lan, P.,Tan, D.,Chen, R.,Wang, B.,Zheng, S.,Zhang, C.,Chen, X.,Zhang, W.,Chen, J.,Dong, M.Q.,Ye, K.	Molecular architecture of the 90S small subunit pre-ribosome	Elife	2017	6	0	0	
5IZ6	28759015	Protein-protein interaction	2016-03-25	2017-07-05	Jiang, H.,Deng, R.,Yang, X.,Shang, J.,Lu, S.,Zhao, Y.,Song, K.,Liu, X.,Zhang, Q.,Chen, Y.,Chinn, Y.E.,Wu, G.,Li, J.,Chen, G.,Yu, J.,Zhang, J.	Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.	Nat. Chem. Biol.	2017	13	994	1001	
5IZ8	28759015	Protein-protein interaction	2016-03-25	2017-07-05	Jiang, H.,Deng, R.,Yang, X.,Shang, J.,Lu, S.,Zhao, Y.,Song, K.,Liu, X.,Zhang, Q.,Chen, Y.,Chinn, Y.E.,Wu, G.,Li, J.,Chen, G.,Yu, J.,Zhang, J.	Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.	Nat. Chem. Biol.	2017	13	994	1001	
5IZ9	28759015	Protein-protein interaction	2016-03-25	2017-07-05	Jiang, H.,Deng, R.,Yang, X.,Shang, J.,Lu, S.,Zhao, Y.,Song, K.,Liu, X.,Zhang, Q.,Chen, Y.,Chinn, Y.E.,Wu, G.,Li, J.,Chen, G.,Yu, J.,Zhang, J.	Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.	Nat. Chem. Biol.	2017	13	994	1001	
5IZA	28759015	Protein-protein interaction	2016-03-25	2017-07-05	Jiang, H.,Deng, R.,Yang, X.,Shang, J.,Lu, S.,Zhao, Y.,Song, K.,Liu, X.,Zhang, Q.,Chen, Y.,Chinn, Y.E.,Wu, G.,Li, J.,Chen, G.,Yu, J.,Zhang, J.	Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.	Nat. Chem. Biol.	2017	13	994	1001	
5WWP	28651017	Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13)	2017-01-03	2017-07-05	Hao, W.,Wojdyla, J.A.,Zhao, R.,Han, R.,Das, R.,Zlatev, I.,Manoharan, M.,Wang, M.,Cui, S.	Crystal structure of Middle East respiratory syndrome coronavirus helicase	PLoS Pathog.	2017	13	0	0	
5WUC	28524849	Structural basis for conductance through TRIC cation channels	2016-12-17	2017-07-12	Su, M.,Gao, F.,Yuan, Q.,Mao, Y.,Li, D.L.,Guo, Y.,Yang, C.,Wang, X.H.,Bruni, R.,Kloss, B.,Zhao, H.,Zeng, Y.,Zhang, F.B.,Marks, A.R.,Hendrickson, W.A.,Chen, Y.H.	Structural basis for conductance through TRIC cation channels.	Nat Commun	2017	8	15103	15103	
5GMR	28733281	Crystal structure of the mutant M3+S202W/I203F of the esterase E40	2016-07-15	2017-07-19	Li, P.Y.,Zhang, Y.,Xie, B.B.,Zhang, Y.Q.,Hao, J.,Wang, Y.,Wang, P.,Li, C.Y.,Qin, Q.L.,Zhang, X.Y.,Su, H.N.,Shi, M.,Zhang, Y.Z.,Chen, X.L.	Structural and Mechanistic Insights into the Improvement of the Halotolerance of a Marine Microbial Esterase by Increasing Intra- and Interdomain Hydrophobic Interactions.	Appl. Environ. Microbiol.	2017	83	0	0	
5GMS	28733281	Crystal structure of the mutant S202W/I203F of the esterase E40	2016-07-15	2017-07-19	Li, P.Y.,Zhang, Y.,Xie, B.B.,Zhang, Y.Q.,Hao, J.,Wang, Y.,Wang, P.,Li, C.Y.,Qin, Q.L.,Zhang, X.Y.,Su, H.N.,Shi, M.,Zhang, Y.Z.,Chen, X.L.	Structural and Mechanistic Insights into the Improvement of the Halotolerance of a Marine Microbial Esterase by Increasing Intra- and Interdomain Hydrophobic Interactions.	Appl. Environ. Microbiol.	2017	83	0	0	
5GXT	28258005	Crystal structure of PigG	2016-09-20	2017-07-19	Zhang, F.,Wei, Q.,Tong, H.,Xu, D.,Wang, W.,Ran, T.	Crystal structure of MBP-PigG fusion protein and the essential function of PigG in the prodigiosin biosynthetic pathway in Serratia marcescens FS14.	Int. J. Biol. Macromol.	2017	99	394	400	
5GXV	28258005	Crystal structure of PigG	2016-09-20	2017-07-19	Zhang, F.,Wei, Q.,Tong, H.,Xu, D.,Wang, W.,Ran, T.	Crystal structure of MBP-PigG fusion protein and the essential function of PigG in the prodigiosin biosynthetic pathway in Serratia marcescens FS14.	Int. J. Biol. Macromol.	2017	99	394	400	
5XUN	29461656	Crystal structure of Y145F mutant of KacT	2017-06-23	2017-07-19	Qian, H.,Yao, Q.,Tai, C.,Deng, Z.,Gan, J.,Ou, H.Y.	Identification and characterization of acetyltransferase-type toxin-antitoxin locus in Klebsiella pneumoniae	Mol. Microbiol.	2018	108	336	349	
5H73		Crystal structure of human DHODH with 18F	2016-11-16	2017-07-26	Huang, J.,Wu, D.	Crystal structure of human DHODH with 18F at 1.58 Angstroms resolution	To Be Published	0	0	0	0	
5XQ1	28739949	Structural basis of kindlin-mediated integrin recognition and activation	2017-06-05	2017-07-26	Li, H.,Deng, Y.,Sun, K.,Yang, H.,Liu, J.,Wang, M.,Zhang, Z.,Lin, J.,Wu, C.,Wei, Z.,Yu, C.	Structural basis of kindlin-mediated integrin recognition and activation	Proc. Natl. Acad. Sci. U.S.A.	2017	114	9349	9354	
5XL2	28768203	The structure of hemagglutininfrom a swine-origin H4N6 influenza virus	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XL3	28768203	Complex structure of H4 hemagglutinin from avian influenza H4N6 virus with LSTa	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XL4	28768203	The structure of hemagglutinin from an avian-origin H4N6 influenza virus in complex with human receptor analog Lstc	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XL5	28768203	The structure of hemagglutinin Q226L mutant from an avian-origin H4N6 influenza virus	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XL6	28768203	The structure of hemagglutinin Q226L mutant from a avian-origin H4N6 influenza virus	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XL7	28768203	The structure of hemagglutinin Q226L mutant from an avian-origin H4N6 influenza virus in complex with human receptor analog LSTc	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XL8	28768203	The structure of hemagglutinin G228S mutant from a avian-origin H4N6 influenza virus (A/duck/Czech/1956)	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XL9	28768203	The structure of hemagglutinin G228S mutant from an avian-origin H4N6 influenza virus in complex with avian receptor analog LSTa	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XLA	28768203	The structure of hemagglutinin G228S mutant from an avian-origin H4N6 influenza virus in complex with human receptor analog LSTc	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XLB	28768203	The structure of hemagglutinin Q226L-G228S mutant from an avian-origin H4N6 influenza virus	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XLC	28768203	The structure of hemagglutinin Q226L-G228S mutant from an avian-origin H4N6 influenza virus in complex with avian receptor analog LSTa	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5XLD	28768203	The structure of hemagglutinin Q226L-G228S mutant from an avian-origin H4N6 influenza virus in complex with human receptor analog LSTc	2017-05-10	2017-08-02	Song, H.,Qi, J.,Xiao, H.,Bi, Y.,Zhang, W.,Xu, Y.,Wang, F.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4	Cell Rep	2017	20	1201	1214	
5GQ9		Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target	2016-08-06	2017-08-09	Zhao, H.,Sheng, G.,Wang, Y.	Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target	To Be Published	0	0	0	0	
5GRN		Crystal structure of PDGFRA in Complex with WQ-C-159	2016-08-11	2017-08-16	Yan, X.E.,Yun, C.H.	Crystal Structure of PDGFRA in Complex with WQ-C-159	To Be Published	0	0	0	0	
5WZZ	28546513	The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation	2017-01-19	2017-08-16	Ji, L.,Jiang, B.,Jiang, X.,Charlat, O.,Chen, A.,Mickanin, C.,Bauer, A.,Xu, W.,Yan, X.-X.,Cong, F.	The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation	Genes Dev.	2017	31	904	915	
5XEU	28777089	crystal structure of Hcp2 from Salmonella typhimurium	2017-04-06	2017-08-16	Lin, Q.P.,Gao, Z.Q.,Geng, Z.,Zhang, H.,Dong, Y.H.	Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimurium	Acta Crystallogr F Struct Biol	2017	73	463	468	
5XLX	28777083	Crystal structure of the C-terminal domain of CheR1 containing SAH	2017-05-12	2017-08-23	Zhu, Y.,Yuan, Z.,Gu, L.	Structural basis for the regulation of chemotaxis by MapZ in the presence of c-di-GMP	Acta Crystallogr D Struct Biol	2017	73	683	691	
5XLY	28777083	Crystal structure of CheR1 in complex with c-di-GMP-bound MapZ	2017-05-12	2017-08-23	Zhu, Y.,Yuan, Z.,Gu, L.	Structural basis for the regulation of chemotaxis by MapZ in the presence of c-di-GMP	Acta Crystallogr D Struct Biol	2017	73	683	691	
5X5L	28934482	Crystal structure of response regulator AdeR DNA binding domain in complex with an intercistronic region	2017-02-16	2017-08-30	Wen, Y.,Ouyang, Z.,Yu, Y.,Zhou, X.,Pei, Y.,Devreese, B.,Higgins, P.G.,Zheng, F.	Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region.	Nucleic Acids Res.	2017	45	9773	9787	
5Y4Z		Crystal structure of the Zika virus NS3 helicase complex with AMPPNP	2017-08-06	2017-08-30	Li, L.,Wang, J.,Jia, Z.,Shaw, N.	Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA	Acta Crystallogr.,Sect.F	2018	74	205	213	
5GTY	28407693	Crystal structure of EGFR 696-1022 T790M in complex with LXX-6-26	2016-08-23	2017-09-06	Hu, C.,Wang, A.,Wu, H.,Qi, Z.,Li, X.,Yan, X.E.,Chen, C.,Yu, K.,Zou, F.,Wang, W.,Wang, W.,Wu, J.,Liu, J.,Wang, B.,Wang, L.,Ren, T.,Zhang, S.,Yun, C.H.,Liu, J.,Liu, Q.	Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode.	Oncotarget	2017	8	18359	18372	
5GUT	29381856	The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A	2016-08-31	2017-09-06	Ye, F.,Kong, X.,Zhang, H.,Liu, Y.,Shao, Z.,Jin, J.,Cai, Y.,Zhang, R.,Li, L.,Zhang, Y.W.,Liu, Y.C.,Zhang, C.,Xie, W.,Yu, K.,Ding, H.,Zhao, K.,Chen, S.,Jiang, H.,Baylin, S.B.,Luo, C.	Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.	ACS Chem. Biol.	2018	13	772	781	
5XVM	30395931	Sterol 3-beta-glucosyltransferase (ugt51) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	2017-06-28	2017-09-06	Chen, L.-Q.,Zhang, Y.,Feng, Y.	Structural dissection of sterol glycosyltransferase UGT51 from Saccharomyces cerevisiae for substrate specificity.	J. Struct. Biol.	2018	204	371	379	
5XFQ	28869966	Ternary complex of PHF1, a DNA duplex and a histone peptide	2017-04-11	2017-09-13	Li, H.,Liefke, R.,Jiang, J.,Kurland, J.V.,Tian, W.,Deng, P.,Zhang, W.,He, Q.,Patel, D.J.,Bulyk, M.L.,Shi, Y.,Wang, Z.	Polycomb-like proteins link the PRC2 complex to CpG islands	Nature	2017	549	287	291	
5XFR	28869966	Ternary complex of MTF2, DNA and histone	2017-04-11	2017-09-13	Li, H.,Liefke, R.,Jiang, J.,Kurland, J.V.,Tian, W.,Deng, P.,Zhang, W.,He, Q.,Patel, D.J.,Bulyk, M.L.,Shi, Y.,Wang, Z.	Polycomb-like proteins link the PRC2 complex to CpG islands	Nature	2017	549	287	291	
5Y56	28878018	Fc mutant (K392D/K409D/D399K)	2017-08-07	2017-09-13	Yu, J.,Wang, X.,Xu, T.,Jin, Q.,Duan, J.,Wu, J.,Wu, H.,Xu, T.,Ye, S.	A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line	J. Biol. Chem.	2017	292	17885	17896	
5GRQ		Crystal Structure of DHB domain of Daxx in complex with an ATRX peptide	2016-08-12	2017-09-27	Li, H.	Crystal Structure of DHB domain of Daxx in complex with an ATRX peptide	To be published	0	0	0	0	
5WZJ	29036323	Structure of APUM23-GGAUUUGACGG	2017-01-18	2017-09-27	Bao, H.,Wang, N.,Wang, C.,Jiang, Y.,Liu, J.,Xu, L.,Wu, J.,Shi, Y.	Structural basis for the specific recognition of 18S rRNA by APUM23.	Nucleic Acids Res.	2017	45	12005	12014	
5WZK	29036323	Structure of APUM23-deletion-of-insert-region-GGAAUUGACGG	2017-01-18	2017-09-27	Bao, H.,Wang, N.,Wang, C.,Jiang, Y.,Liu, J.,Xu, L.,Wu, J.,Shi, Y.	Structural basis for the specific recognition of 18S rRNA by APUM23.	Nucleic Acids Res.	2017	45	12005	12014	
5GZX		The complex structure of D-2-haloacid dehalogenase mutant with D-2-CPA	2016-10-02	2017-10-04	Wang, Y.,Xue, S.	The complex structure of D-2-haloacid dehalogenase mutant with D-2-CPA	To Be Published	0	0	0	0	
5H01		The crystal structure of D-2-halacid dehalogenase mutant	2016-10-02	2017-10-04	Xue, S.,Wang, Y.	The crystal structure of D-2-halacid dehalogenase mutant	To Be Published	0	0	0	0	
5WQN	28524228	Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 (condition II)	2016-11-27	2017-10-04	Li, S.,Teng, X.,Su, L.,Mao, G.,Xu, Y.,Li, T.,Liu, R.,Zhang, Q.,Wang, Y.,Bartlam, M.	Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1.	FEBS Lett.	2017	591	1785	1797	
5WQO	28524228	Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 in complex with NADP (condition I)	2016-11-27	2017-10-04	Li, S.,Teng, X.,Su, L.,Mao, G.,Xu, Y.,Li, T.,Liu, R.,Zhang, Q.,Wang, Y.,Bartlam, M.	Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1.	FEBS Lett.	2017	591	1785	1797	
5WQP	28524228	Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 in complex with NADP (condition II)	2016-11-27	2017-10-04	Li, S.,Teng, X.,Su, L.,Mao, G.,Xu, Y.,Li, T.,Liu, R.,Zhang, Q.,Wang, Y.,Bartlam, M.	Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1.	FEBS Lett.	2017	591	1785	1797	
5WQT	28928145	Structure of a protein involved in pyroptosis	2016-11-28	2017-10-04	Kuang, S.,Zheng, J.,Yang, H.,Li, S.,Duan, S.,Shen, Y.,Ji, C.,Gan, J.,Xu, X.W.,Li, J.	Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.	Proc. Natl. Acad. Sci. U.S.A.	2017	114	10642	10647	
5XQ2	28911094	Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand	2017-06-06	2017-10-04	Sheng, G.,Gogakos, T.,Wang, J.,Zhao, H.,Serganov, A.,Juranek, S.,Tuschl, T.,Patel, D.J.,Wang, Y.	Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes	Nucleic Acids Res.	2017	45	9149	9163	
5GUF	28961231	Structural insight into an intramembrane enzyme for archaeal membrane lipids biosynthesis	2016-08-29	2017-10-11	Ren, S.,Caforio, A.,Yang, Q.,Sun, B.,Yu, F.,Zhu, X.,Wang, J.,Dou, C.,Fu, Q.,Huang, N.,Sun, Q.,Nie, C.,Qi, S.,Gong, X.,He, J.,Wei, Y.,Driessen, A.J.,Cheng, W.	Structural and mechanistic insights into the biosynthesis of CDP-archaeol in membranes.	Cell Res.	2017	27	1378	1391	
5XGM	28456628	Crystal structure of EGFR 696-1022 T790M in complex with Go6976	2017-04-14	2017-10-11	Kong, L.L.,Ma, R.,Yao, M.Y.,Yan, X.E.,Zhu, S.J.,Zhao, P.,Yun, C.H.	Structural pharmacological studies on EGFR T790M/C797S.	Biochem. Biophys. Res. Commun.	2017	488	266	272	
5XGN	28456628	Crystal structure of EGFR 696-1022 T790M/C797S in complex with Go6976	2017-04-14	2017-10-11	Kong, L.L.,Ma, R.,Yao, M.Y.,Yan, X.E.,Zhu, S.J.,Zhao, P.,Yun, C.H.	Structural pharmacological studies on EGFR T790M/C797S.	Biochem. Biophys. Res. Commun.	2017	488	266	272	
5YGE	28943401	ArgA complexed with AceCoA and glutamate	2017-09-22	2017-10-11	Yang, X.,Wu, L.,Ran, Y.,Xu, A.,Zhang, B.,Yang, X.,Zhang, R.,Rao, Z.,Li, J.	Crystal structure of l-glutamate N-acetyltransferase ArgA from Mycobacterium tuberculosis	Biochim. Biophys. Acta	2017	1865	1800	1807	
5X3G	28977725	The WT UNG crystal structure from Nitratifractor salsuginis	2017-02-06	2017-10-18	Li, J.,Chen, R.,Yang, Y.,Zhang, Z.,Fang, G.C.,Xie, W.,Cao, W.	An unconventional family 1 uracil DNA glycosylase in Nitratifractor salsuginis.	FEBS J.	2017	284	4017	4034	
5XEX	28960276	Crystal structure of S.aureus PNPase catalytic domain	2017-04-06	2017-10-18	Wang, X.,Wang, C.,Wu, M.,Tian, T.,Cheng, T.,Zhang, X.,Zang, J.	Enolase binds to RnpA in competition with PNPase in Staphylococcus aureus	FEBS Lett.	2017	591	3523	3535	
5X04	28991437	12:0-ACP thioesterase from Umbellularia californica	2017-01-19	2017-10-25	Feng, Y.,Wang, Y.,Liu, J.,Liu, Y.,Cao, X.,Xue, S.	Structural Insight into Acyl-ACP Thioesterase toward Substrate Specificity Design.	ACS Chem. Biol.	2017	12	2830	2836	
5XP3	29691282	Crystal structure of apo T2R-TTL	2017-05-31	2017-10-25	Jianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C.	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.	J. Biol. Chem.	2018	0	0	0	
5WTI	28374750	Crystal structure of the CRISPR-associated protein in complex with crRNA and DNA	2016-12-13	2017-11-01	Wu, D.,Guan, X.,Zhu, Y.,Ren, K.,Huang, Z.	Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA	Cell Res.	2017	27	705	708	
5XJ2	28949991	Structure of spRlmCD with U747 RNA	2017-04-28	2017-11-01	Jiang, Y.,Li, F.,Wu, J.,Shi, Y.,Gong, Q.	Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD	PLoS ONE	2017	12	0	0	
5YDU	28951391	Crystal structure of Utp30	2017-09-14	2017-11-01	Hu, J.,Zhu, X.,Ye, K.	Structure and RNA recognition of ribosome assembly factor Utp30.	RNA	2017	23	1936	1945	
5H4D		Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride	2016-10-31	2017-11-08	Zhang, S.,Fu, L.,Liu, J.,Liu, B.	Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride	To Be Published	0	0	0	0	
5XYN	29069504	The crystal structure of Csm2-Psy3-Shu1-Shu2 complex from budding yeast	2017-07-09	2017-11-08	Zhang, S.,Wang, L.,Tao, Y.,Bai, T.,Lu, R.,Zhang, T.,Chen, J.,Ding, J.	Structural basis for the functional role of the Shu complex in homologous recombination.	Nucleic Acids Res.	2017	45	13068	13079	
5WWD	29066356	Crystal structure of AtNUDX1	2016-12-31	2017-11-15	Liu, J.,Guan, Z.,Liu, H.,Qi, L.,Zhang, D.,Zou, T.,Yin, P.	Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.	Mol Plant	2018	11	218	221	
5WY6	29066356	Crystal structure of AtNUDX1 (E56A)	2017-01-11	2017-11-15	Liu, J.,Guan, Z.,Liu, H.,Qi, L.,Zhang, D.,Zou, T.,Yin, P.	Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.	Mol Plant	2018	11	218	221	
5H74		Crystal structure of T2R-TTL-14b complex	2016-11-17	2017-11-22	Wang, Y.,Yu, Y.,Chen, Q.,Yang, J.	Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin	To Be Published	0	0	0	0	
5Y85	29081514	Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme	2017-08-18	2017-11-22	Zheng, L.,Mairhofer, E.,Teplova, M.,Zhang, Y.,Ma, J.,Patel, D.J.,Micura, R.,Ren, A.	Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme	Nat Commun	2017	8	1180	1180	
5Y87	29081514	Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme	2017-08-19	2017-11-22	Zheng, L.,Mairhofer, E.,Teplova, M.,Zhang, Y.,Ma, J.,Patel, D.J.,Micura, R.,Ren, A.	Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme	Nat Commun	2017	8	1180	1180	
5XKU	29212936	Crystal structure of hemagglutinin globular head from an H7N9 influenza virus in complex with a neutralizing antibody HNIgGA6	2017-05-09	2017-11-29	Chen, C.,Liu, L.,Xiao, Y.,Cui, S.,Wang, J.,Jin, Q.	Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9	J. Virol.	2018	92	0	0	
5YBB	28973912	Structural basis underlying complex assembly andconformational transition of the type I R-M system	2017-09-04	2017-11-29	Liu, Y.P.,Tang, Q.,Zhang, J.Z.,Tian, L.F.,Gao, P.,Yan, X.X.	Structural basis underlying complex assembly and conformational transition of the type I R-M system.	Proc. Natl. Acad. Sci. U.S.A.	2017	114	11151	11156	
5YBE	29158259	Structure of KANK1/KIF21A complex	2017-09-04	2017-11-29	Weng, Z.,Shang, Y.,Yao, D.,Zhu, J.,Zhang, R.	Structural analyses of key features in the KANK1/KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex.	J. Biol. Chem.	2018	293	215	225	
5YEG	29076501	Crystal structure of CTCF ZFs4-8-Hs5-1a complex	2017-09-17	2017-11-29	Yin, M.,Wang, J.,Wang, M.,Li, X.,Zhang, M.,Wu, Q.,Wang, Y.	Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites	Cell Res.	2017	27	1365	1377	
5YEH	29076501	Crystal structure of CTCF ZFs4-8-eCBS	2017-09-17	2017-11-29	Yin, M.,Wang, J.,Wang, M.,Li, X.,Zhang, M.,Wu, Q.,Wang, Y.	Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites	Cell Res.	2017	27	1365	1377	
5WS2	28795788	Crystal structure of mpy-RNase J (mutant S247A), an archaeal RNase J from Methanolobus psychrophilus R15, complex with RNA	2016-12-05	2017-12-06	Zheng, X.,Feng, N.,Li, D.,Dong, X.,Li, J.	New molecular insights into an archaeal RNase J reveal a conserved processive exoribonucleolysis mechanism of the RNase J family	Mol. Microbiol.	2017	106	351	366	
5X5M	29133784	Crystal structure of a hydrolase encoded by lin2189 from Listeria innocua	2017-02-16	2017-12-06	Yuan, H.,Zhang, J.,Cai, Y.,Wu, S.,Yang, K.,Chan, H.C.S.,Huang, W.,Jin, W.B.,Li, Y.,Yin, Y.,Igarashi, Y.,Yuan, S.,Zhou, J.,Tang, G.L.	GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection	Nat Commun	2017	8	1485	1485	
5XJZ	28635152	Structure of DNA1-Ag complex	2017-05-04	2017-12-06	Liu, H.H.,Shen, F.S.,Haruehanroengra, P.,Yao, Q.Q.,Cheng, Y.S.,Chen, Y.Q.,Yang, C.,Zhang, J.,Wu, B.X.,Luo, Q.,Cui, R.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H.	A DNA Structure Containing AgI -Mediated G:G and C:C Base Pairs	Angew. Chem. Int. Ed. Engl.	2017	56	9430	9434	
5XK0	28635152	Structure of 8-mer DNA2	2017-05-04	2017-12-06	Liu, H.H.,Shen, F.S.,Haruehanroengra, P.,Yao, Q.Q.,Cheng, Y.S.,Chen, Y.Q.,Yang, C.,Zhang, J.,Wu, B.X.,Luo, Q.,Cui, R.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H.	A DNA Structure Containing AgI -Mediated G:G and C:C Base Pairs	Angew. Chem. Int. Ed. Engl.	2017	56	9430	9434	
5XK1	28635152	Structure of 8-mer DNA3	2017-05-04	2017-12-06	Liu, H.H.,Shen, F.S.,Haruehanroengra, P.,Yao, Q.Q.,Cheng, Y.S.,Chen, Y.Q.,Yang, C.,Zhang, J.,Wu, B.X.,Luo, Q.,Cui, R.X.,Li, J.X.,Ma, J.B.,Sheng, J.,Gan, J.H.	A DNA Structure Containing AgI -Mediated G:G and C:C Base Pairs.	Angew. Chem. Int. Ed. Engl.	2017	56	9430	9434	
5YI2	29229866	Structure of Lactococcus lactis ZitR, wild type in complex with DNA	2017-10-01	2017-12-06	Zhu, R.,Song, Y.,Liu, H.,Yang, Y.,Wang, S.,Yi, C.,Chen, P.R.	Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation.	Proc.Natl.Acad.Sci.USA	2017	114	13661	13666	
5YJ3	29134956	Crystal structure of TZAP and telomeric DNA complex	2017-10-07	2017-12-06	Zhao, Y.,Zhang, G.,He, C.,Mei, Y.,Shi, Y.,Li, F.	The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA.	Cell Res.	2018	28	130	134	
5H7O	29180476	Crystal structure of DJ-101 in complex with tubulin protein	2016-11-20	2017-12-13	Arnst, K.E.,Wang, Y.,Hwang, D.J.,Xue, Y.,Costello, T.,Hamilton, D.,Chen, Q.,Yang, J.,Park, F.,Dalton, J.T.,Miller, D.D.,Li, W.	A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.	Cancer Res.	2018	78	265	277	
5O6D	29202194	Structure of ScPif1 in complex with polydT and ATPgS	2017-06-06	2017-12-13	Lu, K.Y.,Chen, W.F.,Rety, S.,Liu, N.N.,Wu, W.Q.,Dai, Y.X.,Li, D.,Ma, H.Y.,Dou, S.X.,Xi, X.G.	Insights into the structural and mechanistic basis of multifunctional S. cerevisiae Pif1p helicase.	Nucleic Acids Res.	2018	46	1486	1500	
5WT3	29214216	Pyrococcus abyssi methyltransferase PaTrm5a bound by MTA and cognate tRNA	2016-12-09	2017-12-13	Wang, C.,Jia, Q.,Zeng, J.,Chen, R.,Xie, W.	Structural insight into the methyltransfer mechanism of the bifunctional Trm5.	Sci Adv	2017	3	0	0	
5XZR	29155585	The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b	2017-07-13	2017-12-13	Xie, J.,Si, X.,Gu, S.,Wang, M.,Shen, J.,Li, H.,Shen, J.,Li, D.,Fang, Y.,Liu, C.,Zhu, J.	Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.	J. Med. Chem.	2017	60	10205	10219	
5XAF	29306206	Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex	2017-03-12	2017-12-20	Zhou, P.,Liang, Y.,Zhang, H.,Jiang, H.,Feng, K.,Xu, P.,Wang, J.,Wang, X.,Ding, K.,Luo, C.,Liu, M.,Wang, Y.	Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents	Eur J Med Chem	2017	144	817	842	
5Y58	29290466	Crystal structure of Ku70/80 and TLC1	2017-08-08	2017-12-20	Chen, H.,Xue, J.,Churikov, D.,Hass, E.P.,Shi, S.,Lemon, L.D.,Luciano, P.,Bertuch, A.A.,Zappulla, D.C.,Geli, V.,Wu, J.,Lei, M.	Structural Insights into Yeast Telomerase Recruitment to Telomeres	Cell	2018	172	331	0	
5Y59	29290466	Crystal structure of Ku80 and Sir4	2017-08-08	2017-12-20	Chen, H.,Xue, J.,Churikov, D.,Hass, E.P.,Shi, S.,Lemon, L.D.,Luciano, P.,Bertuch, A.A.,Zappulla, D.C.,Geli, V.,Wu, J.,Lei, M.	Structural Insights into Yeast Telomerase Recruitment to Telomeres	Cell	2018	172	331	0	
5Y5A	29290466	Crystal structure of Est1 and Cdc13	2017-08-08	2017-12-20	Chen, H.,Xue, J.,Churikov, D.,Hass, E.P.,Shi, S.,Lemon, L.D.,Luciano, P.,Bertuch, A.A.,Zappulla, D.C.,Geli, V.,Wu, J.,Lei, M.	Structural Insights into Yeast Telomerase Recruitment to Telomeres	Cell	2018	172	331	0	
5YAZ	29217769	Crystal structure of the ANKRD domain of KANK1	2017-09-02	2017-12-20	Pan, W.,Sun, K.,Tang, K.,Xiao, Q.,Ma, C.,Yu, C.,Wei, Z.	Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion.	J. Biol. Chem.	2018	293	1944	1956	
5YDE	29142233	Crystal structure of a disease-related gene, hCDC73(1-111)	2017-09-13	2017-12-20	Sun, W.,Kuang, X.L.,Liu, Y.P.,Tian, L.F.,Yan, X.X.,Xu, W.	Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome	Sci Rep	2017	7	15638	15638	
5YDF	29142233	Crystal structure of a disease-related gene, hCDC73(1-100)	2017-09-13	2017-12-20	Sun, W.,Kuang, X.L.,Liu, Y.P.,Tian, L.F.,Yan, X.X.,Xu, W.	Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome	Sci Rep	2017	7	15638	15638	
5YDF	29142233	Crystal structure of a disease-related gene, hCDC73(1-100)	2017-09-13	2017-12-20	Sun, W.,Kuang, X.L.,Liu, Y.P.,Tian, L.F.,Yan, X.X.,Xu, W.	Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome	Sci Rep	2017	7	15638	15638	
5X5O	28586211	Crystal structure of ZAK in complex with compound D2829	2017-02-17	2017-12-27	Chang, Y.,Lu, X.,Shibu, M.A.,Dai, Y.B.,Luo, J.,Zhang, Y.,Li, Y.,Zhao, P.,Zhang, Z.,Xu, Y.,Tu, Z.C.,Zhang, Q.W.,Yun, C.H.,Huang, C.Y.,Ding, K.	Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.	J. Med. Chem.	2017	60	5927	5932	
5Y3X	29236500	Crystal structure of endo-1,4-beta-xylanase from Caldicellulosiruptor owensensis	2017-07-31	2017-12-27	Liu, X.,Liu, T.,Zhang, Y.,Xin, F.,Mi, S.,Wen, B.,Gu, T.,Shi, X.,Wang, F.,Sun, L.	Structural Insights into the Thermophilic Adaption Mechanism of Endo-1,4-beta-Xylanase from Caldicellulosiruptor owensensis.	J. Agric. Food Chem.	2018	66	187	193	
5YKN	29233856	crystal structure of Arabidopsis thaliana JMJ14 catalytic domain	2017-10-15	2017-12-27	Yang, Z.,Qiu, Q.,Chen, W.,Jia, B.,Chen, X.,Hu, H.,He, K.,Deng, X.,Li, S.,Tao, W.A.,Cao, X.,Du, J.	Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.	Plant Cell	2018	30	167	177	
5YKO	29233856	Crystal structure of Arabidopsis thaliana JMJ14 catalytic domain in complex with NOG and H3K4me3 peptide	2017-10-15	2017-12-27	Yang, Z.,Qiu, Q.,Chen, W.,Jia, B.,Chen, X.,Hu, H.,He, K.,Deng, X.,Li, S.,Tao, W.A.,Cao, X.,Du, J.	Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.	Plant Cell	2018	30	167	177	
5WVM	28544098	Crystal structure of baeS cocrystallized with 2 mM indole	2016-12-26	2018-01-03	Zhang, Y.,Qiu, S.,Jia, S.,Xu, D.,Ran, T.,Wang, W.	Crystal structure of the sensor domain of BaeS from Serratia marcescens FS14	Proteins	2017	85	1784	1790	
5WVN	28544098	Crystal structure of MBS-BaeS fusion protein	2016-12-26	2018-01-03	Zhang, Y.,Qiu, S.,Jia, S.,Xu, D.,Ran, T.,Wang, W.	Crystal structure of the sensor domain of BaeS from Serratia marcescens FS14	Proteins	2017	85	1784	1790	
5XAG	29306206	Crystal structure of tubulin-stathmin-TTL-Compound Z2 complex	2017-03-12	2018-01-03	Zhou, P.,Liang, Y.,Zhang, H.,Jiang, H.,Feng, K.,Xu, P.,Wang, J.,Wang, X.,Ding, K.,Luo, C.,Liu, M.,Wang, Y.	Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents	Eur J Med Chem	2017	144	817	842	
5YFB	29050944	Crystal structure of a new DPP III family member	2017-09-20	2018-01-03	Xu, T.,Xie, C.,Yao, D.,Zhou, C.Z.,Liu, J.	Crystal structures of Aflatoxin-oxidase from Armillariella tabescens reveal a dual activity enzyme.	Biochem. Biophys. Res. Commun.	2017	494	621	625	
5Z0W	29321334	Crystal structure of HIV-1 fusion inhibitor SC29EK complexed with gp41 NHR (N36)	2017-12-21	2018-01-10	Wu, X.,Liu, Z.,Ding, X.,Yu, D.,Wei, H.,Qin, B.,Zhu, Y.,Chong, H.,Cui, S.,He, Y.	Mechanism of HIV-1 Resistance to an Electronically Constrained alpha-Helical Peptide Membrane Fusion Inhibitor	J. Virol.	2018	92	0	0	
5XM8	29222499	Crystal structure of AsfvPolX in complex with DNA enzyme and Pb.	2017-05-13	2018-01-24	Liu, H.,Yu, X.,Chen, Y.,Zhang, J.,Wu, B.,Zheng, L.,Haruehanroengra, P.,Wang, R.,Li, S.,Lin, J.,Li, J.,Sheng, J.,Huang, Z.,Ma, J.,Gan, J.	Crystal structure of an RNA-cleaving DNAzyme.	Nat Commun	2017	8	2006	2006	
5XM9	29222499	Crystal structure of AsfvPolX in complex with DNA enzyme.	2017-05-13	2018-01-24	Liu, H.,Yu, X.,Chen, Y.,Zhang, J.,Wu, B.,Zheng, L.,Haruehanroengra, P.,Wang, R.,Li, S.,Lin, J.,Li, J.,Sheng, J.,Huang, Z.,Ma, J.,Gan, J.	Crystal structure of an RNA-cleaving DNAzyme.	Nat Commun	2017	8	2006	2006	
5XMA	29222499	Crystal structure of AsfvPolX in complex with DNA enzyme at P43212 space group	2017-05-13	2018-01-24	Liu, H.,Yu, X.,Chen, Y.,Zhang, J.,Wu, B.,Zheng, L.,Haruehanroengra, P.,Wang, R.,Li, S.,Lin, J.,Li, J.,Sheng, J.,Huang, Z.,Ma, J.,Gan, J.	Crystal structure of an RNA-cleaving DNAzyme.	Nat Commun	2017	8	2006	2006	
5XNP	29348579	Crystal structures of human SALM5 in complex with human PTPdelta	2017-05-24	2018-01-24	Lin, Z.,Liu, J.,Ding, H.,Xu, F.,Liu, H.	Structural basis of SALM5-induced PTP delta dimerization for synaptic differentiation	Nat Commun	2018	9	268	268	
5XNQ	29348579	Crystal structures of human SALM5	2017-05-24	2018-01-24	Lin, Z.,Liu, J.,Ding, H.,Xu, F.,Liu, H.	Structural basis of SALM5-induced PTP delta dimerization for synaptic differentiation	Nat Commun	2018	9	268	268	
5Y0V	30135205	Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with berberine	2017-07-18	2018-01-24	Duan, Y.,Liu, T.,Zhou, Y.,Dou, T.,Yang, Q.	Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine.	J. Biol. Chem.	2018	293	15429	15438	
5Y1B	30135205	Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with a berberine derivative (SYSU-00679)	2017-07-20	2018-01-24	Duan, Y.,Liu, T.,Zhou, Y.,Dou, T.,Yang, Q.	Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine.	J. Biol. Chem.	2018	293	15429	15438	
5Y26	29109278	Crystal structure of native Dpb4-Dpb3	2017-07-24	2018-01-24	He, H.,Li, Y.,Dong, Q.,Chang, A.Y.,Gao, F.,Chi, Z.,Su, M.,Zhang, F.,Ban, H.,Martienssen, R.,Chen, Y.H.,Li, F.	Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex.	Proc. Natl. Acad. Sci. U.S.A.	2017	114	12524	12529	
5Y27	29109278	Crystal structure of Se-Met Dpb4-Dpb3	2017-07-24	2018-01-24	He, H.,Li, Y.,Dong, Q.,Chang, A.Y.,Gao, F.,Chi, Z.,Su, M.,Zhang, F.,Ban, H.,Martienssen, R.,Chen, Y.H.,Li, F.	Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex.	Proc. Natl. Acad. Sci. U.S.A.	2017	114	12524	12529	
5Y6D	29353720	VIM-2 metallo-beta-lactamase in complex with (R)-2-(4-fluorophenyl)-2-((S)-3-mercapto-2-methylpropanamido)acetic acid (compound 11)	2017-08-11	2018-01-24	Liu, S.,Jing, L.,Yu, Z.-J.,Wu, C.,Zheng, Y.,Zhang, E.,Chen, Q.,Yu, Y.,Guo, L.,Wu, Y.,Li, G.-B.	((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-beta-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.	Eur J Med Chem	2018	145	649	660	
5Y6E	29353720	VIM-2 metallo-beta-lactamase in complex with (R)-2-(4-hydroxyphenyl)-2-((S)-3-mercapto-2-methylpropanamido)acetic acid (compound 12)	2017-08-11	2018-01-24	Liu, S.,Jing, L.,Yu, Z.-J.,Wu, C.,Zheng, Y.,Zhang, E.,Chen, Q.,Yu, Y.,Guo, L.,Wu, Y.,Li, G.-B.	((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-beta-lactamase inhibitors: Synthesis, kinetic and crystallographic studies.	Eur J Med Chem	2018	145	649	660	
5X1Q	29858276	PpkA-294 with ATP and MnCl2	2017-01-26	2018-01-31	Li, P.P.,Xu, D.Q.,Ma, T.Q.,Wang, D.Y.,Li, W.D.,He, J.H.,Ran, T.T.,Wang, W.W.	Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism.	Biochem.J.	2018	475	2209	2224	
5X1R	29858276	PpkA-294 apo form	2017-01-26	2018-01-31	Li, P.P.,Xu, D.Q.,Ma, T.Q.,Wang, D.Y.,Li, W.D.,He, J.H.,Ran, T.T.,Wang, W.W.	Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism.	Biochem.J.	2018	475	2209	2224	
5YK2	29350349	The complex structure of Rv3197-erythromycin from Mycobacterium tuberculosis	2017-10-11	2018-02-07	Zhang, Q.,Liu, H.,Liu, X.,Jiang, D.,Zhang, B.,Tian, H.,Yang, C.,Guddat, L.W.,Yang, H.,Mi, K.,Rao, Z.	Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target.	Protein Cell	2018	9	971	975	
5X2K	29568384	Crystal structure of EGFR 696-1022 T790M in complex with WZ4003	2017-02-01	2018-02-21	Zhu, S.J.,Zhao, P.,Yang, J.,Ma, R.,Yan, X.E.,Yang, S.Y.,Yang, J.W.,Yun, C.H.	Structural insights into drug development strategy targeting EGFR T790M/C797S.	Oncotarget	2018	9	13652	13665	
5X5R		Crystal structure of a hydrolase from Listeria innocua	2017-02-17	2018-02-21	Zhang, J.,Zhou, J.	Crystal structure of a hydrolase encoded by lin2189 from Listeria innocua	To Be Published	0	0	0	0	
5YPI	29269938	Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI1 complex	2017-11-01	2018-02-21	Feng, H.,Liu, X.,Wang, S.,Fleming, J.,Wang, D.C.,Liu, W.	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.	Nat Commun	2017	8	2242	2242	
5YPK	29269938	Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex	2017-11-02	2018-02-21	Feng, H.,Liu, X.,Wang, S.,Fleming, J.,Wang, D.C.,Liu, W.	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.	Nat Commun	2017	8	2242	2242	
5YPL	29269938	Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EP complex	2017-11-02	2018-02-21	Feng, H.,Liu, X.,Wang, S.,Fleming, J.,Wang, D.C.,Liu, W.	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.	Nat Commun	2017	8	2242	2242	
5Y92	29388293	Crystal structure of ANXUR2 extracellular domain from Arabidopsis thaliana	2017-08-22	2018-02-28	Du, S.,Qu, L.J.,Xiao, J.	Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2	Protein Sci.	2018	27	886	892	
5Y96	29388293	Crystal structure of ANXUR1 extracellular domain from Arabidopsis thaliana	2017-08-22	2018-02-28	Du, S.,Qu, L.J.,Xiao, J.	Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2	Protein Sci.	2018	27	886	892	
5YXH	29416044	Structure of Rheb-GDP	2017-12-05	2018-02-28	Mahoney, S.J.,Narayan, S.,Molz, L.,Berstler, L.A.,Kang, S.A.,Vlasuk, G.P.,Saiah, E.	A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.	Nat Commun	2018	9	548	548	
5XHH		crystal structure of Hcp1 from Salmonella typhimurium	2017-04-21	2018-03-07	Lin, Q.P.,Gao, Z.Q.,Zhang, H.,Dong, Y.H.	crystal structure of Hcp1 from Salmonella typhimurium	To Be Published	0	0	0	0	
5Z2L	29462616	Crystal structure of BdcA in complex with NADPH	2018-01-03	2018-03-07	Yang, W.S.,Hong, Y.,Zhang, Y.,Wang, D.C.,Li, D.F.,Hou, Y.J.	A potential substrate binding pocket of BdcA plays a critical role in NADPH recognition and biofilm dispersal	Biochem. Biophys. Res. Commun.	2018	497	863	868	
5N8S	29429875	Crystal Structure of Drosophila DHX36 helicase in complex with polyT	2017-02-24	2018-03-14	Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G.	Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.	Structure	2018	26	403	0	
5N90	29429875	Crystal Structure of Drosophila DHX36 helicase in complex with TTGTGGTGT	2017-02-24	2018-03-14	Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G.	Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.	Structure	2018	26	403	0	
5N94	29429875	Crystal Structure of Drosophila DHX36 helicase in complex with polyU	2017-02-24	2018-03-14	Chen, W.F.,Rety, S.,Guo, H.L.,Dai, Y.X.,Wu, W.Q.,Liu, N.N.,Auguin, D.,Liu, Q.W.,Hou, X.M.,Dou, S.X.,Xi, X.G.	Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.	Structure	2018	26	403	0	
5YGB	29531043	Crystal structure of drosophila melanogaster Papi extended Tudor domain mutant - D287A	2017-09-22	2018-03-14	Zhang, Y.,Liu, W.,Li, R.,Gu, J.,Wu, P.,Peng, C.,Ma, J.,Wu, L.,Yu, Y.,Huang, Y.	Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi	Proc. Natl. Acad. Sci. U.S.A.	2018	115	3374	3379	
5YGC	29531043	Crystal structure of Drosophila melanogaster Papi extended Tudor domain	2017-09-22	2018-03-14	Zhang, Y.,Liu, W.,Li, R.,Gu, J.,Wu, P.,Peng, C.,Ma, J.,Wu, L.,Yu, Y.,Huang, Y.	Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi	Proc. Natl. Acad. Sci. U.S.A.	2018	115	3374	3379	
5YGD	29531043	Crystal structure of Drosophila melanogaster Papi extended Tudor domain (D287A) in complex with Piwi N-terminal R10me2s peptide	2017-09-22	2018-03-14	Zhang, Y.,Liu, W.,Li, R.,Gu, J.,Wu, P.,Peng, C.,Ma, J.,Wu, L.,Yu, Y.,Huang, Y.	Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi	Proc. Natl. Acad. Sci. U.S.A.	2018	115	3374	3379	
5YGF	29531043	Crystal structure of Drosophila melanogaster Papi extended Tudor domain (D287A) in complex with Piwi N-terminal R10-unme peptide	2017-09-22	2018-03-14	Zhang, Y.,Liu, W.,Li, R.,Gu, J.,Wu, P.,Peng, C.,Ma, J.,Wu, L.,Yu, Y.,Huang, Y.	Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi	Proc. Natl. Acad. Sci. U.S.A.	2018	115	3374	3379	
5YPR	29281827	Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor	2017-11-02	2018-03-14	Zhu, J.,Zhou, Q.,Shang, Y.,Li, H.,Peng, M.,Ke, X.,Weng, Z.,Zhang, R.,Huang, X.,Li, S.S.C.,Feng, G.,Lu, Y.,Zhang, M.	Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.	Cell Rep	2017	21	3781	3793	
5YVT	29453450	Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with Mg(2+) and NADH	2017-11-27	2018-03-14	Liu, Y.,Hu, L.,Ma, T.,Yang, J.,Ding, J.	Insights into the inhibitory mechanisms of NADH on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.	Sci Rep	2018	8	3146	3146	
5YVX	29496997	Crystal structure of SDG8 CW domain in complex with H3K4me1 peptide	2017-11-27	2018-03-14	Liu, Y.,Huang, Y.	Uncovering the mechanistic basis for specific recognition of monomethylated H3K4 by the CW domain ofArabidopsishistone methyltransferase SDG8.	J. Biol. Chem.	2018	293	6470	6481	
5Z9S	29421652	Functional and Structural Characterization of a beta-Glucosidase Involved in Saponin Metabolism from Intestinal Bacteria	2018-02-05	2018-03-14	Yan, S.,Wei, P.C.,Chen, Q.,Chen, X.,Wang, S.C.,Li, J.R.,Gao, C.	Functional and structural characterization of a beta-glucosidase involved in saponin metabolism from intestinal bacteria.	Biochem. Biophys. Res. Commun.	2018	496	1349	1356	
5XBI	29967320	The structure of BrlR-C domain bound to 3-amino-2-phenazino(a pyocyanin analog)	2017-03-17	2018-03-21	Wang, F.,He, Q.,Yin, J.,Xu, S.,Hu, W.,Gu, L.	BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin.	Nat Commun	2018	9	2563	2563	
5YIX	29514271	Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70	2017-10-06	2018-03-21	Wu, X.,Haakonsen, D.L.,Sanderlin, A.G.,Liu, Y.J.,Shen, L.,Zhuang, N.,Laub, M.T.,Zhang, Y.	Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.	Nucleic Acids Res.	2018	46	3245	3256	
5Z8O	29512898	Structural of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis	2018-01-31	2018-03-21	Zheng, S.,Zhou, Y.,Fleming, J.,Zhou, Y.,Zhang, M.,Li, S.,Li, H.,Sun, B.,Liu, W.,Bi, L.	Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis.	FEBS Lett.	2018	592	1445	1457	
5XBV		Crystal structure of Wss1 mutant from saccharomyces cerevisiae	2017-03-21	2018-03-28	Dong, Y.H.,Yang, X.Y.,Wang, W.J.	crystal structure of Wss1 mutant from saccharomyces cerevisiae	To Be Published	0	0	0	0	
5YD0	29563550	Crystal structure of Schlafen 13 (SLFN13) N'-domain	2017-09-09	2018-03-28	Yang, J.Y.,Deng, X.Y.,Li, Y.S.,Ma, X.C.,Feng, J.X.,Yu, B.,Chen, Y.,Luo, Y.L.,Wang, X.,Chen, M.L.,Fang, Z.X.,Zheng, F.X.,Li, Y.P.,Zhong, Q.,Kang, T.B.,Song, L.B.,Xu, R.H.,Zeng, M.S.,Chen, W.,Zhang, H.,Xie, W.,Gao, S.	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control	Nat Commun	2018	9	1165	1165	
5YEP	29555683	Crystal structure of SO_3166-SO_3165 from Shewanella oneidensis	2017-09-19	2018-03-28	Jia, X.,Yao, J.,Gao, Z.,Liu, G.,Dong, Y.H.,Wang, X.,Zhang, H.	Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system.	J. Biol. Chem.	2018	293	6812	6823	
5Y8E	29549035	Crystal Structure of a prokaryotic SEFIR domain	2017-08-21	2018-04-04	Yang, H.,Zhu, Y.,Chen, X.,Li, X.,Ye, S.,Zhang, R.	Structure of a prokaryotic SEFIR domain reveals two novel SEFIR-SEFIR interaction modes.	J. Struct. Biol.	2018	203	81	89	
5XB6		Crystal structure of YcjY from E. Coli	2017-03-16	2018-04-11	Chen, C.F.,Gao, Z.Q.,Liu, Q.S.	Crystal structure of YcjY from E. Coli	To Be Published	0	0	0	0	
5XHZ	29589748	Crystal Structure Analysis of CIN85-SH3B in complex with ARAP1-P2	2017-04-25	2018-04-11	Li, Q.,Yang, W.,Wang, Y.,Liu, W.	Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85.	Biochemistry	2018	57	2132	2139	
5XOM	29572475	Hydra Fam20	2017-05-29	2018-04-11	Zhang, H.,Zhu, Q.,Cui, J.,Wang, Y.,Chen, M.J.,Guo, X.,Tagliabracci, V.S.,Dixon, J.E.,Xiao, J.	Structure and evolution of the Fam20 kinases	Nat Commun	2018	9	1218	1218	
5YH0	29572475	The structure of DrFam20C1	2017-09-27	2018-04-11	Zhang, H.,Zhu, Q.,Cui, J.,Wang, Y.,Chen, M.J.,Guo, X.,Tagliabracci, V.S.,Dixon, J.E.,Xiao, J.	Structure and evolution of the Fam20 kinases	Nat Commun	2018	9	1218	1218	
5YLJ	29691282	Crystal structure of T2R-TTL-Millepachine complex	2017-10-17	2018-04-11	Yang, J.H.,Yan, W.,Yu, Y.M.,Wang, Y.X.,Yang, T.,Xue, L.L.,Yuan, X.,Long, C.F.,Liu, Z.W.,Chen, X.X.,Hu, M.S.,Zheng, L.,Qiu, Q.,Pei, H.Y.,Li, D.,Wang, F.,Bai, P.,Wen, J.L.,Ye, H.Y.,Chen, L.J.	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.	J. Biol. Chem.	2018	293	9461	9472	
5YLS	29691282	Crystal structure of T2R-TTL-Y50 complex	2017-10-18	2018-04-11	Yang, J.H.,Yan, W.,Yu, Y.M.,Wang, Y.X.,Yang, T.,Xue, L.L.,Yuan, X.,Long, C.F.,Liu, Z.W.,Chen, X.X.,Hu, M.S.,Zheng, L.,Qiu, Q.,Pei, H.Y.,Li, D.,Wang, F.,Bai, P.,Wen, J.L.,Ye, H.Y.,Chen, L.J.	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.	J. Biol. Chem.	2018	293	9461	9472	
5Z9Y	29428731	Crystal structure of Mycobacterium tuberculosis thiazole synthase (ThiG) complexed with DXP	2018-02-05	2018-04-11	Zhang, J.,Zhang, B.,Zhao, Y.,Yang, X.,Huang, M.,Cui, P.,Zhang, W.,Li, J.,Zhang, Y.	Snapshots of catalysis: Structure of covalently bound substrate trapped in Mycobacterium tuberculosis thiazole synthase (ThiG).	Biochem. Biophys. Res. Commun.	2018	497	214	219	
5ZHO	29593033	Human group C rotavirus VP8*s recognize type A histo-blood group antigens as ligands	2018-03-13	2018-04-11	Sun, X.,Wang, L.,Qi, J.,Li, D.,Wang, M.,Cong, X.,Peng, R.,Chai, W.,Zhang, Q.,Wang, H.,Wen, H.,Gao, G.F.,Tan, M.,Duan, Z.	Human Group C Rotavirus VP8*s Recognize Type A Histo-Blood Group Antigens as Ligands.	J. Virol.	2018	92	0	0	
5XIW	29691282	Crystal structure of T2R-TTL-Colchicine complex	2017-04-27	2018-04-18	Jianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C.	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.	J. Biol. Chem.	2018	0	0	0	
5XKF		Crystal structure of T2R-TTL-MPC6827 complex	2017-05-07	2018-04-18	Yan, W.,Yang, J.	Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors	To Be Published	0	0	0	0	
5XKG		Crystal structure of T2R-TTL-CH1 complex	2017-05-07	2018-04-18	Yan, W.,Yang, J.	Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors	To Be Published	0	0	0	0	
5YL2	29691282	Crystal structure of T2R-TTL-Y28 complex	2017-10-16	2018-04-18	Jianhong, Y.,Wei, Y.,Yamei, Y.,Yuxi, W.,Tao, Y.,Linlin, X.,Xue, Y.,Caofeng, L.,Zuowei, L.,Xiaoxin, C.,Mengshi, H.,Li, Z.,Qiang, Q.,Heying, P.,Dan, L.,Fang, W.,Peng, B.,Jiaolin, W.,Haoyu, Y.,Lijuan, C.	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.	J. Biol. Chem.	2018	0	0	0	
5ZCK	29681455	Structure of the RIP3 core region	2018-02-18	2018-04-18	Mompean, M.,Li, W.,Li, J.,Laage, S.,Siemer, A.B.,Bozkurt, G.,Wu, H.,McDermott, A.E.	The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.	Cell	2018	173	1244	0	
5XGH	29109464	Crystal structure of PI3K complex with an inhibitor	2017-04-13	2018-04-25	Yang, X.,Zhang, X.,Huang, M.,Song, K.,Li, X.,Huang, M.,Meng, L.,Zhang, J.	New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound.	Sci Rep	2017	7	14572	14572	
5XGI		Crystal structure of PI3K complex with an inhibitor	2017-04-13	2018-04-25	Song, K.,Yang, X.,Zhao, Y.,Jian, Z.	Crystal structure of PI3K complex with an inhibitor	To Be Published	0	0	0	0	
5XGJ		Crystal structure of PI3K complex with an inhibitor	2017-04-13	2018-04-25	Song, K.,Yang, X.,Zhao, Y.,Jian, Z.	Crystal structure of PI3K complex with an inhibitor	To Be Published	0	0	0	0	
5XGV	29657086	The structure of Diels-Alderase PyrE3 in the biosynthetic pathway of pyrroindomycins	2017-04-18	2018-04-25	Zheng, Q.,Gong, Y.,Guo, Y.,Zhao, Z.,Wu, Z.,Zhou, Z.,Chen, D.,Pan, L.,Liu, W.	Structural Insights into a Flavin-Dependent [4 + 2] Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis.	Cell Chem Biol	2018	25	718	0	
5XHS		Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA	2017-04-24	2018-05-02	Wang, H.L.,Liu, S.,Yu, Z.J.,Wu, C.,Cheng, L.,Wang, Y.,Chen, K.,Zhou, S.,Chen, Q.,Yu, Y.,Li, G.B.	Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design	Rsc Adv	2017	7	36214	36222	
5XUO	29761048	Pks13 AT domain fragment from Mycobacterium tuberculosis	2017-06-24	2018-05-02	Yu, M.,Dou, C.,Gu, Y.,Cheng, W.	Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain fromMycobacterium tuberculosis	PeerJ	2018	6	0	0	
5YUG		AtVAL1 PHD-Like domain in the P31 space group	2017-11-22	2018-05-02	Zhang, M.M.,Wu, B.X.	AtVAL1 PHD-Like domain in the P31 space group	To Be Published	0	0	0	0	
5YUH		AtVAL1 PHD-Like domain in the P6122 space group	2017-11-22	2018-05-02	Zhang, M.M.,Wu, B.X.	AtVAL1 PHD-Like domain in the P6122 space group	To Be Published	0	0	0	0	
5YRP	29555845	Crystal structure of the EAL domain of Mycobacterium smegmatis DcpA	2017-11-09	2018-05-09	Chen, H.J.,Li, N.,Luo, Y.,Jiang, Y.L.,Zhou, C.Z.,Chen, Y.,Li, Q.	The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis.	Biochem. J.	2018	475	1295	1308	
5XKA	28712808	Crystal structure of M.tuberculosis PknI kinase domain	2017-05-06	2018-05-16	Yan, Q.,Jiang, D.,Qian, L.,Zhang, Q.,Zhang, W.,Zhou, W.,Mi, K.,Guddat, L.,Yang, H.,Rao, Z.	Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain.	Structure	2017	25	1286	0	
5XKV	28795725	structure of sperm whale myoglobin F138W	2017-05-09	2018-05-16	Li, L.L.,Yuan, H.,Liao, F.,He, B.,Gao, S.Q.,Wen, G.B.,Tan, X.,Lin, Y.W.	Rational design of artificial dye-decolorizing peroxidases using myoglobin by engineering Tyr/Trp in the heme center	Dalton Trans	2017	46	11230	11238	
5XKW	28795725	myoglobin mutant F43Y/F46Y	2017-05-09	2018-05-16	Li, L.L.,Yuan, H.,Liao, F.,He, B.,Gao, S.Q.,Wen, G.B.,Tan, X.,Lin, Y.W.	Rational design of artificial dye-decolorizing peroxidases using myoglobin by engineering Tyr/Trp in the heme center	Dalton Trans	2017	46	11230	11238	
5XM2	30528735	Human N-terminal domain of FACT complex subunit SPT16	2017-05-12	2018-05-16	Jiang, H.,Xu, S.,Chen, Y.,Li, H.,Tian, L.,Zhou, H.,Zhao, Z.,Yang, C.,Zhong, Z.,Cai, G.,Su, D.	The structural basis of human Spt16 N-terminal domain interaction with histone (H3-H4)2tetramer.	Biochem.Biophys.Res.Commun.	2019	508	864	870	
5XMG	28758353	Crystal structure of PA3488 from Pseudomonas aeruginosa	2017-05-15	2018-05-16	Yang, X.Y.,Li, Z.Q.,Gao, Z.Q.,Wang, W.J.,Geng, Z.,Xu, J.H.,She, Z.,Dong, Y.H.	Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa.	Protein Sci.	2017	26	2083	2091	
5Y9O	29701815	The apo structure of Legionella pneumophila WipA	2017-08-26	2018-05-16	Jia, Q.,Lin, Y.,Gou, X.,He, L.,Shen, D.,Chen, D.,Xie, W.,Lu, Y.	Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity	Acta Biochim. Biophys. Sin. (S	2018	50	547	554	
5XOH		Crystal structure of bergaptol o-methyltransferase complex	2017-05-28	2018-05-23	Zhou, Y.,Zeng, Z.	Crystal structure of bergaptol o-methyltransferase complex	To Be Published	0	0	0	0	
5YDA	29536601	The crystal structure of the Acyl Transferase domain of SpnD	2017-09-12	2018-05-23	Li, Y.,Zhang, W.,Zhang, H.,Tian, W.Y.,Wu, L.,Wang, S.W.,Zheng, M.M.,Zhang, J.R.,Sun, C.H.,Deng, Z.X.,Sun, Y.H.,Qu, X.D.,Zhou, J.H.	Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.	Angew. Chem. Int. Ed. Engl.	2018	57	5823	5827	
5YDL	29536601	The crystal structure of the Acyl Transferase domain of SpnD complex with 2-(pent-4-yn-1-yl)malonyl	2017-09-13	2018-05-23	Li, Y.,Zhang, W.,Zhang, H.,Tian, W.Y.,Wu, L.,Wang, S.W.,Zheng, M.M.,Zhang, J.R.,Sun, C.H.,Deng, Z.X.,Sun, Y.H.,Qu, X.D.,Zhou, J.H.	Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.	Angew. Chem. Int. Ed. Engl.	2018	57	5823	5827	
5YDM	29536601	The crystal structure of the Acyl Transferase domain of SpnD complex with benzylmalonyl	2017-09-13	2018-05-23	Li, Y.,Zhang, W.,Zhang, H.,Tian, W.Y.,Wu, L.,Wang, S.W.,Zheng, M.M.,Zhang, J.R.,Sun, C.H.,Deng, Z.X.,Sun, Y.H.,Qu, X.D.,Zhou, J.H.	Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.	Angew. Chem. Int. Ed. Engl.	2018	57	5823	5827	
5YIP	29867141	Crystal Structure of AnkG LIR/GABARAPL1 complex	2017-10-06	2018-05-23	Li, J.,Zhu, R.,Chen, K.,Zheng, H.,Zhao, H.,Yuan, C.,Zhang, H.,Wang, C.,Zhang, M.	Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.	Nat. Chem. Biol.	2018	14	778	787	
5YIR	29867141	Crystal Structure of AnkB LIR/GABARAP complex	2017-10-06	2018-05-23	Li, J.,Zhu, R.,Chen, K.,Zheng, H.,Zhao, H.,Yuan, C.,Zhang, H.,Wang, C.,Zhang, M.	Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.	Nat. Chem. Biol.	2018	14	778	787	
5YJG	29754429	Structural insights into periostin functions	2017-10-10	2018-05-23	Liu, J.,Zhang, J.,Xu, F.,Lin, Z.,Li, Z.,Liu, H.	Structural characterizations of human periostin dimerization and cysteinylation.	FEBS Lett.	2018	592	1789	1803	
5YJH	29754429	Structural insights into periostin functions	2017-10-10	2018-05-23	Liu, J.,Zhang, J.,Xu, F.,Lin, Z.,Li, Z.,Liu, H.	Structural characterizations of human periostin dimerization and cysteinylation.	FEBS Lett.	2018	592	1789	1803	
5ZQ7	29731171	SidE-Ubi-NAD	2018-04-17	2018-05-23	Wang, Y.,Shi, M.,Feng, H.,Zhu, Y.,Liu, S.,Gao, A.,Gao, P.	Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE.	Cell	2018	173	1231	0	
5XNI		Crystal structure of Microcystis aeruginosa PCC 7806 aspartate/glutamate racemase in complex with D-glutamate	2017-05-23	2018-05-30	Cao, D.D.,Zhou, C.Z.	Structure-function Analyses of a Cyanobacterial Aspartate/Glutamate Racemase Reveal Its Catalytic Mechanism and Substrate Specificity	To Be Published	0	0	0	0	
5XNJ		Crystal structure of Microcystis aeruginosa PCC 7806 aspartate/glutamate racemase in complex with L-glutamate	2017-05-23	2018-05-30	Cao, D.D.,Zhou, C.Z.	Structure-function Analyses of a Cyanobacterial Aspartate/Glutamate Racemase Reveal Its Catalytic Mechanism and Substrate Specificity	To Be Published	0	0	0	0	
5XNK		Crystal structure of Microcystis aeruginosa PCC 7806 aspartate racemase in complex with DL-methyl-aspartate	2017-05-23	2018-05-30	Cao, D.D.,Zhou, C.Z.	Structure-function Analyses of a Cyanobacterial Aspartate Racemase Reveal Its Catalytic Mechanism and Substrate Specificity	To Be Published	0	0	0	0	
5Y18	28875424	Crystal structure of DAXX helical bundle domain in complex with ATRX	2017-07-19	2018-05-30	Wang, X.,Zhao, Y.,Zhang, J.,Chen, Y.	Structural basis for DAXX interaction with ATRX	Protein Cell	2017	8	767	771	
5Y45	29376320	Crystal structure of a collagen-like peptide with interruption sequence	2017-08-01	2018-05-30	Xu, T.,Zhou, C.Z.,Xiao, J.,Liu, J.	Unique Conformation in a Natural Interruption Sequence of Type XIX Collagen Revealed by Its High-Resolution Crystal Structure.	Biochemistry	2018	57	1087	1095	
5Y46	29376320	Crystal structure of a collagen-like peptide with interruption sequence	2017-08-01	2018-05-30	Xu, T.,Zhou, C.Z.,Xiao, J.,Liu, J.	Unique Conformation in a Natural Interruption Sequence of Type XIX Collagen Revealed by Its High-Resolution Crystal Structure.	Biochemistry	2018	57	1087	1095	
5YZ2	29453981	the cystathionine-beta-synthase (CBS) domain of magnesium and cobalt efflux protein CorC in complex with both C2'- and C3'-endo AMP	2017-12-12	2018-05-30	Feng, N.,Qi, C.,Hou, Y.J.,Zhang, Y.,Wang, D.C.,Li, D.F.	The C2'- and C3'-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain.	Biochem. Biophys. Res. Commun.	2018	497	646	651	
5XWV	29626512	Substrate-bound Structure of a Ketoreductase from the Second Module of the amphotericin Polyketide Synthases	2017-06-30	2018-06-06	Liu, C.,Yuan, M.,Xu, X.,Wang, L.,Keatinge-Clay, A.T.,Deng, Z.,Lin, S.,Zheng, J.	Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.	J. Struct. Biol.	2018	203	135	141	
5Y0F	29775936	Crystal structure of human FABP4 complexed with ligand 2-fluoro-5-((4-methoxynaphthalene)-1-sulfonamido) benzoic acid	2017-07-17	2018-06-06	Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X.	From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4	Eur J Med Chem	2018	154	44	59	
5Y0G	29775936	Crystal structure of human FABP4 complexed with ligand 4-Fluoro-3-((4-methoxynaphthalene)-1-sulfonamido) benzoic acid	2017-07-17	2018-06-06	Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X.	From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4	Eur J Med Chem	2018	154	44	59	
5Y0X	29775936	Crystal structure of human FABP4 complexed with ligand 2-fluoro-3-((4-methoxynaphthalene)-1-sulfonamido)benzoic acid	2017-07-19	2018-06-06	Gao, D.D.,Dou, H.X.,Su, H.X.,Zhang, M.M.,Wang, T.,Liu, Q.F.,Cai, H.Y.,Ding, H.P.,Yang, Z.,Zhu, W.L.,Xu, Y.C.,Wang, H.Y.,Li, Y.X.	From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4	Eur J Med Chem	2018	154	44	59	
5Y8C	29566488	Crystal Structure Analysis of the BRD4	2017-08-21	2018-06-13	Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.	Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)	J. Med. Chem.	2018	61	3037	3058	
5Y8Y	29566488	Crystal Structure Analysis of the BRD4	2017-08-21	2018-06-13	Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.	Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)	J. Med. Chem.	2018	61	3037	3058	
5Y8Z	29566488	Crystal Structure Analysis of the BRD4	2017-08-22	2018-06-13	Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.	Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)	J. Med. Chem.	2018	61	3037	3058	
5Y93	29566488	Crystal Structure Analysis of the BRD4	2017-08-22	2018-06-13	Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.	Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)	J. Med. Chem.	2018	61	3037	3058	
5Y94	29566488	Crystal Structure Analysis of the BRD4	2017-08-22	2018-06-13	Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.	Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)	J. Med. Chem.	2018	61	3037	3058	
5XKH		Crystal structure of T2R-TTL-CF1 complex	2017-05-07	2018-06-20	Yan, W.,Yang, J.	Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors	To Be Published	0	0	0	0	
5XYW	29858487	Crystal structure of drosophila simulans Rhino chromoshadow domain in complex with N-terminal domain	2017-07-10	2018-06-20	Yu, B.,Lin, Y.A.,Parhad, S.S.,Jin, Z.,Ma, J.,Theurkauf, W.E.,Zhang, Z.Z.,Huang, Y.	Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification	EMBO Rep.	2018	19	0	0	
5YET	30428313	Structure of R354_WT	2017-09-19	2018-06-20	Dou, C.,Yu, M.,Gu, Y.,Wang, J.,Yin, K.,Nie, C.,Zhu, X.,Qi, S.,Wei, Y.,Cheng, W.	Structural and Mechanistic Analyses Reveal a Unique Cas4-like Protein in the Mimivirus Virophage Resistance Element System.	Iscience	2018	3	1	10	
5ZU6	29864445	A CBM32 derived from alginate lyase B (AlyB-OU02)	2018-05-07	2018-06-20	Lyu, Q.,Zhang, K.,Zhu, Q.,Li, Z.,Liu, Y.,Fitzek, E.,Yohe, T.,Zhao, L.,Li, W.,Liu, T.,Yin, Y.,Liu, W.	Structural and biochemical characterization of a multidomain alginate lyase reveals a novel role of CBM32 in CAZymes	Biochim. Biophys. Acta	2018	1862	1862	1869	
5XUG	29550433	Complex structure(RmMan134A-M5).	2017-06-23	2018-06-27	You, X.,Qin, Z.,Li, Y.X.,Yan, Q.J.,Li, B.,Jiang, Z.Q.	Structural and biochemical insights into the substrate-binding mechanism of a novel glycoside hydrolase family 134 beta-mannanase.	Biochim Biophys Acta Gen Subj	2018	1862	1376	1388	
5ZU5	29864445	Crystal structure of a full length alginate lyase with CBM domain	2018-05-07	2018-06-27	Lyu, Q.,Zhang, K.,Zhu, Q.,Li, Z.,Liu, Y.,Fitzek, E.,Yohe, T.,Zhao, L.,Li, W.,Liu, T.,Yin, Y.,Liu, W.	Structural and biochemical characterization of a multidomain alginate lyase reveals a novel role of CBM32 in CAZymes	Biochim. Biophys. Acta	2018	1862	1862	1869	
6BR1	29406710	Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a	2017-11-29	2018-06-27	Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.	Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.	J. Med. Chem.	2018	61	1704	1718	
6BRF	29406710	Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4b	2017-11-30	2018-06-27	Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.	Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.	J. Med. Chem.	2018	61	1704	1718	
6BRY	29406710	Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 6a	2017-12-01	2018-06-27	Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.	Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.	J. Med. Chem.	2018	61	1704	1718	
6BS2	29406710	Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 8b	2017-12-01	2018-06-27	Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.	Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.	J. Med. Chem.	2018	61	1704	1718	
5X16		Sirt6 apo structure	2017-01-24	2018-07-04	Zhang, J.,Huang, Z.,Song, K.	Sirt6 apo structure	To Be Published	0	0	0	0	
5XJQ	31799625	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2/F/E/G from Human	2017-05-04	2018-07-04	Yi, H.,Mu, L.,Shen, C.,Kong, X.,Wang, Y.,Hou, Y.,Zhang, R.	Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.	Nucleic Acids Res.	2019	0	0	0	
5XJR	31799625	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E/G from Human	2017-05-04	2018-07-04	Yi, H.,Mu, L.,Shen, C.,Kong, X.,Wang, Y.,Hou, Y.,Zhang, R.	Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.	Nucleic Acids Res.	2019	0	0	0	
5XJS	31799625	Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E from Human	2017-05-04	2018-07-04	Yi, H.,Mu, L.,Shen, C.,Kong, X.,Wang, Y.,Hou, Y.,Zhang, R.	Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.	Nucleic Acids Res.	2019	0	0	0	
5XJU		Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2.R61A/F/E/G from Human	2017-05-04	2018-07-04	Yi, H.,Zhang, R.	Structures of 7S mutant complexes.	To Be Published	0	0	0	0	
5XKE		Crystal structure of T2R-TTL-Demecolcine complex	2017-05-07	2018-07-04	Yan, W.,Yang, J.	Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors	To Be Published	0	0	0	0	
5XVJ	30176245	Crystal structure of AL7 PAL domain	2017-06-28	2018-07-04	Peng, L.,Wang, L.,Zhang, Y.,Dong, A.,Shen, W.H.,Huang, Y.	Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch	J. Mol. Biol.	2018	430	4245	4259	
5XVL	30176245	Crystal structure of AL2 PAL domain	2017-06-28	2018-07-04	Peng, L.,Wang, L.,Zhang, Y.,Dong, A.,Shen, W.H.,Huang, Y.	Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch	J. Mol. Biol.	2018	430	4245	4259	
5XVW	30176245	Crystal structure of AL2 PAL domain in complex with AtRing1a distal site	2017-06-28	2018-07-04	Peng, L.,Wang, L.,Zhang, Y.,Dong, A.,Shen, W.H.,Huang, Y.	Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch	J. Mol. Biol.	2018	430	4245	4259	
5YSM	29904078	Crystal Structure Analysis of Rif16	2017-11-14	2018-07-04	Qi, F.,Lei, C.,Li, F.,Zhang, X.,Wang, J.,Zhang, W.,Fan, Z.,Li, W.,Tang, G.L.,Xiao, Y.,Zhao, G.,Li, S.	Deciphering the late steps of rifamycin biosynthesis.	Nat Commun	2018	9	2342	2342	
5YSW	29904078	Crystal Structure Analysis of Rif16 in complex with R-L	2017-11-15	2018-07-04	Qi, F.,Lei, C.,Li, F.,Zhang, X.,Wang, J.,Zhang, W.,Fan, Z.,Li, W.,Tang, G.L.,Xiao, Y.,Zhao, G.,Li, S.	Deciphering the late steps of rifamycin biosynthesis.	Nat Commun	2018	9	2342	2342	
5Z12	29934308	A structure of FXR/RXR	2017-12-23	2018-07-04	Zheng, W.,Lu, Y.,Tian, S.,Ma, F.,Wei, Y.,Xu, S.,Li, Y.	Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR	J. Biol. Chem.	2018	293	12535	12541	
5ZUE	29889022	GTP-bound, double-stranded, curved FtsZ protofilament structure	2018-05-07	2018-07-04	Guan, F.,Yu, J.,Yu, J.,Liu, Y.,Li, Y.,Feng, X.H.,Huang, K.C.,Chang, Z.,Ye, S.	Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division	Elife	2018	7	0	0	
5WXR		Crystal structure of uPA in complex with upain-2-4-W3A	2017-01-08	2018-07-11	Jiang, L.,Huang, M.	Crystal structure of uPA in complex with upain-2-4-W3A	To Be Published	0	0	0	0	
5YT6	29940186	Crystal structure of TAX1BP1 UBZ2 in complex with mono-ubiquitin	2017-11-17	2018-07-11	Hu, S.,Wang, Y.,Gong, Y.,Liu, J.,Li, Y.,Pan, L.	Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1.	J. Mol. Biol.	2018	430	3283	3296	
5ZE4	29995859	The structure of holo- structure of DHAD complex with [2Fe-2S] cluster	2018-02-26	2018-07-18	Yan, Y.,Liu, Q.,Zang, X.,Yuan, S.,Bat-Erdene, U.,Nguyen, C.,Gan, J.,Zhou, J.,Jacobsen, S.E.,Tang, Y.	Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.	Nature	2018	559	415	418	
5ZNP	29930355	Crystal structure of PtSHL in complex with an H3K4me3 peptide	2018-04-10	2018-07-18	Qian, S.,Lv, X.,Scheid, R.N.,Lu, L.,Yang, Z.,Chen, W.,Liu, R.,Boersma, M.D.,Denu, J.M.,Zhong, X.,Du, J.	Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.	Nat Commun	2018	9	2425	2425	
5ZNR	29930355	Crystal structure of PtSHL in complex with an H3K27me3 peptide	2018-04-10	2018-07-18	Qian, S.,Lv, X.,Scheid, R.N.,Lu, L.,Yang, Z.,Chen, W.,Liu, R.,Boersma, M.D.,Denu, J.M.,Zhong, X.,Du, J.	Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.	Nat Commun	2018	9	2425	2425	
5Y21	30176245	Crystal structure of AL2 PAL domain in complex with AtRing1a proximal site	2017-07-22	2018-07-25	Peng, L.,Wang, L.,Zhang, Y.,Dong, A.,Shen, W.H.,Huang, Y.	Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch	J. Mol. Biol.	2018	430	4245	4259	
5YE8	29193967	The crystal structure of Lp-PLA2 in complex with a novel inhibitor	2017-09-15	2018-07-25	Liu, Q.,Huang, F.,Yuan, X.,Wang, K.,Zou, Y.,Shen, J.,Xu, Y.	Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2.	J. Med. Chem.	2017	60	10231	10244	
5YEU	30428313	Structural and mechanistic analyses reveal a unique Cas4-like protein in the mimivirus virophage resistance element system	2017-09-19	2018-07-25	Dou, C.,Yu, M.,Gu, Y.,Wang, J.,Yin, K.,Nie, C.,Zhu, X.,Qi, S.,Wei, Y.,Cheng, W.	Structural and Mechanistic Analyses Reveal a Unique Cas4-like Protein in the Mimivirus Virophage Resistance Element System.	Iscience	2018	3	1	10	
5Z8L	30082787	crystal structure of Arabidopsis thaliana EBS in complex with an H3K27me3 peptide	2018-01-31	2018-07-25	Yang, Z.,Qian, S.,Scheid, R.N.,Lu, L.,Chen, X.,Liu, R.,Du, X.,Lv, X.,Boersma, M.D.,Scalf, M.,Smith, L.M.,Denu, J.M.,Du, J.,Zhong, X.	EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.	Nat. Genet.	2018	50	1247	1253	
5ZBA	30057113	Crystal structure of Rtt109-Asf1-H3-H4-CoA complex	2018-02-10	2018-07-25	Zhang, L.,Serra-Cardona, A.,Zhou, H.,Wang, M.,Yang, N.,Zhang, Z.,Xu, R.M.	Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.	Cell	2018	174	818	0	
5ZWJ	29802850	Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045	2018-05-15	2018-07-25	Zhao, P.,Yao, M.Y.,Zhu, S.J.,Chen, J.Y.,Yun, C.H.	Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045.	Biochem. Biophys. Res. Commun.	2018	502	332	337	
5ZGM	29969026	Crystal Structure of Parvalbumin SPVI, the Major Allergens in Mustelus griseus	2018-03-09	2018-08-01	Yang, R.Q.,Chen, Y.L.,Chen, F.,Wang, H.,Zhang, Q.,Liu, G.M.,Jin, T.,Cao, M.J.	Purification, Characterization, and Crystal Structure of Parvalbumins, the Major Allergens in Mustelus griseus.	J. Agric. Food Chem.	2018	66	8150	8159	
5ZH6	29969026	Crystal structure of Parvalbumin SPV-II of Mustelus griseus	2018-03-11	2018-08-01	Yang, R.Q.,Chen, Y.L.,Chen, F.,Wang, H.,Zhang, Q.,Liu, G.M.,Jin, T.,Cao, M.J.	Purification, Characterization, and Crystal Structure of Parvalbumins, the Major Allergens in Mustelus griseus.	J. Agric. Food Chem.	2018	66	8150	8159	
5Y0E		Crystal structure of TssK	2017-07-17	2018-08-08	Xu, D.,Tong, H.,Ran, T.,Wang, W.W.	Structure of TssK at 2.5 Angstroms resolution.	To Be Published	0	0	0	0	
5Y4M	30337146	Discoidin domain of human CASPR2	2017-08-04	2018-08-08	Liang, W.,Zhang, J.,Saint-Martin, M.,Xu, F.,Noraz, N.,Liu, J.,Honnorat, J.,Liu, H.	Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.	J. Autoimmun.	2019	96	168	177	
5Y53	30176245	Crystal structure of AL2 PAL domain in complex with AtBMI1b binding site	2017-08-07	2018-08-15	Peng, L.,Wang, L.,Zhang, Y.,Dong, A.,Shen, W.H.,Huang, Y.	Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch	J. Mol. Biol.	2018	430	4245	4259	
5Y5V		Crystal structure of a novel Pyrethroid Hydrolase PytH (S78A)	2017-08-09	2018-08-15	Xu, D.Q.,Gao, Y.Y.,Ran, T.T.,Zeng, L.P.,He, J.,Wang, W.W.	Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2	To Be Published	0	0	0	0	
5YF4	30072378	A kinase complex MST4-MOB4	2017-09-20	2018-08-15	Chen, M.,Zhang, H.,Shi, Z.,Li, Y.,Zhang, X.,Gao, Z.,Zhou, L.,Ma, J.,Xu, Q.,Guan, J.,Cheng, Y.,Jiao, S.,Zhou, Z.C.	The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.	J. Biol. Chem.	2018	293	14455	14469	
5YLO	30052139	Structural of Pseudomonas aeruginosa PA4980	2017-10-18	2018-08-22	Liu, L.,Li, T.,Peng, C.T.,Sun, C.Z.,Li, C.C.,Xiao, Q.J.,He, L.H.,Wang, N.Y.,Song, Y.J.,Zhu, Y.B.,Li, H.,Kang, M.,Tang, H.,Xiong, X.,Bao, R.	Structural characterization of a Delta3, Delta2-enoyl-CoA isomerase from Pseudomonas aeruginosa: implications for its involvement in unsaturated fatty acid metabolism.	J.Biomol.Struct.Dyn.	2019	37	2695	2702	
5YVD	30135128	Structural and biochemical characterization of endoribonuclease Nsp15 encoded by Middle East Respiratory Syndrome Coronavirus	2017-11-24	2018-08-22	Zhang, L.,Li, L.,Yan, L.,Ming, Z.,Jia, Z.,Lou, Z.,Rao, Z.	Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus.	J. Virol.	2018	92	0	0	
5Z2C	30111836	Crystal structure of ALPK-1 N-terminal domain in complex with ADP-heptose	2018-01-02	2018-08-22	Zhou, P.,She, Y.,Dong, N.,Li, P.,He, H.,Borio, A.,Wu, Q.,Lu, S.,Ding, X.,Cao, Y.,Xu, Y.,Gao, W.,Dong, M.,Ding, J.,Wang, D.C.,Zamyatina, A.,Shao, F.	Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.	Nature	2018	561	122	126	
5ZGF	30150473	Crystal structure of NDM-1 Q123G mutant	2018-03-08	2018-08-22	Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q.	Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.	Antimicrob. Agents Chemother.	2018	62	0	0	
5ZW5	30323253	Structure of SeMet-spAimR	2018-05-14	2018-08-29	Dou, C.,Xiong, J.,Gu, Y.,Yin, K.,Wang, J.,Hu, Y.,Zhou, D.,Fu, X.,Qi, S.,Zhu, X.,Yao, S.,Xu, H.,Nie, C.,Liang, Z.,Yang, S.,Wei, Y.,Cheng, W.	Structural and functional insights into the regulation of the lysis-lysogeny decision in viral communities.	Nat Microbiol	2018	3	1285	1294	
6A5N	30150382	Crystal structure of Arabidopsis thaliana SUVH6 in complex with methylated DNA	2018-06-24	2018-08-29	Li, X.,Harris, C.J.,Zhong, Z.,Chen, W.,Liu, R.,Jia, B.,Wang, Z.,Li, S.,Jacobsen, S.E.,Du, J.	Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.	Proc. Natl. Acad. Sci. U.S.A.	2018	115	0	0	
5Y6Y		The crystal structure of VrEH2 mutant M263N	2017-08-15	2018-09-05	Li, F.L.,Kong, X.D.,Chen, Q.,Zheng, Y.C.,Xu, Q.,Chen, F.F.,Fan, L.Q.,Lin, G.Q.,Zhou, J.H.,Yu, H.L.,Xu, J.H.	Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation	Acs Catalysis	2018	8	8314	8317	
5YB5		The complex crystal structure of VrEH2 mutant M263N with SNO	2017-09-03	2018-09-05	Li, F.L.,Kong, X.D.,Chen, Q.,Zheng, Y.C.,Xu, Q.,Chen, F.F.,Fan, L.Q.,Lin, G.Q.,Zhou, J.H.,Yu, H.L.,Xu, J.H.	Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation	Acs Catalysis	2018	8	8314	8317	
5ZVV	30323253	Structure of SeMet-phAimR	2018-05-13	2018-09-05	Dou, C.,Xiong, J.,Gu, Y.,Yin, K.,Wang, J.,Hu, Y.,Zhou, D.,Fu, X.,Qi, S.,Zhu, X.,Yao, S.,Xu, H.,Nie, C.,Liang, Z.,Yang, S.,Wei, Y.,Cheng, W.	Structural and functional insights into the regulation of the lysis-lysogeny decision in viral communities.	Nat Microbiol	2018	3	1285	1294	
5ZVW	30323253	Structure of phAimR-Ligand	2018-05-13	2018-09-05	Dou, C.,Xiong, J.,Gu, Y.,Yin, K.,Wang, J.,Hu, Y.,Zhou, D.,Fu, X.,Qi, S.,Zhu, X.,Yao, S.,Xu, H.,Nie, C.,Liang, Z.,Yang, S.,Wei, Y.,Cheng, W.	Structural and functional insights into the regulation of the lysis-lysogeny decision in viral communities.	Nat Microbiol	2018	3	1285	1294	
5ZW6	30323253	Structure of spAimR	2018-05-14	2018-09-05	Dou, C.,Xiong, J.,Gu, Y.,Yin, K.,Wang, J.,Hu, Y.,Zhou, D.,Fu, X.,Qi, S.,Zhu, X.,Yao, S.,Xu, H.,Nie, C.,Liang, Z.,Yang, S.,Wei, Y.,Cheng, W.	Structural and functional insights into the regulation of the lysis-lysogeny decision in viral communities.	Nat Microbiol	2018	3	1285	1294	
6ADI	30131249	Crystal Structures of IDH2 R140Q in complex with AG-881	2018-08-01	2018-09-05	Ma, R.,Yun, C.H.	Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2	Biochem. Biophys. Res. Commun.	2018	503	2912	2917	
6D88	30122035	Tubulin-RB3_SLD-TTL in complex with compound 13f	2018-04-26	2018-09-12	Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,Chen, H.,Wu, Z.,Yang, J.,White, S.W.,Miller, D.D.,Li, W.	Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.	J. Med. Chem.	2018	61	7877	7891	
6HEG	30190128	Crystal structure of Escherichia coli DEAH/RHA helicase HrpB	2018-08-20	2018-09-12	Xin, B.G.,Chen, W.F.,Rety, S.,Dai, Y.X.,Xi, X.G.	Crystal structure of Escherichia coli DEAH/RHA helicase HrpB.	Biochem. Biophys. Res. Commun.	2018	504	334	339	
5YBX	30503780	Crystal structure of the N-terminal domain of Bqt4 in S.pombe	2017-09-05	2018-09-19	Hu, C.,Inoue, H.,Sun, W.,Takeshita, Y.,Huang, Y.,Xu, Y.,Kanoh, J.,Chen, Y.	The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope.	Structure	2019	27	335	0	
5YF7	30239956	Crystals structure of Classical swine fever virus NS5B (residues 1-672)	2017-09-20	2018-09-19	Liu, W.,Shi, X.,Gong, P.	A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase.	Nucleic Acids Res.	2018	46	10840	10854	
5ZYT	30247721	Crystal structure of human MGME1 with 3' overhang double strand DNA3	2018-05-28	2018-09-19	Yang, C.,Wu, R.,Liu, H.,Chen, Y.,Gao, Y.,Chen, X.,Li, Y.,Ma, J.,Li, J.,Gan, J.	Structural insights into DNA degradation by human mitochondrial nuclease MGME1	Nucleic Acids Res.	2018	46	11075	11088	
5ZYV	30247721	Crystal structure of human MGME1 with single strand DNA2 and Ca2+	2018-05-28	2018-09-19	Yang, C.,Wu, R.,Liu, H.,Chen, Y.,Gao, Y.,Chen, X.,Li, Y.,Ma, J.,Li, J.,Gan, J.	Structural insights into DNA degradation by human mitochondrial nuclease MGME1	Nucleic Acids Res.	2018	46	11075	11088	
6AE5	30239956	Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A mutant, form 1)	2018-08-03	2018-09-19	Liu, W.,Shi, X.,Gong, P.	A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase.	Nucleic Acids Res.	2018	46	10840	10854	
6AE6	30239956	Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A mutant, form 2)	2018-08-03	2018-09-19	Liu, W.,Shi, X.,Gong, P.	A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase.	Nucleic Acids Res.	2018	46	10840	10854	
6AF0	30224485	Structure of Ctr9, Paf1 and Cdc73 ternary complex from Myceliophthora thermophila	2018-08-07	2018-09-19	Deng, P.,Zhou, Y.,Jiang, J.,Li, H.,Tian, W.,Cao, Y.,Qin, Y.,Kim, J.,Roeder, R.G.,Patel, D.J.,Wang, Z.	Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology.	Proc. Natl. Acad. Sci. U.S.A.	2018	115	9998	10003	
5ZMO	30409991	Sulfur binding domain of ScoMcrA complexed with phosphorothioated DNA	2018-04-04	2018-09-26	Liu, G.,Fu, W.,Zhang, Z.,He, Y.,Yu, H.,Wang, Y.,Wang, X.,Zhao, Y.,Deng, Z.,Wu, G.,He, X.	Structural basis for the recognition of sulfur in phosphorothioated DNA.	Nat Commun	2018	9	4689	4689	
5ZYQ	30228257	The Structure of Human PAF1/CTR9 complex	2018-05-28	2018-09-26	Xie, Y.,Zheng, M.,Chu, X.,Chen, Y.,Xu, H.,Wang, J.,Zhou, H.,Long, J.	Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.	Nat Commun	2018	9	3795	3795	
5YAD	30333187	Crystal structure of Marf1 Lotus domain from Mus musculus	2017-08-31	2018-10-03	Yao, Q.,Cao, G.,Li, M.,Wu, B.,Zhang, X.,Zhang, T.,Guo, J.,Yin, H.,Shi, L.,Chen, J.,Yu, X.,Zheng, L.,Ma, J.,Su, Y.Q.	Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice.	Proc. Natl. Acad. Sci. U.S.A.	2018	115	11250	11255	
5YBY		Structure of human Gliomedin	2017-09-05	2018-10-03	Liu, H.,Lin, Z.,Xu, F.	High resolution structure of human gliomedin	To Be Published	0	0	0	0	
5YGP	30941855	Human TNFRSF25 death domain mutant-D412E	2017-09-25	2018-10-03	Yin, X.,Li, W.,Ma, H.,Zeng, W.,Peng, C.,Li, Y.,Liu, M.,Chen, Q.,Zhou, R.,Jin, T.	Crystal structure and activation mechanism of DR3 death domain.	Febs J.	2019	286	2593	2610	
6A3V	30355497	Complex structure of human 4-1BB and 4-1BBL	2018-06-17	2018-10-10	Li, Y.,Tan, S.,Zhang, C.,Chai, Y.,He, M.,Zhang, C.W.,Wang, Q.,Tong, Z.,Liu, K.,Lei, Y.,Liu, W.J.,Liu, Y.,Tian, Z.,Cao, X.,Yan, J.,Qi, J.,Tien, P.,Gao, S.,Gao, G.F.	Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.	Cell Rep	2018	25	909	0	
6A3W	30355497	Complex structure of 4-1BB and utomilumab	2018-06-17	2018-10-10	Li, Y.,Tan, S.,Zhang, C.,Chai, Y.,He, M.,Zhang, C.W.,Wang, Q.,Tong, Z.,Liu, K.,Lei, Y.,Liu, W.J.,Liu, Y.,Tian, Z.,Cao, X.,Yan, J.,Qi, J.,Tien, P.,Gao, S.,Gao, G.F.	Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.	Cell Rep	2018	25	909	0	
6A5X	30275017	FXR-LBD with HNC180 and SRC1	2018-06-25	2018-10-10	Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.	Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding	J. Biol. Chem.	2018	293	18180	18191	
6A5Y	30275017	Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1	2018-06-25	2018-10-10	Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.	Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding	J. Biol. Chem.	2018	293	18180	18191	
6A5Z	30275017	Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC180 and 9cRA and SRC1	2018-06-25	2018-10-10	Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.	Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding	J. Biol. Chem.	2018	293	18180	18191	
6A60	30275017	Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1	2018-06-25	2018-10-10	Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.	Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding	J. Biol. Chem.	2018	293	18180	18191	
6AG0	31325505	The X-ray Crystallographic Structure of Maltooligosaccharide-forming Amylase from Bacillus stearothermophilus STB04	2018-08-09	2018-10-10	Xie, X.,Li, Y.,Ban, X.,Zhang, Z.,Gu, Z.,Li, C.,Hong, Y.,Cheng, L.,Jin, T.,Li, Z.	Crystal structure of a maltooligosaccharide-forming amylase from Bacillus stearothermophilus STB04.	Int.J.Biol.Macromol.	2019	138	394	402	
6AIJ		Cyclodextrin glycosyltransferase from Paenibacillus macerans mutant N603D	2018-08-24	2018-10-10	Ban, X.F.,Gu, Z.B.,Li, Z.F.,Li, Y.L.,Li, C.M.,Cheng, S.D.,Zhang, C.Y.,Jin, T.C.	Cyclodextrin glycosyltransferase from Paenibacillus macerans mutant N603D	To Be Published	0	0	0	0	
5YJC		Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm6	2017-10-10	2018-10-17	Zhao, Y.Q.,Gu, Y.J.,Zhu, X.F.,Cheng, W.	Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm3 and Csm6	To Be Published	0	0	0	0	
5YJD		Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm3	2017-10-10	2018-10-17	Zhao, Y.Q.,Gu, Y.J.,Zhu, X.F.,Cheng, W.	Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm3 and Csm6	To Be Published	0	0	0	0	
5YQL	29957526	Crystal structure of Sirt2 in complex with selective inhibitor A2I	2017-11-07	2018-10-17	Yang, L.L.,Wang, H.L.,Zhong, L.,Yuan, C.,Liu, S.Y.,Yu, Z.J.,Liu, S.,Yan, Y.H.,Wu, C.,Wang, Y.,Wang, Z.,Yu, Y.,Chen, Q.,Li, G.B.	X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.	Eur J Med Chem	2018	155	806	823	
5YQM	29957526	Crystal structure of Sirt2 in complex with selective inhibitor A29	2017-11-07	2018-10-17	Yang, L.L.,Wang, H.L.,Zhong, L.,Yuan, C.,Liu, S.Y.,Yu, Z.J.,Liu, S.,Yan, Y.H.,Wu, C.,Wang, Y.,Wang, Z.,Yu, Y.,Chen, Q.,Li, G.B.	X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.	Eur J Med Chem	2018	155	806	823	
5YQN	29957526	Crystal structure of Sirt2 in complex with selective inhibitor L55	2017-11-07	2018-10-17	Yang, L.L.,Wang, H.L.,Zhong, L.,Yuan, C.,Liu, S.Y.,Yu, Z.J.,Liu, S.,Yan, Y.H.,Wu, C.,Wang, Y.,Wang, Z.,Yu, Y.,Chen, Q.,Li, G.B.	X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.	Eur J Med Chem	2018	155	806	823	
5YQO	29957526	Crystal structure of Sirt2 in complex with selective inhibitor L5C	2017-11-07	2018-10-17	Yang, L.L.,Wang, H.L.,Zhong, L.,Yuan, C.,Liu, S.Y.,Yu, Z.J.,Liu, S.,Yan, Y.H.,Wu, C.,Wang, Y.,Wang, Z.,Yu, Y.,Chen, Q.,Li, G.B.	X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.	Eur J Med Chem	2018	155	806	823	
5YYZ	30289413	Crystal structure of the MEK1 FHA domain in complex with the HOP1 pThr318 peptide.	2017-12-11	2018-10-17	Xie, C.,He, C.,Jiang, Y.,Yu, H.,Cheng, L.,Nshogoza, G.,Ala, M.S.,Tian, C.,Wu, J.,Shi, Y.,Li, F.	Structural insights into the recognition of phosphorylated Hop1 by Mek1	Acta Crystallogr D Struct Biol	2018	74	1027	1038	
5Z69	29391496	Structure of the recombination mediator protein RecF-ATPrS in RecFOR pathway	2018-01-22	2018-10-17	Tang, Q.,Liu, Y.P.,Shan, H.H.,Tian, L.F.,Zhang, J.Z.,Yan, X.X.	ATP-dependent conformational change in ABC-ATPase RecF serves as a switch in DNA repair.	Sci Rep	2018	8	2127	2127	
6ALB		CREBBP bromodomain in complex with Cpd 30 (1-(3-(3-(1-methyl-1H-pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)	2017-08-07	2018-10-17	Murray, J.M.	Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300	To be published	0	0	0	0	
5YZ3	30135190	Crystal structure of T2R-TTL-28 complex	2017-12-12	2018-10-24	Ning, N.,Yu, Y.,Wu, M.,Zhang, R.,Zhang, T.,Zhu, C.,Huang, L.,Yun, C.H.,Benes, C.H.,Zhang, J.,Deng, X.,Chen, Q.,Ren, R.	A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.	Cancer Res.	2018	78	5949	5957	
5ZI6	30095198	The RING domain structure of MEX-3C	2018-03-14	2018-10-24	Moududee, S.A.,Jiang, Y.,Gilbert, N.,Xie, G.,Xu, Z.,Wu, J.,Gong, Q.,Tang, Y.,Shi, Y.	Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase	Protein Sci.	2018	27	1661	1669	
5ZQ0	30388185	Crystal structure of spRlmCD with U747loop RNA	2018-04-17	2018-10-24	Jiang, Y.,Yu, H.,Li, F.,Cheng, L.,Zhu, L.,Shi, Y.,Gong, Q.	Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD	PLoS Pathog.	2018	14	0	0	
5ZQ1	30388185	Crystal structure of spRlmCD with U1939loop RNA at 3.10 angstrom	2018-04-17	2018-10-24	Jiang, Y.,Yu, H.,Li, F.,Cheng, L.,Zhu, L.,Shi, Y.,Gong, Q.	Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD	PLoS Pathog.	2018	14	0	0	
6A8R	30315230	Crystal structure of DUX4 HD2 domain associated with ERG DNA binding site	2018-07-10	2018-10-24	Dong, X.,Zhang, H.,Cheng, N.,Li, K.,Meng, G.	DUX4HD2-DNAERGstructure reveals new insight into DUX4-Responsive-Element.	Leukemia	2019	33	550	553	
5Y1J		Crystal structure of human FXR in complex with a functional drug ligand	2017-07-20	2018-10-31	Lu, Y.,Li, Y.	Crystal structure of human FXR in complex with a functional drug liagnd	To Be Published	0	0	0	0	
5Z4A	30407553	Structure of Tailor in complex with AGU RNA	2018-01-10	2018-10-31	Cheng, L.,Li, F.,Jiang, Y.,Yu, H.,Xie, C.,Shi, Y.,Gong, Q.	Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.	Nucleic Acids Res.	2019	47	495	508	
5Z4C	30407553	Crystal structure of Tailor	2018-01-10	2018-10-31	Cheng, L.,Li, F.,Jiang, Y.,Yu, H.,Xie, C.,Shi, Y.,Gong, Q.	Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.	Nucleic Acids Res.	2019	47	495	508	
5Z4D	30407553	Structure of Tailor in complex with AGUU RNA	2018-01-11	2018-10-31	Cheng, L.,Li, F.,Jiang, Y.,Yu, H.,Xie, C.,Shi, Y.,Gong, Q.	Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.	Nucleic Acids Res.	2019	47	495	508	
5Z4J	30407553	Structure of Tailor in complex with U4 RNA	2018-01-11	2018-10-31	Cheng, L.,Li, F.,Jiang, Y.,Yu, H.,Xie, C.,Shi, Y.,Gong, Q.	Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.	Nucleic Acids Res.	2019	47	495	508	
5Z4M	30407553	Structure of TailorD343A with bound UTP and Mg	2018-01-11	2018-10-31	Cheng, L.,Li, F.,Jiang, Y.,Yu, H.,Xie, C.,Shi, Y.,Gong, Q.	Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.	Nucleic Acids Res.	2019	47	495	508	
5YPS	31098304	The structural basis of histone chaperoneVps75	2017-11-03	2018-11-07	Chen, Y.,Zhang, Y.,Ye, H.,Dou, Y.,Lu, D.,Li, X.,Limper, A.H.,Hua, J.,Su, D.	Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inPneumocystis carinii.	Signal Transduct Target Ther	2019	4	14	14	
5Z0Q	30141637	Crystal Structure of OvoB	2017-12-20	2018-11-07	Naowarojna, N.,Huang, P.,Cai, Y.,Song, H.,Wu, L.,Cheng, R.,Li, Y.,Wang, S.,Lyu, H.,Zhang, L.,Zhou, J.,Liu, P.	In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions.	Org. Lett.	2018	20	5427	5430	
5Z0Q	30141637	Crystal Structure of OvoB	2017-12-20	2018-11-07	Naowarojna, N.,Huang, P.,Cai, Y.,Song, H.,Wu, L.,Cheng, R.,Li, Y.,Wang, S.,Lyu, H.,Zhang, L.,Zhou, J.,Liu, P.	In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions.	Org. Lett.	2018	20	5427	5430	
5YRO		RanL182A in complex with RanBP1-CRM1	2017-11-09	2018-11-21	Sun, Q.,Zhang, Y.	RanL182A in complex with RanBP1-CRM1	To Be Published	0	0	0	0	
5YST		RanM189D in complex with RanBP1-CRM1	2017-11-15	2018-11-21	Sun, Q.,Zhang, Y.	RanM189D in complex with RanBP1-CRM1	To Be Published	0	0	0	0	
5YSU		Plumbagin in complex with CRM1-RanM189D-RanBP1	2017-11-15	2018-11-21	Sun, Q.,Zhang, Y.	RanL182A in complex with RanBP1-CRM1	To Be Published	0	0	0	0	
