PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 2QUL 17936787 Crystal structure of D-tagatose 3-epimerase from Pseudomonas cichorii at 1.79 A resolution 2007-08-06 2007-12-25 Yoshida, H.,Yamada, M.,Nishitani, T.,Takada, G.,Izumori, K.,Kamitori, S. Crystal structures of D-tagatose 3-epimerase from Pseudomonas cichorii and its complexes with D-tagatose and D-fructose J.Mol.Biol. 2007 374 443 453 2QUN 17936787 Crystal Structure of D-tagatose 3-epimerase from Pseudomonas cichorii in Complex with D-fructose 2007-08-06 2007-12-25 Yoshida, H.,Yamada, M.,Nishitani, T.,Takada, G.,Izumori, K.,Kamitori, S. Crystal structures of D-tagatose 3-epimerase from Pseudomonas cichorii and its complexes with D-tagatose and D-fructose J.Mol.Biol. 2007 374 443 453 2Z8D 18332142 The galacto-N-biose-/lacto-N-biose I-binding protein (GL-BP) of the ABC transporter from Bifidobacterium longum in complex with lacto-N-biose 2007-09-05 2008-03-18 Suzuki, R.,Wada, J.,Katayama, T.,Fushinobu, S.,Wakagi, T.,Shoun, H.,Sugimoto, H.,Tanaka, A.,Kumagai, H.,Ashida, H.,Kitaoka, M.,Yamamoto, K. Structural and thermodynamic analyses of solute-binding Protein from Bifidobacterium longum specific for core 1 disaccharide and lacto-N-biose I. J.Biol.Chem. 2008 283 13165 13173 2Z8E 18332142 The galacto-N-biose-/lacto-N-biose I-binding protein (GL-BP) of the ABC transporter from Bifidobacterium longum in complex with galacto-N-biose 2007-09-05 2008-03-18 Suzuki, R.,Wada, J.,Katayama, T.,Fushinobu, S.,Wakagi, T.,Shoun, H.,Sugimoto, H.,Tanaka, A.,Kumagai, H.,Ashida, H.,Kitaoka, M.,Yamamoto, K. Structural and thermodynamic analyses of solute-binding Protein from Bifidobacterium longum specific for core 1 disaccharide and lacto-N-biose I. J.Biol.Chem. 2008 283 13165 13173 2Z8F 18332142 The galacto-N-biose-/lacto-N-biose I-binding protein (GL-BP) of the ABC transporter from Bifidobacterium longum in complex with lacto-N-tetraose 2007-09-05 2008-03-18 Suzuki, R.,Wada, J.,Katayama, T.,Fushinobu, S.,Wakagi, T.,Shoun, H.,Sugimoto, H.,Tanaka, A.,Kumagai, H.,Ashida, H.,Kitaoka, M.,Yamamoto, K. Structural and thermodynamic analyses of solute-binding Protein from Bifidobacterium longum specific for core 1 disaccharide and lacto-N-biose I. J.Biol.Chem. 2008 283 13165 13173 2PVP 18320587 Crystal structure of D-Alanine-D-Alanine Ligase from Helicobacter pylori 2007-05-10 2008-04-01 Wu, D.,Zhang, L.,Kong, Y.,Du, J.,Chen, S.,Chen, J.,Ding, J.,Jiang, H.,Shen, X. Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori. Proteins 2008 72 1148 1160 2YVE 20691702 Crystal structure of the methylene blue-bound form of the multi-drug binding transcriptional repressor CgmR 2007-04-12 2008-04-15 Itou, H.,Watanabe, N.,Yao, M.,Shirakihara, Y.,Tanaka, I. Crystal Structures of the Multidrug Binding Repressor Corynebacteriumglutamicum CgmR in Complex with Inducers and with an Operator J.Mol.Biol. 2010 403 174 184 2ZCZ 18287284 Crystal structures and thermostability of mutant TRAP3 A7 (ENGINEERED TRAP) 2007-11-15 2008-04-29 Watanabe, M.,Mishima, Y.,Yamashita, I.,Park, S.Y.,Tame, J.R.,Heddle, J.G. Intersubunit linker length as a modifier of protein stability: crystal structures and thermostability of mutant TRAP. Protein Sci. 2008 17 518 526 2Z0Q 23192023 Crystal structure of DH-PH domain of RhoGEF3(Xpln) 2007-05-07 2008-05-13 Murayama, K.,Kato-Murayama, M.,Akasaka, R.,Terada, T.,Yokoyama, S.,Shirouzu, M. Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Acta Crystallogr.,Sect.F 2012 68 1455 1459 3BM4 18462755 Crystal Structure of Human ADP-ribose Pyrophosphatase NUDT5 In complex with magnesium and AMPcpr 2007-12-12 2008-05-20 Zha, M.,Guo, Q.,Zhang, Y.,Yu, B.,Ou, Y.,Zhong, C.,Ding, J. Molecular Mechanism of ADP-Ribose Hydrolysis By Human NUDT5 From Structural and Kinetic Studies J.Mol.Biol. 2008 379 568 578 3CTZ 18515364 Structure of human cytosolic X-prolyl aminopeptidase 2008-04-15 2008-05-27 Li, X.,Lou, Z.,Li, X.,Zhou, W.,Ma, M.,Cao, Y.,Geng, Y.,Bartlam, M.,Zhang, X.C.,Rao, Z. Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit J.Biol.Chem. 2008 283 22858 22866 3DEH 18768468 Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 2008-06-10 2008-09-02 Du, J.-Q.,Wu, J.,Zhang, H.-J.,Zhang, Y.-H.,Qiu, B.-Y.,Wu, F.,Chen, Y.-H.,Li, J.-Y.,Nan, F.-J.,Ding, J.-P.,Li, J. Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 2008 283 30205 30215 3DEI 18768468 Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 2008-06-10 2008-09-02 Du, J.-Q.,Wu, J.,Zhang, H.-J.,Zhang, Y.-H.,Qiu, B.-Y.,Wu, F.,Chen, Y.-H.,Li, J.-Y.,Nan, F.-J.,Ding, J.-P.,Li, J. Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 2008 283 30205 30215 3DEJ 18768468 Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 2008-06-10 2008-09-02 Du, J.-Q.,Wu, J.,Zhang, H.-J.,Zhang, Y.-H.,Qiu, B.-Y.,Wu, F.,Chen, Y.-H.,Li, J.-Y.,Nan, F.-J.,Ding, J.-P.,Li, J. Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 2008 283 30205 30215 3DEK 18768468 Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 2008-06-10 2008-09-02 Du, J.-Q.,Wu, J.,Zhang, H.-J.,Zhang, Y.-H.,Qiu, B.-Y.,Wu, F.,Chen, Y.-H.,Li, J.-Y.,Nan, F.-J.,Ding, J.-P.,Li, J. Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 2008 283 30205 30215 2ZND 18940611 Crystal structure of Ca2+-free form of des3-20ALG-2 2008-04-22 2008-09-09 Suzuki, H.,Kawasaki, M.,Inuzuka, T.,Okumura, M.,Kakiuchi, T.,Shibata, H.,Wakatsuki, S.,Maki, M. Structural Basis for Ca(2+)-Dependent Formation of ALG-2/Alix Peptide Complex: Ca(2+)/EF3-Driven Arginine Switch Mechanism Structure 2008 16 1562 1573 2ZOT 19020352 Crystal structure of human F-spondin reeler domain (fragment 1) 2008-06-07 2008-10-14 Nagae, M.,Nishikawa, K.,Yasui, N.,Yamasaki, M.,Nogi, T.,Takagi, J. Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop Acta Crystallogr.,Sect.D 2008 64 1138 1145 3E9G 18984594 Crystal structure long-form (residue1-124) of Eaf3 chromo domain 2008-08-22 2008-11-04 Sun, B.,Hong, J.,Zhang, P.,Dong, X.,Shen, X.,Lin, D.,Ding, J. Molecular Basis of the Interaction of Saccharomyces cerevisiae Eaf3 Chromo Domain with Methylated H3K36 J.Biol.Chem. 2008 283 36504 36512 3BLE 18498255 Crystal structure of the catalytic domain of LiCMS in complexed with malonate 2007-12-11 2008-11-11 Ma, J.,Zhang, P.,Zhang, Z.,Zha, M.,Xu, H.,Zhao, G.,Ding, J. Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans Biochem.J. 2008 415 45 56 2ZUT 19124470 Crystal structure of Galacto-N-biose/Lacto-N-biose I phosphorylase in complex with GalNAc 2008-10-28 2008-12-30 Hidaka, M.,Nishimoto, M.,Kitaoka, M.,Wakagi, T.,Shoun, H.,Fushinobu, S. The crystal structure of galacto-N-biose/lacto-N-biose I phosphorylase: A large deformation of a tim barrel scaffold J.Biol.Chem. 2009 284 7273 7283 2ZK7 19089950 Structure of a C-terminal deletion mutant of Thermoplasma acidophilum aldohexose dehydrogenase (AldT) 2008-03-12 2009-01-13 Nishioka, T.,Yasutake, Y.,Nishiya, Y.,Tamura, N.,Tamura, T. C-terminal tail derived from the neighboring subunit is critical for the activity of Thermoplasma acidophilum D-aldohexose dehydrogenase Proteins 2009 74 801 807 2ZRV 19158086 Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with reduced FMN. 2008-09-01 2009-01-20 Unno, H.,Yamashita, S.,Ikeda, Y.,Sekiguchi, S.Y.,Yoshida, N.,Yoshimura, T.,Kusunoki, M.,Nakayama, T.,Nishino, T.,Hemmi, H. New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase. J.Biol.Chem. 2009 284 9160 9167 2ZRW 19158086 Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with FMN and IPP. 2008-09-01 2009-01-20 Unno, H.,Yamashita, S.,Ikeda, Y.,Sekiguchi, S.Y.,Yoshida, N.,Yoshimura, T.,Kusunoki, M.,Nakayama, T.,Nishino, T.,Hemmi, H. New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase. J.Biol.Chem. 2009 284 9160 9167 2ZRX 19158086 Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with FMN and DMAPP. 2008-09-01 2009-01-20 Unno, H.,Yamashita, S.,Ikeda, Y.,Sekiguchi, S.Y.,Yoshida, N.,Yoshimura, T.,Kusunoki, M.,Nakayama, T.,Nishino, T.,Hemmi, H. New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase. J.Biol.Chem. 2009 284 9160 9167 2ZRY 19158086 Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with reduced FMN and IPP. 2008-09-01 2009-01-20 Unno, H.,Yamashita, S.,Ikeda, Y.,Sekiguchi, S.Y.,Yoshida, N.,Yoshimura, T.,Kusunoki, M.,Nakayama, T.,Nishino, T.,Hemmi, H. New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase. J.Biol.Chem. 2009 284 9160 9167 2ZRZ 19158086 Crystal structure of Sulfolobus shibatae isopentenyl diphosphate isomerase in complex with reduced FMN and DMAPP 2008-09-01 2009-01-20 Unno, H.,Yamashita, S.,Ikeda, Y.,Sekiguchi, S.Y.,Yoshida, N.,Yoshimura, T.,Kusunoki, M.,Nakayama, T.,Nishino, T.,Hemmi, H. New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase. J.Biol.Chem. 2009 284 9160 9167 2ZY4 19368885 dodecameric L-aspartate beta-decarboxylase 2009-01-13 2009-01-27 Chen, H.-J.,Ko, T.-P.,Lee, C.-Y.,Wang, N.-C.,Wang, A.H.-J. Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase Structure 2009 17 517 529 2ZY5 19368885 R487A mutant of L-aspartate beta-decarboxylase 2009-01-13 2009-01-27 Chen, H.