5YTB		RanY197A in complex with RanBP1-CRM1	2017-11-17	2018-11-21	Sun, Q.,Zhang, Y.	RanY197A in complex with RanBP1-CRM1	To Be Published	0	0	0	0	
5YTE	30407705	Large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with with natural dT:dATP base pair	2017-11-17	2018-11-21	Zeng, H.,Mondal, M.,Song, R.,Zhang, J.,Xia, B.,Liu, M.,Zhu, C.,He, B.,Gao, Y.Q.,Yi, C.	Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.	Angew. Chem. Int. Ed. Engl.	2019	58	130	133	
5YTH	30407705	Structure of large fragment of DNA Polymerase I from Thermus aquaticus Host-Guest complex with the unnatural base M-fC pair with dG	2017-11-17	2018-11-21	Zeng, H.,Mondal, M.,Song, R.,Zhang, J.,Xia, B.,Liu, M.,Zhu, C.,He, B.,Gao, Y.Q.,Yi, C.	Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.	Angew. Chem. Int. Ed. Engl.	2019	58	130	133	
5ZUG	30333234	Structure of the bacterial acetate channel SatP	2018-05-07	2018-11-21	Sun, P.,Li, J.,Zhang, X.,Guan, Z.,Xiao, Q.,Zhao, C.,Song, M.,Zhou, Y.,Mou, L.,Ke, M.,Guo, L.,Geng, J.,Deng, D.	Crystal structure of the bacterial acetate transporter SatP reveals that it forms a hexameric channel.	J. Biol. Chem.	2018	293	19492	19500	
6A1Z	30463954	Crystal Structure of dimeric Kinesin-3 KIF13B	2018-06-08	2018-11-21	Ren, J.Q.,Wang, S.,Chen, H.,Wang, W.J.,Huo, L.,Feng, W.	Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition.	Proc. Natl. Acad. Sci. U.S.A.	2018	115	0	0	
6IGB	30642898	the structure of Pseudomonas aeruginosa Periplasmic gluconolactonase, PpgL	2018-09-25	2018-11-21	Song, Y.J.,Wang, K.L.,Shen, Y.L.,Gao, J.,Li, T.,Zhu, Y.B.,Li, C.C.,He, L.H.,Zhou, Q.X.,Zhao, N.L.,Zhao, C.,Yang, J.,Huang, Q.,Mu, X.Y.,Li, H.,Dou, D.F.,Liu, C.,He, J.H.,Sun, B.,Bao, R.	Structural and Functional Insights into PpgL, a Metal-Independent beta-Propeller Gluconolactonase That Contributes toPseudomonas aeruginosaVirulence.	Infect.Immun.	2019	87	0	0	
5YQX	29758518	Crystal Structure Analysis of the BRD4	2017-11-08	2018-11-28	Xue, X.,Zhang, Y.,Wang, C.,Zhang, M.,Xiang, Q.,Wang, J.,Wang, A.,Li, C.,Zhang, C.,Zou, L.,Wang, R.,Wu, S.,Lu, Y.,Chen, H.,Ding, K.,Li, G.,Xu, Y.	Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer.	Eur.J.Med.Chem.	2018	152	542	559	
5Z2P	30341164	ThDP-Mn2+ complex of R413K variant of EcMenD soaked with 2-ketoglutarate for 5 min	2018-01-03	2018-11-28	Qin, M.M.,Song, H.G.,Dai, X.,Chen, Y.Z.,Guo, Z.H.	Two active site arginines are critical determinants of substrate binding and catalysis in MenD: a thiamine-dependent enzyme in menaquinone biosynthesis.	Biochem. J.	2018	475	3651	3667	
6IGO	30392906	Crystal structure of myelin protein zero-like protein 1 (MPZL1)	2018-09-25	2018-11-28	Yu, T.,Liang, L.,Zhao, X.,Yin, Y.	Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1	Biochem. Biophys. Res. Commun.	2018	506	883	890	
6IGT	30392906	MPZL1 mutant - V145G, Q146K, P147T and G148S	2018-09-26	2018-11-28	Yu, T.,Liang, L.,Zhao, X.,Yin, Y.	Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1	Biochem. Biophys. Res. Commun.	2018	506	883	890	
6IGW	30392906	MPZL1 mutant - S86G, V145G, Q146K,P147T,G148S	2018-09-26	2018-11-28	Yu, T.,Liang, L.,Zhao, X.,Yin, Y.	Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1	Biochem. Biophys. Res. Commun.	2018	506	883	890	
5Y5D		The crystal structure of VrEH2 mutant M263W	2017-08-08	2018-12-05	Xu, J.H.,Yu, H.L.,Zhou, J.H.,Kong, X.D.,Li, F.L.	The crystal structure of VrEH2 mutant M263W	To Be Published	0	0	0	0	
5YN5		Crystal structure of MERS-CoV nsp10/nsp16 complex	2017-10-24	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YN8		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAH	2017-10-24	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YNB		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to Sinefungin	2017-10-24	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Chen, Y.,Yang, Z.Z.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YNF		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to m7GpppA	2017-10-24	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Yang, Z.Z.,Liu, Q.Y.,Chen, Y.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YNI		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAM and m7GpppG	2017-10-24	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YNJ		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to m7GpppG	2017-10-24	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fa, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YNO		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAH and m7GpppA	2017-10-24	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Chen, Y.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YNP		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to sinefungin and m7GpppA	2017-10-25	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YNQ		Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAH and m7GpppG	2017-10-25	2018-12-05	Wei, S.M.,Yang, L.,Ke, Z.H.,Liu, Q.Y.,Yang, Z.Z.,Chen, Y.,Guo, D.Y.,Fan, C.P.	Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex	To Be Published	0	0	0	0	
5YTX	31160337	Crystal structure of YB1 cold-shock domain in complex with UCAACU	2017-11-20	2018-12-05	Yang, X.J.,Zhu, H.,Mu, S.R.,Wei, W.J.,Yuan, X.,Wang, M.,Liu, Y.,Hui, J.,Huang, Y.	Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.	J.Biol.Chem.	2019	294	10998	11010	
5YWJ		Global regulatory element SarX	2017-11-29	2018-12-05	Wang, Q.	Crystal structure of SarX from Staphylococcus aureus	To Be Published	0	0	0	0	
5YK5	29285400	structure of the human Lamtor4-Lamtor5 complex	2017-10-12	2018-12-12	Mu, Z.,Wang, L.,Deng, W.,Wang, J.,Wu, G.	Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane	Cell Discov	2017	3	17049	17049	
5ZVD	30541086	The crystal structure of NSun6 from Pyrococcus horikoshii	2018-05-10	2018-12-12	Li, J.,Li, H.,Long, T.,Dong, H.,Wang, E.D.,Liu, R.J.	Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.	Nucleic Acids Res.	2019	47	2041	2055	
5ZVE	30541086	The crystal structure of NSun6 from Pyrococcus horikoshii with SAH	2018-05-10	2018-12-12	Li, J.,Li, H.,Long, T.,Dong, H.,Wang, E.D.,Liu, R.J.	Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.	Nucleic Acids Res.	2019	47	2041	2055	
5ZVG	30541086	The crystal structure of NSun6 from Pyrococcus horikoshii with SAM	2018-05-10	2018-12-12	Li, J.,Li, H.,Long, T.,Dong, H.,Wang, E.D.,Liu, R.J.	Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.	Nucleic Acids Res.	2019	47	2041	2055	
5ZVH	30541086	The crystal structure of NSun6 from Pyrococcus horikoshii with SFG	2018-05-10	2018-12-12	Li, J.,Li, H.,Long, T.,Dong, H.,Wang, E.D.,Liu, R.J.	Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.	Nucleic Acids Res.	2019	47	2041	2055	
6AEM	30268503	Crystal structure of the PKD1 domain of Vibrio anguillarum Epp	2018-08-05	2018-12-12	Li, P.,Zang, K.,Li, Y.,Liu, C.,Ma, Q.	Structural basis for specific calcium binding by the polycystic-kidney-disease domain of Vibrio anguillarum protease Epp	Biochem. Biophys. Res. Commun.	2018	505	471	477	
6F4U		Crystal structure of reactive loop cleaved kallistatin at 1.9 angstrom resolution	2017-11-30	2018-12-12	Zhou, A.,Ma, L.	Crystal structure of human Kallistatin	To Be Published	0	0	0	0	
6IFN	30503210	Crystal structure of Type III-A CRISPR Csm complex	2018-09-20	2018-12-12	You, L.,Ma, J.,Wang, J.,Artamonova, D.,Wang, M.,Liu, L.,Xiang, H.,Severinov, K.,Zhang, X.,Wang, Y.	Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference	Cell	2019	176	239	0	
5ZZ9	30503778	Crystal structure of Homer2 EVH1/Drebrin PPXXF complex	2018-05-31	2018-12-19	Li, Z.,Liu, H.,Li, J.,Yang, Q.,Feng, Z.,Li, Y.,Yang, H.,Yu, C.,Wan, J.,Liu, W.,Zhang, M.	Homer Tetramer Promotes Actin Bundling Activity of Drebrin.	Structure	2019	27	27	0	
6A66	30413611	Placental protein 13/galectin-13 variant R53H with Tris	2018-06-26	2018-12-26	Su, J.,Cui, L.,Si, Y.,Song, C.,Li, Y.,Yang, T.,Wang, H.,Mayo, K.H.,Tai, G.,Zhou, Y.	Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose	Biosci. Rep.	2018	38	0	0	
6A82	30537137	Crystal structure of the C-terminal periplasmic domain of EcEptC from Escherichia coli	2018-07-06	2018-12-26	Zhao, Y.,Meng, Q.,Lai, Y.,Wang, L.,Zhou, D.,Dou, C.,Gu, Y.,Nie, C.,Wei, Y.,Cheng, W.	Structural and mechanistic insights into polymyxin resistance mediated by EptC originating from Escherichia coli.	FEBS J.	2019	286	750	764	
6A83	30537137	Crystal structure of the C-terminal periplasmic domain of EcEptC from Escherichia coli complex with Zn	2018-07-06	2018-12-26	Zhao, Y.,Meng, Q.,Lai, Y.,Wang, L.,Zhou, D.,Dou, C.,Gu, Y.,Nie, C.,Wei, Y.,Cheng, W.	Structural and mechanistic insights into polymyxin resistance mediated by EptC originating from Escherichia coli.	FEBS J.	2019	286	750	764	
6A9X	30504823	Crystal Structure of AnkG/GABARAP Complex	2018-07-16	2018-12-26	Nelson, A.D.,Caballero-Floran, R.N.,Rodriguez Diaz, J.C.,Hull, J.M.,Yuan, Y.,Li, J.,Chen, K.,Walder, K.K.,Lopez-Santiago, L.F.,Bennett, V.,McInnis, M.G.,Isom, L.L.,Wang, C.,Zhang, M.,Jones, K.S.,Jenkins, P.M.	Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.	Mol. Psychiatry	2018	0	0	0	
6AJF	30682372	Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis	2018-08-27	2018-12-26	Zhang, B.,Li, J.,Yang, X.,Wu, L.,Zhang, J.,Yang, Y.,Zhao, Y.,Zhang, L.,Yang, X.,Yang, X.,Cheng, X.,Liu, Z.,Jiang, B.,Jiang, H.,Guddat, L.W.,Yang, H.,Rao, Z.	Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.	Cell	2019	176	636	0	
6AJJ	30682372	Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with ICA38	2018-08-27	2018-12-26	Zhang, B.,Li, J.,Yang, X.,Wu, L.,Zhang, J.,Yang, Y.,Zhao, Y.,Zhang, L.,Yang, X.,Yang, X.,Cheng, X.,Liu, Z.,Jiang, B.,Jiang, H.,Guddat, L.W.,Yang, H.,Rao, Z.	Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.	Cell	2019	176	636	0	
5YZL		Crystal structure of human Archease D178A	2017-12-15	2019-01-02	Duan, S.Y.,Li, J.X.	Structural and mechanistic insights into human Archease mutant D178A	To Be Published	0	0	0	0	
5Z1R	29541371	Crystal Structure Analysis of the BRD4	2017-12-28	2019-01-02	Xiang, Q.,Zhang, Y.,Li, J.,Xue, X.,Wang, C.,Song, M.,Zhang, C.,Wang, R.,Li, C.,Wu, C.,Zhou, Y.,Yang, X.,Li, G.,Ding, K.,Xu, Y.	Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer.	Acs Med.Chem.Lett.	2018	9	262	267	
5Z2V	29633970	Crystal structure of RecR from Pseudomonas aeruginosa PAO1	2018-01-04	2019-01-02	Che, S.,Chen, Y.,Liang, Y.,Zhang, Q.,Bartlam, M.	Crystal structure of RecR, a member of the RecFOR DNA-repair pathway, from Pseudomonas aeruginosa PAO1.	Acta Crystallogr F Struct Biol	2018	74	222	230	
5Z6P	30523371	The crystal structure of an agarase, AgWH50C	2018-01-24	2019-01-02	Zhang, P.,Zhang, J.,Zhang, L.,Sun, J.,Li, Y.,Wu, L.,Zhou, J.,Xue, C.,Mao, X.	Structure-based design of agarase AgWH50C from Agarivorans gilvus WH0801 to enhance thermostability.	Appl. Microbiol. Biotechnol.	2019	103	1289	1298	
5ZM8	30581148	Crystal structure of ORP2-ORD in complex with PI(4,5)P2	2018-04-01	2019-01-02	Wang, H.,Ma, Q.,Qi, Y.,Dong, J.,Du, X.,Rae, J.,Wang, J.,Wu, W.F.,Brown, A.J.,Parton, R.G.,Wu, J.W.,Yang, H.	ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).	Mol. Cell	2019	73	458	0	
5YY6	31549053	Crystal structure of Arabidopsis thaliana HPPD truncated mutant complexed with Benquitrione	2017-12-08	2019-01-16	Lin, H.Y.,Chen, X.,Chen, J.N.,Wang, D.W.,Wu, F.X.,Lin, S.Y.,Zhan, C.G.,Wu, J.W.,Yang, W.C.,Yang, G.F.	Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery.	Research (Wash D C)	2019	2019	2602414	2602414	
5Z4P		Crystal structure of tubulin-stathmin-TTL-Compound TCA complex	2018-01-12	2019-01-16	Zhang, H.,Luo, C.	Discovery and Design of novel Tubulin inhibitors	To Be Published	0	0	0	0	
5ZFM		Ketoreductase LbCR mutant - M6	2018-03-06	2019-01-16	Gong, X.M.,Zhen, Q.,Li, F.L.,Zeng, B.B.,Zheng, G.W.,Xu, J.H.	Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor	Acs Catalysis	2019	9	147	153	
6IYA	31101334	Structure of the DNA binding domain of antitoxin CopASO	2018-12-14	2019-01-16	Zhao, R.,Li, Q.,Zhang, J.,Li, F.,Yao, J.,Zhang, J.,Liu, L.,Wang, X.,Zhang, X.	Structure and allosteric coupling of type II antitoxin CopASO.	Biochem.Biophys.Res.Commun.	2019	514	1122	1127	
5XJX	28536146	Pre-formed plant receptor ERL1-TMM complex	2017-05-04	2019-01-23	Lin, G.,Zhang, L.,Han, Z.,Yang, X.,Liu, W.,Li, E.,Chang, J.,Qi, Y.,Shpak, E.D.,Chai, J.	A receptor-like protein acts as a specificity switch for the regulation of stomatal development.	Genes Dev.	2017	31	927	938	
5YK3	29285400	human Ragulator complex	2017-10-12	2019-01-23	Mu, Z.,Wang, L.,Deng, W.,Wang, J.,Wu, G.	Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane	Cell Discov	2017	3	17049	17049	
5Z4U		Crystal Structure of T2R-TTL complex with 7a3	2018-01-14	2019-01-23	Lai, Q.,Wang, Y.,Yang, J.,Yao, Y.	Crystal Structure of T2R-TTL complex with 7a3	To Be Published	0	0	0	0	
5Z4Y	30618115	Crystal structure of PaCysB NTD domain with space group P4	2018-01-18	2019-01-23	Song, Y.,Yang, C.,Chen, G.,Zhang, Y.,Seng, Z.,Cai, Z.,Zhang, C.,Yang, L.,Gan, J.,Liang, H.	Molecular insights into the master regulator CysB-mediated bacterial virulence in Pseudomonas aeruginosa.	Mol.Microbiol.	2019	111	1195	1210	
5Z4Z	30618115	Crystal structure of PaCysB NTD domain with space group C2	2018-01-15	2019-01-23	Song, Y.,Yang, C.,Chen, G.,Zhang, Y.,Seng, Z.,Cai, Z.,Zhang, C.,Yang, L.,Gan, J.,Liang, H.	Molecular insights into the master regulator CysB-mediated bacterial virulence in Pseudomonas aeruginosa.	Mol.Microbiol.	2019	111	1195	1210	
5Z50	30618115	Crystal structure of PaCysB regulatory domain	2018-01-15	2019-01-23	Song, Y.,Yang, C.,Chen, G.,Zhang, Y.,Seng, Z.,Cai, Z.,Zhang, C.,Yang, L.,Gan, J.,Liang, H.	Molecular insights into the master regulator CysB-mediated bacterial virulence in Pseudomonas aeruginosa.	Mol.Microbiol.	2019	111	1195	1210	
5Z5T	30385738	The first bromodomain of BRD4 with compound BDF-2141	2018-01-20	2019-01-23	Chen, W.,Zhang, H.,Chen, Z.,Jiang, H.,Liao, L.,Fan, S.,Xing, J.,Xie, Y.,Chen, S.,Ding, H.,Chen, K.,Jiang, H.,Luo, C.,Zheng, M.,Yao, Z.,Huang, Y.,Zhang, Y.	Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.	Oncogenesis	2018	7	83	83	
5Z5U	30385738	The first bromodomain of BRD4 with compound BDF-2254	2018-01-20	2019-01-23	Chen, W.,Zhang, H.,Chen, Z.,Jiang, H.,Liao, L.,Fan, S.,Xing, J.,Xie, Y.,Chen, S.,Ding, H.,Chen, K.,Jiang, H.,Luo, C.,Zheng, M.,Yao, Z.,Huang, Y.,Zhang, Y.	Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.	Oncogenesis	2018	7	83	83	
5Z5V	30385738	The first bromodomain of BRD4 with compound BDF-1253	2018-01-20	2019-01-23	Chen, W.,Zhang, H.,Chen, Z.,Jiang, H.,Liao, L.,Fan, S.,Xing, J.,Xie, Y.,Chen, S.,Ding, H.,Chen, K.,Jiang, H.,Luo, C.,Zheng, M.,Yao, Z.,Huang, Y.,Zhang, Y.	Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.	Oncogenesis	2018	7	83	83	
6AGI	30699349	Crystal Structure of EFHA2 in Ca-binding State	2018-08-11	2019-01-23	Xing, Y.,Wang, M.,Wang, J.,Nie, Z.,Wu, G.,Yang, X.,Shen, Y.	Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter.	Cell Rep	2019	26	1203	0	
6AGJ	30699349	Crystal Structure of EFHA2 in Apo State	2018-08-11	2019-01-23	Xing, Y.,Wang, M.,Wang, J.,Nie, Z.,Wu, G.,Yang, X.,Shen, Y.	Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter.	Cell Rep	2019	26	1203	0	
6IFO	30606466	Crystal structure of AcrIIA2-SpyCas9-sgRNA ternary complex	2018-09-20	2019-01-23	Liu, L.,Yin, M.,Wang, M.,Wang, Y.	Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race.	Mol. Cell	2019	73	611	0	
5Y2K		A human antibody AF4H1L1	2017-07-26	2019-01-30	Xiao, H.,Qi, J.,Gao, F.G.	An H3-clade neutralizing antibody screened from an H7N9 patient that binds group 2 influenza A hemagglutinins	To Be Published	0	0	0	0	
5Z7F		Horse Heart Myoglobin Mutant -V68A/I107Y-Sulfide Derivative	2018-01-28	2019-01-30	Yi, J.	Horse Heart Myoglobin Mutant -V68A/I107Y-Sulfide Derivative	To Be Published	0	0	0	0	
5Z8H		APC with an inhibitor	2018-01-31	2019-02-06	Zhang, J.,Yang, X.Y.,Song, K.	APC with an inhibitor	To Be Published	0	0	0	0	
5Z8R		BRD4 Bromodomain 1 with an inhibitor	2018-02-01	2019-02-06	Xiao, S.,Chen, S.,Chen, H.	BRD4 Bromodomain 1 with an inhibitor	To Be Published	0	0	0	0	
5Z8Z		BRD4 Bromodomain 1 with an inhibitor	2018-02-01	2019-02-06	Xiao, S.,Chen, S.,Chen, H.	BRD4 Bromodomain 1 with an inhibitor	To Be Published	0	0	0	0	
5Z90		BRD4 Bromodomain 1 with an inhibitor	2018-02-01	2019-02-06	Xiao, S.,Chen, S.,Chen, H.	BRD4 Bromodomain 1 with an inhibitor	To Be Published	0	0	0	0	
5Z9K		BRD4 Bromodomain 1 with an inhibitor	2018-02-03	2019-02-06	Xiao, S.,Chen, S.,Chen, H.	BRD4 Bromodomain 1 with an inhibitor	To Be Published	0	0	0	0	
6J5C	30760569	Louping ill virus envelope protein	2019-01-10	2019-02-06	Yang, X.,Qi, J.,Peng, R.,Dai, L.,Gould, E.A.,Gao, G.F.,Tien, P.	Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.	J. Virol.	2019	93	0	0	
6J5D	30760569	Complex structure of MAb 4.2-scFv with louping ill virus envelope protein Domain III	2019-01-10	2019-02-06	Yang, X.,Qi, J.,Peng, R.,Dai, L.,Gould, E.A.,Gao, G.F.,Tien, P.	Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.	J. Virol.	2019	93	0	0	
6J5F	30760569	Complex structure of MAb 4.2-scFv with tick-borne encephalitis virus envelope protein Domain III	2019-01-10	2019-02-06	Yang, X.,Qi, J.,Peng, R.,Dai, L.,Gould, E.A.,Gao, G.F.,Tien, P.	Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.	J. Virol.	2019	93	0	0	
6J5G	30760569	Complex structure of MAb 4.2-scFv with tick-borne encephalitis virus envelope protein	2019-01-10	2019-02-06	Yang, X.,Qi, J.,Peng, R.,Dai, L.,Gould, E.A.,Gao, G.F.,Tien, P.	Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.	J. Virol.	2019	93	0	0	
5ZAS	31489163	Crystal structure of 5-formylcytosine containing decamer dsDNA	2018-02-08	2019-02-13	Fu, T.,Liu, L.,Yang, Q.L.,Wang, Y.,Xu, P.,Zhang, L.,Liu, S.,Dai, Q.,Ji, Q.,Xu, G.L.,He, C.,Luo, C.,Zhang, L.	Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.	Chem Sci	2019	10	7407	7417	
5ZAT	31489163	Crystal structure of 5-carboxylcytosine containing decamer dsDNA	2018-02-08	2019-02-13	Fu, T.,Liu, L.,Yang, Q.L.,Wang, Y.,Xu, P.,Zhang, L.,Liu, S.,Dai, Q.,Ji, Q.,Xu, G.L.,He, C.,Luo, C.,Zhang, L.	Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.	Chem Sci	2019	10	7407	7417	
5ZB7	31709791	CTX-M-64 apoenzyme	2018-02-10	2019-02-13	Cheng, Q.,Xu, C.,Chai, J.,Zhang, R.,Wai Chi Chan, E.,Chen, S.	Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.	Acs Infect Dis.	2020	6	577	587	
6IVZ	30625326	Crystal structure of 5A ScFv complexed with YFV-China sE in postfusion state	2018-12-04	2019-02-13	Lu, X.,Xiao, H.,Li, S.,Pang, X.,Song, J.,Liu, S.,Cheng, H.,Li, Y.,Wang, X.,Huang, C.,Guo, T.,Ter Meulen, J.,Daffis, S.,Yan, J.,Dai, L.,Rao, Z.,Klenk, H.D.,Qi, J.,Shi, Y.,Gao, G.F.	Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.	Cell Rep	2019	26	438	0	
6IW0	30625326	Crystal structure of 5A ScFv in complex with YFV-17D sE in postfusion state	2018-12-04	2019-02-13	Lu, X.,Xiao, H.,Li, S.,Pang, X.,Song, J.,Liu, S.,Cheng, H.,Li, Y.,Wang, X.,Huang, C.,Guo, T.,Ter Meulen, J.,Daffis, S.,Yan, J.,Dai, L.,Rao, Z.,Klenk, H.D.,Qi, J.,Shi, Y.,Gao, G.F.	Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.	Cell Rep	2019	26	438	0	
6IW1	30625326	Crystal structure of YFV-17D sE in postfusion state	2018-12-04	2019-02-13	Lu, X.,Xiao, H.,Li, S.,Pang, X.,Song, J.,Liu, S.,Cheng, H.,Li, Y.,Wang, X.,Huang, C.,Guo, T.,Ter Meulen, J.,Daffis, S.,Yan, J.,Dai, L.,Rao, Z.,Klenk, H.D.,Qi, J.,Shi, Y.,Gao, G.F.	Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.	Cell Rep	2019	26	438	0	
6IW2	30625326	Crystal structure of 5A ScFv in complex with YFV-17D sE in prefusion state	2018-12-04	2019-02-13	Lu, X.,Xiao, H.,Li, S.,Pang, X.,Song, J.,Liu, S.,Cheng, H.,Li, Y.,Wang, X.,Huang, C.,Guo, T.,Ter Meulen, J.,Daffis, S.,Yan, J.,Dai, L.,Rao, Z.,Klenk, H.D.,Qi, J.,Shi, Y.,Gao, G.F.	Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.	Cell Rep	2019	26	438	0	
6IW4	30625326	Crystal structure of YFV-17D sE in prefusion state	2018-12-04	2019-02-13	Lu, X.,Xiao, H.,Li, S.,Pang, X.,Song, J.,Liu, S.,Cheng, H.,Li, Y.,Wang, X.,Huang, C.,Guo, T.,Ter Meulen, J.,Daffis, S.,Yan, J.,Dai, L.,Rao, Z.,Klenk, H.D.,Qi, J.,Shi, Y.,Gao, G.F.	Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.	Cell Rep	2019	26	438	0	
6IW5	30625326	Crystal structure of YFV-China sE in prefusion state	2018-12-04	2019-02-13	Lu, X.,Xiao, H.,Li, S.,Pang, X.,Song, J.,Liu, S.,Cheng, H.,Li, Y.,Wang, X.,Huang, C.,Guo, T.,Ter Meulen, J.,Daffis, S.,Yan, J.,Dai, L.,Rao, Z.,Klenk, H.D.,Qi, J.,Shi, Y.,Gao, G.F.	Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.	Cell Rep	2019	26	438	0	
6A50		structure of benzoylformate decarboxylases in complex with cofactor TPP	2018-06-21	2019-02-20	Lu, X.,Liu, Y.,Yang, Y.,Wang, S.,Wang, Q.,Wang, X.,Yan, Z.,Cheng, J.,Liu, C.,Yang, X.,Luo, H.,Yang, S.,Gou, J.,Ye, L.,Lu, L.,Zhang, Z.,Guo, Y.,Nie, Y.,Lin, J.,Li, S.,Cai, T.,Ma, H.,Wang, W.,Liu, Y.,Li, Y.,Jiang, H.,Tian, C.	A Synthetic Pathway for Acetyl-Coenzyme A Biosynthesis	Nat Commun	2019	0	0	0	
6A54	30770407	Crystal structure of DddK mutant Y64A	2018-06-21	2019-02-20	Peng, M.,Chen, X.L.,Zhang, D.,Wang, X.J.,Wang, N.,Wang, P.,Todd, J.D.,Zhang, Y.Z.,Li, C.Y.	Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.	Appl. Environ. Microbiol.	2019	85	0	0	
6A55	30770407	Crystal structure of DddK mutant Y122A	2018-06-21	2019-02-20	Peng, M.,Chen, X.L.,Zhang, D.,Wang, X.J.,Wang, N.,Wang, P.,Todd, J.D.,Zhang, Y.Z.,Li, C.Y.	Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK.	Appl. Environ. Microbiol.	2019	85	0	0	
6A8G	30707839	The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5	2018-07-08	2019-02-20	Wang, D.,Yang, Y.,Jiang, L.,Wang, Y.,Li, J.,Andreasen, P.A.,Chen, Z.,Huang, M.,Xu, P.	Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.	J.Med.Chem.	2019	62	2172	2183	
6IR8	30783673	Rice WRKY/DNA complex	2018-11-12	2019-02-20	Cheng, X.,Zhao, Y.,Jiang, Q.,Yang, J.,Zhao, W.,Taylor, I.A.,Peng, Y.L.,Wang, D.,Liu, J.	Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain.	Nucleic Acids Res.	2019	47	4308	4318	
6JEQ	32355041	Crystal structure of Pullulanase from Paenibacillus barengoltzii complex with beta-cyclodextrin	2019-02-07	2019-02-20	Huang, P.,Wu, S.,Yang, S.,Yan, Q.,Jiang, Z.	Structural basis of carbohydrate binding in domain C of a type I pullulanase from Paenibacillus barengoltzii.	Acta Crystallogr D Struct Biol	2020	76	447	457	
5ZDS	31196628	Crystal structure of the second PDZ domain of Frmpd2	2018-02-24	2019-02-27	Lu, X.,Zhang, Q.,Wang, T.	The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.	Biochem.Biophys.Res.Commun.	2019	516	63	67	
6A7U	30064909	Crystal structure of histone H2A.Bbd-H2B dimer	2018-07-04	2019-02-27	Dai, L.,Xie, X.,Zhou, Z.	Crystal structure of the histone heterodimer containing histone variant H2A.Bbd.	Biochem. Biophys. Res. Commun.	2018	503	1786	1791	
6IMJ	30674878	The crystal structure of Se-AsfvLIG:DNA complex	2018-10-23	2019-02-27	Chen, Y.,Liu, H.,Yang, C.,Gao, Y.,Yu, X.,Chen, X.,Cui, R.,Zheng, L.,Li, S.,Li, X.,Ma, J.,Huang, Z.,Li, J.,Gan, J.	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.	Nat Commun	2019	10	387	387	
6IMK	30674878	The crystal structure of AsfvLIG:CG complex	2018-10-23	2019-02-27	Chen, Y.,Liu, H.,Yang, C.,Gao, Y.,Yu, X.,Chen, X.,Cui, R.,Zheng, L.,Li, S.,Li, X.,Ma, J.,Huang, Z.,Li, J.,Gan, J.	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.	Nat Commun	2019	10	387	387	
6IML	30674878	The crystal structure of AsfvLIG:CT1 complex	2018-10-23	2019-02-27	Chen, Y.,Liu, H.,Yang, C.,Gao, Y.,Yu, X.,Chen, X.,Cui, R.,Zheng, L.,Li, S.,Li, X.,Ma, J.,Huang, Z.,Li, J.,Gan, J.	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.	Nat Commun	2019	10	387	387	
6IMN	30674878	The crystal structure of AsfvLIG:CT2 complex	2018-10-23	2019-02-27	Chen, Y.,Liu, H.,Yang, C.,Gao, Y.,Yu, X.,Chen, X.,Cui, R.,Zheng, L.,Li, S.,Li, X.,Ma, J.,Huang, Z.,Li, J.,Gan, J.	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.	Nat Commun	2019	10	387	387	
6IYV	30686533	Crystal sturucture of L,D-transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with ertapenem adduct	2018-12-17	2019-02-27	Zhao, F.,Hou, Y.J.,Zhang, Y.,Wang, D.C.,Li, D.F.	The 1-beta-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2for ertapenem than for imipenem.	Biochem. Biophys. Res. Commun.	2019	510	254	260	
6IYW	30686533	Crystal sturucture of L,D-transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with Imipenem adduct	2018-12-17	2019-02-27	Zhao, F.,Hou, Y.J.,Zhang, Y.,Wang, D.C.,Li, D.F.	The 1-beta-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem.	Biochem. Biophys. Res. Commun.	2019	510	254	260	
6J07	30718482	Crystal structure of human TERB2 and TERB1	2018-12-21	2019-02-27	Wang, Y.,Chen, Y.,Chen, J.,Wang, L.,Nie, L.,Long, J.,Chang, H.,Wu, J.,Huang, C.,Lei, M.	The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.	Nat Commun	2019	10	564	564	
6J08	30718482	Crystal structure of human MAJIN and TERB2	2018-12-21	2019-02-27	Wang, Y.,Chen, Y.,Chen, J.,Wang, L.,Nie, L.,Long, J.,Chang, H.,Wu, J.,Huang, C.,Lei, M.	The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.	Nat Commun	2019	10	564	564	
6J23	31318636	Crystal structure of arabidopsis ADAL complexed with GMP	2018-12-30	2019-02-27	Wu, B.,Zhang, D.,Nie, H.,Shen, S.,Li, Y.,Li, S.	Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing.	Rna Biol.	2019	16	1504	1512	
6NZS		Dextranase AoDex KQ11	2019-02-14	2019-02-27	Ren, W.,Yan, W.,Gu, L.,Feng, Y.,Dong, D.,Wang, S.,Wang, C.,Lyu, M.	Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus	To Be Published	0	0	0	0	
5ZF2	31314784	Crystal structure of Trxlp from Edwardsiella tarda EIB202	2018-03-02	2019-03-06	Yang, D.,Liu, X.,Xu, W.,Gu, Z.,Yang, C.,Zhang, L.,Tan, J.,Zheng, X.,Wang, Z.,Quan, S.,Zhang, Y.,Liu, Q.	The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection.	Plos Pathog.	2019	15	0	0	
5ZTM	30649456	Crystal structure of MLE dsRBDs in complex with roX2 (R2H1)	2018-05-04	2019-03-06	Lv, M.,Yao, Y.,Li, F.,Xu, L.,Yang, L.,Gong, Q.,Xu, Y.Z.,Shi, Y.,Fan, Y.J.,Tang, Y.	Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.	Nucleic Acids Res.	2019	47	3142	3157	
6IUI	30737283	Crystal structure of GIT1 PBD domain in complex with Paxillin LD4 motif	2018-11-28	2019-03-06	Liang, M.,Xie, X.,Pan, J.,Jin, G.,Yu, C.,Wei, Z.	Structural basis of the target-binding mode of the G protein-coupled receptor kinase-interacting protein in the regulation of focal adhesion dynamics.	J. Biol. Chem.	2019	294	5827	5839	
6IXO	30804213	Apo structure of Myo2-GTD	2018-12-11	2019-03-06	Tang, K.,Li, Y.,Yu, C.,Wei, Z.	Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2.	J.Biol.Chem.	2019	294	5896	5906	
6JHF	32355041	Crystal structure of apo Pullulanase from Paenibacillus barengoltzii	2019-02-18	2019-03-06	Huang, P.,Wu, S.,Yang, S.,Yan, Q.,Jiang, Z.	Structural basis of carbohydrate binding in domain C of a type I pullulanase from Paenibacillus barengoltzii.	Acta Crystallogr D Struct Biol	2020	76	447	457	
5ZT0	30422398	Crystal Structure of Protein Phosphate 1 Complexed with PP1 binding domain of GL	2018-05-01	2019-03-13	Yu, J.,Deng, T.,Xiang, S.	Structural basis for protein phosphatase 1 recruitment by glycogen-targeting subunits	FEBS J.	2018	285	4646	4659	
5ZVL	30346751	Crystal Structure of Wheat Glutarredoxin	2018-05-11	2019-03-13	Sun, X.,Chen, M.,Jia, F.,Hou, Y.,Hu, S.Q.	Crystal Structure of Wheat Glutaredoxin and Its Application in Improving the Processing Quality of Flour.	J. Agric. Food Chem.	2018	66	12079	12087	
6IPC	30770832	Non-native human ferritin 8-mer	2018-11-03	2019-03-13	Zang, J.,Chen, H.,Zhang, X.,Zhang, C.,Guo, J.,Du, M.,Zhao, G.	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages.	Nat Commun	2019	10	778	778	
6IPQ	30770832	Non-native ferritin 8-mer mutant-C90A/C102A/C130A	2018-11-03	2019-03-13	Zang, J.,Chen, H.,Zhang, X.,Zhang, C.,Guo, J.,Du, M.,Zhao, G.	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages.	Nat Commun	2019	10	778	778	
6JCJ	30803758	Structure of crolibulin in complex with tubulin	2019-01-29	2019-03-13	Zhang, Z.,Wang, C.,Ma, L.,Jiang, X.,Wu, C.,Wang, Y.,Jiang, Y.,Zheng, W.,Yang, Y.,Ma, Y.,Yang, J.	Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design.	Biochem. Biophys. Res. Commun.	2019	511	381	386	
5ZAD	30297860	Human topoisomerase II beta in complex with DNA	2018-02-07	2019-03-20	Sun, L.Y.,Zhu, L.W.,Tang, Y.J.	Increasing the distance between two monomers of topoisomerase II beta under the action of antitumor agent 4 beta-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin.	Sci Rep	2018	8	14949	14949	
5ZH9		Crystal Structures of Mutant Endo-beta-1,4-xylanase II (Y88F)	2018-03-12	2019-03-20	Zhang, X.,Wan, Q.	Crystal Structures of Mutant Endo-beta-1,4-xylanase II	To be published	0	0	0	0	
5ZIW		Crystal Structures of Mutant Endo-beta-1,4-xylanase(Y77F)	2018-03-17	2019-03-20	Wan, Q.,Zhang, X.	Crystal Structures of Endo-beta-1,4-xylanase II	to be published	0	0	0	0	
5ZJK	31785296	Structure of myroilysin	2018-03-20	2019-03-20	Ran, T.,Li, W.,Sun, B.,Xu, M.,Qiu, S.,Xu, D.Q.,He, J.,Wang, W.	Crystal structure of mature myroilysin and implication for its activation mechanism.	Int.J.Biol.Macromol.	2019	0	0	0	
5ZXL	30839292	Structure of GldA from E.coli	2018-05-21	2019-03-20	Zhang, J.,Nanjaraj Urs, A.N.,Lin, L.,Zhou, Y.,Hu, Y.,Hua, G.,Gao, Q.,Yuchi, Z.,Zhang, Y.	Structure of glycerol dehydrogenase (GldA) from Escherichia coli.	Acta Crystallogr F Struct Biol	2019	75	176	183	
5ZXL	30839292	Structure of GldA from E.coli	2018-05-21	2019-03-20	Zhang, J.,Nanjaraj Urs, A.N.,Lin, L.,Zhou, Y.,Hu, Y.,Hua, G.,Gao, Q.,Yuchi, Z.,Zhang, Y.	Structure of glycerol dehydrogenase (GldA) from Escherichia coli.	Acta Crystallogr F Struct Biol	2019	75	176	183	
6AI8	30653991	Cab2 mutant-H337A	2018-08-22	2019-03-20	Zheng, P.,Zhang, M.,Khan, M.H.,Liu, H.,Jin, Y.,Yue, J.,Gao, Y.,Teng, M.,Zhu, Z.,Niu, L.	Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.	J. Mol. Biol.	2019	431	764	776	
6AIK	30653991	Cab2 mutant H337A complex with phosphopantothenoyl-CMP	2018-08-24	2019-03-20	Zheng, P.,Zhang, M.,Khan, M.H.,Liu, H.,Jin, Y.,Yue, J.,Gao, Y.,Teng, M.,Zhu, Z.,Niu, L.	Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.	J. Mol. Biol.	2019	431	764	776	
6AIP	30653991	Cab2 mutant-H337A complex with phosphopantothenoylcystine	2018-08-24	2019-03-20	Zheng, P.,Zhang, M.,Khan, M.H.,Liu, H.,Jin, Y.,Yue, J.,Gao, Y.,Teng, M.,Zhu, Z.,Niu, L.	Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.	J. Mol. Biol.	2019	431	764	776	
6INE	30827843	Crystal Structure of human ASH1L-MRG15 complex	2018-10-25	2019-03-20	Hou, P.,Huang, C.,Liu, C.P.,Yang, N.,Yu, T.,Yin, Y.,Zhu, B.,Xu, R.M.	Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding.	Structure	2019	27	837	0	
6J69	30784589	Structure of KIBRA and Dendrin Complex	2019-01-14	2019-03-20	Ji, Z.,Li, H.,Yang, Z.,Huang, X.,Ke, X.,Ma, S.,Lin, Z.,Lu, Y.,Zhang, M.	Kibra Modulates Learning and Memory via Binding to Dendrin.	Cell Rep	2019	26	2064	0	
6JMK	30928093	Ribosomal protein S7 from Mycobacterium tuberculosis	2019-03-11	2019-03-20	Li, Z.,Wu, D.,Zhan, B.,Hu, X.,Gan, J.,Ji, C.,Li, J.	Structural insights into the complex of trigger factor chaperone and ribosomal protein S7 from Mycobacterium tuberculosis.	Biochem. Biophys. Res. Commun.	2019	512	838	844	
5Z9T	31004719	a new PL6 alginate lyase complex with trisaccharide	2018-02-05	2019-03-27	Lyu, Q.,Zhang, K.,Shi, Y.,Li, W.,Diao, X.,Liu, W.	Structural insights into a novel Ca2+-independent PL-6 alginate lyase from Vibrio OU02 identify the possible subsites responsible for product distribution.	Biochim Biophys Acta Gen Subj	2019	1863	1167	1176	
5ZKL	31713614	Crystal structure of Streptococcus pneumoniae SP_0782 (residues 7-79) in complex with single-stranded DNA dT12	2018-03-24	2019-03-27	Li, S.,Lu, G.,Fang, X.,Ramelot, T.A.,Kennedy, M.A.,Zhou, X.,Gong, P.,Zhang, X.,Liu, M.,Zhu, J.,Yang, Y.	Structural insight into the length-dependent binding of ssDNA by SP_0782 from Streptococcus pneumoniae, reveals a divergence in the DNA-binding interface of PC4-like proteins.	Nucleic Acids Res.	2020	48	432	444	
5ZKX	31419524	The postfusion structure of human-infecting Bourbon virus envelope glycoprotein	2018-03-26	2019-03-27	Bai, C.,Qi, J.,Wu, Y.,Wang, X.,Gao, G.F.,Peng, R.,Gao, F.	Postfusion structure of human-infecting Bourbon virus envelope glycoprotein.	J.Struct.Biol.	2019	208	99	106	
5ZL2		Crystal structure of Bourbon virus envelope glycoprotein at pH8.0	2018-03-26	2019-03-27	Bai, C.Z.,Qi, J.X.,Wu, Y.,Wang, X.J.,Gao, G.F.,Peng, R.C.,Gao, F.	The postfusion structure of human-infecting Bourbon virus envelope glycoprotein implicates the host adaptation properties of thogotoviruses	To Be Published	0	0	0	0	
6AEB	30664728	Crystal structure of xCas9 in complex with sgRNA and target DNA (AAG PAM)	2018-08-04	2019-03-27	Guo, M.,Ren, K.,Zhu, Y.,Tang, Z.,Wang, Y.,Zhang, B.,Huang, Z.	Structural insights into a high fidelity variant of SpCas9.	Cell Res.	2019	29	183	192	
6AEG	30664728	Crystal structure of xCas9 in complex with sgRNA and target DNA (GAT PAM)	2018-08-04	2019-03-27	Guo, M.,Ren, K.,Zhu, Y.,Tang, Z.,Wang, Y.,Zhang, B.,Huang, Z.	Structural insights into a high fidelity variant of SpCas9.	Cell Res.	2019	29	183	192	
6ILW	30502092	Crystal structure of PETase from Ideonella sakaiensis	2018-10-19	2019-03-27	Liu, C.,Shi, C.,Zhu, S.,Wei, R.,Yin, C.C.	Structural and functional characterization of polyethylene terephthalate hydrolase from Ideonella sakaiensis.	Biochem. Biophys. Res. Commun.	2019	508	289	294	
6ILX	30502092	Crystal structure of PETase W159F mutant from Ideonella sakaiensis	2018-10-20	2019-03-27	Liu, C.,Shi, C.,Zhu, S.,Wei, R.,Yin, C.C.	Structural and functional characterization of polyethylene terephthalate hydrolase from Ideonella sakaiensis.	Biochem. Biophys. Res. Commun.	2019	508	289	294	
6JNL	31048693	REF6 ZnF2-4-NAC004 complex	2019-03-17	2019-03-27	Qiu, Q.,Mei, H.,Deng, X.,He, K.,Wu, B.,Yao, Q.,Zhang, J.,Lu, F.,Ma, J.,Cao, X.	DNA methylation repels targeting of Arabidopsis REF6.	Nat Commun	2019	10	2063	2063	
6JNM	31048693	REF6 ZnF2-4-NAC004-mC3 complex	2019-03-17	2019-03-27	Qiu, Q.,Mei, H.,Deng, X.,He, K.,Wu, B.,Yao, Q.,Zhang, J.,Lu, F.,Ma, J.,Cao, X.	DNA methylation repels targeting of Arabidopsis REF6.	Nat Commun	2019	10	2063	2063	
6JNN	31048693	REF6 ZnF2-4-NAC004-mC1 complex	2019-03-17	2019-03-27	Qiu, Q.,Mei, H.,Deng, X.,He, K.,Wu, B.,Yao, Q.,Zhang, J.,Lu, F.,Ma, J.,Cao, X.	DNA methylation repels targeting of Arabidopsis REF6.	Nat Commun	2019	10	2063	2063	
5ZGN		The crystal structure of KacTA-DNA complex	2018-03-09	2019-04-03	Qian, H.L.,Yao, Q.Q.,Gan, J.H.,Ou, H.Y.	The crystal structure of KacTA-DNA complex	To Be Published	0	0	0	0	
5ZHH		Structure of Inositol monophosphatase from Anabaena (Nostoc) sp. PCC 7120	2018-03-13	2019-04-03	Zhang, S.R.,Wang, F.K.,Hu, Z.,Zong, Q.,Jiang, L.	Structure of Inositol monophosphatase from Anabaena (Nostoc) sp. PCC 7120	To Be Published	0	0	0	0	
5ZJW		Crystal Structure of PAK4 in complex with inhibitor CZg353	2018-03-22	2019-04-03	Zhao, F.,Li, H.	Crystal Structure of PAK4 in complex with inhibitor CZg353	To be published	0	0	0	0	
5ZZ3	30902636	Crystal structure of intracellular B30.2 domain of BTN3A3	2018-05-30	2019-04-03	Yang, Y.,Li, L.,Yuan, L.,Zhou, X.,Duan, J.,Xiao, H.,Cai, N.,Han, S.,Ma, X.,Liu, W.,Chen, C.C.,Wang, L.,Li, X.,Chen, J.,Kang, N.,Chen, J.,Shen, Z.,Malwal, S.R.,Liu, W.,Shi, Y.,Oldfield, E.,Guo, R.T.,Zhang, Y.	A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.	Immunity	2019	50	1043	0	
6A71	30643139	Crystal Structure of Human ATP7B and TM Complex	2018-06-30	2019-04-03	Fang, T.,Chen, W.,Sheng, Y.,Yuan, S.,Tang, Q.,Li, G.,Huang, G.,Su, J.,Zhang, X.,Zang, J.,Liu, Y.	Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein.	Nat Commun	2019	10	186	186	
6AD3	30533541	Structural characterization of the condensation domain from Monacolin K polyketide synthase MokA	2018-07-30	2019-04-03	Wang, L.,Yuan, M.,Zheng, J.	Crystal structure of the condensation domain from lovastatin polyketide synthase.	Synth Syst Biotechnol	2019	4	10	15	
6IEG	30842217	Crystal structure of human MTR4	2018-09-14	2019-04-03	Wang, J.,Chen, J.,Wu, G.,Zhang, H.,Du, X.,Chen, S.,Zhang, L.,Wang, K.,Fan, J.,Gao, S.,Wu, X.,Zhang, S.,Kuai, B.,Zhao, P.,Chi, B.,Wang, L.,Li, G.,Wong, C.C.L.,Zhou, Y.,Li, J.,Yun, C.,Cheng, H.	NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.	Genes Dev.	2019	33	536	549	
6IEH	30842217	Crystal structures of the hMTR4-NRDE2 complex	2018-09-14	2019-04-03	Wang, J.,Chen, J.,Wu, G.,Zhang, H.,Du, X.,Chen, S.,Zhang, L.,Wang, K.,Fan, J.,Gao, S.,Wu, X.,Zhang, S.,Kuai, B.,Zhao, P.,Chi, B.,Wang, L.,Li, G.,Wong, C.C.L.,Zhou, Y.,Li, J.,Yun, C.,Cheng, H.	NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.	Genes Dev.	2019	33	536	549	
6IF3	30905672	Complex structure of Rab35 and its effector ACAP2	2018-09-18	2019-04-03	Lin, L.,Shi, Y.,Wang, M.,Wang, C.,Zhu, J.,Zhang, R.	Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.	Structure	2019	27	729	0	
6JKN	30957851	Crystal Structure of G-quadruplex Formed by Bromo-substituted Human Telomeric DNA	2019-03-01	2019-04-03	Geng, Y.,Liu, C.,Zhou, B.,Cai, Q.,Miao, H.,Shi, X.,Xu, N.,You, Y.,Fung, C.P.,Din, R.U.,Zhu, G.	The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA.	Nucleic Acids Res.	2019	47	5395	5404	
5ZMD	30718435	Crystal structure of FTO in complex with m6dA modified ssDNA	2018-04-02	2019-04-10	Zhang, X.,Wei, L.H.,Wang, Y.,Xiao, Y.,Liu, J.,Zhang, W.,Yan, N.,Amu, G.,Tang, X.,Zhang, L.,Jia, G.	Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.	Proc. Natl. Acad. Sci. U.S.A.	2019	116	2919	2924	
5ZMZ		Amyloid core of RIP1	2018-04-06	2019-04-10	Li, J.X.,Zheng, J.	Amyloid core of RIP1	To Be Published	0	0	0	0	
5ZUV	30989115	Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1	2018-05-08	2019-04-10	Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.	Sci Adv	2019	5	0	0	
5ZUV	30989115	Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1	2018-05-08	2019-04-10	Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.	Sci Adv	2019	5	0	0	
5ZVK	30989115	Crystal Structure of the Human Coronavirus MERS HR1 motif in complex with pan-CoVs inhibitor EK1	2018-05-11	2019-04-10	Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.	Sci Adv	2019	5	0	0	
5ZVK	30989115	Crystal Structure of the Human Coronavirus MERS HR1 motif in complex with pan-CoVs inhibitor EK1	2018-05-11	2019-04-10	Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.	Sci Adv	2019	5	0	0	
5ZVM	30989115	Crystal Structure of the Human Coronavirus SARS HR1 motif in complex with pan-CoVs inhibitor EK1	2018-05-11	2019-04-10	Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.	Sci Adv	2019	5	0	0	
5ZVM	30989115	Crystal Structure of the Human Coronavirus SARS HR1 motif in complex with pan-CoVs inhibitor EK1	2018-05-11	2019-04-10	Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.K.,Wang, Q.,Du, L.,Tan, W.,Wilson, I.A.,Jiang, S.,Yang, B.,Lu, L.	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.	Sci Adv	2019	5	0	0	
6IEA	30936489	Structure of RVFV Gn and human monoclonal antibody R13	2018-09-13	2019-04-10	Wang, Q.,Ma, T.,Wu, Y.,Chen, Z.,Zeng, H.,Tong, Z.,Gao, F.,Qi, J.,Zhao, Z.,Chai, Y.,Yang, H.,Wong, G.,Bi, Y.,Wu, L.,Shi, R.,Yang, M.,Song, J.,Jiang, H.,An, Z.,Wang, J.,Yilma, T.D.,Shi, Y.,Liu, W.J.,Liang, M.,Qin, C.,Gao, G.F.,Yan, J.	Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.	Nat Microbiol	2019	4	1231	1241	
6IEB	30936489	Structure of RVFV Gn and human monoclonal antibody R15	2018-09-13	2019-04-10	Wang, Q.,Ma, T.,Wu, Y.,Chen, Z.,Zeng, H.,Tong, Z.,Gao, F.,Qi, J.,Zhao, Z.,Chai, Y.,Yang, H.,Wong, G.,Bi, Y.,Wu, L.,Shi, R.,Yang, M.,Song, J.,Jiang, H.,An, Z.,Wang, J.,Yilma, T.D.,Shi, Y.,Liu, W.J.,Liang, M.,Qin, C.,Gao, G.F.,Yan, J.	Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.	Nat Microbiol	2019	4	1231	1241	
6IEC	30936489	Structure of RVFV Gn and human monoclonal antibody R17	2018-09-13	2019-04-10	Wang, Q.,Ma, T.,Wu, Y.,Chen, Z.,Zeng, H.,Tong, Z.,Gao, F.,Qi, J.,Zhao, Z.,Chai, Y.,Yang, H.,Wong, G.,Bi, Y.,Wu, L.,Shi, R.,Yang, M.,Song, J.,Jiang, H.,An, Z.,Wang, J.,Yilma, T.D.,Shi, Y.,Liu, W.J.,Liang, M.,Qin, C.,Gao, G.F.,Yan, J.	Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.	Nat Microbiol	2019	4	1231	1241	
6IEK	30936489	Structure of RVFV Gn and human monoclonal antibody R12	2018-09-14	2019-04-10	Wang, Q.,Ma, T.,Wu, Y.,Chen, Z.,Zeng, H.,Tong, Z.,Gao, F.,Qi, J.,Zhao, Z.,Chai, Y.,Yang, H.,Wong, G.,Bi, Y.,Wu, L.,Shi, R.,Yang, M.,Song, J.,Jiang, H.,An, Z.,Wang, J.,Yilma, T.D.,Shi, Y.,Liu, W.J.,Liang, M.,Qin, C.,Gao, G.F.,Yan, J.	Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.	Nat Microbiol	2019	4	1231	1241	
6IP0	30899015	Crystal structure of Arabidopsis thaliana JMJ13 catalytic domain in complex with AKG	2018-11-01	2019-04-10	Zheng, S.,Hu, H.,Ren, H.,Yang, Z.,Qiu, Q.,Qi, W.,Liu, X.,Chen, X.,Cui, X.,Li, S.,Zhou, B.,Sun, D.,Cao, X.,Du, J.	The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.	Nat Commun	2019	10	1303	1303	
6IP4	30899015	Crystal structure of Arabidopsis thaliana JMJ13 catalytic domain in complex with NOG and an H3K27me3 peptide	2018-11-02	2019-04-10	Zheng, S.,Hu, H.,Ren, H.,Yang, Z.,Qiu, Q.,Qi, W.,Liu, X.,Chen, X.,Cui, X.,Li, S.,Zhou, B.,Sun, D.,Cao, X.,Du, J.	The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.	Nat Commun	2019	10	1303	1303	
5ZIT	32353513	Crystal structure of human Enterovirus D68 RdRp in complex with NADPH	2018-03-17	2019-04-17	Li, L.,Wang, M.,Chen, Y.,Hu, T.,Yang, Y.,Zhang, Y.,Bi, G.,Wang, W.,Liu, E.,Han, J.,Lu, T.,Su, D.	Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.	J.Struct.Biol.	2020	0	107510	107510	
5ZIU		Crystal structure of human Entervirus D68 RdRp	2018-03-17	2019-04-17	Wang, M.L.,Zhang, Y.,Dou, Y.S.,Chen, Y.P.,Lu, D.R.,Jiang, H.,Chen, Y.J.,Li, L.,Zhang, C.H.,Shi, Q.L.,Su, D.	Crystal structure of human Entervirus D68 RdRp in complex with NADPH	To Be Published	0	0	0	0	
5ZNZ	30941855	Structure of mDR3 DD with MBP tag mutant-I387V	2018-04-12	2019-04-17	Yin, X.,Li, W.,Ma, H.,Zeng, W.,Peng, C.,Li, Y.,Liu, M.,Chen, Q.,Zhou, R.,Jin, T.	Crystal structure and activation mechanism of DR3 death domain.	Febs J.	2019	286	2593	2610	
6AGL	30946901	Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli	2018-08-13	2019-04-17	Cui, D.,Deng, A.,Bai, H.,Yang, Z.,Liang, Y.,Liu, Z.,Qiu, Q.,Wang, L.,Liu, S.,Zhang, Y.,Shi, Y.,Qi, J.,Wen, T.	Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli.	J.Struct.Biol.	2019	206	322	334	
6AGM	30946901	Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli	2018-08-13	2019-04-17	Cui, D.,Deng, A.,Bai, H.,Yang, Z.,Liang, Y.,Liu, Z.,Qiu, Q.,Wang, L.,Liu, S.,Zhang, Y.,Shi, Y.,Qi, J.,Wen, T.	Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli.	J.Struct.Biol.	2019	206	322	334	
6IIP		Apo-form structure of the HRP3 PWWP domain	2018-10-07	2019-04-24	Wang, Z.,Tian, W.	Apo-form structure of the HRP3 PWWP domain	Nucleic Acids Res.	2019	0	0	0	
6IIQ		Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA	2018-10-07	2019-04-24	Wang, Z.,Tian, W.	Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA	Nucleic Acids Res.	2019	0	0	0	
6IIR		Complex structure of the HRP3 PWWP domain with a 10-bp GC-rich DNA	2018-10-07	2019-04-24	Wang, Z.,Tian, W.	Complex structure of the HRP3 PWWP domain with a 10-bp GC-rich DNA	Nucleic Acids Res.	2019	0	0	0	
6IIS		Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me3-containing histone peptide	2018-10-07	2019-04-24	Wang, Z.,Tian, W.	Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me3-containing histone peptide	Nucleic Acids Res.	2019	0	0	0	
6J4K	30974511	Structural basis for the target DNA recognition and binding by the MYB domain of phosphate starvation response 1	2019-01-09	2019-04-24	Jiang, M.,Sun, L.,Isupov, M.N.,Littlechild, J.A.,Wu, X.,Wang, Q.,Wang, Q.,Yang, W.,Wu, Y.	Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1.	Febs J.	2019	286	2809	2821	
5ZRM		Phosphoglycerate mutase 1 complexed with a small molecule inhibitor In-AC	2018-04-24	2019-05-01	Jiang, L.L.,Zhou, L.	Phosphoglycerate mutase 1 complexed with a small molecule inhibitor In-AC	To Be Published	0	0	0	0	
6IYU	30770441	Crystal Structure Analysis of an Eukaryotic Membrane Protein	2018-12-17	2019-05-01	Wang, X.H.,Su, M.,Gao, F.,Xie, W.,Zeng, Y.,Li, D.L.,Liu, X.L.,Zhao, H.,Qin, L.,Li, F.,Liu, Q.,Clarke, O.B.,Lam, S.M.,Shui, G.H.,Hendrickson, W.A.,Chen, Y.H.	Structural basis for activity of TRIC counter-ion channels in calcium release.	Proc.Natl.Acad.Sci.USA	2019	116	4238	4243	
6IYX	30770441	Crystal Structure Analysis of a Eukaryotic Membrane Protein	2018-12-17	2019-05-01	Wang, X.H.,Su, M.,Gao, F.,Xie, W.,Zeng, Y.,Li, D.L.,Liu, X.L.,Zhao, H.,Qin, L.,Li, F.,Liu, Q.,Clarke, O.B.,Lam, S.M.,Shui, G.H.,Hendrickson, W.A.,Chen, Y.H.	Structural basis for activity of TRIC counter-ion channels in calcium release.	Proc.Natl.Acad.Sci.USA	2019	116	4238	4243	
6IYZ	30770441	Structural basis for activity of TRIC counter-ion channels in calcium release	2018-12-18	2019-05-01	Wang, X.H.,Su, M.,Gao, F.,Xie, W.,Zeng, Y.,Li, D.L.,Liu, X.L.,Zhao, H.,Qin, L.,Li, F.,Liu, Q.,Clarke, O.B.,Lam, S.M.,Shui, G.H.,Hendrickson, W.A.,Chen, Y.H.	Structural basis for activity of TRIC counter-ion channels in calcium release.	Proc.Natl.Acad.Sci.USA	2019	116	4238	4243	
6IZ0	30770441	Crystal Structure Analysis of a Eukaryotic Membrane Protein	2018-12-18	2019-05-01	Wang, X.H.,Su, M.,Gao, F.,Xie, W.,Zeng, Y.,Li, D.L.,Liu, X.L.,Zhao, H.,Qin, L.,Li, F.,Liu, Q.,Clarke, O.B.,Lam, S.M.,Shui, G.H.,Hendrickson, W.A.,Chen, Y.H.	Structural basis for activity of TRIC counter-ion channels in calcium release.	Proc.Natl.Acad.Sci.USA	2019	116	4238	4243	
6IZ1	30770441	Crystal Structure Analysis of a Eukaryotic Membrane Protein	2018-12-18	2019-05-01	Wang, X.H.,Su, M.,Gao, F.,Xie, W.,Zeng, Y.,Li, D.L.,Liu, X.L.,Zhao, H.,Qin, L.,Li, F.,Liu, Q.,Clarke, O.B.,Lam, S.M.,Shui, G.H.,Hendrickson, W.A.,Chen, Y.H.	Structural basis for activity of TRIC counter-ion channels in calcium release.	Proc.Natl.Acad.Sci.USA	2019	116	4238	4243	
6IZ4	30770441	Crystal Structure Analysis of TRIC counter-ion channels in calcium release	2018-12-18	2019-05-01	Wang, X.H.,Su, M.,Gao, F.,Xie, W.,Zeng, Y.,Li, D.L.,Liu, X.L.,Zhao, H.,Qin, L.,Li, F.,Liu, Q.,Clarke, O.B.,Lam, S.M.,Shui, G.H.,Hendrickson, W.A.,Chen, Y.H.	Structural basis for activity of TRIC counter-ion channels in calcium release.	Proc.Natl.Acad.Sci.USA	2019	116	4238	4243	
6J1L	30964293	Crystal Structure Analysis of the ROR gamma(C455E)	2018-12-28	2019-05-01	Zhang, Y.,Wu, X.,Xue, X.,Li, C.,Wang, J.,Wang, R.,Zhang, C.,Wang, C.,Shi, Y.,Zou, L.,Li, Q.,Huang, Z.,Hao, X.,Loomes, K.,Wu, D.,Chen, H.W.,Xu, J.,Xu, Y.	Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.	J.Med.Chem.	2019	62	4716	4730	
6J1O	31149354	Crystal structure of a SAM-dependent methyltransferase LepI from Aspergillus flavus	2018-12-28	2019-05-01	Sun, Q.,Hu, Y.,Gu, Y.,Huang, J.,He, J.,Luo, L.,Yang, Y.,Yin, S.,Dou, C.,Wang, T.,Fu, X.,He, L.,Qi, S.,Zhu, X.,Yang, S.,Wei, X.,Cheng, W.	Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.	Signal Transduct Target Ther	2019	4	17	17	
6J24	31149354	Crystal structure of a SAM-dependent methyltransferase LepI in complex with its substrate	2018-12-30	2019-05-01	Sun, Q.,Hu, Y.,Gu, Y.,Huang, J.,He, J.,Luo, L.,Yang, Y.,Yin, S.,Dou, C.,Wang, T.,Fu, X.,He, L.,Qi, S.,Zhu, X.,Yang, S.,Wei, X.,Cheng, W.	Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.	Signal Transduct Target Ther	2019	4	17	17	
6J46	31149354	LepI-SAH complex structure	2019-01-08	2019-05-01	Sun, Q.,Hu, Y.,Gu, Y.,Huang, J.,He, J.,Luo, L.,Yang, Y.,Yin, S.,Dou, C.,Wang, T.,Fu, X.,He, L.,Qi, S.,Zhu, X.,Yang, S.,Wei, X.,Cheng, W.	Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.	Signal Transduct Target Ther	2019	4	17	17	
6J4P	31235911	Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications	2019-01-10	2019-05-01	Wang, N.,Bosc, C.,Ryul Choi, S.,Boulan, B.,Peris, L.,Olieric, N.,Bao, H.,Krichen, F.,Chen, L.,Andrieux, A.,Olieric, V.,Moutin, M.J.,Steinmetz, M.O.,Huang, H.	Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.	Nat.Struct.Mol.Biol.	2019	26	571	582	
6J4Q	31235911	Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications	2019-01-10	2019-05-01	Wang, N.,Bosc, C.,Ryul Choi, S.,Boulan, B.,Peris, L.,Olieric, N.,Bao, H.,Krichen, F.,Chen, L.,Andrieux, A.,Olieric, V.,Moutin, M.J.,Steinmetz, M.O.,Huang, H.	Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.	Nat.Struct.Mol.Biol.	2019	26	571	582	
6J4U	31235911	Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications	2019-01-10	2019-05-01	Wang, N.,Bosc, C.,Ryul Choi, S.,Boulan, B.,Peris, L.,Olieric, N.,Bao, H.,Krichen, F.,Chen, L.,Andrieux, A.,Olieric, V.,Moutin, M.J.,Steinmetz, M.O.,Huang, H.	Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.	Nat.Struct.Mol.Biol.	2019	26	571	582	
5ZUU		Crystal structure of AtCPSF30 YTH domain in complex with 10mer m6A-modified RNA	2018-05-08	2019-05-15	Hou, Y.,Sun, J.,Wu, B.,Gao, Y.,Nie, H.,Nie, Z.,Quan, S.,Wang, Y.,Cao, X.,Li, S.	CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis.	Mol Plant	2021	0	0	0	
6J36	31263685	crystal structure of Mycoplasma hyopneumoniae Enolase	2019-01-04	2019-05-15	Chen, R.,Yu, Y.,Feng, Z.,Gan, R.,Xie, X.,Zhang, Z.,Xie, Q.,Wang, W.,Ran, T.,Zhang, W.,Xiong, Q.,Shao, G.	Featured Species-Specific Loops Are Found in the Crystal Structure ofMhpEno, a Cell Surface Adhesin FromMycoplasma hyopneumoniae.	Front Cell Infect Microbiol	2019	9	209	209	
6J7J	31010899	Crystal structure of Pseudomonas aeruginosa Earp	2019-01-18	2019-05-15	He, C.,Liu, N.,Li, F.,Jia, X.,Peng, H.,Liu, Y.,Xiao, Y.	Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.	J.Bacteriol.	2019	201	0	0	
6J7K	31010899	Crystal structure of Pseudomonas aeruginosa Earp in complex with TDP-Rha	2019-01-18	2019-05-15	He, C.,Liu, N.,Li, F.,Jia, X.,Peng, H.,Liu, Y.,Xiao, Y.	Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.	J.Bacteriol.	2019	201	0	0	
6J7L	31010899	Crystal structure of Pseudomonas aeruginosa Earp in complex with TDP	2019-01-18	2019-05-15	He, C.,Liu, N.,Li, F.,Jia, X.,Peng, H.,Liu, Y.,Xiao, Y.	Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.	J.Bacteriol.	2019	201	0	0	
6J7M	31010899	Complex structure of the Pseudomonas aeruginosa rhamnosyltransferase EarP with the acceptor elongation factor EF-P	2019-01-18	2019-05-15	He, C.,Liu, N.,Li, F.,Jia, X.,Peng, H.,Liu, Y.,Xiao, Y.	Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P.	J.Bacteriol.	2019	201	0	0	
6JD7	31243272	Crystal structure of anti-CRISPR protein AcrIIC2 dimer	2019-01-31	2019-05-15	Thavalingam, A.,Cheng, Z.,Garcia, B.,Huang, X.,Shah, M.,Sun, W.,Wang, M.,Harrington, L.,Hwang, S.,Hidalgo-Reyes, Y.,Sontheimer, E.J.,Doudna, J.,Davidson, A.R.,Moraes, T.F.,Wang, Y.,Maxwell, K.L.	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.	Nat Commun	2019	10	2806	2806	
6JDJ	31243272	Crystal structure of AcrIIC2 dimer in complex with partial Nme1Cas9	2019-02-01	2019-05-15	Thavalingam, A.,Cheng, Z.,Garcia, B.,Huang, X.,Shah, M.,Sun, W.,Wang, M.,Harrington, L.,Hwang, S.,Hidalgo-Reyes, Y.,Sontheimer, E.J.,Doudna, J.,Davidson, A.R.,Moraes, T.F.,Wang, Y.,Maxwell, K.L.	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.	Nat Commun	2019	10	2806	2806	
6JDX	31243272	Crystal structure of AcrIIC2 dimer in complex with partial Nme1Cas9 preprocessed with protease alpha-Chymotrypsin	2019-02-02	2019-05-15	Thavalingam, A.,Cheng, Z.,Garcia, B.,Huang, X.,Shah, M.,Sun, W.,Wang, M.,Harrington, L.,Hwang, S.,Hidalgo-Reyes, Y.,Sontheimer, E.J.,Doudna, J.,Davidson, A.R.,Moraes, T.F.,Wang, Y.,Maxwell, K.L.	Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.	Nat Commun	2019	10	2806	2806	
6JL0	31073025	Crystal structure of VvPlpA from Vibrio vulnificus	2019-03-03	2019-05-15	Wan, Y.,Liu, C.,Ma, Q.	Structural analysis of aVibriophospholipase reveals an unusual Ser-His-chloride catalytic triad.	J.Biol.Chem.	2019	294	11391	11401	
6JL1	31073025	Crystal structure of VvPlpA G389D from Vibrio vulnificus	2019-03-03	2019-05-15	Wan, Y.,Liu, C.,Ma, Q.	Structural analysis of aVibriophospholipase reveals an unusual Ser-His-chloride catalytic triad.	J.Biol.Chem.	2019	294	11391	11401	
6JL2	31073025	Crystal structure of VvPlpA G389N from Vibrio vulnificus	2019-03-03	2019-05-15	Wan, Y.,Liu, C.,Ma, Q.	Structural analysis of aVibriophospholipase reveals an unusual Ser-His-chloride catalytic triad.	J.Biol.Chem.	2019	294	11391	11401	
6JO8	31080063	The complex structure of CHIKV envelope glycoprotein bound to human MXRA8	2019-03-20	2019-05-15	Song, H.,Zhao, Z.,Chai, Y.,Jin, X.,Li, C.,Yuan, F.,Liu, S.,Gao, Z.,Wang, H.,Song, J.,Vazquez, L.,Zhang, Y.,Tan, S.,Morel, C.M.,Yan, J.,Shi, Y.,Qi, J.,Gao, F.,Gao, G.F.	Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein.	Cell	2019	177	1714	0	
5ZS7		Acetylation of lysine 100 in Phosphoglycerate mutase 1	2018-04-28	2019-05-22	Jiang, L.L.,Zhou, L.	Acetylation of lysine 100 in Phosphoglycerate mutase 1	To Be Published	0	0	0	0	
5ZY6		catechol methyltransferase spCOMT	2018-05-22	2019-05-22	Wang, Q.	structural insight into spCOMT	To Be Published	0	0	0	0	
6JYN	31118252	GII.13/21 noroviruses recognize glycans with a terminal beta-galactose via an unconventional glycan binding site	2019-04-26	2019-05-22	Cong, X.,Sun, X.M.,Qi, J.X.,Li, H.B.,Chai, W.G.,Zhang, Q.,Wang, H.,Kong, X.Y.,Song, J.,Pang, L.L.,Jin, M.,Li, D.D.,Tan, M.,Duan, Z.J.	GII.13/21 Noroviruses Recognize Glycans with a Terminal beta-Galactose via an Unconventional Glycan Binding Site.	J.Virol.	2019	93	0	0	
6JYO	31118252	GII.13/21 noroviruses recognize glycans with a terminal beta-galactose via an unconventional glycan binding site	2019-04-27	2019-05-22	Cong, X.,Sun, X.M.,Qi, J.X.,Li, H.B.,Chai, W.G.,Zhang, Q.,Wang, H.,Kong, X.Y.,Song, J.,Pang, L.L.,Jin, M.,Li, D.D.,Tan, M.,Duan, Z.J.	GII.13/21 Noroviruses Recognize Glycans with a Terminal beta-Galactose via an Unconventional Glycan Binding Site.	J.Virol.	2019	93	0	0	
6JYR	31118252	GII.13/21 noroviruses recognize glycans with a terminal beta-galactose via an unconventional glycan binding site	2019-04-27	2019-05-22	Cong, X.,Sun, X.M.,Qi, J.X.,Li, H.B.,Chai, W.G.,Zhang, Q.,Wang, H.,Kong, X.Y.,Song, J.,Pang, L.L.,Jin, M.,Li, D.D.,Tan, M.,Duan, Z.J.	GII.13/21 Noroviruses Recognize Glycans with a Terminal beta-Galactose via an Unconventional Glycan Binding Site.	J.Virol.	2019	93	0	0	
6JYS	31118252	GII.13/21 noroviruses recognize glycans with a terminal beta-galactose via an unconventional glycan binding site	2019-04-27	2019-05-22	Cong, X.,Sun, X.M.,Qi, J.X.,Li, H.B.,Chai, W.G.,Zhang, Q.,Wang, H.,Kong, X.Y.,Song, J.,Pang, L.L.,Jin, M.,Li, D.D.,Tan, M.,Duan, Z.J.	GII.13/21 Noroviruses Recognize Glycans with a Terminal beta-Galactose via an Unconventional Glycan Binding Site.	J.Virol.	2019	93	0	0	
6J44	31092331	Crystal structure of the redefined DNA-binding domain of human XPA	2019-01-07	2019-05-29	Lian, F.M.,Yang, X.,Yang, W.,Jiang, Y.L.,Qian, C.	Structural characterization of the redefined DNA-binding domain of human XPA.	Biochem.Biophys.Res.Commun.	2019	514	985	990	
6J9A	30962525	Crystal structure of Arabidopsis thaliana VAL1 in complex with FLC DNA fragment	2019-01-22	2019-05-29	Tao, Z.,Hu, H.,Luo, X.,Jia, B.,Du, J.,He, Y.	Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.	Nat.Plants	2019	5	424	435	
6J9B	30962525	Arabidopsis FUS3-DNA complex	2019-01-22	2019-05-29	Tao, Z.,Hu, H.,Luo, X.,Jia, B.,Du, J.,He, Y.	Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.	Nat.Plants	2019	5	424	435	
6J9C	30962525	Crystal structure of Arabidopsis thaliana transcription factor LEC2-DNA complex	2019-01-22	2019-05-29	Tao, Z.,Hu, H.,Luo, X.,Jia, B.,Du, J.,He, Y.	Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.	Nat.Plants	2019	5	424	435	
6JCX	31131408	Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H and 6nt RNA	2019-01-30	2019-05-29	Fang, C.,Li, L.,Shen, L.,Shi, J.,Wang, S.,Feng, Y.,Zhang, Y.	Structures and mechanism of transcription initiation by bacterial ECF factors.	Nucleic Acids Res.	2019	47	7094	7104	
5ZZU		Crystal structure of the C-terminal periplasmic domain of EcEptC from Escherichia coli- complex with Zn	2018-06-04	2019-06-05	Zhao, Y.Q.,Lai, Y.J.,Zhou, D.,Dou, C.,Gu, Y.J.,Nie, C.L.,Wei, Y.Q.,Cheng, W.	Structural and mechanistic insights into polymyxin resistance mediated by EptC originating from Escherichia coli	To Be Published	0	0	0	0	
6AAX	31251801	Crystal structure of TFB1M and h45 with SAM in homo sapiens	2018-07-19	2019-06-05	Liu, X.,Shen, S.,Wu, P.,Li, F.,Liu, X.,Wang, C.,Gong, Q.,Wu, J.,Yao, X.,Zhang, H.,Shi, Y.	Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function.	Nucleic Acids Res.	2019	47	7648	7665	
6AJK	31251801	Crystal structure of TFB1M and h45 in homo sapiens	2018-08-28	2019-06-05	Liu, X.,Shen, S.,Wu, P.,Li, F.,Liu, X.,Wang, C.,Gong, Q.,Wu, J.,Yao, X.,Zhang, H.,Shi, Y.	Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function.	Nucleic Acids Res.	2019	47	7648	7665	
5ZOL	32519699	Crystal structure of a three sites mutantion of FSAA complexed with HA and product	2018-04-13	2019-06-12	Yang, X.,Wu, L.,Li, A.,Ye, L.,Zhou, J.,Yu, H.	The engineering of decameric d-fructose-6-phosphate aldolase A by combinatorial modulation of inter- and intra-subunit interactions.	Chem.Commun.(Camb.)	2020	56	7561	7564	
5ZTC	31607473	Apo structure of TetR family transcription regulator Lmo2088 of Listeria monocytogenes EGDe	2018-05-02	2019-06-12	Samad, A.,Li, Y.,Zhang, C.,Chen, F.,Zeng, W.,Fan, X.,Jin, T.	X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes.	Biochem.Biophys.Res.Commun.	2019	520	434	440	
5ZTO		Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003	2018-05-04	2019-06-12	Zhu, S.J.,Yun, C.H.	Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003	To Be Published	0	0	0	0	
6A6O		Crystal structure of acetyl ester-xyloside bifunctional hydrolase from Caldicellulosiruptor lactoaceticus	2018-06-28	2019-06-12	Cao, H.,Sun, L.C.,Huang, Y.,Liu, X.,Yang, D.,Liu, T.F.,Jia, X.J.,Wen, B.T.,Gu, T.,Wang, F.Z.,Xin, F.J.	Structural Insights into the Dual-Substrate Recognition and Catalytic Mechanisms of a Bifunctional Acetyl Ester-Xyloside Hydrolase from Caldicellulosiruptor lactoaceticus.	Acs Catalysis	2019	9	1739	1747	
6AEO	30266644	TssL periplasmic domain	2018-08-06	2019-06-12	Wang, X.,Sun, B.,Xu, M.,Qiu, S.,Xu, D.,Ran, T.,He, J.,Wang, W.	Crystal structure of the periplasmic domain of TssL, a key membrane component of Type VI secretion system.	Int.J.Biol.Macromol.	2018	120	1474	1479	
6K5G	32493959	Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete Phytophthora capsici	2019-05-28	2019-06-12	Yang, C.,Li, J.,Huang, Z.,Zhang, X.,Gao, X.,Zhu, C.,Morris, P.F.,Zhang, X.	Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.	Sci Rep	2020	10	9051	9051	
6K5H	32493959	Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete Phytophthora capsici.	2019-05-28	2019-06-12	Yang, C.,Li, J.,Huang, Z.,Zhang, X.,Gao, X.,Zhu, C.,Morris, P.F.,Zhang, X.	Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.	Sci Rep	2020	10	9051	9051	
6K5K	32493959	Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete Phytophthora capsici.	2019-05-29	2019-06-12	Yang, C.,Li, J.,Huang, Z.,Zhang, X.,Gao, X.,Zhu, C.,Morris, P.F.,Zhang, X.	Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.	Sci Rep	2020	10	9051	9051	
6A38	33883894	MVM NS2 NES in complex with CRM1-Ran-RanBP1	2018-06-15	2019-06-19	Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q.	Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.	Int J Nanomedicine	2021	16	2833	2847	
6A3A	33883894	MVM NES mutant Nm2 in complex with CRM1-Ran-RanBP1	2018-06-15	2019-06-19	Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q.	Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.	Int J Nanomedicine	2021	16	2833	2847	
6A3B	33883894	MVM NES mutant Nm13 in complex with CRM1-Ran-RanBP1	2018-06-15	2019-06-19	Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q.	Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.	Int J Nanomedicine	2021	16	2833	2847	
6A3C	33883894	MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1	2018-06-15	2019-06-19	Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q.	Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.	Int J Nanomedicine	2021	16	2833	2847	
6A3E	33883894	MVM NES mutant Nm15 in complex with CRM1-Ran-RanBP1	2018-06-15	2019-06-19	Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q.	Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.	Int J Nanomedicine	2021	16	2833	2847	
6K1S	31312404	Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors	2019-05-12	2019-06-19	Lin, H.,Wang, M.,Zhang, Y.W.,Tong, S.,Leal, R.A.,Shetty, R.,Vaddi, K.,Luengo, J.I.	Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.	Acs Med.Chem.Lett.	2019	10	1033	1038	
6A4M		Structure of urate oxidase from Bacillus subtilis 168	2018-06-20	2019-06-26	Nayab, A.,Moududee, S.A.,Shi, Y.,Jiang, Y.,Gong, Q.	Crystal Structure of Urate Oxidase from Bacillus Subtilis 168	Crystallography Reports	2019	64	1126	1133	
6A57	32257379	Structure of histone demethylase REF6 complexed with DNA	2018-06-22	2019-06-26	Tian, Z.,Li, X.,Li, M.,Wu, W.,Zhang, M.,Tang, C.,Li, Z.,Liu, Y.,Chen, Z.,Yang, M.,Ma, L.,Caba, C.,Tong, Y.,Lam, H.M.,Dai, S.,Chen, Z.	Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms.	Cell Discov	2020	6	17	17	
6JDE	31035307	crystal structure of a DNA repair protein	2019-02-01	2019-06-26	Kuang, X.,Tang, Q.,Liu, Y.P.,Yan, X.X.,Xu, W.	Crystal structure of a novel ATPase RadD from Escherichia coli.	Proteins	2019	87	791	795	
6JOP	31176489	Crystal structures of phage NrS-1 N300-dNTPs-Mg2+ complex provide molecular mechanisms for substrate specificity	2019-03-22	2019-06-26	Guo, H.,Li, M.,Wu, H.,Wang, W.,Yu, F.,He, J.	Crystal structures of phage NrS-1 N300-dNTPs-Mg2+complex provide molecular mechanisms for substrate specificity.	Biochem.Biophys.Res.Commun.	2019	515	551	557	
6JOQ	31176489	Crystal structures of phage NrS-1 N300-dNTPs-Mg2+ complex provide molecular mechanisms for substrate specificity	2019-03-22	2019-06-26	Guo, H.,Li, M.,Wu, H.,Wang, W.,Yu, F.,He, J.	Crystal structures of phage NrS-1 N300-dNTPs-Mg2+complex provide molecular mechanisms for substrate specificity.	Biochem.Biophys.Res.Commun.	2019	515	551	557	
6A6X	31267737	The crystal structure of the Mtb MazE-MazF-mt9 complex	2018-06-29	2019-07-03	Chen, R.,Tu, J.,Tan, Y.,Cai, X.,Yang, C.,Deng, X.,Su, B.,Ma, S.,Liu, X.,Ma, P.,Du, C.,Xie, W.	Structural and Biochemical Characterization of the Cognate and Heterologous Interactions of the MazEF-mt9 TA System.	Acs Infect Dis.	2019	5	1306	1316	
6INW	31101338	A Pericyclic Reaction enzyme	2018-10-28	2019-07-03	Chang, M.,Zhou, Y.,Wang, H.,Liu, Z.,Zhang, Y.,Feng, Y.	Crystal structure of the multifunctional SAM-dependent enzyme LepI provides insights into its catalytic mechanism.	Biochem.Biophys.Res.Commun.	2019	515	255	260	
6JG9	31149347	Crystal structure of AimR in complex with arbitrium peptide	2019-02-13	2019-07-03	Guan, Z.Y.,Pei, K.,Wang, J.,Cui, Y.Q.,Zhu, X.,Su, X.,Zhou, Y.B.,Zhang, D.L.,Tang, C.,Yin, P.,Liu, Z.,Zou, T.T.	Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage.	Cell Discov	2019	5	29	29	
6JJ4		Crystal structure of OsHXK6-apo form	2019-02-25	2019-07-03	He, C.,Wei, P.,Chen, J.,Wang, H.,Wan, Y.,Zhou, J.,Zhu, Y.,Huang, W.,Yin, L.	Crystal structure of OsHXK6-apo	To Be Published	0	0	0	0	
6KBS	31504793	Crystal structure of yedK in complex with ssDNA	2019-06-26	2019-07-10	Wang, N.,Bao, H.,Chen, L.,Liu, Y.,Li, Y.,Wu, B.,Huang, H.	Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.	Nucleic Acids Res.	2019	47	10388	10399	
6KBU	31504793	Crystal structure of yedK	2019-06-26	2019-07-10	Wang, N.,Bao, H.,Chen, L.,Liu, Y.,Li, Y.,Wu, B.,Huang, H.	Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.	Nucleic Acids Res.	2019	47	10388	10399	
6KBX	31504793	Crystal structure of yedK in complex with ssDNA containing abasic site	2019-06-26	2019-07-10	Wang, N.,Bao, H.,Chen, L.,Liu, Y.,Li, Y.,Wu, B.,Huang, H.	Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.	Nucleic Acids Res.	2019	47	10388	10399	
6KBZ	31504793	Crystal structure of yedK with ssDNA containing a tetrahydrofuran abasic site	2019-06-26	2019-07-10	Wang, N.,Bao, H.,Chen, L.,Liu, Y.,Li, Y.,Wu, B.,Huang, H.	Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.	Nucleic Acids Res.	2019	47	10388	10399	
6KCQ	31504793	Crystal structure of yedK with ssDNA containing an abasic site	2019-06-28	2019-07-10	Wang, N.,Bao, H.,Chen, L.,Liu, Y.,Li, Y.,Wu, B.,Huang, H.	Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.	Nucleic Acids Res.	2019	47	10388	10399	
6NNG	31043459	Tubulin-RB3_SLD-TTL in complex with compound DJ95	2019-01-15	2019-07-10	Arnst, K.E.,Wang, Y.,Lei, Z.N.,Hwang, D.J.,Kumar, G.,Ma, D.,Parke, D.N.,Chen, Q.,Yang, J.,White, S.W.,Seagroves, T.N.,Chen, Z.S.,Miller, D.D.,Li, W.	Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.	Mol.Pharmacol.	2019	96	73	89	
6O5M	31251599	Tubulin-RB3_SLD-TTL in complex with compound 10bb	2019-03-04	2019-07-10	Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,White, S.W.,Miller, D.D.,Li, W.,Li, W.	Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.	J.Med.Chem.	2019	62	6734	6750	
6O5N	31251599	Tubulin-RB3_SLD-TTL in complex with compound 10ab	2019-03-04	2019-07-10	Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,White, S.W.,Miller, D.D.,Li, W.,Li, W.	Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.	J.Med.Chem.	2019	62	6734	6750	
6O61	31251599	Tubulin-RB3_SLD-TTL in complex with compound ABI-231	2019-03-05	2019-07-10	Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,White, S.W.,Miller, D.D.,Li, W.,Li, W.	Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.	J.Med.Chem.	2019	62	6734	6750	
6J8Q	31269398	Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor WL-001	2019-01-21	2019-07-17	Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.	Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.	J.Med.Chem.	2019	62	7160	7184	
6J8R	31269398	Metallo-Beta-Lactamase VIM-2 in complex with Dual MBL/SBL Inhibitor MS01	2019-01-21	2019-07-17	Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.	Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.	J.Med.Chem.	2019	62	7160	7184	
6JN3	31269398	Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor MS05	2019-03-13	2019-07-17	Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.	Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.	J.Med.Chem.	2019	62	7160	7184	
6JN4	31269398	Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor WL-001	2019-03-13	2019-07-17	Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.	Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.	J.Med.Chem.	2019	62	7160	7184	
6JN5	31269398	Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor MS23	2019-03-13	2019-07-17	Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.	Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.	J.Med.Chem.	2019	62	7160	7184	
6JN6	31269398	Metallo-Beta-Lactamase VIM-2 in complex with Dual MBL/SBL Inhibitor MS19	2019-03-13	2019-07-17	Wang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.	Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.	J.Med.Chem.	2019	62	7160	7184	
6JZC	31324789	Structural basis of tubulin detyrosination	2019-05-01	2019-07-17	Zhou, C.,Yan, L.,Zhang, W.H.,Liu, Z.	Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer.	Nat Commun	2019	10	3212	3212	
6ACE		histone lysine desuccinylase Sirt5 in complex with succinyl peptide H3K122	2018-07-26	2019-07-24	Hang, T.R.,Chen, W.B.,Zang, J.Y.,Zhang, X.	complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H3K122	To Be Published	0	0	0	0	
6IO9	31101915	The structure of apo-UdgX	2018-10-29	2019-07-24	Tu, J.,Chen, R.,Yang, Y.,Cao, W.,Xie, W.	Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation.	Nat.Chem.Biol.	2019	15	615	622	
6ISQ	31324776	structure of Lipase mutant with oxided Cys-His-Asp catalytic triad	2018-11-18	2019-07-24	Cen, Y.,Singh, W.,Arkin, M.,Moody, T.S.,Huang, M.,Zhou, J.,Wu, Q.,Reetz, M.T.	Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution.	Nat Commun	2019	10	3198	3198	
6JUT	31244114	Crystal structure of ZAK in complex with compound 6k	2019-04-15	2019-07-24	Yang, J.,Shibu, M.A.,Kong, L.,Luo, J.,BadrealamKhan, F.,Huang, Y.,Tu, Z.C.,Yun, C.H.,Huang, C.Y.,Ding, K.,Lu, X.	Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.	J.Med.Chem.	2020	63	2114	2130	
6INF	31324778	a glycosyltransferase complex with UDP	2018-10-25	2019-07-31	Yang, T.,Zhang, J.,Ke, D.,Yang, W.,Tang, M.,Jiang, J.,Cheng, G.,Li, J.,Cheng, W.,Wei, Y.,Li, Q.,Naismith, J.H.,Zhu, X.	Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.	Nat Commun	2019	10	3214	3214	
6ING	31324778	A complex structure of H25A mutant of glycosyltransferase with UDP	2018-10-25	2019-07-31	Yang, T.,Zhang, J.,Ke, D.,Yang, W.,Tang, M.,Jiang, J.,Cheng, G.,Li, J.,Cheng, W.,Wei, Y.,Li, Q.,Naismith, J.H.,Zhu, X.	Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.	Nat Commun	2019	10	3214	3214	
6INH	31324778	A glycosyltransferase with UDP and the substrate	2018-10-25	2019-07-31	Yang, T.,Zhang, J.,Ke, D.,Yang, W.,Tang, M.,Jiang, J.,Cheng, G.,Li, J.,Cheng, W.,Wei, Y.,Li, Q.,Naismith, J.H.,Zhu, X.	Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.	Nat Commun	2019	10	3214	3214	
6INI	31324778	a glycosyltransferase complex with UDP and the product	2018-10-25	2019-07-31	Yang, T.,Zhang, J.,Ke, D.,Yang, W.,Tang, M.,Jiang, J.,Cheng, G.,Li, J.,Cheng, W.,Wei, Y.,Li, Q.,Naismith, J.H.,Zhu, X.	Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.	Nat Commun	2019	10	3214	3214	
6J4T	31318636	Crystal structure of arabidopsis ADAL complexed with IMP	2019-01-10	2019-07-31	Wu, B.,Zhang, D.,Nie, H.,Shen, S.,Li, Y.,Li, S.	Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing.	Rna Biol.	2019	16	1504	1512	
6JV3	31489163	Crystal structure of 5-hydoxylmethylcytosine containing decamer dsDNA	2019-04-15	2019-07-31	Fu, T.,Liu, L.,Yang, Q.L.,Wang, Y.,Xu, P.,Zhang, L.,Liu, S.,Dai, Q.,Ji, Q.,Xu, G.L.,He, C.,Luo, C.,Zhang, L.	Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.	Chem Sci	2019	10	7407	7417	
6JV5	31489163	Crystal structure of 5-methylcytosine containing decamer dsDNA	2019-04-15	2019-07-31	Fu, T.,Liu, L.,Yang, Q.L.,Wang, Y.,Xu, P.,Zhang, L.,Liu, S.,Dai, Q.,Ji, Q.,Xu, G.L.,He, C.,Luo, C.,Zhang, L.	Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.	Chem Sci	2019	10	7407	7417	
6IHG	31306520	N terminal domain of Mycobacterium avium complex Lon protease	2018-09-29	2019-08-07	Chen, X.,Zhang, S.,Bi, F.,Guo, C.,Feng, L.,Wang, H.,Yao, H.,Lin, D.	Crystal structure of the N domain of Lon protease from Mycobacterium avium complex.	Protein Sci.	2019	28	1720	1726	
6IHR	30868877	Crystal structure of bacterial serine phosphatase with His tag	2018-10-02	2019-08-07	Yang, T.,Liu, T.,Gan, J.,Yu, K.,Chen, K.,Xue, W.,Lan, L.,Yang, S.,Yang, C.G.	Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase.	Acs Infect Dis.	2019	5	841	850	
6IHU	30868877	Crystal structure of bacterial serine phosphatase bearing R161A mutation	2018-10-02	2019-08-07	Yang, T.,Liu, T.,Gan, J.,Yu, K.,Chen, K.,Xue, W.,Lan, L.,Yang, S.,Yang, C.G.	Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase.	Acs Infect Dis.	2019	5	841	850	
6IHV	30868877	Crystal structure of bacterial serine phosphatase bearing R161E mutation	2018-10-02	2019-08-07	Yang, T.,Liu, T.,Gan, J.,Yu, K.,Chen, K.,Xue, W.,Lan, L.,Yang, S.,Yang, C.G.	Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase.	Acs Infect Dis.	2019	5	841	850	
6IHW	30868877	Crystal structure of bacterial serine phosphatase bearing R161K mutation	2018-10-02	2019-08-07	Yang, T.,Liu, T.,Gan, J.,Yu, K.,Chen, K.,Xue, W.,Lan, L.,Yang, S.,Yang, C.G.	Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase.	Acs Infect Dis.	2019	5	841	850	
6KIJ	31504793	Crystal structure of yedK with ssDNA containing an abasic site	2019-07-18	2019-08-07	Wang, N.,Bao, H.,Chen, L.,Liu, Y.,Li, Y.,Wu, B.,Huang, H.	Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK.	Nucleic Acids Res.	2019	47	10388	10399	
6E9C		Selenomethionine Derivative Structure of A Bacterial Homolog to Human Lysosomal Transporter, Spinster	2018-07-31	2019-08-14	Zhou, F.,Yao, D.,Rao, B.,Zhang, L.,Nie, W.,Zou, Y.,Zhao, J.,,Cao, Y.	Crystal structure of a bacterial homolog to human lysosomal transporter, spinster	Sci Bull (Beijing)	2019	64	1310	1317	
6IHJ	31570835	Crystal structure of Drosophila Nxf1 NTF2 domain in complex with Nxt1/p15	2018-09-30	2019-08-14	Zhao, K.,Cheng, S.,Miao, N.,Xu, P.,Lu, X.,Zhang, Y.,Wang, M.,Ouyang, X.,Yuan, X.,Liu, W.,Lu, X.,Zhou, P.,Gu, J.,Zhang, Y.,Qiu, D.,Jin, Z.,Su, C.,Peng, C.,Wang, J.H.,Dong, M.Q.,Wan, Y.,Ma, J.,Cheng, H.,Huang, Y.,Yu, Y.	A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.	Nat.Cell Biol.	2019	21	1261	1272	
6IIH	31397067	crystal structure of mitochondrial calcium uptake 2(MICU2)	2018-10-06	2019-08-14	Wu, W.,Shen, Q.,Lei, Z.,Qiu, Z.,Li, D.,Pei, H.,Zheng, J.,Jia, Z.	The crystal structure of MICU2 provides insight into Ca2+binding and MICU1-MICU2 heterodimer formation.	Embo Rep.	2019	20	0	0	
6AGK	31860298	The structure of CH-II-77-tubulin complex	2018-08-13	2019-08-21	Chen, H.,Deng, S.,Wang, Y.,Albadari, N.,Kumar, G.,Ma, D.,Li, W.,White, S.W.,Miller, D.D.,Li, W.	Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.	J.Med.Chem.	2020	63	827	846	
6AGX		The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold	2018-08-15	2019-08-21	Xiong, B.	The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold	To be published	0	0	0	0	
6EG5		The structure of SB-1-202-tubulin complex	2018-08-18	2019-08-21	Chen, H.,Wang, Y.,Li, W.	The structure of SB-1-202/SB-2-204-tubulin complex	To Be Published	0	0	0	0	
6IEW	31570835	The crystal structure of the dNxf2 UBA domain in complex with Panoramix	2018-09-17	2019-08-21	Zhao, K.,Cheng, S.,Miao, N.,Xu, P.,Lu, X.,Zhang, Y.,Wang, M.,Ouyang, X.,Yuan, X.,Liu, W.,Lu, X.,Zhou, P.,Gu, J.,Zhang, Y.,Qiu, D.,Jin, Z.,Su, C.,Peng, C.,Wang, J.H.,Dong, M.Q.,Wan, Y.,Ma, J.,Cheng, H.,Huang, Y.,Yu, Y.	A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.	Nat.Cell Biol.	2019	21	1261	1272	
6J3B	31087527	Crystal structure of human DHODH in complex with inhibitor 1289	2019-01-04	2019-08-21	Zeng, T.,Zuo, Z.,Luo, Y.,Zhao, Y.,Yu, Y.,Chen, Q.	A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.	Febs Open Bio	2019	9	1348	1354	
6J3C	31087527	Crystal structure of human DHODH in complex with inhibitor 1291	2019-01-04	2019-08-21	Zeng, T.,Zuo, Z.,Luo, Y.,Zhao, Y.,Yu, Y.,Chen, Q.	A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.	Febs Open Bio	2019	9	1348	1354	
6J56	31371777	Crystal structure of Myosin VI CBD in complex with Tom1 MBM	2019-01-10	2019-08-21	Hu, S.,Guo, Y.,Wang, Y.,Li, Y.,Fu, T.,Zhou, Z.,Wang, Y.,Liu, J.,Pan, L.	Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering.	Nat Commun	2019	10	3459	3459	
6K9V	31369682	Crystal structure of tubulin in complex with inhibitor D64	2019-06-18	2019-08-28	Li, Y.,Yang, J.,Niu, L.,Hu, D.,Li, H.,Chen, L.,Yu, Y.,Chen, Q.	Structural insights into the design of indole derivatives as tubulin polymerization inhibitors.	Febs Lett.	2020	594	199	204	
6KKH	31405562	Crystal structure of the oxalate bound malyl-CoA lyase from Roseiflexus castenholzii	2019-07-25	2019-09-04	Tang, W.,Wang, Z.,Zhang, C.,Wang, C.,Min, Z.,Zhang, X.,Liu, D.,Shen, J.,Xu, X.	The C-terminal domain conformational switch revealed by the crystal structure of malyl-CoA lyase from Roseiflexus castenholzii.	Biochem.Biophys.Res.Commun.	2019	518	72	79	
6J73	31467269	Crystal structure of IniA from Mycobacterium smegmatis	2019-01-16	2019-09-11	Wang, M.,Guo, X.,Yang, X.,Zhang, B.,Ren, J.,Liu, A.,Ran, Y.,Yan, B.,Chen, F.,Guddat, L.W.,Hu, J.,Li, J.,Rao, Z.	Mycobacterial dynamin-like protein IniA mediates membrane fission.	Nat Commun	2019	10	3906	3906	
6AH8	32515491	Marine bacterial prolidase with promiscuous organophosphorus hydrolase activity	2018-08-17	2019-09-18	Yang, J.,Xiao, Y.Z.,Li, R.,Liu, Y.,Long, L.J.	Repurposing a bacterial prolidase for organophosphorus hydrolysis: Reshaped catalytic cavity switches substrate selectivity.	Biotechnol.Bioeng.	2020	117	2694	2702	
6IE2	32051559	Crystal structure of methyladenine demethylase	2018-09-13	2019-09-18	Tian, L.F.,Liu, Y.P.,Chen, L.,Tang, Q.,Wu, W.,Sun, W.,Chen, Z.,Yan, X.X.	Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1.	Cell Res.	2020	30	272	275	
6IE3	32051559	Crystal structure of methyladenine demethylase	2018-09-13	2019-09-18	Tian, L.F.,Liu, Y.P.,Chen, L.,Tang, Q.,Wu, W.,Sun, W.,Chen, Z.,Yan, X.X.	Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1.	Cell Res.	2020	30	272	275	
6IET	31537782	The crystal structure of TRIM66 PHD-Bromo domain	2018-09-17	2019-09-18	Chen, J.,Wang, Z.,Guo, X.,Li, F.,Wei, Q.,Chen, X.,Gong, D.,Xu, Y.,Chen, W.,Liu, Y.,Kang, J.,Shi, Y.	TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.	Nat Commun	2019	10	4273	4273	
6IEU	31537782	The structure of TRIM66 PHD-Bromo domain with unmodified H3 N terminal peptide	2018-09-17	2019-09-18	Chen, J.,Wang, Z.,Guo, X.,Li, F.,Wei, Q.,Chen, X.,Gong, D.,Xu, Y.,Chen, W.,Liu, Y.,Kang, J.,Shi, Y.	TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.	Nat Commun	2019	10	4273	4273	
6J2D	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1	2019-01-01	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6J2E	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Ebola virus-derived peptide EBOV-NP1	2019-01-01	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6J2F	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV2	2019-01-01	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6J2G	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Ebola virus-derived peptide EBOV-NP2	2019-01-01	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6J2H	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 mutant (Met52 Asp53 Leu54 deleted) in complex with Hendra virus-derived peptide HeV1	2019-01-01	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6J2I	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with H17N10 influenza-like virus-derivrd peptide H17N10-NP	2019-01-01	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6J2J	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with MERS-CoV-derived peptide MERS-CoV-S3	2019-01-01	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6K04	31461688	Crystal structure of BRD2(BD2)with ligand BY27 bound	2019-05-05	2019-09-18	Chen, D.,Lu, T.,Yan, Z.,Lu, W.,Zhou, F.,Lyu, X.,Xu, B.,Jiang, H.,Chen, K.,Luo, C.,Zhao, Y.	Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.	Eur.J.Med.Chem.	2019	182	111633	111633	
6K05	31461688	Crystal structure of BRD2(BD1)with ligand BY27 bound	2019-05-05	2019-09-18	Chen, D.,Lu, T.,Yan, Z.,Lu, W.,Zhou, F.,Lyu, X.,Xu, B.,Jiang, H.,Chen, K.,Luo, C.,Zhao, Y.	Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.	Eur.J.Med.Chem.	2019	182	111633	111633	
6K7U	31498797	Crystal structure of beta-2 microglobulin (beta2m) of Bat (Pteropus Alecto)	2019-06-08	2019-09-18	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6KMR	31636962	Crystal structure of human N6amt1-Trm112 in complex with SAM (space group P6122)	2019-08-01	2019-09-18	Li, W.,Shi, Y.,Zhang, T.,Ye, J.,Ding, J.	Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase.	Cell Discov	2019	5	51	51	
6J1V	31396224	The structure of HLA-A*3003/RT313	2018-12-29	2019-09-25	Zhu, S.,Liu, K.,Chai, Y.,Wu, Y.,Lu, D.,Xiao, W.,Cheng, H.,Zhao, Y.,Ding, C.,Lyu, J.,Lou, Y.,Gao, G.F.,Liu, W.J.	Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides.	Front Immunol	2019	10	1709	1709	
6J1W	31396224	The structure of HLA-A*3001/RT313	2018-12-29	2019-09-25	Zhu, S.,Liu, K.,Chai, Y.,Wu, Y.,Lu, D.,Xiao, W.,Cheng, H.,Zhao, Y.,Ding, C.,Lyu, J.,Lou, Y.,Gao, G.F.,Liu, W.J.	Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides.	Front Immunol	2019	10	1709	1709	
6J29	31396224	The structure of HLA-A*3003/MTB	2018-12-31	2019-09-25	Zhu, S.,Liu, K.,Chai, Y.,Wu, Y.,Lu, D.,Xiao, W.,Cheng, H.,Zhao, Y.,Ding, C.,Lyu, J.,Lou, Y.,Gao, G.F.,Liu, W.J.	Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides.	Front Immunol	2019	10	1709	1709	
6J2A	31396224	The structure of HLA-A*3003/NP44	2018-12-31	2019-09-25	Zhu, S.,Liu, K.,Chai, Y.,Wu, Y.,Lu, D.,Xiao, W.,Cheng, H.,Zhao, Y.,Ding, C.,Lyu, J.,Lou, Y.,Gao, G.F.,Liu, W.J.	Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides.	Front Immunol	2019	10	1709	1709	
6J68	31486770	Structure of KIBRA and LATS1 Complex	2019-01-14	2019-09-25	Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M.	Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.	Elife	2019	8	0	0	
6JJW	31486770	Crystal Structure of KIBRA and PTPN14 complex	2019-02-27	2019-09-25	Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M.	Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.	Elife	2019	8	0	0	
6JJX	31486770	Crystal Structure of KIBRA and Angiomotin complex	2019-02-27	2019-09-25	Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M.	Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.	Elife	2019	8	0	0	
6JJY	31486770	Crystal Structure of KIBRA and beta-Dystroglycan	2019-02-27	2019-09-25	Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M.	Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.	Elife	2019	8	0	0	
6JK0	31486770	Crystal Structure of YAP1 and Dendrin complex	2019-02-27	2019-09-25	Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M.	Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.	Elife	2019	8	0	0	
6JK1	31486770	Crystal Structure of YAP1 and Dendrin complex 2	2019-02-27	2019-09-25	Lin, Z.,Yang, Z.,Xie, R.,Ji, Z.,Guan, K.,Zhang, M.	Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity.	Elife	2019	8	0	0	
6K3Z	31603896	Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM)	2019-05-22	2019-09-25	Chen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q.	Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.	Plos Biol.	2019	17	0	0	
6K4P	31603896	Crystal structure of xCas9 in complex with sgRNA and DNA (TGG PAM)	2019-05-25	2019-09-25	Chen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q.	Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.	Plos Biol.	2019	17	0	0	
6K4Q	31603896	Crystal structure of xCas9 in complex with sgRNA and DNA (CGG PAM)	2019-05-26	2019-09-25	Chen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q.	Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.	Plos Biol.	2019	17	0	0	
6K4S	31603896	Crystal structure of xCas9 in complex with sgRNA and DNA (TGC PAM)	2019-05-26	2019-09-25	Chen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q.	Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.	Plos Biol.	2019	17	0	0	
6K4U	31603896	Crystal structure of xCas9 in complex with sgRNA and DNA (TGA PAM)	2019-05-27	2019-09-25	Chen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q.	Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.	Plos Biol.	2019	17	0	0	
6K57	31603896	Crystal structure of dCas9 in complex with sgRNA and DNA (CGA PAM)	2019-05-28	2019-09-25	Chen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q.	Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.	Plos Biol.	2019	17	0	0	
6K62	31419523	Crystal structure of Xanthomonas PcrK	2019-05-31	2019-09-25	Chen, P.,Jiao, X.,Zhang, Y.,Wu, L.,Tang, D.J.,Li, P.,Chen, X.,Chao, D.,Tang, J.L.,Ming, Z.	The crystal structure of the phytopathogenic bacterial sensor PcrK reveals different cytokinin recognition mechanism from the plant sensor AHK4.	J.Struct.Biol.	2019	208	69	76	
6KDF	31515270	Crystal structure of the alpha beta heterodimer of human IDH3 in APO form.	2019-07-02	2019-09-25	Sun, P.,Ma, T.,Zhang, T.,Zhu, H.,Zhang, J.,Liu, Y.,Ding, J.	Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase.	J.Biol.Chem.	2019	294	16214	16227	
6KET		Flavin-utilizing Monooxygenase (OX) Domain of Hybrid Polyketide/Non-Ribosomal Peptide Synthetase	2019-07-05	2019-09-25	Tian, Q.W.,Jiang, T.	Structure Insights into the Molecular Mechanism of Two Tailoring Domains of Hybrid Polyketide/Non-Ribosomal Peptide Synthetase	To Be Published	0	0	0	0	
6KFR		Amino-transferase (AMT) Domain - Arg Complex of Hybrid Polyketide/Non-Ribosomal Peptide Synthetase	2019-07-08	2019-09-25	Tian, Q.W.,Jiang, T.	Structure Insights into the Molecular Mechanism of Two Tailoring Domains of Hybrid Polyketide/Non-Ribosomal Peptide Synthetase	To Be Published	0	0	0	0	
6KM7	31544921	The structural basis for the internal interaction in RBBP5	2019-07-31	2019-10-02	Han, J.,Li, T.,Li, Y.,Li, M.,Wang, X.,Peng, C.,Su, C.,Li, N.,Li, Y.,Xu, Y.,Chen, Y.	The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.	Nucleic Acids Res.	2019	47	10426	10438	
6III		Crystal structure of an uncharacterized protein	2018-10-06	2019-10-09	Li, B.	Crystal structure of an uncharacterized protein	To Be Published	0	0	0	0	
6JPS	31497803	Human H chain ferritin mutant-MBP	2019-03-27	2019-10-09	Wang, Y.,Chen, H.,Zang, J.,Zhang, X.,Zhao, G.	Re-designing ferritin nanocages for mercuric ion detection.	Analyst	2019	144	5890	5897	
6K00		Crystal structure A of ceNAP1-H2A-H2B complex	2019-05-05	2019-10-09	Liu, Y.R.	Crystal structure of xlH2A-H2B	Structure	2019	0	0	0	
6K01		Crystal structure of xH2A-H2B	2019-05-05	2019-10-09	Liu, Y.R.	Crystal structure of xlH2A-H2B	Structure	2019	0	0	0	
6K02		Crystal structure of ceNAP1 core	2019-05-05	2019-10-09	Liu, Y.R.	Crystal structure of xlH2A-H2B	Structure	2019	0	0	0	
6K03		Crystal structure of ceH2A-H2B	2019-05-05	2019-10-09	Liu, Y.R.	Crystal structure of xlH2A-H2B	Structure	2019	0	0	0	
6K09		Crystal structure B of ceNAP1-H2A-H2B complex	2019-05-05	2019-10-09	Liu, Y.R.	Crystal structure of xlH2A-H2B	Structure	2019	0	0	0	
6K0C		Crystal structure of ceNAP1-H2A.Z-H2B complex	2019-05-05	2019-10-09	Liu, Y.R.	Crystal structure of xlH2A-H2B	Structure	2019	0	0	0	
6JIO	31202993	Human LXR-beta in complex with a ligand	2019-02-22	2019-10-16	Zhang, Z.,Chen, H.,Chen, Z.,Ding, P.,Ju, Y.,Gu, Q.,Xu, J.,Zhou, H.	Identify liver X receptor beta modulator building blocks by developing a fluorescence polarization-based competition assay.	Eur.J.Med.Chem.	2019	178	458	467	
6JIW	31129210	Crystal structure of S. aureus CntK with C72S mutation	2019-02-23	2019-10-16	Luo, S.,Ju, Y.,Zhou, J.,Gu, Q.,Xu, J.,Zhou, H.	Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus.	Int.J.Biol.Macromol.	2019	135	725	733	
6JM5	31624125	Crystal structure of TBC1D23 C terminal domain	2019-03-07	2019-10-16	Huang, W.,Liu, Z.,Yang, F.,Zhou, H.,Yong, X.,Yang, X.,Zhou, Y.,Xue, L.,Zhang, Y.,Liu, D.,Meng, W.,Zhang, W.,Zhang, X.,Shen, X.,Sun, Q.,Li, L.,Ma, C.,Wei, Y.,Billadeau, D.D.,Mo, X.,Jia, D.	Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.	Proc.Natl.Acad.Sci.USA	2019	116	22598	22608	
6K12	31585506	Babesia microti lactate dehydrogenase apo form (BmLDH)	2019-05-09	2019-10-16	Yu, L.,Shen, Z.,Liu, Q.,Zhan, X.,Luo, X.,An, X.,Sun, Y.,Li, M.,Wang, S.,Nie, Z.,Ao, Y.,Zhao, Y.,Peng, G.,Mamoun, C.B.,He, L.,Zhao, J.	Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.	Faseb J.	2019	33	13669	13682	
6K13	31585506	Crystal Structure Basis for BmLDH Complex	2019-05-09	2019-10-16	Yu, L.,Shen, Z.,Liu, Q.,Zhan, X.,Luo, X.,An, X.,Sun, Y.,Li, M.,Wang, S.,Nie, Z.,Ao, Y.,Zhao, Y.,Peng, G.,Mamoun, C.B.,He, L.,Zhao, J.	Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.	Faseb J.	2019	33	13669	13682	
6IM6	31099559	Crystal structure of PDE4D complexed with a novel inhibitor	2018-10-22	2019-10-23	Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.	Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.	J.Med.Chem.	2019	62	5579	5593	
6IMB	31099559	Crystal structure of PDE4D complexed with a novel inhibitor	2018-10-22	2019-10-23	Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.	Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.	J.Med.Chem.	2019	62	5579	5593	
6IMD	31099559	Crystal structure of PDE4D complexed with a novel inhibitor	2018-10-22	2019-10-23	Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.	Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.	J.Med.Chem.	2019	62	5579	5593	
6IMI	31099559	Crystal structure of PDE4D complexed with a novel inhibitor	2018-10-23	2019-10-23	Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.	Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.	J.Med.Chem.	2019	62	5579	5593	
6IMO	31099559	Crystal structure of PDE4D complexed with a novel inhibitor	2018-10-23	2019-10-23	Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.	Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.	J.Med.Chem.	2019	62	5579	5593	
6INK	31099559	Crystal structure of PDE4D complexed with a novel inhibitor	2018-10-25	2019-10-23	Zhang, X.,Dong, G.,Li, H.,Chen, W.,Li, J.,Feng, C.,Gu, Z.,Zhu, F.,Zhang, R.,Li, M.,Tang, W.,Liu, H.,Xu, Y.	Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.	J.Med.Chem.	2019	62	5579	5593	
6IS8	31611704	Crystal structure of ZmMoc1 D115N mutant in complex with Holliday junction	2018-11-15	2019-10-23	Lin, H.,Zhang, D.,Zuo, K.,Yuan, C.,Li, J.,Huang, M.,Lin, Z.	Structural basis of sequence-specific Holliday junction cleavage by MOC1.	Nat.Chem.Biol.	2019	15	1241	1248	
6ITJ	31335138	Crystal structure of FGFR1 kinase domain in complex with compound 3	2018-11-23	2019-10-23	Wang, Y.,Dai, Y.,Wu, X.,Li, F.,Liu, B.,Li, C.,Liu, Q.,Zhou, Y.,Wang, B.,Zhu, M.,Cui, R.,Tan, X.,Xiong, Z.,Liu, J.,Tan, M.,Xu, Y.,Geng, M.,Jiang, H.,Liu, H.,Ai, J.,Zheng, M.	Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.	J.Med.Chem.	2019	62	7473	7488	
6IUO	31335138	Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor	2018-11-29	2019-10-23	Wang, Y.,Dai, Y.,Wu, X.,Li, F.,Liu, B.,Li, C.,Liu, Q.,Zhou, Y.,Wang, B.,Zhu, M.,Cui, R.,Tan, X.,Xiong, Z.,Liu, J.,Tan, M.,Xu, Y.,Geng, M.,Jiang, H.,Liu, H.,Ai, J.,Zheng, M.	Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.	J.Med.Chem.	2019	62	7473	7488	
6J6M	31381333	Co-crystal structure of BTK kinase domain with Zanubrutinib	2019-01-15	2019-10-23	Guo, Y.,Liu, Y.,Hu, N.,Yu, D.,Zhou, C.,Shi, G.,Zhang, B.,Wei, M.,Liu, J.,Luo, L.,Tang, Z.,Song, H.,Guo, Y.,Liu, X.,Su, D.,Zhang, S.,Song, X.,Zhou, X.,Hong, Y.,Chen, S.,Cheng, Z.,Young, S.,Wei, Q.,Wang, H.,Wang, Q.,Lv, L.,Wang, F.,Xu, H.,Sun, H.,Xing, H.,Li, N.,Zhang, W.,Wang, Z.,Liu, G.,Sun, Z.,Zhou, D.,Li, W.,Liu, L.,Wang, L.,Wang, Z.	Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.	J.Med.Chem.	2019	62	7923	7940	
6JRF	31611704	Crystal structure of ZmMoc1-Holliday junction Complex in the presence of Calcium	2019-04-03	2019-10-23	Lin, H.,Zhang, D.,Zuo, K.,Yuan, C.,Li, J.,Huang, M.,Lin, Z.	Structural basis of sequence-specific Holliday junction cleavage by MOC1.	Nat.Chem.Biol.	2019	15	1241	1248	
6KKB	31655060	A novel agonist of THRb	2019-07-24	2019-10-23	Yao, B.,Wei, Y.,Zhang, S.,Tian, S.,Xu, S.,Wang, R.,Zheng, W.,Li, Y.	Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.	Iscience	2019	20	489	496	
6KNU	31655060	THRb mutation with a novel agonist	2019-08-07	2019-10-23	Yao, B.,Wei, Y.,Zhang, S.,Tian, S.,Xu, S.,Wang, R.,Zheng, W.,Li, Y.	Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.	Iscience	2019	20	489	496	
6KNZ	31628188	Crystal structure of T2R-TTL-KXO1 complex	2019-08-07	2019-10-23	Niu, L.,Yang, J.,Yan, W.,Yu, Y.,Zheng, Y.,Ye, H.,Chen, Q.,Chen, L.	Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity.	J.Biol.Chem.	2019	294	18099	18108	
6KMB	31711754	Crystal structure of Sth1 bromodomain	2019-07-31	2019-10-30	Chen, G.,Li, W.,Yan, F.,Wang, D.,Chen, Y.	The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex.	Structure	2020	28	111	0	
6KZ9	31619765	Crystal structure of plant Phospholipase D alpha	2019-09-23	2019-10-30	Li, J.,Yu, F.,Guo, H.,Xiong, R.,Zhang, W.,He, F.,Zhang, M.,Zhang, P.	Crystal structure of plant PLD alpha 1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.	Cell Res.	2020	30	61	69	
6R48	31645759	Crystal structure of LPOR (Synechocystis) complexed with NADPH at 1.87A resolution.	2019-03-22	2019-10-30	Zhang, S.,Heyes, D.J.,Feng, L.,Sun, W.,Johannissen, L.O.,Liu, H.,Levy, C.W.,Li, X.,Yang, J.,Yu, X.,Lin, M.,Hardman, S.J.O.,Hoeven, R.,Sakuma, M.,Hay, S.,Leys, D.,Rao, Z.,Zhou, A.,Cheng, Q.,Scrutton, N.S.	Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis.	Nature	2019	574	722	725	
6J04	31666698	Crystal structure of full length human LC3B delta G120 mutant (2_125)	2018-12-21	2019-11-06	Li, Z.Y.,Wang, C.,Wang, Z.Y.,Zhu, C.G.,Li, J.,Sha, T.,Ma, L.X.,Gao, C.,Yang, Y.,Sun, Y.M.,Wang, J.,Sun, X.L.,Lu, C.Q.,Difiglia, M.,Mein, Y.,Ding, C.,Luo, S.Q.,Dang, Y.J.,Ding, Y.,Fei, Y.Y.,Lu, B.X.	Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds	Nature	2019	575	203	209	
6JDQ	31668930	Crystal structure of Nme1Cas9 in complex with sgRNA	2019-02-02	2019-11-06	Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y.	Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.	Mol.Cell	2019	76	938	0	
6JDV	31668930	Crystal structure of Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in catalytic state	2019-02-02	2019-11-06	Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y.	Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.	Mol.Cell	2019	76	938	0	
6JE3	31668930	Crystal structure of Nme2Cas9 in complex with sgRNA and target DNA (AGGCCC PAM) with 5 nt overhang	2019-02-03	2019-11-06	Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y.	Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.	Mol.Cell	2019	76	938	0	
6JE4	31668930	Crystal structure of Nme1Cas9-sgRNA-dsDNA dimer mediated by double protein inhibitor AcrIIC3 monomers	2019-02-04	2019-11-06	Sun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y.	Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.	Mol.Cell	2019	76	938	0	
6K7T	31498797	Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1--human beta-2 microglobulin	2019-06-08	2019-11-06	Lu, D.,Liu, K.,Zhang, D.,Yue, C.,Lu, Q.,Cheng, H.,Wang, L.,Chai, Y.,Qi, J.,Wang, L.F.,Gao, G.F.,Liu, W.J.	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.	Plos Biol.	2019	17	0	0	
6IR2	34562299	Crystal structure of red fluorescent protein mCherry complexed with the nanobody LaM2 at 1.4 Angstron resolution	2018-11-09	2019-11-13	Wang, Z.,Li, L.,Hu, R.,Zhong, P.,Zhang, Y.,Cheng, S.,Jiang, H.,Liu, R.,Ding, Y.	Structural insights into the binding of nanobodies LaM2 and LaM4 to the red fluorescent protein mCherry.	Protein Sci.	2021	30	2298	2309	
6JFK	31664033	GDP bound Mitofusin2 (MFN2)	2019-02-10	2019-11-13	Li, Y.J.,Cao, Y.L.,Feng, J.X.,Qi, Y.,Meng, S.,Yang, J.F.,Zhong, Y.T.,Kang, S.,Chen, X.,Lan, L.,Luo, L.,Yu, B.,Chen, S.,Chan, D.C.,Hu, J.,Gao, S.	Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.	Nat Commun	2019	10	4914	4914	
6K8P	32493959	Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete Phytophthora capsici.	2019-06-13	2019-11-13	Yang, C.,Li, J.,Huang, Z.,Zhang, X.,Gao, X.,Zhu, C.,Morris, P.F.,Zhang, X.	Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.	Sci Rep	2020	10	9051	9051	
6KNK	31634470	Crystal structure of SbnH in complex with citryl-diaminoethane	2019-08-05	2019-11-13	Tang, J.,Ju, Y.,Gu, Q.,Xu, J.,Zhou, H.	Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis.	J.Mol.Biol.	2019	431	4868	4881	
6KY8	31662460	Crystal structure of ASFV dUTPase	2019-09-17	2019-11-13	Li, C.,Chai, Y.,Song, H.,Weng, C.,Qi, J.,Sun, Y.,Gao, G.F.	Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target.	Mbio	2019	10	0	0	
6KY9	31662460	Crystal structure of ASFV dUTPase and UMP complex	2019-09-17	2019-11-13	Li, C.,Chai, Y.,Song, H.,Weng, C.,Qi, J.,Sun, Y.,Gao, G.F.	Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target.	Mbio	2019	10	0	0	
6KZ6	31748385	Crystal structure of ASFV dUTPase	2019-09-23	2019-11-13	Li, G.,Wang, C.,Yang, M.,Cao, L.,Fu, D.,Liu, X.,Sun, D.,Chen, C.,Wang, Y.,Jia, Z.,Yang, C.,Guo, Y.,Rao, Z.	Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family.	J.Virol.	2020	94	0	0	
6KZ8	31619765	Crystal structure of plant Phospholipase D alpha complex with phosphatidic acid	2019-09-23	2019-11-13	Li, J.,Yu, F.,Guo, H.,Xiong, R.,Zhang, W.,He, F.,Zhang, M.,Zhang, P.	Crystal structure of plant PLD alpha 1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D.	Cell Res.	2020	30	61	69	
6N47	31714738	The structure of SB-2-204-tubulin complex	2018-11-17	2019-11-13	Arnst, K.E.,Banerjee, S.,Wang, Y.,Chen, H.,Li, Y.,Yang, L.,Li, W.,Miller, D.D.,Li, W.	X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors.	Acs Chem.Biol.	2019	14	2810	2821	
6KI1	31712753	The transmembrane domain of a cyanobacterium bicarbonate transporter BicA	2019-07-17	2019-11-20	Wang, C.,Sun, B.,Zhang, X.,Huang, X.,Zhang, M.,Guo, H.,Chen, X.,Huang, F.,Chen, T.,Mi, H.,Yu, F.,Liu, L.N.,Zhang, P.	Structural mechanism of the active bicarbonate transporter from cyanobacteria.	Nat.Plants	2019	5	1184	1193	
6KI2	31712753	The STAS domain of cyanobacteria bicarbonate transporter BicA	2019-07-17	2019-11-20	Wang, C.,Sun, B.,Zhang, X.,Huang, X.,Zhang, M.,Guo, H.,Chen, X.,Huang, F.,Chen, T.,Mi, H.,Yu, F.,Liu, L.N.,Zhang, P.	Structural mechanism of the active bicarbonate transporter from cyanobacteria.	Nat.Plants	2019	5	1184	1193	
6KVI	33404544	Crystal structure of UDP-SrUGT76G1	2019-09-04	2019-11-20	Liu, Z.,Li, J.,Sun, Y.,Zhang, P.,Wang, Y.	Structural Insights into the Catalytic Mechanism of a Plant Diterpene Glycosyltransferase SrUGT76G1.	Plant Commun.	2020	1	100004	100004	
6KVJ	33404544	Crystal structure of UDPX-SrUGT76G1	2019-09-04	2019-11-20	Liu, Z.,Li, J.,Sun, Y.,Zhang, P.,Wang, Y.	Structural Insights into the Catalytic Mechanism of a Plant Diterpene Glycosyltransferase SrUGT76G1.	Plant Commun.	2020	1	100004	100004	
6KVK	33404544	Crystal structure of UDP-Sm-SrUGT76G1	2019-09-04	2019-11-20	Liu, Z.,Li, J.,Sun, Y.,Zhang, P.,Wang, Y.	Structural Insights into the Catalytic Mechanism of a Plant Diterpene Glycosyltransferase SrUGT76G1.	Plant Commun.	2020	1	100004	100004	
6KVL	33404544	Crystal structure of UDP-RebB-SrUGT76G1	2019-09-04	2019-11-20	Liu, Z.,Li, J.,Sun, Y.,Zhang, P.,Wang, Y.	Structural Insights into the Catalytic Mechanism of a Plant Diterpene Glycosyltransferase SrUGT76G1.	Plant Commun.	2020	1	100004	100004	
6L6L	31723028	Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements	2019-10-29	2019-11-20	Jiang, L.,Dai, S.,Li, J.,Liang, X.,Qu, L.,Chen, X.,Guo, M.,Chen, Z.,Chen, L.,Wei, H.,Chen, Y.	Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements.	J.Biol.Chem.	2019	294	19795	19803	
6L6Q	31723028	Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements	2019-10-29	2019-11-20	Jiang, L.,Dai, S.,Li, J.,Liang, X.,Qu, L.,Chen, X.,Guo, M.,Chen, Z.,Chen, L.,Wei, H.,Chen, Y.	Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements.	J.Biol.Chem.	2019	294	19795	19803	
6IDB	31747596	Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) with 6'SLN	2018-09-09	2019-11-27	Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin.	Cell Rep	2019	29	2217	0	
6IDZ	31747596	Crystal structure of H7 hemagglutinin mutant H7-SVTQ ( A138S, P221T, L226Q) with 3'SLN	2018-09-12	2019-11-27	Xu, Y.,Peng, R.,Zhang, W.,Qi, J.,Song, H.,Liu, S.,Wang, H.,Wang, M.,Xiao, H.,Fu, L.,Fan, Z.,Bi, Y.,Yan, J.,Shi, Y.,Gao, G.F.	Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin.	Cell Rep	2019	29	2217	0	
6JIP	31713614	Crystal structure of Streptococcus pneumoniae SP_0782 (residues 7-79) in complex with single-stranded DNA dT6	2019-02-22	2019-11-27	Li, S.,Lu, G.,Fang, X.,Ramelot, T.A.,Kennedy, M.A.,Zhou, X.,Gong, P.,Zhang, X.,Liu, M.,Zhu, J.,Yang, Y.	Structural insight into the length-dependent binding of ssDNA by SP_0782 from Streptococcus pneumoniae, reveals a divergence in the DNA-binding interface of PC4-like proteins.	Nucleic Acids Res.	2020	48	432	444	
6JIQ	31713614	Crystal structure of Streptococcus pneumoniae SP_0782 (residues 7-79) in complex with single-stranded DNA dT6	2019-02-22	2019-11-27	Li, S.,Lu, G.,Fang, X.,Ramelot, T.A.,Kennedy, M.A.,Zhou, X.,Gong, P.,Zhang, X.,Liu, M.,Zhu, J.,Yang, Y.	Structural insight into the length-dependent binding of ssDNA by SP_0782 from Streptococcus pneumoniae, reveals a divergence in the DNA-binding interface of PC4-like proteins.	Nucleic Acids Res.	2020	48	432	444	
6KMJ	31711754	Crystal structure of Sth1 bromodomain in complex with H3K14Ac	2019-07-31	2019-11-27	Chen, G.,Li, W.,Yan, F.,Wang, D.,Chen, Y.	The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex.	Structure	2020	28	111	0	
6JBR	31455720	Tps1/UDP/T6P complex	2019-01-26	2019-12-04	Wang, S.,Zhao, Y.,Yi, L.,Shen, M.,Wang, C.,Zhang, X.,Yang, J.,Peng, Y.L.,Wang, D.,Liu, J.	Crystal structures of Magnaporthe oryzae trehalose-6-phosphate synthase (MoTps1) suggest a model for catalytic process of Tps1.	Biochem.J.	2019	476	3227	3240	
6JD5	31758528	ATPase	2019-01-31	2019-12-04	Wang, S.,Zhou, K.,Yang, X.,Zhang, B.,Zhao, Y.,Xiao, Y.,Yang, X.,Yang, H.,Guddat, L.W.,Li, J.,Rao, Z.	Structural insights into substrate recognition by the type VII secretion system.	Protein Cell	2020	11	124	137	
6KYH	31879129	Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas	2019-09-18	2019-12-04	Cai, Q.,Hosokawa, T.,Zeng, M.,Hayashi, Y.,Zhang, M.	Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.	Structure	2020	28	290	0	
6IX2	35229602	Structure of the A214C/A250I mutant of an epoxide hydrolase from Aspergillus usamii E001 (AuEH2) at 1.48 Angstroms resolution	2018-12-09	2019-12-11	Hu, D.,Hu, B.C.,Hou, X.D.,Zhang, D.,Lei, Y.Q.,Rao, Y.J.,Wu, M.C.	Structure-Guided Regulation in the Enantioselectivity of an Epoxide Hydrolase to Produce Enantiomeric Monosubstituted Epoxides and Vicinal Diols via Kinetic Resolution.	Org.Lett.	2022	24	1757	1761	
6IX4	33316339	Structure of an epoxide hydrolase from Aspergillus usamii E001 (AuEH2) at 1.51 Angstroms resolution	2018-12-09	2019-12-11	Hu, D.,Hu, B.C.,Wen, Z.,Zhang, D.,Liu, Y.Y.,Zang, J.,Wu, M.C.	Nearly perfect kinetic resolution of racemic o-nitrostyrene oxide by AuEH2, a microsomal epoxide hydrolase from Aspergillus usamii, with high enantio- and regio-selectivity.	Int.J.Biol.Macromol.	2021	169	1	7	
6JWP	31579828	crystal structure of EGOC	2019-04-21	2019-12-11	Zhang, T.,Peli-Gulli, M.P.,Zhang, Z.,Tang, X.,Ye, J.,De Virgilio, C.,Ding, J.	Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases.	Sci Adv	2019	5	0	0	
6K07	31796627	Crystal structure of REV7(R124A) in complex with a Shieldin3 fragment	2019-05-05	2019-12-11	Dai, Y.,Zhang, F.,Wang, L.,Shan, S.,Gong, Z.,Zhou, Z.	Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair.	J.Biol.Chem.	2020	295	250	262	
6K08	31796627	Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment	2019-05-05	2019-12-11	Dai, Y.,Zhang, F.,Wang, L.,Shan, S.,Gong, Z.,Zhou, Z.	Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair.	J.Biol.Chem.	2020	295	250	262	
6IYG		The Structure of Maltooligosaccharide-forming Amylase from Pseudomonas saccharophila STB07 with Maltotetraose	2018-12-15	2019-12-18	Zhang, Z.Q.,Ban, X.F.,Li, Z.F.,Jin, T.C.,Li, Y.L.,Gu, Z.B.,Li, C.M.,Shang, Y.H.	Maltotetraose-forming amylase from Pseudomonas saccharophila STB07	To Be Published	0	0	0	0	
6J0U	31777147	Crystal Structure of the acyltransferase domain from the third module of the ansamitocin polyketide synthase	2018-12-26	2019-12-18	Zhang, F.,Ji, H.,Ali, I.,Deng, Z.,Bai, L.,Zheng, J.	Structural and Biochemical Insight into the Recruitment of Acyl Carrier Protein-Linked Extender Units in Ansamitocin Biosynthesis.	Chembiochem	2020	21	1309	1314	
6IKM	31682834	Crystal structure of SpuE-Spermidine in complex with ScFv5	2018-10-16	2019-12-25	Zhang, Y.,Sun, X.,Qian, Y.,Yi, H.,Song, K.,Zhu, H.,Zonta, F.,Chen, W.,Ji, Q.,Miersch, S.,Sidhu, S.S.,Wu, D.	A Potent Anti-SpuE Antibody Allosterically Inhibits Type III Secretion System and Attenuates Virulence of Pseudomonas Aeruginosa.	J.Mol.Biol.	2019	431	4882	4896	
6IZC	32179166	Crystal structure of the chromosome-encoded beta-lactamase of Vibrio parahaemolyticus	2018-12-19	2019-12-25	Li, P.,Liu, C.,Li, B.,Ma, Q.	Structural analysis of the CARB beta-lactamase from Vibrio parahaemolyticus facilitates application of the beta-lactam/ beta-lactamase inhibitor therapy.	Biochimie	2020	0	213	222	
6IZD	32179166	Crystal structure of the chromosome-encoded beta-lactamase mutant R168H/M221I of Vibrio parahaemolyticus	2018-12-19	2019-12-25	Li, P.,Liu, C.,Li, B.,Ma, Q.	Structural analysis of the CARB beta-lactamase from Vibrio parahaemolyticus facilitates application of the beta-lactam/ beta-lactamase inhibitor therapy.	Biochimie	2020	0	213	222	
6KD3		Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete Phytophthora capsici.	2019-06-30	2019-12-25	Yang, C.C.,Zhang, X.G.	Structural and catalytic analysis of two diverse uridine phosphorylases in the oomycete Phytophthora capsici.	To be published	0	0	0	0	
6INY		Crystal structure of an uncharacterized protein	2018-10-29	2020-01-01	Li, B.	Crystal structure of an uncharacterized protein	To Be Published	0	0	0	0	
6IW7		structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease	2018-12-04	2020-01-01	Bao, R.,Luo, Y.F.,Zhu, Y.B.,Yang, Y.,Yang, T.	structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease	To Be Published	0	0	0	0	
6J1Q	31023008	Crystal structure of Candida Antarctica Lipase B mutant - RS	2018-12-29	2020-01-01	Xu, J.,Cen, Y.,Singh, W.,Fan, J.,Wu, L.,Lin, X.,Zhou, J.,Huang, M.,Reetz, M.T.,Wu, Q.	Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters.	J.Am.Chem.Soc.	2019	141	7934	7945	
6J1R	31023008	Crystal structure of Candida Antarctica Lipase B mutant - RR	2018-12-29	2020-01-01	Xu, J.,Cen, Y.,Singh, W.,Fan, J.,Wu, L.,Lin, X.,Zhou, J.,Huang, M.,Reetz, M.T.,Wu, Q.	Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters.	J.Am.Chem.Soc.	2019	141	7934	7945	
6J1S	31023008	Crystal structure of Candida Antarctica Lipase B mutant - SS	2018-12-29	2020-01-01	Xu, J.,Cen, Y.,Singh, W.,Fan, J.,Wu, L.,Lin, X.,Zhou, J.,Huang, M.,Reetz, M.T.,Wu, Q.	Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters.	J.Am.Chem.Soc.	2019	141	7934	7945	
6JIF	31485690	Crystal Structures of Branched-Chain Aminotransferase from Pseudomonas sp. UW4	2019-02-21	2020-01-01	Zheng, X.,Cui, Y.,Li, T.,Li, R.,Guo, L.,Li, D.,Wu, B.	Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids.	Appl.Microbiol.Biotechnol.	2019	103	8051	8062	
6L1W	31914396	Zinc-finger Antiviral Protein (ZAP) bound to RNA	2019-09-30	2020-01-01	Luo, X.,Wang, X.,Gao, Y.,Zhu, J.,Liu, S.,Gao, G.,Gao, P.	Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein.	Cell Rep	2020	30	46	0	
6LAS	31844059	the wildtype SAM-VI riboswitch bound to SAM	2019-11-13	2020-01-01	Sun, A.,Gasser, C.,Li, F.,Chen, H.,Mair, S.,Krasheninina, O.,Micura, R.,Ren, A.	SAM-VI riboswitch structure and signature for ligand discrimination.	Nat Commun	2019	10	5728	5728	
6LAU	31844059	the wildtype SAM-VI riboswitch bound to SAH	2019-11-13	2020-01-01	Sun, A.,Gasser, C.,Li, F.,Chen, H.,Mair, S.,Krasheninina, O.,Micura, R.,Ren, A.	SAM-VI riboswitch structure and signature for ligand discrimination.	Nat Commun	2019	10	5728	5728	
6LAX	31844059	the mutant SAM-VI riboswitch (U6C) bound to SAM	2019-11-13	2020-01-01	Sun, A.,Gasser, C.,Li, F.,Chen, H.,Mair, S.,Krasheninina, O.,Micura, R.,Ren, A.	SAM-VI riboswitch structure and signature for ligand discrimination.	Nat Commun	2019	10	5728	5728	
6LLB	32552320	Crystal structure of mpy-RNase J (mutant S247A), an archaeal RNase J from Methanolobus psychrophilus R15, in complex with 6 nt RNA	2019-12-22	2020-01-01	Li, J.,Hou, Y.,Gu, X.,Yue, L.,Guo, L.,Li, D.,Dong, X.	A newly identified duplex RNA unwinding activity of archaeal RNase J depends on processive exoribonucleolysis coupled steric occlusion by its structural archaeal loops.	Rna Biol.	2020	17	1480	1491	
6J3A		Structure of LmbA2991HD	2019-01-04	2020-01-15	Song, Y.	Structure of LmbA2991HD	To Be Published	0	0	0	0	
6J4E		Crystal structure of the AtWRKY1 domain	2019-01-08	2020-01-15	Xu, Y.P.,Xu, H.,Wang, B.,Su, X.D.	Crystal structure of the AtWRKY1 domain	To Be Published	0	0	0	0	
6J4F		Crystal structure of the AtWRKY2 domain	2019-01-08	2020-01-15	Xu, Y.P.,Xu, H.,Wang, B.,Su, X.D.	Crystal structure of the AtWRKY2 domain	To Be Published	0	0	0	0	
6J4G		Crystal structure of the AtWRKY33 domain	2019-01-08	2020-01-15	Xu, Y.P.,Xu, H.,Wang, B.,Su, X.D.	Crystal structure of the N-terminal DNA binding domain of AtWRKY33	To Be Published	0	0	0	0	
6JV0	31914412	Crystal Structure of N-terminal domain of ArgZ, bound to Product, an arginine dihydrolase from the Ornithine-Ammonia Cycle in Cyanobacteria	2019-04-15	2020-01-15	Zhuang, N.,Zhang, H.,Li, L.,Wu, X.,Yang, C.,Zhang, Y.	Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a ""bond rotation"" catalytic mechanism.	J.Biol.Chem.	2020	295	2113	2124	
6JV1	31914412	Crystal Structure of N-terminal domain of ArgZ, C264S mutant, bound to Substrate, an arginine dihydrolase from the Ornithine-Ammonia Cycle in Cyanobacteria	2019-04-15	2020-01-15	Zhuang, N.,Zhang, H.,Li, L.,Wu, X.,Yang, C.,Zhang, Y.	Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a ""bond rotation"" catalytic mechanism.	J.Biol.Chem.	2020	295	2113	2124	
6KR4	31924785	Crystal structure of the liprin-alpha3_SAM123/LAR_D1D2 complex	2019-08-20	2020-01-15	Xie, X.,Luo, L.,Liang, M.,Zhang, W.,Zhang, T.,Yu, C.,Wei, Z.	Structural basis of liprin-alpha-promoted LAR-RPTP clustering for modulation of phosphatase activity.	Nat Commun	2020	11	169	169	
6KZJ	31889000	Crystal structure of Ankyrin B/NdeL1 complex	2019-09-24	2020-01-15	Ye, J.,Li, J.,Ye, F.,Zhang, Y.,Zhang, M.,Wang, C.	Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance.	Proc.Natl.Acad.Sci.USA	2020	117	1207	1215	
6L2P	31821989	Threonyl-tRNA synthetase from Salmonella enterica in the apo form	2019-10-05	2020-01-15	Guo, J.,Chen, B.,Yu, Y.,Cheng, B.,Cheng, Y.,Ju, Y.,Gu, Q.,Xu, J.,Zhou, H.	Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.	Eur.J.Med.Chem.	2019	187	111941	111941	
6J6V		Crystal structure of heat shock factor 4-DBD	2019-01-16	2020-01-22	Guo, L.,Xiao, Z.Y.,Wang, S.,Liu, W.	Structure of heat shock factor 4-DBD at 1.20 Angstroms resolution.	To Be Published	0	0	0	0	
6LDZ	31942069	Crystal structure of Rv0222 from Mycobacterium tuberculosis	2019-11-23	2020-01-22	Wang, L.,Wu, J.,Li, J.,Yang, H.,Tang, T.,Liang, H.,Zuo, M.,Wang, J.,Liu, H.,Liu, F.,Chen, J.,Liu, Z.,Wang, Y.,Peng, C.,Wu, X.,Zheng, R.,Huang, X.,Ran, Y.,Rao, Z.,Ge, B.	Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.	Nature	2020	577	682	688	
6NQ5		human (alpha met/beta hemichrome) hemoglobin with S-nitrosation at beta-Cys93	2019-01-19	2020-01-22	Yi, J.	human (alpha met/beta hemichrome) hemoglobin with S-nitrosation at beta-Cys93	To Be Published	0	0	0	0	
6J9O	30993000	Crystal structure of a free scFv molecule from a group 2 influenza A viruses HA binding antibody AF4H1K1	2019-01-23	2020-01-29	Xiao, H.,Guo, T.,Yang, M.,Qi, J.,Huang, C.,Hong, Y.,Gu, J.,Pang, X.,Liu, W.J.,Peng, R.,McCauley, J.,Bi, Y.,Li, S.,Feng, J.,Zhang, H.,Zhang, X.,Lu, X.,Yan, J.,Chen, L.,Shi, Y.,Chen, W.,Gao, G.F.	Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses.	Cell Discov	2019	5	21	21	
6KBB	32001508	Role of the DEF/Y motif of Swc5 in histone H2A.Z deposition	2019-06-24	2020-01-29	Huang, Y.,Sun, L.,Pierrakeas, L.,Dai, L.,Pan, L.,Luk, E.,Zhou, Z.	Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing.	Proc.Natl.Acad.Sci.USA	2020	117	3543	3550	
6KOL	31933173	Crystal structure of auracyanin from photosynthetic bacterium Roseiflexus castenholzii	2019-08-12	2020-01-29	Wang, C.,Xin, Y.,Min, Z.,Qi, J.,Zhang, C.,Xu, X.	Structural basis underlying the electron transfer features of a blue copper protein auracyanin from the photosynthetic bacterium Roseiflexus castenholzii.	Photosyn. Res.	2020	143	301	314	
6L3F	32008746	The structure of UTP:RNA uridylyltransferase 1 (URT1) in in Arabidopsis	2019-10-10	2020-01-29	Zhu, L.,Hu, Q.,Cheng, L.,Jiang, Y.,Lv, M.,Liu, Y.,Li, F.,Shi, Y.,Gong, Q.	Crystal structure of Arabidopsis terminal uridylyl transferase URT1.	Biochem.Biophys.Res.Commun.	2020	524	490	496	
6L8K	32008746	Structure of URT1 in complex with UTP	2019-11-06	2020-01-29	Zhu, L.,Hu, Q.,Cheng, L.,Jiang, Y.,Lv, M.,Liu, Y.,Li, F.,Shi, Y.,Gong, Q.	Crystal structure of Arabidopsis terminal uridylyl transferase URT1.	Biochem.Biophys.Res.Commun.	2020	524	490	496	
6L9S	31933173	Crystal structure of Na-dithionite reduced auracyanin from photosynthetic bacterium Roseiflexus castenholzii	2019-11-10	2020-01-29	Wang, C.,Xin, Y.,Min, Z.,Qi, J.,Zhang, C.,Xu, X.	Structural basis underlying the electron transfer features of a blue copper protein auracyanin from the photosynthetic bacterium Roseiflexus castenholzii.	Photosyn. Res.	2020	143	301	314	
6LR1	33097503	Hexachlorobenzene Monooxygenase (HcbA1) from Nocardioides sp. strain PD653	2020-01-15	2020-01-29	Guo, Y.,Li, D.F.,Ji, H.,Zheng, J.,Zhou, N.Y.	Hexachlorobenzene Monooxygenase Substrate Selectivity and Catalysis: Structural and Biochemical Insights.	Appl.Environ.Microbiol.	2020	87	0	0	
6JC7	32814814	Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with amino donor L-Ala	2019-01-28	2020-02-05	Xu, J.,Tang, X.,Zhu, Y.,Yu, Z.,Su, K.,Zhang, Y.,Dong, Y.,Zhu, W.,Zhang, C.,Wu, R.,Liu, J.	Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition.	Commun Biol	2020	3	455	455	
6JC8	32814814	Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with amino donor L-Glu	2019-01-28	2020-02-05	Xu, J.,Tang, X.,Zhu, Y.,Yu, Z.,Su, K.,Zhang, Y.,Dong, Y.,Zhu, W.,Zhang, C.,Wu, R.,Liu, J.	Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition.	Commun Biol	2020	3	455	455	
6JCA	32814814	Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in I222 space group	2019-01-28	2020-02-05	Xu, J.,Tang, X.,Zhu, Y.,Yu, Z.,Su, K.,Zhang, Y.,Dong, Y.,Zhu, W.,Zhang, C.,Wu, R.,Liu, J.	Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition.	Commun Biol	2020	3	455	455	
6JCB	32814814	Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in C2 space group	2019-01-28	2020-02-05	Xu, J.,Tang, X.,Zhu, Y.,Yu, Z.,Su, K.,Zhang, Y.,Dong, Y.,Zhu, W.,Zhang, C.,Wu, R.,Liu, J.	Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition.	Commun Biol	2020	3	455	455	
6KTC	32015133	Crystal structure of YBX1 CSD with m5C RNA	2019-08-27	2020-02-05	Zou, F.,Tu, R.,Duan, B.,Yang, Z.,Ping, Z.,Song, X.,Chen, S.,Price, A.,Li, H.,Scott, A.,Perera, A.,Li, S.,Xie, T.	DrosophilaYBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs.	Proc.Natl.Acad.Sci.USA	2020	117	3603	3609	
6KUG	32015133	Crystal structure of YBX1 CSD with RNA	2019-09-02	2020-02-05	Zou, F.,Tu, R.,Duan, B.,Yang, Z.,Ping, Z.,Song, X.,Chen, S.,Price, A.,Li, H.,Scott, A.,Perera, A.,Li, S.,Xie, T.	DrosophilaYBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs.	Proc.Natl.Acad.Sci.USA	2020	117	3603	3609	
6VFZ	32071674	Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with NADPH and AG-881 (Vorasidenib) Inhibitor.	2020-01-07	2020-02-05	Konteatis, Z.,Artin, E.,Nicolay, B.,Straley, K.,Padyana, A.K.,Jin, L.,Chen, Y.,Narayaraswamy, R.,Tong, S.,Wang, F.,Zhou, D.,Cui, D.,Cai, Z.,Luo, Z.,Fang, C.,Tang, H.,Lv, X.,Nagaraja, R.,Yang, H.,Su, S.M.,Sui, Z.,Dang, L.,Yen, K.,Popovici-Muller, J.,Codega, P.,Campos, C.,Mellinghoff, I.K.,Biller, S.A.	Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.	Acs Med.Chem.Lett.	2020	11	101	107	
6AKR	33234690	Crystal structure of the PDE4D catalytic domain in complex with osthole	2018-09-03	2020-02-12	Wang, S.,Xie, Y.,Huo, Y.W.,Li, Y.,Abel, P.W.,Jiang, H.,Zou, X.,Jiao, H.Z.,Kuang, X.,Wolff, D.W.,Huang, Y.G.,Casale, T.B.,Panettieri Jr., R.A.,Wei, T.,Cao, Z.,Tu, Y.	Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma.	Sci.Signal.	2020	13	0	0	
6JFP	32338906	Crystal structure of the beta-glucosidase Bgl15	2019-02-11	2020-02-12	Cao, L.,Chen, R.,Huang, X.,Li, S.,Zhang, S.,Yang, X.,Qin, Z.,Kong, W.,Xie, W.,Liu, Y.	Engineering of beta-Glucosidase Bgl15 with Simultaneously Enhanced Glucose Tolerance and Thermostability To Improve Its Performance in High-Solid Cellulose Hydrolysis.	J.Agric.Food Chem.	2020	68	5391	5401	
6K81	31908845	Crystal structure of human VASH1-SVBP complex	2019-06-11	2020-02-19	Liu, X.,Wang, H.,Zhu, J.,Xie, Y.,Liang, X.,Chen, Z.,Feng, Y.,Zhang, Y.	Structural insights into tubulin detyrosination by vasohibins-SVBP complex.	Cell Discov	2019	5	65	65	
6KV2	31981663	Crystal structure of trypsin inhibitor 1 from Senna obtusifolia	2019-09-03	2020-02-19	Zhou, J.,Li, C.,Chen, A.,Zhu, J.,Zou, M.,Liao, H.,Yu, Y.	Structural and functional relationship of Cassia obtusifolia trypsin inhibitor to understand its digestive resistance against Pieris rapae.	Int.J.Biol.Macromol.	2020	148	908	920	
6L5P	31986016	crystal structure of GgCGT in complex with UDP-Glu	2019-10-24	2020-02-19	Zhang, M.,Li, F.D.,Li, K.,Wang, Z.L.,Wang, Y.X.,He, J.B.,Su, H.F.,Zhang, Z.Y.,Chi, C.B.,Shi, X.M.,Yun, C.H.,Zhang, Z.Y.,Liu, Z.M.,Zhang, L.R.,Yang, D.H.,Ma, M.,Qiao, X.,Ye, M.	Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase fromGlycyrrhiza glabra.	J.Am.Chem.Soc.	2020	142	3506	3512	
6L5Q	31986016	crystal structure of GgCGT in complex with UDP-Gal	2019-10-24	2020-02-19	Zhang, M.,Li, F.D.,Li, K.,Wang, Z.L.,Wang, Y.X.,He, J.B.,Su, H.F.,Zhang, Z.Y.,Chi, C.B.,Shi, X.M.,Yun, C.H.,Zhang, Z.Y.,Liu, Z.M.,Zhang, L.R.,Yang, D.H.,Ma, M.,Qiao, X.,Ye, M.	Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase fromGlycyrrhiza glabra.	J.Am.Chem.Soc.	2020	142	3506	3512	
6L5R	31986016	crystal structure of GgCGT in complex with UDP-Glu	2019-10-24	2020-02-19	Zhang, M.,Li, F.D.,Li, K.,Wang, Z.L.,Wang, Y.X.,He, J.B.,Su, H.F.,Zhang, Z.Y.,Chi, C.B.,Shi, X.M.,Yun, C.H.,Zhang, Z.Y.,Liu, Z.M.,Zhang, L.R.,Yang, D.H.,Ma, M.,Qiao, X.,Ye, M.	Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase fromGlycyrrhiza glabra.	J.Am.Chem.Soc.	2020	142	3506	3512	
6L5S	31986016	crystal structure of GgCGT in complex with UDP-Glu	2019-10-24	2020-02-19	Zhang, M.,Li, F.D.,Li, K.,Wang, Z.L.,Wang, Y.X.,He, J.B.,Su, H.F.,Zhang, Z.Y.,Chi, C.B.,Shi, X.M.,Yun, C.H.,Zhang, Z.Y.,Liu, Z.M.,Zhang, L.R.,Yang, D.H.,Ma, M.,Qiao, X.,Ye, M.	Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase fromGlycyrrhiza glabra.	J.Am.Chem.Soc.	2020	142	3506	3512	
6LGW	32004500	Structure of Rabies virus glycoprotein in complex with neutralizing antibody 523-11 at acidic pH	2019-12-06	2020-02-19	Yang, F.,Lin, S.,Ye, F.,Yang, J.,Qi, J.,Chen, Z.,Lin, X.,Wang, J.,Yue, D.,Cheng, Y.,Chen, Z.,Chen, H.,You, Y.,Zhang, Z.,Yang, Y.,Yang, M.,Sun, H.,Li, Y.,Cao, Y.,Yang, S.,Wei, Y.,Gao, G.F.,Lu, G.	Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody.	Cell Host Microbe	2020	27	441	0	
6LND	31913359	Crystal structure of transposition protein TniQ	2019-12-28	2020-02-19	Wang, B.,Xu, W.,Yang, H.	Structural basis of a Tn7-like transposase recruitment and DNA loading to CRISPR-Cas surveillance complex.	Cell Res.	2020	30	185	187	
6JIT		Complex structure of an imine reductase at 2.05 Angstrom resolution	2019-02-23	2020-02-26	Li, H.,Wu, L.,Zheng, G.W.,Zhou, J.H.	Complex structure of an imine reductase at 2.05 Angstrom resolution	To Be Published	0	0	0	0	
6JIZ		Apo structure of an imine reductase at 1.76 Angstrom resolution	2019-02-24	2020-02-26	Li, H.,Wu, L.,Zheng, G.W.,Zhou, J.H.	Apo structure of an imine reductase at 1.76 Angstrom resolution	To Be Published	0	0	0	0	
6JJE		Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex (BrU)	2019-02-25	2020-02-26	Zhang, Y.S.,Parkinson, G.N.,Wagner, A.,Wei, D.G.	Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex (BrU)	To Be Published	0	0	0	0	
6JJI	32453431	Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4 (1:1)	2019-02-25	2020-02-26	Zhang, Y.,El Omari, K.,Duman, R.,Liu, S.,Haider, S.,Wagner, A.,Parkinson, G.N.,Wei, D.	Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.	Nucleic Acids Res.	2020	48	9886	9898	
6LAE	31962067	Crystal structure of the DNA-binding domain of human XPA in complex with DNA	2019-11-12	2020-02-26	Lian, F.M.,Yang, X.,Jiang, Y.L.,Yang, F.,Li, C.,Yang, W.,Qian, C.	New structural insights into the recognition of undamaged splayed-arm DNA with a single pair of non-complementary nucleotides by human nucleotide excision repair protein XPA.	Int.J.Biol.Macromol.	2020	148	466	474	
6LJB	32075933	Crystal Structure of ASFV pS273R protease	2019-12-13	2020-02-26	Li, G.,Liu, X.,Yang, M.,Zhang, G.,Wang, Z.,Guo, K.,Gao, Y.,Jiao, P.,Sun, J.,Chen, C.,Wang, H.,Deng, W.,Xiao, H.,Li, S.,Wu, H.,Wang, Y.,Cao, L.,Jia, Z.,Shang, L.,Yang, C.,Guo, Y.,Rao, Z.	Crystal Structure of African Swine Fever Virus pS273R Protease and Implications for Inhibitor Design.	J.Virol.	2020	94	0	0	
6LW3	32085896	Crystal structure of RuvC from Pseudomonas aeruginosa	2020-02-07	2020-02-26	Hu, Y.,He, Y.,Lin, Z.	Biochemical and structural characterization of the Holliday junction resolvase RuvC from Pseudomonas aeruginosa.	Biochem.Biophys.Res.Commun.	2020	525	265	271	
6JL7	32453802	crystal structure of TBC1D23 N terminal domain	2019-03-04	2020-03-04	Liu, D.,Yang, F.,Liu, Z.,Wang, J.,Huang, W.,Meng, W.,Billadeau, D.D.,Sun, Q.,Mo, X.,Jia, D.	Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain.	Plos Biol.	2020	18	0	0	
6JOY	33988022	The X-ray Crystallographic Structure of Branching Enzyme from Rhodothermus obamensis STB05	2019-03-25	2020-03-04	Jiang, H.,Xie, X.,Ban, X.,Gu, Z.,Cheng, L.,Hong, Y.,Li, C.,Li, Z.	Flexible Loop in Carbohydrate-Binding Module 48 Allosterically Modulates Substrate Binding of the 1,4-alpha-Glucan Branching Enzyme.	J.Agric.Food Chem.	2021	69	5755	5763	
6JYJ	32009146	Crystal structure of FAM46B (TENT5B)	2019-04-26	2020-03-04	Hu, J.L.,Liang, H.,Zhang, H.,Yang, M.Z.,Sun, W.,Zhang, P.,Luo, L.,Feng, J.X.,Bai, H.,Liu, F.,Zhang, T.,Yang, J.Y.,Gao, Q.,Long, Y.,Ma, X.Y.,Chen, Y.,Zhong, Q.,Yu, B.,Liao, S.,Wang, Y.,Zhao, Y.,Zeng, M.S.,Cao, N.,Wang, J.,Chen, W.,Yang, H.T.,Gao, S.	FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.	Nucleic Acids Res.	2020	48	2733	2748	
6L6X	32074393	The structure of ScoE with substrate	2019-10-29	2020-03-04	Chen, T.Y.,Chen, J.,Tang, Y.,Zhou, J.,Guo, Y.,Chang, W.C.	Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases.	Angew.Chem.Int.Ed.Engl.	2020	59	7367	7371	
6L86	32074393	The structure of SfaA	2019-11-05	2020-03-04	Chen, T.Y.,Chen, J.,Tang, Y.,Zhou, J.,Guo, Y.,Chang, W.C.	Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases.	Angew.Chem.Int.Ed.Engl.	2020	59	7367	7371	
6JLH	32156735	Structure of SCGN in complex with a Snap25 peptide	2019-03-05	2020-03-11	Qin, J.,Liu, Q.,Liu, Z.,Pan, Y.Z.,Sifuentes-Dominguez, L.,Stepien, K.P.,Wang, Y.,Tu, Y.,Tan, S.,Wang, Y.,Sun, Q.,Mo, X.,Rizo, J.,Burstein, E.,Jia, D.	Structural and mechanistic insights into secretagogin-mediated exocytosis.	Proc.Natl.Acad.Sci.USA	2020	117	6559	6570	
6JMG		Crystal structure of xRbj	2019-03-09	2020-03-11	Gao, Z.R.,Qi, J.X.	Crystal structure of Rbj	To Be Published	0	0	0	0	
6KGH	32086254	Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis (apo-form)	2019-07-11	2020-03-11	Lu, Z.,Wang, H.,Zhang, A.,Liu, X.,Zhou, W.,Yang, C.,Guddat, L.,Yang, H.,Schofield, C.J.,Rao, Z.	Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.	Mol.Pharmacol.	2020	97	287	294	
6KGS	32086254	Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with meropenem	2019-07-12	2020-03-11	Lu, Z.,Wang, H.,Zhang, A.,Liu, X.,Zhou, W.,Yang, C.,Guddat, L.,Yang, H.,Schofield, C.J.,Rao, Z.	Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.	Mol.Pharmacol.	2020	97	287	294	
6KGT	32086254	Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with faropenem	2019-07-12	2020-03-11	Lu, Z.,Wang, H.,Zhang, A.,Liu, X.,Zhou, W.,Yang, C.,Guddat, L.,Yang, H.,Schofield, C.J.,Rao, Z.	Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.	Mol.Pharmacol.	2020	97	287	294	
6KGU	32086254	Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with aztreonam	2019-07-12	2020-03-11	Lu, Z.,Wang, H.,Zhang, A.,Liu, X.,Zhou, W.,Yang, C.,Guddat, L.,Yang, H.,Schofield, C.J.,Rao, Z.	Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.	Mol.Pharmacol.	2020	97	287	294	
6KGV	32086254	Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with amoxicillin	2019-07-12	2020-03-11	Lu, Z.,Wang, H.,Zhang, A.,Liu, X.,Zhou, W.,Yang, C.,Guddat, L.,Yang, H.,Schofield, C.J.,Rao, Z.	Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.	Mol.Pharmacol.	2020	97	287	294	
6KGW	32086254	Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with ampicillin	2019-07-12	2020-03-11	Lu, Z.,Wang, H.,Zhang, A.,Liu, X.,Zhou, W.,Yang, C.,Guddat, L.,Yang, H.,Schofield, C.J.,Rao, Z.	Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.	Mol.Pharmacol.	2020	97	287	294	
6KON	32127479	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 5 nt	2019-08-12	2020-03-11	Li, L.,Molodtsov, V.,Lin, W.,Ebright, R.H.,Zhang, Y.	RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.	Proc.Natl.Acad.Sci.USA	2020	117	5801	5809	
6KOO	32127479	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 7 nt	2019-08-12	2020-03-11	Li, L.,Molodtsov, V.,Lin, W.,Ebright, R.H.,Zhang, Y.	RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.	Proc.Natl.Acad.Sci.USA	2020	117	5801	5809	
6KOQ	32127479	Mycobacterium tuberculosis initial transcription complex comprising sigma H and 5'-OH RNA of 10 nt	2019-08-12	2020-03-11	Li, L.,Molodtsov, V.,Lin, W.,Ebright, R.H.,Zhang, Y.	RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.	Proc.Natl.Acad.Sci.USA	2020	117	5801	5809	
6JMD	32496056	Crystal structure of human DHODH in complex with inhibitor 1223	2019-03-08	2020-03-18	Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y.	Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.	J.Med.Chem.	2020	63	7633	7652	
6JME	32496056	Crystal structure of human DHODH in complex with inhibitor 0946	2019-03-08	2020-03-18	Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y.	Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.	J.Med.Chem.	2020	63	7633	7652	
6K2U	32330457	Crystal structure of Thr66 ADP-ribosylated ubiquitin	2019-05-15	2020-03-18	Yan, F.,Huang, C.,Wang, X.,Tan, J.,Cheng, S.,Wan, M.,Wang, Z.,Wang, S.,Luo, S.,Li, A.,Guo, X.,Feng, M.,Liu, X.,Zhu, Y.,Zhou, Y.	Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination.	Mol.Cell	2020	78	641	0	
6JIV	32251370	SspE crystal structure	2019-02-23	2020-03-25	Xiong, X.,Wu, G.,Wei, Y.,Liu, L.,Zhang, Y.,Su, R.,Jiang, X.,Li, M.,Gao, H.,Tian, X.,Zhang, Y.,Hu, L.,Chen, S.,Tang, Y.,Jiang, S.,Huang, R.,Li, Z.,Wang, Y.,Deng, Z.,Wang, J.,Dedon, P.C.,Chen, S.,Wang, L.	SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.	Nat Microbiol	2020	5	917	928	
6JOI		Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization	2019-03-22	2020-03-25	Liang, L.,Yan, X.E.	Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization	To Be Published	0	0	0	0	
6JOJ		Crystal structure of PDGFRA T674I in complex with crenolanib by soaking	2019-03-22	2020-03-25	Liang, L.,Yan, X.E.	Crystal structure of PDGFRA in complex with crenolanib by soaking	To Be Published	0	0	0	0	
6JOK		Crystal structure of PDGFRA in complex with sunitinib by soaking	2019-03-22	2020-03-25	Liang, L.,Yan, X.E.	Crystal structure of PDGFRA in complex with sunitinib by soaking	To Be Published	0	0	0	0	
6JOL		Crystal structure of PDGFRA in complex with imatinib by co-crystallization	2019-03-22	2020-03-25	Liang, L.,Yan, X.E.	Crystal structure of PDGFRA in complex with imatinib by co-crystallization	To Be Published	0	0	0	0	
6JOM	32373550	Crystal structure of lipoate protein ligase from Mycoplasma hyopneumoniae	2019-03-22	2020-03-25	Zhu, K.,Chen, H.,Jin, J.,Wang, N.,Ma, G.,Huang, J.,Feng, Y.,Xin, J.,Zhang, H.,Liu, H.	Functional Identification and Structural Analysis of a New Lipoate Protein Ligase inMycoplasma hyopneumoniae.	Front Cell Infect Microbiol	2020	10	156	156	
6KU7	32103448	structure of HRV-C 3C protein	2019-08-31	2020-03-25	Yuan, S.,Fan, K.,Chen, Z.,Sun, Y.,Hou, H.,Zhu, L.	Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design.	Virol Sin	2020	35	445	454	
6KU8	32103448	structure of HRV-C 3C protein with rupintrivir	2019-08-31	2020-03-25	Yuan, S.,Fan, K.,Chen, Z.,Sun, Y.,Hou, H.,Zhu, L.	Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design.	Virol Sin	2020	35	445	454	
6LPF	32232361	The crystal structure of human cytoplasmic LRS	2020-01-10	2020-03-25	Liu, R.J.,Long, T.,Li, H.,Zhao, J.,Li, J.,Wang, M.,Palencia, A.,Lin, J.,Cusack, S.,Wang, E.D.	Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.	Nucleic Acids Res.	2020	48	4946	4959	
6LR6	32232361	The crystal structure of human cytoplasmic LRS	2020-01-15	2020-03-25	Liu, R.J.,Long, T.,Li, H.,Zhao, J.,Li, J.,Wang, M.,Palencia, A.,Lin, J.,Cusack, S.,Wang, E.D.	Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.	Nucleic Acids Res.	2020	48	4946	4959	
6JBY		Crystal structure of endo-deglycosylated hydroxynitrile lyase isozyme 5 of Prunus communis	2019-01-27	2020-04-01	Zheng, Y.C.,Li, F.L.,Lin, Z.M.,Lin, G.Q.,Hong, R.,Yu, H.L.,Xu, J.H.	Structure-Guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes.	Acs Catalysis	2020	0	0	0	
6JQB	31751711	The structure of maltooligosaccharide-forming amylase from Pseudomonas saccharophila STB07 with pseudo-maltoheptaose	2019-03-30	2020-04-01	Zhang, Z.,Jin, T.,Xie, X.,Ban, X.,Li, C.,Hong, Y.,Cheng, L.,Gu, Z.,Li, Z.	Structure of maltotetraose-forming amylase from Pseudomonas saccharophila STB07 provides insights into its product specificity.	Int.J.Biol.Macromol.	2020	154	1303	1313	
6JZQ	32251275	The crystal structure of acyl-acyl carrier protein (acyl-ACP) reductase (AAR)	2019-05-03	2020-04-01	Gao, Y.,Zhang, H.,Fan, M.,Jia, C.,Shi, L.,Pan, X.,Cao, P.,Zhao, X.,Chang, W.,Li, M.	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase.	Nat Commun	2020	11	1525	1525	
6JZU	32251275	The crystal structure of acyl-acyl carrier protein (acyl-ACP) reductase (AAR) in complex with aldehyde deformylating oxygenase (ADO)	2019-05-03	2020-04-01	Gao, Y.,Zhang, H.,Fan, M.,Jia, C.,Shi, L.,Pan, X.,Cao, P.,Zhao, X.,Chang, W.,Li, M.	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase.	Nat Commun	2020	11	1525	1525	
6JZY	32251275	Crystal structure of AAR with NADPH and stearyl in complex with ADO binding a long chain carbohydrate	2019-05-04	2020-04-01	Gao, Y.,Zhang, H.,Fan, M.,Jia, C.,Shi, L.,Pan, X.,Cao, P.,Zhao, X.,Chang, W.,Li, M.	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase.	Nat Commun	2020	11	1525	1525	
6JZZ	32251275	The crystal structure of AAR-C294S in complex with ADO.	2019-05-04	2020-04-01	Gao, Y.,Zhang, H.,Fan, M.,Jia, C.,Shi, L.,Pan, X.,Cao, P.,Zhao, X.,Chang, W.,Li, M.	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase.	Nat Commun	2020	11	1525	1525	
6K3B	32286321	Crystal structure of Lpg2147-Lpg2149 complex	2019-05-17	2020-04-01	Mu, Y.,Wang, Y.,Huang, Y.,Li, D.,Han, Y.,Chang, M.,Fu, J.,Xie, Y.,Ren, J.,Wang, H.,Zhang, Y.,Luo, Z.Q.,Feng, Y.	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.	Nat Commun	2020	11	1774	1774	
6KFP	32286321	Crystal structure of MavC ternary complex	2019-07-08	2020-04-01	Mu, Y.,Wang, Y.,Huang, Y.,Li, D.,Han, Y.,Chang, M.,Fu, J.,Xie, Y.,Ren, J.,Wang, H.,Zhang, Y.,Luo, Z.Q.,Feng, Y.	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.	Nat Commun	2020	11	1774	1774	
6KG6	32286321	Crystal structure of MavC/UBE2N-Ub complex	2019-07-10	2020-04-01	Mu, Y.,Wang, Y.,Huang, Y.,Li, D.,Han, Y.,Chang, M.,Fu, J.,Xie, Y.,Ren, J.,Wang, H.,Zhang, Y.,Luo, Z.Q.,Feng, Y.	Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.	Nat Commun	2020	11	1774	1774	
6L8W		Crystal structure of ugt transferase mutant2	2019-11-07	2020-04-01	Li, J.,Yang, J.G.,Mu, S.,Shang, N.,Liu, C.,Zhu, Y.,Cai, Y.,Liu, P.,Lin, J.,Liu, W.D.,Sun, Y.X.,Ma, Y.	Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1	Acs Catalysis	2020	0	0	0	
6L8Z		Crystal structure of ugt transferase mutant in complex with UPG	2019-11-07	2020-04-01	Li, J.,Yang, J.G.,Mu, S.,Shang, N.,Liu, C.,Zhu, Y.,Cai, Y.,Liu, P.,Lin, J.,Liu, W.D.,Sun, Y.X.,Ma, Y.	Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1	Acs Catalysis	2020	0	0	0	
6L90		Crystal structure of ugt transferase enzyme	2019-11-07	2020-04-01	Li, J.,Yang, J.G.,Mu, S.,Shang, N.,Liu, C.,Zhu, Y.,Cai, Y.,Liu, P.,Lin, J.,Liu, W.D.,Sun, Y.X.,Ma, Y.	Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1	Acs Catalysis	2020	0	0	0	
6JQK		Structure of C34M/N36	2019-03-31	2020-04-08	Yu, D.W.,Qin, B.	Structure of C34M/N36	To Be Published	0	0	0	0	
6KA6	32195573	Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1	2019-06-21	2020-04-08	Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P.	Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.	Acs Chem.Biol.	2020	15	1016	1025	
6KAB	32195573	Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2	2019-06-21	2020-04-08	Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P.	Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.	Acs Chem.Biol.	2020	15	1016	1025	
6KBF	32195573	Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3	2019-06-24	2020-04-08	Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P.	Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.	Acs Chem.Biol.	2020	15	1016	1025	
6KCN	32195573	Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4	2019-06-28	2020-04-08	Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P.	Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.	Acs Chem.Biol.	2020	15	1016	1025	
6KCT	32195573	Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 5	2019-06-29	2020-04-08	Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P.	Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.	Acs Chem.Biol.	2020	15	1016	1025	
6KVN	32184398	Crystal structure of chloroplast resolvase	2019-09-05	2020-04-08	Yan, J.,Hong, S.,Guan, Z.,He, W.,Zhang, D.,Yin, P.	Structural insights into sequence-dependent Holliday junction resolution by the chloroplast resolvase MOC1.	Nat Commun	2020	11	1417	1417	
6L5T	32216114	The crystal structure of SADS-CoV Papain Like protease	2019-10-24	2020-04-08	Wang, L.,Hu, W.,Fan, C.	Structural and biochemical characterization of SADS-CoV papain-like protease 2.	Protein Sci.	2020	29	1228	1241	
6L8X		Crystal structure of Siraitia grosvenorii ugt transferase mutant2	2019-11-07	2020-04-08	Li, J.,Yang, J.G.,Mu, S.,Shang, N.,Liu, C.,Zhu, Y.,Cai, Y.,Liu, P.,Lin, J.,Liu, W.D.,Sun, Y.X.,Ma, Y.	Efficient O-Glycosylation of Triterpenes Enabled by Protein Engineering of Plant Glycosyltransferase UGT74AC1	Acs Catalysis	2020	10	3629	3639	
6LCT	32184398	Crystal structure of catalytic inactive chloroplast resolvase NtMOC1 in complex with Holliday junction	2019-11-19	2020-04-08	Yan, J.,Hong, S.,Guan, Z.,He, W.,Zhang, D.,Yin, P.	Structural insights into sequence-dependent Holliday junction resolution by the chloroplast resolvase MOC1.	Nat Commun	2020	11	1417	1417	
6LNM	32348748	Crystal structure of CASK-CaMK in complex with Mint1-CID	2019-12-31	2020-04-08	Wu, X.,Cai, Q.,Chen, Y.,Zhu, S.,Mi, J.,Wang, J.,Zhang, M.	Structural Basis for the High-Affinity Interaction between CASK and Mint1.	Structure	2020	28	664	0	
6LP5	31983429	Structure of Sinonovacula constricta ferritin	2020-01-08	2020-04-08	Su, C.,Ming, T.,Wu, Y.,Jiang, Q.,Huan, H.,Lu, C.,Zhou, J.,Li, Y.,Song, H.,Su, X.	Crystallographic characterization of ferritin from Sinonovacula constricta.	Biochem.Biophys.Res.Commun.	2020	524	217	223	
6JRJ	31298540	The structure of co-crystals of 8r-B-EGFR T790M/C797S complex	2019-04-04	2020-04-15	Shen, J.,Zhang, T.,Zhu, S.J.,Sun, M.,Tong, L.,Lai, M.,Zhang, R.,Xu, W.,Wu, R.,Ding, J.,Yun, C.H.,Xie, H.,Lu, X.,Ding, K.	Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).	J.Med.Chem.	2019	62	7302	7308	
6JRK	31298540	The structure of co-crystals of 8r-B-EGFR WT complex	2019-04-04	2020-04-15	Shen, J.,Zhang, T.,Zhu, S.J.,Sun, M.,Tong, L.,Lai, M.,Zhang, R.,Xu, W.,Wu, R.,Ding, J.,Yun, C.H.,Xie, H.,Lu, X.,Ding, K.	Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).	J.Med.Chem.	2019	62	7302	7308	
6JRX	31244114	EGFR T790M/C797S in complex with compound 6i	2019-04-06	2020-04-15	Yang, J.,Shibu, M.A.,Kong, L.,Luo, J.,BadrealamKhan, F.,Huang, Y.,Tu, Z.C.,Yun, C.H.,Huang, C.Y.,Ding, K.,Lu, X.	Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.	J.Med.Chem.	2020	63	2114	2130	
6JUG	33128114	Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose	2019-04-13	2020-04-15	Li, Z.,Zhang, X.,Li, C.,Kovalevsky, A.,Wan, Q.	Studying the Role of a Single Mutation of a Family 11 Glycoside Hydrolase Using High-Resolution X-ray Crystallography.	Protein J.	2020	39	671	680	
6LZL		Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine	2020-02-19	2020-04-15	Liu, Z.H.,Wu, D.,Lu, W.Q.,Huang, J.	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine	To Be Published	0	0	0	0	
7BQW		Crystal structure of Methionine gamma-lyase from Fusobacterium nucleatum	2020-03-25	2020-04-15	Lan, J.,Liu, W.,Chen, Y.,Xu, Y.	Crystal structure of Methionine gamma-lyase from Fusobacterium nucleatum	To Be Published	0	0	0	0	
6JTG	32379273	Structural insights into G domain dimerization and pathogenic mutations of OPA1	2019-04-11	2020-04-22	Yu, C.,Zhao, J.,Yan, L.,Qi, Y.,Guo, X.,Lou, Z.,Hu, J.,Rao, Z.	Structural insights into G domain dimerization and pathogenic mutation of OPA1.	J.Cell Biol.	2020	219	0	0	
6JUU	31244114	Crystal structure of ZAK in complex with compound 6r	2019-04-15	2020-04-22	Yang, J.,Shibu, M.A.,Kong, L.,Luo, J.,BadrealamKhan, F.,Huang, Y.,Tu, Z.C.,Yun, C.H.,Huang, C.Y.,Ding, K.,Lu, X.	Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.	J.Med.Chem.	2020	63	2114	2130	
6JW5	31863750	RVD Q* recognizes 5hmC through water-mediated H bonds	2019-04-18	2020-04-22	Liu, L.,Zhang, Y.,Liu, M.,Wei, W.,Yi, C.,Peng, J.	Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors.	J.Mol.Biol.	2020	432	1035	1047	
6JWB	33128114	Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose	2019-04-19	2020-04-22	Li, Z.,Zhang, X.,Li, C.,Kovalevsky, A.,Wan, Q.	Studying the Role of a Single Mutation of a Family 11 Glycoside Hydrolase Using High-Resolution X-ray Crystallography.	Protein J.	2020	39	671	680	
6JX4	32672461	Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by soaking	2019-04-22	2020-04-22	Yan, X.E.,Ayaz, P.,Zhu, S.J.,Zhao, P.,Liang, L.,Zhang, C.H.,Wu, Y.C.,Li, J.L.,Choi, H.G.,Huang, X.,Shan, Y.,Shaw, D.E.,Yun, C.H.	Structural Basis of AZD9291 Selectivity for EGFR T790M.	J.Med.Chem.	2020	63	8502	8511	
6LXH	32250096	Staphylococcus aureus surface protein-sdrc	2020-02-11	2020-04-22	Pi, Y.,Chen, W.,Ji, Q.	Structural Basis ofStaphylococcus aureusSurface Protein SdrC.	Biochemistry	2020	59	1465	1469	
6LXS	32250096	CWA protein-SdrC	2020-02-11	2020-04-22	Pi, Y.,Chen, W.,Ji, Q.	Structural Basis ofStaphylococcus aureusSurface Protein SdrC.	Biochemistry	2020	59	1465	1469	
6PC4	31860298	Tubulin-RB3_SLD-TTL in complex with compound ABI-274	2019-06-15	2020-04-22	Chen, H.,Deng, S.,Wang, Y.,Albadari, N.,Kumar, G.,Ma, D.,Li, W.,White, S.W.,Miller, D.D.,Li, W.	Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.	J.Med.Chem.	2020	63	827	846	
7BQY	32272481	THE CRYSTAL STRUCTURE OF COVID-19 MAIN PROTEASE IN COMPLEX WITH AN INHIBITOR N3 at 1.7 angstrom	2020-03-26	2020-04-22	Jin, Z.,Du, X.,Xu, Y.,Deng, Y.,Liu, M.,Zhao, Y.,Zhang, B.,Li, X.,Zhang, L.,Peng, C.,Duan, Y.,Yu, J.,Wang, L.,Yang, K.,Liu, F.,Jiang, R.,Yang, X.,You, T.,Liu, X.,Yang, X.,Bai, F.,Liu, H.,Liu, X.,Guddat, L.W.,Xu, W.,Xiao, G.,Qin, C.,Shi, Z.,Jiang, H.,Rao, Z.,Yang, H.	Structure of Mprofrom SARS-CoV-2 and discovery of its inhibitors.	Nature	2020	582	289	293	
6JXL		Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose	2019-04-23	2020-04-29	Wan, Q.	Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose	To Be Published	0	0	0	0	
6JYM	32673951	Crystal structure of Prolyl Endopeptidase from Haliotis discus hannai	2019-04-26	2020-04-29	Li, W.Y.,Li, Y.,Chen, Y.L.,Hu, J.J.,Mengist, H.M.,Liu, G.M.,Jin, T.,Cao, M.J.	Characterization and crystal structure of prolyl endopeptidase from abalone (Haliotis discus hannai).	FOOD CHEM	2020	333	127452	127452	
6KLR	32483132	Crystal structure of human WIPI3 in complex with the WIR-peptide from ATG2A	2019-07-30	2020-04-29	Ren, J.,Liang, R.,Wang, W.,Zhang, D.,Yu, L.,Feng, W.	Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy.	Nat Commun	2020	11	2702	2702	
6LSE	32451382	Crystal structure of the enterovirus 71 polymerase elongation complex (C3S6A/C3S6B form)	2020-01-17	2020-04-29	Wang, M.,Li, R.,Shu, B.,Jing, X.,Ye, H.Q.,Gong, P.	Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures.	Nat Commun	2020	11	2605	2605	
6LY4	32243054	The crystal structure of the BM3 mutant LG-23 in complex with testosterone	2020-02-13	2020-04-29	Li, A.,Acevedo-Rocha, C.G.,D'Amore, L.,Chen, J.,Peng, Y.,Garcia-Borras, M.,Gao, C.,Zhu, J.,Rickerby, H.,Osuna, S.,Zhou, J.,Reetz, M.T.	Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants.	Angew.Chem.Int.Ed.Engl.	2020	59	12499	12505	
6JPE	33030342	Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1	2019-03-26	2020-05-06	Rezende Miranda, R.,Fu, Y.,Chen, X.,Perino, J.,Cao, P.,Carpten, J.,Chen, Y.,Zhang, C.	Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma.	J.Med.Chem.	2020	63	11484	11497	
6JZP		Crystal Structures of Endo-beta-1,4-xylanase II Complexed with Xylotriose	2019-05-03	2020-05-06	Wan, Q.,Qiu, Z.	X-ray crystallographic studies of family 11 xylanase Michaelis and product complexes: implications for the catalytic mechanism	To Be Published	0	0	0	0	
6LNP	32875085	Crystal structure of citrate Biosensor	2019-12-31	2020-05-06	Zhao, Y.,Shen, Y.,Wen, Y.,Campbell, R.E.	High-Performance Intensiometric Direct- and Inverse-Response Genetically Encoded Biosensors for Citrate.	Acs Cent.Sci.	2020	6	1441	1450	
6J7O	32382148	Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant E146Q from Mycobacterium tuberculosis	2019-01-18	2020-05-13	Yu, X.,Gao, X.,Zhu, K.,Yin, H.,Mao, X.,Wojdyla, J.A.,Qin, B.,Huang, H.,Wang, M.,Sun, Y.C.,Cui, S.	Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.	Commun Biol	2020	3	216	216	
6J7Q	32382148	Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant S78A from Mycobacterium tuberculosis	2019-01-18	2020-05-13	Yu, X.,Gao, X.,Zhu, K.,Yin, H.,Mao, X.,Wojdyla, J.A.,Qin, B.,Huang, H.,Wang, M.,Sun, Y.C.,Cui, S.	Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.	Commun Biol	2020	3	216	216	
6J7S	32382148	Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) wild type protein from Mycobacterium tuberculosis	2019-01-18	2020-05-13	Yu, X.,Gao, X.,Zhu, K.,Yin, H.,Mao, X.,Wojdyla, J.A.,Qin, B.,Huang, H.,Wang, M.,Sun, Y.C.,Cui, S.	Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.	Commun Biol	2020	3	216	216	
6J7T	32382148	Crystal structure of toxin TglT (unusual type guanylyltransferase-like toxin, Rv1045) mutant D82A from Mycobacterium tuberculosis	2019-01-18	2020-05-13	Yu, X.,Gao, X.,Zhu, K.,Yin, H.,Mao, X.,Wojdyla, J.A.,Qin, B.,Huang, H.,Wang, M.,Sun, Y.C.,Cui, S.	Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.	Commun Biol	2020	3	216	216	
6JUJ	32815230	Crystal structure of Formate dehydrogenase mutant V198I/C256I/P260S/E261P/S381N/S383F from Pseudomonas sp. 101in complex with non-natural cofactor Nicotinamide Cytosine Dinucleotide	2019-04-14	2020-05-13	Guo, X.,Wang, X.,Liu, Y.,Li, Q.,Wang, J.,Liu, W.,Zhao, Z.K.	Structure-Guided Design of Formate Dehydrogenase for Regeneration of a Non-Natural Redox Cofactor.	Chemistry	2020	26	16611	16615	
6JUK	32815230	Crystal structure of Formate dehydrogenase mutant C256I/E261P/S381I from Pseudomonas sp. 101 in complex with non-natural cofactor Nicotinamide Cytosine Dinucleotide	2019-04-14	2020-05-13	Guo, X.,Wang, X.,Liu, Y.,Li, Q.,Wang, J.,Liu, W.,Zhao, Z.K.	Structure-Guided Design of Formate Dehydrogenase for Regeneration of a Non-Natural Redox Cofactor.	Chemistry	2020	26	16611	16615	
6JWG	32815230	Crystal structure of Formate dehydrogenase mutant C256I/E261P/S381I from Pseudomonas sp. 101	2019-04-20	2020-05-13	Guo, X.,Wang, X.,Liu, Y.,Li, Q.,Wang, J.,Liu, W.,Zhao, Z.K.	Structure-Guided Design of Formate Dehydrogenase for Regeneration of a Non-Natural Redox Cofactor.	Chemistry	2020	26	16611	16615	
6JX1	32815230	Crystal structure of Formate dehydrogenase mutant V198I/C256I/P260S/E261P/S381N/S383F from Pseudomonas sp. 101	2019-04-21	2020-05-13	Guo, X.,Wang, X.,Liu, Y.,Li, Q.,Wang, J.,Liu, W.,Zhao, Z.K.	Structure-Guided Design of Formate Dehydrogenase for Regeneration of a Non-Natural Redox Cofactor.	Chemistry	2020	26	16611	16615	
6K0O	34193250	The crystal structure of human CD163-like homolog SRCR8	2019-05-07	2020-05-13	Ma, H.,Li, R.,Jiang, L.,Qiao, S.,Chen, X.X.,Wang, A.,Zhang, G.	Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro.	Vet Res	2021	52	97	97	
6K1L	33497694	E53A mutant of a putative cystathionine gamma-lyase	2019-05-10	2020-05-13	Wang, Y.,Chen, H.,Huang, Z.,Yang, M.,Yu, H.,Peng, M.,Yang, Z.,Chen, S.	Structural characterization of cystathionine gamma-lyase smCSE enables aqueous metal quantum dot biosynthesis.	Int.J.Biol.Macromol.	2021	174	42	51	
6K1M	33497694	Engineered form of a putative cystathionine gamma-lyase	2019-05-10	2020-05-13	Wang, Y.,Chen, H.,Huang, Z.,Yang, M.,Yu, H.,Peng, M.,Yang, Z.,Chen, S.	Structural characterization of cystathionine gamma-lyase smCSE enables aqueous metal quantum dot biosynthesis.	Int.J.Biol.Macromol.	2021	174	42	51	
6K20		Structure of Apo YdiU	2019-05-13	2020-05-13	Li, B.	Structure of Apo-YdiU	To Be Published	0	0	0	0	
6KEV	32102842	Reduced phosphoribulokinase from Synechococcus elongatus PCC 7942 complexed with adenosine diphosphate and glucose 6-phosphate	2019-07-05	2020-05-13	Yu, A.,Xie, Y.,Pan, X.,Zhang, H.,Cao, P.,Su, X.,Chang, W.,Li, M.	Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle.	Plant Cell	2020	32	1556	1573	
6KKM	32451445	Crystal structure of RbcL-Raf1 complex from Anabaena sp. PCC 7120	2019-07-26	2020-05-13	Xia, L.Y.,Jiang, Y.L.,Kong, W.W.,Sun, H.,Li, W.F.,Chen, Y.,Zhou, C.Z.	Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1.	Nat.Plants	2020	6	708	717	
6KKN	32451445	Crystal structure of RuBisCO accumulation factor Raf1 from Anabaena sp. PCC 7120	2019-07-26	2020-05-13	Xia, L.Y.,Jiang, Y.L.,Kong, W.W.,Sun, H.,Li, W.F.,Chen, Y.,Zhou, C.Z.	Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1.	Nat.Plants	2020	6	708	717	
6L2W	32337767	Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1	2019-10-07	2020-05-13	Wang, Y.,Jin, H.,Yang, F.,Jiang, Y.L.,Zhao, Y.Y.,Chen, Z.P.,Li, W.F.,Chen, Y.,Zhou, C.Z.,Li, Q.	Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1.	Proteins	2020	88	1226	1232	
6LMH	32358196	Structure of an ASFV-derived histone-like protein pA104R	2019-12-25	2020-05-13	Liu, R.,Sun, Y.,Chai, Y.,Li, S.,Li, S.,Wang, L.,Su, J.,Yu, S.,Yan, J.,Gao, F.,Zhang, G.,Qiu, H.J.,Gao, G.F.,Qi, J.,Wang, H.	The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives.	Proc.Natl.Acad.Sci.USA	2020	117	11000	11009	
6LQY		Crystal complex of endo-deglycosylated hydroxynitrile lyase isozyme 5 of Prunus communis with benzaldehyde	2020-01-15	2020-05-13	Zheng, Y.C.,Li, F.L.,Lin, Z.M.,Lin, G.Q.,Hong, R.,Yu, H.L.,Xu, J.H.	Structure-Guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes.	Acs Catalysis	2020	0	0	0	
6LR8		Mutant L331A of deglycosylated hydroxynitrile lyase isozyme 5 from Prunus communis	2020-01-15	2020-05-13	Zheng, Y.C.,Li, F.L.,Lin, Z.M.,Lin, G.Q.,Hong, R.,Yu, H.L.,Xu, J.H.	Structure-Guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes.	Acs Catalysis	2020	0	0	0	
6M3P	32353364	Crystal structure of AnkG/beta2-spectrin complex	2020-03-04	2020-05-13	Li, J.,Chen, K.,Zhu, R.,Zhang, M.	Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins.	J.Mol.Biol.	2020	432	3838	3850	
6M3R	32353364	Crystal structure of AnkG/beta4-spectrin complex	2020-03-04	2020-05-13	Li, J.,Chen, K.,Zhu, R.,Zhang, M.	Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins.	J.Mol.Biol.	2020	432	3838	3850	
7BOR	33010351	Structure of Pseudomonas aeruginosa CoA-bound OdaA	2020-03-19	2020-05-13	Zhao, N.L.,Zhang, Q.Q.,Zhao, C.,Liu, L.,Li, T.,Li, C.C.,He, L.H.,Zhu, Y.B.,Song, Y.J.,Liu, H.X.,Bao, R.	Structural and molecular dynamic studies of Pseudomonas aeruginosa OdaA reveal the regulation role of a C-terminal hinge element.	Biochim Biophys Acta Gen Subj	2020	1865	129756	129756	
7BOV	33152360	The Structure of Bacillus subtilis glycosyltransferase,Bs-YjiC	2020-03-20	2020-05-13	Liu, B.,Zhao, C.,Xiang, Q.,Zhao, N.,Luo, Y.,Bao, R.	Structural and biochemical studies of the glycosyltransferase Bs-YjiC from Bacillus subtilis.	Int.J.Biol.Macromol.	2021	166	806	817	
7BWP		Crystal complex of endo-deglycosylated PcHNL5 with (R)-mandelonitrile	2020-04-15	2020-05-13	Zheng, Y.C.,Li, F.L.,Lin, Z.M.,Lin, G.Q.,Hong, R.,Yu, H.L.,Xu, J.H.	Structure-Guided Tuning of a Hydroxynitrile Lyase to Accept Rigid Pharmaco Aldehydes.	Acs Catalysis	2020	0	0	0	
6JDZ		Ligand complex structure of GH10 family xylanase XynAF1, soaking for 20 minutes	2019-02-02	2020-05-20	Li, G.,Miao, Y.,Zhang, R.	Crystal structure of GH10 family xylanase XynAF1 from Aspergillus fumigatus Z5	To Be Published	0	0	0	0	
6JE0		Ligand complex structure of GH10 family xylanase XynAF1, soaking for 30 minutes	2019-02-02	2020-05-20	Li, G.,Miao, Y.,Zhang, R.	Crystal structure of GH10 family xylanase XynAF1 from Aspergillus fumigatus Z5	To Be Published	0	0	0	0	
6JE1		Ligand complex structure of GH10 family xylanase XynAF1, soaking for 40 minutes	2019-02-02	2020-05-20	Li, G.,Miao, Y.,Zhang, R.	Crystal structure of GH10 family xylanase XynAF1 from Aspergillus fumigatus Z5	To Be Published	0	0	0	0	
6JE2		Ligand complex structure of GH10 family xylanase XynAF1, soaking for 80 minutes	2019-02-02	2020-05-20	Li, G.,Miao, Y.,Zhang, R.	Crystal structure of GH10 family xylanase XynAF1 from Aspergillus fumigatus Z5	To Be Published	0	0	0	0	
6JMT	32780989	Crystal structure of GIT/PIX complex	2019-03-13	2020-05-20	Zhu, J.,Zhou, Q.,Xia, Y.,Lin, L.,Li, J.,Peng, M.,Zhang, R.,Zhang, M.	GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.	Mol.Cell	2020	79	782	0	
6JMU	32780989	Crystal structure of GIT1/Paxillin complex	2019-03-13	2020-05-20	Zhu, J.,Zhou, Q.,Xia, Y.,Lin, L.,Li, J.,Peng, M.,Zhang, R.,Zhang, M.	GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.	Mol.Cell	2020	79	782	0	
6K0Z		Substrate bound state of Staphylococcus Aureus AldH	2019-05-08	2020-05-20	Tao, X.,Zhang, Z.,Zhang, X.,Li, H.,Sun, H.,Mao, Z.,Xia, W.	Structural Insight into the Substrate Gating Mechanism by Staphylococcus aureus Aldehyde Dehydrogenase	CCS Chemistry	2020	2	946	954	
6K10		Non substrate bound state of Staphylococcus Aureus AldH	2019-05-08	2020-05-20	Tao, X.,Zhang, Z.,Zhang, X.,Li, H.,Sun, H.,Mao, Z.,Xia, W.	Structural Insight into the Substrate Gating Mechanism by Staphylococcus aureus Aldehyde Dehydrogenase	CCS Chemistry	2020	2	946	954	
7C22	35006385	Crystal structure of the C-terminal domain of SARS-CoV-2 nucleocapsid protein	2020-05-07	2020-05-20	Zhou, R.,Zeng, R.,von Brunn, A.,Lei, J.	Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein.	Mol Biomed	2020	1	2	2	
7C23	32549911	Crystal structure of CrmE10, a SGNH-hydrolase family esterase	2020-05-07	2020-05-20	Li, Z.,Li, L.,Huo, Y.,Chen, Z.,Zhao, Y.,Huang, J.,Jian, S.,Rong, Z.,Wu, D.,Gan, J.,Hu, X.,Li, J.,Xu, X.W.	Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases.	Biotechnol Biofuels	2020	13	107	107	
7C29	32549911	Esterase CrmE10 mutant-D178A	2020-05-07	2020-05-20	Li, Z.,Li, L.,Huo, Y.,Chen, Z.,Zhao, Y.,Huang, J.,Jian, S.,Rong, Z.,Wu, D.,Gan, J.,Hu, X.,Li, J.,Xu, X.W.	Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases.	Biotechnol Biofuels	2020	13	107	107	
6KI3	32194979	The crystal structure of AsfvAP:dF commplex	2019-07-17	2020-05-27	Chen, Y.,Chen, X.,Huang, Q.,Shao, Z.,Gao, Y.,Li, Y.,Yang, C.,Liu, H.,Li, J.,Wang, Q.,Ma, J.,Zhang, Y.Z.,Gu, Y.,Gan, J.	A unique DNA-binding mode of African swine fever virus AP endonuclease.	Cell Discov	2020	6	13	13	
6LS5	32375478	Structure of human liver FBPase complexed with covalent allosteric inhibitor	2020-01-17	2020-05-27	Huang, Y.,Xu, Y.,Song, R.,Ni, S.,Liu, J.,Xu, Y.,Ren, Y.,Rao, L.,Wang, Y.,Wei, L.,Feng, L.,Su, C.,Peng, C.,Li, J.,Wan, J.	Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.	J.Med.Chem.	2020	63	6238	6247	
7C2I	32728018	Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization)	2020-05-07	2020-05-27	Lin, S.,Chen, H.,Ye, F.,Chen, Z.,Yang, F.,Zheng, Y.,Cao, Y.,Qiao, J.,Yang, S.,Lu, G.	Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.	Signal Transduct Target Ther	2020	5	131	131	
7C2J	32728018	Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (without additional SAM during crystallization)	2020-05-07	2020-05-27	Lin, S.,Chen, H.,Ye, F.,Chen, Z.,Yang, F.,Zheng, Y.,Cao, Y.,Qiao, J.,Yang, S.,Lu, G.	Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.	Signal Transduct Target Ther	2020	5	131	131	
6K34		Crystal Structure of DphMB1	2019-05-16	2020-06-03	Fan, S.	Crystal Structure of DphMB1	To Be Published	0	0	0	0	
6LQE	32358072	Crystal structure of Arabidopsis ARID5 PHD finger in complex with H3K4me3 peptide	2020-01-13	2020-06-03	Tan, L.M.,Liu, R.,Gu, B.W.,Zhang, C.J.,Luo, J.,Guo, J.,Wang, Y.,Chen, L.,Du, X.,Li, S.,Shao, C.R.,Su, Y.N.,Cai, X.W.,Lin, R.N.,Li, L.,Chen, S.,Du, J.,He, X.J.	Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis.	Plant Cell	2020	32	2178	2195	
6LQF	32358072	Crystal structure of Arabidopsis ARID5 ARID-PHD cassette in complex with H3K4me3 peptide and DNA	2020-01-13	2020-06-03	Tan, L.M.,Liu, R.,Gu, B.W.,Zhang, C.J.,Luo, J.,Guo, J.,Wang, Y.,Chen, L.,Du, X.,Li, S.,Shao, C.R.,Su, Y.N.,Cai, X.W.,Lin, R.N.,Li, L.,Chen, S.,Du, J.,He, X.J.	Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis.	Plant Cell	2020	32	2178	2195	
6K7S		Crystal structure of thymidylate synthase from shrimp	2019-06-08	2020-06-10	Liu, C.,Zang, K.,Li, S.,Li, F.,Ma, Q.	Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed.	J Oceanol Limnol	2020	38	1891	1899	
6KKO	32090355	The crystal structure of SiaB-SiaC complex from Pseudomonas aeruginosa	2019-07-26	2020-06-10	Chen, G.K.,Gan, J.H.,Yang, C.,Zuo, Y.L.,Peng, J.,Li, M.,Huo, W.P.,Xie, Y.P.,Zhang, Y.N.,Wang, T.T.,Deng, X.,Liang, H.H.	The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa.	Embo J.	2020	39	0	0	
6L4R	32353513	Crystal structure of Enterovirus D68 RdRp	2019-10-21	2020-06-10	Li, L.,Wang, M.,Chen, Y.,Hu, T.,Yang, Y.,Zhang, Y.,Bi, G.,Wang, W.,Liu, E.,Han, J.,Lu, T.,Su, D.	Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.	J.Struct.Biol.	2020	211	107510	107510	
6L8I	32513704	Crystal structure of CYP97A3 mutant S290D/W300L/S304V	2019-11-06	2020-06-10	Niu, G.,Guo, Q.,Wang, J.,Zhao, S.,He, Y.,Liu, L.	Structural basis for plant lutein biosynthesis from alpha-carotene.	Proc.Natl.Acad.Sci.USA	2020	117	14150	14157	
6L8J	32513704	Crystal structure of CYP97A3 mutant S290D/W300L/S304V in complex with retinal	2019-11-06	2020-06-10	Niu, G.,Guo, Q.,Wang, J.,Zhao, S.,He, Y.,Liu, L.	Structural basis for plant lutein biosynthesis from alpha-carotene.	Proc.Natl.Acad.Sci.USA	2020	117	14150	14157	
6K8E		Global regulatory element SarX	2019-06-11	2020-06-17	Wang, Q.	Crystal structure of SarX from Staphylococcus aureus	To Be Published	0	0	0	0	
6L5N	32714761	Crystal structure of human DEAD-box RNA helicase DDX21 at post-unwound state	2019-10-24	2020-06-17	Chen, Z.,Li, Z.,Hu, X.,Xie, F.,Kuang, S.,Zhan, B.,Gao, W.,Chen, X.,Gao, S.,Li, Y.,Wang, Y.,Qian, F.,Ding, C.,Gan, J.,Ji, C.,Xu, X.,Zhou, Z.,Huang, J.,He, H.H.,Li, J.	Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.	Adv Sci	2020	7	2000532	2000532	
6LS9	32426511	Crystal structure of bovine herpesvirus 1 glycoprotein D	2020-01-17	2020-06-17	Yue, D.,Chen, Z.,Yang, F.,Ye, F.,Lin, S.,He, B.,Cheng, Y.,Wang, J.,Chen, Z.,Lin, X.,Yang, J.,Chen, H.,Zhang, Z.,You, Y.,Sun, H.,Wen, A.,Wang, L.,Zheng, Y.,Cao, Y.,Li, Y.,Lu, G.	Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.	Sci Adv	2020	6	0	0	
6LSA	32426511	Complex structure of bovine herpesvirus 1 glycoprotein D and bovine nectin-1 IgV	2020-01-17	2020-06-17	Yue, D.,Chen, Z.,Yang, F.,Ye, F.,Lin, S.,He, B.,Cheng, Y.,Wang, J.,Chen, Z.,Lin, X.,Yang, J.,Chen, H.,Zhang, Z.,You, Y.,Sun, H.,Wen, A.,Wang, L.,Zheng, Y.,Cao, Y.,Li, Y.,Lu, G.	Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.	Sci Adv	2020	6	0	0	
7BTC	32470140	Crystal structure of Rheb Y35N mutant bound to GDP	2020-04-01	2020-06-17	Zhang, C.,Liu, Y.,Zhang, Y.,Wang, X.,Zhang, T.,Ding, J.	Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.	J Mol Cell Biol	2020	12	741	744	
7BTD	32470140	Crystal structure of Rheb Y35N mutant bound to GppNHp	2020-04-01	2020-06-17	Zhang, C.,Liu, Y.,Zhang, Y.,Wang, X.,Zhang, T.,Ding, J.	Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.	J Mol Cell Biol	2020	12	741	744	
6K9N		Rice_OTUB_like_catalytic domain	2019-06-17	2020-06-24	Lu, L.,Zhai, X.,Li, X.,Wang, S.,Zhang, L.,Wang, L.,Jin, X.,Liang, L.,Deng, Z.,Li, Z.,Wang, Y.,Fu, X.,Hu, H.,Wang, J.,Mei, Z.,He, Z.,Wang, F.	Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains	Nat Commun	2022	13	4672	0	
6K9P		Structure of Deubiquitinase	2019-06-17	2020-06-24	Lu, L.,Zhai, X.,Li, X.,Wang, S.,Zhang, L.,Wang, L.,Jin, X.,Liang, L.,Deng, Z.,Li, Z.,Wang, Y.,Fu, X.,Hu, H.,Wang, J.,Mei, Z.,He, Z.,Wang, F.	Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains	Nat Commun	2022	13	4672	0	
6KBE		Structure of Deubiquitinase	2019-06-24	2020-06-24	Lu, L.,Zhai, X.,Li, X.,Wang, S.,Zhang, L.,Wang, L.,Jin, X.,Liang, L.,Deng, Z.,Li, Z.,Wang, Y.,Fu, X.,Hu, H.,Wang, J.,Mei, Z.,He, Z.,Wang, F.	Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains	Nat Commun	2022	13	4672	0	
7C8V	34330908	Structure of sybody SR4 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD)	2020-06-03	2020-06-24	Li, T.,Cai, H.,Yao, H.,Zhou, B.,Zhang, N.,van Vlissingen, M.F.,Kuiken, T.,Han, W.,GeurtsvanKessel, C.H.,Gong, Y.,Zhao, Y.,Shen, Q.,Qin, W.,Tian, X.X.,Peng, C.,Lai, Y.,Wang, Y.,Hutter, C.A.J.,Kuo, S.M.,Bao, J.,Liu, C.,Wang, Y.,Richard, A.S.,Raoul, H.,Lan, J.,Seeger, M.A.,Cong, Y.,Rockx, B.,Wong, G.,Bi, Y.,Lavillette, D.,Li, D.	A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.	Nat Commun	2021	12	4635	4635	
7C8W	34330908	Structure of sybody MR17 in complex with the SARS-CoV-2 S receptor-binding domain (RBD)	2020-06-03	2020-06-24	Li, T.,Cai, H.,Yao, H.,Zhou, B.,Zhang, N.,van Vlissingen, M.F.,Kuiken, T.,Han, W.,GeurtsvanKessel, C.H.,Gong, Y.,Zhao, Y.,Shen, Q.,Qin, W.,Tian, X.X.,Peng, C.,Lai, Y.,Wang, Y.,Hutter, C.A.J.,Kuo, S.M.,Bao, J.,Liu, C.,Wang, Y.,Richard, A.S.,Raoul, H.,Lan, J.,Seeger, M.A.,Cong, Y.,Rockx, B.,Wong, G.,Bi, Y.,Lavillette, D.,Li, D.	A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.	Nat Commun	2021	12	4635	4635	
7CAN	34330908	Structure of sybody MR17-K99Y in complex with the SARS-CoV-2 S Receptor-binding domain (RBD)	2020-06-09	2020-06-24	Li, T.,Cai, H.,Yao, H.,Zhou, B.,Zhang, N.,van Vlissingen, M.F.,Kuiken, T.,Han, W.,GeurtsvanKessel, C.H.,Gong, Y.,Zhao, Y.,Shen, Q.,Qin, W.,Tian, X.X.,Peng, C.,Lai, Y.,Wang, Y.,Hutter, C.A.J.,Kuo, S.M.,Bao, J.,Liu, C.,Wang, Y.,Richard, A.S.,Raoul, H.,Lan, J.,Seeger, M.A.,Cong, Y.,Rockx, B.,Wong, G.,Bi, Y.,Lavillette, D.,Li, D.	A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.	Nat Commun	2021	12	4635	4635	
6KBH		Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase	2019-06-25	2020-07-01	Gong, R.,Wu, L.J.,Zhang, Y.,Liu, Z.,Dou, S.,Zhang, R.G.,Xu, J.H.,Tang, C.,Zhou, J.H.	Crystal structure of an intact type IV self-sufficient cytochrome P450 monooxygenase	To Be Published	0	0	0	0	
6KC0	33352158	fused To-MtbCsm1 with 2ATP	2019-06-26	2020-07-01	Zhang, S.,Li, T.,Huo, Y.,Yang, J.,Fleming, J.,Shi, M.,Wang, Y.,Wei, W.,Gu, S.,Bi, L.,Jiang, T.,Zhang, H.	Mycobacterium tuberculosis CRISPR/Cas system Csm1 holds clues to the evolutionary relationship between DNA polymerase and cyclase activity.	Int.J.Biol.Macromol.	2020	170	140	149	
6KCO		Shuguo PWWP in complex with ssDNA	2019-06-28	2020-07-01	Liu, Y.C.,Huang, Y.	Shuguo PWWP in complex with ssDNA	To Be Published	0	0	0	0	
6KCP		Shuguo PWWP in complex with ssDNA	2019-06-28	2020-07-01	Liu, Y.C.,Huang, Y.	Shuguo PWWP in complex with ssDNA	To Be Published	0	0	0	0	