-J.,Ko, T.-P.,Lee, C.-Y.,Wang, N.-C.,Wang, A.H.-J. Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric l-Aspartate beta-Decarboxylase Structure 2009 17 517 529 2ZP8 19164760 The Nature of the TRAP:Anti-TRAP complex 2008-07-08 2009-02-03 Watanabe, M.,Heddle, J.G.,Kikuchi, K.,Unzai, S.,Akashi, S.,Park, S.Y.,Tame, J.R. The nature of the TRAP-Anti-TRAP complex. Proc.Natl.Acad.Sci.USA 2009 106 2176 2181 3FAK 19116143 Structural and Functional Analysis of a Hormone-Sensitive Lipase like EstE5 from a Metagenome Library 2008-11-17 2009-02-10 Nam, K.H.,Kim, M.-Y.,Kim, S.-J.,Priyadarshi, A.,Lee, W.H.,Hwang, K.Y. Structural and functional analysis of a novel EstE5 belonging to the subfamily of hormone-sensitive lipase Biochem.Biophys.Res.Commun. 2009 379 553 556 2ZW0 19269963 Crystal structure of a Streptococcal protein G B1 mutant 2008-11-26 2009-03-03 Watanabe, H.,Matsumaru, H.,Ooishi, A.,Feng, Y.,Odahara, T.,Suto, K.,Honda, S. Optimizing pH response of affinity between protein G and IgG Fc: how electrostatic modulations affect protein-protein interactions. J.Biol.Chem. 2009 284 12373 12383 2ZNY 19004003 Crystal structure of the FFRP 2008-05-02 2009-03-17 Yamada, M.,Ishijima, S.A.,Suzuki, M. Interactions between the archaeal transcription repressor FL11 and its coregulators lysine and arginine. Proteins 2009 74 520 525 2ZNZ 19004003 Crystal structure of FFRP 2008-05-02 2009-03-17 Yamada, M.,Ishijima, S.A.,Suzuki, M. Interactions between the archaeal transcription repressor FL11 and its coregulators lysine and arginine. Proteins 2009 74 520 525 2ZVN 19303852 NEMO CoZi domain incomplex with diubiquitin in P212121 space group 2008-11-12 2009-03-24 Rahighi, S.,Ikeda, F.,Kawasaki, M.,Akutsu, M.,Suzuki, N.,Kato, R.,Kensche, T.,Uejima, T.,Bloor, S.,Komander, D.,Randow, F.,Wakatsuki, S.,Dikic, I. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation Cell(Cambridge,Mass.) 2009 136 1098 1109 2ZVO 19303852 NEMO CoZi domain in complex with diubiquitin in C2 space group 2008-11-12 2009-03-24 Rahighi, S.,Ikeda, F.,Kawasaki, M.,Akutsu, M.,Suzuki, N.,Kato, R.,Kensche, T.,Uejima, T.,Bloor, S.,Komander, D.,Randow, F.,Wakatsuki, S.,Dikic, I. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation Cell(Cambridge,Mass.) 2009 136 1098 1109 3F89 19303852 NEMO CoZi domain 2008-11-11 2009-03-24 Rahighi, S.,Ikeda, F.,Kawasaki, M.,Akutsu, M.,Suzuki, N.,Kato, R.,Kensche, T.,Uejima, T.,Bloor, S.,Komander, D.,Randow, F.,Wakatsuki, S.,Dikic, I. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation Cell(Cambridge,Mass.) 2009 136 1098 1109 3FLM 19338755 Crystal structure of menD from E.coli 2008-12-19 2009-03-24 Priyadarshi, A.,Saleem, Y.,Nam, K.H.,Kim, K.S.,Park, S.Y.,Kim, E.E.,Hwang, K.Y. Structural insights of the MenD from Escherichia coli reveal ThDP affinity. Biochem.Biophys.Res.Commun. 