6KEY	33862200	Structural basis for the regulation of inducible nitric oxide synthase (iNOS) by the SPRY domain-containing SOCS box protein 2 (SPSB2)	2019-07-05	2020-07-01	Li, K.,You, T.,Zhao, P.,Luo, Y.,Zhang, D.,Wei, H.,Wang, Y.,Yang, J.,Guan, X.,Kuang, Z.	Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase.	Nitric Oxide	2021	0	1	6	
6KRI	32601219	Crystal Structure of Acyl-CoA Dehydrogenase FadE5 from Mycobacteria smegmatis with product released	2019-08-21	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6KS9	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis	2019-08-23	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6KSB	32601219	Crystal Structure of E447A M130G Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C16CoA	2019-08-23	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6KSE	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria tuberculosisin complex with C18CoA	2019-08-23	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LPY	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C4CoA	2020-01-12	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ0	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C6CoA	2020-01-12	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ1	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C8CoA	2020-01-12	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ2	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C10CoA	2020-01-12	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ3	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C12CoA	2020-01-12	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ4	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C14CoA	2020-01-13	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ5	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C16CoA	2020-01-13	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ6	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C20CoA	2020-01-13	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6LQ7	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C17CoA	2020-01-13	2020-07-01	Chen, X.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
6KED		BRD4 Bromodomain1 with an inhibitor	2019-07-04	2020-07-08	Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C.	BRD4 Bromodomain1 with an inhibitor	To Be Published	0	0	0	0	
6KEF		BRD4 Bromodomain1 with an inhibitor	2019-07-04	2020-07-08	Xiao, S.,Li, Z.,Chen, S.,Zhou, B.,Luo, C.	BRD4 Bromodomain1 with an inhibitor	To Be Published	0	0	0	0	
6KF1		Microbial Hormone-sensitive lipase- E53 mutant S162A	2019-07-05	2020-07-08	Xiaochen, Y.,Yingyi, H.,Zhengyang, L.,Shuling, J.,Zhen, R.,Zhao, W.,Xiaojian, H.,Henglin, C.,Jixi, L.,Xuewei, X.	Functional and Structural Insights into Environmental Adaptation of a Novel Hormone-sensitive Lipase, E53, Obtained from Erythrobacter longus	To Be Published	0	0	0	0	
6KF5		Microbial Hormone-sensitive lipase E53 mutant I256L	2019-07-06	2020-07-08	Yang, X.,Yingyi, H.,Li, Z.Y.,Shuling, J.,Zhen, R.,Zhao, W.,Xiaojian, H.,Henglin, C.,Li, J.,Xu, X.W.	Microbial Hormone-sensitive lipase E53 mutant I256L	To Be Published	0	0	0	0	
6KF7		Microbial Hormone-sensitive lipase E53 mutant S285G	2019-07-06	2020-07-08	Xiaochen, Y.	Microbial Hormone-sensitive lipase E53 mutant S285G	To Be Published	0	0	0	0	
6KFL		Crystal structure of a two-quartet DNA G-quadruplex complexed with the porphyrin TMPyP4	2019-07-08	2020-07-08	Zhang, Y.S.,Parkinson, G.N.,Wei, D.G.	Crystal structure of a two-quartet DNA G-quadruplex complexed with the porphyrin TMPyP4	To Be Published	0	0	0	0	
6KGC	33097546	Crystal structure of CaDoc0917(R49D)-CaCohA2 complex at pH 5.4	2019-07-11	2020-07-08	Yao, X.,Chen, C.,Wang, Y.,Dong, S.,Liu, Y.J.,Li, Y.,Cui, Z.,Gong, W.,Perrett, S.,Yao, L.,Lamed, R.,Bayer, E.A.,Cui, Q.,Feng, Y.	Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules.	Sci Adv	2020	6	0	0	
6KGF	33097546	Crystal structure of CaDoc0917(R16D)-CaCohA2 complex at pH 8.2	2019-07-11	2020-07-08	Yao, X.,Chen, C.,Wang, Y.,Dong, S.,Liu, Y.J.,Li, Y.,Cui, Z.,Gong, W.,Perrett, S.,Yao, L.,Lamed, R.,Bayer, E.A.,Cui, Q.,Feng, Y.	Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules.	Sci Adv	2020	6	0	0	
6KN5	32265480	Crystal structure of AFF4 C-terminal domain	2019-08-03	2020-07-08	Gao, Y.,Chen, L.,Han, Y.,Wu, F.,Yang, W.S.,Zhang, Z.,Huo, T.,Zhu, Y.,Yu, C.,Kim, H.,Lee, M.,Tang, Z.,Phillips, K.,He, B.,Jung, S.Y.,Song, Y.,Zhu, B.,Xu, R.M.,Feng, Q.	Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha.	Commun Biol	2020	3	165	165	
6KOK	32561432	Crystal Structure of SNX11/SNX10-PXe Chimera	2019-08-11	2020-07-08	Xu, T.,Gan, Q.,Wu, B.,Yin, M.,Xu, J.,Shu, X.,Liu, J.	Molecular Basis for PI(3,5)P2Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation.	J.Mol.Biol.	2020	432	4750	4761	
6KTR	32061104	Crystal structure of fibroblast growth factor 19 in complex with Fab	2019-08-28	2020-07-08	Liu, H.,Zheng, S.,Hou, X.,Liu, X.,Du, K.,Lv, X.,Li, Y.,Yang, F.,Li, W.,Sui, J.	Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects.	Cancer Sci.	2020	111	1750	1760	
6M24	32522857	Uncommon structural features of rabbit MHC class I (RLA-A1) complexed with rabbit haemorrhagic disease virus (RHDV) derived peptide, VP60-2	2020-02-26	2020-07-08	Zhang, Q.,Liu, K.,Yue, C.,Zhang, D.,Lu, D.,Xiao, W.,Liu, P.,Zhao, Y.,Gao, G.,Ding, C.,Lyu, J.,Liu, W.J.	Strict Assembly Restriction of Peptides from Rabbit Hemorrhagic Disease Virus Presented by Rabbit Major Histocompatibility Complex Class I Molecule RLA-A1.	J.Virol.	2020	94	0	0	
6M2J	32522857	Uncommon structural features of rabbit MHC class I (RLA-A1) complexed with rabbit haemorrhagic disease virus (RHDV) derived peptide, VP60-1	2020-02-27	2020-07-08	Zhang, Q.,Liu, K.,Yue, C.,Zhang, D.,Lu, D.,Xiao, W.,Liu, P.,Zhao, Y.,Gao, G.,Ding, C.,Lyu, J.,Liu, W.J.	Strict Assembly Restriction of Peptides from Rabbit Hemorrhagic Disease Virus Presented by Rabbit Major Histocompatibility Complex Class I Molecule RLA-A1.	J.Virol.	2020	94	0	0	
6M2K	32522857	Uncommon structural features of rabbit MHC class I (RLA-A1) complexed with rabbit haemorrhagic disease virus (RHDV) derived peptide, VP60-10	2020-02-27	2020-07-08	Zhang, Q.,Liu, K.,Yue, C.,Zhang, D.,Lu, D.,Xiao, W.,Liu, P.,Zhao, Y.,Gao, G.,Ding, C.,Lyu, J.,Liu, W.J.	Strict Assembly Restriction of Peptides from Rabbit Hemorrhagic Disease Virus Presented by Rabbit Major Histocompatibility Complex Class I Molecule RLA-A1.	J.Virol.	2020	94	0	0	
7CC9	32621606	Sulfur binding domain of SprMcrA complexed with phosphorothioated DNA	2020-06-16	2020-07-08	Yu, H.,Li, J.,Liu, G.,Zhao, G.,Wang, Y.,Hu, W.,Deng, Z.,Wu, G.,Gan, J.,Zhao, Y.L.,He, X.	DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses.	Nucleic Acids Res.	2020	48	8755	8766	
7CCJ	32621606	Sulfur binding domain of SprMcrA complexed with phosphorothioated DNA	2020-06-17	2020-07-08	Yu, H.,Li, J.,Liu, G.,Zhao, G.,Wang, Y.,Hu, W.,Deng, Z.,Wu, G.,Gan, J.,Zhao, Y.L.,He, X.	DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses.	Nucleic Acids Res.	2020	48	8755	8766	
6KFT	33883894	MVM NS2 mutant Nm42 in complex with CRM1-Ran-RanBP1	2019-07-08	2020-07-15	Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q.	Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.	Int J Nanomedicine	2021	16	2833	2847	
6KHN	32595985	Crystal structure of Oryza sativa TDC with PLP and SEROTONIN	2019-07-16	2020-07-15	Zhou, Y.,Liao, L.,Liu, X.,Liu, B.,Chen, X.,Guo, Y.,Huang, C.,Zhao, Y.,Zeng, Z.	Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.	J Adv Res	2020	24	501	511	
6KHP	32595985	Crystal structure of Oryza sativa TDC with PLP and tryptamine	2019-07-16	2020-07-15	Zhou, Y.,Liao, L.,Liu, X.,Liu, B.,Chen, X.,Guo, Y.,Huang, C.,Zhao, Y.,Zeng, Z.	Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.	J Adv Res	2020	24	501	511	
6LB7	32790952	Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex	2019-11-13	2020-07-15	Wu, W.,Shen, Q.,Zhang, R.,Qiu, Z.,Wang, Y.,Zheng, J.,Jia, Z.	The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.	Embo J.	2020	39	0	0	
6LB8	32790952	Crystal structure of the Ca2+-free T4L-MICU1-MICU2 complex	2019-11-13	2020-07-15	Wu, W.,Shen, Q.,Zhang, R.,Qiu, Z.,Wang, Y.,Zheng, J.,Jia, Z.	The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.	Embo J.	2020	39	0	0	
6KII	31675429	photolyase from Arthrospira platensis	2019-07-18	2020-07-22	Yan, H.,Zhu, K.,Teng, M.,Li, X.	A newly identified photolyase from Arthrospira platensis possesses a unique methenyltetrahydrofolate chromophore-binding pattern.	Febs Lett.	2020	594	740	750	
6KIT		Structure of mouse CXorf40A, Selenomethionine derivative	2019-07-19	2020-07-22	Wu, B.X.	Structure of mouse CXorf40A, Selenomethionine derivative	To Be Published	0	0	0	0	
6LBK	32633758	Structure of rat GLD-2 (Terminal nucleotidyltransferase 2, TENT2)	2019-11-14	2020-07-22	Ma, X.Y.,Zhang, H.,Feng, J.X.,Hu, J.L.,Yu, B.,Luo, L.,Cao, Y.L.,Liao, S.,Wang, J.,Gao, S.	Structures of mammalian GLD-2 proteins reveal molecular basis of their functional diversity in mRNA and microRNA processing.	Nucleic Acids Res.	2020	48	8782	8795	
6LKV	32484230	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum	2019-12-20	2020-07-22	Su, Z.,Tian, X.,Li, H.,Wei, Z.,Chen, L.,Wang, S.,Ren, H.,Peng, W.,Tang, C.,Lin, T.,Huang, S.	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.	Biochem.J.	2020	477	2133	2151	
6LKW	32484230	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum	2019-12-20	2020-07-22	Su, Z.,Tian, X.,Li, H.,Wei, Z.,Chen, L.,Wang, S.,Ren, H.,Peng, W.,Tang, C.,Lin, T.,Huang, S.	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum.	Biochem.J.	2020	477	2133	2151	
6V97	32649767	Kindlin-3 double deletion mutant short form	2019-12-13	2020-07-22	Sun, J.,Xiao, D.,Ni, Y.,Zhang, T.,Cao, Z.,Xu, Z.,Nguyen, H.,Zhang, J.,White, G.C.,Ding, J.,Ma, Y.Q.,Xu, Z.	Structure basis of the FERM domain of kindlin-3 in supporting integrin alpha IIb beta 3 activation in platelets.	Blood Adv	2020	4	3128	3135	
6V9G	32649767	Kindlin-3 double deletion mutant long form	2019-12-13	2020-07-22	Sun, J.,Xiao, D.,Ni, Y.,Zhang, T.,Cao, Z.,Xu, Z.,Nguyen, H.,Zhang, J.,White, G.C.,Ding, J.,Ma, Y.Q.,Xu, Z.	Structure basis of the FERM domain of kindlin-3 in supporting integrin alpha IIb beta 3 activation in platelets.	Blood Adv	2020	4	3128	3135	
7BRE	32697937	The crystal structure of MLL2 in complex with ASH2L and RBBP5	2020-03-28	2020-07-22	Li, Y.,Zhao, L.,Tian, X.,Peng, C.,Gong, F.,Chen, Y.	Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.	Structure	2020	28	1141	0	
6KKG		Crystal structure of MAGI2-Dendrin complex	2019-07-25	2020-07-29	Zhang, H.J.,Lin, L.,Lin, Z.J.,Liu, J.P.,Pan, L.F.,Zhang, M.J.,Zhu, J.W.,Zhang, R.G.	Phase separation of MAGI2-mediated complex underlies formation of slit diaphragm complex in glomerular filtration barrier	To Be Published	0	0	0	0	
6KKL	33280821	Crystal structure of Drug:Proton Antiporter-1 (DHA1) Family SotB, in the inward conformation (H115N mutant)	2019-07-26	2020-07-29	Xiao, Q.,Sun, B.,Zhou, Y.,Wang, C.,Guo, L.,He, J.,Deng, D.	Visualizing the nonlinear changes of a drug-proton antiporter from inward-open to occluded state.	Biochem.Biophys.Res.Commun.	2021	534	272	278	
7C7P	33602867	Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir	2020-05-26	2020-07-29	Qiao, J.,Li, Y.S.,Zeng, R.,Liu, F.L.,Luo, R.H.,Huang, C.,Wang, Y.F.,Zhang, J.,Quan, B.,Shen, C.,Mao, X.,Liu, X.,Sun, W.,Yang, W.,Ni, X.,Wang, K.,Xu, L.,Duan, Z.L.,Zou, Q.C.,Zhang, H.L.,Qu, W.,Long, Y.H.,Li, M.H.,Yang, R.C.,Liu, X.,You, J.,Zhou, Y.,Yao, R.,Li, W.P.,Liu, J.M.,Chen, P.,Liu, Y.,Lin, G.F.,Yang, X.,Zou, J.,Li, L.,Hu, Y.,Lu, G.W.,Li, W.M.,Wei, Y.Q.,Zheng, Y.T.,Lei, J.,Yang, S.	SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.	Science	2021	371	1374	1378	
6KYT	32485099	The structure of the M. tb toxin MazEF-mt1 complex	2019-09-20	2020-08-05	Chen, R.,Zhou, J.,Sun, R.,Du, C.,Xie, W.	Conserved Conformational Changes in the Regulation ofMycobacterium tuberculosisMazEF-mt1.	Acs Infect Dis.	2020	6	1783	1795	
6LLW	32699169	Crystal Structure of Fagopyrum esculentum M UGT708C1 complexed with UDP	2019-12-23	2020-08-05	Liu, M.,Wang, D.,Li, Y.,Li, X.,Zong, G.,Fei, S.,Yang, X.,Lin, J.,Wang, X.,Shen, Y.	Crystal Structures of theC-Glycosyltransferase UGT708C1 from Buckwheat Provide Insights into the Mechanism ofC-Glycosylation.	Plant Cell	2020	32	2917	2931	
6L2M	32270856	The structure of the tRNA-specific deaminase mutant from M. capricolum	2019-10-05	2020-08-12	Liu, H.,Wu, S.,Ran, D.,Xie, W.	Structure of a tRNA-specific deaminase with compromised deamination activity.	Biochem.J.	2020	477	1483	1497	
6L6J		Structure of 6-hydroxypseudooxynicotine (6-HPON) amine oxidase (HisD) from Pseudomonas geniculata N1	2019-10-29	2020-08-12	Liu, G.Q.,Tang, H.Z.	Structure of 6-hydroxypseudooxynicotine (6-HPON) amine oxidase (HisD) from Pseudomonas geniculata N1	Appl.Environ.Microbiol.	2020	0	0	0	
6M4P	32908132	Cytochrome P450 monooxygenase StvP2 substrate-bound structure	2020-03-08	2020-08-12	Sun, G.,Hu, C.,Mei, Q.,Luo, M.,Chen, X.,Li, Z.,Liu, Y.,Deng, Z.,Zhang, Z.,Sun, Y.	Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis.	Nat Commun	2020	11	4501	4501	
6M4Q	32908132	Cytochrome P450 monooxygenase StvP2 substrate-free structure	2020-03-08	2020-08-12	Sun, G.,Hu, C.,Mei, Q.,Luo, M.,Chen, X.,Li, Z.,Liu, Y.,Deng, Z.,Zhang, Z.,Sun, Y.	Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis.	Nat Commun	2020	11	4501	4501	
6KPP	32085900	BNC105 in complex with tubulin	2019-08-15	2020-08-19	Wang, T.,Wu, C.,Wang, C.,Zhang, G.,Arnst, K.E.,Yao, Y.,Zhang, Z.,Wang, Y.,Pu, D.,Li, W.	Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.	Biochem.Biophys.Res.Commun.	2020	0	0	0	
6KX2	32714746	Crystal structure of GDP bound RhoA protein	2019-09-09	2020-08-19	Sun, Z.,Zhang, H.,Zhang, Y.,Liao, L.,Zhou, W.,Zhang, F.,Lian, F.,Huang, J.,Xu, P.,Zhang, R.,Lu, W.,Zhu, M.,Tao, H.,Yang, F.,Ding, H.,Chen, S.,Yue, L.,Zhou, B.,Zhang, N.,Tan, M.,Jiang, H.,Chen, K.,Liu, B.,Liu, C.,Dang, Y.,Luo, C.	Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.	Adv Sci	2020	7	2000098	2000098	
6UXX	32944135	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a	2019-11-08	2020-08-19	Palte, R.L.,Schneider, S.E.,Altman, M.D.,Hayes, R.P.,Kawamura, S.,Lacey, B.M.,Mansueto, M.S.,Reutershan, M.,Siliphaivanh, P.,Sondey, C.,Xu, H.,Xu, Z.,Ye, Y.,Machacek, M.R.	Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).	Acs Med.Chem.Lett.	2020	11	1688	1693	
7COM	33602867	Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121)	2020-08-04	2020-08-19	Qiao, J.,Li, Y.S.,Zeng, R.,Liu, F.L.,Luo, R.H.,Huang, C.,Wang, Y.F.,Zhang, J.,Quan, B.,Shen, C.,Mao, X.,Liu, X.,Sun, W.,Yang, W.,Ni, X.,Wang, K.,Xu, L.,Duan, Z.L.,Zou, Q.C.,Zhang, H.L.,Qu, W.,Long, Y.H.,Li, M.H.,Yang, R.C.,Liu, X.,You, J.,Zhou, Y.,Yao, R.,Li, W.P.,Liu, J.M.,Chen, P.,Liu, Y.,Lin, G.F.,Yang, X.,Zou, J.,Li, L.,Hu, Y.,Lu, G.W.,Li, W.M.,Wei, Y.Q.,Zheng, Y.T.,Lei, J.,Yang, S.	SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.	Science	2021	371	1374	1378	
6KRW		Crystal Structure of AtPTP1 at 1.4 angstrom	2019-08-22	2020-08-26	Zhao, Y.Y.,Wang, H.J.,Hu, J.,Tang, J.,Zhang, W.H.,He, Q.Q.,Deng, H.T.,Luo, Z.P.,Wang, J.,Wang, Z.X.,Wang, X.L.,Wu, J.W.	Crystal structure of AtPTP1 at 1.4 Angstroms	To Be Published	0	0	0	0	
6KRX		Crystal Structure of AtPTP1 at 1.7 angstrom	2019-08-22	2020-08-26	Zhao, Y.Y.,Wang, H.J.,Hu, J.,Tang, J.,Zhang, W.H.,He, Q.Q.,Deng, H.T.,Luo, Z.P.,Wang, J.,Wang, Z.X.,Wang, X.L.,Wu, J.W.	AtPTP1 positively mediates brassinosteroid signaling from receptor kinases to GSK3-like kinase BIN2	To Be Published	0	0	0	0	
6KU1		The structure of EanB/Y353A complex with ergothioneine	2019-08-30	2020-08-26	Cheng, R.,Wu, L.,Lai, R.,Peng, C.,Naowarojna, N.,Hu, W.,Li, X.,Whelan, S.A.,Lee, N.,Lopez, J.,Zhao, C.,Yong, Y.,Xue, J.,Jiang, X.,Grinstaff, M.W.,Deng, Z.,Chen, J.,Cui, Q.,Zhou, J.H.,Liu, P.	Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis	Acs Catalysis	2020	10	8981	8994	
6KU2		The structure of EanB/Y353A complex with ergothioneine covalent linked with persulfide Cys412	2019-08-30	2020-08-26	Cheng, R.,Wu, L.,Lai, R.,Peng, C.,Naowarojna, N.,Hu, W.,Li, X.,Whelan, S.A.,Lee, N.,Lopez, J.,Zhao, C.,Yong, Y.,Xue, J.,Jiang, X.,Grinstaff, M.W.,Deng, Z.,Chen, J.,Cui, Q.,Zhou, J.H.,Liu, P.	Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis	Acs Catalysis	2020	10	8981	8994	
6XNN	32820126	Crystal Structure of Mouse STING CTD complex with SR-717.	2020-07-03	2020-08-26	Chin, E.N.,Yu, C.,Vartabedian, V.F.,Jia, Y.,Kumar, M.,Gamo, A.M.,Vernier, W.,Ali, S.H.,Kissai, M.,Lazar, D.C.,Nguyen, N.,Pereira, L.E.,Benish, B.,Woods, A.K.,Joseph, S.B.,Chu, A.,Johnson, K.A.,Sander, P.N.,Martinez-Pena, F.,Hampton, E.N.,Young, T.S.,Wolan, D.W.,Chatterjee, A.K.,Schultz, P.G.,Petrassi, H.M.,Teijaro, J.R.,Lairson, L.L.	Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.	Science	2020	369	993	999	
6KU0	33158857	Crystal structure of MyoVa-GTD in complex with MICAL1-GTBM	2019-08-29	2020-09-02	Niu, F.,Sun, K.,Wei, W.,Yu, C.,Wei, Z.	F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis.	Sci Adv	2020	6	0	0	
7BUJ	32814054	mcGAS bound with pppGpG	2020-04-07	2020-09-02	Zhao, Z.,Ma, Z.,Wang, B.,Guan, Y.,Su, X.D.,Jiang, Z.	Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.	Cell Rep	2020	32	108053	108053	
7BUM	32814054	mcGAS bound with pGpA	2020-04-07	2020-09-02	Zhao, Z.,Ma, Z.,Wang, B.,Guan, Y.,Su, X.D.,Jiang, Z.	Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.	Cell Rep	2020	32	108053	108053	
7BUQ	32814054	mcGAS bound with 23-cGAMP	2020-04-07	2020-09-02	Zhao, Z.,Ma, Z.,Wang, B.,Guan, Y.,Su, X.D.,Jiang, Z.	Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.	Cell Rep	2020	32	108053	108053	
7BV4	32817423	Crystal structure of STX17 LIR region in complex with GABARAP	2020-04-09	2020-09-02	Li, Y.,Cheng, X.,Li, M.,Wang, Y.,Fu, T.,Zhou, Z.,Wang, Y.,Gong, X.,Xu, X.,Liu, J.,Pan, L.	Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.	Proc.Natl.Acad.Sci.USA	2020	117	21391	21402	
7C6S	32887884	Crystal structure of the SARS-CoV-2 main protease complexed with Boceprevir	2020-05-22	2020-09-02	Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F.	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.	Nat Commun	2020	11	4417	4417	
7C6U	32887884	Crystal structure of SARS-CoV-2 complexed with GC376	2020-05-22	2020-09-02	Fu, L.,Ye, F.,Feng, Y.,Yu, F.,Wang, Q.,Wu, Y.,Zhao, C.,Sun, H.,Huang, B.,Niu, P.,Song, H.,Shi, Y.,Li, X.,Tan, W.,Qi, J.,Gao, G.F.	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.	Nat Commun	2020	11	4417	4417	
7C8B		Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK	2020-05-29	2020-09-02	Qiao, J.X.,Zeng, R.,Wang, Y.F.,Li, Y.S.,Yao, R.,Zhou, Y.L.,Chen, P.,Lei, J.,Yang, S.Y.	Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK	To Be Published	0	0	0	0	
7CDZ	32914439	Crystal structure of 2019-nCoV nucleocapsid N-terminal domain (NTD) protein	2020-06-21	2020-09-02	Peng, Y.,Du, N.,Lei, Y.,Dorje, S.,Qi, J.,Luo, T.,Gao, G.F.,Song, H.	Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design.	Embo J.	2020	39	0	0	
7CE0	32914439	Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein	2020-06-21	2020-09-02	Peng, Y.,Du, N.,Lei, Y.,Dorje, S.,Qi, J.,Luo, T.,Gao, G.F.,Song, H.	Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design.	Embo J.	2020	39	0	0	
6KRG	32978402	Crystal structure of sfGFP Y182TMSiPhe	2019-08-21	2020-09-09	Liu, Q.,He, Q.T.,Lyu, X.,Yang, F.,Zhu, Z.L.,Xiao, P.,Yang, Z.,Zhang, F.,Yang, Z.Y.,Wang, X.Y.,Sun, P.,Wang, Q.W.,Qu, C.X.,Gong, Z.,Lin, J.Y.,Xu, Z.,Song, S.L.,Huang, S.M.,Guo, S.C.,Han, M.J.,Zhu, K.K.,Chen, X.,Kahsai, A.W.,Xiao, K.H.,Kong, W.,Li, F.H.,Ruan, K.,Li, Z.J.,Yu, X.,Niu, X.G.,Jin, C.W.,Wang, J.,Sun, J.P.	DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe.	Nat Commun	2020	11	4857	4857	
6KVA	33953162	Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope	2019-09-03	2020-09-09	Shi, X.,Wan, Y.,Wang, N.,Xiang, J.,Wang, T.,Yang, X.,Wang, J.,Dong, X.,Dong, L.,Yan, L.,Li, Y.,Liu, L.,Hou, S.,Zhong, Z.,Wilson, I.A.,Yang, B.,Yang, G.,Lerner, R.A.	Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.	Nat Commun	2021	12	2547	2547	
6KVA	33953162	Structure of anti-hCXCR2 abN48-2 in complex with its CXCR2 epitope	2019-09-03	2020-09-09	Shi, X.,Wan, Y.,Wang, N.,Xiang, J.,Wang, T.,Yang, X.,Wang, J.,Dong, X.,Dong, L.,Yan, L.,Li, Y.,Liu, L.,Hou, S.,Zhong, Z.,Wilson, I.A.,Yang, B.,Yang, G.,Lerner, R.A.	Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.	Nat Commun	2021	12	2547	2547	
6KVF	33953162	Structure of anti-hCXCR2 abN48 in complex with its CXCR2 epitope	2019-09-04	2020-09-09	Shi, X.,Wan, Y.,Wang, N.,Xiang, J.,Wang, T.,Yang, X.,Wang, J.,Dong, X.,Dong, L.,Yan, L.,Li, Y.,Liu, L.,Hou, S.,Zhong, Z.,Wilson, I.A.,Yang, B.,Yang, G.,Lerner, R.A.	Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.	Nat Commun	2021	12	2547	2547	
6KVF	33953162	Structure of anti-hCXCR2 abN48 in complex with its CXCR2 epitope	2019-09-04	2020-09-09	Shi, X.,Wan, Y.,Wang, N.,Xiang, J.,Wang, T.,Yang, X.,Wang, J.,Dong, X.,Dong, L.,Yan, L.,Li, Y.,Liu, L.,Hou, S.,Zhong, Z.,Wilson, I.A.,Yang, B.,Yang, G.,Lerner, R.A.	Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.	Nat Commun	2021	12	2547	2547	
6KVW		The complex structure of EanB/C339A/C370A and hercynine	2019-09-05	2020-09-09	Wu, L.,Liu, P.H.,Zhou, J.H.	The complex structure of EanB/C339A/C370A and hercynine	To Be Published	0	0	0	0	
6KVY		The structure of EanB/T414A complex with hercynine	2019-09-05	2020-09-09	Wu, L.,Liu, P.H.,Zhou, J.H.	The structure of EanB/T414A complex with hercynine	To Be Published	0	0	0	0	
6KVZ		The structure of EanB/T414V complex with hercynine	2019-09-05	2020-09-09	Wu, L.,Liu, P.H.,Zhou, J.H.	The structure of EanB/T414V complex with hercynine	To Be Published	0	0	0	0	
6KWN	33717070	Crystal structure of pSLA-1*1301(F99Y) complex with S-OIV-derived epitope NSDTVGWSW	2019-09-07	2020-09-09	Wei, X.,Wang, S.,Li, Z.,Li, Z.,Qu, Z.,Wang, S.,Zou, B.,Liang, R.,Xia, C.,Zhang, N.	Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism.	Front Immunol	2021	12	592447	592447	
6KYB	32809042	Crystal structure of Atg18 from Saccharomyces cerevisiae	2019-09-17	2020-09-09	Lei, Y.,Tang, D.,Liao, G.,Xu, L.,Liu, S.,Chen, Q.,Li, C.,Duan, J.,Wang, K.,Wang, J.,Sun, B.,Li, Z.,Dai, L.,Cheng, W.,Qi, S.,Lu, K.	The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae.	Cell.Mol.Life Sci.	2021	78	2131	2143	
6LLG	32699169	Crystal Structure of Fagopyrum esculentum M UGT708C1	2019-12-23	2020-09-09	Liu, M.,Wang, D.,Li, Y.,Li, X.,Zong, G.,Fei, S.,Yang, X.,Lin, J.,Wang, X.,Shen, Y.	Crystal Structures of theC-Glycosyltransferase UGT708C1 from Buckwheat Provide Insights into the Mechanism ofC-Glycosylation.	Plant Cell	2020	32	2917	2931	
6LLZ	32699169	Crystal Structure of Fagopyrum esculentum M UGT708C1 complexed with UDP-glucose	2019-12-24	2020-09-09	Liu, M.,Wang, D.,Li, Y.,Li, X.,Zong, G.,Fei, S.,Yang, X.,Lin, J.,Wang, X.,Shen, Y.	Crystal Structures of theC-Glycosyltransferase UGT708C1 from Buckwheat Provide Insights into the Mechanism ofC-Glycosylation.	Plant Cell	2020	32	2917	2931	
6M0V		Crsytal structure of streptococcus thermophilus Cas9 in complex with the GGAA PAM	2020-02-22	2020-09-09	Zhang, Y.,Zhang, H.,Xu, X.,Wang, Y.,Chen, W.,Wang, Y.,Wu, Z.,Tang, N.,Wang, Y.,Zhao, S.,Gan, J.,Ji, Q.	Catalytic-state structure and engineering of Streptococcus thermophilus Cas9	Nat Catal	2020	0	0	0	
6M0W		Crystal structure of Streptococcus thermophilus Cas9 in complex with the AGAA PAM	2020-02-23	2020-09-09	Zhang, Y.,Zhang, H.,Xu, X.,Wang, Y.,Chen, W.,Wang, Y.,Wu, Z.,Tang, N.,Wang, Y.,Zhao, S.,Gan, J.,Ji, Q.	Catalytic-state structure and engineering of Streptococcus thermophilus Cas9	Nat Catal	2020	0	0	0	
6M0X		Crystal structure of Streptococcus thermophilus Cas9 in complex with AGGA PAM	2020-02-23	2020-09-09	Zhang, Y.,Zhang, H.,Xu, X.,Wang, Y.,Chen, W.,Wang, Y.,Wu, Z.,Tang, N.,Wang, Y.,Zhao, S.,Gan, J.,Ji, Q.	Catalytic-state structure and engineering of Streptococcus thermophilus Cas9	Nat Catal	2020	0	0	0	
7CUA	32845304	The structure of YoeB dimer from Staphylococcus aureus	2020-08-21	2020-09-09	Xue, L.,Yue, J.,Ke, J.,Khan, M.H.,Wen, W.,Sun, B.,Zhu, Z.,Niu, L.	Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system.	Nucleic Acids Res.	2020	48	10527	10541	
6KTS	32197300	Structure of C34N126K/N36	2019-08-28	2020-09-16	Yu, D.,Su, Y.,Ding, X.,Zhu, Y.,Qin, B.,Chong, H.,Cui, S.,He, Y.	Structural and Functional Characterization of the Secondary Mutation N126K Selected by Various HIV-1 Fusion Inhibitors.	Viruses	2020	12	0	0	
6KXH	33004437	Alp1U_Y247F mutant in complex with Fluostatin C	2019-09-11	2020-09-16	Zhang, L.,De, B.C.,Zhang, W.,Mandi, A.,Fang, Z.,Yang, C.,Zhu, Y.,Kurtan, T.,Zhang, C.	Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha / beta-fold epoxide hydrolase Alp1U.	J.Biol.Chem.	2020	295	16987	16997	
6KXT		BON1-C2B	2019-09-12	2020-09-16	Wang, Q.C.,Jiang, M.Q.,Isupov, M.N.,Sun, L.F.,Wu, Y.K.	Crystal Structure of an Arabidopsis Copine providing insights into this protein family	To be published	0	0	0	0	
7CH4	32970990	Crystal structure of the SARS-CoV-2 S RBD in complex with BD-604 Fab	2020-07-05	2020-09-16	Du, S.,Cao, Y.,Zhu, Q.,Yu, P.,Qi, F.,Wang, G.,Du, X.,Bao, L.,Deng, W.,Zhu, H.,Liu, J.,Nie, J.,Zheng, Y.,Liang, H.,Liu, R.,Gong, S.,Xu, H.,Yisimayi, A.,Lv, Q.,Wang, B.,He, R.,Han, Y.,Zhao, W.,Bai, Y.,Qu, Y.,Gao, X.,Ji, C.,Wang, Q.,Gao, N.,Huang, W.,Wang, Y.,Xie, X.S.,Su, X.D.,Xiao, J.,Qin, C.	Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.	Cell	2020	183	1013	0	
7CRD	33010351	Structure of Pseudomonas aeruginosa OdaA	2020-08-13	2020-09-16	Zhao, N.L.,Zhang, Q.Q.,Zhao, C.,Liu, L.,Li, T.,Li, C.C.,He, L.H.,Zhu, Y.B.,Song, Y.J.,Liu, H.X.,Bao, R.	Structural and molecular dynamic studies of Pseudomonas aeruginosa OdaA reveal the regulation role of a C-terminal hinge element.	Biochim Biophys Acta Gen Subj	2020	1865	129756	129756	
7CX9		Crystal structure of the SARS-CoV-2 main protease in complex with INZ-1	2020-09-01	2020-09-16	Qiao, J.X.,Zeng, R.,Liu, X.L.,Nan, J.S.,Wang, Y.F.,Li, Y.S.,Lei, J.,Yang, S.Y.	Crystal structure of the SARS-CoV-2 main protease in complex with INZ-1	To Be Published	0	0	0	0	
7CZA	33097503	Hexachlorobenzene monooxygenase (HcbA1) from Nocardioides sp. strain PD653 complexed with FMN	2020-09-07	2020-09-16	Guo, Y.,Li, D.F.,Ji, H.,Zheng, J.,Zhou, N.Y.	Hexachlorobenzene Monooxygenase Substrate Selectivity and Catalysis: Structural and Biochemical Insights.	Appl.Environ.Microbiol.	2020	87	0	0	
6KAG	33024572	Crystal structure of the SMARCB1/SMARCC2 subcomplex	2019-06-22	2020-09-23	Chen, G.,Zhou, H.,Liu, B.,Wang, Y.,Zhao, J.,Giancotti, F.G.,Long, J.	A heterotrimeric SMARCB1-SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex.	Cell Discov	2020	6	66	66	
6KY5		Crystal structure of a hydrolase mutant	2019-09-16	2020-09-23	Cui, Y.L.,Chen, Y.C.,Liu, X.Y.,Dong, S.J.,Tian, Y.,Qiao, Y.X.,Mitra, R.,Han, J.,Li, C.L.,Han, X.,Liu, W.D.,Chen, Q.,Du, W.B.,Tang, S.Y.,Xiang, H.,Liu, H.Y.,Wu, B.	Computational redesign of PETase for plasticbiodegradation by GRAPE strategy.	Biorxiv	2020	0	0	0	
6KYQ		Crystal structure of DCLK1 Autoinhibited Kinase Domain	2019-09-20	2020-09-23	Cheng, L.,Yang, Z.,Guo, W.,Wu, C.,Liang, S.,Tong, A.,Cao, Z.,Thorne, R.F.,Yang, S.Y.,Yu, Y.,Chen, Q.	DCLK1 Autoinhibition and Activation in Tumorigenesis	Innovation (N Y)	2021	0	0	0	
6KYR		Crystal structure of DCLK1 mutant (P675L) Autoinhibited Kinase Domain	2019-09-20	2020-09-23	Cheng, L.,Yang, Z.,Guo, W.,Wu, C.,Liang, S.,Tong, A.,Cao, Z.,Thorne, R.F.,Yang, S.Y.,Yu, Y.,Chen, Q.	DCLK1 Autoinhibition and Activation in Tumorigenesis	Innovation (N Y)	2021	0	0	0	
6L0X	32885980	The First Tudor Domain of PHF20L1	2019-09-27	2020-09-23	Lv, M.,Gao, J.,Li, M.,Ma, R.,Li, F.,Liu, Y.,Liu, M.,Zhang, J.,Yao, X.,Wu, J.,Shi, Y.,Tang, Y.,Pan, Y.,Zhang, Z.,Ruan, K.	Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.	J Phys Chem Lett	2020	11	7932	7938	
6L10	32885980	PHF20L1 Tudor1 - MES	2019-09-27	2020-09-23	Lv, M.,Gao, J.,Li, M.,Ma, R.,Li, F.,Liu, Y.,Liu, M.,Zhang, J.,Yao, X.,Wu, J.,Shi, Y.,Tang, Y.,Pan, Y.,Zhang, Z.,Ruan, K.	Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.	J Phys Chem Lett	2020	11	7932	7938	
6L1C	32885980	Crystal Structure Of of PHF20L1 Tudor1 Y24L mutant	2019-09-28	2020-09-23	Lv, M.,Gao, J.,Li, M.,Ma, R.,Li, F.,Liu, Y.,Liu, M.,Zhang, J.,Yao, X.,Wu, J.,Shi, Y.,Tang, Y.,Pan, Y.,Zhang, Z.,Ruan, K.	Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.	J Phys Chem Lett	2020	11	7932	7938	
6L1F	32885980	Crystal structure of PHF20L1 Tudor1 in complex with K142me1 DNMT1	2019-09-29	2020-09-23	Lv, M.,Gao, J.,Li, M.,Ma, R.,Li, F.,Liu, Y.,Liu, M.,Zhang, J.,Yao, X.,Wu, J.,Shi, Y.,Tang, Y.,Pan, Y.,Zhang, Z.,Ruan, K.	Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.	J Phys Chem Lett	2020	11	7932	7938	
6L1I	32885980	Crystal Structure Of of PHF20L1 Tudor1 Y24W/Y29W mutant	2019-09-29	2020-09-23	Lv, M.,Gao, J.,Li, M.,Ma, R.,Li, F.,Liu, Y.,Liu, M.,Zhang, J.,Yao, X.,Wu, J.,Shi, Y.,Tang, Y.,Pan, Y.,Zhang, Z.,Ruan, K.	Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.	J Phys Chem Lett	2020	11	7932	7938	
6L1P	32885980	Crystal structure of PHF20L1 in complex with Hit 1	2019-09-29	2020-09-23	Lv, M.,Gao, J.,Li, M.,Ma, R.,Li, F.,Liu, Y.,Liu, M.,Zhang, J.,Yao, X.,Wu, J.,Shi, Y.,Tang, Y.,Pan, Y.,Zhang, Z.,Ruan, K.	Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.	J Phys Chem Lett	2020	11	7932	7938	
7BQF	32905778	Dimerization of SAV1 WW tandem	2020-03-24	2020-09-23	Lin, Z.,Xie, R.,Guan, K.,Zhang, M.	A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling.	Cell Rep	2020	32	108118	108118	
7BQG	32905778	Complex structure of SAV1 and Dendrin	2020-03-24	2020-09-23	Lin, Z.,Xie, R.,Guan, K.,Zhang, M.	A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling.	Cell Rep	2020	32	108118	108118	
7BZB	33367256	Crystal structure of plant sesterterpene synthase AtTPS18	2020-04-27	2020-09-23	Chen, Q.,Li, J.,Liu, Z.,Mitsuhashi, T.,Zhang, Y.,Liu, H.,Ma, Y.,He, J.,Shinada, T.,Sato, T.,Wang, Y.,Liu, H.,Abe, I.,Zhang, P.,Wang, G.	Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases.	Plant Commun.	2020	1	100051	100051	
7BZC	33367256	Crystal structure of plant sesterterpene synthase AtTPS18 complexed with farnesyl thiolodiphosphate (FSPP)	2020-04-27	2020-09-23	Chen, Q.,Li, J.,Liu, Z.,Mitsuhashi, T.,Zhang, Y.,Liu, H.,Ma, Y.,He, J.,Shinada, T.,Sato, T.,Wang, Y.,Liu, H.,Abe, I.,Zhang, P.,Wang, G.	Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases.	Plant Commun.	2020	1	100051	100051	
7CBB	32880431	Crystal structure of SbnC in the biosynthesis of staphyloferrin B	2020-06-11	2020-09-23	Tang, J.,Ju, Y.,Zhou, J.,Guo, J.,Gu, Q.,Xu, J.,Zhou, H.	Structural and Biochemical Characterization of SbnC as a Representative Type B Siderophore Synthetase.	Acs Chem.Biol.	2020	15	2731	2740	
6LP6	32496056	Crystal structure of human DHODH in complex with inhibitor 1214	2020-01-09	2020-09-30	Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y.	Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.	J.Med.Chem.	2020	63	7633	7652	
6LP7	32496056	Crystal structure of human DHODH in complex with inhibitor 0944	2020-01-09	2020-09-30	Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y.	Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.	J.Med.Chem.	2020	63	7633	7652	
6LP8	32496056	Crystal structure of human DHODH in complex with inhibitor 1243	2020-01-09	2020-09-30	Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y.	Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.	J.Med.Chem.	2020	63	7633	7652	
6LIT	32795533	Estrogen-related receptor beta(ERR2) in complex with BPA	2019-12-13	2020-10-07	Yao, B.,Zhang, S.,Wei, Y.,Tian, S.,Lu, Z.,Jin, L.,He, Y.,Xie, W.,Li, Y.	Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor beta.	J.Mol.Biol.	2020	432	5460	5472	
6LN4	32795533	Estrogen-related receptor beta(ERR2) in complex with PGC1a-2a	2019-12-28	2020-10-07	Yao, B.,Zhang, S.,Wei, Y.,Tian, S.,Lu, Z.,Jin, L.,He, Y.,Xie, W.,Li, Y.	Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor beta.	J.Mol.Biol.	2020	432	5460	5472	
7CBH	32980741	Crystal structure of threonyl-tRNA synthetase (ThrRS) from Salmonella enterica in complex with an inhibitor	2020-06-12	2020-10-07	Guo, J.,Chen, B.,Yu, Y.,Cheng, B.,Ju, Y.,Tang, J.,Cai, Z.,Gu, Q.,Xu, J.,Zhou, H.	Structure-guided optimization and mechanistic study of a class of quinazolinone-threonine hybrids as antibacterial ThrRS inhibitors.	Eur.J.Med.Chem.	2020	207	112848	112848	
7CLZ	33004437	Crystal structure of Alp1U W187F/Y247F in complex with fluostatin C	2020-07-22	2020-10-07	Zhang, L.,De, B.C.,Zhang, W.,Mandi, A.,Fang, Z.,Yang, C.,Zhu, Y.,Kurtan, T.,Zhang, C.	Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha / beta-fold epoxide hydrolase Alp1U.	J.Biol.Chem.	2020	295	16987	16997	
6KZ5	33087562	Crystal Structure Analysis of the Csn-B-bounded NUR77 Ligand binding Domain	2019-09-23	2020-10-14	Yang, P.B.,Hou, P.P.,Liu, F.Y.,Hong, W.B.,Chen, H.Z.,Sun, X.Y.,Li, P.,Zhang, Y.,Ju, C.Y.,Luo, L.J.,Wu, S.F.,Zhou, J.X.,Wang, Z.J.,He, J.P.,Li, L.,Zhao, T.J.,Deng, X.,Lin, T.,Wu, Q.	Blocking PPAR gamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.	Proc.Natl.Acad.Sci.USA	2020	117	27412	27422	
7BQO	32999480	The structure of HpiI in complex with its substrate analogue	2020-03-25	2020-10-14	Ohashi, M.,Jamieson, C.S.,Cai, Y.,Tan, D.,Kanayama, D.,Tang, M.C.,Anthony, S.M.,Chari, J.V.,Barber, J.S.,Picazo, E.,Kakule, T.B.,Cao, S.,Garg, N.K.,Zhou, J.,Houk, K.N.,Tang, Y.	An enzymatic Alder-ene reaction.	Nature	2020	586	64	69	
7BQO	32999480	The structure of HpiI in complex with its substrate analogue	2020-03-25	2020-10-14	Ohashi, M.,Jamieson, C.S.,Cai, Y.,Tan, D.,Kanayama, D.,Tang, M.C.,Anthony, S.M.,Chari, J.V.,Barber, J.S.,Picazo, E.,Kakule, T.B.,Cao, S.,Garg, N.K.,Zhou, J.,Houk, K.N.,Tang, Y.	An enzymatic Alder-ene reaction.	Nature	2020	586	64	69	
7CCB	32800543	Crystal structure of the SPRY domain-containing protein 7 (SPRY7)	2020-06-16	2020-10-14	Yang, J.,Guan, X.,Zhang, D.,Zhao, P.,Guo, S.,Kuang, Z.	Crystal structure of the SPRY domain-containing protein 7 reveals unique structural features.	Biochem.Biophys.Res.Commun.	2020	531	350	356	
7CI1		Crystal structure of AcrVA2	2020-07-07	2020-10-14	Chen, P.,Sun, W.,Cheng, Z.,Yang, J.,Wang, M.,Wang, J.,Chen, H.,Liu, L.,Wang, Y.	Structural Study on Anti-CRISPR Protein AcrVA2	Prog.Biochem.Biophys.	2021	0	0	0	
7CI2		Crystal structure of AcrVA2 in complex with partial MbCpf1	2020-07-07	2020-10-14	Chen, P.,Sun, W.,Cheng, Z.,Yang, J.,Wang, M.,Wang, J.,Chen, H.,Liu, L.,Wang, Y.	Structural Study on Anti-CRISPR Protein AcrVA2	Prog.Biochem.Biophys.	2021	0	0	0	
7CU5	33063473	N-Glycosylation of PD-1 and glycosylation dependent binding of PD-1 specific monoclonal antibody camrelizumab	2020-08-21	2020-10-14	Liu, K.,Tan, S.,Jin, W.,Guan, J.,Wang, Q.,Sun, H.,Qi, J.,Yan, J.,Chai, Y.,Wang, Z.,Deng, C.,Gao, G.F.	N-glycosylation of PD-1 promotes binding of camrelizumab.	Embo Rep.	2020	21	0	0	
7C5D	33203878	Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide	2020-05-19	2020-10-21	Cicconi, A.,Rai, R.,Xiong, X.,Broton, C.,Al-Hiyasat, A.,Hu, C.,Dong, S.,Sun, W.,Garbarino, J.,Bindra, R.S.,Schildkraut, C.,Chen, Y.,Chang, S.	Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly.	Nat Commun	2020	11	5861	5861	
7CZE	33235207	Crystal structure of Epstein-Barr virus (EBV) gHgL and in complex with the ligand binding domian (LBD) of EphA2	2020-09-08	2020-10-21	Su, C.,Wu, L.,Chai, Y.,Qi, J.,Tan, S.,Gao, G.F.,Song, H.,Yan, J.	Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses.	Nat Commun	2020	11	5964	5964	
6LE2		Structure of D-carbamoylase mutant from Nitratireductor indicus	2019-11-23	2020-10-28	Liu, Y.,Xu, G.,Zhou, J.,Ni, J.,Zhang, L.,Hou, X.,Yin, D.,Rao, Y.,Zhao, Y.L.,Ni, Y.	Structure-Guided Engineering of D-Carbamoylase Reveals a Key Loop at Substrate Entrance Tunnel	Acs Catalysis	2020	10	12393	12402	
6LED		Structure of D-carbamoylase mutant from Nitratireductor indicus	2019-11-25	2020-10-28	Liu, Y.,Xu, G.,Zhou, J.,Ni, J.,Zhang, L.,Hou, X.,Yin, D.,Rao, Y.,Zhao, Y.L.,Ni, Y.	Structure-Guided Engineering of D-Carbamoylase Reveals a Key Loop at Substrate Entrance Tunnel	Acs Catalysis	2020	10	12393	12402	
6LJM	32163813	Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P13	2019-12-17	2020-10-28	Yang, L.L.,Wang, H.L.,Yan, Y.H.,Liu, S.,Yu, Z.J.,Huang, M.Y.,Luo, Y.,Zheng, X.,Yu, Y.,Li, G.B.	Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.	Eur.J.Med.Chem.	2020	192	112201	112201	
6LJN	32163813	Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P15	2019-12-17	2020-10-28	Yang, L.L.,Wang, H.L.,Yan, Y.H.,Liu, S.,Yu, Z.J.,Huang, M.Y.,Luo, Y.,Zheng, X.,Yu, Y.,Li, G.B.	Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.	Eur.J.Med.Chem.	2020	192	112201	112201	
6LTP	33067443	Crystal structure of Cas12i2 binary complex	2020-01-23	2020-10-28	Huang, X.,Sun, W.,Cheng, Z.,Chen, M.,Li, X.,Wang, J.,Sheng, G.,Gong, W.,Wang, Y.	Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.	Nat Commun	2020	11	5241	5241	
7CLA	33454020	Crystal structure of HTH-type transcriptional regulator SkgA from Caulobacter crescentus	2020-07-20	2020-10-28	Jiang, X.,Zhang, L.,Teng, M.,Li, X.	Antibiotic binding releases autoinhibition of the TipA multidrug-resistance transcriptional regulator.	J.Biol.Chem.	2020	295	17865	17876	
7CNC	33035348	cystal structure of human ERH in complex with DGCR8	2020-07-30	2020-10-28	Kwon, S.C.,Jang, H.,Shen, S.,Baek, S.C.,Kim, K.,Yang, J.,Kim, J.,Kim, J.S.,Wang, S.,Shi, Y.,Li, F.,Kim, V.N.	ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8.	Nucleic Acids Res.	2020	48	11097	11112	
7CP2		Crystal structure of the African swine fever virus core shell protein p15	2020-08-05	2020-10-28	Liu, K.F.,Meng, Y.M.,Chai, Y.,Li, L.J.,Sun, H.,Gao, G.F.,Tan, S.G.,Qi, J.X.	Crystal structure of the African swine fever virus core shell protein p15	Biosaf Health	2021	0	0	0	
7CYZ	32819557	The structure of human ORP3 OSBP-related domain	2020-09-05	2020-10-28	Dong, X.,Wang, Z.,Ye, S.,Zhang, R.	The crystal structure of ORP3 reveals the conservative PI4P binding pattern.	Biochem.Biophys.Res.Commun.	2020	529	1005	1010	
6L6P		hASIC2a co-crystallized with Mamb-1	2019-10-29	2020-11-04	Lei, F.,Jian, S.	hASIC2a co-crystallized with Mamb-1	To Be Published	0	0	0	0	
6L6S	33248387	The structure of the UdgX mutant H109E crosslinked to single-stranded DNA	2019-10-29	2020-11-04	Jia, Q.,Zeng, H.,Tu, J.,Sun, L.,Cao, W.,Xie, W.	Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability.	DNA Repair (Amst)	2021	97	103008	103008	
6LBE	32438322	Crystal structure of bony fish MHC class I binding beta2M-2 for 2.6 angstrom	2019-11-14	2020-11-04	Li, Z.,Zhang, N.,Ma, L.,Zhang, L.,Meng, G.,Xia, C.	The Mechanism of beta 2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish.	Iscience	2020	23	101119	101119	
6LG3	33097533	Crystal structure of a bacterial toxin from Mycobacterium tuberculosis	2019-12-04	2020-11-04	Qu, Z.,Zhou, J.,Zhou, Y.,Xie, Y.,Jiang, Y.,Wu, J.,Luo, Z.,Liu, G.,Yin, L.,Zhang, X.L.	Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1 beta immune pathway.	Sci Adv	2020	6	0	0	
7D6F	34371146	The crystal structure of ARMS-PBM/MAGI2-PDZ4	2020-09-30	2020-11-04	Zhang, Y.,Zhong, Z.,Ye, J.,Wang, C.	Crystal structure of the PDZ4 domain of MAGI2 in complex with PBM of ARMS reveals a canonical PDZ recognition mode.	Neurochem.Int.	2021	149	105152	105152	
7DBW	34469195	PnpA1, the oxygenase component of a two-component para-nitrophenol hydroxylase from Rhodococcus imtechensis RKJ300	2020-10-22	2020-11-04	Guo, Y.,Li, D.F.,Zheng, J.,Xu, Y.,Zhou, N.Y.	Single-Component and Two-Component para -Nitrophenol Monooxygenases: Structural Basis for Their Catalytic Difference.	Appl.Environ.Microbiol.	2021	87	0	0	
6L8G		High resolution structure of YoeB in complex with YefM C-terminus(46N-83V) from Staphylococcus aureus.	2019-11-06	2020-11-11	Xue, L.,Yue, J.	Structural insight into the mechanism of conditional cooperativity in the YoeB-YefM toxin-antitoxin system	To Be Published	0	0	0	0	
6L9J	32284172	Structure of yeast Snf5 and Swi3 subcomplex	2019-11-10	2020-11-11	Zhou, H.,Chen, G.,Dong, C.,Zhao, X.,Shen, Z.,Chen, F.,Liu, B.,Long, J.	Snf5 and Swi3 subcomplex formation is required for SWI/SNF complex function in yeast.	Biochem.Biophys.Res.Commun.	2020	526	934	940	
6L9O		Crystal structure of FABP7 apo	2019-11-10	2020-11-11	Wei, P.C.,Zhao, K.,Yin, L.	Crystal structure of FABP7 apo	To Be Published	0	0	0	0	
6LIS	33139328	ASFV dUTPase in complex with dUMP	2019-12-12	2020-11-11	Liang, R.,Wang, G.,Zhang, D.,Ye, G.,Li, M.,Shi, Y.,Shi, J.,Chen, H.,Peng, G.	Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development.	J.Biol.Chem.	2020	296	100015	100015	
6LJ3	33139328	full length ASFV dUTPase in complex with alpha,beta-iminodUTP and magnesium ion	2019-12-13	2020-11-11	Liang, R.,Wang, G.,Zhang, D.,Ye, G.,Li, M.,Shi, Y.,Shi, J.,Chen, H.,Peng, G.	Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development.	J.Biol.Chem.	2020	296	100015	100015	
6L9L	34074778	1D4 TCR recognition of H2-Ld a1a2 A5 Peptide Complexes	2019-11-10	2020-11-18	Wei, P.,Jordan, K.R.,Buhrman, J.D.,Lei, J.,Deng, H.,Marrack, P.,Dai, S.,Kappler, J.W.,Slansky, J.E.,Yin, L.	Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
6LFN	33199630	Crystal structure of LpCGTb	2019-12-03	2020-11-18	Wang, Z.L.,Gao, H.M.,Wang, S.,Zhang, M.,Chen, K.,Zhang, Y.Q.,Wang, H.D.,Han, B.Y.,Xu, L.L.,Song, T.Q.,Yun, C.H.,Qiao, X.,Ye, M.	Dissection of the general two-step di- C -glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants.	Proc.Natl.Acad.Sci.USA	2020	117	30816	30823	
6LG0	33199630	Crystal structure of SbCGTa in complex with UDP	2019-12-04	2020-11-18	Wang, Z.L.,Gao, H.M.,Wang, S.,Zhang, M.,Chen, K.,Zhang, Y.Q.,Wang, H.D.,Han, B.Y.,Xu, L.L.,Song, T.Q.,Yun, C.H.,Qiao, X.,Ye, M.	Dissection of the general two-step di- C -glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants.	Proc.Natl.Acad.Sci.USA	2020	117	30816	30823	
7BV5	33272269	Crystal structure of the yeast heterodimeric ADAT2/3	2020-04-09	2020-11-18	Liu, X.,Chen, R.,Sun, Y.,Chen, R.,Zhou, J.,Tian, Q.,Tao, X.,Zhang, Z.,Luo, G.Z.,Xie, W.	Crystal structure of the yeast heterodimeric ADAT2/3 deaminase.	Bmc Biol.	2020	18	189	189	
6LE0	32832808	A nonspecific heme-binding cyclase catalyzes [4 + 2] cycloaddition during neoabyssomicin biosynthesis	2019-11-23	2020-11-25	Li, Q.,Ding, W.,Tu, J.,Chi, C.,Huang, H.,Ji, X.,Yao, Z.,Ma, M.,Ju, J.	Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes [4 + 2] Cycloaddition during Neoabyssomicin Biosynthesis.	Acs Omega	2020	5	20548	20557	
6LQ8	32601219	Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C22CoA	2020-01-13	2020-11-25	Chen, X.B.,Chen, J.,Yan, B.,Zhang, W.,Guddat, L.W.,Liu, X.,Rao, Z.	Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.	Proc.Natl.Acad.Sci.USA	2020	117	16324	16332	
7C1H	33436600	Crystal structure of the starter condensation domain of rhizomide synthetase RzmA	2020-05-04	2020-11-25	Zhong, L.,Diao, X.,Zhang, N.,Li, F.,Zhou, H.,Chen, H.,Bai, X.,Ren, X.,Zhang, Y.,Wu, D.,Bian, X.	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.	Nat Commun	2021	12	296	296	
7C1K	33436600	Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant R148A	2020-05-04	2020-11-25	Zhong, L.,Diao, X.,Zhang, N.,Li, F.,Zhou, H.,Chen, H.,Bai, X.,Ren, X.,Zhang, Y.,Wu, D.,Bian, X.	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.	Nat Commun	2021	12	296	296	
7C1P	33436600	Crystal structure of the starter condensation domain of the rhizomide synthetase RzmA mutant H140V, R148A	2020-05-05	2020-11-25	Zhong, L.,Diao, X.,Zhang, N.,Li, F.,Zhou, H.,Chen, H.,Bai, X.,Ren, X.,Zhang, Y.,Wu, D.,Bian, X.	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.	Nat Commun	2021	12	296	296	
7C1R	33436600	Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant H140A/R148A in complex with C8-CoA	2020-05-05	2020-11-25	Zhong, L.,Diao, X.,Zhang, N.,Li, F.,Zhou, H.,Chen, H.,Bai, X.,Ren, X.,Zhang, Y.,Wu, D.,Bian, X.	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.	Nat Commun	2021	12	296	296	
7C1S	33436600	Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant H140A/R148A in complex with C8-CoA and Leu-SNAC	2020-05-05	2020-11-25	Zhong, L.,Diao, X.,Zhang, N.,Li, F.,Zhou, H.,Chen, H.,Bai, X.,Ren, X.,Zhang, Y.,Wu, D.,Bian, X.	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.	Nat Commun	2021	12	296	296	
7C1U	33436600	Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant H140V/R148A in a ""product-released"" conformation	2020-05-05	2020-11-25	Zhong, L.,Diao, X.,Zhang, N.,Li, F.,Zhou, H.,Chen, H.,Bai, X.,Ren, X.,Zhang, Y.,Wu, D.,Bian, X.	Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.	Nat Commun	2021	12	296	296	
7D7Z	33170270	Crystal Structure of the Domain1 of NAD+ Riboswitch with nicotinamide adenine dinucleotide (NAD+), soaked in Mn2+	2020-10-06	2020-11-25	Chen, H.,Egger, M.,Xu, X.,Flemmich, L.,Krasheninina, O.,Sun, A.,Micura, R.,Ren, A.	Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding.	Nucleic Acids Res.	2020	48	12394	12406	
7D81	33170270	Crystal Structure of the Domain2 of NAD+ Riboswitch with nicotinamide adenine dinucleotide (NAD+)	2020-10-06	2020-11-25	Chen, H.,Egger, M.,Xu, X.,Flemmich, L.,Krasheninina, O.,Sun, A.,Micura, R.,Ren, A.	Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding.	Nucleic Acids Res.	2020	48	12394	12406	
7D82	33170270	Crystal Structure of the Domain2 of NAD+ Riboswitch with nicotinamide adenine dinucleotide (NAD+), soaked in Mn2+	2020-10-06	2020-11-25	Chen, H.,Egger, M.,Xu, X.,Flemmich, L.,Krasheninina, O.,Sun, A.,Micura, R.,Ren, A.	Structural distinctions between NAD+ riboswitch domains 1 and 2 determine differential folding and ligand binding.	Nucleic Acids Res.	2020	48	12394	12406	
6LKG	33199635	two-component system protein mediate signal transduction	2019-12-19	2020-12-02	Wang, M.,Guo, Q.,Zhu, K.,Fang, B.,Yang, Y.,Teng, M.,Li, X.,Tao, Y.	Interface switch mediates signal transmission in a two-component system.	Proc.Natl.Acad.Sci.USA	2020	117	30433	30440	
6LKI	33199635	Two-component system protein mediate signal transduction	2019-12-19	2020-12-02	Wang, M.,Guo, Q.,Zhu, K.,Fang, B.,Yang, Y.,Teng, M.,Li, X.,Tao, Y.	Interface switch mediates signal transmission in a two-component system.	Proc.Natl.Acad.Sci.USA	2020	117	30433	30440	
6LKJ	33199635	Two-component system protein mediate signal transduction	2019-12-19	2020-12-02	Wang, M.,Guo, Q.,Zhu, K.,Fang, B.,Yang, Y.,Teng, M.,Li, X.,Tao, Y.	Interface switch mediates signal transmission in a two-component system.	Proc.Natl.Acad.Sci.USA	2020	117	30433	30440	
6LKK	33199635	Two-component system protein mediate signal transduction	2019-12-19	2020-12-02	Wang, M.,Guo, Q.,Zhu, K.,Fang, B.,Yang, Y.,Teng, M.,Li, X.,Tao, Y.	Interface switch mediates signal transmission in a two-component system.	Proc.Natl.Acad.Sci.USA	2020	117	30433	30440	
6LKL	33199635	Two-component system protein mediate signal transduction	2019-12-19	2020-12-02	Wang, M.,Guo, Q.,Zhu, K.,Fang, B.,Yang, Y.,Teng, M.,Li, X.,Tao, Y.	Interface switch mediates signal transmission in a two-component system.	Proc.Natl.Acad.Sci.USA	2020	117	30433	30440	
6LUS	32093889	Crystal structure of the Mengla Virus VP30 C-terminal domain	2020-01-30	2020-12-02	Dong, S.,Wen, K.,Chu, H.,Li, H.,Yu, Q.,Wang, C.,Qin, X.	Crystal structure of the Mengla virus VP30 C-terminal domain.	Biochem.Biophys.Res.Commun.	2020	525	392	397	
7C6O	33210347	Catalytic Subunit of Cobaltochelatase from Mycobacterium tuberculosis	2020-05-22	2020-12-02	Zhang, J.H.,Yuan, H.,Wang, X.,Dai, H.E.,Zhang, M.,Liu, L.	Crystal structure of the large subunit of cobaltochelatase from Mycobacterium tuberculosis.	Proteins	2021	89	462	467	
6LG4		crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-1024	2019-12-04	2020-12-09	Xu, H.,Zuo, Y.,Zhang, H.	Lead-Opt: An efficient tool for structural optimization of lead compounds	To Be Published	0	0	0	0	
6LG5		Crystal Structure of the first bromodomain of human BRD4 in complex with compound BDF-1038	2019-12-04	2020-12-09	Xu, H.,Zuo, Y.	Lead-Opt: An efficient tool for structural optimization of lead compounds	To Be Published	0	0	0	0	
6LG6		Crystal Structure of the first bromodomain of human BRD4 in complex with compound BDF-1021	2019-12-04	2020-12-09	Xu, H.,Zuo, Y.	Lead-Opt: An efficient tool for structural optimization of lead compounds	To Be Published	0	0	0	0	
6LG7		Crystal Structure of the first bromodomain of human BRD4 in complex with compound BDF-2030	2019-12-04	2020-12-09	Xu, H.,Zuo, Y.	Lead-Opt: An efficient tool for structural optimization of lead compounds	To Be Published	0	0	0	0	
6LG8		crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2138	2019-12-04	2020-12-09	Xu, H.,Zuo, Y.,Zhang, H.,Luo, C.	Lead-Opt: An efficient tool for structural optimization of lead compounds	To Be Published	0	0	0	0	
6LG9		crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2143	2019-12-04	2020-12-09	Xu, H.,Zuo, Y.,Luo, C.,Zhang, H.	Lead-Opt: An efficient tool for structural optimization of lead compounds	To Be Published	0	0	0	0	
6LGJ		Crystal structure of an oxido-reductase	2019-12-05	2020-12-09	Yang, Y.,Lei, J.,Yin, L.	Crystal structure of an oxido-reductase	To be published	0	0	0	0	
6LGK		Crystal structure of an oxido-reductase with mutation	2019-12-05	2020-12-09	Yang, Y.,Lei, J.,Yin, L.	Crystal structure of an oxido-reductase with mutation	To Be Published	0	0	0	0	
6LGM		Crystal structure of an oxido-reductase with mutation and inhibitor	2019-12-05	2020-12-09	Yang, Y.,Lei, J.,Yin, L.	Crystal structure of an oxido-reductase with mutation and inhibitor	To Be Published	0	0	0	0	
6LH1	33404530	Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter trapped in an outward-facing conformation	2019-12-06	2020-12-09	Wang, X.,Lyu, Y.,Ji, Y.,Sun, Z.,Zhou, X.	An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.	Acta Crystallogr D Struct Biol	2021	77	108	116	
6LH4	32683309	Crystal structural of MacroD1-ADPr complex	2019-12-06	2020-12-09	Yang, X.,Ma, Y.,Li, Y.,Dong, Y.,Yu, L.L.,Wang, H.,Guo, L.,Wu, C.,Yu, X.,Liu, X.	Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation.	DNA Repair (Amst)	2020	94	102899	102899	
6XY2	33298884	Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody	2020-01-29	2020-12-09	Gao, H.,Cai, H.,Liu, J.,Wang, X.,Zheng, P.,Devenport, M.,Xu, T.,Dou, F.,Liu, Y.,Zhou, A.	Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody.	Cell Discov	2020	6	79	79	
7BZJ	33221064	The Discovery of Benzhydrol-Oxaborole Hybrid Derivatives as Leucyl-tRNA Synthetase Inhibitors	2020-04-28	2020-12-09	Hao, G.,Li, H.,Yang, F.,Dong, D.,Li, Z.,Ding, Y.,Pan, W.,Wang, E.,Liu, R.,Zhou, H.	Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors.	Bioorg.Med.Chem.	2021	29	115871	115871	
6LIG		Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) in complex with AH	2019-12-10	2020-12-16	Shan, Y.	Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) in complex with AH	To Be Published	0	0	0	0	
6LIJ		Crassostrea gigas ferritin	2019-12-11	2020-12-16	Li, H.,Zang, J.,Tan, X.,Wang, Z.,Du, M.	Crassostrea gigas ferritin	To Be Published	0	0	0	0	
6LIZ	33302045	Crystal structure of NDM-1 in complex with D-captopril derivative wss02120	2019-12-13	2020-12-16	Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H.	Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.	Bioorg.Med.Chem.	2020	29	115902	115902	
6LJ0	33302045	Crystal structure of NDM-1 in complex with D-captopril derivative wss02122	2019-12-13	2020-12-16	Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H.	Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.	Bioorg.Med.Chem.	2020	29	115902	115902	
6LJ4	33302045	Crystal structure of NDM-1 in complex with D-captopril derivative wss04146	2019-12-13	2020-12-16	Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H.	Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.	Bioorg.Med.Chem.	2020	29	115902	115902	
6LJ5	33302045	Crystal structure of NDM-1 in complex with D-captopril derivative wss04145	2019-12-13	2020-12-16	Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H.	Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.	Bioorg.Med.Chem.	2020	29	115902	115902	
6LJ7	33302045	Crystal structure of NDM-1 in complex with D-captopril derivative wss05010	2019-12-13	2020-12-16	Ma, G.,Wang, S.,Wu, K.,Zhang, W.,Ahmad, A.,Hao, Q.,Lei, X.,Zhang, H.	Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.	Bioorg.Med.Chem.	2020	29	115902	115902	
7BYJ	33216857	Crystal structure of the FERM domain of FRMPD4	2020-04-23	2020-12-16	Wang, M.,Lin, L.,Shi, Y.,He, L.,Wang, C.,Zhu, J.	Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability.	Biochem.J.	2020	477	4623	4634	
7CCE	33277495	crystal structure of Arabidopsis AIPP3 BAH domain in complex with an H3K27me3 peptide	2020-06-17	2020-12-16	Zhang, Y.Z.,Yuan, J.,Zhang, L.,Chen, C.,Wang, Y.,Zhang, G.,Peng, L.,Xie, S.S.,Jiang, J.,Zhu, J.K.,Du, J.,Duan, C.G.	Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis.	Nat Commun	2020	11	6212	6212	
7CN3		2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid	2020-07-30	2020-12-16	Liu, G.Q.,Tang, H.Z.	2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid	Nat Commun	2020	0	0	0	
7CUP		Structure of 2,5-dihydroxypridine Dioxygenase from Pseudomonas putida KT2440	2020-08-23	2020-12-16	Liu, G.Q.,Tang, H.Z.	2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid	Nat Commun	2020	0	0	0	
6LJK	32163813	Crystal structure of human Sirt5 in complex with an internally quenched fluorescent substrate GluIQF	2019-12-17	2020-12-23	Yang, L.L.,Wang, H.L.,Yan, Y.H.,Liu, S.,Yu, Z.J.,Huang, M.Y.,Luo, Y.,Zheng, X.,Yu, Y.,Li, G.B.	Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.	Eur.J.Med.Chem.	2020	192	112201	112201	
6LK6	34158471	MLKL mutant - T357AS358A	2019-12-18	2020-12-23	Zhang, Y.,Liu, J.,Yu, D.,Zhu, X.,Liu, X.,Liao, J.,Li, S.,Wang, H.	The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.	Cell Death Dis	2021	12	638	638	
6LZ2	33303987	Crystal structure of a thermostable green fluorescent protein (TGP) with a synthetic nanobody (Sb44)	2020-02-17	2020-12-23	Cai, H.,Yao, H.,Li, T.,Hutter, C.A.J.,Li, Y.,Tang, Y.,Seeger, M.A.,Li, D.	An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification.	Commun Biol	2020	3	753	753	
6VBK	31306520	Crystal structure of N-terminal domain of Mycobacterium tuberculosis complex Lon protease	2019-12-19	2020-12-23	Chen, X.,Zhang, S.,Bi, F.,Guo, C.,Feng, L.,Wang, H.,Yao, H.,Lin, D.	Crystal structure of the N domain of Lon protease from Mycobacterium avium complex.	Protein Sci.	2019	28	1720	1726	
6LNK		Candida albicans Fructose-1,6-bisphosphate aldolase	2019-12-30	2020-12-30	Wen, W.,Cao, H.,Huang, Y.,Tu, J.,Wan, C.,Wan, J.,Han, X.,Chen, H.,Liu, J.,Rao, L.,Su, C.,Peng, C.,Sheng, C.,Ren, Y.	Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.	J.Med.Chem.	2022	65	2656	2674	
6M06	32459096	Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor	2020-02-20	2020-12-30	Huang, F.,Hu, H.,Wang, K.,Peng, C.,Xu, W.,Zhang, Y.,Gao, J.,Liu, Y.,Zhou, H.,Huang, R.,Li, M.,Shen, J.,Xu, Y.	Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach.	J.Med.Chem.	2020	63	7052	7065	
6M08	32459096	Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor.	2020-02-20	2020-12-30	Huang, F.,Hu, H.,Wang, K.,Peng, C.,Xu, W.,Zhang, Y.,Gao, J.,Liu, Y.,Zhou, H.,Huang, R.,Li, M.,Shen, J.,Xu, Y.	Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach.	J.Med.Chem.	2020	63	7052	7065	
7AER	33290744	Rebuilt and re-refined PDB entry 5yep: tri-AMPylated Shewanella oneidensis HEPN toxin in complex with MNT antitoxin	2020-09-18	2020-12-30	Songailiene, I.,Juozapaitis, J.,Tamulaitiene, G.,Ruksenaite, A.,Sulcius, S.,Sasnauskas, G.,Venclovas, C.,Siksnys, V.	HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation.	Mol.Cell	2020	80	955	0	
7CY4	33531488	Crystal Structure of CMD1 in apo form	2020-09-03	2020-12-30	Li, W.,Zhang, T.,Sun, M.,Shi, Y.,Zhang, X.J.,Xu, G.L.,Ding, J.	Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1.	Nat Commun	2021	12	744	744	
7CY5	33531488	Crystal Structure of CMD1 in complex with vitamin C	2020-09-03	2020-12-30	Li, W.,Zhang, T.,Sun, M.,Shi, Y.,Zhang, X.J.,Xu, G.L.,Ding, J.	Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1.	Nat Commun	2021	12	744	744	
6LOA		Crystal structure of RORgammat with ligand C46D bound	2020-01-04	2021-01-06	Feng, Y.,Shijie, C.	Crystal structure of RORgammat with ligand C46D bound	To Be Published	0	0	0	0	
6LYQ	33368572	Structure of the BAM complex	2020-02-15	2021-01-06	Xiao, L.,Han, L.,Li, B.,Zhang, M.,Zhou, H.,Luo, Q.,Zhang, X.,Huang, Y.	Structures of the beta-barrel assembly machine recognizing outer membrane protein substrates.	Faseb J.	2021	35	0	0	
6L02		Crystal Structure of sfYFP66BPAC203Y	2019-09-25	2021-01-13	Zheng, D.,Tao, M.,Yu, L.J.,Liu, X.,Xia, A.,Wang, J.	Ultrafast Photoinduced Electron Transfer in a Photosensitizer Protein	CCS Chem	2021	3	1580	1586	
6LOX	33792311	Crystal Structure of human glutaminase with macrocyclic inhibitor	2020-01-07	2021-01-13	Xu, X.,Wang, J.,Wang, M.,Yuan, X.,Li, L.,Zhang, C.,Huang, H.,Jing, T.,Wang, C.,Tong, C.,Zhou, L.,Meng, Y.,Xu, P.,Kou, J.,Qiu, Z.,Li, Z.,Bian, J.	Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site.	J.Med.Chem.	2021	64	4588	4611	
6LPN	33431826	Crystal structure of human D-2-hydroxyglutarate dehydrogenase in apo form	2020-01-12	2021-01-13	Yang, J.,Zhu, H.,Zhang, T.,Ding, J.	Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.	Cell Discov	2021	7	3	3	
6LPP	33431826	Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-2-hydroxyglutarate (D-2-HG)	2020-01-12	2021-01-13	Yang, J.,Zhu, H.,Zhang, T.,Ding, J.	Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.	Cell Discov	2021	7	3	3	
6LPQ	33431826	Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-malate (D-MAL)	2020-01-12	2021-01-13	Yang, J.,Zhu, H.,Zhang, T.,Ding, J.	Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.	Cell Discov	2021	7	3	3	
6LPT	33431826	Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-lactate (D-LAC)	2020-01-12	2021-01-13	Yang, J.,Zhu, H.,Zhang, T.,Ding, J.	Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.	Cell Discov	2021	7	3	3	
6LPV	33519864	structure of Spermidine hydroxycinnamoyl transferases from Arabidopsis thaliana	2020-01-12	2021-01-13	Wang, C.,Li, J.,Ma, M.,Lin, Z.,Hu, W.,Lin, W.,Zhang, P.	Structural and Biochemical Insights Into Two BAHD Acyltransferases ( At SHT and At SDT) Involved in Phenolamide Biosynthesis.	Front Plant Sci	2020	11	610118	610118	
6LPX	33431826	Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-OG)	2020-01-12	2021-01-13	Yang, J.,Zhu, H.,Zhang, T.,Ding, J.	Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.	Cell Discov	2021	7	3	3	
6LQB		A third intermediate state of L,D-transpeptidase LdtMt2-ertapenem adduct	2020-01-13	2021-01-13	Wang, X.Y.,Qin, Y.L.,Han, Q.,Gu, X.E.,Yan, Z.,Fu, K.,Li, D.F.,Deng, K.	A New State I-plus Observed for the L,D-transpeptidase LdtMt2-ertapenem Adduct	Prog.Biochem.Biophys.	2020	47	989	997	
6S3E	33784404	Crystal structure of helicase Pif1 from Thermus oshimai in apo form	2019-06-25	2021-01-13	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
6S3H	33784404	Crystal structure of helicase Pif1 from Thermus oshimai in complex with ADP-AlF4 and (dT)7ds11bp	2019-06-25	2021-01-13	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
6S3I	33784404	Crystal structure of helicase Pif1 from Thermus oshimai in complex with ssDNA (dT)18 and ADP-MgF4	2019-06-25	2021-01-13	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
6S3M	33784404	Crystal structure of helicase Pif1 from Thermus oshimai in complex with ssDNA (dT)18 and ADP-AlF4	2019-06-25	2021-01-13	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
6S3N	33784404	Crystal structure of helicase Pif1 from Thermus oshimai in complex with ssDNA (dT)18 and ADP-VO4	2019-06-25	2021-01-13	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
6S3O	33784404	Crystal structure of helicase Pif1 from Thermus oshimai in complex with ssDNA (dT)18 and ADP	2019-06-25	2021-01-13	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
6S3P	33784404	Crystal structure of helicase Pif1 from Thermus oshimai in complex with (dT)18	2019-06-25	2021-01-13	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
7CSY	33346387	Pseudomonas aeruginosa antitoxin HigA with higBA promoter	2020-08-17	2021-01-13	Song, Y.,Luo, G.,Zhu, Y.,Li, T.,Li, C.,He, L.,Zhao, N.,Zhao, C.,Yang, J.,Huang, Q.,Mu, X.,Tang, X.,Kang, M.,Wu, S.,He, Y.,Bao, R.	Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs.	Environ.Microbiol.	2021	23	1541	1558	
7CYG	33404530	Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter before disulfide bond formation	2020-09-03	2021-01-13	Wang, X.,Lyu, Y.,Ji, Y.,Sun, Z.,Zhou, X.	An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.	Acta Crystallogr D Struct Biol	2021	77	108	116	
7CYK	33404530	Crystal structure of a second cysteine-pair mutant (V110C-I197C) of a bacterial bile acid transporter before disulfide bond formation	2020-09-03	2021-01-13	Wang, X.,Lyu, Y.,Ji, Y.,Sun, Z.,Zhou, X.	An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.	Acta Crystallogr D Struct Biol	2021	77	108	116	
7DAW	33397709	Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase	2020-10-18	2021-01-13	Wang, H.,Xu, M.,Engelhart, C.A.,Zhang, X.,Yan, B.,Pan, M.,Xu, Y.,Fan, S.,Liu, R.,Xu, L.,Hua, L.,Schnappinger, D.,Chen, S.	Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .	J.Biol.Chem.	2021	0	0	0	
7DB7	33397709	Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001	2020-10-19	2021-01-13	Wang, H.,Xu, M.,Engelhart, C.A.,Zhang, X.,Yan, B.,Pan, M.,Xu, Y.,Fan, S.,Liu, R.,Xu, L.,Hua, L.,Schnappinger, D.,Chen, S.	Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .	J.Biol.Chem.	2021	0	0	0	
7DB8	33397709	Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845	2020-10-19	2021-01-13	Wang, H.,Xu, M.,Engelhart, C.A.,Zhang, X.,Yan, B.,Pan, M.,Xu, Y.,Fan, S.,Liu, R.,Xu, L.,Hua, L.,Schnappinger, D.,Chen, S.	Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .	J.Biol.Chem.	2021	0	0	0	
6LQX		Crystal structure of the CBP bromodomain in complex with small molecule LC-CPin7	2020-01-14	2021-01-20	Chen, Y.,Bi, X.,Zhang, F.,Sun, Z.,Luo, C.	Design, synthesis and biological evaluation of novel small molecule inhibitor of the CBP bromodomain with possible anti-leukemia effects	To Be Published	0	0	0	0	
7DHD	33450227	Vibrio vulnificus Wzb	2020-11-14	2021-01-20	Wang, X.,Ma, Q.	Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop.	J.Biol.Chem.	2021	296	100280	100280	
7DHE	33450227	Vibrio vulnificus Wzb in complex with benzylphosphonate	2020-11-14	2021-01-20	Wang, X.,Ma, Q.	Wzb of Vibrio vulnificus represents a new group of low-molecular-weight protein tyrosine phosphatases with a unique insertion in the W-loop.	J.Biol.Chem.	2021	296	100280	100280	
6LT7	33571640	Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP	2020-01-21	2021-01-27	Yin, C.,Bai, G.,Zhang, Y.,Huang, J.	Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP.	J.Struct.Biol.	2021	213	107704	107704	
6M7A		Structure of REV7-R124A complexed with SHLD3(28-73)	2020-03-18	2021-01-27	Ma, Y.Z.,Li, Y.,Wu, B.X.,Huang, H.D.	Structure of REV7-R124A complexed with SHLD3(28-73)	To Be Published	0	0	0	0	
6M7B		Structure of REV7-R124A complexed with SHLD3(37-73)	2020-03-18	2021-01-27	Ma, Y.Z.,Li, Y.,Wu, B.X.,Huang, H.D.	Structure of REV7-R124A complexed with SHLD3(37-73)	To Be Published	0	0	0	0	
7C8J	33335073	Structural basis for cross-species recognition of COVID-19 virus spike receptor binding domain to bat ACE2	2020-06-01	2021-01-27	Liu, K.,Tan, S.,Niu, S.,Wang, J.,Wu, L.,Sun, H.,Zhang, Y.,Pan, X.,Qu, X.,Du, P.,Meng, Y.,Jia, Y.,Chen, Q.,Deng, C.,Yan, J.,Wang, H.W.,Wang, Q.,Qi, J.,Gao, G.F.	Cross-species recognition of SARS-CoV-2 to bat ACE2.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7D79	33351624	The structure of DcsB complex with its substrate analogue	2020-10-03	2021-01-27	Gao, D.W.,Jamieson, C.S.,Wang, G.,Yan, Y.,Zhou, J.,Houk, K.N.,Tang, Y.	A Polyketide Cyclase That Forms Medium-Ring Lactones.	J.Am.Chem.Soc.	2021	143	80	84	
7D79	33351624	The structure of DcsB complex with its substrate analogue	2020-10-03	2021-01-27	Gao, D.W.,Jamieson, C.S.,Wang, G.,Yan, Y.,Zhou, J.,Houk, K.N.,Tang, Y.	A Polyketide Cyclase That Forms Medium-Ring Lactones.	J.Am.Chem.Soc.	2021	143	80	84	
6LPE	33448656	Phascolosoma esculenta ferritin	2020-01-10	2021-02-03	Ming, T.,Huan, H.,Su, C.,Huo, C.,Wu, Y.,Jiang, Q.,Qiu, X.,Lu, C.,Zhou, J.,Li, Y.,Su, X.	Structural comparison of two ferritins from the marine invertebrate Phascolosoma esculenta.	Febs Open Bio	2021	11	793	803	
6LUI	33980486	Crystal structure of the SAMD1 WH domain and DNA complex	2020-01-29	2021-02-03	Stielow, B.,Zhou, Y.,Cao, Y.,Simon, C.,Pogoda, H.M.,Jiang, J.,Ren, Y.,Phanor, S.K.,Rohner, I.,Nist, A.,Stiewe, T.,Hammerschmidt, M.,Shi, Y.,Bulyk, M.L.,Wang, Z.,Liefke, R.	The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.	Sci Adv	2021	7	0	0	
6LUK	33980486	Crystal structure of the SAMD1 SAM domain in another crystal form	2020-01-29	2021-02-03	Stielow, B.,Zhou, Y.,Cao, Y.,Simon, C.,Pogoda, H.M.,Jiang, J.,Ren, Y.,Phanor, S.K.,Rohner, I.,Nist, A.,Stiewe, T.,Hammerschmidt, M.,Shi, Y.,Bulyk, M.L.,Wang, Z.,Liefke, R.	The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.	Sci Adv	2021	7	0	0	
6M31		Structural and Functional Insights into an Archaeal Lipid Synthase	2020-03-02	2021-02-03	Ren, S.,de Kok, N.A.,Gu, Y.,Yan, W.,Sun, Q.,Chen, Y.,He, J.,Tian, L.,Andringa, R.L.,Zhu, X.,Tang, M.,Qi, S.,Xu, H.,Ren, H.,Fu, X.,Minnaard, A.J.,Yang, S.,Zhang, W.,Li, W.,Wei, Y.,Driessen, A.J.,Cheng, W.	Structural and Functional Insights into an Archaeal Lipid Synthase	Cell Rep	2020	33	108294	0	
6M34		Structural and functional insights into an Archaeal synthase	2020-03-02	2021-02-03	Wei, C.,Sixue, R.	Structural and mechanistic insights into the biosynthesis of Digeranylgeranylglyceryl phosphate synthase in membranes	To Be Published	0	0	0	0	
6M4S	32775708	Crystal Structure Analysis of the cytochrome P450 CYP-Sb21	2020-03-09	2021-02-03	Li, F.,Ma, L.,Zhang, X.,Chen, J.,Qi, F.,Huang, Y.,Qu, Z.,Yao, L.,Zhang, W.,Kim, E.S.,Li, S.	Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana .	Synth Syst Biotechnol	2020	5	236	243	
7BZE	33495458	Structure of Bacillus subtilis HxlR, K13A mutant	2020-04-27	2021-02-03	Zhu, R.,Zhang, G.,Jing, M.,Han, Y.,Li, J.,Zhao, J.,Li, Y.,Chen, P.R.	Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction.	Nat Commun	2021	12	581	581	
6LW4		Structure of Lpg2148/Lpg2149 complex	2020-02-07	2021-02-10	Feng, Y.,Wang, Y.,Huang, Y.,Li, D.	Structure of Lpg2148/Lpg2149 complex	To Be Published	0	0	0	0	
6XF3	33522135	Crystal structure of STING in complex with E7766	2020-06-15	2021-02-17	Kim, D.S.,Endo, A.,Fang, F.G.,Huang, K.C.,Bao, X.,Choi, H.W.,Majumder, U.,Shen, Y.Y.,Mathieu, S.,Zhu, X.,Sanders, K.,Noland, T.,Hao, M.H.,Chen, Y.,Wang, J.Y.,Yasui, S.,TenDyke, K.,Wu, J.,Ingersoll, C.,Loiacono, K.A.,Hutz, J.E.,Sarwar, N.	E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.	Chemmedchem	2021	16	1740	1743	
6XZT	33784404	Crystal structure of helicase Pif1 from Thermus oshimai mutant G110C-E410C	2020-02-05	2021-02-17	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
7D2Z	33657135	Structure of sybody SR31 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD)	2020-09-17	2021-02-17	Yao, H.,Cai, H.,Li, T.,Zhou, B.,Qin, W.,Lavillette, D.,Li, D.	A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2.	Plos Pathog.	2021	17	0	0	
7D30	33657135	Structure of sybody MR17-SR31 fusion in complex with the SARS-CoV-2 S Receptor Binding domain (RBD)	2020-09-17	2021-02-17	Yao, H.,Cai, H.,Li, T.,Zhou, B.,Qin, W.,Lavillette, D.,Li, D.	A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2.	Plos Pathog.	2021	17	0	0	
7DPM	34313527	Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab	2020-12-20	2021-02-17	Jiang, W.,Wang, J.,Jiao, S.,Gu, C.,Xu, W.,Chen, B.,Wang, R.,Chen, H.,Xie, Y.,Wang, A.,Li, G.,Zeng, D.,Zhang, J.,Zhang, M.,Wang, S.,Wang, M.,Gui, X.	Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV.	Mabs	2021	13	1953683	1953683	
7LL8	33621466	D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A	2021-02-03	2021-02-17	Marinec, P.S.,Landgraf, K.E.,Uppalapati, M.,Chen, G.,Xie, D.,Jiang, Q.,Zhao, Y.,Petriello, A.,Deshayes, K.,Kent, S.B.H.,Ault-Riche, D.,Sidhu, S.S.	A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.	Acs Chem.Biol.	2021	16	548	556	
7LL8	33621466	D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A	2021-02-03	2021-02-17	Marinec, P.S.,Landgraf, K.E.,Uppalapati, M.,Chen, G.,Xie, D.,Jiang, Q.,Zhao, Y.,Petriello, A.,Deshayes, K.,Kent, S.B.H.,Ault-Riche, D.,Sidhu, S.S.	A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.	Acs Chem.Biol.	2021	16	548	556	
6LYN	33997697	CD146 D4-D5/AA98 Fab	2020-02-14	2021-02-24	Chen, X.,Yan, H.,Liu, D.,Xu, Q.,Duan, H.,Feng, J.,Yan, X.,Xie, C.	Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146.	Iscience	2021	24	102417	102417	
7CL0	33649600	Crystal structure of human SIRT6	2020-07-20	2021-02-24	Huang, Z.,Zhao, J.,Deng, W.,Chen, Y.,Shang, J.,Song, K.,Zhang, L.,Wang, C.,Lu, S.,Yang, X.,He, B.,Min, J.,Hu, H.,Tan, M.,Xu, J.,Zhang, Q.,Zhong, J.,Sun, X.,Mao, Z.,Lin, H.,Xiao, M.,Chin, Y.E.,Jiang, H.,Shen, H.,Xu, Y.,Chen, G.,Zhang, J.	Reply to: Binding site for MDL-801 on SIRT6.	Nat.Chem.Biol.	2021	17	522	523	
7CSO	33597305	Structure of Ephexin4 DH-PH-SH3	2020-08-15	2021-02-24	Zhang, M.,Lin, L.,Wang, C.,Zhu, J.	Double inhibition and activation mechanisms of Ephexin family RhoGEFs.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7CSR	33597305	Structure of Ephexin4 R676L	2020-08-17	2021-02-24	Zhang, M.,Lin, L.,Wang, C.,Zhu, J.	Double inhibition and activation mechanisms of Ephexin family RhoGEFs.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
6M2Z		Crystal structure of a formolase, BFD variant M3 from Pseudomonas putida	2020-03-02	2021-03-03	Li, T.,Tang, Z.,Wei, H.,Tan, Z.,Liu, P.,Li, J.,Zheng, Y.,Lin, J.,Liu, W.,Jiang, H.,Liu, H.,Zhu, L.,Ma, Y.	Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediate.	Green Chem	2020	22	6809	6814	
6M3G	33589610	Crystal structure of human HPF1	2020-03-03	2021-03-03	Sun, F.H.,Zhao, P.,Zhang, N.,Kong, L.L.,Wong, C.C.L.,Yun, C.H.	HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.	Nat Commun	2021	12	1028	1028	
6M3I	33589610	Crystal structure of HPF1/PARP1 complex	2020-03-03	2021-03-03	Sun, F.H.,Zhao, P.,Zhang, N.,Kong, L.L.,Wong, C.C.L.,Yun, C.H.	HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones.	Nat Commun	2021	12	1028	1028	
7BV3		Crystal structure of a ugt transferase from Siraitia grosvenorii in complex with UDP	2020-04-09	2021-03-03	Li, J.,Qu, G.,Shang, N.,Chen, P.,Men, Y.,Liu, W.D.,Mei, Z.,Sun, Y.X.,Sun, Z.	Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases	Green Synth Catal	2021	0	0	0	
7D38	33542233	flavone reductase	2020-09-18	2021-03-03	Yang, G.,Hong, S.,Yang, P.,Sun, Y.,Wang, Y.,Zhang, P.,Jiang, W.,Gu, Y.	Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.	Nat Commun	2021	12	790	790	
7D39	33542233	FLR-apo	2020-09-18	2021-03-03	Yang, G.,Hong, S.,Yang, P.,Sun, Y.,Wang, Y.,Zhang, P.,Jiang, W.,Gu, Y.	Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.	Nat Commun	2021	12	790	790	
7D3A	33542233	flavone reductase	2020-09-18	2021-03-03	Yang, G.,Hong, S.,Yang, P.,Sun, Y.,Wang, Y.,Zhang, P.,Jiang, W.,Gu, Y.	Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.	Nat Commun	2021	12	790	790	
7D3B	33542233	flavone reductase	2020-09-18	2021-03-03	Yang, G.,Hong, S.,Yang, P.,Sun, Y.,Wang, Y.,Zhang, P.,Jiang, W.,Gu, Y.	Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.	Nat Commun	2021	12	790	790	
6M6D	33395281	Structure of HPPD complexed with a synthesized inhibitor	2020-03-14	2021-03-10	Qu, R.Y.,Nan, J.X.,Yan, Y.C.,Chen, Q.,Ndikuryayo, F.,Wei, X.F.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide.	J.Agric.Food Chem.	2021	69	459	473	
6LKH	33199635	Two-component system protein mediate signal transduction	2019-12-19	2021-03-17	Wang, M.,Guo, Q.,Zhu, K.,Fang, B.,Yang, Y.,Teng, M.,Li, X.,Tao, Y.	Interface switch mediates signal transmission in a two-component system.	Proc.Natl.Acad.Sci.USA	2020	117	30433	30440	
6M6X	33890470	Oridonin in complex with CRM1#-Ran-RanBP1	2020-03-16	2021-03-17	Lei, Y.,Li, Y.,Tan, Y.,Qian, Z.,Zhou, Q.,Jia, D.,Sun, Q.	Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.	J.Nat.Prod.	2021	84	1478	1488	
7CMZ	33952527	Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8	2020-07-29	2021-03-17	Ma, S.,Cao, C.,Che, S.,Wang, Y.,Su, D.,Liu, S.,Gong, W.,Liu, L.,Sun, J.,Zhao, J.,Wang, Q.,Song, N.,Ge, T.,Guo, Q.,Tian, S.,Chen, C.D.,Zhang, T.,Wang, J.,Ding, X.,Yang, F.,Ying, G.,Yang, J.,Zhang, K.,Zhu, Y.,Yao, Z.,Yang, N.,Shi, L.	PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.	Sci Adv	2021	7	0	0	
7D1G		Crystal structure of Glyceraldehyde-3-Phosphate Dehydrogenase GAPDH from Clostridium beijerinckii	2020-09-14	2021-03-17	Chen, Y.,Lan, J.,Liu, W.,Wang, L.,Xu, Y.	Crystal structure of Glyceraldehyde-3-Phosphate Dehydrogenase GAPDH from Clostridium beijerinckii	To Be Published	0	0	0	0	
7D8G	33955674	The crystal structure of nucleotide phosphatase Sa1684 from Staphylococcus aureus	2020-10-08	2021-03-17	Wang, Z.,Shen, H.,He, B.,Teng, M.,Guo, Q.,Li, X.	The structural mechanism for the nucleoside tri- and diphosphate hydrolysis activity of Ntdp from Staphylococcus aureus.	Febs J.	2021	288	6019	6034	
7D8L	33955674	The structure of nucleoside phosphatase Sa1684 complex with GTP analogue from Staphylococcus aureus	2020-10-08	2021-03-17	Wang, Z.,Shen, H.,He, B.,Teng, M.,Guo, Q.,Li, X.	The structural mechanism for the nucleoside tri- and diphosphate hydrolysis activity of Ntdp from Staphylococcus aureus.	Febs J.	2021	288	6019	6034	
7D8Q	33955674	The structure of nucleotide phosphatase Sa1684 complex with GDP analogue from Staphylococcus aureus	2020-10-09	2021-03-17	Wang, Z.,Shen, H.,He, B.,Teng, M.,Guo, Q.,Li, X.	The structural mechanism for the nucleoside tri- and diphosphate hydrolysis activity of Ntdp from Staphylococcus aureus.	Febs J.	2021	288	6019	6034	
7DTJ	33676181	Crystal structure of the RecA2 domain of RNA helicase CGH-1 in C. elegans	2021-01-05	2021-03-17	Zhang, Y.,Lv, M.,Li, F.,Li, M.,Zhang, J.,Shi, Y.,Hong, J.	Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.	Biochem.Biophys.Res.Commun.	2021	549	135	142	
7DTK	33676181	Crystal structure of the RecA1 domain of RNA helicase CGH-1 in C. elegans	2021-01-05	2021-03-17	Zhang, Y.,Lv, M.,Li, F.,Li, M.,Zhang, J.,Shi, Y.,Hong, J.	Structural and biochemical insights into the recognition of RNA helicase CGH-1 by CAR-1 in C. elegans.	Biochem.Biophys.Res.Commun.	2021	549	135	142	
7BPD		Crystal structural analysis of Swine dUTPase	2020-03-22	2021-03-24	Liang, R.,Peng, G.Q.	Crystal structural analysis of swine dUTPase	To Be Published	0	0	0	0	
7BYF	33033226	The crystal structure of mouse ORF10-Rae1-Nup98 complex	2020-04-22	2021-03-24	Feng, H.,Tian, H.,Wang, Y.,Zhang, Q.,Lin, N.,Liu, S.,Yu, Y.,Deng, H.,Gao, P.	Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10.	Proc.Natl.Acad.Sci.USA	2020	117	26719	26727	
7DAE	33272565	EPB in complex with tubulin	2020-10-16	2021-03-24	Xiao, Q.,Xue, T.,Shuai, W.,Wu, C.,Zhang, Z.,Zhang, T.,Zeng, S.,Sun, B.,Wang, Y.	High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.	Biochem.Biophys.Res.Commun.	2021	534	330	336	
7DAF	33272565	IXA in complex with tubulin	2020-10-16	2021-03-24	Xiao, Q.,Xue, T.,Shuai, W.,Wu, C.,Zhang, Z.,Zhang, T.,Zeng, S.,Sun, B.,Wang, Y.	High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.	Biochem.Biophys.Res.Commun.	2021	534	330	336	
7CR6	33619565	Synechocystis Cas1-Cas2/prespacer binary complex	2020-08-12	2021-03-31	Wu, C.,Tang, D.,Cheng, J.,Hu, D.,Yang, Z.,Ma, X.,He, H.,Yao, S.,Fu, T.M.,Yu, Y.,Chen, Q.	Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis.	Nucleic Acids Res.	2021	49	2973	2984	
7CR8	33619565	Synechocystis Cas1-Cas2-prespacerL complex	2020-08-12	2021-03-31	Wu, C.,Tang, D.,Cheng, J.,Hu, D.,Yang, Z.,Ma, X.,He, H.,Yao, S.,Fu, T.M.,Yu, Y.,Chen, Q.	Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis.	Nucleic Acids Res.	2021	49	2973	2984	
7D0E	33692357	Crystal structure of FIP200 Claw/p-CCPG1 FIR2	2020-09-09	2021-03-31	Zhou, Z.,Liu, J.,Fu, T.,Wu, P.,Peng, C.,Gong, X.,Wang, Y.,Zhang, M.,Li, Y.,Wang, Y.,Xu, X.,Li, M.,Pan, L.	Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation.	Nat Commun	2021	12	1570	1570	
7EA9	33784510	Crystal Structure of human lysyl-tRNA synthetase Y145H mutant	2021-03-06	2021-03-31	Wu, S.,Hei, Z.,Zheng, L.,Zhou, J.,Liu, Z.,Wang, J.,Fang, P.	Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment.	Biochem.Biophys.Res.Commun.	2021	554	83	88	
7ADA	33784404	Crystal structure of helicase Pif1 from Thermus oshimai mutant Q164C-E409C	2020-09-14	2021-04-07	Dai, Y.X.,Chen, W.F.,Liu, N.N.,Teng, F.Y.,Guo, H.L.,Hou, X.M.,Dou, S.X.,Rety, S.,Xi, X.G.	Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.	Nucleic Acids Res.	2021	49	4129	4143	
7BTT		A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain	2020-04-02	2021-04-07	Yun, C.H.,Zhu, S.J.	A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain	To Be Published	0	0	0	0	
7BTU		Crystal structure of TrmO from P. areuginosa	2020-04-03	2021-04-07	Fan, C.P.	Crystal structure of TrmO	To Be Published	0	0	0	0	
7BTZ		Crystal structure of TrmO	2020-04-03	2021-04-07	Fa, C.P.,Wang, L.,Hu, W.H.,Yang, C.W.	Crystal structure of TrmO from Pseudomonas aeruginosa	To Be Published	0	0	0	0	
7BU1		Crystal structure of TrmO from Pseudomonas aeruginosa	2020-04-03	2021-04-07	Fan, C.P.,Wang, L.,Hu, W.H.,Yang, C.W.	Crystal structure of TrmO from Pseudomonas aeruginosa	To Be Published	0	0	0	0	
7C43	33332555	The crystal structure of Trypanosoma brucei RNase D : AMP complex	2020-05-14	2021-04-07	Gao, Y.,Liu, H.,Zhang, C.,Su, S.,Chen, Y.,Chen, X.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Li, J.,Huang, Z.,Ma, J.,Gan, J.	Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.	Nucleic Acids Res.	2021	49	568	583	
7C47	33332555	The crystal structure of Trypanosoma brucei RNase D : CMP complex	2020-05-15	2021-04-07	Gao, Y.,Liu, H.,Zhang, C.,Su, S.,Chen, Y.,Chen, X.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Li, J.,Huang, Z.,Ma, J.,Gan, J.	Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.	Nucleic Acids Res.	2021	49	568	583	
7C4B	33332555	The crystal structure of Trypanosoma brucei RNase D : UMP complex	2020-05-15	2021-04-07	Gao, Y.,Liu, H.,Zhang, C.,Su, S.,Chen, Y.,Chen, X.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Li, J.,Huang, Z.,Ma, J.,Gan, J.	Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.	Nucleic Acids Res.	2021	49	568	583	
7C4C	33332555	The crystal structure of Trypanosoma brucei RNase D : GMP complex	2020-05-15	2021-04-07	Gao, Y.,Liu, H.,Zhang, C.,Su, S.,Chen, Y.,Chen, X.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Li, J.,Huang, Z.,Ma, J.,Gan, J.	Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.	Nucleic Acids Res.	2021	49	568	583	
7CD9	33511756	Crystal Structure of SETDB1 tudor domain in complexed with Compound 6	2020-06-19	2021-04-07	Guo, Y.,Mao, X.,Xiong, L.,Xia, A.,You, J.,Lin, G.,Wu, C.,Huang, L.,Wang, Y.,Yang, S.	Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.	Angew.Chem.Int.Ed.Engl.	2021	60	8760	8765	
7CZH	33771786	PL24 ulvan lyase-Uly1	2020-09-08	2021-04-07	Xu, F.,Dong, F.,Sun, X.H.,Cao, H.Y.,Fu, H.H.,Li, C.Y.,Zhang, X.Y.,McMinn, A.,Zhang, Y.Z.,Wang, P.,Chen, X.L.	Mechanistic Insights into Substrate Recognition and Catalysis of a New Ulvan Lyase of Polysaccharide Lyase Family 24.	Appl.Environ.Microbiol.	2021	87	0	0	
7DII	33811858	Crystal structure of LeuT in lipidic cubic phase at pH 7	2020-11-19	2021-04-07	Fan, J.,Xiao, Y.,Quick, M.,Yang, Y.,Sun, Z.,Javitch, J.A.,Zhou, X.	Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.	J.Biol.Chem.	2021	296	100609	100609	
7DIX	33811858	Crystal structure of LeuT in lipidic cubic phase at pH 5	2020-11-19	2021-04-07	Fan, J.,Xiao, Y.,Quick, M.,Yang, Y.,Sun, Z.,Javitch, J.A.,Zhou, X.	Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.	J.Biol.Chem.	2021	296	100609	100609	
7E3J	34234119	Crystal structure of SARS-CoV-2 RBD binding to dog ACE2	2021-02-08	2021-04-07	Zhang, Z.,Zhang, Y.,Liu, K.,Li, Y.,Lu, Q.,Wang, Q.,Zhang, Y.,Wang, L.,Liao, H.,Zheng, A.,Ma, S.,Fan, Z.,Li, H.,Huang, W.,Bi, Y.,Zhao, X.,Wang, Q.,Gao, G.F.,Xiao, H.,Tong, Z.,Qi, J.,Sun, Y.	The molecular basis for SARS-CoV-2 binding to dog ACE2.	Nat Commun	2021	12	4195	4195	
7BPU		Structural and mechanistic insights into the biosynthesis of Digeranylgeranylglyceryl phosphate synthase in membranes	2020-03-23	2021-04-14	Ren, S.,de Kok, N.A.,Gu, Y.,Yan, W.,Sun, Q.,Chen, Y.,He, J.,Tian, L.,Andringa, R.L.,Zhu, X.,Tang, M.,Qi, S.,Xu, H.,Ren, H.,Fu, X.,Minnaard, A.J.,Yang, S.,Zhang, W.,Li, W.,Wei, Y.,Driessen, A.J.,Cheng, W.	Structural and Functional Insights into an Archaeal Lipid Synthase	Cell Rep	2020	33	108294	0	
7CHU	32926904	Geobacillus virus E2 - ORF18	2020-07-06	2021-04-14	Zhang, L.,Yan, Y.,Gan, Q.,She, Z.,Zhu, K.,Wang, J.,Gao, Z.,Dong, Y.,Gong, Y.	Structural and functional characterization of the deep-sea thermophilic bacteriophage GVE2 tailspike protein.	Int.J.Biol.Macromol.	2020	164	4415	4422	
7EDR	33765559	The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin	2021-03-16	2021-04-14	Zhang, F.,Liu, B.,Gao, Y.,Long, J.,Zhou, H.	The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin.	Biochem.Biophys.Res.Commun.	2021	553	92	98	
7L1G	33755465	PRMT5-MEP50 Complexed with SAM	2020-12-14	2021-04-14	Candito, D.A.,Ye, Y.,Quiroz, R.V.,Reutershan, M.H.,Witter, D.,Gadamsetty, S.B.,Li, H.,Sauri, J.,Schneider, S.E.,Lam, Y.H.,Palte, R.L.	Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4- b ]furan Nucleoside Analogues.	J.Org.Chem.	2021	86	5142	5151	
7BXB		Crystal structure of Ca_00311	2020-04-18	2021-04-21	Fan, C.P.	crystal structure of Ca_00311	To Be Published	0	0	0	0	
7BXC		Crystal structure of Ca_00311 form II	2020-04-19	2021-04-21	Fan, C.P.	Crystal structure of Ca_00311 form II	To Be Published	0	0	0	0	
7BXD		Crystal structure of Ca_00815	2020-04-19	2021-04-21	Fan, C.P.	Crystal structure of Ca_00815	To Be Published	0	0	0	0	
7CGS	33146944	Crystal endo-deglycosylated hydroxynitrile lyase isozyme 5 mutant L343F from Prunus communis	2020-07-02	2021-04-21	Zheng, Y.C.,Ding, L.Y.,Jia, Q.,Lin, Z.,Hong, R.,Yu, H.L.,Xu, J.H.	A High-Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis.	Chembiochem	2021	22	996	1000	
7KIC	33755451	PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34	2020-10-23	2021-04-21	Quiroz, R.V.,Reutershan, M.H.,Schneider, S.E.,Sloman, D.,Lacey, B.M.,Swalm, B.M.,Yeung, C.S.,Gibeau, C.,Spellman, D.S.,Rankic, D.A.,Chen, D.,Witter, D.,Linn, D.,Munsell, E.,Feng, G.,Xu, H.,Hughes, J.M.E.,Lim, J.,Sauri, J.,Geddes, K.,Wan, M.,Mansueto, M.S.,Follmer, N.E.,Fier, P.S.,Siliphaivanh, P.,Daublain, P.,Palte, R.L.,Hayes, R.P.,Lee, S.,Kawamura, S.,Silverman, S.,Sanyal, S.,Henderson, T.J.,Ye, Y.,Gao, Y.,Nicholson, B.,Machacek, M.R.	The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.	J.Med.Chem.	2021	64	3911	3939	
7KID	33755451	PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72	2020-10-23	2021-04-21	Quiroz, R.V.,Reutershan, M.H.,Schneider, S.E.,Sloman, D.,Lacey, B.M.,Swalm, B.M.,Yeung, C.S.,Gibeau, C.,Spellman, D.S.,Rankic, D.A.,Chen, D.,Witter, D.,Linn, D.,Munsell, E.,Feng, G.,Xu, H.,Hughes, J.M.E.,Lim, J.,Sauri, J.,Geddes, K.,Wan, M.,Mansueto, M.S.,Follmer, N.E.,Fier, P.S.,Siliphaivanh, P.,Daublain, P.,Palte, R.L.,Hayes, R.P.,Lee, S.,Kawamura, S.,Silverman, S.,Sanyal, S.,Henderson, T.J.,Ye, Y.,Gao, Y.,Nicholson, B.,Machacek, M.R.	The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.	J.Med.Chem.	2021	64	3911	3939	
6K9X	24419374	Crystal Structure Analysis of Protein	2019-06-18	2021-04-28	Wan, Q.	X-ray crystallographic studies of family 11 xylanase Michaelis and product complexes: implications for the catalytic mechanism	Acta Crystallographica Section	2014	0	11	23	
6LU5		Crystal structure of BPTF-BRD with ligand DCBPin5 bound	2020-01-25	2021-04-28	Lu, T.,Lu, H.B.,Wang, J.,Han, J.,Xiao, S.,Jiang, H.,Chen, Y.,Yang, F.,Li, Q.,Jiang, H.L.,Chen, K.X.,Lu, W.C.,Lin, H.,Luo, C.	Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins	To Be Published	0	0	0	0	
6LU6		Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound	2020-01-26	2021-04-28	Lu, T.,Lu, H.B.,Wang, J.,Han, J.,Xiao, S.,Jiang, H.,Chen, Y.,Yang, F.,Li, Q.,Jiang, H.L.,Chen, K.X.,Lu, W.C.,Lin, H.,Luo, C.	Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins	To Be Published	0	0	0	0	
6ZD1	33856462	Structure of apo telomerase from Candida Tropicalis	2020-06-13	2021-04-28	Zhai, L.T.,Rety, S.,Chen, W.F.,Song, Z.Y.,Auguin, D.,Sun, B.,Dou, S.X.,Xi, X.G.	Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.	Nucleic Acids Res.	2021	49	4768	4781	
6ZD2	33856462	Structure of apo telomerase from Candida Tropicalis truncated from C-terminal domain	2020-06-13	2021-04-28	Zhai, L.T.,Rety, S.,Chen, W.F.,Song, Z.Y.,Auguin, D.,Sun, B.,Dou, S.X.,Xi, X.G.	Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.	Nucleic Acids Res.	2021	49	4768	4781	
6ZDP	33856462	Structure of telomerase from Candida Tropicalis in complexe with TWJ fragment of telomeric RNA	2020-06-15	2021-04-28	Zhai, L.T.,Rety, S.,Chen, W.F.,Song, Z.Y.,Auguin, D.,Sun, B.,Dou, S.X.,Xi, X.G.	Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.	Nucleic Acids Res.	2021	49	4768	4781	
6ZDQ	33856462	Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA	2020-06-15	2021-04-28	Zhai, L.T.,Rety, S.,Chen, W.F.,Song, Z.Y.,Auguin, D.,Sun, B.,Dou, S.X.,Xi, X.G.	Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.	Nucleic Acids Res.	2021	49	4768	4781	
7C7M	33826776	The structure of SAM-bound CntL, an aminobutyrate transferase in staphylopine biosysnthesis	2020-05-26	2021-04-28	Luo, Z.,Luo, S.,Ju, Y.,Ding, P.,Xu, J.,Gu, Q.,Zhou, H.	Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis.	Faseb J.	2021	35	0	0	
7C9M	33826776	The structure of product-bound CntL, an aminobutyrate transferase in staphylopine biosynthesis	2020-06-06	2021-04-28	Luo, Z.,Luo, S.,Ju, Y.,Ding, P.,Xu, J.,Gu, Q.,Zhou, H.	Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis.	Faseb J.	2021	35	0	0	
7DBI	33843134	Crystal structure of the peroxisomal acyl-CoA hydrolase MpaH	2020-10-20	2021-04-28	You, C.,Li, F.,Zhang, X.,Ma, L.,Zhang, Y.Z.,Zhang, W.,Li, S.	Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis.	Febs J.	2021	288	5768	5780	
7DBL	33843134	Acyl-CoA hydrolase MpaH' mutant S139A in complex with MPA	2020-10-20	2021-04-28	You, C.,Li, F.,Zhang, X.,Ma, L.,Zhang, Y.Z.,Zhang, W.,Li, S.	Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis.	Febs J.	2021	288	5768	5780	
7C0G		Aca1 in complex with 14bp palindromic DNA target	2020-05-01	2021-05-05	Liu, Y.H.,Zhang, L.S.,Wu, B.X.,Huang, H.D.	Aca1  in complex with 14bp palindromic DNA target	To Be Published	0	0	0	0	
7C1E		Crystal structure of Kluyveromyces polyspora ADH (KpADH) mutant (Y127W)	2020-05-03	2021-05-05	Wu, Y.F.,Zhou, J.Y.,Ni, J.,Zhu, C.,Sun, Z.,Xu, G.C.,Ni, Y.	Engineering an Alcohol Dehydrogenase from Kluyveromyces polyspora for Efficient Synthesis of Ibrutinib Intermediate	Adv.Synth.Catal.	2021	0	0	0	
7EMN	33722610	The atomic structure of SHP2 E76A mutant	2021-04-14	2021-05-05	Tao, Y.,Xie, J.,Zhong, Q.,Wang, Y.,Zhang, S.,Luo, F.,Wen, F.,Xie, J.,Zhao, J.,Sun, X.,Long, H.,Ma, J.,Zhang, Q.,Long, J.,Fang, X.,Lu, Y.,Li, D.,Li, M.,Zhu, J.,Sun, B.,Li, G.,Diao, J.,Liu, C.	A novel partially open state of SHP2 points to a ""multiple gear"" regulation mechanism.	J.Biol.Chem.	2021	296	100538	100538	
6W45	33955740	Crystal structure of HAO1 in complex with biaryl acid inhibitor - compound 3	2020-03-10	2021-05-12	Lee, E.C.Y.,McRiner, A.J.,Georgiadis, K.E.,Liu, J.,Wang, Z.,Ferguson, A.D.,Levin, B.,von Rechenberg, M.,Hupp, C.D.,Monteiro, M.I.,Keefe, A.D.,Olszewski, A.,Eyermann, C.J.,Centrella, P.,Liu, Y.,Arora, S.,Cuozzo, J.W.,Zhang, Y.,Clark, M.A.,Huguet, C.,Kohlmann, A.	Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.	J.Med.Chem.	2021	64	6730	6744	
7C7R	34046916	Biofilm associated protein - B domain	2020-05-26	2021-05-12	Ma, J.,Cheng, X.,Xu, Z.,Zhang, Y.,Valle, J.,Fan, S.,Zuo, X.,Lasa, I.,Fang, X.	Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch.	Embo J.	2021	40	0	0	
7C7U	34046916	Biofilm associated protein - BSP domain	2020-05-26	2021-05-12	Ma, J.,Cheng, X.,Xu, Z.,Zhang, Y.,Valle, J.,Fan, S.,Zuo, X.,Lasa, I.,Fang, X.	Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch.	Embo J.	2021	40	0	0	
7EL6	33892462	Structure of SMCR8 bound FEM1B	2021-04-08	2021-05-12	Zhao, S.,Ru, W.,Chen, X.,Liao, S.,Zhu, Z.,Zhang, J.,Xu, C.	Structural insights into SMCR8 C-degron recognition by FEM1B.	Biochem.Biophys.Res.Commun.	2021	557	236	239	
7DFT	34218658	Crystal structure of Xanthomonas oryzae ClpP	2020-11-09	2021-05-19	Yang, T.,Zhang, T.,Zhou, X.,Wang, P.,Gan, J.,Song, B.,Yang, S.,Yang, C.G.	Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections.	J.Agric.Food Chem.	2021	69	7545	7553	
7DFU	34218658	Crystal structure of Xanthomonas oryzae ClpP S68Y in complex with ADEP4.	2020-11-09	2021-05-19	Yang, T.,Zhang, T.,Zhou, X.,Wang, P.,Gan, J.,Song, B.,Yang, S.,Yang, C.G.	Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections.	J.Agric.Food Chem.	2021	69	7545	7553	
6LE7		Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 2	2019-11-24	2021-05-26	Chen, Q.,Yang, Q.,Zhou, Y.	Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 2	To Be Published	0	0	0	0	
6LE8		Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 1	2019-11-24	2021-05-26	Chen, Q.,Yang, Q.,Zhou, Y.	Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 1	To Be Published	0	0	0	0	
7C4D	33445864	Marine microorganism esterase	2020-05-16	2021-05-26	Zhu, C.,Chen, Y.,Isupov, M.N.,Littlechild, J.A.,Sun, L.,Liu, X.,Wang, Q.,Gong, H.,Dong, P.,Zhang, N.,Wu, Y.	Structural Insights into a Novel Esterase from the East Pacific Rise and Its Improved Thermostability by a Semirational Design.	J.Agric.Food Chem.	2021	69	1079	1090	
7C5C		Crystal structure of SeFRS	2020-05-19	2021-05-26	Sun, J.P.,Wang, J.Y.,Zhu, Z.L.,He, Q.T.	CRYSTAL STRUCTURE OF SeFRS	To Be Published	0	0	0	0	
7C5M	34827563	Crystal Structure of C150A+H177A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with G3P at 1.8 Angstrom resolution	2020-05-20	2021-05-26	Zhang, L.,Liu, M.,Bao, L.,Bostrom, K.I.,Yao, Y.,Li, J.,Gu, S.,Ji, C.	Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.	Biomolecules	2021	11	0	0	
7C78		The crystal structure of type I-F anti-crispr protein AcrIF9	2020-05-24	2021-05-26	Niu, Y.,Feng, Y.	The crystal structure of type I-F anti-crispr protein AcrIF9	To Be Published	0	0	0	0	
7C7K	34827563	Crystal Structure of Thioacyl-Glyceraldehyde-3-phosphate dehydrogenase 1(GAPDH 1) from Escherichia coli at 1.77 Angstrom resolution	2020-05-26	2021-05-26	Zhang, L.,Liu, M.,Bao, L.,Bostrom, K.I.,Yao, Y.,Li, J.,Gu, S.,Ji, C.	Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.	Biomolecules	2021	11	0	0	
7CK8		Crystal structure of human ferritin heavy chain mutant C90S/C102S/C130S	2020-07-16	2021-05-26	Jiang, B.,Chen, X.,Sun, G.,Chen, X.,Yin, Y.,Jin, Y.,Mi, Q.,Ma, L.,Yang, Y.,Yan, X.,Fan, K.	A natural drug entry channel in the ferritin nanocage.	Nano Today	2020	35	0	0	
7CK9		Crystal structure of Doxorubicin loaded human ferritin heavy chain	2020-07-16	2021-05-26	Jiang, B.,Chen, X.,Sun, G.,Chen, X.,Yin, Y.,Jin, Y.,Mi, Q.,Ma, L.,Yang, Y.,Yan, X.,Fan, K.	A natural drug entry channel in the ferritin nanocage.	Nano Today	2020	35	0	0	
7DIE	33852289	Crystal structure of M. penetrans Ferritin	2020-11-19	2021-05-26	Wang, W.,Zhang, Y.,Zhao, G.,Wang, H.	Ferritin with Atypical Ferroxidase Centers Takes B-Channels as the Pathway for Fe 2+ Uptake from Mycoplasma .	Inorg.Chem.	2021	60	7207	7216	
7EGL	34031249	Bicarbonate transporter complex SbtA-SbtB bound to HCO3-	2021-03-24	2021-05-26	Fang, S.,Huang, X.,Zhang, X.,Zhang, M.,Hao, Y.,Guo, H.,Liu, L.N.,Yu, F.,Zhang, P.	Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7CFB	34210982	Drosophila melanogaster Krimper eTud1 apo structure	2020-06-25	2021-06-02	Huang, X.,Hu, H.,Webster, A.,Zou, F.,Du, J.,Patel, D.J.,Sachidanandam, R.,Toth, K.F.,Aravin, A.A.,Li, S.	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.	Nat Commun	2021	12	4061	4061	
7CFC	34210982	Drosophila melanogaster Krimper eTud1-Ago3 complex	2020-06-25	2021-06-02	Huang, X.,Hu, H.,Webster, A.,Zou, F.,Du, J.,Patel, D.J.,Sachidanandam, R.,Toth, K.F.,Aravin, A.A.,Li, S.	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.	Nat Commun	2021	12	4061	4061	
7CFD	34210982	Drosophila melanogaster Krimper eTud2-AubR15me2 complex	2020-06-25	2021-06-02	Huang, X.,Hu, H.,Webster, A.,Zou, F.,Du, J.,Patel, D.J.,Sachidanandam, R.,Toth, K.F.,Aravin, A.A.,Li, S.	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.	Nat Commun	2021	12	4061	4061	
7DV7	33865894	Structure of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5.	2021-01-12	2021-06-02	Liu, W.,Ma, C.,Liu, W.,Zheng, Y.,Chen, C.C.,Liang, A.,Luo, X.,Li, Z.,Ma, W.,Song, Y.,Guo, R.T.,Zhang, T.	Functional and structural investigation of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5.	Int.J.Biol.Macromol.	2021	182	899	909	
7DVJ	33865894	Structure of beta-mannanase BaMan113A with mannobiose	2021-01-13	2021-06-02	Liu, W.,Ma, C.,Liu, W.,Zheng, Y.,Chen, C.C.,Liang, A.,Luo, X.,Li, Z.,Ma, W.,Song, Y.,Guo, R.T.,Zhang, T.	Functional and structural investigation of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5.	Int.J.Biol.Macromol.	2021	182	899	909	
7DVZ	33865894	Structure of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5, N236Y mutation.	2021-01-15	2021-06-02	Liu, W.,Ma, C.,Liu, W.,Zheng, Y.,Chen, C.C.,Liang, A.,Luo, X.,Li, Z.,Ma, W.,Song, Y.,Guo, R.T.,Zhang, T.	Functional and structural investigation of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5.	Int.J.Biol.Macromol.	2021	182	899	909	
7DW8	33865894	Structure of a novel beta-mannanase BaMan113A with mannobiose, N236Y mutation.	2021-01-15	2021-06-02	Liu, W.,Ma, C.,Liu, W.,Zheng, Y.,Chen, C.C.,Liang, A.,Luo, X.,Li, Z.,Ma, W.,Song, Y.,Guo, R.T.,Zhang, T.	Functional and structural investigation of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5.	Int.J.Biol.Macromol.	2021	182	899	909	
7DWA	33865894	Structure of a novel beta-mannanase BaMan113A with mannotriose, N236Y mutation	2021-01-15	2021-06-02	Liu, W.,Ma, C.,Liu, W.,Zheng, Y.,Chen, C.C.,Liang, A.,Luo, X.,Li, Z.,Ma, W.,Song, Y.,Guo, R.T.,Zhang, T.	Functional and structural investigation of a novel beta-mannanase BaMan113A from Bacillus sp. N16-5.	Int.J.Biol.Macromol.	2021	182	899	909	
7EAF	33978763	Crystal structure of SAM-I riboswitch with the Actinomyces-1 k-turn	2021-03-07	2021-06-02	Huang, L.,Liao, X.,Li, M.,Wang, J.,Peng, X.,Wilson, T.J.,Lilley, D.M.J.	Structure and folding of four putative kink turns identified in structured RNA species in a test of structural prediction rules.	Nucleic Acids Res.	2021	49	5916	5924	
7EAF	33978763	Crystal structure of SAM-I riboswitch with the Actinomyces-1 k-turn	2021-03-07	2021-06-02	Huang, L.,Liao, X.,Li, M.,Wang, J.,Peng, X.,Wilson, T.J.,Lilley, D.M.J.	Structure and folding of four putative kink turns identified in structured RNA species in a test of structural prediction rules.	Nucleic Acids Res.	2021	49	5916	5924	
6LWC	34226550	Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing spiroiminodihydantoin (Sp)	2020-02-07	2021-06-09	Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C.	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.	Nat Commun	2021	12	4108	4108	
6LWF	34226550	Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing guanidinohydantoin (Gh)	2020-02-07	2021-06-09	Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C.	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.	Nat Commun	2021	12	4108	4108	
6LWR	34226550	Crystal structure of human NEIL1(K242) bound to duplex DNA containing a cleaved C:T mismatch	2020-02-07	2021-06-09	Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C.	DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.	Nat Commun	2021	12	4108	4108	
7CSA	33990581	AtPrR1 with NADP+	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7CSB	33990581	AtPrR1 with NADP+ and (+)pinoresinol	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7CSC	33990581	AtPrR1 with NADP+ and (-)pinoresinol	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7CSD	33990581	AtPrR1 with NADP+ and (+)lariciresinol	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7CSE	33990581	AtPrR1 with NADP+ and (-)lariciresinol	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7CSF	33990581	AtPrR1 with NADP+ and (-)secoisolariciresinol	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7CSG	33990581	AtPrR2 in apo form	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7CSH	33990581	AtPrR2 with NADP+ and (+)pinoresinol	2020-08-14	2021-06-09	Xiao, Y.,Shao, K.,Zhou, J.,Wang, L.,Ma, X.,Wu, D.,Yang, Y.,Chen, J.,Feng, J.,Qiu, S.,Lv, Z.,Zhang, L.,Zhang, P.,Chen, W.	Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.	Nat Commun	2021	12	2828	2828	
7DH7	34048589	Crystal structure of apo XcZur	2020-11-13	2021-06-09	Liu, F.,Su, Z.,Chen, P.,Tian, X.,Wu, L.,Tang, D.J.,Li, P.,Deng, H.,Ding, P.,Fu, Q.,Tang, J.L.,Ming, Z.	Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator.	Nucleic Acids Res.	2021	49	6511	6528	
7DJZ	35332252	Crystal structure of SARS-CoV-2 Spike RBD in complex with MW01 Fab	2020-11-22	2021-06-09	Wang, S.,Wang, J.,Yu, X.,Jiang, W.,Chen, S.,Wang, R.,Wang, M.,Jiao, S.,Yang, Y.,Wang, W.,Chen, H.,Chen, B.,Gu, C.,Liu, C.,Wang, A.,Wang, M.,Li, G.,Guo, C.,Liu, D.,Zhang, J.,Zhang, M.,Wang, L.,Gui, X.	Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc gamma RIIB and virus-antibody complex with bivalent interaction.	Commun Biol	2022	5	262	262	
7DK0	35332252	Crystal structure of SARS-CoV-2 Spike RBD in complex with MW05 Fab	2020-11-22	2021-06-09	Wang, S.,Wang, J.,Yu, X.,Jiang, W.,Chen, S.,Wang, R.,Wang, M.,Jiao, S.,Yang, Y.,Wang, W.,Chen, H.,Chen, B.,Gu, C.,Liu, C.,Wang, A.,Wang, M.,Li, G.,Guo, C.,Liu, D.,Zhang, J.,Zhang, M.,Wang, L.,Gui, X.	Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc gamma RIIB and virus-antibody complex with bivalent interaction.	Commun Biol	2022	5	262	262	
7ECF	34048588	Crystal Structure of d(G4C2)2-Ba in C2221 space group	2021-03-12	2021-06-09	Geng, Y.,Liu, C.,Cai, Q.,Luo, Z.,Miao, H.,Shi, X.,Xu, N.,Fung, C.P.,Choy, T.T.,Yan, B.,Li, N.,Qian, P.,Zhou, B.,Zhu, G.	Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence.	Nucleic Acids Res.	2021	49	5881	5890	
7EK6	34057039	Structure of viral peptides IPB19/N52	2021-04-04	2021-06-09	Yu, D.,Zhu, Y.,Jiao, T.,Wu, T.,Xiao, X.,Qin, B.,Chong, H.,Lei, X.,Ren, L.,Cui, S.,Wang, J.,He, Y.	Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants.	Emerg Microbes Infect	2021	10	1227	1240	
7CPC	33197176	His-Mediated Reversible Self-assembly of Ferritin Nanocage with Ni binding	2020-08-06	2021-06-16	Gu, C.,Zhang, T.,Lv, C.,Liu, Y.,Wang, Y.,Zhao, G.	His-Mediated Reversible Self-Assembly of Ferritin Nanocages through Two Different Switches for Encapsulation of Cargo Molecules.	Acs Nano	2020	0	0	0	
7CPI	33197176	His-Mediated Reversible Self-assembly of Ferritin Nanocage with Zn binding	2020-08-07	2021-06-16	Gu, C.,Zhang, T.,Lv, C.,Liu, Y.,Wang, Y.,Zhao, G.	His-Mediated Reversible Self-Assembly of Ferritin Nanocages through Two Different Switches for Encapsulation of Cargo Molecules.	Acs Nano	2020	0	0	0	
7CVO	33693873	crystal structure of Arabidopsis CO CCT domain in complex with NF-YB3/YC4 and FT CORE2 DNA	2020-08-26	2021-06-16	Lv, X.,Zeng, X.,Hu, H.,Chen, L.,Zhang, F.,Liu, R.,Liu, Y.,Zhou, X.,Wang, C.,Wu, Z.,Kim, C.,He, Y.,Du, J.	Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex.	Plant Cell	2021	33	1182	1195	
7CVQ	33693873	crystal structure of Arabidopsis CO CCT domain in complex with NF-YB2/YC3 and FT CORE1 DNA	2020-08-26	2021-06-16	Lv, X.,Zeng, X.,Hu, H.,Chen, L.,Zhang, F.,Liu, R.,Liu, Y.,Zhou, X.,Wang, C.,Wu, Z.,Kim, C.,He, Y.,Du, J.	Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex.	Plant Cell	2021	33	1182	1195	
6LQ9	33974430	S109 in complex with CRM1-Ran-RanBP1	2020-01-13	2021-06-23	Lei, Y.,An, Q.,Shen, X.F.,Sui, M.,Li, C.,Jia, D.,Luo, Y.,Sun, Q.	Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1.	J.Med.Chem.	2021	64	6596	6607	
7CBZ	34081857	Crystal structure of T2R-TTL-A31 complex	2020-06-15	2021-06-23	Wang, L.,Zheng, Y.,Li, D.,Yang, J.,Lei, L.,Yan, W.,Zheng, W.,Tang, M.,Shi, M.,Zhang, R.,Cai, X.,Ni, H.,Ma, X.,Li, N.,Hong, F.,Ye, H.,Chen, L.	Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.	J.Med.Chem.	2021	64	8127	8141	
7CDA	35762925	Crystal structure of T2R-TTL-PAC complex	2020-06-19	2021-06-23	Yang, J.,Li, Y.,Qiu, Q.,Wang, R.,Yan, W.,Yu, Y.,Niu, L.,Pei, H.,Wei, H.,Ouyang, L.,Ye, H.,Xu, D.,Wei, Y.,Chen, Q.,Chen, L.	Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.	J.Med.Chem.	2022	65	9159	9173	
7CDY		Crystal structure of glucose dehydrogenase	2020-06-21	2021-06-23	Jia, S.,Xu, D.,Wang, W.,Ran, T.	Structure of glucose dehydrogenase at 1.33 Angstroms	To Be Published	0	0	0	0	
7CE8	35762925	Crystal structure of T2R-TTL-Compound11 complex	2020-06-22	2021-06-23	Yang, J.,Li, Y.,Qiu, Q.,Wang, R.,Yan, W.,Yu, Y.,Niu, L.,Pei, H.,Wei, H.,Ouyang, L.,Ye, H.,Xu, D.,Wei, Y.,Chen, Q.,Chen, L.	Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.	J.Med.Chem.	2022	65	9159	9173	
7CQH	33326749	Complex of TRP_CBS2 and Calmodulin_Clobe	2020-08-10	2021-06-23	Chen, W.,Shen, Z.,Asteriti, S.,Chen, Z.,Ye, F.,Sun, Z.,Wan, J.,Montell, C.,Hardie, R.C.,Liu, W.,Zhang, M.	Calmodulin binds to Drosophila TRP with an unexpected mode.	Structure	2021	29	330	0	
7CQP	33326749	Complex of TRPC4 and Calmodulin_Nlobe	2020-08-11	2021-06-23	Chen, W.,Shen, Z.,Asteriti, S.,Chen, Z.,Ye, F.,Sun, Z.,Wan, J.,Montell, C.,Hardie, R.C.,Liu, W.,Zhang, M.	Calmodulin binds to Drosophila TRP with an unexpected mode.	Structure	2021	29	330	0	
7CQV	33326749	Complex of TRP_CBS1 and Calmodulin_Nlobe	2020-08-11	2021-06-23	Chen, W.,Shen, Z.,Asteriti, S.,Chen, Z.,Ye, F.,Sun, Z.,Wan, J.,Montell, C.,Hardie, R.C.,Liu, W.,Zhang, M.	Calmodulin binds to Drosophila TRP with an unexpected mode.	Structure	2021	29	330	0	
7CUU	34075025	Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with MG132	2020-08-24	2021-06-23	Wang, Z.,Zhao, Y.,Wang, Q.,Xing, Y.,Feng, L.,Kong, J.,Peng, C.,Zhang, L.,Yang, H.,Lu, M.	Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M pro .	Signal Transduct Target Ther	2021	6	214	214	
7F0W		Crystal structure of KRAS-G12D bound to GDP with switch 1 open conformation	2021-06-07	2021-06-23	Zhang, F.	Crystal structure of KRAS-G12D bound to GDP with switch 1 open conformation	To Be Published	0	0	0	0	
7CE6	35762925	Crystal structure of T2R-TTL-Compound9 complex	2020-06-22	2021-06-30	Yang, J.,Li, Y.,Qiu, Q.,Wang, R.,Yan, W.,Yu, Y.,Niu, L.,Pei, H.,Wei, H.,Ouyang, L.,Ye, H.,Xu, D.,Wei, Y.,Chen, Q.,Chen, L.	Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.	J.Med.Chem.	2022	65	9159	9173	
7CG5		Structure of the sensor domain (long construct) of the anti-sigma factor RsgI4 in Pseudobacteroides cellulosolvens	2020-06-30	2021-06-30	Dong, S.,Chen, C.,Feng, Y.	Structure of the sensor domain of the anti-sigma factor RsgI4 in Pseudobacteroides cellulosolvens	To Be Published	0	0	0	0	
7EEZ	33913587	crystal structure of maize SHH2 SAWADEE domain	2021-03-20	2021-06-30	Wang, Y.,Zhou, X.,Luo, J.,Lv, S.,Liu, R.,Du, X.,Jia, B.,Yuan, F.,Zhang, H.,Du, J.	Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.	J Integr Plant Biol	2021	63	1091	1096	
7EF0	33913587	Crystal structure of maize SHH2 SAWADEE domain in complex with an H3K9M peptide	2021-03-20	2021-06-30	Wang, Y.,Zhou, X.,Luo, J.,Lv, S.,Liu, R.,Du, X.,Jia, B.,Yuan, F.,Zhang, H.,Du, J.	Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.	J Integr Plant Biol	2021	63	1091	1096	
7EF1	33913587	crystal structure of maize SHH2 SAWADEE domain in complex with and H3K9me1 peptide	2021-03-20	2021-06-30	Wang, Y.,Zhou, X.,Luo, J.,Lv, S.,Liu, R.,Du, X.,Jia, B.,Yuan, F.,Zhang, H.,Du, J.	Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.	J Integr Plant Biol	2021	63	1091	1096	
7EF2	33913587	Crystal structure of maize SHH2 SAWADEE domain in complex with an H3K9me3 peptide	2021-03-20	2021-06-30	Wang, Y.,Zhou, X.,Luo, J.,Lv, S.,Liu, R.,Du, X.,Jia, B.,Yuan, F.,Zhang, H.,Du, J.	Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.	J Integr Plant Biol	2021	63	1091	1096	
7EF3	33913587	crystal structure of maize SHH2 SAWADEE domain in complex with H3K9me2 peptide	2021-03-20	2021-06-30	Wang, Y.,Zhou, X.,Luo, J.,Lv, S.,Liu, R.,Du, X.,Jia, B.,Yuan, F.,Zhang, H.,Du, J.	Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.	J Integr Plant Biol	2021	63	1091	1096	
7EGV	34132537	Acetolactate Synthase from Trichoderma harzianum with inhibitor harzianic acid	2021-03-26	2021-06-30	Xie, L.,Zang, X.,Cheng, W.,Zhang, Z.,Zhou, J.,Chen, M.,Tang, Y.	Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase.	J.Am.Chem.Soc.	2021	0	0	0	
7EGV	34132537	Acetolactate Synthase from Trichoderma harzianum with inhibitor harzianic acid	2021-03-26	2021-06-30	Xie, L.,Zang, X.,Cheng, W.,Zhang, Z.,Zhou, J.,Chen, M.,Tang, Y.	Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase.	J.Am.Chem.Soc.	2021	0	0	0	
7EHE	34132537	Acetolactate Synthase from Trichoderma harzianum	2021-03-29	2021-06-30	Xie, L.,Zang, X.,Cheng, W.,Zhang, Z.,Zhou, J.,Chen, M.,Tang, Y.	Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase.	J.Am.Chem.Soc.	2021	0	0	0	
7EHE	34132537	Acetolactate Synthase from Trichoderma harzianum	2021-03-29	2021-06-30	Xie, L.,Zang, X.,Cheng, W.,Zhang, Z.,Zhou, J.,Chen, M.,Tang, Y.	Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase.	J.Am.Chem.Soc.	2021	0	0	0	
7ELP	34125892	Crystal structure of xanthine riboswitch with xanthine, iridium hexammine soak	2021-04-12	2021-06-30	Xu, X.,Egger, M.,Chen, H.,Bartosik, K.,Micura, R.,Ren, A.	Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition.	Nucleic Acids Res.	2021	49	7139	7153	
7ELQ	34125892	Crystal structure of xanthine riboswitch with xanthine, manganese saok	2021-04-12	2021-06-30	Xu, X.,Egger, M.,Chen, H.,Bartosik, K.,Micura, R.,Ren, A.	Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition.	Nucleic Acids Res.	2021	49	7139	7153	
7ELR	34125892	Crystal structure of xanthine riboswitch with xanthine	2021-04-12	2021-06-30	Xu, X.,Egger, M.,Chen, H.,Bartosik, K.,Micura, R.,Ren, A.	Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition.	Nucleic Acids Res.	2021	49	7139	7153	
7ELS	34125892	Crystal structure of xanthine riboswitch with 8-azaxanthine	2021-04-12	2021-06-30	Xu, X.,Egger, M.,Chen, H.,Bartosik, K.,Micura, R.,Ren, A.	Insights into xanthine riboswitch structure and metal ion-mediated ligand recognition.	Nucleic Acids Res.	2021	49	7139	7153	
7CGF	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGG	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGH	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGI	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGJ	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGK	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGL	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGM	34478557	Crystal Structure of PUF-8 in Complex with PBE-RNA	2020-07-01	2021-07-07	Xu, Z.,Zhao, J.,Hong, M.,Zeng, C.,Guang, S.,Shi, Y.	Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.	Nucleic Acids Res.	2021	49	10082	10097	
7CGZ		glucose dehydrogenase	2020-07-03	2021-07-07	Jia, S.,Xu, D.,Wang, W.,Ran, T.	Structure of glucose dehydrogenase at 1.33 Angstroms	To Be Published	0	0	0	0	
7CLD	34138737	Crystal structure of T2R-TTL-Cevipabulin complex	2020-07-20	2021-07-07	Yang, J.,Yu, Y.,Li, Y.,Yan, W.,Ye, H.,Niu, L.,Tang, M.,Wang, Z.,Yang, Z.,Pei, H.,Wei, H.,Zhao, M.,Wen, J.,Yang, L.,Ouyang, L.,Wei, Y.,Chen, Q.,Li, W.,Chen, L.	Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.	Sci Adv	2021	7	0	0	
7D0O	34259319	Crystal structure of human HBO1-BRPF2 in apo form	2020-09-11	2021-07-07	Xiao, Y.,Li, W.,Yang, H.,Pan, L.,Zhang, L.,Lu, L.,Chen, J.,Wei, W.,Ye, J.,Li, J.,Li, G.,Zhang, Y.,Tan, M.,Ding, J.,Wong, J.	HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.	Nucleic Acids Res.	2021	49	8037	8059	
7D0P	34259319	Crystal structure of human HBO1-BRPF2 in complex with propionyl-coenzyme A	2020-09-11	2021-07-07	Xiao, Y.,Li, W.,Yang, H.,Pan, L.,Zhang, L.,Lu, L.,Chen, J.,Wei, W.,Ye, J.,Li, J.,Li, G.,Zhang, Y.,Tan, M.,Ding, J.,Wong, J.	HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.	Nucleic Acids Res.	2021	49	8037	8059	
7D0Q	34259319	Crystal structure of human HBO1-BRPF2 in complex with butyryl-coenzyme A	2020-09-11	2021-07-07	Xiao, Y.,Li, W.,Yang, H.,Pan, L.,Zhang, L.,Lu, L.,Chen, J.,Wei, W.,Ye, J.,Li, J.,Li, G.,Zhang, Y.,Tan, M.,Ding, J.,Wong, J.	HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.	Nucleic Acids Res.	2021	49	8037	8059	
7DP8	34138737	Crystal structure of T2R-TTL-Cevipabulin-eribulin complex	2020-12-18	2021-07-07	Yang, J.,Yu, Y.,Li, Y.,Yan, W.,Ye, H.,Niu, L.,Tang, M.,Wang, Z.,Yang, Z.,Pei, H.,Wei, H.,Zhao, M.,Wen, J.,Yang, L.,Ouyang, L.,Wei, Y.,Chen, Q.,Li, W.,Chen, L.	Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.	Sci Adv	2021	7	0	0	
7DUS		Crystal structure of Mei2-RRM3 domain in S.pombe	2021-01-11	2021-07-07	Wu, B.X.,Xu, J.H.,Ma, J.B.	Crystal structure of Mei2-RRM3 domain in S.pombe	To Be Published	0	0	0	0	
7E4Q	34144258	Crystal structure of tubulin in complex with L-DM1-SMe	2021-02-14	2021-07-07	Li, W.,Huang, M.,Li, Y.,Xia, A.,Tan, L.,Zhang, Z.,Wang, Y.,Yang, J.	C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.	Biochem.Biophys.Res.Commun.	2021	566	197	203	
7E4R	34144258	Crystal structure of tubulin in complex with D-DM1-SMe	2021-02-15	2021-07-07	Li, W.,Huang, M.,Li, Y.,Xia, A.,Tan, L.,Zhang, Z.,Wang, Y.,Yang, J.	C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.	Biochem.Biophys.Res.Commun.	2021	566	197	203	
7E4Z	34144258	Crystal structure of tubulin in complex with Maytansinol	2021-02-16	2021-07-07	Li, W.,Huang, M.,Li, Y.,Xia, A.,Tan, L.,Zhang, Z.,Wang, Y.,Yang, J.	C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.	Biochem.Biophys.Res.Commun.	2021	566	197	203	
7OTJ	34166917	Crystal structure of Pif1 helicase from Candida albicans	2021-06-10	2021-07-07	Lu, K.Y.,Xin, B.G.,Zhang, T.,Liu, N.N.,Li, D.,Rety, S.,Xi, X.G.	Structural study of the function of Candida Albicans Pif1.	Biochem.Biophys.Res.Commun.	2021	567	190	194	
7CHV	34386329	Metallo-Beta-Lactamase VIM-2 in complex with 1-benzyl-1H-imidazole-2-carboxylic acid	2020-07-06	2021-07-14	Dai, Q.,Yan, Y.,Ning, X.,Li, G.,Yu, J.,Deng, J.,Yang, L.,Li, G.B.	AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-beta-lactamases and indoleamine/tryptophan 2,3-dioxygenases.	Acta Pharm Sin B	2021	11	1931	1946	
7CI0	35069500	Microbial Hormone-sensitive lipase E53 mutant S162A	2020-07-06	2021-07-14	Ding, Y.,Nie, L.,Yang, X.C.,Li, Y.,Huo, Y.Y.,Li, Z.,Gao, Y.,Cui, H.L.,Li, J.,Xu, X.W.	Mechanism and Structural Insights Into a Novel Esterase, E53, Isolated From Erythrobacter longus .	Front Microbiol	2021	12	798194	798194	
7CIH	35069500	Microbial Hormone-sensitive lipase E53 mutant S285G	2020-07-07	2021-07-14	Ding, Y.,Nie, L.,Yang, X.C.,Li, Y.,Huo, Y.Y.,Li, Z.,Gao, Y.,Cui, H.L.,Li, J.,Xu, X.W.	Mechanism and Structural Insights Into a Novel Esterase, E53, Isolated From Erythrobacter longus .	Front Microbiol	2021	12	798194	798194	
7CJL	35520685	Metallo-Beta-Lactamase VIM-2 in complex with (S)-N-(3-(2H-tetrazol-5-yl)phenyl)-3-mercapto-2-methylpropanamide	2020-07-11	2021-07-14	Yan, Y.H.,Chen, J.,Zhan, Z.,Yu, Z.J.,Li, G.,Guo, L.,Li, G.B.,Wu, Y.,Zheng, Y.	Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-beta-lactamase inhibitors.	Rsc Adv	2020	10	31377	31384	
7CZD	34172514	Crystal structure of PD-L1 in complex with a VHH	2020-09-08	2021-07-14	Zhai, T.,Wang, C.,Xu, Y.,Huang, W.,Yuan, Z.,Wang, T.,Dai, S.,Peng, S.,Pang, T.,Jiang, W.,Huang, Y.,Zou, Y.,Xu, Y.,Sun, J.,Gong, X.,Zhang, J.,Tsun, A.,Li, B.,Miao, X.	Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.	J Immunother Cancer	2021	9	0	0	
7DTL	34196616	Crystal structure of PSK, an antimicrobial peptide from Chrysomya megacephala	2021-01-05	2021-07-14	Xiao, C.,Xiao, Z.,Hu, C.,Lu, J.,Cui, L.,Zhang, Y.,Dai, Y.,Zhang, Q.,Wang, S.,Liu, W.	Crystal and solution structures of a novel antimicrobial peptide from Chrysomya megacephala.	Acta Crystallogr D Struct Biol	2021	77	894	903	
7EH0	34187896	Thermus thermophilus RNA polymerase transcription initiation complex containing a template-strand purine at position TSS-2, UpA RNA primer and CMPcPP	2021-03-27	2021-07-14	Skalenko, K.S.,Li, L.,Zhang, Y.,Vvedenskaya, I.O.,Winkelman, J.T.,Cope, A.L.,Taylor, D.M.,Shah, P.,Ebright, R.H.,Kinney, J.B.,Zhang, Y.,Nickels, B.E.	Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli .	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7EP2	34214466	Crystal structure of ZYG11B bound to GGFN degron	2021-04-26	2021-07-14	Yan, X.,Li, Y.,Wang, G.,Zhou, Z.,Song, G.,Feng, Q.,Zhao, Y.,Mi, W.,Ma, Z.,Dong, C.	Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 .	Mol.Cell	2021	81	3262	0	
7CLI	36779700	Structure of NF-kB p52 homodimer bound to P-Selectin kB DNA fragment	2020-07-21	2021-07-21	Pan, W.,Meshcheryakov, V.A.,Li, T.,Wang, Y.,Ghosh, G.,Wang, V.Y.	Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation.	Elife	2023	12	0	0	
7DXM		Crystal structure of DltD	2021-01-19	2021-07-21	Zeng, Q.,Tian, L.F.,Liu, Y.P.,Yan, X.X.,Xu, W.Q.	Crystal Structure of an O-acyltransfer Terminal Protein stDltD and Its Implications for dlt Operon-mediated D-alanylation of S. thermophilus.	Prog.Biochem.Biophys.	2022	48	1052	1062	
7E0O	34110158	Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 6-Bromo-1H-indazol-4-amine (1)	2021-01-28	2021-07-21	Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B.	X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.	J.Med.Chem.	2021	64	8303	8332	
7E0P	34110158	Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 4-(((6-Bromo-1H-indazol-4-yl)amino)methyl)phenol (2)	2021-01-28	2021-07-21	Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B.	X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.	J.Med.Chem.	2021	64	8303	8332	
7E0Q	34110158	Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with (1S,2R)-2-(((6-Bromo-1H-indazol-4-yl)amino)methyl)cyclohexan-1-ol (22)	2021-01-28	2021-07-21	Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B.	X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.	J.Med.Chem.	2021	64	8303	8332	
7E0S	34110158	Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with (1R,2S)-2-(((6-Bromo-1H-indazol-4-yl)amino)methyl)cyclohexan-1-ol (23)	2021-01-28	2021-07-21	Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B.	X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.	J.Med.Chem.	2021	64	8303	8332	
7E0T	34110158	Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with (1R,2S)-2-(((5-bromo-1H-indazol-4-yl)amino)methyl)Cyclohexan-1-ol (36)	2021-01-28	2021-07-21	Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B.	X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.	J.Med.Chem.	2021	64	8303	8332	
7E0U	34110158	Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 6-Bromo-N-(((1S,2S)-2-chlorocyclohexyl)methyl)-1H-indazol-4-amine (39)	2021-01-28	2021-07-21	Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B.	X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.	J.Med.Chem.	2021	64	8303	8332	
7FA3	34756887	Selenomethionine-derived structure of Aca1 in Pseudomonas phage JBD30	2021-07-05	2021-07-21	Liu, Y.,Zhang, L.,Guo, M.,Chen, L.,Wu, B.,Huang, H.	Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.	J.Biol.Chem.	2021	297	101357	101357	
7FAY	35477751	Crystal structure of SARS-CoV-2 main protease in complex with (R)-1a	2021-07-08	2021-07-21	Quan, B.X.,Shuai, H.,Xia, A.J.,Hou, Y.,Zeng, R.,Liu, X.L.,Lin, G.F.,Qiao, J.X.,Li, W.P.,Wang, F.L.,Wang, K.,Zhou, R.J.,Yuen, T.T.,Chen, M.X.,Yoon, C.,Wu, M.,Zhang, S.Y.,Huang, C.,Wang, Y.F.,Yang, W.,Tian, C.,Li, W.M.,Wei, Y.Q.,Yuen, K.Y.,Chan, J.F.,Lei, J.,Chu, H.,Yang, S.	An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.	Nat Microbiol	2022	7	716	725	
7FAZ	35477751	Crystal structure of the SARS-CoV-2 main protease in complex with Y180	2021-07-08	2021-07-21	Quan, B.X.,Shuai, H.,Xia, A.J.,Hou, Y.,Zeng, R.,Liu, X.L.,Lin, G.F.,Qiao, J.X.,Li, W.P.,Wang, F.L.,Wang, K.,Zhou, R.J.,Yuen, T.T.,Chen, M.X.,Yoon, C.,Wu, M.,Zhang, S.Y.,Huang, C.,Wang, Y.F.,Yang, W.,Tian, C.,Li, W.M.,Wei, Y.Q.,Yuen, K.Y.,Chan, J.F.,Lei, J.,Chu, H.,Yang, S.	An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.	Nat Microbiol	2022	7	716	725	
7E9B	34972111	Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy	2021-03-04	2021-07-28	Issafras, H.,Fan, S.,Tseng, C.L.,Cheng, Y.,Lin, P.,Xiao, L.,Huang, Y.J.,Tu, C.H.,Hsiao, Y.C.,Li, M.,Chen, Y.H.,Ho, C.H.,Li, O.,Wang, Y.,Chen, S.,Ji, Z.,Zhang, E.,Mao, Y.T.,Liu, E.,Yang, S.,Jiang, W.	Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy.	Plos One	2021	16	0	0	
7EKJ	34365500	Crystals structure of classical swine fever virus NS5B (residues 91-694)	2021-04-05	2021-07-28	Zhang, B.Y.,Liu, W.,Jia, H.,Lu, G.,Gong, P.	An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase.	Nucleic Acids Res.	2021	49	8811	8821	
7CNM	33220079	YDX in complex with tubulin	2020-08-02	2021-08-04	Chengyong, W.,Jinghong, X.,Yanyan, W.,Qing-Jie, X.,Lingling, M.,Yuyan, L.,Hai, C.,Qian, L.,Quan, Z.,Bo, S.,Yuxi, W.	The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.	Febs Lett.	2021	595	195	205	
7CNN	33220079	vinorelbine in complex with tubulin	2020-08-02	2021-08-04	Chengyong, W.,Jinghong, X.,Yanyan, W.,Qing-Jie, X.,Lingling, M.,Yuyan, L.,Hai, C.,Qian, L.,Quan, Z.,Bo, S.,Yuxi, W.	The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.	Febs Lett.	2021	595	195	205	
7D6C	33928692	Crystal structure of CcmM N-terminal domain in complex with CcmN	2020-09-30	2021-08-04	Sun, H.,Cui, N.,Han, S.J.,Chen, Z.P.,Xia, L.Y.,Chen, Y.,Jiang, Y.L.,Zhou, C.Z.	Complex structure reveals CcmM and CcmN form a heterotrimeric adaptor in beta-carboxysome.	Protein Sci.	2021	30	1566	1576	
7E9A	34259249	Crystal structure of KPC-2 in complex with (S)-2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acrylic acid (4a-(S))	2021-03-03	2021-08-04	Xiao, Y.C.,Chen, X.P.,Deng, J.,Yan, Y.H.,Zhu, K.R.,Li, G.,Yu, J.L.,Brem, J.,Chen, F.,Schofield, C.J.,Li, G.B.	Design and enantioselective synthesis of 3-( alpha-acrylic acid) benzoxaboroles to combat carbapenemase resistance.	Chem.Commun.(Camb.)	2021	57	7709	7712	
7CQM		PlsY grown in LCP soaked with selenourea for 22 min	2020-08-11	2021-08-11	Luo, Z.P.,Gu, W.,Wang, Y.,Tang, Y.,Li, D.F.	Selenourea for experimental phasing of membrane protein crystals grown in lipid cubic phase	Crystals	2022	12	0	0	
7EDO	34535575	First insight into marsupial MHC I peptide presentation: immune features of lower mammals paralleled with bats	2021-03-16	2021-08-11	Wang, P.,Yue, C.,Liu, K.,Lu, D.,Liu, S.,Yao, S.,Li, X.,Su, X.,Ren, K.,Chai, Y.,Qi, J.,Zhao, Y.,Lou, Y.,Sun, Z.,Gao, G.F.,Liu, W.J.	Peptide Presentations of Marsupial MHC Class I Visualize Immune Features of Lower Mammals Paralleled with Bats.	J Immunol.	2021	207	2167	2178	
7EIV	34390350	heterotetrameric glycyl-tRNA synthetase from Escherichia coli	2021-03-31	2021-08-11	Ju, Y.,Han, L.,Chen, B.,Luo, Z.,Gu, Q.,Xu, J.,Yang, X.L.,Schimmel, P.,Zhou, H.	X-shaped structure of bacterial heterotetrameric tRNA synthetase suggests cryptic prokaryote functions and a rationale for synthetase classifications.	Nucleic Acids Res.	2021	49	10106	10119	
7D88	34156819	Crystal structure of a novel thermostable GH10 xylanase XynA	2020-10-07	2021-08-18	Xie, W.,Yu, Q.,Zhang, R.,Liu, Y.,Cao, R.,Wang, S.,Zhan, R.,Liu, Z.,Wang, K.,Wang, C.	Insights into the Catalytic Mechanism of a Novel XynA and Structure-Based Engineering for Improving Bifunctional Activities.	Biochemistry	2021	60	2071	2083	
7D89	34156819	Crystal structure of an inactivated double mutant (E182AE280A) of a novel thermostable GH10 xylanase XynA	2020-10-07	2021-08-18	Xie, W.,Yu, Q.,Zhang, R.,Liu, Y.,Cao, R.,Wang, S.,Zhan, R.,Liu, Z.,Wang, K.,Wang, C.	Insights into the Catalytic Mechanism of a Novel XynA and Structure-Based Engineering for Improving Bifunctional Activities.	Biochemistry	2021	60	2071	2083	
7D8M	34059116	Crystal structure of DyP	2020-10-08	2021-08-18	Li, L.,Wang, T.,Chen, T.,Huang, W.,Zhang, Y.,Jia, R.,He, C.	Revealing two important tryptophan residues with completely different roles in a dye-decolorizing peroxidase from Irpex lacteus F17.	Biotechnol Biofuels	2021	14	128	128	
7EGN		Crystal structure of the P450 BM3 heme domain mutant F87A in complex with N-imidazolyl-hexanoyl-L-phenylalanine and hydroxylamine	2021-03-24	2021-08-18	Zhang, X.,Jiang, Y.,Chen, Q.,Dong, S.,Feng, Y.,Cong, Z.,Shaik, S.,Wang, B.	H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450	Acs Catalysis	2021	11	8774	8785	
7F9M	34433057	Crystal structure of the variable region of Plasmodium RIFIN #4 (PF3D7_1000500) in complex with LAIR1 (with T67L, N69S and A77T mutations)	2021-07-04	2021-08-18	Xie, Y.,Li, X.,Chai, Y.,Song, H.,Qi, J.,Gao, G.F.	Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1.	Cell Rep	2021	36	109600	109600	
7CUH	35849625	Crystal structure of fission yeast Pot1 and ssDNA	2020-08-23	2021-08-25	Sun, H.,Wu, Z.,Zhou, Y.,Lu, Y.,Lu, H.,Chen, H.,Shi, S.,Zeng, Z.,Wu, J.,Lei, M.	Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex.	Plos Genet.	2022	18	0	0	
7CUI	35849625	Crystal structure of fission yeast Pot1 and Tpz1	2020-08-23	2021-08-25	Sun, H.,Wu, Z.,Zhou, Y.,Lu, Y.,Lu, H.,Chen, H.,Shi, S.,Zeng, Z.,Wu, J.,Lei, M.	Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex.	Plos Genet.	2022	18	0	0	
7CUJ	35849625	Crystal structure of fission yeast Ccq1 and Tpz1	2020-08-23	2021-08-25	Sun, H.,Wu, Z.,Zhou, Y.,Lu, Y.,Lu, H.,Chen, H.,Shi, S.,Zeng, Z.,Wu, J.,Lei, M.	Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex.	Plos Genet.	2022	18	0	0	
7CUV	35966606	Crystal structure of a novel alpha/beta hydrolase in apo form	2020-08-25	2021-08-25	Pfaff, L.,Gao, J.,Li, Z.,Jackering, A.,Weber, G.,Mican, J.,Chen, Y.,Dong, W.,Han, X.,Feiler, C.G.,Ao, Y.F.,Badenhorst, C.P.S.,Bednar, D.,Palm, G.J.,Lammers, M.,Damborsky, J.,Strodel, B.,Liu, W.,Bornscheuer, U.T.,Wei, R.	Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase.	Acs Catalysis	2022	12	9790	9800	
7CUX		Crystal structure of human Schlafen 5 N'-terminal domain (SLFN5-N) involved in ssRNA cleaving and DNA binding	2020-08-25	2021-08-25	Yang, J.Y.,Luo, M.,Ou, J.Y.,Wang, Z.W.,Gao, S.	Crystal structure of human Schlafen 5 N'-terminal domain (SLFN5-N) involved in ssRNA cleaving and DNA binding	To Be Published	0	0	0	0	
7D9P	33570950	Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 12	2020-10-14	2021-08-25	Zhou, Y.,Fu, Y.,Yin, W.,Li, J.,Wang, W.,Bai, F.,Xu, S.,Gong, Q.,Peng, T.,Hong, Y.,Zhang, D.,Zhang, D.,Liu, Q.,Xu, Y.,Xu, H.E.,Zhang, H.,Jiang, H.,Liu, H.	Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.	J.Med.Chem.	2021	64	1844	1855	
7DE7	33937240	Crystal structure of PDZD7 HHD domain	2020-11-02	2021-08-25	Lin, L.,Wang, H.,Ren, D.,Xia, Y.,He, G.,Lu, Q.	Structure and Membrane Targeting of the PDZD7 Harmonin Homology Domain (HHD) Associated With Hearing Loss.	Front Cell Dev Biol	2021	9	642666	642666	
7DRV	34139177	Structural basis of SARS-CoV-2-closely-related bat coronavirus RaTG13 to hACE2	2020-12-29	2021-08-25	Liu, K.,Pan, X.,Li, L.,Yu, F.,Zheng, A.,Du, P.,Han, P.,Meng, Y.,Zhang, Y.,Wu, L.,Chen, Q.,Song, C.,Jia, Y.,Niu, S.,Lu, D.,Qiao, C.,Chen, Z.,Ma, D.,Ma, X.,Tan, S.,Zhao, X.,Qi, J.,Gao, G.F.,Wang, Q.	Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species.	Cell	2021	184	3438	0	
7E2S	34382282	Synechocystis GUN4 in complex with biliverdin IXa	2021-02-07	2021-08-25	Hu, J.H.,Chang, J.W.,Xu, T.,Wang, J.,Wang, X.,Lin, R.,Duanmu, D.,Liu, L.	Structural basis of bilin binding by the chlorophyll biosynthesis regulator GUN4.	Protein Sci.	2021	30	2083	2091	
7E2T	34382282	Synechocystis GUN4 in complex with phycocyanobilin	2021-02-07	2021-08-25	Hu, J.H.,Chang, J.W.,Xu, T.,Wang, J.,Wang, X.,Lin, R.,Duanmu, D.,Liu, L.	Structural basis of bilin binding by the chlorophyll biosynthesis regulator GUN4.	Protein Sci.	2021	30	2083	2091	
7E2U	34382282	Synechocystis GUN4 in complex with phytochrome	2021-02-07	2021-08-25	Hu, J.H.,Chang, J.W.,Xu, T.,Wang, J.,Wang, X.,Lin, R.,Duanmu, D.,Liu, L.	Structural basis of bilin binding by the chlorophyll biosynthesis regulator GUN4.	Protein Sci.	2021	30	2083	2091	
7EU2	34506741	Complex structure of HLA0201 with recognizing SARS-CoV-2 epitope S1	2021-05-15	2021-08-25	Zhang, H.,Deng, S.,Ren, L.,Zheng, P.,Hu, X.,Jin, T.,Tan, X.	Profiling CD8 + T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants.	Cell Rep	2021	36	109708	109708	
7CV6		RNA methyltransferase METTL4	2020-08-25	2021-09-01	Luo, Q.,Mo, J.,Chen, H.,Hu, Z.,Wang, B.,Wu, J.,Liang, Z.,Xie, W.,Du, K.,Peng, M.,Li, Y.,Li, T.,Zhang, Y.,Shi, X.,Shen, W.H.,Shi, Y.,Dong, A.,Wang, H.,Ma, J.	Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4	Nat Commun	2022	13	5636	0	
7CV7		RNA methyltransferase METTL4	2020-08-25	2021-09-01	Luo, Q.,Mo, J.,Chen, H.,Hu, Z.,Wang, B.,Wu, J.,Liang, Z.,Xie, W.,Du, K.,Peng, M.,Li, Y.,Li, T.,Zhang, Y.,Shi, X.,Shen, W.H.,Shi, Y.,Dong, A.,Wang, H.,Ma, J.	Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4	Nat Commun	2022	13	5636	0	
7CV8		RNA methyltransferase METTL4	2020-08-25	2021-09-01	Luo, Q.,Mo, J.,Chen, H.,Hu, Z.,Wang, B.,Wu, J.,Liang, Z.,Xie, W.,Du, K.,Peng, M.,Li, Y.,Li, T.,Zhang, Y.,Shi, X.,Shen, W.H.,Shi, Y.,Dong, A.,Wang, H.,Ma, J.	Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4	Nat Commun	2022	13	5636	0	
7CVA		RNA methyltransferase METTL4	2020-08-25	2021-09-01	Luo, Q.,Mo, J.,Chen, H.,Hu, Z.,Wang, B.,Wu, J.,Liang, Z.,Xie, W.,Du, K.,Peng, M.,Li, Y.,Li, T.,Zhang, Y.,Shi, X.,Shen, W.H.,Shi, Y.,Dong, A.,Wang, H.,Ma, J.	Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4	Nat Commun	2022	13	5636	0	
7DBE		Structure of a novel transaminase	2020-10-20	2021-09-01	Li, F.L.,Liang, Y.X.,Wei, Y.W.,Zheng, Y.K.,Yu, H.M.	Biochemical and Structural Characterization of an (R)-Selective Transaminase in the Asymmetric Synthesis of Chiral Hydroxy Amines.	Adv.Synth.Catal.	2021	0	0	0	
7EYI	34592153	Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation	2021-05-31	2021-09-01	Yang, Y.,Ren, R.,Ly, L.C.,Horton, J.R.,Li, F.,Quinlan, K.G.R.,Crossley, M.,Shi, Y.,Cheng, X.	Structural basis for human ZBTB7A action at the fetal globin promoter.	Cell Rep	2021	36	109759	109759	
7CZJ		The Crystal Structure of Family 20 CBM of Maltotetraose-forming Amylase from Pseudomonas Saccharophila STB07	2020-09-08	2021-09-08	Zhang, Z.Q.,Ban, X.F.,Li, C.M.,Gu, Z.B.,Hong, Y.,Cheng, L.,Li, Z.F.	The Crystal Structure of Family 20 CBM of Maltotetraose-forming Amylase from Pseudomonas Saccharophila STB07	To Be Published	0	0	0	0	
7DDX	34274317	Crystal structure of KANK1 S1179F mutant in complex wtih eIF4A1	2020-10-30	2021-09-08	Xu, Y.,Guo, C.,Pan, W.,Zhao, C.,Ding, Y.,Xie, X.,Wei, Z.,Sun, Y.,Yu, C.	Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.	J.Biol.Chem.	2021	297	100958	100958	
7BYI		Structure of SHMT2 in complex with CBX	2020-04-23	2021-09-15	Li, L.,Su, D.	Structure of SHMT2 with CBX	To Be Published	0	0	0	0	
7CWW		Crystal structure of TsrL	2020-08-31	2021-09-15	Li, Y.,Pan, L.F.	crystal structure of TsrL	To Be Published	0	0	0	0	
7CYI		Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua	2020-09-03	2021-09-15	Yang, Z.	Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua	To Be Published	0	0	0	0	
7DJS		Crystal structure of isopiperitenol dehydrogenase from Pseudomonas aeruginosa complexed with NAD	2020-11-21	2021-09-15	Zhan, J.R.,Shou, C.,Zheng, Y.C.,Chen, Q.,Pan, J.,Li, C.X.,Xu, J.H.	Discovery and Engineering of Bacterial (-)-Isopiperitenol Dehydrogenases to Enhance (-)-Menthol Precursor Biosynthesis.	Adv.Synth.Catal.	2021	363	3973	3982	
7E3O	34643438	Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody nCoV617	2021-02-09	2021-09-15	Yang, M.,Li, J.,Huang, Z.,Li, H.,Wang, Y.,Wang, X.,Kang, S.,Huang, X.,Wu, C.,Liu, T.,Jia, Z.,Liang, J.,Yuan, X.,He, S.,Chen, X.,Zhou, Z.,Chen, Q.,Liu, S.,Li, J.,Zheng, H.,Liu, X.,Li, K.,Yao, X.,Lang, B.,Liu, L.,Liao, H.X.,Chen, S.	Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.	Microbiol Spectr	2021	9	0	0	
7ET4	34446554	Crystal structure of Arabidopsis TEM1 AP2 domain	2021-05-12	2021-09-15	Hu, H.,Tian, S.,Xie, G.,Liu, R.,Wang, N.,Li, S.,He, Y.,Du, J.	TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7ET5	34446554	Crystal structure of Arabidopsis TEM1 AP2 domain	2021-05-12	2021-09-15	Hu, H.,Tian, S.,Xie, G.,Liu, R.,Wang, N.,Li, S.,He, Y.,Du, J.	TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7ET6	34446554	Crystal structure of Arabidopsis TEM1 B3-DNA complex	2021-05-12	2021-09-15	Hu, H.,Tian, S.,Xie, G.,Liu, R.,Wang, N.,Li, S.,He, Y.,Du, J.	TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
6X1C	34406768	Tubulin-RB3_SLD-TTL in complex with compound 5j	2020-05-18	2021-09-22	Banerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D.	X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.	J.Med.Chem.	2021	64	13072	13095	
6X1E	34406768	Tubulin-RB3_SLD-TTL in complex with compound 5l	2020-05-18	2021-09-22	Banerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D.	X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.	J.Med.Chem.	2021	64	13072	13095	
6X1F	34406768	Tubulin-RB3_SLD-TTL in complex with compound 5m	2020-05-18	2021-09-22	Banerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D.	X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.	J.Med.Chem.	2021	64	13072	13095	
7D2W		Crystal structure of PHIT/PHISTa-like subfamily PF3D7_1372300 protein from plasmodium falciparum	2020-09-17	2021-09-22	Yang, B.L.,Gao, Y.	Structural analysis of binding between Plasmodium falciparum PHIST and the parasite virulence factor PfEMP1 protein	To Be Published	0	0	0	0	
7D32	35013452	The TBA-Pb2+ complex in P41212 space group	2020-09-18	2021-09-22	Liu, H.,Gao, Y.,Mathivanan, J.,Shen, F.,Chen, X.,Li, Y.,Shao, Z.,Zhang, Y.,Shao, Q.,Sheng, J.,Gan, J.	Structure-guided development of Pb 2+ -binding DNA aptamers.	Sci Rep	2022	12	460	460	
7DAI	33682300	The crystal structure of a serotonin N-acetyltransferase from Oryza Sativa	2020-10-16	2021-09-22	Liao, L.,Zhou, Y.,Xu, Y.,Zhang, Y.,Liu, X.,Liu, B.,Chen, X.,Guo, Y.,Zeng, Z.,Zhao, Y.	Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2021	60	12020	12026	
7DAJ	33682300	The crystal structure of serotonin N-acetyltransferase in complex with acetyl-CoA from Oryza Sativa	2020-10-16	2021-09-22	Liao, L.,Zhou, Y.,Xu, Y.,Zhang, Y.,Liu, X.,Liu, B.,Chen, X.,Guo, Y.,Zeng, Z.,Zhao, Y.	Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2021	60	12020	12026	
7DAK	33682300	The crystal structure of a serotonin N-acetyltransferase in complex with 5-Methoxytryptamine and acetyl-CoA from Oryza Sativa	2020-10-16	2021-09-22	Liao, L.,Zhou, Y.,Xu, Y.,Zhang, Y.,Liu, X.,Liu, B.,Chen, X.,Guo, Y.,Zeng, Z.,Zhao, Y.	Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2021	60	12020	12026	
7DAL	33682300	The crystal structure of a serotonin N-acetyltransferase in complex with serotonin and acetyl-CoA from Oryza Sativa	2020-10-16	2021-09-22	Liao, L.,Zhou, Y.,Xu, Y.,Zhang, Y.,Liu, X.,Liu, B.,Chen, X.,Guo, Y.,Zeng, Z.,Zhao, Y.	Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2021	60	12020	12026	
7E6G	34498587	Crystal structure of diguanylate cyclase SiaD in complex with its activator SiaC from Pseudomonas aeruginosa	2021-02-22	2021-09-22	Chen, G.,Zhou, J.,Zuo, Y.,Huo, W.,Peng, J.,Li, M.,Zhang, Y.,Wang, T.,Zhang, L.,Zhang, L.,Liang, H.	Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa .	Elife	2021	10	0	0	
7FC3	35917815	structure of NL63 receptor-binding domain complexed with horse ACE2	2021-07-13	2021-09-22	Lan, J.,Chen, P.,Liu, W.,Ren, W.,Zhang, L.,Ding, Q.,Zhang, Q.,Wang, X.,Ge, J.	Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2.	Structure	2022	30	1432	0	
7LZ7	34406768	Tubulin-RB3_SLD-TTL in complex with compound 5k	2021-03-09	2021-09-22	Banerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D.	X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.	J.Med.Chem.	2021	64	13072	13095	
7LZB	34671445	Crystal Structure of SETD2 bound to Compound 2	2021-03-09	2021-09-22	Lampe, J.W.,Alford, J.S.,Boriak-Sjodin, P.A.,Brach, D.,Cosmopoulos, K.,Duncan, K.W.,Eckley, S.T.,Foley, M.A.,Harvey, D.M.,Motwani, V.,Munchhof, M.J.,Raimondi, A.,Riera, T.V.,Tang, C.,Thomenius, M.J.,Totman, J.,Farrow, N.A.	Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.	Acs Med.Chem.Lett.	2021	12	1539	1545	
7LZD	34671445	Crystal Structure of SETD2 bound to Compound 35	2021-03-09	2021-09-22	Lampe, J.W.,Alford, J.S.,Boriak-Sjodin, P.A.,Brach, D.,Cosmopoulos, K.,Duncan, K.W.,Eckley, S.T.,Foley, M.A.,Harvey, D.M.,Motwani, V.,Munchhof, M.J.,Raimondi, A.,Riera, T.V.,Tang, C.,Thomenius, M.J.,Totman, J.,Farrow, N.A.	Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.	Acs Med.Chem.Lett.	2021	12	1539	1545	
7DBF	34477187	The structure of the Arabidopsis thaliana guanosine deaminase	2020-10-20	2021-09-29	Jia, Q.,Zeng, H.,Li, H.,Xiao, N.,Tang, J.,Gao, S.,Zhang, J.,Xie, W.	The C-terminal loop of Arabidopsis thaliana guanosine deaminase is essential to catalysis.	Chem.Commun.(Camb.)	2021	57	9748	9751	
7DC9	34477187	The structure of the Arabidopsis thaliana guanosine deaminase mutant E82Q complex with guanosine	2020-10-23	2021-09-29	Jia, Q.,Zeng, H.,Li, H.,Xiao, N.,Tang, J.,Gao, S.,Zhang, J.,Xie, W.	The C-terminal loop of Arabidopsis thaliana guanosine deaminase is essential to catalysis.	Chem.Commun.(Camb.)	2021	57	9748	9751	
7DL0	33624917	The mutant E310G/A314Y of 3,5-DAHDHcca complex with NADPH	2020-11-25	2021-09-29	Liu, N.,Wu, L.,Feng, J.,Sheng, X.,Li, J.,Chen, X.,Li, J.,Liu, W.,Zhou, J.,Wu, Q.,Zhu, D.	Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.	Angew.Chem.Int.Ed.Engl.	2021	60	10203	10210	
7DL3	33624917	The structure of 3,5-DAHDHcca complex with NADPH	2020-11-25	2021-09-29	Liu, N.,Wu, L.,Feng, J.,Sheng, X.,Li, J.,Chen, X.,Li, J.,Liu, W.,Zhou, J.,Wu, Q.,Zhu, D.	Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids.	Angew.Chem.Int.Ed.Engl.	2021	60	10203	10210	
7D3T	35332155	Crystal structure of OSPHR2 in complex with DNA	2020-09-20	2021-10-06	Guan, Z.,Zhang, Q.,Zhang, Z.,Zuo, J.,Chen, J.,Liu, R.,Savarin, J.,Broger, L.,Cheng, P.,Wang, Q.,Pei, K.,Zhang, D.,Zou, T.,Yan, J.,Yin, P.,Hothorn, M.,Liu, Z.	Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 - PHR2 complex.	Nat Commun	2022	13	1581	1581	
7DMK	33610038	PL6 alginate lyase BcAlyPL6	2020-12-04	2021-10-06	Wang, B.,Dong, S.,Li, F.L.,Ma, X.Q.	Structural basis for the exolytic activity of polysaccharide lyase family 6 alginate lyase BcAlyPL6 from human gut microbe Bacteroides clarus.	Biochem.Biophys.Res.Commun.	2021	547	111	117	
7E4O		Class I Pimarane-Type Diterpene Synthases from Actinomycetes	2021-02-14	2021-10-06	Xing, B.,Yu, J.,Chi, C.,Ma, X.,Xu, Q.,Li, A.,Ge, Y.,Wang, Z.,Liu, T.,Jia, H.,Yin, F.,Guo, J.,Huang, L.,Yang, D.,Ma, M.	Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis	Commun Chem	2021	4	140	0	
7EMG	34559867	Carbonyl Reductase Variant 4 (R123C/L209P/F183Y/V61K) from Serratia marcescens complexed with NADP+	2021-04-14	2021-10-06	Wang, T.,Zhang, X.Y.,Zheng, Y.C.,Bai, Y.P.	Stereoselective synthesis of chiral delta-lactones via an engineered carbonyl reductase.	Chem.Commun.(Camb.)	2021	57	10584	10587	
7E53	34098312	Crystal structure of sfGFP complexed with the nanobody nb2 at 2.2 Angstron resolution	2021-02-16	2021-10-13	Zhong, P.,Wang, Z.,Cheng, S.,Zhang, Y.,Jiang, H.,Liu, R.,Ding, Y.	Structural insights into two distinct nanobodies recognizing the same epitope of green fluorescent protein.	Biochem.Biophys.Res.Commun.	2021	565	57	63	
7ELG	34590387	LC3B modificated with a covalent probe	2021-04-10	2021-10-13	Fan, S.,Yue, L.,Wan, W.,Zhang, Y.,Zhang, B.,Otomo, C.,Li, Q.,Lin, T.,Hu, J.,Xu, P.,Zhu, M.,Tao, H.,Chen, Z.,Li, L.,Ding, H.,Yao, Z.,Lu, J.,Wen, Y.,Zhang, N.,Tan, M.,Chen, K.,Xie, Y.,Otomo, T.,Zhou, B.,Jiang, H.,Dang, Y.,Luo, C.	Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein.	Angew.Chem.Int.Ed.Engl.	2021	60	26105	26114	
7VJM	34756887	Aca1 in complex with 19bp palindromic DNA substrate	2021-09-28	2021-10-13	Liu, Y.,Zhang, L.,Guo, M.,Chen, L.,Wu, B.,Huang, H.	Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.	J.Biol.Chem.	2021	297	101357	101357	
7VJN	34756887	Crystal structure of anti-CRISPR-associated protein Aca1 in Pseudomonas phage JBD30	2021-09-28	2021-10-13	Liu, Y.,Zhang, L.,Guo, M.,Chen, L.,Wu, B.,Huang, H.	Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.	J.Biol.Chem.	2021	297	101357	101357	
7DA9		Structure of 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase (HspB) from Pseudomonas putida S16	2020-10-15	2021-10-20	Liu, G.Q.,Liu, G.Q.	Structure of 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase (HspB) from Pseudomonas putida S16	To Be Published	0	0	0	0	
7DB9		IC1 in complex with tubulin	2020-10-19	2021-10-20	Wu, C.Y.,Wang, Y.X.	IC1 in complex with tubulin	To Be Published	0	0	0	0	
7DBA		RYX in complex with tubulin	2020-10-19	2021-10-20	Wu, C.Y.,Wang, Y.X.	RYX in complex with tubulin	To Be Published	0	0	0	0	
7DBB		SSE in complex with tubulin	2020-10-19	2021-10-20	Wu, C.Y.,Wang, Y.X.	SSE in complex with tubulin	To Be Published	0	0	0	0	
7DBC		PRA in complex with tubulin	2020-10-19	2021-10-20	Wu, C.Y.,Wang, Y.X.	PRA in complex with tubulin	To Be Published	0	0	0	0	
7DBD		444 in complex with tubulin	2020-10-19	2021-10-20	Wu, C.Y.,Wang, Y.X.	444 in complex with tubulin	To Be Published	0	0	0	0	
7DMY	33548625	The crystal structure of Cpd7 in complex with BPTF bromodomain	2020-12-08	2021-10-20	Xiong, L.,Mao, X.,Guo, Y.,Zhou, Y.,Chen, M.,Chen, P.,Yang, S.,Li, L.	Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization.	Biochem.Biophys.Res.Commun.	2021	545	125	131	
7DN4	33548625	The crystal structure of Cpd8 in complex with BPTF bromodomain	2020-12-08	2021-10-20	Xiong, L.,Mao, X.,Guo, Y.,Zhou, Y.,Chen, M.,Chen, P.,Yang, S.,Li, L.	Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization.	Biochem.Biophys.Res.Commun.	2021	545	125	131	
7EVR	34750379	Crystal structure of hnRNP L RRM2 in complex with SETD2	2021-05-22	2021-10-20	Bhattacharya, S.,Wang, S.,Reddy, D.,Shen, S.,Zhang, Y.,Zhang, N.,Li, H.,Washburn, M.P.,Florens, L.,Shi, Y.,Workman, J.L.,Li, F.	Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing.	Nat Commun	2021	12	6452	6452	
7EVS	34750379	Crystal structure of hnRNP LL RRM2 in complex with SETD2	2021-05-22	2021-10-20	Bhattacharya, S.,Wang, S.,Reddy, D.,Shen, S.,Zhang, Y.,Zhang, N.,Li, H.,Washburn, M.P.,Florens, L.,Shi, Y.,Workman, J.L.,Li, F.	Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing.	Nat Commun	2021	12	6452	6452	
7VJO	34756887	Pectobacterium phage ZF40 apo-Aca2	2021-09-28	2021-10-20	Liu, Y.,Zhang, L.,Guo, M.,Chen, L.,Wu, B.,Huang, H.	Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.	J.Biol.Chem.	2021	297	101357	101357	
7DLZ		Crystal Structure of Methyltransferase Ribozyme	2020-11-30	2021-10-27	Jiang, H.Y.,Gao, Y.Q.,Zhang, L.,Chen, D.R.,Gan, J.H.,Murchie, A.I.H.	The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences	Nat Catal	2021	4	872	881	
7DOR	34098257	E. coli GyrB ATPase domain in complex with 4-nitropheno	2020-12-16	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DPR	34098257	E. coli GyrB ATPase domain in complex with methyl 3,4-dihydroxybenzoate	2020-12-21	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DPS	34098257	E. coli GyrB ATPase domain in complex with Methyl 4-hydroxycinnamate	2020-12-21	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQF	34098257	E. coli GyrB ATPase domain in complex with methyl 2,4-dihydroxybenzoate	2020-12-23	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQH	34098257	E. coli GyrB ATPase domain in complex with 2-hydroxybenzamide	2020-12-23	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQI	34098257	E. coli GyrB ATPase domain in complex with Esculetin	2020-12-23	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQJ	34098257	E. coli GyrB ATPase domain in complex with 3,4-Dihydroxyacetophenone	2020-12-24	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQL	34098257	E. coli GyrB ATPase domain in complex with 4-chlorobenzene-1,2-diol	2020-12-24	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQM	34098257	E. coli GyrB ATPase domain in complex with Naringenin	2020-12-24	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQS	34098257	E. coli GyrB ATPase domain in complex with 2-chlorophenol	2020-12-24	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQU	34098257	E. coli GyrB ATPase domain in complex with methyl 4-hydroxybenzoate	2020-12-24	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7DQW	34098257	E. coli GyrB ATPase domain in complex with 4-chlorophenol	2020-12-24	2021-10-27	Yu, Y.,Guo, J.,Cai, Z.,Ju, Y.,Xu, J.,Gu, Q.,Zhou, H.	Identification of new building blocks by fragment screening for discovering GyrB inhibitors.	Bioorg.Chem.	2021	114	105040	105040	
7E1T	34793709	Crystal structure of Rab9A-GTP-Nde1	2021-02-03	2021-10-27	Zhang, Y.,Chen, Z.,Wang, F.,Sun, H.,Zhu, X.,Ding, J.,Zhang, T.	Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex.	Structure	2022	30	386	0	
7VNU	36806252	Crystal structure of the N-terminal domain of SARS-CoV-2 nucleocapsid protein	2021-10-12	2021-10-27	Ni, X.,Han, Y.,Zhou, R.,Zhou, Y.,Lei, J.	Structural insights into ribonucleoprotein dissociation by nucleocapsid protein interacting with non-structural protein 3 in SARS-CoV-2.	Commun Biol	2023	6	193	193	
7DAV		The native crystal structure of COVID-19 main protease	2020-10-18	2021-11-03	He, Z.,Ye, F.,Zhang, C.,Fan, J.,Du, Z.,Zhao, W.,Yuan, Q.,Niu, W.,Gao, F.,He, B.,Cao, P.,Zhao, L.,Gao, X.,Gao, X.,Sun, B.,Dong, Y.,Zhao, J.,Qi, J.,Liang, X.J.,Jiang, H.,Gong, Y.,Tan, W.,Gao, X.	A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster.	Nano Today	2022	44	101468	0	
7DW5	34699692	Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites	2021-01-15	2021-11-03	Zhang, H.,Cheng, N.,Li, Z.,Bai, L.,Fang, C.,Li, Y.,Zhang, W.,Dong, X.,Jiang, M.,Liang, Y.,Zhang, S.,Mi, J.,Zhu, J.,Zhang, Y.,Chen, S.J.,Zhao, Y.,Weng, X.Q.,Hu, W.,Chen, Z.,Huang, J.,Meng, G.	DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.	Cancer Commun (Lond)	2021	41	1116	1136	
7VH8	34687004	Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	2021-09-21	2021-11-03	Zhao, Y.,Fang, C.,Zhang, Q.,Zhang, R.,Zhao, X.,Duan, Y.,Wang, H.,Zhu, Y.,Feng, L.,Zhao, J.,Shao, M.,Yang, X.,Zhang, L.,Peng, C.,Yang, K.,Ma, D.,Rao, Z.,Yang, H.	Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.	Protein Cell	2022	13	689	693	
7DE0		Crystal structure of FtmOx1 Y224F mutation	2020-10-31	2021-11-10	Wang, F.,Gao, Y.Q.,Wang, C.X.,Lan, W.X.,Gan, J.H.,Cao, C.Y.	Structure-based Insights into Mechanism of Endoperoxidase FtmOx1 Catalyzed Reactions	Catalysis Science And Technolo	2023	0	0	0	
7DE3		Human adenylate kinase 1 (hAK1) mutant-R128W	2020-11-01	2021-11-10	Lin, W.	Structure of human adenylate kinase 1 mutant-R128W.	To Be Published	0	0	0	0	
7ESX	34620712	Crystal structure of Wolbachia cytoplasmic incompatibility factor CidA from wPip	2021-05-12	2021-11-10	Xiao, Y.,Chen, H.,Wang, H.,Zhang, M.,Chen, X.,Berk, J.M.,Zhang, L.,Wei, Y.,Li, W.,Cui, W.,Wang, F.,Wang, Q.,Cui, C.,Li, T.,Chen, C.,Ye, S.,Zhang, L.,Ji, X.,Huang, J.,Wang, W.,Wang, Z.,Hochstrasser, M.,Yang, H.	Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7VEM	35910145	the NADPH-assisted quinone oxidoreductase from Phytophthora capsici	2021-09-09	2021-11-10	Yang, C.,Huang, Z.,Zhang, X.,Zhu, C.	Structural Insights into the NAD(P)H:Quinone Oxidoreductase from Phytophthora capsici.	Acs Omega	2022	7	25705	25714	
7VEY	34777436	Crystal structure of Cyclosorus parasiticus chalcone synthase 1 (CpCHS1)	2021-09-10	2021-11-10	Niu, M.,Fu, J.,Ni, R.,Xiong, R.L.,Zhu, T.T.,Lou, H.X.,Zhang, P.,Li, J.,Cheng, A.X.	Functional and Structural Investigation of Chalcone Synthases Based on Integrated Metabolomics and Transcriptome Analysis on Flavonoids and Anthocyanins Biosynthesis of the Fern Cyclosorus parasiticus .	Front Plant Sci	2021	12	757516	757516	
7VEZ	34777436	Crystal structure of Cyclosorus parasiticus chalcone synthase 1 (CpCHS1) complex with naringenin	2021-09-10	2021-11-10	Niu, M.,Fu, J.,Ni, R.,Xiong, R.L.,Zhu, T.T.,Lou, H.X.,Zhang, P.,Li, J.,Cheng, A.X.	Functional and Structural Investigation of Chalcone Synthases Based on Integrated Metabolomics and Transcriptome Analysis on Flavonoids and Anthocyanins Biosynthesis of the Fern Cyclosorus parasiticus .	Front Plant Sci	2021	12	757516	757516	
7VF0	34777436	Crystal structure of Cyclosorus parasiticus chalcone synthase 1 (CpCHS1) complex with naringenin and CoA	2021-09-10	2021-11-10	Niu, M.,Fu, J.,Ni, R.,Xiong, R.L.,Zhu, T.T.,Lou, H.X.,Zhang, P.,Li, J.,Cheng, A.X.	Functional and Structural Investigation of Chalcone Synthases Based on Integrated Metabolomics and Transcriptome Analysis on Flavonoids and Anthocyanins Biosynthesis of the Fern Cyclosorus parasiticus .	Front Plant Sci	2021	12	757516	757516	
7D9G	34741591	SpdH Spermidine dehydrogenase native structure	2020-10-13	2021-11-17	Che, S.,Liang, Y.,Chen, Y.,Wu, W.,Liu, R.,Zhang, Q.,Bartlam, M.	Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold.	Febs J.	2022	289	1911	1928	
7D9H	34741591	SpdH Spermidine dehydrogenase N33 truncation structure	2020-10-13	2021-11-17	Che, S.,Liang, Y.,Chen, Y.,Wu, W.,Liu, R.,Zhang, Q.,Bartlam, M.	Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold.	Febs J.	2022	289	1911	1928	
7F3N	34645811	Structure of PopP2 in apo form	2021-06-16	2021-11-17	Xia, Y.,Zou, R.,Escouboue, M.,Zhong, L.,Zhu, C.,Pouzet, C.,Wu, X.,Wang, Y.,Lv, G.,Zhou, H.,Sun, P.,Ding, K.,Deslandes, L.,Yuan, S.,Zhang, Z.M.	Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase.	Nat Commun	2021	12	5969	5969	
7DGB	35635946	The co-crystal structure of SARS-CoV-2 main protease with (S)-2-cinnamamido-4-methyl-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)pentanamide	2020-11-11	2021-11-24	Wang, H.,Pei, R.,Li, X.,Deng, W.,Xing, S.,Zhang, Y.,Zhang, C.,He, S.,Sun, H.,Xiao, S.,Xiong, J.,Zhang, Y.,Chen, X.,Wang, Y.,Guo, Y.,Zhang, B.,Shang, L.	The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.	Eur.J.Med.Chem.	2022	238	114458	114458	
7DGG	35635946	The co-crystal structure of SARS-CoV-2 main protease with (S)-2-cinnamamido-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)hexanamide	2020-11-11	2021-11-24	Wang, H.,Pei, R.,Li, X.,Deng, W.,Xing, S.,Zhang, Y.,Zhang, C.,He, S.,Sun, H.,Xiao, S.,Xiong, J.,Zhang, Y.,Chen, X.,Wang, Y.,Guo, Y.,Zhang, B.,Shang, L.	The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.	Eur.J.Med.Chem.	2022	238	114458	114458	
7DGH	35635946	The co-crystal structure of SARS-CoV-2 main protease with peptidomimetic inhibitor N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopiperidin-3-yl)propan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-2-naphthamide	2020-11-11	2021-11-24	Wang, H.,Pei, R.,Li, X.,Deng, W.,Xing, S.,Zhang, Y.,Zhang, C.,He, S.,Sun, H.,Xiao, S.,Xiong, J.,Zhang, Y.,Chen, X.,Wang, Y.,Guo, Y.,Zhang, B.,Shang, L.	The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.	Eur.J.Med.Chem.	2022	238	114458	114458	
7DGI	35635946	The co-crystal structure of SARS-CoV-2 main protease with peptidomimetic inhibitor N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopiperidin-3-yl)propan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-4-nitrobenzamide	2020-11-11	2021-11-24	Wang, H.,Pei, R.,Li, X.,Deng, W.,Xing, S.,Zhang, Y.,Zhang, C.,He, S.,Sun, H.,Xiao, S.,Xiong, J.,Zhang, Y.,Chen, X.,Wang, Y.,Guo, Y.,Zhang, B.,Shang, L.	The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.	Eur.J.Med.Chem.	2022	238	114458	114458	
7DGW	35140398	De novo designed protein H4A2S	2020-11-12	2021-11-24	Huang, B.,Xu, Y.,Hu, X.,Liu, Y.,Liao, S.,Zhang, J.,Huang, C.,Hong, J.,Chen, Q.,Liu, H.	A backbone-centred energy function of neural networks for protein design.	Nature	2022	602	523	528	
7DHJ	35635946	The co-crystal structure of SARS-CoV-2 main protease with the peptidomimetic inhibitor (S)-2-cinnamamido-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)pent-4-ynamide	2020-11-15	2021-11-24	Wang, H.,Pei, R.,Li, X.,Deng, W.,Xing, S.,Zhang, Y.,Zhang, C.,He, S.,Sun, H.,Xiao, S.,Xiong, J.,Zhang, Y.,Chen, X.,Wang, Y.,Guo, Y.,Zhang, B.,Shang, L.	The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.	Eur.J.Med.Chem.	2022	238	114458	114458	
7DKH	34852272	Crystal structure of the Ctr9/Paf1/Cdc73/Rtf1 quaternary complex	2020-11-24	2021-11-24	Chen, F.L.,Liu, B.B.,Zeng, J.W.,Guo, L.,Ge, X.,Feng, W.,Li, D.F.,Zhou, H.,Long, J.F.	Crystal Structure of the Core Module of the Yeast Paf1 Complex.	J.Mol.Biol.	2021	434	167369	167369	
7EI1	33864868	Structure of Pyrococcus furiosus Cas1Cas2 complex	2021-03-30	2021-11-24	Tang, D.,Li, H.,Wu, C.,Jia, T.,He, H.,Yao, S.,Yu, Y.,Chen, Q.	A distinct structure of Cas1-Cas2 complex provides insights into the mechanism for the longer spacer acquisition in Pyrococcus furiosus.	Int.J.Biol.Macromol.	2021	183	379	386	
7EOG	34725509	Crystal structure of the Pepper aptamer in complex with HBC, iridium hexammine soak	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOH	34725509	Crystal structure of the Pepper aptamer in complex with HBC	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOI	34725509	Crystal structure of the Pepper aptamer in complex with HBC, manganese soak	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOJ	34725509	Crystal structure of the Pepper aptamer in complex with HBC, cesium soak	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOK	34725509	Crystal structure of the Pepper aptamer in complex with HBC485	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOL	34725509	Crystal structure of the Pepper aptamer in complex with HBC497	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOM	34725509	Crystal structure of the Pepper aptamer in complex with HBC508	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EON	34725509	Crystal structure of the Pepper aptamer in complex with HBC514	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOO	34725509	Crystal structure of the Pepper aptamer in complex with HBC525	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7EOP	34725509	Crystal structure of the Pepper aptamer in complex with HBC620	2021-04-22	2021-11-24	Huang, K.,Chen, X.,Li, C.,Song, Q.,Li, H.,Zhu, L.,Yang, Y.,Ren, A.	Structure-based investigation of fluorogenic Pepper aptamer.	Nat.Chem.Biol.	2021	17	1289	1295	
7DL4		Crystal structure of human serum albumin and nitrosylruthenium complex adduct	2020-11-26	2021-12-01	Xie, L.L.,Wang, W.M.,Wang, H.F.	Structural and Photodynamic Studies on Nitrosylruthenium Complexed Serum Albumin	To Be Published	0	0	0	0	
7DL5	35120932	Crystal structure of Thermotoga Maritima ferritin mutant at 2.3 Angstrom resolution	2020-11-26	2021-12-01	Liu, Y.,Zang, J.,Leng, X.,Zhao, G.	A short helix regulates conversion of dimeric and 24-meric ferritin architectures.	Int.J.Biol.Macromol.	2022	203	535	542	
7DLB		Crassostrea gigas ferritin mutant-D119K	2020-11-26	2021-12-01	Li, H.,Zang, J.,Wang, Z.,Du, M.	Crassostrea gigas ferritin mutant-D119K	To Be Published	0	0	0	0	
7DLH		Crystallization of Cationic Peroxidase from Proso Millet and Identification of Its Phosphatase Active Sites	2020-11-27	2021-12-01	Cui, x.d.,Wang, t.f.	Crystallization of Cationic Peroxidase from Proso Millet and Identification of Its Phosphatase Active Sites	To Be Published	0	0	0	0	
7DLV	34171258	shrimp dUTPase in complex with Stl	2020-11-30	2021-12-01	Wang, F.,Liu, C.,Wang, C.,Wang, Y.,Zang, K.,Wang, X.,Liu, X.,Li, S.,Li, F.,Ma, Q.	Structural basis of staphylococcal Stl inhibition on a eukaryotic dUTPase.	Int.J.Biol.Macromol.	2021	184	821	830	
7DQO		Marsupenaeus japonicus ferritin mutant-D132R	2020-12-24	2021-12-01	Tan, X.,Liu, Y.,Zang, J.,Zhang, T.,Zhao, G.	Hyperthermostability of prawn ferritin nanocage facilitates its application as a robust nanovehicle for nutraceuticals.	Int.J.Biol.Macromol.	2021	191	152	160	
7E1Q	34836944	Crystal structure of dehydrogenase/isomerase FabX from Helicobacter pylori	2021-02-03	2021-12-01	Zhou, J.,Zhang, L.,Zeng, L.,Yu, L.,Duan, Y.,Shen, S.,Hu, J.,Zhang, P.,Song, W.,Ruan, X.,Jiang, J.,Zhang, Y.,Zhou, L.,Jia, J.,Hang, X.,Tian, C.,Lin, H.,Chen, H.Z.,Cronan, J.E.,Bi, H.,Zhang, L.	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis.	Nat Commun	2021	12	6932	6932	
7E1R	34836944	Crystal structure of Dehydrogenase/isomerase FabX from Helicobacter pylori in complex with holo-ACP	2021-02-03	2021-12-01	Zhou, J.,Zhang, L.,Zeng, L.,Yu, L.,Duan, Y.,Shen, S.,Hu, J.,Zhang, P.,Song, W.,Ruan, X.,Jiang, J.,Zhang, Y.,Zhou, L.,Jia, J.,Hang, X.,Tian, C.,Lin, H.,Chen, H.Z.,Cronan, J.E.,Bi, H.,Zhang, L.	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis.	Nat Commun	2021	12	6932	6932	
7E1S	34836944	Crystal structure of dehydrogenase/isomerase FabX from Helicobacter pylori in complex with octanoyl-ACP	2021-02-03	2021-12-01	Zhou, J.,Zhang, L.,Zeng, L.,Yu, L.,Duan, Y.,Shen, S.,Hu, J.,Zhang, P.,Song, W.,Ruan, X.,Jiang, J.,Zhang, Y.,Zhou, L.,Jia, J.,Hang, X.,Tian, C.,Lin, H.,Chen, H.Z.,Cronan, J.E.,Bi, H.,Zhang, L.	Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis.	Nat Commun	2021	12	6932	6932	
7ETK	34796596	The complex structure of FtmOx1 bond with fumitremorgen B at 1.22 angstrom	2021-05-13	2021-12-01	Wu, L.,Wang, Z.,Cen, Y.,Wang, B.,Zhou, J.	Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7ETL	34796596	The crystal structure of FtmOx1-Y68F	2021-05-13	2021-12-01	Wu, L.,Wang, Z.,Cen, Y.,Wang, B.,Zhou, J.	Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7FH3	34818583	Crystal structure of the ATP sulfurylase domain of human PAPSS2	2021-07-29	2021-12-01	Zhang, P.,Zhang, L.,Hou, Z.,Lin, H.,Gao, H.,Zhang, L.	Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.	Biochem.Biophys.Res.Commun.	2022	586	1	7	
7FHA	34818583	Crystal structure of the ATP sulfurylase domain of human PAPSS2 in complex with APS	2021-07-29	2021-12-01	Zhang, P.,Zhang, L.,Hou, Z.,Lin, H.,Gao, H.,Zhang, L.	Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.	Biochem.Biophys.Res.Commun.	2022	586	1	7	
7VLM		crystal structure of anti-CRISPR protein AcrIIA18	2021-10-04	2021-12-01	Wang, X.,Li, X.,Ma, Y.,He, J.,Liu, X.,Yu, G.,Yin, H.,Zhang, H.	Inhibition mechanisms of CRISPR-Cas9 by AcrIIA17 and AcrIIA18	Nucleic Acids Res.	2022	50	512	521	
7CY2	34956144	The open conformation of MSMEG_1954 from Mycobacterium smegmatis	2020-09-03	2021-12-08	Zhang, Q.,Liu, X.,Liu, H.,Zhang, B.,Yang, H.,Mi, K.,Guddat, L.W.,Rao, Z.	Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding.	Front Microbiol	2021	12	780954	780954	
7DK2		Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab	2020-11-22	2021-12-08	Sun, Y.,Liu, F.J.,Guo, H.T.,Wang, J.,Wang, R.,Zhang, M.,Wang, M.,Chen, S.	Architectural versatility of spike neutralization by a SARS-CoV-2 antibody	To Be Published	0	0	0	0	
7DMC	36513142	Dipyridamole binds to the N-terminal domain of human Hsp90A	2020-12-03	2021-12-08	Gao, J.,Zhou, C.,Zhong, Y.,Shi, L.,Luo, X.,Su, H.,Li, M.,Xu, Y.,Zhang, N.,Zhou, H.	Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines.	Biochem Pharmacol	2022	207	115376	115376	
7DMF	35140398	A de novo protein that rigidly extends the structure of tVHS-like domain in tepsin with a new designed domain	2020-12-03	2021-12-08	Huang, B.,Xu, Y.,Hu, X.,Liu, Y.,Liao, S.,Zhang, J.,Huang, C.,Hong, J.,Chen, Q.,Liu, H.	A backbone-centred energy function of neural networks for protein design.	Nature	2022	602	523	528	
7EM9	34851145	Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I	2021-04-13	2021-12-08	Yue, C.,Xiang, W.,Huang, X.,Sun, Y.,Xiao, J.,Liu, K.,Sun, Z.,Qiao, P.,Li, H.,Gan, J.,Ba, L.,Chai, Y.,Qi, J.,Liu, P.,Qi, P.,Zhao, Y.,Li, Y.,Qiu, H.J.,Gao, G.F.,Gao, G.,Liu, W.J.	Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.	J.Virol.	2022	96	0	0	
7EMA	34851145	Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I	2021-04-13	2021-12-08	Yue, C.,Xiang, W.,Huang, X.,Sun, Y.,Xiao, J.,Liu, K.,Sun, Z.,Qiao, P.,Li, H.,Gan, J.,Ba, L.,Chai, Y.,Qi, J.,Liu, P.,Qi, P.,Zhao, Y.,Li, Y.,Qiu, H.J.,Gao, G.F.,Gao, G.,Liu, W.J.	Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.	J.Virol.	2022	96	0	0	
7EMB	34851145	Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I	2021-04-13	2021-12-08	Yue, C.,Xiang, W.,Huang, X.,Sun, Y.,Xiao, J.,Liu, K.,Sun, Z.,Qiao, P.,Li, H.,Gan, J.,Ba, L.,Chai, Y.,Qi, J.,Liu, P.,Qi, P.,Zhao, Y.,Li, Y.,Qiu, H.J.,Gao, G.F.,Gao, G.,Liu, W.J.	Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.	J.Virol.	2022	96	0	0	
7EMC	34851145	Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I	2021-04-13	2021-12-08	Yue, C.,Xiang, W.,Huang, X.,Sun, Y.,Xiao, J.,Liu, K.,Sun, Z.,Qiao, P.,Li, H.,Gan, J.,Ba, L.,Chai, Y.,Qi, J.,Liu, P.,Qi, P.,Zhao, Y.,Li, Y.,Qiu, H.J.,Gao, G.F.,Gao, G.,Liu, W.J.	Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.	J.Virol.	2022	96	0	0	
7EMD	34851145	Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I	2021-04-13	2021-12-08	Yue, C.,Xiang, W.,Huang, X.,Sun, Y.,Xiao, J.,Liu, K.,Sun, Z.,Qiao, P.,Li, H.,Gan, J.,Ba, L.,Chai, Y.,Qi, J.,Liu, P.,Qi, P.,Zhao, Y.,Li, Y.,Qiu, H.J.,Gao, G.F.,Gao, G.,Liu, W.J.	Mooring Stone-Like Arg 114 Pulls Diverse Bulged Peptides: First Insight into African Swine Fever Virus-Derived T Cell Epitopes Presented by Swine Major Histocompatibility Complex Class I.	J.Virol.	2022	96	0	0	
7DGY	35140398	De novo designed protein H4C2R	2020-11-12	2021-12-15	Huang, B.,Xu, Y.,Hu, X.,Liu, Y.,Liao, S.,Zhang, J.,Huang, C.,Hong, J.,Chen, Q.,Liu, H.	A backbone-centred energy function of neural networks for protein design.	Nature	2022	602	523	528	
7DML		OXA-48 carbapenemase in complex with (R)-2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acrylic acid	2020-12-04	2021-12-15	Xiao, Y.C.,Chen, X.P.,Deng, J.,Yan, Y.H.,Zhu, K.R.,Li, G.,Yu, J.L.,Brem, J.,Chen, F.,Schofield, C.J.,Li, G.B.	Design and enantioselective synthesis of 3-(alpha-acrylic acid) benzoxaboroles to combat carbapenemase resistance	Chem.Commun.(Camb.)	2021	57	7709	7712	
7DN8	35046574	Crystal structure of Salmonella effector SopF in complex with ARF1	2020-12-09	2021-12-15	Xu, Y.,Cheng, S.,Zeng, H.,Zhou, P.,Ma, Y.,Li, L.,Liu, X.,Shao, F.,Ding, J.	ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy.	Nat.Struct.Mol.Biol.	2022	29	67	77	
7DNU	35481780	mRNA-decapping enzyme g5Rp with inhibitor insp6 complex	2020-12-10	2021-12-15	Yang, Y.,Zhang, C.,Li, X.,Li, L.,Chen, Y.,Yang, X.,Zhao, Y.,Chen, C.,Wang, W.,Zhong, Z.,Yang, C.,Huang, Z.,Su, D.	Structural Insight into Molecular Inhibitory Mechanism of InsP 6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp.	J.Virol.	2022	96	0	0	
7V5H	34866598	VcOrn native structure with N terminal tag	2021-08-17	2021-12-15	Zhang, J.,Sun, L.,Zhang, Q.,Bartlam, M.	Crystal structure of oligoribonuclease from Vibrio cholerae O1 El Tor with bound peptide.	Acta Crystallogr.,Sect.F	2021	77	437	443	
7V5Z	34861238	Crystal structure of heterotetrameric complex of Sa2YoeB-Sa2YefM toxin-antitoxin from Staphylococcus aureus	2021-08-18	2021-12-15	Xue, L.,Khan, M.H.,Yue, J.,Zhu, Z.,Niu, L.	The two paralogous copies of the YoeB-YefM toxin-antitoxin module in Staphylococcus aureus differ in DNA binding and recognition patterns.	J.Biol.Chem.	2022	298	101457	101457	