2009 380 797 801 2ZKL Crystal Structure of capsular polysaccharide assembling protein CapF from staphylococcus aureus 2008-03-25 2009-03-31 Miyafusa, T.,Tanaka, Y.,Kuroda, M.,Yao, M.,Watanabe, N.,Ohta, T.,Tanaka, I.,Tsumoto, K. Crystal structure of capsular polysaccharide assembling protein from Staphylococcus aureus to be published 0 0 0 0 2ZKL Crystal Structure of capsular polysaccharide assembling protein CapF from staphylococcus aureus 2008-03-25 2009-03-31 Miyafusa, T.,Tanaka, Y.,Kuroda, M.,Yao, M.,Watanabe, N.,Ohta, T.,Tanaka, I.,Tsumoto, K. Crystal structure of capsular polysaccharide assembling protein from Staphylococcus aureus to be published 0 0 0 0 3EOB 19258452 Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II 2008-09-26 2009-04-14 Li, S.,Wang, H.,Peng, B.,Zhang, M.,Zhang, D.,Hou, S.,Guo, Y.,Ding, J. Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance. Proc.Natl.Acad.Sci.USA 2009 106 4349 4354 2ZNT 21893069 Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, dysiherbaine 2008-05-01 2009-05-05 Unno, M.,Shinohara, M.,Takayama, K.,Tanaka, H.,Teruya, K.,Doh-Ura, K.,Sakai, R.,Sasaki, M.,Ikeda-Saito, M. Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol. 2011 413 667 683 2ZNU 21893069 Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, neodysiherbaine A 2008-05-01 2009-05-05 Unno, M.,Shinohara, M.,Takayama, K.,Tanaka, H.,Teruya, K.,Doh-Ura, K.,Sakai, R.,Sasaki, M.,Ikeda-Saito, M. Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol. 2011 413 667 683 2ZXI 19446527 Structure of Aquifex aeolicus GidA in the form II crystal 2008-12-24 2009-05-19 Osawa, T.,Ito, K.,Inanaga, H.,Nureki, O.,Tomita, K.,Numata, T. Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon Structure 2009 17 713 724 2ZXU 19435325 Crystal structure of tRNA modification enzyme MiaA in the complex with tRNA(Phe) and DMASPP 2009-01-07 2009-05-26 Chimnaronk, S.,Forouhar, F.,Sakai, J.,Yao, M.,Tron, C.M.,Atta, M.,Fontecave, M.,Hunt, J.F.,Tanaka, I. Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon Biochemistry 2009 48 5057 5065 2ZTT 19461581 Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus 2008-10-08 2009-06-09 Sugiyama, K.,Obayashi, E.,Kawaguchi, A.,Suzuki, Y.,Tame, J.R.H.,Nagata, K.,Park, S.-Y. Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase Embo J. 2009 28 1803 1811 3A1G 19461581 High-Resolution Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus 2009-04-02 2009-06-09 Sugiyama, K.,Obayashi, E.,Kawaguchi, A.,Suzuki, Y.,Tame, J.R.H.,Nagata, K.,Park, S.-Y. Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase Embo J. 2009 28 1803 1811 2ZOW Crystal Structure of H2O2 treated Cu,Zn-SOD 2008-06-11 2009-06-30 Ito, S.,Ishii, T.,Sakai, H.,Uchida, K. Crystal structures of H2O2-treated Cu,Zn-superoxide dismutase To be Published 0 0 0 0 2ZTG 19423669 Crystal structure of Archaeoglobus fulgidus alanyl-tRNA synthetase lacking the C-terminal dimerization domain in complex with Ala-SA 2008-10-01 2009-06-30 Naganuma, M.,Sekine, S.,Fukunaga, R.,Yokoyama, S. Unique protein architecture of alanyl-tRNA synthetase for aminoacylation, editing, and dimerization. Proc.Natl.Acad.Sci.USA 2009 106 8489 8494 3A21 19608743 Crystal