7DOV		The crystal structure of zebrafish tumor necrosis factor alpha	2020-12-17	2021-12-22	Duan, Y.,Xia, C.	The structure of zebrafish tumour necrosis factor alpha at 2.6 angstrom resolution	To Be Published	0	0	0	0	
7DPE		RNA methyltransferase METTL4	2020-12-18	2021-12-22	Luo, Q.,Ma, J.B.	Structure of RNA m6A methyltransferase METTL4 in complex with DNA at 2.75 Angstroms resolutioon	To Be Published	0	0	0	0	
7DPN		Crystal structure of BRD2(BD1)with ligand ZB-BD-224 bound	2020-12-20	2021-12-22	Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zgou, B.	Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency	To Be Published	0	0	0	0	
7DPO		Crystal Structure of BRD2(BD2)with Ligand ZB-BD-224 bound	2020-12-21	2021-12-22	Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zgou, B.	Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency	To Be Published	0	0	0	0	
7EE3	35012347	Crystal structure of PltC	2021-03-17	2021-12-22	Liu, X.,Chen, Z.,Jiao, X.,Jiang, X.,Qiu, J.,You, F.,Long, H.,Cao, H.,Fowler, C.C.,Gao, X.	Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.	Mbio	2022	13	0	0	
7EE5	35012347	Crystal structure of Neu5Gc bound PltC	2021-03-17	2021-12-22	Liu, X.,Chen, Z.,Jiao, X.,Jiang, X.,Qiu, J.,You, F.,Long, H.,Cao, H.,Fowler, C.C.,Gao, X.	Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.	Mbio	2022	13	0	0	
7EE6	35012347	Crystal structure of PltC toxin	2021-03-17	2021-12-22	Liu, X.,Chen, Z.,Jiao, X.,Jiang, X.,Qiu, J.,You, F.,Long, H.,Cao, H.,Fowler, C.C.,Gao, X.	Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.	Mbio	2022	13	0	0	
7EPN	33992958	Ketosteroid Isomerase KSI native	2021-04-27	2021-12-22	Liang, Y.,Li, W.,Liang, H.,Lou, X.,Liu, R.,Zhang, Q.,Bartlam, M.	Structural characterization and Kemp eliminase activity of the Mycobacterium smegmatis Ketosteroid Isomerase.	Biochem.Biophys.Res.Commun.	2021	560	159	164	
7EK5	34360624	prawn ferritin to coordinate with heavy metal ions	2021-04-03	2021-12-29	Wang, Y.,Zang, J.,Wang, C.,Zhang, X.,Zhao, G.	Structural Insights for the Stronger Ability of Shrimp Ferritin to Coordinate with Heavy Metal Ions as Compared to Human H-Chain Ferritin.	Int J Mol Sci	2021	22	0	0	
7F2S		Crystal structure of anti S-gatifloxacin antibody Fab fragment apo form	2021-06-14	2021-12-29	Wang, L.T.,Xie, W.,Jiao, W.Y.,Zhang, C.,Li, X.,Xu, Z.,Huang, X.,Lei, H.T.,Shen, X.	Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin	Rsc Adv	2021	11	39534	39544	
7F35		Crystal structure of anti S-gatifloxacin antibody Fab fragment in complex with S-gatifloxacin	2021-06-15	2021-12-29	Wang, L.T.,Xie, W.,Jiao, W.Y.,Zhang, C.,Li, X.,Xu, Z.,Huang, X.,Lei, H.T.,Shen, X.	Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin	Rsc Adv	2021	11	39534	39544	
7FEF	34919920	Crystal structure of AtMBD6 with DNA	2021-07-19	2021-12-29	Wu, Z.,Chen, S.,Zhou, M.,Jia, L.,Li, Z.,Zhang, X.,Min, J.,Liu, K.	Family-wide Characterization of Methylated DNA Binding Ability of Arabidopsis MBDs.	J.Mol.Biol.	2022	434	167404	167404	
7V6J	34838855	LcCOMT in complex with SAM	2021-08-20	2021-12-29	Song, S.,Chen, A.,Zhu, J.,Yan, Z.,An, Q.,Zhou, J.,Liao, H.,Yu, Y.	Structure basis of the caffeic acid O-methyltransferase from Ligusiticum chuanxiong to understand its selective mechanism.	Int.J.Biol.Macromol.	2022	194	317	330	
7V6L	34838855	LcCOMT in complex with SAH	2021-08-20	2021-12-29	Song, S.,Chen, A.,Zhu, J.,Yan, Z.,An, Q.,Zhou, J.,Liao, H.,Yu, Y.	Structure basis of the caffeic acid O-methyltransferase from Ligusiticum chuanxiong to understand its selective mechanism.	Int.J.Biol.Macromol.	2022	194	317	330	
7DU4	33925254	The structure of the M.tb MazF-mt9 toxin in complex with a fragment of cognate antitoxin	2021-01-08	2022-01-12	Chen, R.,Zhou, J.,Xie, W.	Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins.	Toxins	2021	13	0	0	
7DU5	33925254	The structure of the M.tb MazF-mt1 toxin in complex with a fragment of cognate antitoxin	2021-01-08	2022-01-12	Chen, R.,Zhou, J.,Xie, W.	Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins.	Toxins	2021	13	0	0	
7EZG	34862464	The structure of the human METTL6 enzyme in complex with SAH	2021-06-01	2022-01-12	Chen, R.,Zhou, J.,Liu, L.,Mao, X.L.,Zhou, X.,Xie, W.	Crystal structure of human METTL6, the m 3 C methyltransferase.	Commun Biol	2021	4	1361	1361	
7DTR	35411005	Structure of an AcrIF protein	2021-01-06	2022-01-19	Yang, L.,Zhang, L.,Yin, P.,Ding, H.,Xiao, Y.,Zeng, J.,Wang, W.,Zhou, H.,Wang, Q.,Zhang, Y.,Chen, Z.,Yang, M.,Feng, Y.	Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24.	Nat Commun	2022	13	1931	1931	
7DUB	34763944	Crystal structure of VIM-2 MBL in complex with 1-isopropyl-1H-imidazole-2-carboxylic acid	2021-01-08	2022-01-19	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DUE	34763944	Crystal structure of VIM-2 MBL in complex with (R)-1-(sec-butyl)-1H-imidazole-2-carboxylic acid	2021-01-08	2022-01-19	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DUX	34763944	Crystal structure of VIM-2 MBL in complex with 1-(but-3-en-1-yl)-1H-imidazole-2-carboxylic acid	2021-01-12	2022-01-19	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DUY	34763944	Crystal structure of VIM-2 MBL in complex with 1-(2-(1H-1,2,3-triazol-1-yl)ethyl)-1H-imidazole-2-carboxylic acid	2021-01-12	2022-01-19	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DUZ	34763944	Crystal structure of VIM-2 MBL in complex with 1-cyclobutyl-1H-imidazole-2-carboxylic acid	2021-01-12	2022-01-19	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DV0	34763944	Crystal structure of VIM-2 MBL in complex with 1-(4-(trifluoromethyl)benzyl)-1H-imidazole-2-carboxylic acid	2021-01-12	2022-01-19	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DV1	34763944	Crystal structure of VIM-2 MBL in complex with 1-(4-hydroxybenzyl)-1H-imidazole-2-carboxylic acid	2021-01-12	2022-01-19	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DVG		Crystal structure of rice immune receptor RGA5-HMA5 mutant.	2021-01-13	2022-01-19	Zhang, X.,Liu, J.F.	Crystal structure of rice immune receptor RGA5-HMA5.	To Be Published	0	0	0	0	
7DVP	35380892	SARS-CoV-2 Mpro mutant (H41A) in complex with nsp4|5 peptidyl substrate	2021-01-14	2022-01-19	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7DVW	35380892	SARS-CoV-2 Mpro mutant (H41A) in complex with nsp5|6 peptidyl substrate	2021-01-15	2022-01-19	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7DVX	35380892	SARS-CoV-2 Mpro mutant (H41A) in complex with nsp6|7 peptidyl substrate	2021-01-15	2022-01-19	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7DVY	35380892	SARS-CoV-2 Mpro mutant (H41A) in complex with nsp9|10 peptidyl substrate	2021-01-15	2022-01-19	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7DW0	35380892	SARS-CoV-2 Mpro mutant (H41A) in complex with nsp14|15 peptidyl substrate	2021-01-15	2022-01-19	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7DW6	35380892	SARS-CoV-2 Mpro mutant (H41A) in complex with nsp15|16 peptidyl substrate	2021-01-15	2022-01-19	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7DWC	34074097	Bacteroides thetaiotaomicron VPI5482 BTAxe1	2021-01-17	2022-01-19	Wang, L.,Han, X.,Wang, Y.,Wei, X.,Liu, S.,Shao, S.,Yang, S.,Sun, L.,Xin, F.	Rational Design for Broadened Substrate Specificity and Enhanced Activity of a Novel Acetyl Xylan Esterase from Bacteroides thetaiotaomicron.	J.Agric.Food Chem.	2021	69	6665	6675	
7F5F	34975921	SARS-CoV-2 ORF8 S84	2021-06-22	2022-01-19	Chen, X.,Zhou, Z.,Huang, C.,Zhou, Z.,Kang, S.,Huang, Z.,Jiang, G.,Hong, Z.,Chen, Q.,Yang, M.,He, S.,Liu, S.,Chen, J.,Li, K.,Li, X.,Liao, J.,Chen, J.,Chen, S.	Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses.	Front Immunol	2021	12	807134	807134	
7F8L	34975921	Crystal structure of Bat coronavirus RaTG13 ORF8 accessory protein	2021-07-02	2022-01-19	Chen, X.,Zhou, Z.,Huang, C.,Zhou, Z.,Kang, S.,Huang, Z.,Jiang, G.,Hong, Z.,Chen, Q.,Yang, M.,He, S.,Liu, S.,Chen, J.,Li, K.,Li, X.,Liao, J.,Chen, J.,Chen, S.	Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses.	Front Immunol	2021	12	807134	807134	
7VO4		Pimaricin type I PKS thioesterase domain (apo Pim TE)	2021-10-12	2022-01-19	Zhou, Y.,Tao, W.,Qi, Z.,Wei, J.,Shi, T.,Kang, Q.,Zheng, J.,Zhao, Y.,Bai, L.	Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain	Acs Catalysis	2022	12	762	776	
7VO5		Pimaricin type I PKS thioesterase domain (holo Pim TE)	2021-10-12	2022-01-19	Zhou, Y.,Tao, W.,Qi, Z.,Wei, J.,Shi, T.,Kang, Q.,Zheng, J.,Zhao, Y.,Bai, L.	Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain	Acs Catalysis	2022	12	762	776	
7VPG	35096974	Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98	2021-10-17	2022-01-19	Li, T.,Wen, Y.,Guo, H.,Yang, T.,Yang, H.,Ji, X.	Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.	Front Mol Biosci	2021	8	813248	813248	
7DYY	34763944	Crystal structure of VIM-2 MBL in complex with 1-((2-aminobenzo[d]thiazol-6-yl)methyl)-1H-imidazole-2-carboxylic acid	2021-01-23	2022-01-26	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DYZ	34763944	Crystal structure of VIM-2 MBL in complex with 1-(but-3-en-1-yl)-4-methyl-1H-imidazole-2-carboxylic acid	2021-01-23	2022-01-26	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DZ0	34763944	Crystal structure of VIM-2 MBL in complex with 1-(but-3-en-1-yl)-5-methyl-1H-imidazole-2-carboxylic acid	2021-01-23	2022-01-26	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DZ1	34763944	Crystal structure of VIM-2 MBL in complex with 1-benzyl-5-methyl-1H-imidazole-2-carboxylic acid	2021-01-23	2022-01-26	Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B.	Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2022	228	113965	113965	
7DZM		Crystal Structure of the cross-restricted T18A TCR and HLAB8101 bound to HIV-1 Gag TL9 peptide	2021-01-25	2022-01-26	Liu, Y.,San, D.,Yin, L.	Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection	Biorxiv	2021	0	0	0	
7DZN		Crystal Structure of the cross-restricted T18A TCR and HLAB4201 bound to HIV-1 Gag TL9 peptide	2021-01-25	2022-01-26	Liu, Y.,San, D.,Yin, L.	Cross-reactive TCR with alloreactivity for immunodominant HIV-1 epitope Gag TL9 with enhanced control of viral infection	Biorxiv	2021	0	0	0	
7VW0	35066349	Structure of a dimeric periplasmic protein	2021-11-09	2022-01-26	Yang, J.,Gao, M.,Wang, J.,He, C.,Wang, X.,Liu, L.	Structural basis of copper binding by a dimeric periplasmic protein forming a six-helical bundle.	J.Inorg.Biochem.	2022	229	111728	111728	
7VW1	35066349	Structure of a dimeric periplasmic protein bound with cuprous ions	2021-11-09	2022-01-26	Yang, J.,Gao, M.,Wang, J.,He, C.,Wang, X.,Liu, L.	Structural basis of copper binding by a dimeric periplasmic protein forming a six-helical bundle.	J.Inorg.Biochem.	2022	229	111728	111728	
7VW2	35066349	Structure of a dimeric periplasmic protein bound with cupric ions	2021-11-09	2022-01-26	Yang, J.,Gao, M.,Wang, J.,He, C.,Wang, X.,Liu, L.	Structural basis of copper binding by a dimeric periplasmic protein forming a six-helical bundle.	J.Inorg.Biochem.	2022	229	111728	111728	
7DGC	36499303	The structure of the Arabidopsis thaliana guanosine deaminase in reaction with 2'-O-Methylguanosine	2020-11-11	2022-02-02	Jia, Q.,Zhang, J.,Zeng, H.,Tang, J.,Xiao, N.,Gao, S.,Li, H.,Xie, W.	Substrate Specificity of GSDA Revealed by Cocrystal Structures and Binding Studies.	Int J Mol Sci	2022	23	0	0	
7DH1	36499303	The structure of the Arabidopsis thaliana guanosine deaminase in reaction with N2-Methylguanosine	2020-11-12	2022-02-02	Jia, Q.,Zhang, J.,Zeng, H.,Tang, J.,Xiao, N.,Gao, S.,Li, H.,Xie, W.	Substrate Specificity of GSDA Revealed by Cocrystal Structures and Binding Studies.	Int J Mol Sci	2022	23	0	0	
7DOY		The structure of the Arabidopsis thaliana guanosine deaminase in complex with 6-O-methylguanosine	2020-12-17	2022-02-02	Xie, W.,Jia, Q.,Zeng, H.	Asymmetric Catalysis of Arabidopsis thaliana Guanosine Deaminase Revealed by Crystal Structures	To Be Published	0	0	0	0	
7DUU	34967442	Crystal structure of HLA molecule with an KIR receptor	2021-01-11	2022-02-02	Yang, Y.,Bai, H.,Wu, Y.,Chen, P.,Zhou, J.,Lei, J.,Ye, X.,Brown, A.J.,Zhou, X.,Shu, T.,Chen, Y.,Wei, P.,Yin, L.	Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor.	Immunology	2022	165	341	354	
7E2P		The Crystal Structure of Mycoplasma bovis enolase	2021-02-07	2022-02-02	Chen, R.,Zhao, L.,Gan, R.,Feng, Z.,Cui, C.,Xie, X.,Hao, F.,Zhang, Z.,Wang, L.,Ran, T.,Wang, W.,Zhang, S.,Li, Y.,Zhang, W.,Pang, M.,Xiong, Q.,Shao, G.	Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases.	Front Mol Biosci	2022	8	811106	811106	
7E2Q		Crystal structure of Mycoplasma pneumoniae Enolase	2021-02-07	2022-02-02	Chen, R.,Zhao, L.,Gan, R.,Feng, Z.,Cui, C.,Xie, X.,Hao, F.,Zhang, Z.,Wang, L.,Ran, T.,Wang, W.,Zhang, S.,Li, Y.,Zhang, W.,Pang, M.,Xiong, Q.,Shao, G.	Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases.	Front Mol Biosci	2022	8	811106	811106	
7E1D	36647726	Se-DBD	2021-02-01	2022-02-09	Hong, S.,Guo, J.,Zhang, X.,Zhou, X.,Zhang, P.,Yu, F.	Structural basis of phosphorylation-induced activation of the response regulator VbrR.	Acta Biochim.Biophys.Sin.	2023	0	0	0	
7E1F	36647726	Native-DBD	2021-02-01	2022-02-09	Hong, S.,Guo, J.,Zhang, X.,Zhou, X.,Zhang, P.,Yu, F.	Structural basis of phosphorylation-induced activation of the response regulator VbrR.	Acta Biochim.Biophys.Sin.	2023	0	0	0	
7E1H	36647726	crystal structure of RD-BEF	2021-02-01	2022-02-09	Hong, S.,Guo, J.,Zhang, X.,Zhou, X.,Zhang, P.,Yu, F.	Structural basis of phosphorylation-induced activation of the response regulator VbrR.	Acta Biochim.Biophys.Sin.	2023	0	0	0	
7E22		Crystal structure of two pericyclases catalyzing [4+2] cycloaddition	2021-02-04	2022-02-09	Chi, C.B.,Wang, Z.D.,Liu, T.,Zhang, Z.Y.,Ma, M.	Crystal structure of two pericyclases catalyzing [4+2] cycloaddition	To Be Published	0	0	0	0	
7E30	35966606	Crystal structure of a novel alpha/beta hydrolase in apo form in complex with citrate	2021-02-07	2022-02-09	Pfaff, L.,Gao, J.,Li, Z.,Jackering, A.,Weber, G.,Mican, J.,Chen, Y.,Dong, W.,Han, X.,Feiler, C.G.,Ao, Y.F.,Badenhorst, C.P.S.,Bednar, D.,Palm, G.J.,Lammers, M.,Damborsky, J.,Strodel, B.,Liu, W.,Bornscheuer, U.T.,Wei, R.	Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase.	Acs Catalysis	2022	12	9790	9800	
7E31	35966606	Crystal structure of a novel alpha/beta hydrolase mutant in apo form	2021-02-07	2022-02-09	Pfaff, L.,Gao, J.,Li, Z.,Jackering, A.,Weber, G.,Mican, J.,Chen, Y.,Dong, W.,Han, X.,Feiler, C.G.,Ao, Y.F.,Badenhorst, C.P.S.,Bednar, D.,Palm, G.J.,Lammers, M.,Damborsky, J.,Strodel, B.,Liu, W.,Bornscheuer, U.T.,Wei, R.	Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase.	Acs Catalysis	2022	12	9790	9800	
7E4P		Crystal structure of tubulin in complex with Ansamitocin P3	2021-02-14	2022-02-16	Wang, Y.,Li, W.	C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids	To Be Published	0	0	0	0	
7EAX	35417717	Crystal complex of p53-V272M and antimony ion	2021-03-08	2022-02-16	Tang, Y.,Song, H.,Wang, Z.,Xiao, S.,Xiang, X.,Zhan, H.,Wu, L.,Wu, J.,Xing, Y.,Tan, Y.,Liang, Y.,Yan, N.,Li, Y.,Li, J.,Wu, J.,Zheng, D.,Jia, Y.,Chen, Z.,Li, Y.,Zhang, Q.,Zhang, J.,Zeng, H.,Tao, W.,Liu, F.,Wu, Y.,Lu, M.	Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.	Cell Rep	2022	39	110622	110622	
7EFJ	35089030	Crystal Structure Analysis of human PIN1	2021-03-21	2022-02-16	Liu, L.,Zhu, R.,Li, J.,Pei, Y.,Wang, S.,Xu, P.,Wang, M.,Wen, Y.,Zhang, H.,Du, D.,Ding, H.,Jiang, H.,Chen, K.,Zhou, B.,Yu, L.,Luo, C.	Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).	J.Med.Chem.	2022	65	2174	2190	
7EFX	35089030	Crystal Structure of human PIN1 complexed with covalent inhibitor	2021-03-23	2022-02-16	Liu, L.,Zhu, R.,Li, J.,Pei, Y.,Wang, S.,Xu, P.,Wang, M.,Wen, Y.,Zhang, H.,Du, D.,Ding, H.,Jiang, H.,Chen, K.,Zhou, B.,Yu, L.,Luo, C.	Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).	J.Med.Chem.	2022	65	2174	2190	
7EKV	35089030	Crystal Structure of human Pin1 complexed with a covalent inhibitor	2021-04-06	2022-02-16	Liu, L.,Zhu, R.,Li, J.,Pei, Y.,Wang, S.,Xu, P.,Wang, M.,Wen, Y.,Zhang, H.,Du, D.,Ding, H.,Jiang, H.,Chen, K.,Zhou, B.,Yu, L.,Luo, C.	Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).	J.Med.Chem.	2022	65	2174	2190	
7EVJ	34962793	Crystal structure of CBP bromodomain liganded with 9c	2021-05-21	2022-02-16	Xiang, Q.,Wang, C.,Wu, T.,Zhang, C.,Hu, Q.,Luo, G.,Hu, J.,Zhuang, X.,Zou, L.,Shen, H.,Wu, X.,Zhang, Y.,Kong, X.,Liu, J.,Xu, Y.	Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.	J.Med.Chem.	2022	65	785	810	
7F0M	35089030	Crystal Structure of human Pin1 complexed with a potent covalent inhibitor	2021-06-05	2022-02-16	Liu, L.,Zhu, R.,Li, J.,Pei, Y.,Wang, S.,Xu, P.,Wang, M.,Wen, Y.,Zhang, H.,Du, D.,Ding, H.,Jiang, H.,Chen, K.,Zhou, B.,Yu, L.,Luo, C.	Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1).	J.Med.Chem.	2022	65	2174	2190	
7E4Y		Crystal structure of tubulin in complex with L-DM4-SMe	2021-02-16	2022-02-23	Wang, Y.,Li, W.	C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids	To Be Published	0	0	0	0	
7V6F		Structure of Candida albicans Fructose-1,6-bisphosphate aldolase complexed with G3P	2021-08-20	2022-02-23	Wen, W.,Cao, H.,Huang, Y.,Tu, J.,Wan, C.,Wan, J.,Han, X.,Chen, H.,Liu, J.,Rao, L.,Su, C.,Peng, C.,Sheng, C.,Ren, Y.	Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.	J.Med.Chem.	2022	65	2656	2674	
7V6G		Structure of Candida albicans Fructose-1,6-bisphosphate aldolase mutation C157S with CN39	2021-08-20	2022-02-23	Wen, W.,Cao, H.,Huang, Y.,Tu, J.,Wan, C.,Wan, J.,Han, X.,Chen, H.,Liu, J.,Rao, L.,Su, C.,Peng, C.,Sheng, C.,Ren, Y.	Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.	J.Med.Chem.	2022	65	2656	2674	
7W27	35144965	Crystal structure of BEND3-BEN4-DNA complex	2021-11-22	2022-02-23	Zheng, L.,Liu, J.,Niu, L.,Kamran, M.,Yang, A.W.H.,Jolma, A.,Dai, Q.,Hughes, T.R.,Patel, D.J.,Zhang, L.,Prasanth, S.G.,Yu, Y.,Ren, A.,Lai, E.C.	Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.	Genes Dev.	2022	36	225	240	
7WRP	34974304	Crystal Structure of pks13-ACP domain from Corynebacterium diphtheriae	2022-01-27	2022-02-23	Chen, R.,Yuan, J.,Shi, X.,Tang, W.,Liu, X.	Crystal structures of FadD32 and pks13-ACP domain from Corynebacterium diphtheriae.	Biochem.Biophys.Res.Commun.	2022	590	152	157	
7E5X	35380892	THE CRYSTAL STRUCTURE OF COVID-19 MAIN PROTEASE apo form at 2.2 angstrom	2021-02-21	2022-03-02	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7E85		SnoaL-like domain-containing protein	2021-03-01	2022-03-02	Zhuang, J.	SnoaL-like domain-containing protein	To Be Published	0	0	0	0	
7EPM	35646544	human LDHC complexed with NAD+ and ethylamino acetic acid	2021-04-27	2022-03-02	Tan, H.,Wang, H.,Ma, J.,Deng, H.,He, Q.,Chen, Q.,Zhang, Q.	Identification of human LDHC4 as a potential target for anticancer drug discovery.	Acta Pharm Sin B	2022	12	2348	2357	
7F6L	35290797	Crystal structure of human MUS81-EME2 complex	2021-06-25	2022-03-02	Hua, Z.,Fang, Q.,Zhang, D.,Luo, Z.,Yuan, C.,Lin, Z.	Crystal structure of the human MUS81-EME2 complex.	Structure	2022	30	743	0	
7VSP	35023269	Crystal strcuture of the tandem B-Box domains of COL2	2021-10-27	2022-03-02	Zeng, X.,Lv, X.,Liu, R.,He, H.,Liang, S.,Chen, L.,Zhang, F.,Chen, L.,He, Y.,Du, J.	Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation.	J Integr Plant Biol	2022	64	731	740	
7VSQ	35023269	Crystal strcuture of the tandem B-Box domains of CONSTANS	2021-10-27	2022-03-02	Zeng, X.,Lv, X.,Liu, R.,He, H.,Liang, S.,Chen, L.,Zhang, F.,Chen, L.,He, Y.,Du, J.	Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation.	J Integr Plant Biol	2022	64	731	740	
7W09		UGT74AN2, Plant Steroid Glycosyltransferase	2021-11-18	2022-03-02	Huang, W.,He, Y.,Jiang, R.,Deng, Z.,Long, F.	Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity	Acs Catalysis	2022	0	2927	2937	
7W0K		plant glycosyltransferase	2021-11-18	2022-03-02	Huang, W.,He, Y.,Jiang, R.,Deng, Z.,Long, F.	Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity	Acs Catalysis	2022	0	2927	2937	
7W0Z		Glycosyltranferase UGT74AN2	2021-11-18	2022-03-02	Huang, W.,He, Y.,Jiang, R.,Deng, Z.,Long, F.	Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity	Acs Catalysis	2022	0	2927	2937	
7W10		UGT74AN2	2021-11-18	2022-03-02	Huang, W.,He, Y.,Jiang, R.,Deng, Z.,Long, F.	Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity	Acs Catalysis	2022	0	2927	2937	
7W11		glycosyltransferase	2021-11-19	2022-03-02	Huang, W.,He, Y.,Jiang, R.,Deng, Z.,Long, F.	Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity	Acs Catalysis	2022	0	2927	2937	
7W1B		Glycosyltransferase	2021-11-19	2022-03-02	Huang, W.,He, Y.,Jiang, R.,Deng, Z.,Long, F.	Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity	Acs Catalysis	2022	0	2927	2937	
7W1H		glycosyltransferase	2021-11-19	2022-03-02	Huang, W.,He, Y.,Jiang, R.,Deng, Z.,Long, F.	Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity	Acs Catalysis	2022	0	2927	2937	
7WKJ	35186375	A COVID-19 T-cell response detection method based on a newly identified human CD8+ T cell epitope from SARS-CoV-2-Hubei Province, 2021.	2022-01-10	2022-03-02	Zhang, J.,Lu, D.,Li, M.,Liu, M.,Yao, S.,Zhan, J.,Liu, W.J.,Gao, G.F.	A COVID-19 T-Cell Response Detection Method Based on a Newly Identified Human CD8 + T Cell Epitope from SARS-CoV-2 - Hubei Province, China, 2021.	China CDC Wkly	2022	4	83	87	
7DNT	35481780	mRNA-decapping enzyme g5Rp	2020-12-10	2022-03-09	Yang, Y.,Zhang, C.,Li, X.,Li, L.,Chen, Y.,Yang, X.,Zhao, Y.,Chen, C.,Wang, W.,Zhong, Z.,Yang, C.,Huang, Z.,Su, D.	Structural Insight into Molecular Inhibitory Mechanism of InsP 6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp.	J.Virol.	2022	96	0	0	
7EAV		The X-ray crystallographic structure of glycogen debranching enzyme from Sulfolobus solfataricus STB09	2021-03-08	2022-03-09	Li, Z.F.,Ban, X.F.,Tian, Y.X.,Li, C.M.,Gu, Z.B.	The X-ray Crystallographic Structure of Debranching Enzyme from Sulfolobus solfataricus STB09	To Be Published	0	0	0	0	
7F45	35301482	Structure of an Anti-CRISPR protein	2021-06-17	2022-03-09	Xie, Y.,Zhang, L.,Gao, Z.,Yin, P.,Wang, H.,Li, H.,Chen, Z.,Zhang, Y.,Yang, M.,Feng, Y.	AcrIF5 specifically targets DNA-bound CRISPR-Cas surveillance complex for inhibition.	Nat.Chem.Biol.	2022	18	670	677	
7OAR	35736675	Crystal structure of helicase Pif1 from Thermus oshimai in complex with parallel G-quadruplex	2021-04-20	2022-03-09	Dai, Y.X.,Guo, H.L.,Liu, N.N.,Chen, W.F.,Ai, X.,Li, H.H.,Sun, B.,Hou, X.M.,Rety, S.,Xi, X.G.	Structural mechanism underpinning Thermus oshimai Pif1-mediated G-quadruplex unfolding.	Embo Rep.	2022	23	0	0	
7F3S	35296687	Crystal structure of Sth1 Bromodomain in complex with H3K14bz peptide	2021-06-17	2022-03-16	Wang, D.,Yan, F.,Wu, P.,Ge, K.,Li, M.,Li, T.,Gao, Y.,Peng, C.,Chen, Y.	Global profiling of regulatory elements in the histone benzoylation pathway.	Nat Commun	2022	13	1369	1369	
7F4E	35296687	Crystal structure of Hst2 in complex with H3K9bz peptide	2021-06-18	2022-03-16	Wang, D.,Yan, F.,Wu, P.,Ge, K.,Li, M.,Li, T.,Gao, Y.,Peng, C.,Chen, Y.	Global profiling of regulatory elements in the histone benzoylation pathway.	Nat Commun	2022	13	1369	1369	
7F51	35296687	Crystal structure of Hst2 in complex with 2'-O-Benzoyl ADP Ribose	2021-06-21	2022-03-16	Wang, D.,Yan, F.,Wu, P.,Ge, K.,Li, M.,Li, T.,Gao, Y.,Peng, C.,Chen, Y.	Global profiling of regulatory elements in the histone benzoylation pathway.	Nat Commun	2022	13	1369	1369	
7W2B	35273182	The closed conformation of the sigma-1 receptor from Xenopus laevis	2021-11-23	2022-03-16	Meng, F.,Xiao, Y.,Ji, Y.,Sun, Z.,Zhou, X.	An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.	Nat Commun	2022	13	1267	1267	
7W2C	35273182	The closed conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084	2021-11-23	2022-03-16	Meng, F.,Xiao, Y.,Ji, Y.,Sun, Z.,Zhou, X.	An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.	Nat Commun	2022	13	1267	1267	
7W2G	35273182	An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by soaking	2021-11-23	2022-03-16	Meng, F.,Xiao, Y.,Ji, Y.,Sun, Z.,Zhou, X.	An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.	Nat Commun	2022	13	1267	1267	
7W2H	35273182	A double cysteine variant of the sigma-1 receptor from Xenopus laevis complexed with S1RA	2021-11-23	2022-03-16	Meng, F.,Xiao, Y.,Ji, Y.,Sun, Z.,Zhou, X.	An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.	Nat Commun	2022	13	1267	1267	
7EEY	34194665	The structure of the N-terminal doamin of the Schizosaccharomyces pombe Tad2 adenosine deaminase	2021-03-19	2022-03-23	Liu, X.,Zhou, J.,Ge, R.,Xie, W.	Functional and structural investigation of N-terminal domain of the SpTad2/3 heterodimeric tRNA deaminase.	Comput Struct Biotechnol J	2021	19	3384	3393	
7RW5	35293760	Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 1	2021-08-19	2022-03-23	Li, M.,Konteatis, Z.,Nagaraja, N.,Chen, Y.,Zhou, S.,Ma, G.,Gross, S.,Marjon, K.,Hyer, M.L.,Mandley, E.,Lein, M.,Padyana, A.K.,Jin, L.,Tong, S.,Peters, R.,Murtie, J.,Travins, J.,Medeiros, M.,Liu, P.,Frank, V.,Judd, E.T.,Biller, S.A.,Marks, K.M.,Sui, Z.,Reznik, S.K.	Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.	J.Med.Chem.	2022	65	4600	4615	
7F7W	35256594	JAK2-JH2	2021-06-30	2022-03-30	Hu, M.,Yang, T.,Yang, L.,Niu, L.,Zhu, J.,Zhao, A.,Shi, M.,Yuan, X.,Tang, M.,Yang, J.,Pei, H.,Yang, Z.,Chen, Q.,Ye, H.,Niu, T.,Chen, L.	Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms.	Blood Cancer J	2022	12	37	37	
7V8F	35294289	Crystal structure of UBE2L3 bound to HOIP RING1 domain.	2021-08-22	2022-03-30	Liu, J.,Wang, Y.,Wang, D.,Wang, Y.,Xu, X.,Zhang, Y.,Li, Y.,Zhang, M.,Gong, X.,Tang, Y.,Shen, L.,Li, M.,Pan, L.	Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7V8H	35294289	Crystal structure of LRR domain from Shigella flexneri IpaH1.4	2021-08-23	2022-03-30	Liu, J.,Wang, Y.,Wang, D.,Wang, Y.,Xu, X.,Zhang, Y.,Li, Y.,Zhang, M.,Gong, X.,Tang, Y.,Shen, L.,Li, M.,Pan, L.	Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7VFA	35324337	the complex of SARS-CoV2 3CL and NB1A2	2021-09-11	2022-03-30	Sun, Z.,Wang, L.,Li, X.,Fan, C.,Xu, J.,Shi, Z.,Qiao, H.,Lan, Z.,Zhang, X.,Li, L.,Zhou, X.,Geng, Y.	An extended conformation of SARS-CoV-2 main protease reveals allosteric targets.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7VFB	35324337	the complex of SARS-CoV2 3cl and NB2B4	2021-09-11	2022-03-30	Sun, Z.,Wang, L.,Li, X.,Fan, C.,Xu, J.,Shi, Z.,Qiao, H.,Lan, Z.,Zhang, X.,Li, L.,Zhou, X.,Geng, Y.	An extended conformation of SARS-CoV-2 main protease reveals allosteric targets.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7W26	35066379	monolignol ferulate transferase	2021-11-22	2022-03-30	Liu, X.,Dai, S.,Zhou, Y.,Liu, J.,Li, D.,Zhang, J.,Zhu, Y.,Zhao, Q.,Feng, Y.,Zhang, Y.	Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates.	Biochem.Biophys.Res.Commun.	2022	594	8	14	
7W5P	35654845	Crystal Structure of the dioxygenase CcTet from Coprinopsis cinereain bound to 12bp N6-methyldeoxyadenine (6mA) containing duplex DNA	2021-11-30	2022-03-30	Mu, Y.,Zhang, L.,Hu, J.,Zhou, J.,Lin, H.W.,He, C.,Chen, H.Z.,Zhang, L.	A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA.	Nat.Chem.Biol.	2022	18	733	741	
7E7C		Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27	2021-02-25	2022-04-06	Li, Y.,Li, H.	Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27	To Be Published	0	0	0	0	
7EGT	35355008	The crystal structure of the C-terminal domain of T. thermophilus UvrD complexed with the N-terminal domain of UvrB	2021-03-26	2022-04-06	Bharati, B.K.,Gowder, M.,Zheng, F.,Alzoubi, K.,Svetlov, V.,Kamarthapu, V.,Weaver, J.W.,Epshtein, V.,Vasilyev, N.,Shen, L.,Zhang, Y.,Nudler, E.	Crucial role and mechanism of transcription-coupled DNA repair in bacteria.	Nature	2022	604	152	159	
7EIO	35512546	Crystal Structure of Mei2 RRM3	2021-03-31	2022-04-06	Shen, S.,Jian, Y.,Cai, Z.,Li, F.,Lv, M.,Liu, Y.,Wu, J.,Fu, C.,Shi, Y.	Structural insights reveal the specific recognition of meiRNA by the Mei2 protein.	J Mol Cell Biol	2022	14	0	0	
7EIU	35512546	Crystal structure of Mei2 RRM3 in complex with 8mer meiRNA	2021-03-31	2022-04-06	Shen, S.,Jian, Y.,Cai, Z.,Li, F.,Lv, M.,Liu, Y.,Wu, J.,Fu, C.,Shi, Y.	Structural insights reveal the specific recognition of meiRNA by the Mei2 protein.	J Mol Cell Biol	2022	14	0	0	
7EJV	35614066	The co-crystal structure of DYRK2 with YK-2-69	2021-04-02	2022-04-06	Yuan, K.,Li, Z.,Kuang, W.,Wang, X.,Ji, M.,Chen, W.,Ding, J.,Li, J.,Min, W.,Sun, C.,Ye, X.,Lu, M.,Wang, L.,Ge, H.,Jiang, Y.,Hao, H.,Xiao, Y.,Yang, P.	Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.	Nat Commun	2022	13	2903	2903	
7F7I	34458841	Stapled Peptide Inhibitor in complex with PSD95 GK domain	2021-06-29	2022-04-06	Unarta, I.C.,Xu, J.,Shang, Y.,Cheung, C.H.P.,Zhu, R.,Chen, X.,Cao, S.,Cheung, P.P.,Bierer, D.,Zhang, M.,Huang, X.,Li, X.	Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.	Rsc Chem Biol	2021	2	1274	1284	
7VAH	35380892	The crystal structure of COVID-19 main protease in H41A mutation	2021-08-29	2022-04-06	Zhao, Y.,Zhu, Y.,Liu, X.,Jin, Z.,Duan, Y.,Zhang, Q.,Wu, C.,Feng, L.,Du, X.,Zhao, J.,Shao, M.,Zhang, B.,Yang, X.,Wu, L.,Ji, X.,Guddat, L.W.,Yang, K.,Rao, Z.,Yang, H.	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7WO1	35216507	Discovery of SARS-CoV-2 3CLpro peptidomimetic inhibitors through H41-specific protein-ligand interactions	2022-01-20	2022-04-13	Wang, Y.,Xu, B.,Ma, S.,Wang, H.,Shang, L.,Zhu, C.,Ye, S.	Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions.	Int J Mol Sci	2022	23	0	0	
7WO3	35216507	SARS-CoV-2 3CLpro	2022-01-20	2022-04-13	Wang, Y.,Xu, B.,Ma, S.,Wang, H.,Shang, L.,Zhu, C.,Ye, S.	Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions.	Int J Mol Sci	2022	23	0	0	
7WOF	35216507	SARS-CoV-2 3CLpro	2022-01-21	2022-04-13	Wang, Y.,Xu, B.,Ma, S.,Wang, H.,Shang, L.,Zhu, C.,Ye, S.	Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions.	Int J Mol Sci	2022	23	0	0	
7WOH	35216507	SARS-CoV-2 3CLpro	2022-01-21	2022-04-13	Wang, Y.,Xu, B.,Ma, S.,Wang, H.,Shang, L.,Zhu, C.,Ye, S.	Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions.	Int J Mol Sci	2022	23	0	0	
7EMJ		Crystal structure of T2R-TTL-Barbigerone complex	2021-04-14	2022-04-20	Yang, J.H.,Yan, W.	Crystal structure of T2R-TTL-barbigerone complex	To Be Published	0	0	0	0	
7EN5	35640608	The crystal structure of Escherichia coli MurR in complex with N-acetylglucosamine-6-phosphate	2021-04-16	2022-04-20	Zhang, Y.,Chen, W.,Wu, D.,Liu, Y.,Wu, Z.,Li, J.,Zhang, S.Y.,Ji, Q.	Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli.	Nucleic Acids Res.	2022	50	5948	5960	
7EN6	35640608	The crystal structure of Escherichia coli MurR in apo form	2021-04-16	2022-04-20	Zhang, Y.,Chen, W.,Wu, D.,Liu, Y.,Wu, Z.,Li, J.,Zhang, S.Y.,Ji, Q.	Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli.	Nucleic Acids Res.	2022	50	5948	5960	
7EN7	35640608	The crystal structure of Escherichia coli MurR in complex with N-acetylmuramic-acid-6-phosphate	2021-04-16	2022-04-20	Zhang, Y.,Chen, W.,Wu, D.,Liu, Y.,Wu, Z.,Li, J.,Zhang, S.Y.,Ji, Q.	Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli.	Nucleic Acids Res.	2022	50	5948	5960	
7ENH		Crystal structure of cas and anti-cas protein complex	2021-04-17	2022-04-20	Wang, Y.,Li, X.	Crystal structure of cas and anti-cas protein complex	To Be Published	0	0	0	0	
7ENR		Crystal structure of cas and anti-cas protein complex	2021-04-19	2022-04-20	Wang, Y.,Li, X.	Crystal structure of cas and anti-cas protein complex	To Be Published	0	0	0	0	
7V1K	35489058	Apo structure of sNASP core	2021-08-04	2022-04-20	Bao, H.,Carraro, M.,Flury, V.,Liu, Y.,Luo, M.,Chen, L.,Groth, A.,Huang, H.	NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes.	Nucleic Acids Res.	2022	50	5349	5368	
7V1L	35489058	Structure of sNASP core in complex with H3 alpha3 helix peptide	2021-08-04	2022-04-20	Bao, H.,Carraro, M.,Flury, V.,Liu, Y.,Luo, M.,Chen, L.,Groth, A.,Huang, H.	NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes.	Nucleic Acids Res.	2022	50	5349	5368	
7V1M	35489058	Structural basis for the co-chaperone relationship of sNASP and ASF1b	2021-08-04	2022-04-20	Bao, H.,Carraro, M.,Flury, V.,Liu, Y.,Luo, M.,Chen, L.,Groth, A.,Huang, H.	NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes.	Nucleic Acids Res.	2022	50	5349	5368	
7WVM	35309324	The complex structure of PD-1 and cemiplimab	2022-02-10	2022-04-20	Lu, D.,Xu, Z.,Zhang, D.,Jiang, M.,Liu, K.,He, J.,Ma, D.,Ma, X.,Tan, S.,Gao, G.F.,Chai, Y.	PD-1 N58-Glycosylation-Dependent Binding of Monoclonal Antibody Cemiplimab for Immune Checkpoint Therapy.	Front Immunol	2022	13	826045	826045	
7X4E	35420474	Structure of 10635-DndE	2022-03-02	2022-04-20	He, W.,Gao, H.,Wu, D.,Jiang, S.,Huang, W.,Chen, C.,Deng, Z.,Xiong, L.,Wu, G.,Wang, L.	Structural and Functional Analysis of DndE Involved in DNA Phosphorothioation in the Haloalkaliphilic Archaea Natronorubrum bangense JCM10635.	Mbio	2022	13	0	0	
7CTV		Crystal structure of Arabidopsis thaliana SOBIR1 kinase domain D489A mutant in complex with AMP-PNP and magnesium	2020-08-20	2022-04-27	Wei, X.,Wang, Y.L.,Gu, T.Y.,Xin, F.J.	Crystal structure of Arabidopsis thaliana SOBIR1 kinase domain D489A mutant in complex with AMP-PNP and magnesium	To Be Published	0	0	0	0	
7EOD	36588115	MITF HLHLZ Delta AKE	2021-04-22	2022-04-27	Liu, Z.,Chen, K.,Dai, J.,Xu, P.,Sun, W.,Liu, W.,Zhao, Z.,Bennett, S.P.,Li, P.,Ma, T.,Lin, Y.,Kawakami, A.,Yu, J.,Wang, F.,Wang, C.,Li, M.,Chase, P.,Hodder, P.,Spicer, T.P.,Scampavia, L.,Cao, C.,Pan, L.,Dong, J.,Chen, Y.,Yu, B.,Guo, M.,Fang, P.,Fisher, D.E.,Wang, J.	A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.	Cell Res.	2023	33	55	70	
7ETS		Crystal structure of crp protein from Gardnerella Vaginalis	2021-05-13	2022-04-27	Dong, H.J.,Wang, S.,Zhang, J.M.,Gu, L.	Crystal structure of crp protein from Gardnerella Vaginalis	To Be Published	0	0	0	0	
7F00	35414267	Crystal structure of SPD_0310	2021-06-03	2022-04-27	Cao, K.,Zhang, T.,Li, N.,Yang, X.Y.,Ding, J.,He, Q.Y.,Sun, X.	Identification and Tetramer Structure of Hemin-Binding Protein SPD_0310 Linked to Iron Homeostasis and Virulence of Streptococcus pneumoniae.	Msystems	2022	7	0	0	
7W7X	35438229	The crystal structure of human abl1 kinase domain in complex with ABL1-A11	2021-12-06	2022-04-27	Chen, P.,Sun, J.,Zhu, C.,Tang, G.,Wang, W.,Xu, M.,Xiang, M.,Zhang, C.J.,Zhang, Z.M.,Gao, L.,Yao, S.Q.	Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7WM7	35363470	Threonyl-tRNA synthetase from Salmonella enterica in complex with an inhibitor	2022-01-14	2022-04-27	Cai, Z.,Chen, B.,Yu, Y.,Guo, J.,Luo, Z.,Cheng, B.,Xu, J.,Gu, Q.,Zhou, H.	Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases.	J.Med.Chem.	2022	65	5800	5820	
7WMF	35363470	Threonyl-tRNA synthetase from Salmonella enterica in complex with an inhibitor	2022-01-14	2022-04-27	Cai, Z.,Chen, B.,Yu, Y.,Guo, J.,Luo, Z.,Cheng, B.,Xu, J.,Gu, Q.,Zhou, H.	Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases.	J.Med.Chem.	2022	65	5800	5820	
7WMI	35363470	Threonyl-tRNA synthetase from Salmonella enterica in complex with an inhibitor	2022-01-14	2022-04-27	Cai, Z.,Chen, B.,Yu, Y.,Guo, J.,Luo, Z.,Cheng, B.,Xu, J.,Gu, Q.,Zhou, H.	Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases.	J.Med.Chem.	2022	65	5800	5820	
7EJH		Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F and 2-hydroxyisoindoline-1,3-dione complex	2021-04-02	2022-05-11	Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H.	Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition	Nat Catal	2022	0	0	0	
7EJH		Crystal structure of KRED mutant-F147L/L153Q/Y190P/L199A/M205F/M206F and 2-hydroxyisoindoline-1,3-dione complex	2021-04-02	2022-05-11	Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H.	Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition	Nat Catal	2022	0	0	0	
7EJJ		Crystal structure of KRED F147L/L153Q/Y190P variant and methyl methacrylate complex	2021-04-02	2022-05-11	Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H.	Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition	Nat Catal	2022	0	0	0	
7EJJ		Crystal structure of KRED F147L/L153Q/Y190P variant and methyl methacrylate complex	2021-04-02	2022-05-11	Huang, X.,Feng, J.,Cui, J.,Jiang, G.,Harrison, W.,Zang, X.,Zhou, J.,Wang, B.,Zhao, H.	Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition	Nat Catal	2022	0	0	0	
7ES4		the crystral structure of DndH-C-domain	2021-05-08	2022-05-11	Wu, D.,Tang, Y.,Chen, S.,He, Y.,Chang, X.,Zheng, W.,Deng, Z.,Li, Z.,Wang, L.,Wu, G.,Chen, S.	The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex	Nat Catal	2022	0	0	0	
7V9O	35513512	Crystal structure of the lanthipeptide zinc-metallopeptidase EryP mutant E802R from saccharopolyspora erythraea	2021-08-26	2022-05-11	Zhao, C.,Sheng, W.,Wang, Y.,Zheng, J.,Xie, X.,Liang, Y.,Wei, W.,Bao, R.,Wang, H.	Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases.	Nat.Chem.Biol.	2022	18	724	732	
7ER3	34463093	Crystal structure of beta-lactoglobulin complexed with chloroquine	2021-05-05	2022-05-18	Yao, Q.,Xing, Y.,Ma, J.,Wang, C.,Zang, J.,Zhao, G.	Binding of Chloroquine to Whey Protein Relieves Its Cytotoxicity while Enhancing Its Uptake by Cells.	J.Agric.Food Chem.	2021	69	10669	10677	
7ERL		GH43 domain of bifunctional endoxylanase and arabinofuranosidase of Bi0569	2021-05-06	2022-05-18	Liu, D.,Wang, C.	Structure of bifunctional endoxylanase and arabinofuranosidaseat GH43 domain of Bi0569 protein	To Be Published	0	0	0	0	
7FAT		Structure Determination of the RBD-NB1A7	2021-07-07	2022-05-18	Shi, Z.,Li, X.,Wang, L.,Sun, Z.,Zhang, H.,Chen, X.,Cui, Q.,Qiao, H.,Lan, Z.,Zhang, X.,Li, X.,Li, L.,Xu, J.,Gong, R.,Fan, C.,Geng, Y.	Structural basis of nanobodies neutralizing SARS-CoV-2 variants	Structure	2022	30	707	0	
7V7L	35534502	Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex	2021-08-21	2022-05-18	Diao, X.,Ye, F.,Zhang, M.,Ren, X.,Tian, X.,Lu, J.,Sun, X.,Hou, Z.,Chen, X.,Li, F.,Zhuang, J.,Ding, H.,Peng, C.,Rastinejad, F.,Luo, C.,Wu, D.	Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.	Nat Commun	2022	13	2529	2529	
7V7W	35534502	Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA)	2021-08-21	2022-05-18	Diao, X.,Ye, F.,Zhang, M.,Ren, X.,Tian, X.,Lu, J.,Sun, X.,Hou, Z.,Chen, X.,Li, F.,Zhuang, J.,Ding, H.,Peng, C.,Rastinejad, F.,Luo, C.,Wu, D.	Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.	Nat Commun	2022	13	2529	2529	
7VVB	35522713	Crystal Structure of KRas4A(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1	2021-11-05	2022-05-18	Zheng, Y.,Ding, L.,Meng, X.,Potter, M.,Kearney, A.L.,Zhang, J.,Sun, J.,James, D.E.,Yang, G.,Zhou, C.	Structural insights into Ras regulation by SIN1.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7VVG	35522713	Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1	2021-11-06	2022-05-18	Zheng, Y.,Ding, L.,Meng, X.,Potter, M.,Kearney, A.L.,Zhang, J.,Sun, J.,James, D.E.,Yang, G.,Zhou, C.	Structural insights into Ras regulation by SIN1.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7W5M	35587028	Crystal structure of AtNASP in complex of H3 alpha3 helix peptide	2021-11-30	2022-05-18	Liu, Y.,Chen, L.,Wang, N.,Wu, B.,Bao, H.,Huang, H.	Structural basis for histone H3 recognition by NASP in Arabidopsis.	J Integr Plant Biol	2022	64	2309	2313	
7WLX	35507418	A novel chemical derivative(53) of THRB agonist	2022-01-14	2022-05-18	Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y.	Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.	J.Med.Chem.	2022	65	7193	7211	
7WMG	35507418	A novel chemical derivative(52) of THRB agonist	2022-01-14	2022-05-18	Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y.	Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.	J.Med.Chem.	2022	65	7193	7211	
7WMH	35507418	A novel chemical derivative(56) of THRB agonist	2022-01-14	2022-05-18	Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y.	Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.	J.Med.Chem.	2022	65	7193	7211	
7WML	35507418	A novel chemical derivative(85) of THRB agonist	2022-01-15	2022-05-18	Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y.	Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.	J.Med.Chem.	2022	65	7193	7211	
7WMN	35507418	A novel chemical derivative(89) of THRB agonist	2022-01-15	2022-05-18	Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y.	Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.	J.Med.Chem.	2022	65	7193	7211	
7WZS	35446120	Crystal structure of Chromobacterium violaceum effector CopC in complex with host calmodulin and caspase-7	2022-02-19	2022-05-18	Liu, Y.,Zeng, H.,Hou, Y.,Li, Z.,Li, L.,Song, X.,Ding, J.,Shao, F.,Xu, Y.	Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases.	Mbio	2022	13	0	0	
7X8J	35677252	Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (unliganded)	2022-03-13	2022-05-18	Zhang, C.,Zhao, S.,Li, Y.S.,He, C.,Wang, X.,Liu, L.	Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1.	Front Plant Sci	2022	13	899738	899738	
7X8K	35677252	Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (product-bound)	2022-03-13	2022-05-18	Zhang, C.,Zhao, S.,Li, Y.S.,He, C.,Wang, X.,Liu, L.	Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1.	Front Plant Sci	2022	13	899738	899738	
7VRB	35585082	Structure of the Human BRG1/SS18 complex	2021-10-22	2022-05-25	Cheng, Y.,Shen, Z.,Gao, Y.,Chen, F.,Xu, H.,Mo, Q.,Chu, X.,Peng, C.L.,McKenzie, T.T.,Palacios, B.E.,Hu, J.,Zhou, H.,Long, J.	Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.	Nat Commun	2022	13	2724	2724	
7VRC		Structure of the Yeast SNF11/SNF2 complex	2021-10-22	2022-05-25	Cheng, Y.,Chen, F.,Zhou, H.,Long, J.	Structure of the Yeast SNF11/SNF2 complex	To Be Published	0	0	0	0	
7WKU	35336895	Structure of PDCoV Mpro in complex with an inhibitor	2022-01-11	2022-05-25	Wang, F.,Chen, C.,Wang, Z.,Han, X.,Shi, P.,Zhou, K.,Liu, X.,Xiao, Y.,Cai, Y.,Huang, J.,Zhang, L.,Yang, H.	The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals.	Viruses	2022	14	0	0	
7EW8	36525490	Legionella pneumophila effector AnkD	2021-05-24	2022-06-01	Chen, T.T.,Lin, Y.,Zhang, S.,Liu, S.,Song, L.,Zhong, W.,Luo, Z.Q.,Han, A.	Atypical Legionella GTPase effector hijacks host vesicular transport factor p115 to regulate host lipid droplet.	Sci Adv	2022	8	0	0	
7EXC		Crystal structure of T2R-TTL-1129A2 complex	2021-05-26	2022-06-01	Li, Y.,Liu, Y.,Zhu, Z.,Yan, W.,Zhang, C.,Yang, Z.,Bai, P.,Tang, M.,Shi, M.,He, W.,Fu, S.,Liu, J.,Han, K.,Li, J.,Xie, L.,Ye, H.,Yang, J.,Chen, L.	Structure-Based Design and Synthesis of N-Substituted 3-Amino-beta-Carboline Derivatives as Potent alpha beta-Tubulin Degradation Agents	J.Med.Chem.	2022	65	2675	2693	
7EXX		The structure of DndG	2021-05-28	2022-06-01	Wu, D.,Tang, Y.,Chen, S.,He, Y.,Chang, X.,Zheng, W.,Deng, Z.,Li, Z.,Wang, L.,Wu, G.,Chen, S.	The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex	Nat Catal	2022	0	0	0	
7EZF	35059131	Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase	2021-06-01	2022-06-01	Wang, X.,Zhao, R.,Ji, W.,Zhou, J.,Liu, Q.,Zhao, L.,Shen, Z.,Liu, S.,Xu, B.	Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.	Acs Med.Chem.Lett.	2022	13	118	127	
7EZP	35059131	Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase	2021-06-01	2022-06-01	Wang, X.,Zhao, R.,Ji, W.,Zhou, J.,Liu, Q.,Zhao, L.,Shen, Z.,Liu, S.,Xu, B.	Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.	Acs Med.Chem.Lett.	2022	13	118	127	
7EZR	35059131	Indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase	2021-06-01	2022-06-01	Wang, X.,Zhao, R.,Ji, W.,Zhou, J.,Liu, Q.,Zhao, L.,Shen, Z.,Liu, S.,Xu, B.	Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.	Acs Med.Chem.Lett.	2022	13	118	127	
7FAU	35276082	Structure Determination of the NB1B11-RBD Complex	2021-07-07	2022-06-01	Shi, Z.,Li, X.,Wang, L.,Sun, Z.,Zhang, H.,Chen, X.,Cui, Q.,Qiao, H.,Lan, Z.,Zhang, X.,Li, X.,Li, L.,Xu, J.,Gong, R.,Fan, C.,Geng, Y.	Structural basis of nanobodies neutralizing SARS-CoV-2 variants.	Structure	2022	30	707	0	
7X5R		Crystal structure of AtHPPD-Lancotrione complex	2022-03-05	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X5S		Crystal structure of AtHPPD-Y14157 complex	2022-03-05	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X5U		Crystal structure of AtHPPD-diketonitrile complex	2022-03-05	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X5W		Crystal structure of AtHPPD-Y18022 complex	2022-03-05	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X5X		Crystal structure of AtHPPD-YH20533 complex	2022-03-05	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X5Y	36599124	Crystal structure of AtHPPD-Y14240 complex	2022-03-05	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7X5Z	36599124	Crystal structure of AtHPPD-Y13162 complex	2022-03-05	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7X62	36599124	Crystal structure of AtHPPD-Y191051 complex	2022-03-06	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7X64	36599124	Crystal structure of AtHPPD-Y18027 complex	2022-03-06	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7X67	36599124	Crystal structure of AtHPPD-Y18406 complex	2022-03-06	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7X69	36599124	Crystal structure of AtHPPD-Y191053 complex	2022-03-06	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7X6M		Crystal structure of AtHPPD-Y191058 complex	2022-03-07	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X6N		Crystal structure of AtHPPD-Y191710 complex	2022-03-07	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X7L		Crystal structure of ZmHPPD-Y13161 complex	2022-03-09	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X8D		Crystal structure of AtHPPD-phenylpyruvate complex	2022-03-12	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X8E		Crystal structure of PfHPPD-Y13287 complex	2022-03-12	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7X8H	36599124	Crystal structure of AtHPPD-(+)-Usnic acid complex	2022-03-13	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7X8I	36599124	Crystal structure of AtHPPD-Shikonin complex	2022-03-13	2022-06-01	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7XNG		Crystal structure of CBP bromodomain liganded with Y08092(31g)	2022-04-28	2022-06-01	Xiang, Q.,Zhang, Y.,Wang, C.,Song, M.,Xu, Y.	Crystal structure of CBP bromodomain liganded with Y08092(31g)	To Be Published	0	0	0	0	
7DJM	35798975	Structure of four truncated and mutated forms of quenching protein	2020-11-20	2022-06-08	Yu, G.,Hao, J.,Pan, X.,Shi, L.,Zhang, Y.,Wang, J.,Fan, H.,Xiao, Y.,Yang, F.,Lou, J.,Chang, W.,Malnoe, A.,Li, M.	Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH.	Nat.Plants	2022	8	840	855	
7VQL		de novo designed based on 1r26	2021-10-20	2022-06-08	Zhang, L.	Rotamer-free protein sequence design based on deep learning and self-consistency.	Nat Comput Sci	2023	0	0	0	
7VQV		de novo design based on 1r26	2021-10-20	2022-06-08	Zhang, L.	Rotamer-free protein sequence design based on deep learning and self-consistency.	Nat Comput Sci	2023	0	0	0	
7VQW		de novo designed protein based on 1r26	2021-10-20	2022-06-08	Zhang, L.	Rotamer-free protein sequence design based on deep learning and self-consistency.	Nat Comput Sci	2023	0	0	0	
7VRA	35446588	The crystal structure of EGFR T790M/C797S with the inhibitor HC5476	2021-10-22	2022-06-08	Chen, H.,Lai, M.,Zhang, T.,Chen, Y.,Tong, L.,Zhu, S.,Zhou, Y.,Ren, X.,Ding, J.,Xie, H.,Lu, X.,Ding, K.	Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.	J.Med.Chem.	2022	65	6840	6858	
7VRE	35446588	The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892	2021-10-22	2022-06-08	Chen, H.,Lai, M.,Zhang, T.,Chen, Y.,Tong, L.,Zhu, S.,Zhou, Y.,Ren, X.,Ding, J.,Xie, H.,Lu, X.,Ding, K.	Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.	J.Med.Chem.	2022	65	6840	6858	
7VRS	35647924	The complex of Acyltransferase and Acyl Carrier Protein Domains from module 9 of Salinomycin Polyketide Synthase	2021-10-24	2022-06-08	Feng, Y.,Zhang, F.,Huang, S.,Deng, Z.,Bai, L.,Zheng, J.	Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase.	Acta Crystallogr D Struct Biol	2022	78	779	791	
7VU4		de novo design based on 1r26	2021-11-01	2022-06-08	Zhang, L.	Rotamer-free protein sequence design based on deep learning and self-consistency.	Nat Comput Sci	2023	0	0	0	
7W6R		Structure of Bat coronavirus RaTG13 spike receptor-binding domain complexed with its receptor equine ACE2	2021-12-02	2022-06-08	Xu, Z.,Kang, X.,Han, P.,Du, P.,Li, L.,Zheng, A.,Deng, C.,Qi, J.,Zhao, X.,Wang, Q.,Liu, K.,Gao, G.F.	Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses	Nat Commun	2022	13	3547	0	
7W82	35188193	Crystal structure of maize RDR2	2021-12-07	2022-06-08	Du, X.,Yang, Z.,Ariza, A.J.F.,Wang, Q.,Xie, G.,Li, S.,Du, J.	Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production.	Plant Cell	2022	34	2140	2149	
7F4N		Crystal structure of SAH-bound MTA1-p1-p2 complex	2021-06-21	2022-06-15	Chen, J.,Hu, R.,Chen, Y.,Lin, X.,Xiang, W.,Chen, H.,Yao, C.,Liu, L.	Structural basis for MTA1c-mediated DNA N6-adenine methylation	Nat Commun	2022	13	3257	0	
7F4Q		Crystal structure of SAH-bound MTA1-p2 complex	2021-06-21	2022-06-15	Chen, J.,Hu, R.,Chen, Y.,Lin, X.,Xiang, W.,Chen, H.,Yao, C.,Liu, L.	Structural basis for MTA1c-mediated DNA N6-adenine methylation	Nat Commun	2022	13	3257	0	
7F4T		Crystal structure of SAM-bound TthMTA1-Ptep2 complex	2021-06-21	2022-06-15	Chen, J.,Hu, R.,Chen, Y.,Lin, X.,Xiang, W.,Chen, H.,Yao, C.,Liu, L.	Structural basis for MTA1c-mediated DNA N6-adenine methylation	Nat Commun	2022	13	3257	0	
7V1B	35758665	Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH)	2021-08-04	2022-06-15	Jia, H.,Zhong, Y.,Peng, C.,Gong, P.	Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct.	J.Virol.	2022	96	0	0	
7V1C	35758665	Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SIN)	2021-08-04	2022-06-15	Jia, H.,Zhong, Y.,Peng, C.,Gong, P.	Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct.	J.Virol.	2022	96	0	0	
7V1G	35758665	Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (with a GMP-Arg28 adduct and in complex with SAM)	2021-08-04	2022-06-15	Jia, H.,Zhong, Y.,Peng, C.,Gong, P.	Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct.	J.Virol.	2022	96	0	0	
7XKG	35711761	Crystal structure of an intramolecular mesacyl-CoA transferase from the 3-hydroxypropionic acid cycle of Roseiflexus castenholzii	2022-04-19	2022-06-15	Min, Z.,Zhang, X.,Wu, W.,Xin, Y.,Liu, M.,Wang, K.,Zhang, X.,He, Y.,Fan, C.,Wang, Z.,Xu, X.	Crystal Structure of an Intramolecular Mesaconyl-Coenzyme A Transferase From the 3-Hydroxypropionic Acid Cycle of Roseiflexus castenholzii .	Front Microbiol	2022	13	923367	923367	
7DRB	36131021	Crystal structure of plant receptor like protein RXEG1 with xyloglucanase XEG1	2020-12-27	2022-06-22	Sun, Y.,Wang, Y.,Zhang, X.,Chen, Z.,Xia, Y.,Wang, L.,Sun, Y.,Zhang, M.,Xiao, Y.,Han, Z.,Wang, Y.,Chai, J.	Plant receptor-like protein activation by a microbial glycoside hydrolase.	Nature	2022	610	335	342	
7WYM	35702321	Structure of the SARS-COV-2 main protease with 337 inhibitor	2022-02-16	2022-06-22	Qin, B.,Craven, G.B.,Hou, P.,Chesti, J.,Lu, X.,Child, E.S.,Morgan, R.M.L.,Niu, W.,Zhao, L.,Armstrong, A.,Mann, D.J.,Cui, S.	Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.	Acta Pharm Sin B	2022	12	3924	3933	
7WYO	35702321	Structure of the EV71 3Cpro with 338 inhibitor	2022-02-16	2022-06-22	Qin, B.,Craven, G.B.,Hou, P.,Chesti, J.,Lu, X.,Child, E.S.,Morgan, R.M.L.,Niu, W.,Zhao, L.,Armstrong, A.,Mann, D.J.,Cui, S.	Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.	Acta Pharm Sin B	2022	12	3924	3933	
7WYP	35702321	Structure of the SARS-COV-2 main protease with EN102 inhibitor	2022-02-16	2022-06-22	Qin, B.,Craven, G.B.,Hou, P.,Chesti, J.,Lu, X.,Child, E.S.,Morgan, R.M.L.,Niu, W.,Zhao, L.,Armstrong, A.,Mann, D.J.,Cui, S.	Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.	Acta Pharm Sin B	2022	12	3924	3933	
7X77	35862697	Ectodomain structure of per os infectivity factor 5	2022-03-09	2022-06-22	Li, Z.,Zhang, H.,Li, Z.,Fu, Y.,Wang, X.,Li, J.,Wang, K.,Wang, Z.,Zhang, T.,Wang, M.,Hu, Z.,Cao, S.	Structural Characterization of Per Os Infectivity Factor 5 (PIF5) Reveals the Essential Role of Intramolecular Interactions in Baculoviral Oral Infectivity.	J.Virol.	2022	96	0	0	
7XM7		Crystal Structure of the CBP in complex with the Y08188	2022-04-25	2022-06-22	Xiang, Q.,Zhang, Y.,Wang, C.,Song, M.,Xu, Y.	Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as potent and selective CBP bromodomain inhibitors	To Be Published	0	0	0	0	
7DRI	36351933	Structure of SspE_CTD_41658	2020-12-28	2022-06-29	Gao, H.,Gong, X.,Zhou, J.,Zhang, Y.,Duan, J.,Wei, Y.,Chen, L.,Deng, Z.,Wang, J.,Chen, S.,Wu, G.,Wang, L.	Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE.	Nat Commun	2022	13	6773	6773	
7DRR	36351933	Structure of SspE-R100A protein	2020-12-29	2022-06-29	Gao, H.,Gong, X.,Zhou, J.,Zhang, Y.,Duan, J.,Wei, Y.,Chen, L.,Deng, Z.,Wang, J.,Chen, S.,Wu, G.,Wang, L.	Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE.	Nat Commun	2022	13	6773	6773	
7DRS	36351933	Structure of SspE_40224	2020-12-29	2022-06-29	Gao, H.,Gong, X.,Zhou, J.,Zhang, Y.,Duan, J.,Wei, Y.,Chen, L.,Deng, Z.,Wang, J.,Chen, S.,Wu, G.,Wang, L.	Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE.	Nat Commun	2022	13	6773	6773	
7F5C		Crystal structure of BPTF-BRD with ligand DC-BPi-07 bound	2021-06-21	2022-06-29	Lu, T.,Lu, H.B.,Wang, J.,Han, J.,Xiao, S.,Jiang, H.,Chen, Y.,Yang, F.,Li, Q.,Jiang, H.L.,Chen, K.X.,Lu, W.C.,Lin, H.,Luo, C.	Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins	To Be Published	0	0	0	0	
7F5D		Crystal structure of BPTF-BRD with ligand DC-BPi-03 bound	2021-06-21	2022-06-29	Lu, T.,Lu, H.B.,Wang, J.,Han, J.,Xiao, S.,Jiang, H.,Chen, Y.,Yang, F.,Li, Q.,Jiang, H.L.,Chen, K.X.,Lu, W.C.,Lin, H.,Luo, C.	Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins	To Be Published	0	0	0	0	
7F5E		Crystal structure of BPTF-BRD with ligand DC-BPi-11 bound	2021-06-21	2022-06-29	Lu, T.,Lu, H.B.,Wang, J.,Han, J.,Xiao, S.,Jiang, H.,Chen, Y.,Yang, F.,Li, Q.,Jiang, H.L.,Chen, K.X.,Lu, W.C.,Lin, H.,Luo, C.	Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins	To Be Published	0	0	0	0	
7F5H	35722331	The crystal structure of RBD-Nanobody complex, DL28 (SC4)	2021-06-22	2022-06-29	Li, T.,Zhou, B.,Luo, Z.,Lai, Y.,Huang, S.,Zhou, Y.,Li, Y.,Gautam, A.,Bourgeau, S.,Wang, S.,Bao, J.,Tan, J.,Lavillette, D.,Li, D.	Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants.	Front Microbiol	2022	13	875840	875840	
7F6M		Crystal structure of APC complexed with a peptide inhibitor MAI-516	2021-06-25	2022-06-29	Jie, Z.,Zhang, J.	Discovery of Efficient Adenomatous Polyposis Coli - Rho Guanine Nucleotide Exchange Factor 4 Inhibitors by Employing High Binding Affinity Tracer	To Be Published	0	0	0	0	
7XW1		The crystal structure of AhpD from Pseudomonas aeruginosa	2022-05-25	2022-06-29	Xu, B.	The crystal structure of AhpD from Pseudomonas aeruginosa	To Be Published	0	0	0	0	
7XXK		Crystal structure of SARS-CoV-2 N-CTD in complex with GMP	2022-05-30	2022-06-29	Zhou, R.J.,Ni, X.C.,Lei, J.	Crystal structure of SARS-CoV-2 N-CTD in complex with GMP	To Be Published	0	0	0	0	
7F7O		APC-Asef FP assay tracer	2021-06-30	2022-07-06	Yang, X.,Zhang, J.	The tracer of FP assay for screening APC-Asef inhbitors	To Be Published	0	0	0	0	
7FH4	35764100	Chlorovirus PBCV-1 bi-functional dCMP/dCTP deaminase bi-DCD	2021-07-29	2022-07-06	Li, Y.H.,Hou, H.F.,Geng, Z.,Zhang, H.,She, Z.,Dong, Y.H.	Structural basis of a multi-functional deaminase in chlorovirus PBCV-1.	Arch.Biochem.Biophys.	2022	727	109339	109339	
7FH9	35764100	chlorovirus PBCV-1 bi-functional dCMP/dCTP deaminase bi-DCD with dTTP/dTMP bound	2021-07-29	2022-07-06	Li, Y.H.,Hou, H.F.,Geng, Z.,Zhang, H.,She, Z.,Dong, Y.H.	Structural basis of a multi-functional deaminase in chlorovirus PBCV-1.	Arch.Biochem.Biophys.	2022	727	109339	109339	
7FI4	35085557	Structure of AcrIF13	2021-07-30	2022-07-06	Wang, H.,Gao, T.,Zhou, Y.,Ren, J.,Guo, J.,Zeng, J.,Xiao, Y.,Zhang, Y.,Feng, Y.	Mechanistic insights into the inhibition of the CRISPR-Cas surveillance complex by anti-CRISPR protein AcrIF13.	J.Biol.Chem.	2022	298	101636	101636	
7VA8		Crystal structure of MiCGT	2021-08-27	2022-07-06	Wen, Z.,Zhang, Z.M.,Zhong, L.,Fan, J.,Li, M.,Ma, Y.,Zhou, Y.,Zhang, W.,Guo, B.,Chen, B.,Wang, J.B.	Directed Evolution of a Plant Glycosyltransferase for Chemo- and Regioselective Glycosylation of Pharmaceutically Significant Flavonoids	Acs Catalysis	2021	11	14781	14790	
7VBT	35584513	Crystal structure of RIOK2 in complex with CQ211	2021-09-01	2022-07-06	Ouyang, Y.,Si, H.,Zhu, C.,Zhong, L.,Ma, H.,Li, Z.,Xiong, H.,Liu, T.,Liu, Z.,Zhang, Z.,Zhang, Z.M.,Cai, Q.	Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- 4H -[1,2,3]triazolo[4,5- c ]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor.	J.Med.Chem.	2022	65	7833	7842	
7WSB	35911443	The ternary complex structure of FtmOx1 with a-ketoglutarate and 13-oxo-fumitremorgin B	2022-01-28	2022-07-06	Zhu, G.,Yan, W.,Wang, X.,Cheng, R.,Naowarojna, N.,Wang, K.,Wang, J.,Song, H.,Wang, Y.,Liu, H.,Xia, X.,Costello, C.E.,Liu, X.,Zhang, L.,Liu, P.	Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues.	Jacs Au	2022	2	1686	1698	
7XB1	35809570	Crystal structure of Omicron BA.3 RBD complexed with hACE2	2022-03-19	2022-07-06	Li, L.,Liao, H.,Meng, Y.,Li, W.,Han, P.,Liu, K.,Wang, Q.,Li, D.,Zhang, Y.,Wang, L.,Fan, Z.,Zhang, Y.,Wang, Q.,Zhao, X.,Sun, Y.,Huang, N.,Qi, J.,Gao, G.F.	Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1.	Cell	2022	185	2952	0	
7XM2		Crystal structure of Keap1 Kelch domain (residues 322-609) in complex with NXPZ-2	2022-04-24	2022-07-06	Liu, G.,Hou, R.,Xu, L.,Zhang, X.,Yan, J.,Xing, C.,Xu, K.,Zhuang, C.	Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides.	J.Med.Chem.	2022	65	8289	8302	
7WJV	35786925	Crystal structure of human liver FBPase complexed with an covalent inhibitor	2022-01-08	2022-07-13	Wen, W.,Cao, H.,Xu, Y.,Ren, Y.,Rao, L.,Shao, X.,Chen, H.,Wu, L.,Liu, J.,Su, C.,Peng, C.,Huang, Y.,Wan, J.	N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.	J.Med.Chem.	2022	65	9126	9143	
7FD6		Crystal structure of SmChiA in complex with 6a	2021-07-16	2022-07-20	Pengtao, Y.,Xi, J.	Discovery of Conformation Constrained Tetracyclic Compounds as potent Chitinase OfChi-h inhibitor with novel binding mode	To Be Published	0	0	0	0	
7FDN	35995835	Crystal structure of transcription factor WER in complex with EGL3	2021-07-17	2022-07-20	Wang, B.,Luo, Q.,Li, Y.,Du, K.,Wu, Z.,Li, T.,Shen, W.H.,Huang, C.H.,Gan, J.,Dong, A.	Structural insights into partner selection for MYB and bHLH transcription factor complexes.	Nat.Plants	2021	8	1108	1117	
7VKR	35776786	Crystal structure of D. melanogaster SAMTOR in complex with SAM	2021-09-30	2022-07-20	Tang, X.,Zhang, Y.,Wang, G.,Zhang, C.,Wang, F.,Shi, J.,Zhang, T.,Ding, J.	Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling.	Sci Adv	2022	8	0	0	
7Y6C	35861543	Crystal structure of the EscE/EsaG/EsaH complex	2022-06-18	2022-07-20	Zeng, Z.X.,Liu, L.Y.,Xiao, S.B.,Lu, J.F.,Liu, Y.L.,Li, J.,Zhou, Y.Z.,Liao, L.J.,Li, D.Y.,Zhou, Y.,Nie, P.,Xie, H.X.	Secreted in a Type III Secretion System-Dependent Manner, EsaH and EscE Are the Cochaperones of the T3SS Needle Protein EsaG of Edwardsiella piscicida.	Mbio	2022	13	0	0	
7FIA	35697070	Structure of AcrIF23	2021-07-30	2022-07-27	Ren, J.,Wang, H.,Yang, L.,Li, F.,Wu, Y.,Luo, Z.,Chen, Z.,Zhang, Y.,Feng, Y.	Structural and mechanistic insights into the inhibition of type I-F CRISPR-Cas system by anti-CRISPR protein AcrIF23.	J.Biol.Chem.	2022	298	102124	102124	
7XI0		Crystal structure of CBP bromodomain liganded with CCS150	2022-04-11	2022-07-27	Xu, H.,Luo, G.,Wu, T.,Hu, J.,Wang, C.,Wu, X.,Zhang, Y.,Xu, Y.,Xiang, Q.	Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain	Biochem.Biophys.Res.Commun.	2022	623	17	22	
7FH5		Structure of AdaV	2021-07-29	2022-08-03	Zhai, G.Q.,Gong, R.,Lin, Y.,Zhang, M.,Li, J.,Deng, Z.,Sun, J.,Chen, W.,Zhang, Z.G.	Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis	Acs Catalysis	2022	12	13910	13920	
7V1T		A dual Inhibitor Against Main Protease	2021-08-06	2022-08-10	Yu, W.Y.,Xiao, Y.B.,Zhao, Y.C.,Lai, M.D.	SARS-CoV-2 Mpro complex with inhibitor	To Be Published	0	0	0	0	
7V1U	35264812	Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12	2021-08-06	2022-08-10	Zhang, M.F.,Luo, X.Y.,Zhang, C.,Wang, C.,Wu, X.S.,Xiang, Q.P.,Xu, Y.,Zhang, Y.	Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.	Acta Pharmacol.Sin.	2022	43	2735	2748	
7WLN	35333526	Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13153	2022-01-13	2022-08-10	Li, J.,Zhang, C.,Xu, H.,Wang, C.,Dong, R.,Shen, H.,Zhuang, X.,Chen, X.,Li, Q.,Lu, J.,Zhang, M.,Wu, X.,Loomes, K.M.,Zhou, Y.,Zhang, Y.,Liu, J.,Xu, Y.	Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors.	J.Med.Chem.	2022	65	5760	5799	
7WNA	35333526	Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13120	2022-01-17	2022-08-10	Li, J.,Zhang, C.,Xu, H.,Wang, C.,Dong, R.,Shen, H.,Zhuang, X.,Chen, X.,Li, Q.,Lu, J.,Zhang, M.,Wu, X.,Loomes, K.M.,Zhou, Y.,Zhang, Y.,Liu, J.,Xu, Y.	Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors.	J.Med.Chem.	2022	65	5760	5799	
7WRG	35879313	Crystal structure of full-length kinesin-3 KLP-6	2022-01-26	2022-08-10	Wang, W.,Ren, J.,Song, W.,Zhang, Y.,Feng, W.	The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.	Nat Commun	2022	13	4281	4281	
7WUA		Crystal structures of FadD32 from Corynebacterium diphtheriae	2022-02-07	2022-08-10	Chen, R.,Yuan, J.,Shi, X.,Tang, W.	Crystal structures of FadD32 and pks13-ACP domain from Corynebacterium diphtheriae	Biochem Biophys Res Commun	2022	590	152	157	
7X6Y	35982226	TRIM7 in complex with C-terminal peptide of NSP5	2022-03-08	2022-08-10	Liang, X.,Xiao, J.,Li, X.,Liu, Y.,Lu, Y.,Wen, Y.,Li, Z.,Che, X.,Ma, Y.,Zhang, X.,Zhang, Y.,Jian, D.,Wang, P.,Xuan, C.,Yu, G.,Li, L.,Zhang, H.	A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.	Nat.Chem.Biol.	2022	18	1214	1223	
7X6Z	35982226	TRIM7 in complex with C-terminal peptide of NSP12	2022-03-08	2022-08-10	Liang, X.,Xiao, J.,Li, X.,Liu, Y.,Lu, Y.,Wen, Y.,Li, Z.,Che, X.,Ma, Y.,Zhang, X.,Zhang, Y.,Jian, D.,Wang, P.,Xuan, C.,Yu, G.,Li, L.,Zhang, H.	A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.	Nat.Chem.Biol.	2022	18	1214	1223	
7X70	35982226	TRIM7 in complex with C-terminal peptide of NSP8	2022-03-08	2022-08-10	Liang, X.,Xiao, J.,Li, X.,Liu, Y.,Lu, Y.,Wen, Y.,Li, Z.,Che, X.,Ma, Y.,Zhang, X.,Zhang, Y.,Jian, D.,Wang, P.,Xuan, C.,Yu, G.,Li, L.,Zhang, H.	A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures.	Nat.Chem.Biol.	2022	18	1214	1223	
7V2J	35264812	Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 33	2021-08-09	2022-08-17	Zhang, M.F.,Luo, X.Y.,Zhang, C.,Wang, C.,Wu, X.S.,Xiang, Q.P.,Xu, Y.,Zhang, Y.	Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.	Acta Pharmacol.Sin.	2022	43	2735	2748	
7V4R	37924898	The crystal structure of KFDV NS3H bound with Pi	2021-08-14	2022-08-17	Zhang, C.,Li, Y.,Samad, A.,He, H.,Ma, H.,Chen, Y.,Jin, T.	Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors.	Int.J.Biol.Macromol.	2023	0	127856	127856	
7V53	36216841	Crystal structure of full-length phospholipase D from Pseudomonas aeruginosa PAO1	2021-08-16	2022-08-17	Yang, X.,Li, Z.,Zhao, L.,She, Z.,Gao, Z.,Sui, S.F.,Dong, Y.,Li, Y.	Structural insights into PA3488-mediated inactivation of Pseudomonas aeruginosa PldA.	Nat Commun	2022	13	5979	5979	
7W18	35918517	Complex structure of alginate lyase PyAly with M5	2021-11-19	2022-08-17	Zhang, K.,Li, Z.,Zhu, Q.,Cao, H.,He, X.,Zhang, X.H.,Liu, W.,Lyu, Q.	Determination of oligosaccharide product distributions of PL7 alginate lyases by their structural elements.	Commun Biol	2022	5	782	782	
7Y9N	35757908	an engineered 5-helix bundle derived from SARS-CoV-2 S2 in complex with HR2P	2022-06-25	2022-08-17	Lin, X.,Guo, L.,Lin, S.,Chen, Z.,Yang, F.,Yang, J.,Wang, L.,Wen, A.,Duan, Y.,Zhang, X.,Dai, Y.,Yin, K.,Yuan, X.,Yu, C.,He, B.,Cao, Y.,Dong, H.,Li, J.,Zhao, Q.,Lu, G.	An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.	Emerg Microbes Infect	2022	11	1920	1935	
7V52		Structure of AdaV	2021-08-16	2022-08-24	Zhai, G.Q.,Gong, R.,Lin, Y.,Zhang, M.,Li, J.,Deng, Z.,Sun, J.,Chen, W.,Zhang, Z.G.	Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis	Acs Catalysis	2022	12	13910	13920	
7V54		Structure of AdaV	2021-08-16	2022-08-24	Zhai, G.Q.,Gong, R.,Lin, Y.,Zhang, M.,Li, J.,Deng, Z.,Sun, J.,Chen, W.,Zhang, Z.G.	Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis	Acs Catalysis	2022	12	13910	13920	
7V56		Structure of AdaV	2021-08-16	2022-08-24	Zhai, G.Q.,Gong, R.,Lin, Y.,Zhang, M.,Li, J.,Deng, Z.,Sun, J.,Chen, W.,Zhang, Z.G.	Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis	Acs Catalysis	2022	12	13910	13920	
7V57		Structure of AdaV	2021-08-16	2022-08-24	Zhai, G.Q.,Gong, R.,Lin, Y.,Zhang, M.,Li, J.,Deng, Z.,Sun, J.,Chen, W.,Zhang, Z.G.	Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis	Acs Catalysis	2022	12	13910	13920	
7V64		Crystal structure of Antibody 16A in complex with MUC1 Glycopeptide(GlycoT)	2021-08-19	2022-08-24	Han, Y.B.,Xu, L.	Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding	To Be Published	0	0	0	0	
7V6X	35618678	Crystal structure of HPPD complexed with Y18556	2021-08-20	2022-08-24	Yan, Y.C.,Wu, W.,Huang, G.Y.,Yang, W.C.,Chen, Q.,Qu, R.Y.,Lin, H.Y.,Yang, G.F.	Pharmacophore-Oriented Discovery of Novel 1,2,3-Benzotriazine-4-one Derivatives as Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.	J.Agric.Food Chem.	2022	70	6644	6657	
7VM8	35972963	Crystal structure of the MtDMI1 gating ring	2021-10-08	2022-08-24	Liu, H.,Lin, J.S.,Luo, Z.,Sun, J.,Huang, X.,Yang, Y.,Xu, J.,Wang, Y.F.,Zhang, P.,Oldroyd, G.E.D.,Xie, F.	Constitutive activation of a nuclear-localized calcium channel complex in Medicago truncatula.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7VP8		Crystal structure of ferritin from Ureaplasma urealyticum	2021-10-15	2022-08-24	Wang, W.,Liu, X.,Wang, Y.,Wang, Y.,Fu, D.,Xi, H.,Zhao, Y.,Wang, H.	Distinct structural characteristics define a new subfamily of Mycoplasma ferritin	Chin.Chem.Lett.	2022	33	4952	4955	
7VYU		Crystal structure of NatS	2021-11-15	2022-08-24	Yu, Y.,He, C.,Wu, L.,Zhang, Y.	Crystal structure of NatS	To Be Published	0	0	0	0	
7XPY	35947662	Crystal structure of USP7 in complex with its inhibitor	2022-05-06	2022-08-24	Zhang, X.W.,Feng, N.,Liu, Y.C.,Guo, Q.,Wang, J.K.,Bai, Y.Z.,Ye, X.M.,Yang, Z.,Yang, H.,Liu, Y.,Yang, M.M.,Wang, Y.H.,Shi, X.M.,Liu, D.,Tu, P.F.,Zeng, K.W.	Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy.	Sci Adv	2022	8	0	0	
7YJ5	35920566	Crystal structure of Stenoloma chusanum chalcone synthase 1 (ScCHS1)	2022-07-19	2022-08-24	Ni, R.,Niu, M.,Fu, J.,Tan, H.,Zhu, T.T.,Zhang, J.,Lou, H.X.,Zhang, P.,Li, J.X.,Cheng, A.X.	Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum.	J Integr Plant Biol	2022	64	1935	1951	
7YJ6	35920566	Crystal structure of Stenoloma chusanum chalcone synthase 1 (ScCHS1) complex with CoA	2022-07-19	2022-08-24	Ni, R.,Niu, M.,Fu, J.,Tan, H.,Zhu, T.T.,Zhang, J.,Lou, H.X.,Zhang, P.,Li, J.X.,Cheng, A.X.	Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum.	J Integr Plant Biol	2022	64	1935	1951	
7YJ7	35920566	Crystal structure of Stenoloma chusanum chalcone synthase 1 (ScCHS1) complex with Naringenin	2022-07-19	2022-08-24	Ni, R.,Niu, M.,Fu, J.,Tan, H.,Zhu, T.T.,Zhang, J.,Lou, H.X.,Zhang, P.,Li, J.X.,Cheng, A.X.	Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum.	J Integr Plant Biol	2022	64	1935	1951	
7YJ8	35920566	Crystal structure of Stenoloma chusanum chalcone synthase 1 (ScCHS1) complex with Pinocembrin	2022-07-19	2022-08-24	Ni, R.,Niu, M.,Fu, J.,Tan, H.,Zhu, T.T.,Zhang, J.,Lou, H.X.,Zhang, P.,Li, J.X.,Cheng, A.X.	Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum.	J Integr Plant Biol	2022	64	1935	1951	
7YJ9	35920566	Crystal structure of Stenoloma chusanum chalcone synthase 1 (ScCHS1) complex with CoA and Naringenin	2022-07-19	2022-08-24	Ni, R.,Niu, M.,Fu, J.,Tan, H.,Zhu, T.T.,Zhang, J.,Lou, H.X.,Zhang, P.,Li, J.X.,Cheng, A.X.	Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum.	J Integr Plant Biol	2022	64	1935	1951	
7YJA	35920566	Crystal structure of Stenoloma chusanum chalcone synthase 1 (ScCHS1) complex with CoA and Pinocembrin	2022-07-19	2022-08-24	Ni, R.,Niu, M.,Fu, J.,Tan, H.,Zhu, T.T.,Zhang, J.,Lou, H.X.,Zhang, P.,Li, J.X.,Cheng, A.X.	Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum.	J Integr Plant Biol	2022	64	1935	1951	
7YJB	35920566	Crystal structure of Stenoloma chusanum chalcone synthase 1 (ScCHS1) complex with CoA and Eriodictyol	2022-07-19	2022-08-24	Ni, R.,Niu, M.,Fu, J.,Tan, H.,Zhu, T.T.,Zhang, J.,Lou, H.X.,Zhang, P.,Li, J.X.,Cheng, A.X.	Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum.	J Integr Plant Biol	2022	64	1935	1951	
7FI5		Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D	2021-07-30	2022-08-31	Cai, W.,Peng, S.,Xu, T.,Tian, Y.,Li, Y.,Liu, J.	Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D	to be published	0	0	0	0	
7FI9		Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D	2021-07-30	2022-08-31	Cai, W.,Peng, S.,Xu, T.,Tian, Y.,Li, Y.,Liu, J.	Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D	to be published	0	0	0	0	
7V4Q	37924898	The crystal structure of the apo form of KFDV NS3H	2021-08-14	2022-08-31	Zhang, C.,Li, Y.,Samad, A.,He, H.,Ma, H.,Chen, Y.,Jin, T.	Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors.	Int.J.Biol.Macromol.	2023	0	127856	127856	
7V7X		Structure of H194A AdaV	2021-08-22	2022-08-31	Zhai, G.Q.,Gong, R.,Lin, Y.,Zhang, M.,Li, J.,Deng, Z.,Sun, J.,Chen, W.,Zhang, Z.G.	Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis	Acs Catalysis	2022	12	13910	13920	
7V8N		Crystal structure of the PWWP-ARID domain of ARID4A	2021-08-23	2022-08-31	Ren, D.,Wei, X.,Lin, L.,Liu, L.,Fan, Y.,Lu, Q.,He, G.	Crystal structure of the PWWP-ARID of  ARID4A	To Be Published	0	0	0	0	
7V8Q		Crystal structure of antibody 14A in complex with MUC1 Glycopeptide(GlycoT)	2021-08-23	2022-08-31	Han, Y.B.,Xu, L.	Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding	To Be Published	0	0	0	0	
7V97	37018419	Arsenic-bound p53 DNA-binding domain mutant V272M	2021-08-24	2022-08-31	Song, H.,Wu, J.,Tang, Y.,Dai, Y.,Xiang, X.,Li, Y.,Wu, L.,Wu, J.,Liang, Y.,Xing, Y.,Yan, N.,Li, Y.,Wang, Z.,Xiao, S.,Li, J.,Zheng, D.,Chen, X.,Fang, H.,Ye, C.,Ma, Y.,Wu, Y.,Wu, W.,Li, J.,Zhang, S.,Lu, M.	Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties.	Sci Transl Med	2023	15	0	0	
7VAC		Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoST)	2021-08-28	2022-08-31	Han, Y.B.,Xu, L.	Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding	To Be Published	0	0	0	0	
7VAZ		Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoS)	2021-08-30	2022-08-31	Han, Y.B.,Xu, L.	Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding	To Be Published	0	0	0	0	
7Y78	35945427	Crystal structure of Cry78Aa	2022-06-21	2022-08-31	Cao, B.,Nie, Y.,Guan, Z.,Chen, C.,Wang, N.,Wang, Z.,Shu, C.,Zhang, J.,Zhang, D.	The crystal structure of Cry78Aa from Bacillus thuringiensis provides insights into its insecticidal activity.	Commun Biol	2022	5	801	801	
7Y79	35945427	Crystal structure of Cry78Aa	2022-06-21	2022-08-31	Cao, B.,Nie, Y.,Guan, Z.,Chen, C.,Wang, N.,Wang, Z.,Shu, C.,Zhang, J.,Zhang, D.	The crystal structure of Cry78Aa from Bacillus thuringiensis provides insights into its insecticidal activity.	Commun Biol	2022	5	801	801	
7VB8	37308495	SbSOMT in complex with resveratrol and nicotinamide adenine dinucleotide(NAD+)	2021-08-30	2022-09-07	Lui, A.C.W.,Pow, K.C.,Lin, N.,Lam, L.P.Y.,Liu, G.,Godwin, I.D.,Fan, Z.,Khoo, C.J.,Tobimatsu, Y.,Wang, L.,Hao, Q.,Lo, C.	Regioselective stilbene O-methylations in Saccharinae grasses.	Nat Commun	2023	14	3462	3462	
7VBO	36592931	Alginate binding domain CBM	2021-09-01	2022-09-07	Ji, S.,Tian, X.,Li, X.,She, Q.	Identification and structural analysis of a carbohydrate-binding module specific to alginate, a representative of a new family, CBM96.	J.Biol.Chem.	2023	299	102854	102854	
7VC8		Complex structure of AtHPPD with inhibitor PYQ3	2021-09-01	2022-09-07	Zeng, X.,Huang, Y.,Dong, J.,Ma, X.,Nan, J.X.,Chen, W.,Lin, H.Y.,Yang, W.C.,Liu, X.,Yin, J.,Yang, G.F.	Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress	Adv Agrochem	2022	0	0	0	
7W67	36108631	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide	2021-12-01	2022-09-07	Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y.	Structural basis for product specificities of MLL family methyltransferases.	Mol.Cell	2022	82	3810	0	
7W6A	36108631	Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex	2021-12-01	2022-09-07	Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y.	Structural basis for product specificities of MLL family methyltransferases.	Mol.Cell	2022	82	3810	0	
7W6I	36108631	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me1 peptide	2021-12-01	2022-09-07	Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y.	Structural basis for product specificities of MLL family methyltransferases.	Mol.Cell	2022	82	3810	0	
7W6J	36108631	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide	2021-12-01	2022-09-07	Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y.	Structural basis for product specificities of MLL family methyltransferases.	Mol.Cell	2022	82	3810	0	
7W6L	36108631	The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide	2021-12-01	2022-09-07	Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y.	Structural basis for product specificities of MLL family methyltransferases.	Mol.Cell	2022	82	3810	0	
7WMD	35613468	PQQ-dependent alcohol dehydrogenase detoxifying DON	2022-01-14	2022-09-07	Yang, H.,Yan, R.,Li, Y.,Lu, Z.,Bie, X.,Zhao, H.,Lu, F.,Chen, M.	Structure-Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification.	J.Agric.Food Chem.	2022	70	6764	6774	
7WMK	35613468	PQQ-dependent alcohol dehydrogenase complexed with PQQ	2022-01-15	2022-09-07	Yang, H.,Yan, R.,Li, Y.,Lu, Z.,Bie, X.,Zhao, H.,Lu, F.,Chen, M.	Structure-Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification.	J.Agric.Food Chem.	2022	70	6764	6774	
7X7W		The X-ray Crystallographic Structure of D-Psicose 3-epimerase from Clostridia bacterium	2022-03-10	2022-09-07	Xie, X.,Tian, Y.,Ban, X.,Li, C.,Yang, H.,Li, Z.	Crystal structure of a novel homodimeric D-allulose 3-epimerase from a Clostridia bacterium	Acta Crystallogr.,Sect.D	2022	78	1180	1191	
7F90		Crystal structure of SARS auxiliary protein in complex with human nuclear protein	2021-07-03	2022-09-14	Gao, X.,Tian, H.,Zhu, K.,Li, Q.,Hao, W.,Wang, L.,Qin, B.,Deng, H.,Cui, S.	Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport	Nat Commun	2022	13	4782	0	
7VD4	35378372	Crystal structure of BPTF-BRD with ligand TP248 bound	2021-09-06	2022-09-14	Lu, H.,Lu, T.,Zu, S.,Duan, Z.,Guang, Y.,Li, Q.,Ma, J.,Chen, D.,Li, B.,Lu, W.,Jiang, H.,Luo, C.,Ye, D.,Chen, K.,Lin, H.	Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold.	Bioorg.Chem.	2022	123	105768	105768	
7VUN	36561991	Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction	2021-11-03	2022-09-14	Sun, C.,Cheng, Y.,Liu, X.,Wang, G.,Min, W.,Wang, X.,Yuan, K.,Hou, Y.,Li, J.,Zhang, H.,Dong, H.,Wang, L.,Lou, C.,Sun, Y.,Yu, X.,Deng, H.,Xiao, Y.,Yang, P.	Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.	Acta Pharm Sin B	2022	12	4446	4457	
7W69	35966606	Crystal structure of a PSH1 mutant in complex with EDO	2021-12-01	2022-09-14	Pfaff, L.,Gao, J.,Li, Z.,Jackering, A.,Weber, G.,Mican, J.,Chen, Y.,Dong, W.,Han, X.,Feiler, C.G.,Ao, Y.F.,Badenhorst, C.P.S.,Bednar, D.,Palm, G.J.,Lammers, M.,Damborsky, J.,Strodel, B.,Liu, W.,Bornscheuer, U.T.,Wei, R.	Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase.	Acs Catalysis	2022	12	9790	9800	
7W69	35966606	Crystal structure of a PSH1 mutant in complex with EDO	2021-12-01	2022-09-14	Pfaff, L.,Gao, J.,Li, Z.,Jackering, A.,Weber, G.,Mican, J.,Chen, Y.,Dong, W.,Han, X.,Feiler, C.G.,Ao, Y.F.,Badenhorst, C.P.S.,Bednar, D.,Palm, G.J.,Lammers, M.,Damborsky, J.,Strodel, B.,Liu, W.,Bornscheuer, U.T.,Wei, R.	Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase.	Acs Catalysis	2022	12	9790	9800	
7X0H	36069444	Crystal structure of sugar binding protein CbpA complexed wtih glucose from Clostridium thermocellum	2022-02-22	2022-09-14	Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y.	Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum.	Mbio	2022	13	0	0	
7X0J	36069444	Crystal structure of sugar binding protein CbpB complexed wtih cellobiose from Clostridium thermocellum	2022-02-22	2022-09-14	Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y.	Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum.	Mbio	2022	13	0	0	
7X0K	36069444	Crystal structure of sugar binding protein CbpB complexed wtih cellotriose from Clostridium thermocellum	2022-02-22	2022-09-14	Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y.	Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum.	Mbio	2022	13	0	0	
7X0L	36069444	Crystal structure of sugar binding protein CbpB complexed wtih cellotetraose from Clostridium thermocellum	2022-02-22	2022-09-14	Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y.	Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum.	Mbio	2022	13	0	0	
7X0M	36069444	Crystal structure of sugar binding protein CbpB complexed wtih cellopentaose from Clostridium thermocellum	2022-02-22	2022-09-14	Yan, F.,Dong, S.,Liu, Y.J.,Yao, X.,Chen, C.,Xiao, Y.,Bayer, E.A.,Shoham, Y.,You, C.,Cui, Q.,Feng, Y.	Deciphering Cellodextrin and Glucose Uptake in Clostridium thermocellum.	Mbio	2022	13	0	0	
8GQE	36065466	Crystal structure of the W285A mutant of UVR8 in complex with RUP2	2022-08-30	2022-09-14	Wang, L.,Wang, Y.,Chang, H.,Ren, H.,Wu, X.,Wen, J.,Guan, Z.,Ma, L.,Qiu, L.,Yan, J.,Zhang, D.,Huang, X.,Yin, P.	RUP2 facilitates UVR8 redimerization via two interfaces.	Plant Commun.	2023	4	100428	100428	
7VO8		Structure of AtHPPD complexed with LSY-1	2021-10-12	2022-09-21	Fu, Y.X.,Liu, S.Y.,Guo, W.Y.,Dong, J.,Nan, J.X.,Lin, H.Y.,Mei, L.C.,Yang, W.C.,Yang, G.F.	In vivo diagnostics of abiotic plant stress responses via in situ real-time fluorescence imaging	Plant Physiol.	2022	190	196	201	
7W80	36167425	Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan	2021-12-07	2022-09-21	Ren, X.,Diao, X.,Zhuang, J.,Wu, D.	Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan.	Mol.Pharmacol.	2022	0	0	0	
7WJ8		Complex structure of AtHPPD-PyQ1	2022-01-05	2022-09-21	Zeng, X.,Huang, Y.,Dong, J.,Ma, X.,Nan, J.X.,Chen, W.,Lin, H.Y.,Yang, W.C.,Liu, X.,Yin, J.,Yang, G.F.	Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress	Adv Agrochem	2022	0	0	0	
7WJJ		Complex structure of AtHPPD-PyQ2	2022-01-06	2022-09-21	Zeng, X.,Huang, Y.,Dong, J.,Ma, X.,Nan, J.X.,Chen, W.,Lin, H.Y.,Yang, W.C.,Liu, X.,Yin, J.,Yang, G.F.	Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress	Adv Agrochem	2022	0	0	0	
7XS4	36177876	Crystal structure of URT1 in complex with AAAU RNA	2022-05-12	2022-09-21	Hu, Q.,Yang, H.,Li, M.,Zhu, L.,Lv, M.,Li, F.,Zhang, Z.,Ren, G.,Gong, Q.	Molecular mechanism underlying the di-uridylation activity of Arabidopsis TUTase URT1.	Nucleic Acids Res.	2022	50	10614	10625	
7YCW	36504814	Crystal Form 1 of Truncated Antitoxin ParD (2-54,containg RHH domain) from Pseudoalteromonas rubra	2022-07-01	2022-09-21	Wang, C.,Niu, C.,Hidayatullah, K.M.,Xue, L.,Zhu, Z.,Niu, L.	Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra.	Front Microbiol	2022	13	1053255	1053255	
7X9Q	36069713	Crystal structure of human STING complexed with compound BSP16	2022-03-15	2022-09-28	Feng, X.,Pan, L.,Qian, Z.,Liu, D.,Guan, X.,Feng, L.,Song, B.,Xu, X.,Tan, N.,Ma, Y.,Li, Z.,Wang, Z.,Bian, J.	Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.	J.Med.Chem.	2022	65	15048	15065	
7XDS	36083908	Crystal structure of wheat stem rust effector AvrSr35	2022-03-28	2022-09-28	Zhao, Y.B.,Liu, M.X.,Chen, T.T.,Ma, X.,Li, Z.K.,Zheng, Z.,Zheng, S.R.,Chen, L.,Li, Y.Z.,Tang, L.R.,Chen, Q.,Wang, P.,Ouyang, S.	Pathogen effector AvrSr35 triggers Sr35 resistosome assembly via a direct recognition mechanism.	Sci Adv	2022	8	0	0	
7XZ7	36005536	Mutant (D137A) of the N-terminal domain of fucoidan lyase FdlA	2022-06-02	2022-09-28	Wang, J.,Liu, Z.,Pan, X.,Wang, N.,Li, L.,Du, Y.,Li, J.,Li, M.	Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082.	Mar Drugs	2022	20	0	0	
7XZB	36005536	Mutant (Y242A) of the N-terminal domain of fucoidan lyase FdlA	2022-06-02	2022-09-28	Wang, J.,Liu, Z.,Pan, X.,Wang, N.,Li, L.,Du, Y.,Li, J.,Li, M.	Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082.	Mar Drugs	2022	20	0	0	
7VKG	35409252	Crystal structure of AF9 YEATS domain in complex with Compound 10	2021-09-29	2022-10-05	Liu, Y.,Jin, R.,Lu, H.,Bian, K.,Wang, R.,Wang, L.,Gao, R.,Zhang, J.,Wu, J.,Yao, X.,Liu, X.,Liu, D.,Wang, X.,Zhang, Z.,Ruan, K.	Fragment-Based Discovery of AF9 YEATS Domain Inhibitors.	Int J Mol Sci	2022	23	0	0	
7VKI	38015468	ESRP1 qRRM2 in complex with 12mer-RNA	2021-09-30	2022-10-05	Liu, D.,Dredge, B.K.,Bert, A.G.,Pillman, K.A.,Toubia, J.,Guo, W.,Dyakov, B.J.A.,Migault, M.M.,Conn, V.M.,Conn, S.J.,Gregory, P.A.,Gingras, A.C.,Patel, D.,Wu, B.,Goodall, G.J.	ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.	Nucleic Acids Res.	2023	0	0	0	
7VLB		Crystal structure of UGT109A1 from Bacillus	2021-10-02	2022-10-05	Chen, L.Q.,Zhang, Y.	Crystal structure of UGT109A1 from Bacillus	To Be Published	0	0	0	0	
7W28	35481649	Crystal Structure of SETD3-SAH in complex with betaA-4PyrAla73 peptide	2021-11-22	2022-10-05	Hintzen, J.C.J.,Ma, H.,Deng, H.,Witecka, A.,Andersen, S.B.,Drozak, J.,Guo, H.,Qian, P.,Li, H.,Mecinovic, J.	Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.	Protein Sci.	2022	31	0	0	
7VMA		The X-ray crystallographic structure of amylo-alpha-1,6-glucosidase from Thermococcus gammatolerans STB12	2021-10-08	2022-10-12	Li, Z.F.,Ban, X.F.,Wang, Y.M.,Li, C.M.,Gu, Z.B.	The X-ray Crystallographic Structure of Amylo-alpha-1,6-glucosidase from Thermococcus gannatilerans STB12	To Be Published	0	0	0	0	
7VMB	37787765	Crystal structure of IQSEC1-IQ motif, Sec7PH tandem in complex with calmodulin	2021-10-08	2022-10-12	Bai, G.,Li, H.,Qin, P.,Guo, Y.,Yang, W.,Lian, Y.,Ye, F.,Chen, J.,Wu, M.,Huang, R.,Li, J.,Lu, Y.,Zhang, M.	Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions.	J.Cell Biol.	2023	222	0	0	
7VMX	36192483	The Crystal Structure of EF-Tu and EF-Ts complex from Mycobacterium tuberculosis	2021-10-09	2022-10-12	Zhan, B.,Gao, Y.,Gao, W.,Li, Y.,Li, Z.,Qi, Q.,Lan, X.,Shen, H.,Gan, J.,Zhao, G.,Li, J.	Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis.	Commun Biol	2022	5	1052	1052	
7VMZ	36333470	Crystal structure of a human Coronavirus 229E antibody C04 Fab	2021-10-10	2022-10-12	Xiang, J.,Su, J.,Lan, Q.,Zhao, W.,Zhou, Y.,Xu, Y.,Niu, J.,Xia, S.,Qi, Q.,Sidhu, S.,Lu, L.,Miersch, S.,Yang, B.	Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein.	Commun Biol	2022	5	1179	1179	
7YT9	36149781	crystal structure of AGD1-4 of Arabidopsis AGDP3	2022-08-13	2022-10-12	Zhou, X.,Wei, M.,Nie, W.,Xi, Y.,Peng, L.,Zheng, Q.,Tang, K.,Satheesh, V.,Wang, Y.,Luo, J.,Du, X.,Liu, R.,Yang, Z.,La, H.,Zhong, Y.,Yang, Y.,Zhu, J.K.,Du, J.,Lei, M.	The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis.	J Integr Plant Biol	2022	64	2385	2395	
7YTA	36149781	crystal structure of NtAGDP3 AGD1-2 in complex with an H3K9me2 peptide	2022-08-13	2022-10-12	Zhou, X.,Wei, M.,Nie, W.,Xi, Y.,Peng, L.,Zheng, Q.,Tang, K.,Satheesh, V.,Wang, Y.,Luo, J.,Du, X.,Liu, R.,Yang, Z.,La, H.,Zhong, Y.,Yang, Y.,Zhu, J.K.,Du, J.,Lei, M.	The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis.	J Integr Plant Biol	2022	64	2385	2395	
8GXJ	36200834	Pseudomonas aeruginosa N-acetyltransferase domain-containing protein PA3270	2022-09-20	2022-10-12	Song, Y.,Zhang, S.,Ye, Z.,Song, Y.,Chen, L.,Tong, A.,He, Y.,Bao, R.	The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur.	Nucleic Acids Res.	2022	50	10586	10600	
8GXK	36200834	Pseudomonas jinjuensis N-acetyltransferase	2022-09-20	2022-10-12	Song, Y.,Zhang, S.,Ye, Z.,Song, Y.,Chen, L.,Tong, A.,He, Y.,Bao, R.	The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur.	Nucleic Acids Res.	2022	50	10586	10600	
7VMK		Crystal structure of tubulin with 3	2021-10-08	2022-10-19	Jifa, Z.,Lun, T.	Crystal structure of tubulin with 3	To Be Published	0	0	0	0	
7VOK	36192483	The Crystal structure of EF-Tu and GDP from Mycobacterium tuberculosis	2021-10-14	2022-10-19	Zhan, B.,Gao, Y.,Gao, W.,Li, Y.,Li, Z.,Qi, Q.,Lan, X.,Shen, H.,Gan, J.,Zhao, G.,Li, J.	Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis.	Commun Biol	2022	5	1052	1052	
7VPB	35981419	Crystal structure of a novel hydrolase in apo form	2021-10-15	2022-10-19	Li, Z.,Zhao, Y.,Wu, P.,Wang, H.,Li, Q.,Gao, J.,Qin, H.M.,Wei, H.,Bornscheuer, U.T.,Han, X.,Wei, R.,Liu, W.	Structural insight and engineering of a plastic degrading hydrolase Ple629.	Biochem.Biophys.Res.Commun.	2022	626	100	106	
8GVB	36130828	The complex between public TCR TD08 and HLA-A24 bound to HIV-1 Nef138-8 peptide	2022-09-14	2022-10-19	Ma, K.,Chai, Y.,Guan, J.,Tan, S.,Qi, J.,Kawana-Tachikawa, A.,Dong, T.,Iwamoto, A.,Shi, Y.,Gao, G.F.	Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors.	J Immunol.	2022	209	1652	1661	
8GVG	36130828	The complex between public TCR TD08 and HLA-A24 bound to HIV-1 Nef138-8 (2F) peptide	2022-09-15	2022-10-19	Ma, K.,Chai, Y.,Guan, J.,Tan, S.,Qi, J.,Kawana-Tachikawa, A.,Dong, T.,Iwamoto, A.,Shi, Y.,Gao, G.F.	Molecular Basis for the Recognition of HIV Nef138-8 Epitope by a Pair of Human Public T Cell Receptors.	J Immunol.	2022	209	1652	1661	
8GXF	36200834	Pseudomonas flexibilis GCN5 family acetyltransferase	2022-09-20	2022-10-19	Song, Y.,Zhang, S.,Ye, Z.,Song, Y.,Chen, L.,Tong, A.,He, Y.,Bao, R.	The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur.	Nucleic Acids Res.	2022	50	10586	10600	
7VN9	36333470	Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with C04 Fab	2021-10-10	2022-10-26	Xiang, J.,Su, J.,Lan, Q.,Zhao, W.,Zhou, Y.,Xu, Y.,Niu, J.,Xia, S.,Qi, Q.,Sidhu, S.,Lu, L.,Miersch, S.,Yang, B.	Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein.	Commun Biol	2022	5	1179	1179	
7VNG	36333470	Crystal structure of human coronavirus 229E spike protein receptor-binding domain in complex with S11 Fab	2021-10-11	2022-10-26	Xiang, J.,Su, J.,Lan, Q.,Zhao, W.,Zhou, Y.,Xu, Y.,Niu, J.,Xia, S.,Qi, Q.,Sidhu, S.,Lu, L.,Miersch, S.,Yang, B.	Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein.	Commun Biol	2022	5	1179	1179	
7VR2		Crystal structure of (-)-pulegone reductase PR1292 from Nepeta tenuifolia	2021-10-21	2022-10-26	Lin, W.,Wang, W.W.	Crystal structure of (-)-pulegone reductase PR1292 from Nepeta tenuifolia	To Be Published	0	0	0	0	
7WF6	36103920	Crystal structure of SNX13 RGS domain	2021-12-26	2022-10-26	Zhang, Y.,Chen, R.,Dong, Y.,Zhu, J.,Su, K.,Liu, J.,Xu, J.	Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins.	J.Mol.Biol.	2022	434	167823	167823	
7WF8	36103920	Crystal structure of mouse SNX25 RGS domain in space group P212121	2021-12-26	2022-10-26	Zhang, Y.,Chen, R.,Dong, Y.,Zhu, J.,Su, K.,Liu, J.,Xu, J.	Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins.	J.Mol.Biol.	2022	434	167823	167823	
7Y47	36161753	Crystal structure of bifunctional miltiradiene synthase from selaginella moellendorffii that complexed with GGPP	2022-06-14	2022-10-26	Tong, Y.,Ma, X.,Hu, T.,Chen, K.,Cui, G.,Su, P.,Xu, H.,Gao, W.,Jiang, T.,Huang, L.	Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase.	Plant Biotechnol J	2023	21	165	175	
7VTO		The crystal structure of PAK1 with the inhibitor GW8510	2021-10-30	2022-11-02	Zhu, S.J.	The crystal structure of PAK1 with the inhibitor GW8510	To Be Published	0	0	0	0	
7XHV	36343253	Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA	2022-04-10	2022-11-02	Sun, X.,Jing, L.,Li, F.,Zhang, M.,Diao, X.,Zhuang, J.,Rastinejad, F.,Wu, D.	Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7XI4	36343253	Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA	2022-04-12	2022-11-02	Sun, X.,Jing, L.,Li, F.,Zhang, M.,Diao, X.,Zhuang, J.,Rastinejad, F.,Wu, D.	Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7YDF	36350636	Crystal structure of human SARS2 catalytic domain	2022-07-04	2022-11-02	Yu, T.,Zhang, Y.,Zheng, W.Q.,Wu, S.,Li, G.,Zhang, Y.,Li, N.,Yao, R.,Fang, P.,Wang, J.,Zhou, X.L.	Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease.	Nucleic Acids Res.	2022	50	11755	11774	
7YDG	36350636	Crystal structure of human SARS2 catalytic domain with a disease related mutation	2022-07-04	2022-11-02	Yu, T.,Zhang, Y.,Zheng, W.Q.,Wu, S.,Li, G.,Zhang, Y.,Li, N.,Yao, R.,Fang, P.,Wang, J.,Zhou, X.L.	Selective degradation of tRNASer(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease.	Nucleic Acids Res.	2022	50	11755	11774	
7YIC		Crystal structure of reductase LSADH	2022-07-15	2022-11-02	Tang, J.,Liuqing, C.	crystal structure of reductase LSADH	To Be Published	0	0	0	0	
8GPX	36199277	YFV_E_YD73Fab_postfusion	2022-08-27	2022-11-02	Li, Y.,Chen, Z.,Wu, L.,Dai, L.,Qi, J.,Chai, Y.,Li, S.,Wang, Q.,Tong, Z.,Ma, S.,Duan, X.,Ren, S.,Song, R.,Liang, M.,Liu, W.,Yan, J.,Gao, G.F.	A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus.	Innovation (N Y)	2022	3	100323	100323	
7W6V	36322668	Crystal structure of a dicobalt-substituted small laccase at 2.47 angstrom	2021-12-02	2022-11-09	Yang, X.,Wu, W.,Chen, X.,Wu, F.,Fan, S.,Yu, P.,Mao, L.	A versatile artificial metalloenzyme scaffold enabling direct bioelectrocatalysis in solution.	Sci Adv	2022	8	0	0	
7VT2	35364499	Azumapecten Farreri ferritin	2021-10-27	2022-11-16	Zhang, C.,Liu, Y.,Zhang, T.,Lv, C.,Zang, J.,Zhao, G.	Structural comparison between the DNA-protective ability of scallop and shrimp ferritin from iron-induced oxidative damage.	Food Chem	2022	386	132827	132827	
7VUL		Structure of Klebsiella Phage P560 depolymerase	2021-11-02	2022-11-16	Li, M.,Chen, R.,Zhang, S.,Zhang, W.	Structure of Klebsiella Phage P560 depolymerase	To Be Published	0	0	0	0	
7VYO	36329057	The structure of GdmN	2021-11-14	2022-11-16	Wei, J.,Zhang, X.,Zhou, Y.,Cheng, X.,Lin, Z.,Tang, M.,Zheng, J.,Wang, B.,Kang, Q.,Bai, L.	Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.	Nat Commun	2022	13	6617	6617	
7VZQ	36329057	The structure of GdmN V24Y/G157A/R158A/G188R mutant in complex with carbamoyl adenylate intermediate	2021-11-16	2022-11-16	Wei, J.,Zhang, X.,Zhou, Y.,Cheng, X.,Lin, Z.,Tang, M.,Zheng, J.,Wang, B.,Kang, Q.,Bai, L.	Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.	Nat Commun	2022	13	6617	6617	
7WEG	35695292	Complex structure of PDZD7 and FCHSD2	2021-12-23	2022-11-16	Wang, H.,Zhao, D.,Du, H.,Zhai, X.,Wu, S.,Lin, L.,Xu, Z.,Lu, Q.	Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2.	Biochem.J.	2022	479	1393	1405	
7WID	36376309	Crystal structure of Staphylococcus aureus ClpP in complex with ZG180	2022-01-03	2022-11-16	Wei, B.,Zhang, T.,Wang, P.,Pan, Y.,Li, J.,Chen, W.,Zhang, M.,Ji, Q.,Wu, W.,Lan, L.,Gan, J.,Yang, C.G.	Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.	Nat Commun	2022	13	6909	6909	
7XBZ	36376309	Crystal structure of Staphylococcus aureus ClpP in complex with R-ZG197	2022-03-22	2022-11-16	Wei, B.,Zhang, T.,Wang, P.,Pan, Y.,Li, J.,Chen, W.,Zhang, M.,Ji, Q.,Wu, W.,Lan, L.,Gan, J.,Yang, C.G.	Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.	Nat Commun	2022	13	6909	6909	
7FF1		Structure of C34E136G/N36	2021-07-22	2022-11-23	Yu, D.W.,Qin, B.	Structure of C34E136G/N36	To Be Published	0	0	0	0	
7W1I		Crystal structure of carboxylesterase mutant from Thermobifida fusca with C8X and C9C	2021-11-19	2022-11-23	Von Haugwitz, G.,Han, X.,Pfaff, L.,Li, Q.,Wei, H.,Gao, J.,Methling, K.,Ao, Y.,Brack, Y.,Mican, J.,Feiler, C.G.,Weiss, M.S.,Bednar, D.,Palm, G.J.,Lalk, M.,Lammers, M.,Damborsky, J.,Weber, G.,Liu, W.,Bornscheuer, U.T.,Wei, R.	Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization	Acs Catalysis	2022	12	15259	15270	
7WEJ	36351391	Crystal structure of the mouse Wdr47 NTD.	2021-12-23	2022-11-30	Ren, J.,Li, D.,Liu, J.,Liu, H.,Yan, X.,Zhu, X.,Feng, W.	Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation.	Cell Rep	2022	41	111589	111589	
7YOA	36472443	High-resolution crystal structure of the mouse alpha-defensin cryptdin 14	2022-08-01	2022-11-30	Wang, Q.,Yang, Y.,Luo, G.,Zhou, Y.,Tolbert, W.D.,Pazgier, M.,Liao, C.,Lu, W.	Mouse alpha-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt.	Infect.Immun.	2023	91	0	0	
7DF1	36424464	Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv	2020-11-06	2022-12-07	Tian, X.,Liu, X.,Ding, J.,Wang, F.,Wang, K.,Liu, J.,Wei, Z.,Hao, X.,Li, Y.,Wei, X.,Zhang, H.,Sui, J.	An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice.	Nat Biomed Eng	2022	0	0	0	
7W3P		Crystal structure of RORgamma in complex with natural inverse agonist	2021-11-25	2022-12-07	Tian, S.Y.,Li, Y.	Crystal structure of RORgamma in complex with natural inverse agonist	To Be Published	0	0	0	0	
7Y4I	36456586	Crystal structure of SPINDLY in complex with GDP	2022-06-14	2022-12-07	Zhu, L.,Wei, X.,Cong, J.,Zou, J.,Wan, L.,Xu, S.	Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.	Nat Commun	2022	13	7424	7424	
7Y55		Crystal structure of a glutathione S-transferase Tau1 from Pinus densata in complex with GSH	2022-06-16	2022-12-07	Qu, C.,Kao, H.N.,Xu, H.,Wang, B.S.,Yang, Z.L.,Yang, Q.,Liu, G.F.,Wang, X.R.,Liu, Y.J.,Zeng, Q.Y.	Functional significance of asymmetrical retention of parental alleles in a hybrid pine species complex	J Syst Evol	2023	0	0	0	
7XNT		Crystal structure of PfHPPD-Y13161 complex	2022-04-29	2022-12-14	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,He, B.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structural insights of 4-Hydrophenylpyruvate dioxygenase inhibition by structurally diverse small molecules	Adv Agrochem	2022	0	0	0	
7YSK		Crystal structure of D-Cysteine desulfhydrase from Pectobacterium atrosepticum	2022-08-12	2022-12-14	Xu, X.,Yang, L.,Zhang, X.,Xing, X.,Zhou, J.	Characterization and structural basis of D-cysteine desulfhydrase from Pectobacterium atrosepticum	Tetrahedron	2022	0	133174	0	
7YSL		Crystal structure of D-Cysteine desulfhydrase with a trapped PLP-pyruvate geminal diamine	2022-08-12	2022-12-14	Xu, X.,Yang, L.,Zhang, X.,Xing, X.,Zhou, J.	Characterization and structural basis of D-cysteine desulfhydrase from Pectobacterium atrosepticum	Tetrahedron	2022	0	133174	0	
8HGQ	36493556	The apo-flavodoxin dimer from Synechococcus elongatus PCC 7942	2022-11-15	2022-12-14	Liu, S.,Chen, Y.,Du, T.,Zhao, W.,Liu, X.,Zhang, H.,Yuan, Q.,Gao, L.,Dong, Y.,Gao, X.,Gong, Y.,Cao, P.	A dimer-monomer transition captured by the crystal structures of cyanobacterial apo flavodoxin.	Biochem.Biophys.Res.Commun.	2022	639	134	141	
7WAQ	37308495	SbSOMT in complex with resveratrol	2021-12-14	2022-12-21	Lui, A.C.W.,Pow, K.C.,Lin, N.,Lam, L.P.Y.,Liu, G.,Godwin, I.D.,Fan, Z.,Khoo, C.J.,Tobimatsu, Y.,Wang, L.,Hao, Q.,Lo, C.	Regioselective stilbene O-methylations in Saccharinae grasses.	Nat Commun	2023	14	3462	3462	
7WAR	37308495	SbSOMT in complex with pinostilbene and nicotinamide adenine dinucleotide(NAD+)	2021-12-14	2022-12-21	Lui, A.C.W.,Pow, K.C.,Lin, N.,Lam, L.P.Y.,Liu, G.,Godwin, I.D.,Fan, Z.,Khoo, C.J.,Tobimatsu, Y.,Wang, L.,Hao, Q.,Lo, C.	Regioselective stilbene O-methylations in Saccharinae grasses.	Nat Commun	2023	14	3462	3462	
7WAS	37308495	SbSOMT in complex with pterostilbene and nicotinamide adenine dinucleotide(NAD+)	2021-12-14	2022-12-21	Lui, A.C.W.,Pow, K.C.,Lin, N.,Lam, L.P.Y.,Liu, G.,Godwin, I.D.,Fan, Z.,Khoo, C.J.,Tobimatsu, Y.,Wang, L.,Hao, Q.,Lo, C.	Regioselective stilbene O-methylations in Saccharinae grasses.	Nat Commun	2023	14	3462	3462	
7WYG	35536725	Crystal structure of P450BSbeta-L78I/Q85H/G290I variant in complex with palmitic acid.	2022-02-16	2022-12-21	Zhang, K.,Yu, A.,Chu, X.,Li, F.,Liu, J.,Liu, L.,Bai, W.J.,He, C.,Wang, X.	Biocatalytic Enantioselective beta-Hydroxylation of Unactivated C-H Bonds in Aliphatic Carboxylic Acids.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7XD8	36577062	Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form)	2022-03-26	2022-12-21	Wu, J.,Wang, X.,Liu, Q.,Lu, G.,Gong, P.	Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
8GV5	36494358	Crystal structure of PN-SIA28 in complex with influenza hemagglutinin A/swine/Guangdong/104/2013 (H1N1)	2022-09-14	2022-12-21	Chen, Y.,Wang, F.,Yin, L.,Jiang, H.,Lu, X.,Bi, Y.,Zhang, W.,Shi, Y.,Burioni, R.,Tong, Z.,Song, H.,Qi, J.,Gao, G.F.	Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes.	Nat Commun	2022	13	7603	7603	
8HDA		Crystal structure of Ubl1 (residues 18-111) of SARS-CoV-2	2022-11-03	2022-12-21	Ni, X.C.,Lei, J.	Crystal structure of Ubl1 (residues 18-111) of SARS-CoV-2	To Be Published	0	0	0	0	
7WET	36732502	Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela	2021-12-24	2022-12-28	Xu, H.,Zhao, H.,Ding, C.,Jiang, D.,Zhao, Z.,Li, Y.,Ding, X.,Gao, J.,Zhou, H.,Luo, C.,Chen, G.,Zhang, A.,Xu, Y.,Zhang, H.	Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.	Signal Transduct Target Ther	2023	8	51	51	
7WEU	36732502	Crystal structure of Peroxiredoxin I in complex with compound 19-048	2021-12-24	2022-12-28	Xu, H.,Zhao, H.,Ding, C.,Jiang, D.,Zhao, Z.,Li, Y.,Ding, X.,Gao, J.,Zhou, H.,Luo, C.,Chen, G.,Zhang, A.,Xu, Y.,Zhang, H.	Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.	Signal Transduct Target Ther	2023	8	51	51	
7WO2	35216507	SARS-CoV-2 3CLPro Peptidomimetic Inhibitor TPM5	2022-01-20	2022-12-28	Wang, Y.,Xu, B.,Ma, S.,Wang, H.,Shang, L.,Zhu, C.,Ye, S.	Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions.	Int J Mol Sci	2022	23	0	0	
7WZX	35622017	The structure of a Twitch Radical SAM Dehydrogenase SpeY	2022-02-19	2022-12-28	Zhang, J.,Hou, X.,Chen, Z.,Ko, Y.,Ruszczycky, M.W.,Chen, Y.,Zhou, J.,Liu, H.W.	Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.	J.Am.Chem.Soc.	2022	144	9910	9919	
7X0B	35622017	The structure of a Twitch Radical SAM Dehydrogenase SpeY	2022-02-21	2022-12-28	Zhang, J.,Hou, X.,Chen, Z.,Ko, Y.,Ruszczycky, M.W.,Chen, Y.,Zhou, J.,Liu, H.W.	Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.	J.Am.Chem.Soc.	2022	144	9910	9919	
7XSI	35701881	SdnG, a Diels Alderase catalyzed the formation of norbornene skeleton in Sordarin biosynthetic pathway	2022-05-14	2022-12-28	Liu, S.H.,Sun, J.L.,Hu, Y.L.,Zhang, L.,Zhang, X.,Yan, Z.Y.,Guo, X.,Guo, Z.K.,Jiao, R.H.,Zhang, B.,Tan, R.X.,Ge, H.M.	Biosynthesis of Sordarin Revealing a Diels-Alderase for the Formation of the Norbornene Skeleton.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7WQM	36566714	Crystal structure of Aldo-keto reductase 1C3 complexed with compound 24	2022-01-25	2023-01-04	Liu, Y.,Chen, Y.,Jiang, J.,Chu, X.,Guo, Q.,Zhao, L.,Feng, F.,Liu, W.,Zhang, X.,He, S.,Yang, P.,Fang, P.,Sun, H.	Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.	Eur.J.Med.Chem.	2022	247	115013	115013	
7WRM		The malate-bound dimer of chemoreceptor MCP2201 ligand binding domain	2022-01-27	2023-01-04	Guo, L.,Li, D.F.,Liu, S.J.	The repellent response to malate mediated by chemoreceptor MCP2201 in Comamonas testosteroni CNB-1	to be published	0	0	0	0	
7WH9	35475366	holo structure of emodin 1-OH O-methyltransferase complex with emodin and S-Adenosyl-L-homocysteine	2021-12-30	2023-01-11	Xue, Y.,Liang, Y.,Zhang, W.,Geng, C.,Feng, D.,Huang, X.,Dong, S.,Zhang, Y.,Sun, J.,Qi, F.,Lu, X.	Characterization and Structural Analysis of Emodin- O -Methyltransferase from Aspergillus terreus.	J.Agric.Food Chem.	2022	70	5728	5737	
7WJG		Streptococcus mutans BusR transcriptional factor	2022-01-06	2023-01-11	Li, X.,Liu, N.	Structural study of transcriptional factor BusR	To Be Published	0	0	0	0	
7XNF	36493785	Structure of SARS-CoV-2 antibody P2C-1F11 with GX/P2V/2017 RBD	2022-04-28	2023-01-11	Jia, Y.,Niu, S.,Hu, Y.,Chai, Y.,Zheng, A.,Su, C.,Wu, L.,Han, P.,Han, P.,Lu, D.,Liu, Z.,Yan, X.,Tian, D.,Chen, Z.,Qi, J.,Tian, W.X.,Wang, Q.,Gao, G.F.	Cross-reaction of current available SARS-CoV-2 MAbs against the pangolin-origin coronavirus GX/P2V/2017.	Cell Rep	2022	41	111831	111831	
7XPJ	36580600	crystal structure of rice ASI1 BAH domain	2022-05-04	2023-01-11	Zhang, J.,Yuan, J.,Lin, J.,Chen, L.,You, L.Y.,Chen, S.,Peng, L.,Wang, C.H.,Du, J.,Duan, C.G.	Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
7XPK	36580600	crystal structure of rice ASI1 BAH domain in complex with a rice SUVH6 peptide	2022-05-04	2023-01-11	Zhang, J.,Yuan, J.,Lin, J.,Chen, L.,You, L.Y.,Chen, S.,Peng, L.,Wang, C.H.,Du, J.,Duan, C.G.	Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
7XSW	36493785	Structure of SARS-CoV-2 antibody S309 with GX/P2V/2017 RBD	2022-05-15	2023-01-11	Jia, Y.,Niu, S.,Hu, Y.,Chai, Y.,Zheng, A.,Su, C.,Wu, L.,Han, P.,Han, P.,Lu, D.,Liu, Z.,Yan, X.,Tian, D.,Chen, Z.,Qi, J.,Tian, W.X.,Wang, Q.,Gao, G.F.	Cross-reaction of current available SARS-CoV-2 MAbs against the pangolin-origin coronavirus GX/P2V/2017.	Cell Rep	2022	41	111831	111831	
8BDP		A GH20 family sulfoglycosidase Bt4394 in complex with NAG-thiazoline and sulfite	2022-10-19	2023-01-11	Zhang, Z.,Dong, M.,Zallot, R.,Blackburn, G.M.,Wang, N.,Wang, C.,Chen, L.,Baumann, P.,Wu, Z.,Wang, Z.,Fan, H.,Roth, C.,Jin, Y.,He, Y.	Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases	Acs Catalysis	2022	0	0	0	
7W5L	37679059	The crystal structure of the oxidized form of Gluconobacter oxydans WSH-004 SNDH	2021-11-30	2023-01-18	Li, D.,Deng, Z.,Hou, X.,Qin, Z.,Wang, X.,Yin, D.,Chen, Y.,Rao, Y.,Chen, J.,Zhou, J.	Structural Insight into the Catalytic Mechanisms of an L-Sorbosone Dehydrogenase.	Adv Sci	2023	10	0	0	
7WIA	36620887	The apo-form of THF-II C22G riboswitch	2022-01-03	2023-01-18	Xu, L.,Xiao, Y.,Zhang, J.,Fang, X.	Structural insights into translation regulation by the THF-II riboswitch.	Nucleic Acids Res.	2023	51	952	965	
7WIB	36620887	The THF-II riboswitch bound to THF	2022-01-03	2023-01-18	Xu, L.,Xiao, Y.,Zhang, J.,Fang, X.	Structural insights into translation regulation by the THF-II riboswitch.	Nucleic Acids Res.	2023	51	952	965	
7WIE	36620887	The THF-II riboswitch bound to 7DG	2022-01-03	2023-01-18	Xu, L.,Xiao, Y.,Zhang, J.,Fang, X.	Structural insights into translation regulation by the THF-II riboswitch.	Nucleic Acids Res.	2023	51	952	965	
7WIF	36620887	The THF-II riboswitch bound to H4B	2022-01-03	2023-01-18	Xu, L.,Xiao, Y.,Zhang, J.,Fang, X.	Structural insights into translation regulation by the THF-II riboswitch.	Nucleic Acids Res.	2023	51	952	965	
7WII	36620887	The THF-II riboswitch bound to NPR	2022-01-03	2023-01-18	Xu, L.,Xiao, Y.,Zhang, J.,Fang, X.	Structural insights into translation regulation by the THF-II riboswitch.	Nucleic Acids Res.	2023	51	952	965	
7WLF		Crystal structure of the HSA Fe complex	2022-01-13	2023-01-18	Bai, H.H.,Xie, L.L.,Wang, W.M.,Wang, H.F.	Crystal structure of the HSA Fe complex	To be published	0	0	0	0	
8GXB	36610789	Crystal structure of NAD+ -II riboswitch in complex with NAD+	2022-09-19	2023-01-18	Xu, X.,Egger, M.,Li, C.,Chen, H.,Micura, R.,Ren, A.	Structure-based investigations of the NAD+-II riboswitch.	Nucleic Acids Res.	2023	51	54	67	
8GXC	36610789	Crystal structure of NAD+ -II riboswitch in complex with NMN	2022-09-19	2023-01-18	Xu, X.,Egger, M.,Li, C.,Chen, H.,Micura, R.,Ren, A.	Structure-based investigations of the NAD+-II riboswitch.	Nucleic Acids Res.	2023	51	54	67	
8H7A	36537216	Crystal structure of the dimer form KAT6A WH domain with its bound double stranded DNA	2022-10-19	2023-01-18	Weber, L.M.,Jia, Y.,Stielow, B.,Gisselbrecht, S.S.,Cao, Y.,Ren, Y.,Rohner, I.,King, J.,Rothman, E.,Fischer, S.,Simon, C.,Forne, I.,Nist, A.,Stiewe, T.,Bulyk, M.L.,Wang, Z.,Liefke, R.	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	Nucleic Acids Res.	2023	51	574	594	
7FCT		Crystal structure of metallo-beta-lactamase MBLBt2	2021-07-15	2023-01-25	Zhao, F.,Peng, D.H.,Zou, T.T.	Crystal structure of metallo-beta-lactamase MBLBt2	To Be Published	0	0	0	0	
7WJK		Complex structure of AtHPPD-ZWJ	2022-01-06	2023-01-25	Yang, G.-F.,Lin, H.-Y.,Dong, J.	Complex structure of AtHPPD-PyQ1	To Be Published	0	0	0	0	
7WNH	36442107	Crystal structure of Nurr1 binding to NBRE	2022-01-18	2023-01-25	Zhao, M.,Wang, N.,Guo, Y.,Li, J.,Yin, Y.,Dong, Y.,Zhu, J.,Peng, C.,Xu, T.,Liu, J.	Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7WNU		Mycobacterium tuberculosis Rnase J complex with 7nt RNA	2022-01-19	2023-01-25	Li, J.,Hu, J.,Bao, L.,Zhan, B.	Structural ans functional study of RNase J from Mycobacterium tuberculosis	To Be Published	0	0	0	0	
7WNV	37871388	Crystal structure of mutant estrogen receptor alpha Y537S in complex with CO9	2022-01-19	2023-01-25	Bai, C.,Lv, Y.,Xiong, S.,Wu, S.,Qi, L.,Ren, S.,Zhu, M.,Dong, H.,Shen, H.,Li, Z.,Zhu, Y.,Ye, H.,Hao, H.,Xiao, Y.,Xiang, H.,Luo, G.	X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles.	Bioorg.Chem.	2023	141	106919	106919	
7WR0	36624349	P32 of caspase-4 C258A mutant	2022-01-26	2023-01-25	Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.	Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.	Nat.Struct.Mol.Biol.	2023	30	261	272	
7WR1	36624349	P32 of caspase-4 C258A mutant in complex with OspC3 C-terminal ankyrin-repeat domain	2022-01-26	2023-01-25	Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.	Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.	Nat.Struct.Mol.Biol.	2023	30	261	272	
7WR2	36624349	Cryatal structure of OspC3 C-terminal ankyrin-repeat domain	2022-01-26	2023-01-25	Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.	Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.	Nat.Struct.Mol.Biol.	2023	30	261	272	
7WR3	36624349	Crystal structure of MBP-fused OspC3 in complex with calmodulin	2022-01-26	2023-01-25	Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.	Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.	Nat.Struct.Mol.Biol.	2023	30	261	272	
7WR4	36624349	Crystal structure of OspC3-calmodulin-caspase-4 complex	2022-01-26	2023-01-25	Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.	Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.	Nat.Struct.Mol.Biol.	2023	30	261	272	
7WR5	36624349	Crystal structure of OspC3-calmodulin-caspase-4 complex binding with 2'-aF-NAD+	2022-01-26	2023-01-25	Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.	Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.	Nat.Struct.Mol.Biol.	2023	30	261	272	
7WR6	36624349	Crystal structure of ADP-riboxanated caspase-4 in complex with Af1521	2022-01-26	2023-01-25	Hou, Y.,Zeng, H.,Li, Z.,Feng, N.,Meng, F.,Xu, Y.,Li, L.,Shao, F.,Ding, J.	Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.	Nat.Struct.Mol.Biol.	2023	30	261	272	
7XVH	36599124	Crystal structure of AtHPPD-Y13287 complex	2022-05-23	2023-01-25	Dong, J.,Dong, J.,Yu, X.H.,Yan, Y.C.,Nan, J.X.,Ye, B.Q.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.	J.Agric.Food Chem.	2023	71	1170	1177	
7YNY	36477586	Crystal structure of baculovirus LEF-3 from Helicoverpa armigera nucleopolyhedrovirus	2022-08-01	2023-01-25	Yin, J.,Fu, Y.,Rao, G.,Li, Z.,Tian, K.,Chong, T.,Kuang, K.,Wang, M.,Hu, Z.,Cao, S.	Structural transitions during the cooperative assembly of baculovirus single-stranded DNA-binding protein on ssDNA.	Nucleic Acids Res.	2022	50	13100	13113	
8HAV	36635324	An auto-activation mechanism of plant non-specific phospholipase C	2022-10-26	2023-01-25	Fan, R.,Zhao, F.,Gong, Z.,Chen, Y.,Yang, B.,Zhou, C.,Zhang, J.,Du, Z.,Wang, X.,Yin, P.,Guo, L.,Liu, Z.	Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.	Nat Commun	2023	14	194	194	
8HAW	36635324	An auto-activation mechanism of plant non-specific phospholipase C	2022-10-26	2023-01-25	Fan, R.,Zhao, F.,Gong, Z.,Chen, Y.,Yang, B.,Zhou, C.,Zhang, J.,Du, Z.,Wang, X.,Yin, P.,Guo, L.,Liu, Z.	Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.	Nat Commun	2023	14	194	194	
7WRN		ESRP1 RNaseH-qRRM1 tandem domain	2022-01-27	2023-02-01	Wu, B.X.,Guo, W.T.,Patel, D.J.	ESRP1 RNaseH-qRRM1 tandem domain	To Be Published	0	0	0	0	
7WZO	36806252	Crystal structure of the SARS-CoV-2 nucleocapsid protein N-terminal domain in complex with Ubl1	2022-02-18	2023-02-01	Ni, X.,Han, Y.,Zhou, R.,Zhou, Y.,Lei, J.	Structural insights into ribonucleoprotein dissociation by nucleocapsid protein interacting with non-structural protein 3 in SARS-CoV-2.	Commun Biol	2023	6	193	193	
7YTE	36949194	crystal structure of human FcmR-D1 bound to IgM C4-domain	2022-08-14	2023-02-01	Li, Y.,Shen, H.,Zhang, R.,Ji, C.,Wang, Y.,Su, C.,Xiao, J.	Immunoglobulin M perception by Fc mu R.	Nature	2023	615	907	912	
8HIT	36511654	Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4	2022-11-21	2023-02-01	Guan, J.,Liu, H.,Chai, Y.,Yu, J.,Yao, J.,Wang, J.,Pan, Z.,Zhang, J.,Zhou, Y.,Liu, H.,Yao, S.,Qi, J.,Feng, H.,Gao, G.F.,Wang, Q.,Shi, Y.,Tan, S.	Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer.	Mabs	2023	15	2153409	2153409	
7WUD		An (R)-Selective Transaminase mutant	2022-02-08	2023-02-08	Li, F.L.,Yu, H.M.	an (R)-Selective Transaminase mutant	To Be Published	0	0	0	0	
7X7Z	36690833	The crystal structure of 2+2/4+2 cyclase PloI4	2022-03-10	2023-02-08	Wang, H.,Zou, Y.,Li, M.,Tang, Z.,Wang, J.,Tian, Z.,Strassner, N.,Yang, Q.,Zheng, Q.,Guo, Y.,Liu, W.,Pan, L.,Houk, K.N.	A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions.	Nat.Chem.	2023	15	177	184	
7XF3	36897229	The structure of HLA-B*1501/BM58-66AF9	2022-03-31	2023-02-08	Zhao, Y.,Xiao, W.,Wu, Y.,Fan, W.,Li, L.,Yue, C.,Zhang, Q.,Zhang, D.,Yuan, X.,Yao, S.,Liu, S.,Li, M.,Wang, P.,Zhang, H.,Zhang, J.,Zhao, M.,Zheng, X.,Liu, W.,Gao, G.F.,Liu, W.J.	Parallel T Cell Immunogenic Regions in Influenza B and A Viruses with Distinct Nuclear Export Signal Functions: The Balance between Viral Life Cycle and Immune Escape.	J Immunol.	2023	210	1074	1085	
7Y0Y	36744476	Crystal structure of Pseudomonas aeruginosa PvrA (SeMet)	2022-06-06	2023-02-08	Pan, X.,Liang, H.,Zhao, X.,Zhang, Q.,Chen, L.,Yue, Z.,Yin, L.,Jin, Y.,Bai, F.,Cheng, Z.,Bartlam, M.,Wu, W.	Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa.	Nucleic Acids Res.	2023	51	2691	2708	
7YTT	36533407	Crystal structure of vaccinia virus G3/L5 sub-complex (SeMet-labeled, P21 space group)	2022-08-16	2023-02-08	Lin, S.,Yue, D.,Yang, F.,Chen, Z.,He, B.,Cao, Y.,Dong, H.,Li, J.,Zhao, Q.,Lu, G.	Crystal structure of vaccinia virus G3/L5 sub-complex reveals a novel fold with extended inter-molecule interactions conserved among orthopoxviruses.	Emerg Microbes Infect	2023	12	0	0	
7YTU	36533407	Crystal structure of vaccinia virus G3/L5 sub-complex (SeMet-labeled, P31 space group)	2022-08-16	2023-02-08	Lin, S.,Yue, D.,Yang, F.,Chen, Z.,He, B.,Cao, Y.,Dong, H.,Li, J.,Zhao, Q.,Lu, G.	Crystal structure of vaccinia virus G3/L5 sub-complex reveals a novel fold with extended inter-molecule interactions conserved among orthopoxviruses.	Emerg Microbes Infect	2023	12	0	0	
8H59	36779710	A fungal MAP kinase in complex with an inhibitor	2022-10-12	2023-02-08	Kong, Z.,Zhang, X.,Zhou, F.,Tang, L.,Chen, Y.,Li, S.,Zhang, X.,Kuai, L.,Su, W.,Cui, W.,Cai, J.,Wang, Y.,Yang, J.,Peng, Y.L.,Wang, D.,Liu, J.	Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi.	Mbio	2023	14	0	0	
7E45	34459191	Crystal structure of compound 7 bound to MIF	2021-02-10	2023-02-15	Yang, L.,Guo, D.,Fan, C.	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	J.Agric.Food Chem.	2021	69	10138	10150	
7E47	34459191	Crystal structure of compound 6 bound to MIF	2021-02-10	2023-02-15	Yang, L.,Guo, D.,Fan, C.	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	J.Agric.Food Chem.	2021	69	10138	10150	
7E49	34459191	Crystal structure of MIF bound to compound10	2021-02-11	2023-02-15	Yang, L.,Guo, D.,Fan, C.	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	J.Agric.Food Chem.	2021	69	10138	10150	
7E4A	34459191	Crystal structure of MIF bound to compound 13	2021-02-11	2023-02-15	Yang, L.,Guo, D.,Fan, C.	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	J.Agric.Food Chem.	2021	69	10138	10150	
7E4B	34459191	Crystal structure of MIF bound to compound 5	2021-02-11	2023-02-15	Yang, L.,Guo, D.,Fan, C.	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	J.Agric.Food Chem.	2021	69	10138	10150	
7E4C	34459191	Crystal structure of MIF bound to compound11	2021-02-11	2023-02-15	Yang, L.,Guo, D.,Fan, C.	Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.	J.Agric.Food Chem.	2021	69	10138	10150	
7V2U		The complex structure of SoBcmB and its product 2f	2021-08-09	2023-02-15	Wu, L.,Zhou, J.H.	The complex structure of SoBcmB and its product 2f	To Be Published	0	0	0	0	
7V2X		The complex structure of soBcmB and its substrate 1	2021-08-10	2023-02-15	Wu, L.,Zhou, J.H.	The crystal structure of SoBcmB and its side way substrate	To Be Published	0	0	0	0	
7V34		The complex structure of soBcmB and its product 1d	2021-08-10	2023-02-15	Wu, L.,Zhou, J.H.	The complex structure of SoBcmB and its side way product	To Be Published	0	0	0	0	
7V3O		The structure of Se-SoBcmB with Fe(II)and AKG	2021-08-10	2023-02-15	Wu, L.,Zhou, J.H.	The apo structure of SoBcmB with Fe(II)	To Be Published	0	0	0	0	
7V4X		Structure of cyclohexanone monooxygenase mutant from Acinetobacter calcoaceticus	2021-08-15	2023-02-15	Wu, Y.,Chen, Q.Q.,Chen, Q.,Geng, Q.,Zhang, Q.,Zheng, Y.C.,Zhao, C.,Zhang, Y.,Zhou, J.,Wang, B.,Xu, J.H.,Yu, H.L.	Precise regulation of the substrate selectivity of Baeyer-Villiger monooxygenase to minimize overoxidation of prazole sulfoxides.	CHINESE J CATAL	2023	51	157	167	
7WUP		The crystal structure of ApiI	2022-02-09	2023-02-15	Zhou, J.,Lu, J.	The crystal structure of ApiI	To Be Published	0	0	0	0	
7WUY		The crystal structure of FinI in complex with SAM and fischerin	2022-02-09	2023-02-15	Zhou, J.,Lu, J.	The crystal structure of FinI in complex with SAM and fischerin	To Be Published	0	0	0	0	
7XBM		Crystal Structure of cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238	2022-03-21	2023-02-15	Pan, Y.J.,Li, G.B.,Gao, X.,Li, S.Y.	Crystal Structure of cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238	Nat Commun	2023	0	0	0	
7XBN		Crystal Structure of YC-17-bound cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238	2022-03-21	2023-02-15	Pan, Y.J.,Li, G.B.,Gao, X.,Li, S.Y.	New mechanistic insight of cytochrome P450 PikC gained from site-specific mutagenesis by non-coding amino acids	Nat Commun	2023	0	0	0	
7XBO		Crystal Structure of 10-dml-bound cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238	2022-03-21	2023-02-15	Pan, Y.J.,Li, G.B.,Gao, X.,Li, S.Y.	New mechanistic insight of cytochrome P450 PikC gained from site-specific mutagenesis by non-coding amino acids	Nat Commun	2023	0	0	0	
7XHQ	36476046	Small-molecule Allosteric Regulation Mechanism of SHP2	2022-04-09	2023-02-15	Luo, Y.,Li, J.,Zong, Y.,Sun, M.,Zheng, W.,Zhu, J.,Liu, L.,Liu, B.	Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one.	J Enzyme Inhib Med Chem	2023	38	398	404	
7XRE		Crystal structure of DgpA	2022-05-10	2023-02-15	He, P.,Wang, S.,Li, S.,Liu, S.,Zhou, S.,Wang, J.,Tao, J.,Wang, D.,Wang, R.,Ma, W.	Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase.	Acta Pharm Sin B	2023	13	246	255	
7XRF		Crystal structaure of DgpB/C complex	2022-05-10	2023-02-15	He, P.,Wang, S.,Li, S.,Liu, S.,Zhou, S.,Wang, J.,Tao, J.,Wang, D.,Wang, R.,Ma, W.	Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase.	Acta Pharm Sin B	2023	13	246	255	
7YGL	36807980	Crystal Structure of the ring nuclease Sso2081 from Saccharolobus solfataricus in complex with A4>p cleavage intermediate	2022-07-11	2023-02-15	Du, L.,Zhang, D.,Luo, Z.,Lin, Z.	Molecular basis of stepwise cyclic tetra-adenylate cleavage by the type III CRISPR ring nuclease Crn1/Sso2081.	Nucleic Acids Res.	2023	51	2485	2495	
8HCZ	36896429	N-terminal domain structure of mycobacterium tuberculosis FadD23	2022-11-03	2023-02-15	Yan, M.,Cao, L.,Zhao, L.,Zhou, W.,Liu, X.,Zhang, W.,Rao, Z.	The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms.	Front Microbiol	2023	14	1090534	1090534	
8HD4	36896429	Full-length crystal structure of mycobacterium tuberculosis FadD23 in complex with AMPC16	2022-11-03	2023-02-15	Yan, M.,Cao, L.,Zhao, L.,Zhou, W.,Liu, X.,Zhang, W.,Rao, Z.	The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms.	Front Microbiol	2023	14	1090534	1090534	
8HDF	36896429	Full length crystal structure of mycobacterium tuberculosis FadD23 in complex with ANP and PLM	2022-11-04	2023-02-15	Yan, M.,Cao, L.,Zhao, L.,Zhou, W.,Liu, X.,Zhang, W.,Rao, Z.	The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms.	Front Microbiol	2023	14	1090534	1090534	
7V50		Structure of cyclohexanone monooxygenase mutant from Acinetobacter calcoaceticus	2021-08-16	2023-02-22	Wu, Y.,Chen, Q.Q.,Chen, Q.,Geng, Q.,Zhang, Q.,Zheng, Y.C.,Zhao, C.,Zhang, Y.,Zhou, J.,Wang, B.,Xu, J.H.,Yu, H.L.	Precise regulation of the substrate selectivity of Baeyer-Villiger monooxygenase to minimize overoxidation of prazole sulfoxides.	CHINESE J CATAL	2023	51	157	167	
7V51		BVMO_negative mutant D432V	2021-08-16	2023-02-22	Wu, Y.,Chen, Q.Q.,Chen, Q.,Geng, Q.,Zhang, Q.,Zheng, Y.C.,Zhao, C.,Zhang, Y.,Zhou, J.,Wang, B.,Xu, J.H.,Yu, H.L.	Precise regulation of the substrate selectivity of Baeyer-Villiger monooxygenase to minimize overoxidation of prazole sulfoxides.	CHINESE J CATAL	2023	51	157	167	
7WW2	37680460	Structure of an Isocytosine specific deaminase Vcz	2022-02-12	2023-02-22	Guo, W.,Li, X.,Fan, J.,Li, H.,Wen, Y.,Meng, C.,Chen, H.,Zhao, Z.,Zhang, Y.,Du, Y.,Wu, B.	Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy.	Iscience	2023	26	107672	107672	
7WW3		Crystal structure of MmIMP1-KH34 tandem domain	2022-02-12	2023-02-22	Li, X.J.,Wu, B.X.	Crystal structure of MmIMP1-KH34 tandem domain	To Be Published	0	0	0	0	
7WZC	36781028	An open conformation Form2 of switch II for RhoA GDP-bound state	2022-02-17	2023-02-22	Jiang, H.,Zu, S.,Lu, Y.,Sun, Z.,Adeerjiang, A.,Guo, Q.,Zhang, H.,Dong, C.,Wu, Q.,Ding, H.,Du, D.,Wang, M.,Liu, C.,Tang, Y.,Liang, Z.,Luo, C.	A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region.	J.Struct.Biol.	2023	215	107942	107942	
8H68	36764665	Crystal structure of Caenorhabditis elegans NMAD-1 in complex with NOG and Mg(II)	2022-10-16	2023-02-22	Shi, Y.,Yang, H.,Ding, J.	Caenorhabditis elegans NMAD-1 functions as a demethylase for actin.	J Mol Cell Biol	2023	15	0	0	
8HLO	36674928	Crystal structure of ASAP1-SH3 and MICAL1-PRM complex	2022-11-30	2023-02-22	Jia, X.,Lin, L.,Xu, S.,Li, L.,Wei, Z.,Yu, C.,Niu, F.	Crystal Structure of the SH3 Domain of ASAP1 in Complex with the Proline Rich Motif (PRM) of MICAL1 Reveals a Unique SH3/PRM Interaction Mode.	Int J Mol Sci	2023	24	0	0	
8I17	36801613	Structural basis for H2A-H2B recognitions by human Spt16	2023-01-12	2023-02-22	Li, Y.,Huang, H.	Structural basis for H2A-H2B recognitions by human Spt16.	Biochem.Biophys.Res.Commun.	2023	651	85	91	
7X5B	37025142	Crystal structure of RuvB	2022-03-04	2023-03-08	Zhang, X.,Zhou, Z.,Dai, L.,Chao, Y.,Liu, Z.,Huang, M.,Qu, Q.,Lin, Z.	Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa.	Front Plant Sci	2023	14	1139106	1139106	
7X63		SARS-CoV-2-Beta-RBD and BD-236-GWP/P-VK antibody complex	2022-03-06	2023-03-08	Shi, R.,Wang, Y.,Wu, Z.,Han, X.,Yan, J.	SARS-CoV-2-Beta-RBD and BD-236-GWP/P-VK antibody complex	To Be Published	0	0	0	0	
7X66		SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex	2022-03-06	2023-03-08	Shi, R.,Wang, Y.,Wu, Z.,Han, X.,Yan, J.	SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex	To Be Published	0	0	0	0	
7Y62	36749723	Crystal structure of human TFEB HLHLZ domain	2022-06-18	2023-03-22	Lin, Y.,Shi, Q.,Yang, G.,Shi, F.,Zhou, Y.,Wang, T.,Xu, P.,Li, P.,Liu, Z.,Sun, H.,Zhao, Z.,Ding, K.,Wang, Z.,Feng, H.,Yu, B.,Fang, P.,Wang, J.	A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
8H7H	36774655	The crystal structure of human abl1 kinase domain in complex with abl1-A-EBA	2022-10-20	2023-03-22	Chen, P.,Tang, G.,Zhu, C.,Sun, J.,Wang, X.,Xiang, M.,Huang, H.,Wang, W.,Li, L.,Zhang, Z.M.,Gao, L.,Yao, S.Q.	2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.	J.Am.Chem.Soc.	2023	0	0	0	
8HB8	36840714	Crystal structure of NAD-II riboswitch (single strand) with NMN	2022-10-27	2023-03-22	Peng, X.,Liao, W.,Lin, X.,Lilley, D.M.J.,Huang, L.	Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets.	Nucleic Acids Res.	2023	51	2904	2914	
8HB8	36840714	Crystal structure of NAD-II riboswitch (single strand) with NMN	2022-10-27	2023-03-22	Peng, X.,Liao, W.,Lin, X.,Lilley, D.M.J.,Huang, L.	Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets.	Nucleic Acids Res.	2023	51	2904	2914	
8HBA	36840714	Crystal structure of NAD-II riboswitch (single strand) with NAD	2022-10-27	2023-03-22	Peng, X.,Liao, W.,Lin, X.,Lilley, D.M.J.,Huang, L.	Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets.	Nucleic Acids Res.	2023	51	2904	2914	
8HBA	36840714	Crystal structure of NAD-II riboswitch (single strand) with NAD	2022-10-27	2023-03-22	Peng, X.,Liao, W.,Lin, X.,Lilley, D.M.J.,Huang, L.	Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets.	Nucleic Acids Res.	2023	51	2904	2914	
7W75	36912886	Crystal structure of the K. lactis Bre1 RBD in complex with Rad6, crystal form I	2021-12-03	2023-03-29	Shi, M.,Zhao, J.,Zhang, S.,Huang, W.,Li, M.,Bai, X.,Zhang, W.,Zhang, K.,Chen, X.,Xiang, S.	Structural basis for the Rad6 activation by the Bre1 N-terminal domain.	Elife	2023	12	0	0	
7W76	36912886	Crystal structure of the K. lactis Bre1 RBD in complex with Rad6, crystal form II	2021-12-03	2023-03-29	Shi, M.,Zhao, J.,Zhang, S.,Huang, W.,Li, M.,Bai, X.,Zhang, W.,Zhang, K.,Chen, X.,Xiang, S.	Structural basis for the Rad6 activation by the Bre1 N-terminal domain.	Elife	2023	12	0	0	
7XBI		The crystal structure of human TrkA kinase bound to the inhibitor	2022-03-21	2023-03-29	Wu, C.Y.,Wang, G.,Ouyang, L.	The crystal structure of human TrkA kinase bound to the inhibitor	To be published	0	0	0	0	
7XPR	36642179	Crystal structrue of SeMet-MtdL:GDP	2022-05-05	2023-03-29	Du, X.,Chu, X.,Liu, N.,Jia, X.,Peng, H.,Xiao, Y.,Liu, L.,Yu, H.,Li, F.,He, C.	Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.	J.Biol.Chem.	2023	299	102903	102903	
7XPS	36642179	Crystal structrue of MtdL:GDP:Mn	2022-05-05	2023-03-29	Du, X.,Chu, X.,Liu, N.,Jia, X.,Peng, H.,Xiao, Y.,Liu, L.,Yu, H.,Li, F.,He, C.	Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.	J.Biol.Chem.	2023	299	102903	102903	
7XPT	36642179	Crystal structrue of MtdL:GDP:Mn soaked with GDP-Glc	2022-05-05	2023-03-29	Du, X.,Chu, X.,Liu, N.,Jia, X.,Peng, H.,Xiao, Y.,Liu, L.,Yu, H.,Li, F.,He, C.	Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.	J.Biol.Chem.	2023	299	102903	102903	
7XPU	36642179	crystal structure of MtdL-S228A-His soaked GDP-Fucp and Mn	2022-05-05	2023-03-29	Du, X.,Chu, X.,Liu, N.,Jia, X.,Peng, H.,Xiao, Y.,Liu, L.,Yu, H.,Li, F.,He, C.	Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.	J.Biol.Chem.	2023	299	102903	102903	
7XPV	36642179	crysteal structure of MtdL-S228A-His soaked with GDP-Fucf and Mn	2022-05-05	2023-03-29	Du, X.,Chu, X.,Liu, N.,Jia, X.,Peng, H.,Xiao, Y.,Liu, L.,Yu, H.,Li, F.,He, C.	Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.	J.Biol.Chem.	2023	299	102903	102903	
7XT2		Crystal structure of TRIM72	2022-05-15	2023-03-29	Ma, Y.,Ding, L.,Li, Z.,Zhou, C.	Structural basis for TRIM72 oligomerization during membrane damage repair	Nat Commun	2023	14	1555	0	
8HL8	36642179	Crystal structrue of MtdL R257K mutant	2022-11-29	2023-03-29	Du, X.,Chu, X.,Liu, N.,Jia, X.,Peng, H.,Xiao, Y.,Liu, L.,Yu, H.,Li, F.,He, C.	Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn 2+ coordination and substrate binding.	J.Biol.Chem.	2023	299	102903	102903	
8IFO		Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter	2023-02-19	2023-03-29	Zhen, X.,Gan, Q.,Qu, L.,Dong, Y.,Pan, C.,Liu, J.,Wang, N.,Xu, T.	ERR gamma-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element	Biochem.Biophys.Res.Commun.	2023	656	16	22	
7X2N		Crystal structure of Diels-Alderase PycR1	2022-02-25	2023-04-05	Zhou, J.,Lu, J.	Crystal structure of hetero-Diels-Alderase PycR1	To Be Published	0	0	0	0	
7X2S		Crystal Structure of hetero-Diels-Alderase PycR1 in complex with Neosetophomone B and tropolone o-quinone methide	2022-02-26	2023-04-05	Zhou, J.,Lu, J.	Calcium-dependent glycosylated enzyme in the tandem hetero-Diels-Alder reaction	To Be Published	0	0	0	0	
7X2X		Crystal Structure of hetero-Diels-Alderase PycR1 in complex with 10-hydroxy-8E-humulene	2022-02-26	2023-04-05	Zhou, J.,Lu, J.	Calcium-dependent glycosylated enzyme in the tandem hetero-Diels-Alder reaction	To Be Published	0	0	0	0	
7X36		Crystal Structure of hetero-Diels-Alderase EupfF	2022-02-28	2023-04-05	Zhou, J.,Lu, J.	Calcium-dependent glycosylated enzyme in the tandem hetero-Diels-Alder reaction	To Be Published	0	0	0	0	
7X4Y	36358099	Crystal structure of Bacteroides thetaiotaomicron glutamate decarboxylase BTGAD-PLP-GABA complex	2022-03-03	2023-04-05	Liu, S.,Wen, B.,Du, G.,Wang, Y.,Ma, X.,Yu, H.,Zhang, J.,Fan, S.,Zhou, H.,Xin, F.	Coordinated regulation of Bacteroides thetaiotaomicron glutamate decarboxylase activity by multiple elements under different pH.	Food Chem	2023	403	134436	134436	
7XDU		TtherAmDH-NAD+	2022-03-28	2023-04-05	Chen, C.,Qian, Y.Y.,Pan, J.,Xu, J.H.,Bai, Y.P.	Stereoselective synthesis of chiral lactams via an engineered natural amine dehydrogenase.	To Be Published	0	0	0	0	
7XR9	36815035	Crystal structure of DgpA with glucose	2022-05-09	2023-04-05	He, P.,Wang, S.,Li, S.,Liu, S.,Zhou, S.,Wang, J.,Tao, J.,Wang, D.,Wang, R.,Ma, W.	Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C -glycoside cleaving enzyme and an O - to C -glycoside isomerase.	Acta Pharm Sin B	2023	13	246	255	
8IGN	38553607	Crystal structure of SARS-CoV-2 main protease in complex with RAY1216	2023-02-21	2023-04-05	Chen, X.,Huang, X.,Ma, Q.,Kuzmic, P.,Zhou, B.,Zhang, S.,Chen, J.,Xu, J.,Liu, B.,Jiang, H.,Zhang, W.,Yang, C.,Wu, S.,Huang, J.,Li, H.,Long, C.,Zhao, X.,Xu, H.,Sheng, Y.,Guo, Y.,Niu, C.,Xue, L.,Xu, Y.,Liu, J.,Zhang, T.,Spencer, J.,Zhu, Z.,Deng, W.,Chen, X.,Chen, S.H.,Zhong, N.,Xiong, X.,Yang, Z.	Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir.	Nat Microbiol	2024	9	1075	1088	
8IGO	38553607	Crystal structure of apo SARS-CoV-2 main protease	2023-02-21	2023-04-05	Chen, X.,Huang, X.,Ma, Q.,Kuzmic, P.,Zhou, B.,Zhang, S.,Chen, J.,Xu, J.,Liu, B.,Jiang, H.,Zhang, W.,Yang, C.,Wu, S.,Huang, J.,Li, H.,Long, C.,Zhao, X.,Xu, H.,Sheng, Y.,Guo, Y.,Niu, C.,Xue, L.,Xu, Y.,Liu, J.,Zhang, T.,Spencer, J.,Zhu, Z.,Deng, W.,Chen, X.,Chen, S.H.,Zhong, N.,Xiong, X.,Yang, Z.	Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir.	Nat Microbiol	2024	9	1075	1088	
7X8X		structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease	2022-03-15	2023-04-12	Yang, Y.,Zhao, N.,Xu, X.,Zhou, Y.,Luo, B.,Zhang, J.,Sui, J.,Huang, J.,Qiu, Z.,Zhang, X.,Zeng, J.,Bai, L.,Bao, R.,Luo, Y.	Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors	J.Med.Chem.	2023	66	16597	16614	
7XAD	37100904	Crystal strucutre of PD-L1 and DBL2_02 designed protein binder	2022-03-17	2023-04-12	Gainza, P.,Wehrle, S.,Van Hall-Beauvais, A.,Marchand, A.,Scheck, A.,Harteveld, Z.,Buckley, S.,Ni, D.,Tan, S.,Sverrisson, F.,Goverde, C.,Turelli, P.,Raclot, C.,Teslenko, A.,Pacesa, M.,Rosset, S.,Georgeon, S.,Marsden, J.,Petruzzella, A.,Liu, K.,Xu, Z.,Chai, Y.,Han, P.,Gao, G.F.,Oricchio, E.,Fierz, B.,Trono, D.,Stahlberg, H.,Bronstein, M.,Correia, B.E.	De novo design of protein interactions with learned surface fingerprints.	Nature	2023	617	176	184	
7XP0	36475801	Crystal structure of PmiR from Pseudomonas aeruginosa	2022-05-02	2023-04-12	Cui, G.,Zhang, Y.,Xu, X.,Liu, Y.,Li, Z.,Wu, M.,Liu, J.,Gan, J.,Liang, H.	PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa.	Sci Adv	2022	8	0	0	
7XP1	36475801	Crystal structure of PmiR from Pseudomonas aeruginosa	2022-05-02	2023-04-12	Cui, G.,Zhang, Y.,Xu, X.,Liu, Y.,Li, Z.,Wu, M.,Liu, J.,Gan, J.,Liang, H.	PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa.	Sci Adv	2022	8	0	0	
8GTJ	36991125	Crystal structure of IpaH7.8-LRR and GSDMB isoform-4 complex	2022-09-08	2023-04-12	Zhong, X.,Zeng, H.,Zhou, Z.,Su, Y.,Cheng, H.,Hou, Y.,She, Y.,Feng, N.,Wang, J.,Shao, F.,Ding, J.	Structural mechanisms for regulation of GSDMB pore-forming activity.	Nature	2023	616	598	605	
8I27	37070195	E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface	2023-01-14	2023-04-12	Xiang, M.,Xia, K.,Chen, B.,Luo, Z.,Yu, Y.,Jiang, L.,Zhou, H.	An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.	Nucleic Acids Res.	2023	51	4637	4649	
8I2A	37070195	E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface	2023-01-14	2023-04-12	Xiang, M.,Xia, K.,Chen, B.,Luo, Z.,Yu, Y.,Jiang, L.,Zhou, H.	An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.	Nucleic Acids Res.	2023	51	4637	4649	
8I2C	37070195	E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface	2023-01-14	2023-04-12	Xiang, M.,Xia, K.,Chen, B.,Luo, Z.,Yu, Y.,Jiang, L.,Zhou, H.	An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.	Nucleic Acids Res.	2023	51	4637	4649	
8I2L	37070195	E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface	2023-01-14	2023-04-12	Xiang, M.,Xia, K.,Chen, B.,Luo, Z.,Yu, Y.,Jiang, L.,Zhou, H.	An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.	Nucleic Acids Res.	2023	51	4637	4649	
7XIN		Crystal structure of DODC from Pseudomonas	2022-04-13	2023-04-19	Li, X.,Zhou, Y.L.,Liao, L.J.,Liu, X.K.,Liu, B.,Guo, Y.,Feng, Z.,Sun, D.Y.,Zeng, Z.X.	Crystal structure of DODC from Pseudomonas	To Be Published	0	0	0	0	
7XIO		Crystal structure of TYR from Ralstonia	2022-04-13	2023-04-19	Sun, D.Y.,Cui, P.P.,Liao, L.J.,Liu, X.K.,Liu, B.,Guo, Y.,Feng, Z.,Zhang, J.,Li, X.,Zeng, Z.X.	Crystal structure of TYR from Ralstonia	To Be Published	0	0	0	0	
7XRQ	36525499	The Catalytic Core Structure of Cystathionine beta-Synthase from Candida albicans	2022-05-11	2023-04-19	Chang, W.,Zhang, M.,Jin, X.,Zhang, H.,Zheng, H.,Zheng, S.,Qiao, Y.,Yu, H.,Sun, B.,Hou, X.,Lou, H.	Inhibition of fungal pathogenicity by targeting the H 2 S-synthesizing enzyme cystathionine beta-synthase.	Sci Adv	2022	8	0	0	
8H02	37036976	Crystal structure of Synechococcus elongatus PCC 7942 RNA polymerase SI3-tail	2022-09-27	2023-04-19	Shen, L.,Lai, G.,You, L.,Shi, J.,Wu, X.,Puiu, M.,Gu, Z.,Feng, Y.,Yuzenkova, Y.,Zhang, Y.	An SI3-sigma arch stabilizes cyanobacteria transcription initiation complex.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
8HEF	36997073	The Crystal structure of deuterated S-217622 (Ensitrelvir) bound to the main protease (3CLpro/Mpro) of SARS-CoV-2	2022-11-08	2023-04-19	Yang, Y.,Cao, L.,Yan, M.,Zhou, J.,Yang, S.,Xu, T.,Huang, S.,Li, K.,Zhou, Q.,Li, G.,Zhu, Y.,Cong, F.,Zhang, H.,Guo, D.,Li, Y.,Zhang, X.	Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2.	Antiviral Res.	2023	213	105586	105586	
8HO1	37083030	Crystal structure of cytochrome P450 NasF5053 mutant F387G	2022-12-09	2023-04-19	Sun, C.,Ma, B.D.,Li, G.,Tian, W.,Yang, L.,Peng, H.,Lin, Z.,Deng, Z.,Kong, X.D.,Qu, X.	Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8INH	37123177	ZjOGT3, flavonoid 7,4'-di-O-glycosyltransferase	2023-03-09	2023-04-19	Wang, Z.L.,Wei, W.,Wang, H.D.,Zhou, J.J.,Wang, H.T.,Chen, K.,Wang, R.S.,Li, F.D.,Qiao, X.,Zhou, H.,Liang, Y.,Ye, M.	Functional characterization, structural basis, and regio-selectivity control of a promiscuous flavonoid 7,4'-di- O -glycosyltransferase from Ziziphus jujuba var. spinosa.	Chem Sci	2023	14	4418	4425	
7WKO	37094126	ICP1 Csy1-2 complex	2022-01-10	2023-04-26	Zhang, M.,Peng, R.,Peng, Q.,Liu, S.,Li, Z.,Zhang, Y.,Song, H.,Yang, J.,Xing, X.,Wang, P.,Qi, J.,Gao, G.F.	Mechanistic insights into DNA binding and cleavage by a compact type I-F CRISPR-Cas system in bacteriophage.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
7WKP	37094126	ICP1 Csy4	2022-01-10	2023-04-26	Zhang, M.,Peng, R.,Peng, Q.,Liu, S.,Li, Z.,Zhang, Y.,Song, H.,Yang, J.,Xing, X.,Wang, P.,Qi, J.,Gao, G.F.	Mechanistic insights into DNA binding and cleavage by a compact type I-F CRISPR-Cas system in bacteriophage.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
7XIK		SARS-CoV-2-Omicron-RBD and B38-GWP/P-VK antibody complex	2022-04-13	2023-04-26	Shi, R.,Wang, Y.,Wu, Z.,Han, X.,Yan, J.	SARS-CoV-2-Omicron-RBD and B38-GWP/P-VK antibody complex	To Be Published	0	0	0	0	
7XIL		SARS-CoV-2-Beta-RBD and B38-GWP/P-VK antibody complex	2022-04-13	2023-04-26	Shi, R.,Wang, Y.,Wu, Z.,Han, X.,Yan, J.	SARS-CoV-2-Beta-RBD and B38-GWP/P-VK antibody complex	To Be Published	0	0	0	0	
8H9H	37013936	Crystal structure of ZBTB7A in complex with GACCC-containing sequence	2022-10-25	2023-04-26	Yang, Y.,Xiao, L.,Xue, Y.,Idris, M.O.,Liu, J.,Pei, D.,Shi, Y.,Liao, B.,Li, F.	ZBTB7A regulates primed-to-naive transition of pluripotent stem cells via recognition of the PNT-associated sequence by zinc fingers 1-2 and recognition of gamma-globin -200 gene element by zinc fingers 1-4.	Febs J.	2023	290	3896	3909	
8HNY	37083030	Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 5FCWP	2022-12-09	2023-04-26	Sun, C.,Ma, B.D.,Li, G.,Tian, W.,Yang, L.,Peng, H.,Lin, Z.,Deng, Z.,Kong, X.D.,Qu, X.	Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8IQU	37522751	Structure of MtbFadD23 with PhU-AMS	2023-03-17	2023-04-26	Yan, M.,Ma, M.,Chen, R.,Cao, Y.,Zhang, W.,Liu, X.	Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis.	Acta Crystallogr.,Sect.F	2023	79	208	216	
7XNJ		Stress Response Facilitator A SrfA	2022-04-28	2023-05-03	Lou, X.,Zhang, Q.,Bartlam, M.	Stress Response Facilitator A SfrA	To Be Published	0	0	0	0	
7YQB	36216242	Functional and Structural Characterization of Norovirus GII.6 in Recognizing Histo-blood Group Antigens	2022-08-05	2023-05-03	Cong, X.,Li, H.B.,Sun, X.M.,Qi, J.X.,Zhang, Q.,Duan, Z.J.,Xu, Y.,Liu, W.L.	Functional and structural characterization of Norovirus GII.6 in recognizing histo-blood group antigens.	Virol Sin	2023	38	56	65	
8IGL	37191520	Crystal structure of a major fragment of the ASFV inner capsid protein p150	2023-02-20	2023-05-03	Li, H.,Liu, Q.,Shao, L.,Xiang, Y.	Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid.	J.Virol.	2023	97	0	0	
8HN9	36896611	Human SIRT3 Recognizing CCNE2K348la peptide	2022-12-07	2023-05-10	Jin, J.,Bai, L.,Wang, D.,Ding, W.,Cao, Z.,Yan, P.,Li, Y.,Xi, L.,Wang, Y.,Zheng, X.,Wei, H.,Ding, C.,Wang, Y.	SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.	Embo Rep.	2023	24	0	0	
7XC8		Crystal structure of cotton alpha-like expansin GhEXLA1	2022-03-23	2023-05-17	Zhao, F.,Men, S.,Xue, Y.,Tu, L.L.,Yin, P.,Zhang, X.L.	Crystal structure of cotton alpha-like expansin GhEXLA1	To Be Published	0	0	0	0	
7XNM		Structure of porcine dipeptidyl peptidase 4 inhibitory peptide complex	2022-04-29	2023-05-17	Li, W.Y.,Cao, M.J.	Structure of porcine dipeptidyl peptidase 4 inhibitory peptide complex	To Be Published	0	0	0	0	
7XPO	37474494	Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD/UDP-Glc	2022-05-05	2023-05-17	Zhou, Y.,Zhang, T.,Wang, X.,Wu, W.,Xing, J.,Li, Z.,Qiao, X.,Zhang, C.,Wang, X.,Wang, G.,Li, W.,Bai, S.,Li, Z.,Suo, Y.,Wang, J.,Niu, Y.,Zhang, J.,Lan, C.,Hu, Z.,Li, B.,Zhang, X.,Wang, W.,Galbraith, D.W.,Chen, Y.,Guo, S.,Song, C.P.	A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis.	Nat Commun	2023	14	4384	4384	
7XPQ	37474494	Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD/UDP-GlcNAc	2022-05-05	2023-05-17	Zhou, Y.,Zhang, T.,Wang, X.,Wu, W.,Xing, J.,Li, Z.,Qiao, X.,Zhang, C.,Wang, X.,Wang, G.,Li, W.,Bai, S.,Li, Z.,Suo, Y.,Wang, J.,Niu, Y.,Zhang, J.,Lan, C.,Hu, Z.,Li, B.,Zhang, X.,Wang, W.,Galbraith, D.W.,Chen, Y.,Guo, S.,Song, C.P.	A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis.	Nat Commun	2023	14	4384	4384	
7XQX		Crystal structure of T2R-TTL-27a complex	2022-05-09	2023-05-17	Lun, T.,Yuxi, W.	Crystal structure of T2R-TT complex	To Be Published	0	0	0	0	
7XQY		Crystal structure of T2R-TTL-15 complex	2022-05-09	2023-05-17	Lun, T.,Chengyong, W.	Crystal structure of T2R-TTL-15 complex	To Be Published	0	0	0	0	
7XR0		Crystal structure of T2R-TTL-27a complex	2022-05-09	2023-05-17	Lun, T.,ChengYong, W.	Crystal structure of T2R-TTL-27a complex	To Be Published	0	0	0	0	
7XR1		Crystal structure of T2R-TTL-3a complex	2022-05-09	2023-05-17	Lun, T.,ChengYong, W.	Crystal structure of T2R-TTL-3a complex	To Be Published	0	0	0	0	
7XS0	37301353	Trimer structure of HtrA from Helicobacter pylori bound with a tripeptide	2022-05-12	2023-05-17	Cui, L.,Shi, X.,Li, H.,Wang, S.,Guo, L.,Lan, Z.,Dai, Y.,Zhang, Q.,Wu, Y.,Liu, W.	Crystal structures and solution conformations of HtrA from Helicobacter pylori reveal pH-dependent oligomeric conversion and conformational rearrangements.	Int.J.Biol.Macromol.	2023	243	125274	125274	
7XS2	37301353	Monomer structure of HtrA from Helicobacter pylori	2022-05-12	2023-05-17	Cui, L.,Shi, X.,Li, H.,Wang, S.,Guo, L.,Lan, Z.,Dai, Y.,Zhang, Q.,Wu, Y.,Liu, W.	Crystal structures and solution conformations of HtrA from Helicobacter pylori reveal pH-dependent oligomeric conversion and conformational rearrangements.	Int.J.Biol.Macromol.	2023	243	125274	125274	
7XTY		Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide	2022-05-18	2023-05-17	Jing, L.Q.,Sun, X.N.,Ma, W.H.,Zhou, W.J.,Wu, D.L.	Targeting PTPN13 with 11 amino acid peptides of C-terminal APC prevents immune evasion of colorectal cancer	to be published	0	0	0	0	
8GP6	36757688	Structure of the vaccinia virus A16/G9 sub-complex from the orthopoxvirus entry-fusion complex	2022-08-25	2023-05-17	Yang, F.,Lin, S.,Chen, Z.,Yue, D.,Yang, M.,He, B.,Cao, Y.,Dong, H.,Li, J.,Zhao, Q.,Lu, G.	Structural basis of poxvirus A16/G9 binding for sub-complex formation.	Emerg Microbes Infect	2023	12	2179351	2179351	
8H3J		Crystal Structure of Pathogenesis-related Protein HcPR10 from Halostachys caspica in complex with trans-Zeatin-riboside	2022-10-08	2023-05-17	Feng, Y.,Ren, Y.,Zhang, H.,Heng, Y.,Wang, Z.,Wang, Y.	Halostachys caspica pathogenesis-related protein 10 acts as a cytokinin reservoir to regulate plant growth and development	Front Plant Sci	2023	14	1116985	0	
8HN6	37234155	Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD	2022-12-07	2023-05-17	Wang, Z.,Li, D.,Chen, Y.,Sun, Y.,Jin, C.,Hu, C.,Feng, Y.,Su, J.,Ren, L.,Hao, Y.,Wang, S.,Zhu, M.,Liu, Y.,Qi, J.,Zhu, B.,Shao, Y.	Characterization of RBD-specific cross-neutralizing antibodies responses against SARS-CoV-2 variants from COVID-19 convalescents.	Front Immunol	2023	14	1160283	1160283	
8HN7	37234155	Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD	2022-12-07	2023-05-17	Wang, Z.,Li, D.,Chen, Y.,Sun, Y.,Jin, C.,Hu, C.,Feng, Y.,Su, J.,Ren, L.,Hao, Y.,Wang, S.,Zhu, M.,Liu, Y.,Qi, J.,Zhu, B.,Shao, Y.	Characterization of RBD-specific cross-neutralizing antibodies responses against SARS-CoV-2 variants from COVID-19 convalescents.	Front Immunol	2023	14	1160283	1160283	
7VF6	37308591	The crystal structure of PurZ0	2021-09-10	2023-05-24	Tong, Y.,Wu, X.,Liu, Y.,Chen, H.,Zhou, Y.,Jiang, L.,Li, M.,Zhao, S.,Zhang, Y.	Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage.	Nat Microbiol	2023	8	1330	1338	
7XPP	37474494	Crystal Structure of UDP-Glc/GlcNAc 4-Epimerase with NAD	2022-05-05	2023-05-24	Zhou, Y.,Zhang, T.,Wang, X.,Wu, W.,Xing, J.,Li, Z.,Qiao, X.,Zhang, C.,Wang, X.,Wang, G.,Li, W.,Bai, S.,Li, Z.,Suo, Y.,Wang, J.,Niu, Y.,Zhang, J.,Lan, C.,Hu, Z.,Li, B.,Zhang, X.,Wang, W.,Galbraith, D.W.,Chen, Y.,Guo, S.,Song, C.P.	A maize epimerase modulates cell wall synthesis and glycosylation during stomatal morphogenesis.	Nat Commun	2023	14	4384	4384	
7Y4X	37130844	Crystal structure of sDscam Ig1 domain, isoform alpha7	2022-06-16	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y54	37130844	Crystal structure of sDscam Ig1 domain, isoform alpha1	2022-06-16	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y5J	37130844	Crystal structure of sDscam Ig1 domain, isoform alpha1v7	2022-06-17	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y5R	37130844	Crystal structure of sDscam FNIII2 domain, isoform alpha7	2022-06-17	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y6E	37130844	Crystal structure of sDscam FNIII23 domains, isoform Beta2v6	2022-06-20	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y6O	37130844	Crystal structure of sDscam Ig1-3 domains, isoform alpha25	2022-06-21	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y73	37130844	Crystal structure of sDscam Ig1 domain, isoform beta3v7	2022-06-21	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y8H	37130844	Crystal structure of sDscam FNIII1 domain, isoform alpha7	2022-06-23	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y8I	37130844	Crystal structure of sDscam FNIII3 domain, isoform alpha7	2022-06-24	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y8S	37130844	Crystal structure of sDscam FNIII1-3 domains, isoform beta2v6	2022-06-24	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y95	37130844	Crystal structure of sDscam Ig1 domain, isoform beta6v2	2022-06-24	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7Y9A	37130844	Crystal structure of sDscam Ig1-2 domains, isoform beta2v6	2022-06-24	2023-05-24	Cheng, J.,Yu, Y.,Wang, X.,Zheng, X.,Liu, T.,Hu, D.,Jin, Y.,Lai, Y.,Fu, T.M.,Chen, Q.	Structural basis for the self-recognition of sDSCAM in Chelicerata.	Nat Commun	2023	14	2522	2522	
7YPM	36300723	Crystal structure of transaminase CC1012 complexed with PLP and L-alanine	2022-08-03	2023-05-24	Yang, L.,Zhang, K.,Xu, M.,Xie, Y.,Meng, X.,Wang, H.,Wei, D.	Mechanism-Guided Computational Design of omega-Transaminase by Reprograming of High-Energy-Barrier Steps.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7YPN	36300723	Crystal structure of transaminase CC1012 mutant M9 complexed with PLP	2022-08-03	2023-05-24	Yang, L.,Zhang, K.,Xu, M.,Xie, Y.,Meng, X.,Wang, H.,Wei, D.	Mechanism-Guided Computational Design of omega-Transaminase by Reprograming of High-Energy-Barrier Steps.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
8GPH		Crystal structure of protease 3C (C160A mutant) from Seneca Valley Virus	2022-08-26	2023-05-24	Zhao, H.F.,Zhang, H.	Crystal structure of protease 3C (C160A mutant) from Seneca Valley Virus	To Be Published	0	0	0	0	
7VZT		A human neutralizing antibody targeting SARS-CoV-2 RBD	2021-11-16	2023-05-31	Wang, F.Z.,Tan, X.W.,Shi, R.	GH12, glycosylation function	To Be Published	0	0	0	0	
7XEG		SARS-CoV-2-Beta-RBD and CB6-092-Fab complex	2022-03-31	2023-05-31	Wang, Y.,Feng, Y.	SARS-CoV-2-Beta-RBD and CB6-092-Fab complex	To Be Published	0	0	0	0	
7XLZ		Structure of siderophore-interacting protein from Vibrio anguillarum	2022-04-23	2023-05-31	Ma, Q.,Liu, C.,Han, Y.	Structure of siderophore-interacting protein from Vibrio anguillarum	To Be Published	0	0	0	0	
7XMW	35512461	Crystal structure of anti-CRISPR protein AcrVIA2	2022-04-27	2023-05-31	Song, G.,Li, X.,Wang, Z.,Dong, C.,Xie, X.,Yan, X.	Structure of AcrVIA2 and its binding mechanism to CRISPR-Cas13a.	Biochem.Biophys.Res.Commun.	2022	612	84	90	
7XQE		Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039	2022-05-07	2023-05-31	Wu, X.,Li, C.,Zhang, Y.,Xu, Y.	Crystal Structure of human RORgamma LBD in complex with compound XY039	To Be Published	0	0	0	0	
7XWU		Ketoreductase CpKR mutant - M1	2022-05-27	2023-05-31	Chen, C.,Zheng, Y.C.,Pan, J.,Xu, J.H.	Computational Redesign of a robust Ketoreductase for Asymmetric Synthesis of Enantiopure diltiazem precursor.	To Be Published	0	0	0	0	
8HF9	37385996	The structure of chitin deacetylase Pst_13661 from Puccinia striiformis f. sp. tritici	2022-11-10	2023-05-31	Liu, L.,Xia, Y.,Li, Y.,Zhou, Y.,Su, X.,Yan, X.,Wang, Y.,Liu, W.,Cheng, H.,Wang, Y.,Yang, Q.	Inhibition of chitin deacetylases to attenuate plant fungal diseases.	Nat Commun	2023	14	3857	3857	
7FEX		Crystal structure of Sus scrofa Schlafen11 N-terminal domain (2.69 A)	2021-07-22	2023-06-07	Hou, P.,Hao, W.,Qin, B.,Li, M.,Zhao, R.,Cui, S.	Structural and biochemical characterization of Schlafen11 N-terminal domain.	Nucleic Acids Res.	2023	0	0	0	
7W7O		The crystal structure of human Calpain-1 protease core in complex with 14a	2021-12-06	2023-06-07	Zhao, Y.,Zhao, J.,Shao, M.,Yang, H.,Rao, Z.	The crystal structure of human Calpain-1 protease core  in complex with 14a	To Be Published	0	0	0	0	
7XRB		human STK19 dimer	2022-05-10	2023-06-07	Li, Y.,Sun, Q.	human STK19 dimer	To Be Published	0	0	0	0	
7XYJ		Structure of WSSV thymidylate synthase in complex with dUMP	2022-06-01	2023-06-07	Ma, Q.,Liu, C.,Zang, K.	Structure of WSSV thymidylate synthase in complex with dUMP	To Be Published	0	0	0	0	
7XYK		Structure of WSSV thymidylate synthase in complex with dUMP and raltitrexed	2022-06-01	2023-06-07	Ma, Q.,Liu, C.,Zang, K.	Structure of WSSV thymidylate synthase in complex with dUMP and raltitrexed	To Be Published	0	0	0	0	
7XYO	37466996	Crystal Structure of a M61 aminopeptidase family member from Myxococcus fulvus	2022-06-02	2023-06-07	Wang, X.,Chen, X.,Wang, Z.J.,Zhuang, M.,Zhong, L.,Fu, C.,Garcia, R.,Muller, R.,Zhang, Y.,Yan, J.,Wu, D.,Huo, L.	Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity.	J.Am.Chem.Soc.	2023	145	16924	16937	
7XZG		High resolution crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase from Candida albicans complexed with NAD+	2022-06-02	2023-06-07	Cao, H.,Meng, J.,Ren, Y.,Wan, J.	High resolution crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase from Candida albicans complexed with NAD+	To Be Published	0	0	0	0	
7YH9	37209449	Crystal structure of IMP-1 MBL in complex with 3-(4-benzyl-1H-1,2,3-triazol-1-yl)phthalic acid	2022-07-13	2023-06-07	Yan, Y.H.,Ding, H.S.,Zhu, K.R.,Mu, B.S.,Zheng, Y.,Huang, M.Y.,Zhou, C.,Li, W.F.,Wang, Z.,Wu, Y.,Li, G.B.	Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2023	257	115473	115473	
7YHA	37209449	Crystal structure of IMP-1 MBL in complex with (3-(4-(p-tolyl)-1H-1,2,3-triazol-1-yl)benzyl)phosphonic acid	2022-07-13	2023-06-07	Yan, Y.H.,Ding, H.S.,Zhu, K.R.,Mu, B.S.,Zheng, Y.,Huang, M.Y.,Zhou, C.,Li, W.F.,Wang, Z.,Wu, Y.,Li, G.B.	Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2023	257	115473	115473	
7YHB	37209449	Crystal structure of VIM-2 MBL in complex with (2-(4-phenyl-1H-1,2,3-triazol-1-yl)benzyl)phosphonic acid	2022-07-13	2023-06-07	Yan, Y.H.,Ding, H.S.,Zhu, K.R.,Mu, B.S.,Zheng, Y.,Huang, M.Y.,Zhou, C.,Li, W.F.,Wang, Z.,Wu, Y.,Li, G.B.	Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2023	257	115473	115473	
7YHC	37209449	Crystal structure of VIM-2 MBL in complex with 3-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)phthalic acid	2022-07-13	2023-06-07	Yan, Y.H.,Ding, H.S.,Zhu, K.R.,Mu, B.S.,Zheng, Y.,Huang, M.Y.,Zhou, C.,Li, W.F.,Wang, Z.,Wu, Y.,Li, G.B.	Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2023	257	115473	115473	
7YHD	37209449	Crystal structure of VIM-2 MBL in complex with 3-(4-(4-(2-aminoethoxy)phenyl)-1H-1,2,3-triazol-1-yl)phthalic acid	2022-07-13	2023-06-07	Yan, Y.H.,Ding, H.S.,Zhu, K.R.,Mu, B.S.,Zheng, Y.,Huang, M.Y.,Zhou, C.,Li, W.F.,Wang, Z.,Wu, Y.,Li, G.B.	Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors.	Eur.J.Med.Chem.	2023	257	115473	115473	
7YQG	36216242	Functional and Structural Characterization of Norovirus GII.6 in Recognizing Histo-blood Group Antigens	2022-08-06	2023-06-07	Cong, X.,Li, H.B.,Sun, X.M.,Qi, J.X.,Zhang, Q.,Duan, Z.J.,Xu, Y.,Liu, W.L.	Functional and structural characterization of Norovirus GII.6 in recognizing histo-blood group antigens.	Virol Sin	2023	38	56	65	
7X79		The crystal structure of human Calpain-1 protease core in complex with 14b	2022-03-09	2023-06-14	Zhao, Y.,Zhao, J.,Shao, M.,Yang, H.,Rao, Z.	The crystal structure of human Calpain-1 protease core  in complex with 14a	To Be Published	0	0	0	0	
7XUT		Crystal structure of RPA70N-WRN fusion	2022-05-19	2023-06-14	Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C.	Structural characterization of human RPA70N association with DNA damage response proteins.	Elife	2023	12	0	0	
7XUV		Crystal structure of RPA70N-RMI1 fusion	2022-05-20	2023-06-14	Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C.	Structural characterization of human RPA70N association with DNA damage response proteins.	Elife	2023	12	0	0	
7XV4		Crystal structure of RPA70N-ATRIP fusion	2022-05-20	2023-06-14	Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C.	Structural characterization of human RPA70N association with DNA damage response proteins.	Elife	2023	12	0	0	
7Y16	38180340	Crystal structure of rRNA-processing protein Las1	2022-06-07	2023-06-14	Chen, J.,Chen, H.,Li, S.,Lin, X.,Hu, R.,Zhang, K.,Liu, L.	Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery.	Elife	2024	12	0	0	
7Y18	38180340	Crystal structure of ribosomal ITS2 pre-rRNA processing complex from Saccharomyces cerevisiae	2022-06-07	2023-06-14	Chen, J.,Chen, H.,Li, S.,Lin, X.,Hu, R.,Zhang, K.,Liu, L.	Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery.	Elife	2024	12	0	0	
7Y3H		Crystal Structure of Diels-Alderase ApiI in complex with SAM and product	2022-06-10	2023-06-14	Zhou, J.H.,Lu, J.Y.	Crystal Structure of Diels-Alderase ApiI in complex with SAM and product	To Be Published	0	0	0	0	
7YFK	37291126	The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin	2022-07-08	2023-06-14	Fan, S.,Yan, Y.,Xia, Y.,Zhou, Z.,Luo, L.,Zhu, M.,Han, Y.,Yao, D.,Zhang, L.,Fang, M.,Peng, L.,Yu, J.,Liu, Y.,Gao, X.,Guan, H.,Li, H.,Wang, C.,Wu, X.,Zhu, H.,Cao, Y.,Huang, C.	Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.	Nat Commun	2023	14	3368	3368	
7YLT		Structure of a bacteria protein	2022-07-26	2023-06-14	Zhang, H.,Ma, Y.J.,Yu, G.M.,Li, X.Z.	Structure of a bacteria protein	To Be Published	0	0	0	0	
8HP5		Crystal structure of (S)-2-haloacid dehalogenase	2022-12-12	2023-06-21	Xu, X.,Yang, Q.,Wang, L.,Zheng, J.,Gu, Y.,Xing, X.W.,Zhou, J.	Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening	Catalysis Science And Technolo	2023	0	0	0	
8HP6		Crystal structure of (S)-2-haloacid dehalogenase D12A mutant	2022-12-12	2023-06-21	Xu, X.,Yang, Q.,Wang, L.,Zheng, J.,Gu, Y.,Xing, X.W.,Zhou, J.	Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening	Catalysis Science And Technolo	2023	0	0	0	
8I1M	37207644	Crystal structure of oxidated APSK1 domain from human PAPSS1 in complex with APS and ADP	2023-01-13	2023-06-28	Zhang, L.,Song, W.,Li, T.,Mu, Y.,Zhang, P.,Hu, J.,Lin, H.,Zhang, J.,Gao, H.,Zhang, L.	Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.	Structure	2023	31	826	0	
8I1N	37207644	Crystal structure of APSK2 domain from human PAPSS2 in complex with endogenous APS and ADP	2023-01-13	2023-06-28	Zhang, L.,Song, W.,Li, T.,Mu, Y.,Zhang, P.,Hu, J.,Lin, H.,Zhang, J.,Gao, H.,Zhang, L.	Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.	Structure	2023	31	826	0	
7XVK	37369204	Modularity of Phytophthora effectors enables host mimicry of a principal phosphatase	2022-05-24	2023-07-05	Li, H.,Wang, J.,Kuan, T.A.,Tang, B.,Feng, L.,Wang, J.,Cheng, Z.,Sklenar, J.,Derbyshire, P.,Hulin, M.,Li, Y.,Zhai, Y.,Hou, Y.,Menke, F.L.H.,Wang, Y.,Ma, W.	Pathogen protein modularity enables elaborate mimicry of a host phosphatase.	Cell	2023	186	3196	0	
7YD3		Single-chain variable fragment of app 3D1 antibody	2022-07-03	2023-07-05	Yan, L.,Yang, G.	Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1	To Be Published	0	0	0	0	
8H0N	37369656	Crystal structure of the human METTL1-WDR4 complex	2022-09-30	2023-07-05	Jin, X.,Guan, Z.,Hu, N.,He, C.,Yin, P.,Gong, Z.,Zhang, D.	Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1.	Cell Discov	2023	9	65	65	
8J0K	37409559	Crystal structure of human TFAP2A in complex with DNA	2023-04-11	2023-07-05	Liu, K.,Xiao, Y.,Gan, L.,Li, W.,Zhang, J.,Min, J.	Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.	Nucleic Acids Res.	2023	51	8270	8282	
7Y74		Apostichopus japonicus ferritin mutant-D129A/E132A	2022-06-21	2023-07-12	Wu, Y.	Apostichopus japonicus ferritin mutant-D129A/E132A	To Be Published	0	0	0	0	
7Y77	37349549	Crystal structure of rice NAL1	2022-06-21	2023-07-12	Li, W.,Yan, J.,Zhang, Y.,Zhang, F.,Guan, Z.,Yao, Y.,Chang, Y.,Tu, H.,Li, X.,Wang, H.,Xiong, H.,Lai, X.,Yin, P.,Xiong, L.	Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice.	Nat.Plants	2023	9	1130	1142	
7Y8J		3D1 in complex with 6-mer HR1 peptide from SARS-CoV-2	2022-06-24	2023-07-12	Lei, Y.	Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1	To Be Published	0	0	0	0	
8IVW	37134152	Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment	2023-03-29	2023-07-12	Xu, Z.,Goel, H.L.,Burkart, C.,Burman, L.,Chong, Y.E.,Barber, A.G.,Geng, Y.,Zhai, L.,Wang, M.,Kumar, A.,Menefee, A.,Polizzi, C.,Eide, L.,Rauch, K.,Rahman, J.,Hamel, K.,Fogassy, Z.,Klopp-Savino, S.,Paz, S.,Zhang, M.,Cubitt, A.,Nangle, L.A.,Mercurio, A.M.	Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.	Sci Transl Med	2023	15	0	0	
8IVX	37134152	Crystal structure of NRP2 in complex with aNRP2-14 Fab fragment	2023-03-29	2023-07-12	Xu, Z.,Goel, H.L.,Burkart, C.,Burman, L.,Chong, Y.E.,Barber, A.G.,Geng, Y.,Zhai, L.,Wang, M.,Kumar, A.,Menefee, A.,Polizzi, C.,Eide, L.,Rauch, K.,Rahman, J.,Hamel, K.,Fogassy, Z.,Klopp-Savino, S.,Paz, S.,Zhang, M.,Cubitt, A.,Nangle, L.A.,Mercurio, A.M.	Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.	Sci Transl Med	2023	15	0	0	
7WLH		The crystal structure of African swine fever virus I215L	2022-01-13	2023-07-19	Shen, Z.,Liang, R.,Yang, Y.,Peng, G.	The crystal structure of African swine fever virus I215L	To Be Published	0	0	0	0	
7YIW	37422472	The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH	2022-07-18	2023-07-19	Yu, Y.,Rong, K.,Yao, D.,Zhang, Q.,Cao, X.,Rao, B.,Xia, Y.,Lu, Y.,Shen, Y.,Yao, Y.,Xu, H.,Ma, P.,Cao, Y.,Qin, A.	The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.	Nat Commun	2023	14	4048	4048	
8I7X	37352796	Crystal structure of human ClpP in complex with ZG36	2023-02-02	2023-07-19	Zhang, R.,Wang, P.,Wei, B.,Chen, L.,Song, X.,Pan, Y.,Li, J.,Gan, J.,Zhang, T.,Yang, C.G.	Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists.	Eur.J.Med.Chem.	2023	258	115577	115577	
7YKC	37454208	crystal structure of the Phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (ARO3) from Saccharomyces cerevisiae	2022-07-22	2023-07-26	Liu, H.,Xiao, Q.,Wu, X.,Ma, H.,Li, J.,Guo, X.,Liu, Z.,Zhang, Y.,Luo, Y.	Mechanistic investigation of a D to N mutation in DAHP synthase that dictates carbon flux into the shikimate pathway in yeast.	Commun Chem	2023	6	152	152	
7YKO		Crystal structure of a novel alpha/beta hydrolase mutant from thermomonospora curvata in complex with pentane-1,5-diol	2022-07-23	2023-07-26	Han, X.,Jian, G.,Bornscheuer, U.T.,Wei, R.,Liu, W.	Crystal structure of a novel alpha/beta hydrolase mutant from thermomonospora curvata in complex with pentane-1,5-diol	To Be Published	0	0	0	0	
7YL2		Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004	2022-07-25	2023-07-26	Huang, Y.,Wei, A.,Dong, R.,Xu, H.,Zhang, C.,Chen, Z.,Li, J.,Wu, X.,Zhang, Y.,Xu, Y.	Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004	To Be Published	0	0	0	0	
7YW2	37334830	Crystal structure of tRNA 2'-phosphotransferase from Mus musculus	2022-08-21	2023-07-26	Yang, X.,Wang, J.,Li, S.,Li, X.,Gong, J.,Yan, Z.,Zhou, H.,Wu, C.,Liu, X.	Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.	Nucleic Acids Res.	2023	51	7649	7665	
7YW3	37334830	Crystal structure of tRNA 2'-phosphotransferase from Homo sapiens	2022-08-21	2023-07-26	Yang, X.,Wang, J.,Li, S.,Li, X.,Gong, J.,Yan, Z.,Zhou, H.,Wu, C.,Liu, X.	Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.	Nucleic Acids Res.	2023	51	7649	7665	
7YW4	37334830	Crystal structure of tRNA 2'-phosphotransferase from Saccharomyces cerevisiae	2022-08-21	2023-07-26	Yang, X.,Wang, J.,Li, S.,Li, X.,Gong, J.,Yan, Z.,Zhou, H.,Wu, C.,Liu, X.	Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.	Nucleic Acids Res.	2023	51	7649	7665	
8GUG	37164131	Structure of VPA0770 toxin bound to VPA0769 antitoxin in Vibrio parahaemolyticus	2022-09-12	2023-07-26	Zhang, Y.,Song, X.,Chen, C.,Liu, L.,Xu, Y.,Zhang, N.,Huang, W.,Zheng, J.,Yuan, W.,Tang, L.,Lin, Z.	Structural insights of the toxin-antitoxin system VPA0770-VPA0769 in Vibrio parahaemolyticus.	Int.J.Biol.Macromol.	2023	242	124755	124755	
7YKF	37163606	Crystal structure of MAGI2 PDZ0-GK/pEphexin4 complex	2022-07-22	2023-08-02	Zhang, M.,Cao, A.,Lin, L.,Chen, Y.,Shang, Y.,Wang, C.,Zhang, M.,Zhu, J.	Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.	Sci Adv	2023	9	0	0	
7YKG	37163606	Crystal structure of MAGI2 PDZ0-GK/pSGEF complex	2022-07-22	2023-08-02	Zhang, M.,Cao, A.,Lin, L.,Chen, Y.,Shang, Y.,Wang, C.,Zhang, M.,Zhu, J.	Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs.	Sci Adv	2023	9	0	0	
8GOL	37468532	crystal structure of SulE	2022-08-25	2023-08-02	Liu, B.,Wang, W.,Qiu, J.,Huang, X.,Qiu, S.,Bao, Y.,Xu, S.,Ruan, L.,Ran, T.,He, J.	Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity.	Nat Commun	2023	14	4343	4343	
8GP0	37468532	crystal structure of SulE	2022-08-25	2023-08-02	Liu, B.,Wang, W.,Qiu, J.,Huang, X.,Qiu, S.,Bao, Y.,Xu, S.,Ruan, L.,Ran, T.,He, J.	Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity.	Nat Commun	2023	14	4343	4343	
8H8Y		Crystal structure of AbHheG from Acidimicrobiia bacterium	2022-10-24	2023-08-02	Zhou, C.,Chen, X.,Lv, T.,Han, X.,Feng, J.,Liu, W.,Wu, Q.,Zhu, D.	Flipping the Substrate Creates a Highly Selective Halohydrin Dehalogenase for the Synthesis of Chiral 4-Aryl-2-oxazolidinones from Readily Available Epoxides	Acs Catalysis	2023	13	4768	4777	
8J7G	37468532	crystal structure of SulE mutant	2023-04-27	2023-08-02	Liu, B.,Wang, W.,Qiu, J.,Huang, X.,Qiu, S.,Bao, Y.,Xu, S.,Ruan, L.,Ran, T.,He, J.	Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity.	Nat Commun	2023	14	4343	4343	
8J7J	37468532	crystal structure of SulE mutant	2023-04-27	2023-08-02	Liu, B.,Wang, W.,Qiu, J.,Huang, X.,Qiu, S.,Bao, Y.,Xu, S.,Ruan, L.,Ran, T.,He, J.	Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity.	Nat Commun	2023	14	4343	4343	
8J7K	37468532	crystal structure of SulE mutant	2023-04-27	2023-08-02	Liu, B.,Wang, W.,Qiu, J.,Huang, X.,Qiu, S.,Bao, Y.,Xu, S.,Ruan, L.,Ran, T.,He, J.	Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity.	Nat Commun	2023	14	4343	4343	
8JT3		Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in complex with amino donor L-Arg	2023-06-21	2023-08-02	Chen, R.,Su, K.,Zhang, Y.,Zhu, Y.,Liu, J.,Xu, J.	Co-crystal structure provides insights on transaminase CrmG recognition amino donor L-Arg	Biochem.Biophys.Res.Commun.	2023	675	41	45	
7YAW	37220641	Crystal structure of ZAK in complex with compound YH-180	2022-06-28	2023-08-09	Zhou, Y.,Yu, H.,Vind, A.C.,Kong, L.,Liu, Y.,Song, X.,Tu, Z.,Yun, C.,Smaill, J.B.,Zhang, Q.W.,Ding, K.,Bekker-Jensen, S.,Lu, X.	Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov).	J.Med.Chem.	2023	66	7405	7420	
7YAZ	37220641	Crystal structure of ZAK in complex with compound YH-186	2022-06-28	2023-08-09	Zhou, Y.,Yu, H.,Vind, A.C.,Kong, L.,Liu, Y.,Song, X.,Tu, Z.,Yun, C.,Smaill, J.B.,Zhang, Q.W.,Ding, K.,Bekker-Jensen, S.,Lu, X.	Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov).	J.Med.Chem.	2023	66	7405	7420	
7YLQ		Crystal structure of Microcystinase C from Sphingomonas sp. ACM-3962 at 2.6 A resolution	2022-07-26	2023-08-09	Guo, X.,Li, Z.,Ding, W.,Yin, P.,Feng, L.	Crystal structure of Microcystin C from Sphingomonas sp. ACM-3962 at 2.6 A resolution	To Be Published	0	0	0	0	
8GPK	37542068	Crystal structure of human anti-HIV-1 broadly neutralizing antibody F6 Fab	2022-08-26	2023-08-09	Niu, J.,Wang, Q.,Zhao, W.,Meng, B.,Xu, Y.,Zhang, X.,Feng, Y.,Qi, Q.,Hao, Y.,Zhang, X.,Liu, Y.,Xiang, J.,Shao, Y.,Yang, B.	Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs.	Nat Commun	2023	14	4676	4676	