Structure of Streptomyces avermitilis beta-L-Arabinopyranosidase 2009-04-27 2009-07-14 Ichinose, H.,Fujimoto, Z.,Honda, M.,Harazono, K.,Nishimoto, Y.,Uzura, A.,Kaneko, S. A beta-l-Arabinopyranosidase from Streptomyces avermitilis is a novel member of glycoside hydrolase family 27. J.Biol.Chem. 2009 284 25097 25106 3E5N Crystal structure of D-alanine-D-alanine ligase from Xanthomonas oryzae pv. oryzae KACC10331 2008-08-14 2009-08-18 Doan, T.N.T.,Kim, J.K.,Kim, H.S.,Ahn, Y.J.,Kim, J.G.,Lee, B.M.,Kang, L.W. Crystal structure of D-alanine-D-alanine ligase from Xanthomonas oryzae pv. oryzae KACC10331 To be published 0 0 0 0 3E6G Crystal structure of XometC, a cystathionine c-lyase-like protein from Xanthomonas oryzae pv.oryzae 2008-08-15 2009-08-18 Ngo, H.P.T.,Kim, J.K.,Kim, H.S.,Jung, J.H.,Ahn, Y.J.,Kim, J.G.,Lee, B.M.,Kang, H.W.,Kang, L.W. Crystal structure of XometC, a cystathionine c-lyase-like protein from Xanthomonas oryzae pv.oryzae To be published 0 0 0 0 2ZTL 19122202 Closed conformation of D-3-hydroxybutyrate dehydrogenase complexed with NAD+ and L-3-hydroxybutyrate 2008-10-07 2009-08-25 Nakashima, K.,Ito, K.,Nakajima, Y.,Yamazawa, R.,Miyakawa, S.,Yoshimoto, T. Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem. 2009 145 467 479 2ZTM 19122202 T190S mutant of D-3-hydroxybutyrate dehydrogenase 2008-10-07 2009-08-25 Nakashima, K.,Ito, K.,Nakajima, Y.,Yamazawa, R.,Miyakawa, S.,Yoshimoto, T. Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem. 2009 145 467 479 2ZTN 19620712 Hepatitis E virus ORF2 (Genotype 3) 2008-10-08 2009-08-25 Yamashita, T.,Mori, Y.,Miyazaki, N.,Cheng, R.H.,Yoshimura, M.,Unno, H.,Shima, R.,Moriishi, K.,Tsukihara, T.,Li, T.C.,Takeda, N.,Miyamura, T.,Matsuura, Y. Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure Proc.Natl.Acad.Sci.USA 2009 106 12986 12991 2ZTU 19122202 T190A mutant of D-3-hydroxybutyrate dehydrogenase complexed with NAD+ 2008-10-09 2009-08-25 Nakashima, K.,Ito, K.,Nakajima, Y.,Yamazawa, R.,Miyakawa, S.,Yoshimoto, T. Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem. 2009 145 467 479 2ZTV 19122202 The binary complex of D-3-hydroxybutyrate dehydrogenase with NAD+ 2008-10-09 2009-08-25 Nakashima, K.,Ito, K.,Nakajima, Y.,Yamazawa, R.,Miyakawa, S.,Yoshimoto, T. Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem. 2009 145 467 479 2ZXG 19622865 Aminopeptidase N complexed with the aminophosphinic inhibitor of PL250, a transition state analogue 2008-12-24 2009-08-25 Fournie-Zaluski, M.C.,Poras, H.,Roques, B.P.,Nakajima, Y.,Ito, K.,Yoshimoto, T. Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250 Acta Crystallogr.,Sect.D 2009 65 814 822 3GCE 19616558 Ferredoxin of carbazole 1,9a-dioxygenase from Nocardioides aromaticivorans IC177 2009-02-22 2009-09-15 Inoue, K.,Ashikawa, Y.,Umeda, T.,Abo, M.,Katsuki, J.,Usami, Y.,Noguchi, H.,Fujimoto, Z.,Terada, T.,Yamane, H.,Nojiri, H. Specific Interactions between the ferredoxin and terminal oxygenase components of a class IIB Rieske nonheme iron oxygenase, carbazole 