7Y5K	37616371	Crystal structure of human CAF-1 core complex in spacegroup C2221	2022-06-17	2023-08-16	Liu, C.P.,Yu, Z.,Xiong, J.,Hu, J.,Song, A.,Ding, D.,Yu, C.,Yang, N.,Wang, M.,Yu, J.,Hou, P.,Zeng, K.,Li, Z.,Zhang, Z.,Zhang, X.,Li, W.,Zhang, Z.,Zhu, B.,Li, G.,Xu, R.M.	Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.	Science	2023	381	0	0	
7YQE	38346942	Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54.	2022-08-06	2023-08-16	Li, Z.,Yang, X.,Fu, R.,Wu, Z.,Xu, S.,Jiao, J.,Qian, M.,Zhang, L.,Wu, C.,Xie, T.,Yao, J.,Wu, Z.,Li, W.,Ma, G.,You, Y.,Chen, Y.,Zhang, H.K.,Cheng, Y.,Tang, X.,Wu, P.,Lian, G.,Wei, H.,Zhao, J.,Xu, J.,Ai, L.,Siwko, S.,Wang, Y.,Ding, J.,Song, G.,Luo, J.,Liu, M.,Xiao, J.	Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.	Nat Commun	2024	15	1300	1300	
7YSF	38086788	Crystal structure of ZNF524 ZF1-4 in complex with telomeric DNA	2022-08-12	2023-08-16	Braun, H.,Xu, Z.,Chang, F.,Viceconte, N.,Rane, G.,Levin, M.,Lototska, L.,Roth, F.,Hillairet, A.,Fradera-Sola, A.,Khanchandani, V.,Sin, Z.W.,Yong, W.K.,Dreesen, O.,Yang, Y.,Shi, Y.,Li, F.,Butter, F.,Kappei, D.	ZNF524 directly interacts with telomeric DNA and supports telomere integrity.	Nat Commun	2023	14	8252	8252	
8H09	37558668	Structure of the thermolabile hemolysin from Vibrio alginolyticus (apo form)	2022-09-28	2023-08-16	Wang, C.,Liu, C.,Zhu, X.,Peng, Q.,Ma, Q.	Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase.	Nat Commun	2023	14	4795	4795	
8H0B	37558668	Structure of the thermolabile hemolysin from Vibrio alginolyticus (in complex with oleic acid)	2022-09-28	2023-08-16	Wang, C.,Liu, C.,Zhu, X.,Peng, Q.,Ma, Q.	Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase.	Nat Commun	2023	14	4795	4795	
8H0C	37558668	Structure of the thermolabile hemolysin from Vibrio alginolyticus (in complex with arachidonic acid)	2022-09-28	2023-08-16	Wang, C.,Liu, C.,Zhu, X.,Peng, Q.,Ma, Q.	Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase.	Nat Commun	2023	14	4795	4795	
8H0D	37558668	Structure of the thermolabile hemolysin from Vibrio alginolyticus (in complex with docosahexaenoic acid)	2022-09-28	2023-08-16	Wang, C.,Liu, C.,Zhu, X.,Peng, Q.,Ma, Q.	Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase.	Nat Commun	2023	14	4795	4795	
8H41		Crystal structure of a decarboxylase from Trichosporon moniliiforme in complex with o-nitrophenol	2022-10-09	2023-08-16	Chen, F.,Zhao, Y.,Zhang, C.,Wang, W.,Gao, J.,Li, Q.,Qin, H.,Dai, Y.,Liu, W.,Liu, F.,Su, H.,Sheng, X.	A Combined Computational-Experimental Study on the Substrate Binding and Reaction Mechanism of Salicylic Acid Decarboxylase	Catalysts	2022	12	0	0	
8HGT	36790023	Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei	2022-11-15	2023-08-16	Zhao, P.,Kong, F.,Jiang, Y.,Qin, X.,Tian, X.,Cong, Z.	Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels.	J.Am.Chem.Soc.	2023	145	5506	5511	
8HR2	37419228	Ternary Crystal Complex Structure of RBD with NB1B5 and NB1C6	2022-12-14	2023-08-16	Sun, Z.,Wang, L.,Li, L.,Sun, Y.,Zhang, D.,Zhou, S.,Li, Y.,Li, X.,Qiao, H.,Cui, Q.,Lan, Z.,Meng, X.,Xu, J.,Geng, Y.,Dai, Y.	Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes.	J.Struct.Biol.	2023	215	107996	107996	
8JOP	37437852	Crystal structure of the SARS-CoV-2 main protease in complex with 11a	2023-06-08	2023-08-16	Wang, F.,Zeng, R.,Qiao, J.,Xia, A.,Li, Y.,Li, F.,Wu, Y.,Liu, Y.,Zhao, X.,Lei, J.,Yang, S.	Discovery of benzodiazepine derivatives as a new class of covalent inhibitors of SARS-CoV-2 main protease.	Bioorg.Med.Chem.Lett.	2023	92	129407	129407	
7YTO	36926920	The Crystal Structure Analysis of Creatine Amidinohydrolase from Alcaligenes sp. KS-85	2022-08-15	2023-08-23	Jiang, F.,Bian, J.,Liu, H.,Li, S.,Bai, X.,Zheng, L.,Jin, S.,Liu, Z.,Yang, G.Y.,Hong, L.	Creatinase: Using Increased Entropy to Improve the Activity and Thermostability.	J.Phys.Chem.B	2023	127	2671	2682	
8HY7		EGFR kinase domain mutant ""TMLR"" with compound 28f	2023-01-06	2023-08-23	Wang, Y.X.,Wu, C.Y.	The crystal structure of EGFR kinase domain(T790M/L858R) in complex with compound 28f	To Be Published	0	0	0	0	
8I5C		Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)	2023-01-24	2023-08-23	Lu, D.,Chen, Y.,Jiang, M.,Tan, S.G.,Chai, Y.,Gao, G.F.	Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)	Nat Commun	2023	0	0	0	
8I5D		Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)	2023-01-25	2023-08-23	Lu, D.,Chen, Y.,Jiang, M.,Tan, S.G.,Chai, Y.,Gao, G.F.	Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)	Nat Commun	2023	0	0	0	
8I5E		Crystal structure of HLA-A*11:01 in complex with KRAS peptide (VVGAGGVGK)	2023-01-25	2023-08-23	Lu, D.,Chen, Y.,Jiang, M.,Tan, S.G.,Chai, Y.,Gao, G.F.	Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)	Nat Commun	2023	0	0	0	
8IVY	37558019	Beta-Glucosidase BglA mutant E166Q in complex with glucose	2023-03-29	2023-08-23	Xiao, Y.,Dong, S.,Liu, Y.J.,You, C.,Feng, Y.,Cui, Q.	Key roles of beta-glucosidase BglA for the catabolism of both laminaribiose and cellobiose in the lignocellulolytic bacterium Clostridium thermocellum.	Int.J.Biol.Macromol.	2023	250	126226	126226	
8K5L		Structure of tRNA (cmo5U34)-methyltransferase from Fusobacterium nucleatum	2023-07-22	2023-08-23	He, S.R.,Bai, X.	Crystal Structure of CmoA from Fusobacterium nucleatum	To Be Published	0	0	0	0	
8K76		Crystal structure of S-adenosylmethionine-dependent methyltransferase from Fusobacterium nucleatum	2023-07-26	2023-08-23	He, S.R.,Bai, X.	Crystal structure of S-adenosylmethionine-dependent methyltransferase from Fusobacterium nucleatum	To Be Published	0	0	0	0	
7YI6		bnAb 3D1 in complex with 6-mer HR1 peptide from HCoV-229E S protein	2022-07-15	2023-08-30	Yan, L.,Yang, G.	Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1	To Be Published	0	0	0	0	
7YVA		Crystal structure of Candida albicans Fructose-1,6-bisphosphate aldolase complexed with lipoic acid	2022-08-19	2023-08-30	Cao, H.,Huang, Y.,Ren, Y.,Wan, J.	Crystal structure of  Candida albicans Fructose-1,6-bisphosphate aldolase complexed with lipoic acid	To Be Published	0	0	0	0	
8GMZ		Structure of methyltransferase	2022-08-22	2023-08-30	Zhang, H.,Li, X.Z.,Wen, Y.N.	Structure of methyltransferase	To Be Published	0	0	0	0	
8GN3	36657642	The crystal structure of ZBTB10 ZF1-2 in complex with telomeric vairant repeat TTGGGG	2022-08-22	2023-08-30	Wang, S.,Xu, Z.,Li, M.,Lv, M.,Shen, S.,Shi, Y.,Li, F.	Structural insights into the recognition of telomeric variant repeat TTGGGG by broad-complex, tramtrack and bric-a-brac - zinc finger protein ZBTB10.	J.Biol.Chem.	2023	299	102918	102918	
8GN4	36657642	The crystal structure of ZBTB10 ZF1-2 R767Q in complex with telomeric DNA TTAGGG	2022-08-22	2023-08-30	Wang, S.,Xu, Z.,Li, M.,Lv, M.,Shen, S.,Shi, Y.,Li, F.	Structural insights into the recognition of telomeric variant repeat TTGGGG by broad-complex, tramtrack and bric-a-brac - zinc finger protein ZBTB10.	J.Biol.Chem.	2023	299	102918	102918	
8GO6	37687215	Fungal immunomodulatory protein FIP-nha N39A	2022-08-24	2023-08-30	Liu, Y.,Hoppenbrouwers, T.,Wang, Y.,Xie, Y.,Wei, X.,Zhang, H.,Du, G.,Imam, K.M.S.U.,Wichers, H.,Li, Z.,Bastiaan-Net, S.	Glycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha ( Nectria haematococca ).	Molecules	2023	28	0	0	
8GO7	37687215	Fungal immunomodulatory protein FIP-nha N5+39A	2022-08-24	2023-08-30	Liu, Y.,Hoppenbrouwers, T.,Wang, Y.,Xie, Y.,Wei, X.,Zhang, H.,Du, G.,Imam, K.M.S.U.,Wichers, H.,Li, Z.,Bastiaan-Net, S.	Glycosylation Contributes to Thermostability and Proteolytic Resistance of rFIP-nha ( Nectria haematococca ).	Molecules	2023	28	0	0	
8GQT		Structure of Mpro complexed with Quercetin	2022-08-30	2023-08-30	Dong, J.,Yang, G.-F.	Structure of Mpro complexed with Quercetin	To Be Published	0	0	0	0	
8JJ6		Structure of the NELF-BCE complex	2023-05-29	2023-08-30	Wang, Z.,Cao, Y.,Qin, Y.	The crystal structure of the human NELF-B, NELF-C, and NELF-E trimeric complex	To Be Published	0	0	0	0	
8K1I		Crystal structure of arabinose dehydrogenase from Candida auris	2023-07-11	2023-08-30	Zhang, J.,Bai, X.,He, S.R.,Zhao, Z.D.	Crystal structure of arabinose dehydrogenase from Candida auris	To Be Published	0	0	0	0	
8SKN	37583827	Crystal structure of compound 3-bound human Dynamin-1-like protein GTPase-BSE fusion	2023-04-20	2023-08-30	Furuya, T.,Lin, J.,Afanaseva, A.,Molz, L.,Lagu, B.,Ma, B.	Discovery of Potent Allosteric DRP1 Inhibitors by Disrupting Protein-Protein Interaction with MiD49.	Acs Med.Chem.Lett.	2023	14	1095	1099	
7X3P		Crystal structure of human SIRT5 in complex with diazirine inhibitor 9	2022-03-01	2023-09-06	Li, G.-B.,Deng, J.	Crystal structure of human SIRT5 in complex with diazirine inhibitor 9	To Be Published	0	0	0	0	
7YLB		Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis	2022-07-26	2023-09-06	Hu, M.,Du, Y.,Sun, R.,Hao, Q.	Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis	To Be Published	0	0	0	0	
7YVV		AcmP1, R-4-hydroxymandelate synthase	2022-08-19	2023-09-06	Zhang, B.,Ge, H.M.	Characterization of AcmP1 as the native R-4-hydroxymandelate synthase from biosynthetic pathway of Amycolamycins	To Be Published	0	0	0	0	
8I5Z	37729918	LDH Mutant P101Q-(An unexpected single-point mutation triggers the unleashing of catalytic potential of a NADH-dependent dehydrogenase)	2023-01-26	2023-09-06	Liu, J.,Liu, G.,Han, X.,Tao, F.,Xu, P.	Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase.	Structure	2023	31	1616	0	
8IQ0	37421623	Crystal structure of hydrogen sulfide-bound superoxide dismutase in oxidized state	2023-03-15	2023-09-06	Wu, D.D.,Jin, S.,Cheng, R.X.,Cai, W.J.,Xue, W.L.,Zhang, Q.Q.,Yang, L.J.,Zhu, Q.,Li, M.Y.,Lin, G.,Wang, Y.Z.,Mu, X.P.,Wang, Y.,Zhang, I.Y.,Zhang, Q.,Chen, Y.,Cai, S.Y.,Tan, B.,Li, Y.,Chen, Y.Q.,Zhang, P.J.,Sun, C.,Yin, Y.,Wang, M.J.,Zhu, Y.Z.,Tao, B.B.,Zhou, J.H.,Huang, W.X.,Zhu, Y.C.	Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.	Cell Rep	2023	42	112750	112750	
8IQ1	37421623	Crystal structure of hydrogen sulfide-bound superoxide dismutase in reduced state	2023-03-15	2023-09-06	Wu, D.D.,Jin, S.,Cheng, R.X.,Cai, W.J.,Xue, W.L.,Zhang, Q.Q.,Yang, L.J.,Zhu, Q.,Li, M.Y.,Lin, G.,Wang, Y.Z.,Mu, X.P.,Wang, Y.,Zhang, I.Y.,Zhang, Q.,Chen, Y.,Cai, S.Y.,Tan, B.,Li, Y.,Chen, Y.Q.,Zhang, P.J.,Sun, C.,Yin, Y.,Wang, M.J.,Zhu, Y.Z.,Tao, B.B.,Zhou, J.H.,Huang, W.X.,Zhu, Y.C.	Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.	Cell Rep	2023	42	112750	112750	
8J7E	37580554	Crystal structure of BRIL in complex with 1b3 Fab	2023-04-27	2023-09-06	Guo, Q.,He, B.,Zhong, Y.,Jiao, H.,Ren, Y.,Wang, Q.,Ge, Q.,Gao, Y.,Liu, X.,Du, Y.,Hu, H.,Tao, Y.	A method for structure determination of GPCRs in various states.	Nat.Chem.Biol.	2024	20	74	82	
8GTV		SARS-CoV-2 3CL protease (3CLpro) in complex with compound JZD-07	2022-09-08	2023-09-13	Xu, Y.C.,Zang, Y.,Zhou, Y.	Development of novel inhibitors against SARS-CoV-2 3CLpro	To Be Published	0	0	0	0	
8GTW		SARS-CoV-2 3CL protease (3CLpro) in complex with compound JZD-26	2022-09-08	2023-09-13	Xu, Y.C.,Zang, Y.,Zhou, Y.	Development of novel inhibitors against SARS-CoV-2 3CLpro	To Be Published	0	0	0	0	
8GTY		Crystal structure of exopolyphosphatase (PPX) from Zymomonas mobilis in complex with magnesium ions	2022-09-09	2023-09-13	Lu, Z.,Hu, Y.,Wang, J.,Zhang, B.,Zhang, Y.,Cui, Z.,Zhang, L.,Zhang, A.	Structure of the exopolyphosphatase (PPX) from Zymomonas mobilis reveals a two-magnesium-ions PPX	Int.J.Biol.Macromol.	2024	262	129796	0	
8H18	37663930	Crystal structure of DnaQ domain of Streptococcus thermophilus strain DGCC 7710	2022-10-01	2023-09-13	Tang, D.,Jia, T.,Luo, Y.,Mou, B.,Cheng, J.,Qi, S.,Yao, S.,Su, Z.,Yu, Y.,Chen, Q.	DnaQ mediates directional spacer acquisition in the CRISPR-Cas system by a time-dependent mechanism.	Innovation (N Y)	2023	4	100495	100495	
8H2F	37663930	Crystal structure of DnaQ domain in complex witn TMP of Streptococcus thermophilus strain DGCC 7710	2022-10-05	2023-09-13	Tang, D.,Jia, T.,Luo, Y.,Mou, B.,Cheng, J.,Qi, S.,Yao, S.,Su, Z.,Yu, Y.,Chen, Q.	DnaQ mediates directional spacer acquisition in the CRISPR-Cas system by a time-dependent mechanism.	Innovation (N Y)	2023	4	100495	100495	
8H3T	37666836	The crystal structure of AlpH	2022-10-09	2023-09-13	Zhao, Y.,Liu, X.,Xiao, Z.,Zhou, J.,Song, X.,Wang, X.,Hu, L.,Wang, Y.,Sun, P.,Wang, W.,He, X.,Lin, S.,Deng, Z.,Pan, L.,Jiang, M.	O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis.	Nat Commun	2023	14	5372	5372	
8JYE	37674084	Crystal Structure of Intracellular B30.2 Domain of BTN3A1 and BTN2A1 in Complex with HMBPP	2023-07-03	2023-09-13	Yuan, L.,Ma, X.,Yang, Y.,Qu, Y.,Li, X.,Zhu, X.,Ma, W.,Duan, J.,Xue, J.,Yang, H.,Huang, J.W.,Yi, S.,Zhang, M.,Cai, N.,Zhang, L.,Ding, Q.,Lai, K.,Liu, C.,Zhang, L.,Liu, X.,Yao, Y.,Zhou, S.,Li, X.,Shen, P.,Chang, Q.,Malwal, S.R.,He, Y.,Li, W.,Chen, C.,Chen, C.C.,Oldfield, E.,Guo, R.T.,Zhang, Y.	Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate V gamma 9V delta 2 T cells.	Nature	2023	621	840	848	
8JZV		RPA70N-ETAA1 fusion	2023-07-06	2023-09-13	Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C.	Structural characterization of human RPA70N association with DNA damage response proteins.	Elife	2023	12	0	0	
8JZY		RPA70N-RAD9 fusion	2023-07-06	2023-09-13	Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C.	Structural characterization of human RPA70N association with DNA damage response proteins.	Elife	2023	12	0	0	
8K00		RPA70N-MRE11 fusion	2023-07-07	2023-09-13	Wu, Y.Y.,Zang, N.,Fu, W.M.,Zhou, C.	Structural characterization of human RPA70N association with DNA damage response proteins.	Elife	2023	12	0	0	
7XAE		Crystal strucutre of PD-L1 and 3ONJA protein	2022-03-17	2023-09-20	Liu, K.F.,Xu, Z.P.,Han, P.,Gao, G.F.,Chai, Y.,Tan, S.G.	Crystal strucutre of PD-L1 and 2IC6 protein	To Be Published	0	0	0	0	
8GVL	38416831	PTPN21 FERM	2022-09-15	2023-09-20	Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H.	Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.	Sci Adv	2024	10	0	0	
8GVV	38416831	PTPN21 PTP domain C1108S mutant	2022-09-15	2023-09-20	Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H.	Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.	Sci Adv	2024	10	0	0	
8GW3		Crystal structure of human TAK1 kinase domain fused with TAB1	2022-09-16	2023-09-20	Liu, J.,Sun, W.,Gao, J.	Crystal structure of human TAK1 kinase domain fused with TAB1	To Be Published	0	0	0	0	
8GWD		Crystal structure of AtHPPD-Y18734 complex	2022-09-16	2023-09-20	Yang, G.-F.,Lin, H.-Y.,Dong, J.	Crystal structure of AtHPPD-Y18734 complex	To Be Published	0	0	0	0	
8GWH	38416831	PTPN21 PTP domain C1108S mutant in complex with SRC pTyr530 peptide	2022-09-17	2023-09-20	Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H.	Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.	Sci Adv	2024	10	0	0	
8GX3		The crystal structure of human Calpain-1 protease core in complex with 14c	2022-09-18	2023-09-20	Zhao, Y.,Zhao, J.,Shao, M.,Yang, H.,Rao, Z.	The crystal structure of human Calpain-1 protease core  in complex with 14c	To Be Published	0	0	0	0	
8HZZ	37863881	GuApiGT (UGT79B74)	2023-01-10	2023-09-20	Wang, H.T.,Wang, Z.L.,Chen, K.,Yao, M.J.,Zhang, M.,Wang, R.S.,Zhang, J.H.,Agren, H.,Li, F.D.,Li, J.,Qiao, X.,Ye, M.	Insights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants.	Nat Commun	2023	14	6658	6658	
8IA3	37690682	Crystal structure of human USF2 bHLHLZ domain in complex with DNA	2023-02-07	2023-09-20	Huang, C.,Xia, M.,Qiao, H.,Liu, Z.,Lin, Y.,Sun, H.,Yu, B.,Fang, P.,Wang, J.	Tetramerization of upstream stimulating factor USF2 requires the elongated bent leucine zipper of the bHLH-LZ domain.	J.Biol.Chem.	2023	299	105240	105240	
8J25	37655965	Crystal structure of PML B-box2 mutant	2023-04-14	2023-09-20	Bercier, P.,Wang, Q.Q.,Zang, N.,Zhang, J.,Yang, C.,Maimaitiyiming, Y.,Abou-Ghali, M.,Berthier, C.,Wu, C.,Niwa-Kawakita, M.,Dirami, T.,Geoffroy, M.C.,Ferhi, O.,Quentin, S.,Benhenda, S.,Ogra, Y.,Gueroui, Z.,Zhou, C.,Naranmandura, H.,de The, H.,Lallemand-Breitenbach, V.	Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function.	Cancer Discov	2023	13	2548	2565	
8J3O	37455264	Formate dehydrogenase wild-type enzyme from Candida dubliniensis complexed with NADH	2023-04-17	2023-09-20	Ma, W.,Geng, Q.,Chen, C.,Zheng, Y.C.,Yu, H.L.,Xu, J.H.	Engineering a Formate Dehydrogenase for NADPH Regeneration.	Chembiochem	2023	24	0	0	
8J3P	37455264	Formate dehydrogenase mutant from from Candida dubliniensis M4 complexed with NADP+	2023-04-17	2023-09-20	Ma, W.,Geng, Q.,Chen, C.,Zheng, Y.C.,Yu, H.L.,Xu, J.H.	Engineering a Formate Dehydrogenase for NADPH Regeneration.	Chembiochem	2023	24	0	0	
8J69	37794593	Crystal structure of HORMA domain-containing protein 1 (HORMAD1) from Homo sapiens	2023-04-25	2023-09-20	Wang, H.,Xie, R.,Niu, F.,Yang, Q.,An, L.,Wu, C.,Liu, X.,Yang, X.	Structural and biochemical insights into the interaction mechanism underlying HORMAD1 and its partner proteins.	Structure	2023	31	1578	0	
8JIY	37951443	A carbohydrate binding domain of a putative chondroitinase	2023-05-29	2023-09-20	Liu, G.,Chang, Y.,Mei, X.,Chen, G.,Zhang, Y.,Jiang, X.,Tao, W.,Xue, C.	Identification and structural characterization of a novel chondroitin sulfate-specific carbohydrate-binding module: The first member of a new family, CBM100.	Int.J.Biol.Macromol.	2024	255	127959	127959	
7XB8		Phosphoglycerate mutase 1 complexed with a covalent inhibitor	2022-03-21	2023-09-27	Jiang, L.L.,Zhou, L.	Phosphoglycerate mutase 1 complexed with a covalent inhibitor	To Be Published	0	0	0	0	
7XB9		Phosphoglycerate mutase 1 complexed with a covalent inhibitor	2022-03-21	2023-09-27	Jiang, L.L.,Zhou, L.	Phosphoglycerate mutase 1 complexed with a covalent inhibitor	To Be Published	0	0	0	0	
7XBA		Glutathione S-transferase bound with a covalent inhibitor	2022-03-21	2023-09-27	Jiang, L.L.,Zhou, L.	Glutathione S-transferase bound with a covalent inhibitor	To Be Published	0	0	0	0	
7Y99	38368459	Crystal Structure Analysis of cp2 bound BCLxl	2022-06-24	2023-09-27	Li, F.,Liu, J.,Liu, C.,Liu, Z.,Peng, X.,Huang, Y.,Chen, X.,Sun, X.,Wang, S.,Chen, W.,Xiong, D.,Diao, X.,Wang, S.,Zhuang, J.,Wu, C.,Wu, D.	Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.	Nat Commun	2024	15	1476	1476	
8GXE	38416831	PTPN21 FERM PTP complex	2022-09-19	2023-09-27	Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H.	Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.	Sci Adv	2024	10	0	0	
8GXG		The crystal structure of SARS-CoV-2 main protease in complex with 14a	2022-09-20	2023-09-27	Zhao, Y.,Zhao, J.,Shao, M.,Yang, H.,Rao, Z.	The crystal structure of SARS-CoV-2 main protease in complex with 14a	To Be Published	0	0	0	0	
8GXH		The crystal structure of SARS-CoV-2 main protease in complex with 14b	2022-09-20	2023-09-27	Zhao, Y.,Zhao, J.,Shao, M.,Yang, H.,Rao, Z.	The crystal structure of SARS-CoV-2 main protease  in complex with 14b	To Be Published	0	0	0	0	
8GXI		The crystal structure of SARS-CoV-2 main protease in complex with 14c	2022-09-20	2023-09-27	Zhao, Y.,Zhao, J.,Shao, M.,Yang, H.,Rao, Z.	The crystal structure of SARS-CoV-2 main protease  in complex with 14c	To Be Published	0	0	0	0	
8HLW	37720100	Crystal structure of SIRT3 in complex with H4K16la peptide	2022-12-01	2023-09-27	Fan, Z.,Liu, Z.,Zhang, N.,Wei, W.,Cheng, K.,Sun, H.,Hao, Q.	Identification of SIRT3 as an eraser of H4K16la.	Iscience	2023	26	107757	107757	
8HLY	37720100	Crystal structure of SIRT3 in complex with H3K23la peptide	2022-12-01	2023-09-27	Fan, Z.,Liu, Z.,Zhang, N.,Wei, W.,Cheng, K.,Sun, H.,Hao, Q.	Identification of SIRT3 as an eraser of H4K16la.	Iscience	2023	26	107757	107757	
8I0A	37178306	Structure of alpha-L-Arabinofuranosidase from Trametes hirsuta	2023-01-10	2023-09-27	Si, Z.,Cai, Y.,Zhao, L.,Han, L.,Wang, F.,Yang, X.,Gao, X.,Lu, M.,Liu, W.	Structure and function characterization of the alpha-L-arabinofuranosidase from the white-rot fungus Trametes hirsuta.	Appl.Microbiol.Biotechnol.	2023	107	3967	3981	
8JAC	37603751	Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-16	2023-05-05	2023-09-27	Liang, J.,Liu, F.,Xu, P.,Shangguan, W.,Hu, T.,Wang, S.,Yang, X.,Xiong, Z.,Yang, X.,Guddat, L.W.,Yu, B.,Rao, Z.,Zhang, B.	Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
8JAD	37603751	Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-17	2023-05-05	2023-09-27	Liang, J.,Liu, F.,Xu, P.,Shangguan, W.,Hu, T.,Wang, S.,Yang, X.,Xiong, Z.,Yang, X.,Guddat, L.W.,Yu, B.,Rao, Z.,Zhang, B.	Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
8H3Z	38177666	Crystal structure of the effector-binding domain of the LysR-type trasncription factor NtcB from Anabaena PCC 7120	2022-10-09	2023-10-04	Han, S.J.,Jiang, Y.L.,You, L.L.,Shen, L.Q.,Wu, X.,Yang, F.,Cui, N.,Kong, W.W.,Sun, H.,Zhou, K.,Meng, H.C.,Chen, Z.P.,Chen, Y.,Zhang, Y.,Zhou, C.Z.	DNA looping mediates cooperative transcription activation.	Nat.Struct.Mol.Biol.	2024	31	293	299	
8HID	37216701	HUMAN ERYTHROCYTE CATALSE COMPLEXED WITH BT-Br	2022-11-19	2023-10-04	Cao, Y.Y.,Chen, Y.Y.,Wang, M.S.,Tong, J.J.,Xu, M.,Zhao, C.,Lin, H.Y.,Mei, L.C.,Dong, J.,Zhang, W.L.,Qin, Y.X.,Huang, W.,Zhang, D.,Yang, G.F.	A catalase inhibitor: Targeting the NADPH-binding site for castration-resistant prostate cancer therapy.	Redox Biol	2023	63	102751	102751	
8J98		A near-infrared fluorescent protein of de novo backbone design	2023-05-02	2023-10-04	Hu, X.,Xu, Y.	De novo backbone design for monomerization of near-infrared fluorescent protein	To Be Published	0	0	0	0	
8JA9	37603751	Crystal structure of Mycobacterium tuberculosis LpqY in complex with trehalose analogue YB-03	2023-05-05	2023-10-04	Liang, J.,Liu, F.,Xu, P.,Shangguan, W.,Hu, T.,Wang, S.,Yang, X.,Xiong, Z.,Yang, X.,Guddat, L.W.,Yu, B.,Rao, Z.,Zhang, B.	Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
8KIH		PhmA, a type I diterpene synthase without NST/DTE motif	2023-08-23	2023-10-04	Zhang, L.,Zhang, B.,Zhu, A.,Liu, S.H.,Wu, R.,Zhang, X.,Xu, Z.R.,Ge, H.M.	Biosynthesis of Platelet Activating Factor Antagonist Phomactins Revealing a New Class of Type I Diterpene Synthase	To Be Published	0	0	0	0	
8H1S		Crystal structure of apo-LptDE complex	2022-10-03	2023-10-11	Luo, Q.,Wang, C.,Qiao, S.	Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis	To Be Published	0	0	0	0	
8JYT		Ancestral imine reducatase N560	2023-07-03	2023-10-11	Zhu, X.X.,Zheng, G.W.	The structure of ancestral imine reductase N560.	To Be Published	0	0	0	0	
8H43		Crystal structure of PHF1 Tudor domain in complex with hit 1	2022-10-10	2023-10-18	Liu, Y.,Ruan, K.	Crystal structure of PHF1 Tudor domain in complex with hit 1	To be published	0	0	0	0	
8H5T	38033141	Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-015	2022-10-13	2023-10-18	Yang, J.,Lin, S.,Chen, Z.,Yang, F.,Guo, L.,Wang, L.,Duan, Y.,Zhang, X.,Dai, Y.,Yin, K.,Yu, C.,Yuan, X.,Sun, H.,He, B.,Cao, Y.,Ye, H.,Dong, H.,Liu, X.,Chen, B.,Li, J.,Zhao, Q.,Lu, G.	Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.	Plos Pathog.	2023	19	0	0	
8H5U	38033141	Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-021	2022-10-13	2023-10-18	Yang, J.,Lin, S.,Chen, Z.,Yang, F.,Guo, L.,Wang, L.,Duan, Y.,Zhang, X.,Dai, Y.,Yin, K.,Yu, C.,Yuan, X.,Sun, H.,He, B.,Cao, Y.,Ye, H.,Dong, H.,Liu, X.,Chen, B.,Li, J.,Zhao, Q.,Lu, G.	Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.	Plos Pathog.	2023	19	0	0	
8H5Y	36614183	Crystal structure of RadD- ADP complex	2022-10-14	2023-10-18	Tian, L.F.,Kuang, X.,Ding, K.,Gao, H.,Tang, Q.,Yan, X.X.,Xu, W.	Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.	Int J Mol Sci	2023	24	0	0	
8H5Z	36614183	Crystal structure of RadD/ATP analogue complex	2022-10-14	2023-10-18	Tian, L.F.,Kuang, X.,Ding, K.,Gao, H.,Tang, Q.,Yan, X.X.,Xu, W.	Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.	Int J Mol Sci	2023	24	0	0	
8H6A		Crystal structure of AtHPPD complexed with YH21477	2022-10-16	2023-10-18	Yang, G.-F.	Crystal structure of AtHPPD complexed with YH20702	To Be Published	0	0	0	0	
8H6B		Crystal structure of AtHPPD complexed with YH20702	2022-10-16	2023-10-18	Yang, G.-F.	Crystal structure of AtHPPD complexed with YH20702	To Be Published	0	0	0	0	
8IFP		SARS-CoV-2 3CL protease (3CLpro) in complex with compound 1	2023-02-19	2023-10-18	Jiang, X.,Su, H.	Discovery of oral simnotrelvir, an approved SARS-CoV-2 3C-like protease inhibitor for the treatment of COVID-19	To Be Published	0	0	0	0	
8IFQ		SARS-CoV-2 3CL protease (3CLpro) in complex with compound 2	2023-02-19	2023-10-18	Jiang, X.,Su, H.	Discovery of oral simnotrelvir, an approved SARS-CoV-2 3C-like protease inhibitor for the treatment of COVID-19	To Be Published	0	0	0	0	
8IFS		SARS-CoV-2 3CL protease (3CLpro) in complex with compound 7	2023-02-19	2023-10-18	Jiang, X.,Su, H.	Discovery of oral simnotrelvir, an approved SARS-CoV-2 3C-like protease inhibitor for the treatment of COVID-19	To Be Published	0	0	0	0	
8IFT		SARS-CoV-2 3CL protease (3CLpro) in complex with compound 10	2023-02-19	2023-10-18	Jiang, X.,Su, H.	Discovery of oral simnotrelvir, an approved SARS-CoV-2 3C-like protease inhibitor for the treatment of COVID-19	To Be Published	0	0	0	0	
8IM2	37794595	Crystal structure of human HPPD complexed with NTBC	2023-03-05	2023-10-18	Dong, J.,Xiao, H.,Chen, J.N.,Zheng, B.F.,Xu, Y.L.,Chen, M.X.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.	Structure	2023	31	1604	0	
8IM3	37794595	Crystal structure of human HPPD complexed with compound a10	2023-03-05	2023-10-18	Dong, J.,Xiao, H.,Chen, J.N.,Zheng, B.F.,Xu, Y.L.,Chen, M.X.,Yang, W.C.,Lin, H.Y.,Yang, G.F.	Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.	Structure	2023	31	1604	0	
8JDG	37863926	Crystal structure of H405A mLDHD in complex with D-2-hydroxybutanoic acid	2023-05-14	2023-10-18	Jin, S.,Chen, X.,Yang, J.,Ding, J.	Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.	Nat Commun	2023	14	6638	6638	
8JDQ	37863926	Crystal structure of H405A mLDHD in complex with D-2-hydroxyisocaproic acid	2023-05-15	2023-10-18	Jin, S.,Chen, X.,Yang, J.,Ding, J.	Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.	Nat Commun	2023	14	6638	6638	
8JDT	37863926	Crystal structure of mLDHD in complex with 2-ketobutanoic acid	2023-05-15	2023-10-18	Jin, S.,Chen, X.,Yang, J.,Ding, J.	Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.	Nat Commun	2023	14	6638	6638	
8JDX	37863926	Crystal structure of mLDHD in complex with 2-ketoisovaleric acid	2023-05-15	2023-10-18	Jin, S.,Chen, X.,Yang, J.,Ding, J.	Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.	Nat Commun	2023	14	6638	6638	
8JDZ	37863926	Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid	2023-05-15	2023-10-18	Jin, S.,Chen, X.,Yang, J.,Ding, J.	Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.	Nat Commun	2023	14	6638	6638	
8HI9	37259339	SARS-CoV-2 3CL protease (3CLpro) in complex with Robinetin	2022-11-19	2023-10-25	Kruger, N.,Kronenberger, T.,Xie, H.,Rocha, C.,Pohlmann, S.,Su, H.,Xu, Y.,Laufer, S.A.,Pillaiyar, T.	Discovery of Polyphenolic Natural Products as SARS-CoV-2 M pro Inhibitors for COVID-19.	Pharmaceuticals	2023	16	0	0	
8JBA	37674362	Discovery and Crystallography Study of Novel Oxadiazole Analogs as Small Molecule PD-1/PD-L1 inhibitors	2023-05-08	2023-10-25	Liu, J.,Cheng, Y.,Yuan, L.,Liu, T.,Ruan, Y.,Ren, Y.,Li, L.,Jiang, S.,Xiao, Y.,Chen, J.	Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents.	J.Med.Chem.	2023	66	13172	13188	
7XT0		Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors	2022-05-15	2023-11-01	Wang, D.P.	Crystal structure of RNA helicase from Saint Louis encephalitis virus and discovery of its inhibitors	To Be Published	0	0	0	0	
8HX5	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(4-methoxybenzyl)thiazole-4-carboxylic acid	2023-01-04	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXE	37791640	Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-propylbenzyl)thiazole-4-carboxylic acid	2023-01-04	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXI	37791640	Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-isopropylbenzyl)thiazole-4-carboxylic acid	2023-01-04	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXN	37791640	Crystal structure of B2 Sfh-I MBL in complex with 2-amino-5-(4-(but-3-en-1-yloxy)benzyl)thiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXO	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-isobutylthiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXP	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(but-3-en-1-yl)thiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXU	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-pentylthiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXV	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-hexylthiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HXW	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-heptylthiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HY1	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(thiophen-2-ylmethyl)thiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HY2	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HY6	37791640	Crystal structure of B1 NDM-1 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid	2023-01-05	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8HYD	37791640	Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(2-(thiophen-2-yl)ethyl)thiazole-4-carboxylic acid	2023-01-06	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8J0H		Crystal structure of the fission yeast Rex1BD protein(C4H3.06)	2023-04-11	2023-11-01	Gao, J.,Sun, W.,Li, J.,Ban, H.,Zhang, T.,Liao, J.,Kim, N.,Lee, S.,Dong, Q.,Madramootoo, R.,Chen, Y.,Li, F.	Crystal structure of the fission yeast Rex1BD protein(C4H3.06)	To Be Published	0	0	0	0	
8JAO	37791640	Crystal structure of B1 IMP-1 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid	2023-05-06	2023-11-01	Yan, Y.H.,Zhang, T.T.,Li, R.,Wang, S.Y.,Wei, L.L.,Wang, X.Y.,Zhu, K.R.,Li, S.R.,Liang, G.Q.,Yang, Z.B.,Yang, L.L.,Qin, S.,Li, G.B.	Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.	J.Med.Chem.	2023	66	13746	13767	
8K8K	37751633	Structure of Klebsiella pneumonia ModA	2023-07-31	2023-11-01	Zhao, Q.,Su, X.,Wang, Y.,Liu, R.,Bartlam, M.	Structural analysis of molybdate binding protein ModA from Klebsiella pneumoniae.	Biochem.Biophys.Res.Commun.	2023	681	41	46	
8K8L	37751633	Structure of Klebsiella pneumonia ModA with molybdate	2023-07-31	2023-11-01	Zhao, Q.,Su, X.,Wang, Y.,Liu, R.,Bartlam, M.	Structural analysis of molybdate binding protein ModA from Klebsiella pneumoniae.	Biochem.Biophys.Res.Commun.	2023	681	41	46	
7EKA	34286590	crystal structure of epigallocatechin binding with alpha-lactalbumin	2021-04-05	2023-11-08	Ma, J.,Yao, Q.,Chen, X.,Lv, C.,Zang, J.,Zhao, G.	Weak Binding of Epigallocatechin to alpha-Lactalbumin Greatly Improves Its Stability and Uptake by Caco-2 Cells.	J.Agric.Food Chem.	2021	69	8482	8491	
7XQS		The structure of FLA-K*00701/KP-CoV-9	2022-05-08	2023-11-08	Qiao, P.W.,Yue, C.,Peng, W.Y.,Liu, K.F.,Huo, S.T.,Zhang, D.,Chai, Y.,Qi, J.X.,Sun, Z.Y.,Gao, G.F.,Liu, W.J.,Wu, G.Z.	Analysis of the characteristics of feline major histocompatibility complex class I molecules cross-presenting coronavirus peptides	To Be Published	0	0	0	0	
7XQT		The structure of FLA-K*00701/KP-FECV-11	2022-05-08	2023-11-08	Qiao, P.W.,Yue, C.,Peng, W.Y.,Liu, K.F.,Huo, S.T.,Zhang, D.,Chai, Y.,Qi, J.X.,Sun, Z.Y.,Gao, G.F.,Liu, W.J.,Wu, G.Z.	Analysis of the characteristics of feline major histocompatibility complex class I molecules cross-presenting coronavirus peptides	To Be Published	0	0	0	0	
7XQU		The structure of FLA-E*00301/EM-FECV-10	2022-05-08	2023-11-08	Qiao, P.W.,Yue, C.,Peng, W.Y.,Liu, K.F.,Huo, S.T.,Zhang, D.,Chai, Y.,Qi, J.X.,Sun, Z.Y.,Gao, G.F.,Liu, W.J.,Wu, G.Z.	Analysis of the characteristics of feline major histocompatibility complex class I molecules cross-presenting coronavirus peptides	To Be Published	0	0	0	0	
7Y8D	38368459	Crystal structure of cp1 bound BCLxl	2022-06-23	2023-11-15	Li, F.,Liu, J.,Liu, C.,Liu, Z.,Peng, X.,Huang, Y.,Chen, X.,Sun, X.,Wang, S.,Chen, W.,Xiong, D.,Diao, X.,Wang, S.,Zhuang, J.,Wu, C.,Wu, D.	Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.	Nat Commun	2024	15	1476	1476	
7Y90	38368459	Crystal Structure Analysis of cp1 bound BCL2	2022-06-24	2023-11-15	Li, F.,Liu, J.,Liu, C.,Liu, Z.,Peng, X.,Huang, Y.,Chen, X.,Sun, X.,Wang, S.,Chen, W.,Xiong, D.,Diao, X.,Wang, S.,Zhuang, J.,Wu, C.,Wu, D.	Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.	Nat Commun	2024	15	1476	1476	
7YA5	38368459	Crystal structure analysis of cp1 bound BCL2/G101V	2022-06-27	2023-11-15	Li, F.,Liu, J.,Liu, C.,Liu, Z.,Peng, X.,Huang, Y.,Chen, X.,Sun, X.,Wang, S.,Chen, W.,Xiong, D.,Diao, X.,Wang, S.,Zhuang, J.,Wu, C.,Wu, D.	Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.	Nat Commun	2024	15	1476	1476	
7YAA	38368459	Crystal structure analysis of cp3 bound BCLxl	2022-06-27	2023-11-15	Li, F.,Liu, J.,Liu, C.,Liu, Z.,Peng, X.,Huang, Y.,Chen, X.,Sun, X.,Wang, S.,Chen, W.,Xiong, D.,Diao, X.,Wang, S.,Zhuang, J.,Wu, C.,Wu, D.	Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.	Nat Commun	2024	15	1476	1476	
7YB7	38368459	anti-apoptotic protein BCL-2-M12	2022-06-29	2023-11-15	Li, F.,Liu, J.,Liu, C.,Liu, Z.,Peng, X.,Huang, Y.,Chen, X.,Sun, X.,Wang, S.,Chen, W.,Xiong, D.,Diao, X.,Wang, S.,Zhuang, J.,Wu, C.,Wu, D.	Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.	Nat Commun	2024	15	1476	1476	
8HCU		Crystal structure of BCOR/PCGF1/KDM2B complex	2022-11-03	2023-11-15	Shen, F.,Chen, R.,Xu, J.,Liu, J.	Crystal structure of BCOR/PCGF1/KDM2B complex	to be published	0	0	0	0	
8HEO		Crystal structure of SIAH1 SBD bound to Axin2 peptide	2022-11-08	2023-11-15	Yan, X.X.,Tian, L.F.	Crystal structure of SIAH1 SBD bound to Axin2 peptide	To Be Published	0	0	0	0	
8IR2	37748650	Crystal structure of the SLF1 BRCT domain in complex with a Rad18 peptide containing pS442 and pS444	2023-03-17	2023-11-15	Huang, W.,Qiu, F.,Zheng, L.,Shi, M.,Shen, M.,Zhao, X.,Xiang, S.	Structural insights into Rad18 targeting by the SLF1 BRCT domains.	J.Biol.Chem.	2023	299	105288	105288	
8JF9	37779101	Crystal structure of 3-oxoacyl-ACP reductase FabG from Helicobacter pylori	2023-05-17	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8JFA	37779101	Crystal structure of 3-oxoacyl-ACP reductase FabG in complex with NADPH from Helicobacter pylori	2023-05-17	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8JFG	37779101	Crystal structure of 3-oxoacyl-ACP reductase FabG in complex with NADP+ and 3-keto-octanoyl-ACP from Helicobacter pylori	2023-05-18	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8JFH	37779101	Crystal structure of 3-oxoacyl-ACP reductase FabG in complex with NADP+ and 3-keto-octanoyl-ACP from Helicobacter pylori in an inactive form that priors the acyl substrate delivery	2023-05-18	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8JFI	37779101	Crystal structure of 3-oxoacyl-ACP reductase FabG in complex with NADP+ and 3-keto-hexanoyl-ACP from Helicobacter pylori	2023-05-18	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8JFJ	37779101	Crystal structure of enoyl-ACP reductase FabI from Helicobacter pylori	2023-05-18	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8JFM	37779101	Crystal structure of enoyl-ACP reductase FabI in complex with NADH from Helicobacter pylori	2023-05-18	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8JFN	37779101	Crystal structure of enoyl-ACP reductase FabI in complex with NAD+ and crotonyl-ACP from Helicobacter pylori	2023-05-18	2023-11-15	Zhou, J.,Zhang, L.,Wang, Y.,Song, W.,Huang, Y.,Mu, Y.,Schmitz, W.,Zhang, S.Y.,Lin, H.,Chen, H.Z.,Ye, F.,Zhang, L.	The Molecular Basis of Catalysis by SDR Family Members Ketoacyl-ACP Reductase FabG and Enoyl-ACP Reductase FabI in Type-II Fatty Acid Biosynthesis.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
8WSQ		A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein.	2023-10-17	2023-11-15	Xu, S.Y.,Chai, Y.	A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein.	To Be Published	0	0	0	0	
8HGD		Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei	2022-11-14	2023-11-22	Jiang, Y.,Cong, Z.	Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei	To Be Published	0	0	0	0	
8HGE		Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei in complex with 12-hydroxydodecanoic acid	2022-11-14	2023-11-22	Jiang, Y.,Cong, Z.	Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei in complex with 12-hydroxydodecanoic acid	To Be Published	0	0	0	0	
8HTD	37945894	Crystal structure of an effector from Chromobacterium violaceum in complex with ubiquitin	2022-12-21	2023-11-22	Tan, J.,Xu, Y.,Wang, X.,Yan, F.,Xian, W.,Liu, X.,Chen, Y.,Zhu, Y.,Zhou, Y.	Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs.	Nat.Chem.Biol.	2024	20	463	472	
8HTF	37945894	Crystal structure of an effector in complex with ubiquitin	2022-12-21	2023-11-22	Tan, J.,Xu, Y.,Wang, X.,Yan, F.,Xian, W.,Liu, X.,Chen, Y.,Zhu, Y.,Zhou, Y.	Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs.	Nat.Chem.Biol.	2024	20	463	472	
8J5J	37804113	The crystal structure of bat coronavirus RsYN04 RBD bound to the antibody S43	2023-04-23	2023-11-22	Zhao, R.,Niu, S.,Han, P.,Gao, Y.,Liu, D.,Luo, C.,Liu, H.,Liu, B.,Xu, Y.,Qi, J.,Chen, Z.,Shi, W.,Wu, L.,Gao, G.F.,Wang, Q.	Cross-species recognition of bat coronavirus RsYN04 and cross-reaction of SARS-CoV-2 antibodies against the virus.	Zool.Res.	2023	44	1015	1025	
8W4S	37918035	Crystal structure of PDE5A in complex with CVT-313	2023-08-24	2023-11-22	Liu, J.,Zhang, X.,Chen, G.,Shao, Q.,Zou, Y.,Li, Z.,Su, H.,Li, M.,Xu, Y.	Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.	Eur.J.Med.Chem.	2023	262	115893	115893	
8WUG		The Crystal Structure of JMJD2D from Biortus.	2023-10-20	2023-11-22	Wang, F.,Cheng, W.,Yuan, Z.,Lin, D.,Guo, S.	The Crystal Structure of JMJD2D from Biortus.	To Be Published	0	0	0	0	
8I3X		Rice APIP6-RING homodimer	2023-01-18	2023-11-29	Zheng, Y.,Zhang, X.,Liu, Y.,Zhu, T.,Wu, X.,Ning, Y.,Liu, J.,Wang, D.	Crystal structure of rice APIP6 reveals a new dimerization mode of RING-type E3 ligases that facilities the construction of its working model	Phytopathol Res	2023	5	0	0	
8W75	37995940	Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase	2023-08-30	2023-11-29	Yang, J.,Chen, X.,Jin, S.,Ding, J.	Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria.	J.Biol.Chem.	2023	300	105491	105491	
8W78	37995940	Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase in complex with FAD and 2-oxoglutarate	2023-08-30	2023-11-29	Yang, J.,Chen, X.,Jin, S.,Ding, J.	Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria.	J.Biol.Chem.	2023	300	105491	105491	
7XXE		Crystal structure of spFft3 C-terminal truncation	2022-05-30	2023-12-06	Nan, Z.,Tao, J.,Yangao, H.	Crystal structure of spFft3 C-terminal truncation	To Be Published	0	0	0	0	
7XYD		Crystal structure of TMPRSS2 in complex with Nafamostat	2022-06-01	2023-12-06	Wang, H.,Duan, Y.,Liu, X.,Sun, L.,Yang, H.	Crystal structure of TMPRSS2 in complex with Nafamostat	To Be Published	0	0	0	0	
7YLL	37683741	Crystal structure of TTEDbh	2022-07-26	2023-12-06	Tian, L.F.,Gao, H.,Yang, S.,Liu, Y.P.,Li, M.,Xu, W.,Yan, X.X.	Structure and function of extreme TLS DNA polymerase TTEDbh from Thermoanaerobacter tengcongensis.	Int.J.Biol.Macromol.	2023	253	126770	126770	
8HO2		crystal structure of Norcoclaurine synthase from Chinese lotus (Nelumbo nucicera)	2022-12-09	2023-12-06	Liao, L.J.,Zhao, Y.C.	The crystal structure of Norcoclaurine synthase from Chinese lotus (Nelumbo nucicera)  was investigated to determine its catalytic mechanism and enantioselectivity.	To Be Published	0	0	0	0	
8KHQ	38058600	Bifunctional sulfoxide synthase OvoA_Th2 in complex with histidine and cysteine	2023-08-22	2023-12-06	Wang, X.,Hu, S.,Wang, J.,Zhang, T.,Ye, K.,Wen, A.,Zhu, G.,Vegas, A.,Zhang, L.,Yan, W.,Liu, X.,Liu, P.	Biochemical and Structural Characterization of OvoA Th2 : A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis.	Acs Catalysis	2023	13	15417	15426	
8WOJ		Structure of RxLR121 effector from phytophthora capsici	2023-10-07	2023-12-06	Yang, C.C.,Zhang, X.G.	Structure of RxLR121 effector from phytophthora capsici	To be published	0	0	0	0	
8HEI		Crystal structure of CTSB in complex with E64d	2022-11-08	2023-12-13	Wang, H.,Li, D.,Sun, L.,Yang, H.	Crystal structure of CTSB in complex with E64d	To Be Published	0	0	0	0	
8HET		Crystal structure of CTSL in complex with E64d	2022-11-08	2023-12-13	Wang, H.,Shao, M.,Sun, L.,Yang, H.	Crystal structure of CTSB in complex with K777	To Be Published	0	0	0	0	
8HFV		Crystal structure of CTSL in complex with K777	2022-11-12	2023-12-13	Wang, H.,Shao, M.,Sun, L.,Yang, H.	Crystal structure of CTSL in complex with K777	To Be Published	0	0	0	0	
8HOK		crystal structure of UGT71AP2	2022-12-10	2023-12-13	Wang, Z.L.,He, C.,Li, F.,Qiao, X.,Ye, M.	crystal structure of UGT71AP2	To Be Published	0	0	0	0	
8HOT		Crystal structure of the P450 BM3 heme domain mutant F87A in complex with NH2-C7-Phe-Phe	2022-12-10	2023-12-13	Jiang, Y.,Dong, S.,Feng, Y.,Cong, Z.	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with NH2-C7-Phe-Phe	To Be Published	0	0	0	0	
8HQ1		Crystal Structure Of Human Lgi1-Adam22 Complex In Space Group C2	2022-12-13	2023-12-13	Liu, H.L.,Lin, Z.H.,Xu, F.	Structure Of Human Lgi1-Adam22 Complex In Space Group C2	To Be Published	0	0	0	0	
8HQ2		Crystal structure of human ADAM22 in complex with human LGI1 mutant	2022-12-13	2023-12-13	Liu, H.,Lin, Z.,Xu, F.	Crystal structure of human ADAM22 in complex with human LGI1 mutant	To Be Published	0	0	0	0	
8JNX		alkaline amylase Amy703 with truncated of N-terminus domain	2023-06-06	2023-12-13	Xiang, L.,Zhang, G.,Zhou, J.	Truncation of N-terminus domain of alkaline a-amylase to form a unique dimer leads to improved activity and stability and decreased calcium ion dependence	To Be Published	0	0	0	0	
8HNQ		The structure of a alcohol dehydrogenase AKR13B2 with NADP	2022-12-08	2023-12-20	Chen, M.,Yang, H.,Lu, F.	The structure of AKR13B2	To Be Published	0	0	0	0	
8HOE		Apo structure of HopBF1 kinase from Ewingella americana	2022-12-09	2023-12-20	Wang, C.C.	Apo structure of HopBF1 kinase from Ewingella americana	To Be Published	0	0	0	0	
8HQ4		B27 in complex with CRM1-Ran-RanBP1	2022-12-13	2023-12-20	Lei, Y.,Sun, Q.	B27 in complex with CRM1-Ran-RanBP1	To Be Published	0	0	0	0	
8HQ5		G6 in complex with CRM1-Ran-RanBP1	2022-12-13	2023-12-20	Sun, Q.,Lei, Y.	F1 in complex with CRM1-Ran-RanBP1	To Be Published	0	0	0	0	
8HQL		Crystal structure of mouse SNX25 PX domain	2022-12-13	2023-12-20	Yu, Z.,Xu, J.,Liu, J.	Crystal structure of mouse SNX25 PX domain	To Be Published	0	0	0	0	
8HQV		The complex structure of COPI cargo sorting module with HCoV-OC43 Spike KTSHxx sorting motif	2022-12-14	2023-12-20	Li, Y.Q.,Yang, M.R.,Nan, Y.N.,Wang, J.M.,Guo, J.J.,He, P.F.,Dai, W.X.,Zhou, S.Q.,Wang, S.J.,Zhang, Y.,Ma, W.F.	Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations	To Be Published	0	0	0	0	
8HQX		The complex structure of COPI cargo sorting module with TAT-WDM peptide	2022-12-14	2023-12-20	Ma, W.F.,Nan, Y.N.,Yang, M.R.,Li, Y.Q.	The complex structure of COPI cargo sorting module with TAT-WDM peptide	To Be Published	0	0	0	0	
8HR0		The complex structure of COPII coat with HCoV-OC43 DD sorting motif	2022-12-14	2023-12-20	Li, Y.Q.,Yang, M.R.,Nan, Y.N.,Wang, J.M.,Guo, J.J.,He, P.F.,Dai, W.X.,Zhou, S.Q.,Wang, S.J.,Zhang, Y.,Ma, W.F.	Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations	To Be Published	0	0	0	0	
8HSO		CRYSTAL STRUCTURE OF A MUTANT MYLU-B-67 FOR 2.2 ANGSTROM, 52M 53Q 54Q 55P 56W DELETED	2022-12-20	2023-12-20	Wang, S.Q.,Zhang, N.Z.	CRYSTAL STRUCTURE OF A MUTANT MYLU-B-67 FOR 2.2 ANGSTROM, 52M 53Q 54Q 55P 56W  DELETED	To Be Published	0	0	0	0	
8HSW		CRYSTAL STRUCTURE OF BAT MHC CLASS I MYLU-B-67 FOR 2.1 ANGSTROM	2022-12-20	2023-12-20	Wang, S.Q.,Zhang, N.Z.	CRYSTAL STRUCTURE OF BAT MHC CLASS I MYLU-B-67 FOR 2.1 ANGSTROM	To Be Published	0	0	0	0	
8HT9		CRYSTAL STRUCTURE OF BAT MHC CLASS I MYLU-B-67 FOR 2.2 ANGSTROM	2022-12-20	2023-12-20	Wang, S.Q.,Zhang, N.Z.	CRYSTAL STRUCTURE OF BAT MHC CLASS I MYLU-B-67 FOR 2.2 ANGSTROM	To Be Published	0	0	0	0	
8HWR		Crystal structure of AtHPPD-Y191193 complex	2023-01-02	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y191193 complex	To Be Published	0	0	0	0	
8HX2		Crystal structure of AtHPPD-Y18405 complex	2023-01-03	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18405 complex	To Be Published	0	0	0	0	
8HX4		Crystal structure of AtHPPD-Y18549 complex	2023-01-03	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18549 complex	To Be Published	0	0	0	0	
8HXF		Crystal structure of AtHPPD-Y181188 complex	2023-01-04	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y181188 complex	To Be Published	0	0	0	0	
8HXG		Crystal structure of AtHPPD-Y14116 complex	2023-01-04	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y14116 complex	To Be Published	0	0	0	0	
8HXH		Crystal structure of AtHPPD-Y18024 complex	2023-01-04	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18024 complex	To Be Published	0	0	0	0	
8HYM		Crystal structure of AtHPPD-Y18030 complex	2023-01-07	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18030 complex	To Be Published	0	0	0	0	
8HYO		Crystal structure of AtHPPD-Y18031 complex	2023-01-07	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18031 complex	To Be Published	0	0	0	0	
8HYP		Crystal structure of AtHPPD-Y18400 complex	2023-01-07	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18400 complex	To Be Published	0	0	0	0	
8HYS		Crystal structure of AtHPPD-Y19802 complex	2023-01-07	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y19802 complex	To Be Published	0	0	0	0	
8HZ6		Crystal structure of AtHPPD-QRY2089 complex	2023-01-08	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-QRY2089 complex	To Be Published	0	0	0	0	
8HZ7		Crystal structure of AtHPPD-Y181135 complex	2023-01-08	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y181135 complex	To Be Published	0	0	0	0	
8HZ9		Crystal structure of AtHPPD-Y181136 complex	2023-01-08	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y181136 complex	To Be Published	0	0	0	0	
8HZA		Crystal structure of AtHPPD-YH20326 complex	2023-01-08	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-YH20326 complex	To Be Published	0	0	0	0	
8HZU		Crystal structure of AtHPPD-XHD complex	2023-01-09	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-XHD complex	To Be Published	0	0	0	0	
8I0G		Crystal structure of AtHPPD-Y19543 complex	2023-01-10	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y19543 complex	To Be Published	0	0	0	0	
8I0Y		Crystal structure of AtHPPD-Y191713 complex	2023-01-11	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y191713 complex	To Be Published	0	0	0	0	
8I15		Crystal structure of AtHPPD-YH20335 complex	2023-01-12	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-YH20335 complex	To Be Published	0	0	0	0	
8I2P		Crystal structure of AtHPPD-Y19060 complex	2023-01-14	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y19060 complex	To Be Published	0	0	0	0	
8I2S		Crystal structure of AtHPPD-Y18979 complex	2023-01-15	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18979 complex	To Be Published	0	0	0	0	
8I2U		Crystal structure of AtHPPD-YH20282 complex	2023-01-15	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-YH20282 complex	To Be Published	0	0	0	0	
8I36		Crystal structure of AtHPPD-Y18980 complex	2023-01-16	2023-12-20	Dong, J.,Lin, H.-Y.,Yang, G.-F.	Crystal structure of AtHPPD-Y18980 complex	To Be Published	0	0	0	0	
7Y3N	38109549	Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56	2022-06-11	2023-12-27	Rao, X.,Zhao, R.,Tong, Z.,Guo, S.,Peng, W.,Liu, K.,Li, S.,Wu, L.,Tong, J.,Chai, Y.,Han, P.,Wang, F.,Jia, P.,Li, Z.,Zhao, X.,Li, D.,Zhang, R.,Zhang, X.,Zou, W.,Li, W.,Wang, Q.,Gao, G.F.,Wu, Y.,Dai, L.,Gao, F.	Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
7Y3O	38109549	Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody BIOLS56	2022-06-11	2023-12-27	Rao, X.,Zhao, R.,Tong, Z.,Guo, S.,Peng, W.,Liu, K.,Li, S.,Wu, L.,Tong, J.,Chai, Y.,Han, P.,Wang, F.,Jia, P.,Li, Z.,Zhao, X.,Li, D.,Zhang, R.,Zhang, X.,Zou, W.,Li, W.,Wang, Q.,Gao, G.F.,Wu, Y.,Dai, L.,Gao, F.	Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2.	Proc.Natl.Acad.Sci.USA	2023	120	0	0	
8GSJ		APC-Asef tripeptide inhibitor	2022-09-06	2023-12-27	Zhang, J.,Wang, X.F.,Song, K.	APC-Asef tripeptide inhibitor	To Be Published	0	0	0	0	
8HQU		Crystal structure of the major sperm protein domain of SCS2 from saccharomyces cerevisiae	2022-12-14	2023-12-27	Xu, T.,Wang, C.C.	Structural insights into the major sperm protein domain of SCS2 from saccharomyces cerevisiae	To Be Published	0	0	0	0	
8HUH		Crystal structure of T2R-TTL-3a complex	2022-12-23	2023-12-27	Wang, Y.X.,Chen, J.J.	Crystal structure of T2R-TTL-3a complex	To Be Published	0	0	0	0	
8HUI		Crystal structure of DFA I-forming Inulin Lyase from Streptomyces peucetius subsp. caesius ATCC 27952 in complex with GF4, DFA I, and fructose	2022-12-24	2023-12-27	Cheng, M.,Rao, Y.J.,Mu, W.M.	Crystal structure of DFA I-forming Inulin Lyase from Streptomyces peucetius subsp. caesius ATCC 27952 in complex with GF4, DFA I, and fructose	To Be Published	0	0	0	0	
8TBU	38109501	Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator Compound 12	2023-06-29	2023-12-27	Liu, T.,Padyana, A.K.,Judd, E.T.,Jin, L.,Hammoudeh, D.,Kung, C.,Dang, L.	Structure-Based Design of AG-946, a Pyruvate Kinase Activator.	Chemmedchem	2024	19	0	0	
7YBF		Crystal structure of inner membrane protein Sad1 in complex with histone H2A-H2B	2022-06-29	2024-01-03	Sun, W.,Hu, C.,Ye, X.,Li, X.,Chen, Y.	Crystal structure of inner membrane protein Sad1 in complex with histone H2A-H2B	To Be Published	0	0	0	0	
8HXQ	38062078	Nanobody1 in complex with human BCMA ECD	2023-01-05	2024-01-03	Sun, Y.,Yang, X.N.,Yang, S.S.,Lyu, Y.Z.,Zhang, B.,Liu, K.W.,Li, N.,Cui, J.C.,Huang, G.X.,Liu, C.L.,Xu, J.,Mi, J.Q.,Chen, Z.,Fan, X.H.,Chen, S.J.,Chen, S.	Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity.	Signal Transduct Target Ther	2023	8	445	445	
8IHO	37239980	Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors	2023-02-23	2024-01-03	Wang, Q.,Chen, G.,He, J.,Li, J.,Xiong, M.,Su, H.,Li, M.,Hu, H.,Xu, Y.	Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease.	Int J Mol Sci	2023	24	0	0	
8IPI	38291322	The apo structure of human mitochondrial methyltransferase METTL15	2023-03-14	2024-01-03	Lv, M.,Zhou, W.,Hao, Y.,Li, F.,Zhang, H.,Yao, X.,Shi, Y.,Zhang, L.	Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.	Cell Discov	2024	10	11	11	
8IPM	38291322	The structure of human mitochondrial methyltransferase METTL15 with h44_RNA, RBFA and SAM	2023-03-14	2024-01-03	Lv, M.,Zhou, W.,Hao, Y.,Li, F.,Zhang, H.,Yao, X.,Shi, Y.,Zhang, L.	Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.	Cell Discov	2024	10	11	11	
8JQE	38141024	Structure of CmCBDA in complex with Mn2+ and glycerol	2023-06-14	2024-01-03	Hu, S.,Xu, L.,Xie, C.,Hong, J.	Structural Insights into the Catalytic Activity of Cyclobacterium marinum N -Acetylglucosamine Deacetylase.	J.Agric.Food Chem.	2024	72	783	793	
8K5N	38109261	Discovery of Novel PD-L1 Inhibitors That Induce Dimerization and Degradation of PD-L1 Based on Fragment Coupling Strategy	2023-07-22	2024-01-03	Wang, K.,Zhang, X.,Cheng, Y.,Qi, Z.,Ye, K.,Zhang, K.,Jiang, S.,Liu, Y.,Xiao, Y.,Wang, T.	Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy.	J.Med.Chem.	2023	66	16807	16827	
8WWU		1-naphthylamine GS in complex with AMP PNP	2023-10-26	2024-01-03	Zhang, S.T.,Zhou, N.Y.	Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation	To Be Published	0	0	0	0	
8WWV		1-naphthylamine GS in complex with ADP and MetSox-P	2023-10-26	2024-01-03	Zhang, S.T.,Zhou, N.Y.	Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation	To Be Published	0	0	0	0	
8X6Z		1-naphthylamine GS from Pseudomonas sp. JS3066	2023-11-22	2024-01-03	Zhou, N.Y.,Zhang, S.T.	Structure of 1-naphthylamine glutamine synthetase at 2.95 Angstroms resolution.	To Be Published	0	0	0	0	
8HWY		Ancestral imine reductase mutant N559_M6	2023-01-03	2024-01-10	Zhu, X.X.,Zheng, G.W.	The evolution of stereoselectivity in imine reductase	To Be Published	0	0	0	0	
8HZ4		The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate	2023-01-08	2024-01-10	Shen, J.,Wu, W.,Xu, X.	The tetrameric structure of biotin carboxylase from  Chloroflexus aurantiacus in complex with bicarbonate	To be published	0	0	0	0	
8HZ5		The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus	2023-01-08	2024-01-10	Shen, J.,Wu, W.,Xu, X.	The homodimer of a biotin carboxylase isoform from  chloroflexus aurantiacus	To be published	0	0	0	0	
7YW5	38153123	Crystal Structure of the ITS1 processing by human ribonuclease ISG20L2 with mutation D327A	2022-08-21	2024-01-17	Ma, Y.,Wang, J.,He, X.,Liu, Y.,Zhen, S.,An, L.,Yang, Q.,Niu, F.,Wang, H.,An, B.,Tai, X.,Yan, Z.,Wu, C.,Yang, X.,Liu, X.	Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the processing of 18S precursor ribosomal RNA.	Nucleic Acids Res.	2024	52	1878	1895	
8HS0		The mutant structure of DHAD V178W	2022-12-16	2024-01-17	Zhou, J.,Zang, X.,Tang, Y.,Yan, Y.	The mutant structure of DHAD	To Be Published	0	0	0	0	
8HS7		Crystal structure of Vesicle-associated membrane protein-associated protein SCS2 from yeast	2022-12-17	2024-01-17	Xu, T.	Crystal structure of the major sperm protein domain of SCS2 from saccharomyces cerevisiae	To Be Published	0	0	0	0	
8HUZ		the structure of trans-editing factor ProX	2022-12-25	2024-01-17	Yuan, C.,Xiao, Y.,Zhou, X.,Chen, M.	the structure of trans-editing factor ProX	To Be Published	0	0	0	0	
8HW0		the structure of AKR6D1	2022-12-28	2024-01-17	Chen, M.,Yang, H.,Lv, F.	structure of AKR6D1	To Be Published	0	0	0	0	
8HWN		aldo-keto reductase DepB	2022-12-31	2024-01-17	Yang, H.,Lu, F.,Chen, M.	The structure of DepB capable of DON detoxification	To Be Published	0	0	0	0	
8WAB		Crystal structure of a chondroitin sulfate-binding carbohydrate binding module of a chondroitinase	2023-09-07	2024-01-17	Liu, G.C.,Chang, Y.G.	Structure of a carbohydrate binding module at 2.2 Angstroms resolution	To Be Published	0	0	0	0	
8WIL	38296832	Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D55 construct)	2023-09-24	2024-01-17	Wang, X.,Jing, X.,Shi, J.,Liu, Q.,Shen, S.,Cheung, P.P.,Wu, J.,Deng, F.,Gong, P.	A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase.	Nucleic Acids Res.	2024	52	3278	3290	
8XMZ		Crystal structure of a novel porphyran-binding carbohydrate binding module	2023-12-28	2024-01-17	Mei, X.W.,Chang, Y.G.	Crystal structure of a novel porphyran-binding carbohydrate binding module	To Be Published	0	0	0	0	
7YAV		Crystal structure of Diels-Alderase MaDA1	2022-06-28	2024-01-24	Lei, X.G.,Ding, Q.,Guo, N.X.,Yang, J.,Fan, J.P.	Crystal structure of Diels-Alderase MaDA1	To Be Published	0	0	0	0	
8HYB		Crystal structure of B1 IMP-1 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid	2023-01-06	2024-01-24	Yan, Y.-H.,Zhu, K.-R.,Yang, L.-L.,Li, G.-B.	2-Aminothiazole-4-carboxylic acids as cross-class metallo-beta-lactamase inhibitors by mimicking beta-lactam hydrolysate binding	To Be Published	0	0	0	0	
8I3E		Crystal structure of ELKS1 in complex with Piccolo	2023-01-17	2024-01-24	Qiu, H.,Wu, X.,Cai, Q.,Ganzella, M.,Jahn, R.,Zhang, M.	Short-distance vesicle transport via phase separation	To Be Published	0	0	0	0	
8IMS	38178633	Crystal structure of TRAF7 coiled-coil domain	2023-03-07	2024-01-24	Song, X.,Hu, R.,Chen, Y.,Xiao, M.,Zhang, H.,Wu, S.,Lu, Q.	The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development.	J Mol Cell Biol	2024	0	0	0	
8INA		Crystal structure of UGT74AN3-UDP	2023-03-09	2024-01-24	Huang, W.,Zhang, X.,Li, J.,Lv, J.,Wang, Y.,He, Y.,Song, J.,Agren, H.,Jiang, R.,Deng, Z.,Long, F.	Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3	Acs Catalysis	2024	14	475	488	
8IND		Crystal structure of UGT74AN3-UDP-RES	2023-03-09	2024-01-24	Huang, W.,Zhang, X.,Li, J.,Lv, J.,Wang, Y.,He, Y.,Song, J.,Agren, H.,Jiang, R.,Deng, Z.,Long, F.	Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3	Acs Catalysis	2024	14	475	488	
8INO		Crystal structure of UGT74AN3 in complex UDP and PER	2023-03-10	2024-01-24	Huang, W.,Zhang, X.,Li, J.,Lv, J.,Wang, Y.,He, Y.,Song, J.,Agren, H.,Jiang, R.,Deng, Z.,Long, F.	Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3	Acs Catalysis	2024	14	475	488	
8INV		Crystal structure of UGT74AN3-UDP-BUF	2023-03-10	2024-01-24	Huang, W.,Zhang, X.,Li, J.,Lv, J.,Wang, Y.,He, Y.,Song, J.,Agren, H.,Jiang, R.,Deng, Z.,Long, F.	Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3	Acs Catalysis	2024	14	475	488	
8JBR		Structure of McyA2-CAPCP	2023-05-09	2024-01-24	Peng, Y.J.	Structure of McyA2-CAPCP	To Be Published	0	0	0	0	
8JNK	38158383	Crystal structure of human ALKBH3 bound to ssDNA through active site crosslink	2023-06-06	2024-01-24	Zhang, L.,Duan, H.C.,Paduch, M.,Hu, J.,Zhang, C.,Mu, Y.,Lin, H.,He, C.,Kossiakoff, A.A.,Jia, G.,Zhang, L.	The Molecular Basis of Human ALKBH3 Mediated RNA N 1 -methyladenosine (m 1 A) Demethylation.	Angew.Chem.Int.Ed.Engl.	2024	63	0	0	
8JNR	38158383	Crystal structure of human ALKBH3 bound to 3mC containing ssDNA through distal crosslink	2023-06-06	2024-01-24	Zhang, L.,Duan, H.C.,Paduch, M.,Hu, J.,Zhang, C.,Mu, Y.,Lin, H.,He, C.,Kossiakoff, A.A.,Jia, G.,Zhang, L.	The Molecular Basis of Human ALKBH3 Mediated RNA N 1 -methyladenosine (m 1 A) Demethylation.	Angew.Chem.Int.Ed.Engl.	2024	63	0	0	
8JU7		Structure of Pseudomonas aeruginosa ParS sensor domain	2023-06-25	2024-01-24	Zhao, N.L.,Zhu, Z.Q.,Song, Y.J.,Bao, R.	Dynorphin-sensing two-component systems ParRS and CprRS in Pseudomonas aeruginosa pathogenesis	To Be Published	0	0	0	0	
8WRK		glycosyltransferase UGT74AN3	2023-10-15	2024-01-24	Huang, W.,Zhang, X.,Li, J.,Lv, J.,Wang, Y.,He, Y.,Song, J.,Agren, H.,Jiang, R.,Deng, Z.,Long, F.	Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3	Acs Catalysis	2024	14	475	488	
8XAS	38198526	Crystal structure of AtARR1-DBD in complex with a DNA fragment	2023-12-05	2024-01-24	Zhou, C.M.,Li, J.X.,Zhang, T.Q.,Xu, Z.G.,Ma, M.L.,Zhang, P.,Wang, J.W.	The structure of B-ARR reveals the molecular basis of transcriptional activation by cytokinin.	Proc.Natl.Acad.Sci.USA	2024	121	0	0	
8XAT	38198526	Crystal structure of AtARR1(RD-DBD)	2023-12-05	2024-01-24	Zhou, C.M.,Li, J.X.,Zhang, T.Q.,Xu, Z.G.,Ma, M.L.,Zhang, P.,Wang, J.W.	The structure of B-ARR reveals the molecular basis of transcriptional activation by cytokinin.	Proc.Natl.Acad.Sci.USA	2024	121	0	0	
8WBO	38199576	Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] mutant D18N complexed with sulfate ions	2023-09-10	2024-01-31	Dong, S.,Xuan, J.,Feng, Y.,Cui, Q.	Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid.	J.Biol.Chem.	2024	300	105635	105635	
8CB2		A complex of cagX and cagY components of Helicobacter pylori type IV secretion system	2023-01-25	2024-02-07	Isupov, M.N.,Jiang, M.	A complex of cagX and cagY components of  Helicobacter pylori type IV secretion system	To Be Published	0	0	0	0	
8I0B		The crystal structure of human glutamate receptor 2 in complex with LT-102	2023-01-10	2024-02-07	Qi, X.Y.,Wu, C.Y.	Structure of the human GluA2 LBD in complex with LT-102	To Be Published	0	0	0	0	
8I8F	38336327	Crystal structure of NDM-1 at pH5.5 (Succinate) in complex with hydrolyzed compound 1	2023-02-04	2024-02-07	Shi, X.,Dai, Y.,Lan, Z.,Wang, S.,Cui, L.,Xiao, C.,Zhao, K.,Li, X.,Liu, W.,Zhang, Q.	Interplay between the beta-lactam side chain and an active-site mobile loop of NDM-1 in penicillin hydrolysis as a potential target for mechanism-based inhibitor design.	Int.J.Biol.Macromol.	2024	262	130041	130041	
8IXZ	38103556	Structure of Acb2 complexed with 3',2'-cGAMP	2023-04-03	2024-02-07	Cao, X.,Xiao, Y.,Huiting, E.,Cao, X.,Li, D.,Ren, J.,Fedorova, I.,Wang, H.,Guan, L.,Wang, Y.,Li, L.,Bondy-Denomy, J.,Feng, Y.	Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.	Mol.Cell	2024	84	375	0	
8IY1	38103556	Structure of Acb2 complexed with cAAG	2023-04-03	2024-02-07	Cao, X.,Xiao, Y.,Huiting, E.,Cao, X.,Li, D.,Ren, J.,Fedorova, I.,Wang, H.,Guan, L.,Wang, Y.,Li, L.,Bondy-Denomy, J.,Feng, Y.	Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.	Mol.Cell	2024	84	375	0	
8IY2	38103556	Structure of Acb2 complexed with 3',3'-cGAMP and cAAA	2023-04-03	2024-02-07	Cao, X.,Xiao, Y.,Huiting, E.,Cao, X.,Li, D.,Ren, J.,Fedorova, I.,Wang, H.,Guan, L.,Wang, Y.,Li, L.,Bondy-Denomy, J.,Feng, Y.	Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.	Mol.Cell	2024	84	375	0	
8JJN		Structure of SenB in complex with UDP-Glc and PO4- at 1.98 Angstroms resolution	2023-05-31	2024-02-07	Huang, W.,Long, F.	Structure of SenB in complex with UDP-Glc and PO4- at 1.98 Angstroms resolution	To Be Published	0	0	0	0	
8JJQ		Structure of SenB in complex with UDP-GalNAc at 1.64 Angstroms resolution	2023-05-31	2024-02-07	Wei, H.,Feng, L.	Structure of SenB in complex with UDP-GalNAc at 1.64 Angstroms resolution	To Be Published	0	0	0	0	
8JJT		Structure of SenB in complex with UDP-GlcNAc at 1.88 Angstroms resolution	2023-05-31	2024-02-07	Wei, H.,Feng, L.	Structure of SenB in complex with UDP-GlcNAc at 1.88 Angstroms resolution	To be published	0	0	0	0	
8XIY		Crystal structure of an omega-transaminase mutant I77L/Q97E/H210N/N245D from Aspergillus terreus in complex with PLP	2023-12-20	2024-02-07	He, Y.C.	Efficient bioamination with an omega-transaminase mutant from Aspergillus terreus	To Be Published	0	0	0	0	
8XIZ		Crystal structure of an epoxide hydrolase mutant A250IC/L344V from Aspergillus usamii E001 at 2.17 Angstroms resolution	2023-12-20	2024-02-07	Hu, D.,Lu, Z.Y.	Directed evolution of an epoxide hydrolase and its structural mechanism for the enantioselectivity improvement toward chiral ortho-fluorostyrene oxide	To Be Published	0	0	0	0	
8INJ		Crystal structure of UGT74AN3-UDP-DIG	2023-03-10	2024-02-14	Feng, L.,Wei, H.	Crystal structure of UGT74AN3-UDP-DIG	To Be Published	0	0	0	0	
8WNF	38246751	Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in apo form	2023-10-05	2024-02-14	Chen, X.,Guo, Y.,Shi, J.,Wang, Y.,Guo, X.,Wu, G.,Li, S.,Zhang, T.	Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase.	Febs Lett.	2024	598	521	536	
8X6V	38358247	Crystal structure of GlacPETase	2023-11-22	2024-02-14	Qi, X.,Wu, Y.,Zhang, S.T.,Yin, C.F.,Ji, M.,Liu, Y.,Xu, Y.,Zhou, N.Y.	The unique salt bridge network in GlacPETase: a key to its stability.	Appl.Environ.Microbiol.	2024	90	0	0	
8IF1		Complex structure of HLA2402 with recognizing SARS-CoV-2 Y453F epitope NYNYLFRLF	2023-02-16	2024-02-21	Deng, S.S.,Jin, T.C.,Xu, Z.H.,Wang, M.H.	Complex structure of HLA-A*24:02 and SARS-Cov-2 epitope NYNYLFRLF with Y453F mutation	To Be Published	0	0	0	0	
8IDO		Crystal structure of nanobody VHH-T148 with MERS-CoV RBD	2023-02-14	2024-02-28	Tian, L.,Wang, R.,Zhang, L.,Wang, X.	Structures and neutralizing mechanisms of camel nanobodies targeting the receptor-binding domain of MERS-CoV spike glycoprotein	To Be Published	0	0	0	0	
8IGZ		Xcc NAMPT Quadruple mutant	2023-02-21	2024-02-28	Xu, G.L.,Ming, Z.	Structural insights into phytopathogenic bacterial NAD+ biosynthesis via the NAM salvage pathway	To Be Published	0	0	0	0	
8IH6		Crystal structure of decarboxylase-hydratase complex from Pseudomonas species AP-3	2023-02-22	2024-02-28	Shi, Q.L.,Su, D.	Crystal structure of decarboxylase-hydratase complex from Pseudomonas species AP-3	To Be Published	0	0	0	0	
8IH8		anti-sigmaF factor and Anti-sigmaF factor antagonist complex(usfx-RsfB)	2023-02-22	2024-02-28	Chen, Y.J.,Su, D.	High resolutions crystal structure of anti-sigmaF factor and Anti-sigmaF factor antagonist complex(usfx-RsfB)	To Be Published	0	0	0	0	
8IHE		Rv1122(gnd2) in Mycobacterium tuberculosis	2023-02-22	2024-02-28	Chen, Y.J.,Su, D.	Rv1122(gnd2) in Mycobacterium tuberculosis	To Be Published	0	0	0	0	
8IHG		Crystal structure of aminophenol dioxygenase from Pseudomonas species AP-3	2023-02-22	2024-02-28	Shi, Q.L.,Su, D.	Crystal structure of aminophenol dioxygenase from Pseudomonas species AP-3	To Be Published	0	0	0	0	
8IJ6		Crystal structure of alcohol dehydrogenase from Burkholderia gladioli with NADP	2023-02-26	2024-02-28	Han, X.,Mei, Z.L.,Liu, W.D.,Sun, Z.T.,Ma, J.A.	Crystal structure of alcohol dehydrogenase from Burkholderia gladioli with NADP	To Be Published	0	0	0	0	
8IVF	38429999	FABP7 complexed with 25-HC	2023-03-27	2024-02-28	Fang, X.X.,Wei, P.,Zhao, K.,Sheng, Z.C.,Song, B.L.,Yin, L.,Luo, J.	Fatty acid-binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.	J.Cell Biol.	2024	223	0	0	
8IVL	38429999	FABP7 complexed with Cholesterol	2023-03-28	2024-02-28	Fang, X.X.,Wei, P.,Zhao, K.,Sheng, Z.C.,Song, B.L.,Yin, L.,Luo, J.	Fatty acid-binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes.	J.Cell Biol.	2024	223	0	0	
8J1I		Crystal Structure of EphA8/SASH1 Complex	2023-04-12	2024-02-28	Liu, W.,Li, J.,Ding, Y.	Structure of EphA8 and SASH1 complex at 1.60 Angstroms resolution	To Be Published	0	0	0	0	
8JFR		N-terminal domain of AcrIIA15 in complex with palindromic DNA substrate	2023-05-18	2024-02-28	Deng, X.,wang, Y.	N-terminal domain of AcrIIA15 in complex with palindromic DNA substrate	To Be Published	0	0	0	0	
8JFU		AcrIIA15 in complex with palindromic DNA substrate	2023-05-18	2024-02-28	Deng, X.,wang, Y.	AcrIIA15 in complex with palindromic DNA substrate	To Be Published	0	0	0	0	
8Y33	38552148	A near-infrared fluorescent protein of de novo backbone design	2024-01-28	2024-02-28	Hu, X.,Xu, Y.,Yi, J.,Wang, C.,Zhu, Z.,Yue, T.,Zhang, H.,Wang, X.,Wu, F.,Xue, L.,Bai, L.,Liu, H.,Chen, Q.	Using Protein Design and Directed Evolution to Monomerize a Bright Near-Infrared Fluorescent Protein.	Acs Synth Biol	2024	0	0	0	
8YA6		endo-1,3-fucanase Fun168A	2024-02-07	2024-02-28	Chen, G.N.,Chang, Y.G.	Strucutre of endo-1,3-fucanase Fun168A at 1.92 Angstroms resolution.	To Be Published	0	0	0	0	
8YA7		endo-1,3-fucanase Fun168A,complex with fucotetraose	2024-02-07	2024-02-28	Chen, G.N.,Chang, Y.G.	Strucutre of endo-1,3-fucanase Fun168A  complex with fucotetrose at 1.99 Angstroms resolution.	To Be Published	0	0	0	0	
8IHA		Polyketone cyclase Rv2186c in Mycobacterium tuberculosis H37Rv	2023-02-22	2024-03-06	Chen, Y.J.,Su, D.	Crystal structure of polyketone cyclase Rv2186c in Mycobacterium tuberculosis H37Rv	To Be Published	0	0	0	0	
8IK5		Transcription factor LMX1a homeobox domain in complex with Wnt1 promoter	2023-02-28	2024-03-06	Lv, M.Q.,Lin, L.Q.	Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain	Febs J.	2024	0	0	0	
8IKE		Transcription factors LMX1a mutant-R199A homeobox domain complex with Wnt1 promoter	2023-02-28	2024-03-06	Lv, M.Q.,Lin, L.Q.	Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain	Febs J.	2024	0	0	0	
8IL5		Crystal structure of alcohol oxidase PcAOX(M59V/Q60P/R61N)(Phanerochaete chrysosporium)	2023-03-01	2024-03-06	Wu, B.,Wang, Y.	Crystal structure of alcohol oxidase PcAOX(M59V/Q60P/R61N)(Phanerochaete chrysosporium)	To Be Published	0	0	0	0	
8ILT		Crystal structure of Est30	2023-03-04	2024-03-06	Feng, Y.,Luo, Z.	Crystal structure of Est30	To Be Published	0	0	0	0	
8ILW		Transcription factor LMX1a homeobox domain in complex with Pitx3 promoter	2023-03-04	2024-03-06	Lv, M.Q.,Lin, L.Q.	Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain	Febs J.	2024	0	0	0	
8J72	38036331	Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1	2023-04-27	2024-03-06	Shi, F.,Zhang, K.,Cheng, Q.,Che, S.,Zhi, S.,Yu, Z.,Liu, F.,Duan, F.,Wang, Y.,Yang, N.	Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein.	Sci Bull (Beijing)	2024	69	72	81	
8JKK	38324471	Crystal Structure of the dioxygenase CcTet from Coprinopsis cinerea bound to 12bp 5-methylcytosine (5mC) containing duplex DNA	2023-06-01	2024-03-06	Zhang, L.,Mu, Y.,Li, T.,Hu, J.,Lin, H.,Zhang, L.	Molecular basis of an atypical dsDNA 5mC/6mA bifunctional dioxygenase CcTet from Coprinopsis cinerea in catalyzing dsDNA 5mC demethylation.	Nucleic Acids Res.	2024	0	0	0	
8K86	38382670	Crystal structure of NFIL3 in complex with TTATGTAA DNA	2023-07-28	2024-03-06	Chen, S.,Lei, M.,Liu, K.,Min, J.	Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.	J.Biol.Chem.	2024	300	105776	105776	
8K8A	38382670	Crystal structure of NFIL3 in complex with TTACGTAA DNA	2023-07-29	2024-03-06	Chen, S.,Lei, M.,Liu, K.,Min, J.	Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.	J.Biol.Chem.	2024	300	105776	105776	
8K8C	38382670	Crystal structure of C/EBPalpha BZIP domain bound to a high affinity DNA	2023-07-29	2024-03-06	Chen, S.,Lei, M.,Liu, K.,Min, J.	Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.	J.Biol.Chem.	2024	300	105776	105776	
8K8D	38382670	Crystal structure of C/EBPbeta BZIP domain bound to a high affinity DNA	2023-07-29	2024-03-06	Chen, S.,Lei, M.,Liu, K.,Min, J.	Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.	J.Biol.Chem.	2024	300	105776	105776	
8IMU		Dihydroxyacid dehydratase (DHAD) mutant-V497F	2023-03-07	2024-03-13	Zhou, J.,Zang, X.,Tang, Y.,Yan, Y.	Dihydroxyacid dehydratase (DHAD) mutant-V497F	To Be Published	0	0	0	0	
8IN7		Crystal structure of UGT74AN3-UDP	2023-03-08	2024-03-13	Wei, H.,Wei, H.	Crystal structure of UGT74AN3-UDP	To Be Published	0	0	0	0	
8IOK		Crystal structure of AtHPPD-CLJ507 complex	2023-03-11	2024-03-13	Dong, J.,Yang, G.-F.,Lin, H.-Y.	Crystal structure of human HPPD-NTBC complex	To Be Published	0	0	0	0	
8JAH	38367667	Crystal structure of human CLEC12A C-type lectin domain	2023-05-06	2024-03-13	Tang, H.,Xiao, Y.,Qian, L.,Wang, Z.,Lu, M.,Yao, N.,Zhou, T.,Tian, F.,Cao, L.,Zheng, P.,Dong, X.	Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystal.	J.Biol.Chem.	2024	300	105765	105765	
8K2O	38425922	Crystal structure of Fhb7-M10	2023-07-13	2024-03-13	Yang, J.,Liang, K.,Ke, H.,Zhang, Y.,Meng, Q.,Gao, L.,Fan, J.,Li, G.,Zhou, H.,Xiao, J.,Lei, X.	Enzymatic Degradation of Deoxynivalenol with the Engineered Detoxification Enzyme Fhb7.	Jacs Au	2024	4	619	634	
8K2P	38425922	Crystal structure of CtGST-F76A	2023-07-13	2024-03-13	Yang, J.,Liang, K.,Ke, H.,Zhang, Y.,Meng, Q.,Gao, L.,Fan, J.,Li, G.,Zhou, H.,Xiao, J.,Lei, X.	Enzymatic Degradation of Deoxynivalenol with the Engineered Detoxification Enzyme Fhb7.	Jacs Au	2024	4	619	634	
8WQM		Complex structure of AtHPPD with Atovaquone	2023-10-11	2024-03-13	Yang, G.-F.,Lin, H.-Y.,Dong, J.	Complex structure of AtHPPD with Atovaquone	To Be Published	0	0	0	0	
8IRW		Structure of nanobody Nb9 against parathion	2023-03-19	2024-03-20	Li, J.D.	Structure of nanobody Nb9 against parathion	To Be Published	0	0	0	0	
8JE0		A novel amidohydrolase	2023-05-15	2024-03-20	Ma, D.,Feng, R.	A novel amidohydrolase catalyze the degradation of PAM by Klebsiella sp. PCX	To Be Published	0	0	0	0	
8V8J	38477582	PI3Ka H1047R co-crystal structure with inhibitors in two cryptic pockets (compounds 4 and 5).	2023-12-05	2024-03-20	Ketcham, J.M.,Harwood, S.J.,Aranda, R.,Aloiau, A.N.,Bobek, B.M.,Briere, D.M.,Burns, A.C.,Caddell Haatveit, K.,Calinisan, A.,Clarine, J.,Elliott, A.,Engstrom, L.D.,Gunn, R.J.,Ivetac, A.,Jones, B.,Kuehler, J.,Lawson, J.D.,Nguyen, N.,Parker, C.,Pearson, K.E.,Rahbaek, L.,Saechao, B.,Wang, X.,Waters, A.,Waters, L.,Watkins, A.H.,Olson, P.,Smith, C.R.,Christensen, J.G.,Marx, M.A.	Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3K alpha Mutant Protein.	J.Med.Chem.	2024	67	4936	4949	
8IT5		Phosphoglycerate mutase 1 complexed with a compound	2023-03-22	2024-03-27	Zhou, L.,Jiang, L.L.	Phosphoglycerate mutase 1 complexed with a compound	To Be Published	0	0	0	0	
8ITB		Phosphoglycerate mutase 1 complexed with a compound	2023-03-22	2024-03-27	Zhou, L.,Jiang, L.L.	Phosphoglycerate mutase 1 complexed with a compound	To Be Published	0	0	0	0	
8ITQ		Terpene cyclase AriE mutant - D128A	2023-03-22	2024-03-27	Yang, Q.,He, J.Y.,Dong, L.B.	Crystal structure of cis-eunicellane synthase AriE from Amycolatopsis arida	To Be Published	0	0	0	0	
8ITS		Crystal structure of DUF-3268 k-junction	2023-03-22	2024-03-27	Li, M.,Lilley, D.M.J.,Huang, L.	Crystal structure of DUF-3268 k-junction	To Be Published	0	0	0	0	
8ITS		Crystal structure of DUF-3268 k-junction	2023-03-22	2024-03-27	Li, M.,Lilley, D.M.J.,Huang, L.	Crystal structure of DUF-3268 k-junction	To Be Published	0	0	0	0	
8JC5	37775038	Crystal structure of PLEKHM1 RUN domain in complex with GTP-bound Arl8b(Q75L)	2023-05-10	2024-03-27	Qiu, X.,Li, Y.,Wang, Y.,Gong, X.,Wang, Y.,Pan, L.	Mechanistic Insights into the Interactions of Arl8b with the RUN Domains of PLEKHM1 and SKIP.	J.Mol.Biol.	2023	435	168293	168293	
8JJB	38430854	Crystal structure of T2R-TTL-Y61 complex	2023-05-30	2024-03-27	Zhang, C.,Yan, W.,Liu, Y.,Tang, M.,Teng, Y.,Wang, F.,Hu, X.,Zhao, M.,Yang, J.,Li, Y.	Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents.	Eur.J.Med.Chem.	2024	268	116265	116265	
8JJC	38430854	Tubulin-Y62	2023-05-30	2024-03-27	Zhang, C.,Yan, W.,Liu, Y.,Tang, M.,Teng, Y.,Wang, F.,Hu, X.,Zhao, M.,Yang, J.,Li, Y.	Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents.	Eur.J.Med.Chem.	2024	268	116265	116265	
8K14	37992518	X-ray crystal structure of 18a in BRD4(1)	2023-07-10	2024-03-27	Yu, S.,Zhang, Y.,Yang, J.,Xu, H.,Lan, S.,Zhao, B.,Luo, M.,Ma, X.,Zhang, H.,Wang, S.,Shen, H.,Zhang, Y.,Xu, Y.,Li, R.	Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation.	Eur.J.Med.Chem.	2024	263	115924	115924	
8J5U	38548954	Crystal structure of Mycobacterium tuberculosis OppA complexed with an endogenous oligopeptide	2023-04-24	2024-04-03	Yang, X.,Hu, T.,Liang, J.,Xiong, Z.,Lin, Z.,Zhao, Y.,Zhou, X.,Gao, Y.,Sun, S.,Yang, X.,Guddat, L.W.,Yang, H.,Rao, Z.,Zhang, B.	An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality.	Nat.Struct.Mol.Biol.	2024	0	0	0	
8J7Q		The active site mutant of human inorganic pyrophosphatase	2023-04-28	2024-04-03	Hu, F.,Zheng, S.	The active site mutant of human inorganic pyrophosphatase	To Be Published	0	0	0	0	
8X39	38501488	Crystal structure of cellulosomal double-dockerin module of Clo1313_0689 from Clostridium thermocellum	2023-11-12	2024-04-03	Chen, C.,Yang, H.,Dong, S.,You, C.,Morais, S.,Bayer, E.A.,Liu, Y.J.,Xuan, J.,Cui, Q.,Mizrahi, I.,Feng, Y.	A cellulosomal double-dockerin module from Clostridium thermocellum shows distinct structural and cohesin-binding features.	Protein Sci.	2024	33	0	0	
8JWM	38459030	Crystal structure of AKRtyl-NADP-tylosin complex	2023-06-29	2024-04-10	Xiao, Z.,Zha, J.,Yang, X.,Huang, T.,Huang, S.,Liu, Q.,Wang, X.,Zhong, J.,Zheng, J.,Liang, R.,Deng, Z.,Zhang, J.,Lin, S.,Dai, S.	A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.	Nat Commun	2024	15	2128	2128	
8JWN	38459030	Crystal structure of AKRtyl-NADPH complex	2023-06-29	2024-04-10	Xiao, Z.,Zha, J.,Yang, X.,Huang, T.,Huang, S.,Liu, Q.,Wang, X.,Zhong, J.,Zheng, J.,Liang, R.,Deng, Z.,Zhang, J.,Lin, S.,Dai, S.	A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.	Nat Commun	2024	15	2128	2128	
8XKG	38537721	Crystal structure of Acinetobacter baumannii IspD	2023-12-23	2024-04-10	Chen, X.,Zhao, H.,Wang, C.,Hamed, M.,Shang, Q.,Yang, Y.,Diao, X.,Sun, X.,Hu, W.,Jiang, X.,Zhang, Y.,Hirsch, A.K.H.,Wu, D.,Zhuang, J.	Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes.	Int J Antimicrob Agents	2024	0	107160	107160	
8XRT	38527679	The crystal structure of a GH3 enzyme CcBgl3B	2024-01-08	2024-04-10	Hu, C.,Wang, Y.,Wang, W.,Cui, W.,Jia, X.,Mayo, K.H.,Zhou, Y.,Su, J.,Yuan, Y.	A trapped covalent intermediate as a key catalytic element in the hydrolysis of a GH3 beta-glucosidase: An X-ray crystallographic and biochemical study.	Int.J.Biol.Macromol.	2024	265	131131	131131	
8XRU	38527679	The crystal structure of a GH3 enzyme CcBgl3B with glycerol	2024-01-08	2024-04-10	Hu, C.,Wang, Y.,Wang, W.,Cui, W.,Jia, X.,Mayo, K.H.,Zhou, Y.,Su, J.,Yuan, Y.	A trapped covalent intermediate as a key catalytic element in the hydrolysis of a GH3 beta-glucosidase: An X-ray crystallographic and biochemical study.	Int.J.Biol.Macromol.	2024	265	131131	131131	
8XRV	38527679	The crystal structure of a GH3 enzyme CcBgl3B with glucose	2024-01-08	2024-04-10	Hu, C.,Wang, Y.,Wang, W.,Cui, W.,Jia, X.,Mayo, K.H.,Zhou, Y.,Su, J.,Yuan, Y.	A trapped covalent intermediate as a key catalytic element in the hydrolysis of a GH3 beta-glucosidase: An X-ray crystallographic and biochemical study.	Int.J.Biol.Macromol.	2024	265	131131	131131	
8IZU		Crystal structure of the N-terminal domain (residues 1-137) of MPXV A7	2023-04-08	2024-04-17	Ni, X.C.,Lei, J.	Crystal structure of the N-terminal domain (residues 1-137) of MPXV A7	To Be Published	0	0	0	0	
8J29		Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus	2023-04-14	2024-04-17	Ma, Q.,Liu, C.	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus	To Be Published	0	0	0	0	
8J2A		Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+	2023-04-14	2024-04-17	Ma, Q.,Liu, C.	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus	To Be Published	0	0	0	0	
8J2B		Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ and malonate	2023-04-14	2024-04-17	Ma, Q.,Liu, C.	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus	To Be Published	0	0	0	0	
8J2C		Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R	2023-04-14	2024-04-17	Ma, Q.,Liu, C.	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus	To Be Published	0	0	0	0	
8J2D		Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+	2023-04-14	2024-04-17	Ma, Q.,Liu, C.	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus	To Be Published	0	0	0	0	
8J2E		Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ and malonate	2023-04-14	2024-04-17	Ma, Q.,Liu, C.	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus	To Be Published	0	0	0	0	
8J2N		Exopolysaccharide phosphotransferase CpsY in Mycobacterium tuberculosis	2023-04-14	2024-04-17	Liu, D.F.	Exopolysaccharide phosphotransferase CpsY in Mycobacterium tuberculosis	To Be Published	0	0	0	0	
8PMI	38600265	Structure of Nal1 indica cultivar IR64, construct 36-458 in presence of peptide from FZP protein	2023-06-28	2024-04-17	Huang, L.Y.,Liu, N.N.,Chen, W.F.,Ai, X.,Li, H.H.,Zhang, Z.L.,Hou, X.M.,Fosse, P.,Mauffret, O.,Lei, D.S.,Rety, S.,Xi, X.G.	The catalytic triad of rice NARROW LEAF1 involves H234.	Nat.Plants	2024	0	0	0	
8PML	38600265	Structure of Nal1 protein , SPIKE allele from japonica rice, construct 46-458	2023-06-29	2024-04-17	Huang, L.Y.,Liu, N.N.,Chen, W.F.,Ai, X.,Li, H.H.,Zhang, Z.L.,Hou, X.M.,Fosse, P.,Mauffret, O.,Lei, D.S.,Rety, S.,Xi, X.G.	The catalytic triad of rice NARROW LEAF1 involves H234.	Nat.Plants	2024	0	0	0	
8PMM	38600265	Structure of Nal1 protein, allele SPIKE from japonica rice, construct 31-458	2023-06-29	2024-04-17	Huang, L.Y.,Liu, N.N.,Chen, W.F.,Ai, X.,Li, H.H.,Zhang, Z.L.,Hou, X.M.,Fosse, P.,Mauffret, O.,Lei, D.S.,Rety, S.,Xi, X.G.	The catalytic triad of rice NARROW LEAF1 involves H234.	Nat.Plants	2024	0	0	0	
8YZN		Crystal structural analysis of PaL	2024-04-07	2024-04-17	Xu, G.,Wu, J.	Crystal structural analysis of PaL	To Be Published	0	0	0	0	
7YLD		Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis	2022-07-26	2024-04-24	Hu, M.,Du, Y.,Sun, R.,Hao, Q.	Two monobodies recognizing the conserved epitopes of SARS-CoV-2 N antigen applicable to the broad COVID-19 diagnosis	To Be Published	0	0	0	0	
8H83		Crystal structure of a IsPETase variant V22 from Ideonella sakaiensis	2022-10-21	2024-04-24	Wei, H.L.,Gao, S.F.,Li, Q.,Han, X.,Gao, J.,Liu, W.D.	Crystal structure of a IsPETase variant V22 from Ideonella sakaiensis	to be published	0	0	0	0	
8IF0		NmeHNH-AcrIIC1 complex	2023-02-16	2024-04-24	Zhu, Y.L.	Inhibition Mechanism of CRISPR-Cas9 by Anti-CRISPR Protein AcrIIC1	To Be Published	0	0	0	0	
8J3X		Crystal structure of CBM6E from Saccharophagus degradans	2023-04-18	2024-04-24	He, C.,Li, F.	Structural insights into CBM6E from Saccharophagus degradans	To Be Published	0	0	0	0