1,9a-dioxygenase. J.Mol.Biol. 2009 392 436 451 3A44 19769985 Crystal structure of HypA in the dimeric form 2009-06-30 2009-10-06 Watanabe, S.,Arai, T.,Matsumi, R.,Atomi, H.,Imanaka, T.,Miki, K. Crystal structure of HypA, a nickel-binding metallochaperone for [NiFe] hydrogenase maturation. J.Mol.Biol. 2009 394 448 459 3A5T 19797082 Crystal structure of MafG-DNA complex 2009-08-11 2009-10-13 Kurokawa, H.,Motohashi, H.,Sueno, S.,Kimura, M.,Takagawa, H.,Kanno, Y.,Yamamoto, M.,Tanaka, T. Structural Basis of Alternative DNA Recognition by Maf Transcription Factors Mol.Cell.Biol. 2009 29 6232 6244 3HW3 19587036 The crystal structure of avian influenza virus PA_N in complex with UMP 2009-06-17 2009-10-13 Zhao, C.,Lou, Z.,Guo, Y.,Ma, M.,Chen, Y.,Liang, S.,Zhang, L.,Chen, S.,Li, X.,Liu, Y.,Bartlam, M.,Rao, Z. Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center J.Virol. 2009 83 9024 9030 3HW5 19587036 crystal structure of avian influenza virus PA_N in complex with AMP 2009-06-17 2009-10-13 Zhao, C.,Lou, Z.,Guo, Y.,Ma, M.,Chen, Y.,Liang, S.,Zhang, L.,Chen, S.,Li, X.,Liu, Y.,Bartlam, M.,Rao, Z. 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Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen Faseb J. 2010 24 3861 3868 3AQD Unliganded TRAP 2010-10-29 2010-12-29 Malay, A.A.D.,Watanabe, M.,Heddle, J.G.,Tame, J.R.H. Allostery in TRAP To be Published 0 0 0 0 3L9F The Crystal Structure of smu.1604c from Streptococcus mutans UA159 2010-01-05 2011-01-05 Su, X.-D.,Liu, X. The Crystal Structure of smu.1604c from Streptococcus mutans UA159 TO BE PUBLISHED 0 0 0 0 3L9T The Crystal Structure of smu.31 from Streptococcus mutans UA159 2010-01-05 2011-01-05 Su, X.-D.,Cao, Q.,Liu, X. The Crystal Structure of smu.31 from Streptococcus mutans UA159 TO BE PUBLISHED 0 0 0 0 3N2N 20585457 The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain 2010-05-18 2011-01-05 Fu, S.,Tong, X.,Cai, C.,Zhao, Y.,Wu, Y.,Li, Y.,Xu, J.,Zhang, X.C.,Xu, L.,Chen, W.,Rao, Z. The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin. Plos One 2010 5 0 0 3ALZ 21217702 Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I) 2010-08-11 2011-01-12 Hashiguchi, T.,Ose, T.,Kubota, M.,Maita, N.,Kamishikiryo, J.,Maenaka, K.,Yanagi, Y. Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM Nat.Struct.Mol.Biol. 2011 18 135 141 3LD2 The Crystal Structure of smu.2055 from Streptococcus mutans UA159 2010-01-12 2011-01-12 Su, X.-D.,Zhan, X.R.,Gao, X.Z.,Liu, X. The Crystal Structure of smu.2055 from Streptococcus mutans UA159 TO BE PUBLISHED 0 0 0 0 3ALU 21247895 Crystal structure of CEL-IV complexed with Raffinose 2010-08-07 2011-01-19 Hatakeyama, T.,Kamiya, T.,Kusunoki, M.,Nakamura-Tsuruta, S.,Hirabayashi, J.,Goda, S.,Unno, H. Galactose recognition by a tetrameric C-type lectin, CEL-IV, containing the EPN carbohydrate recognition motif J.Biol.Chem. 2011 286 10305 10315 3AE1 Crystal structure of porcine heart mitochondrial complex II bound with N-Phenyl-2-(trifluoromethyl)-benzamide 2010-02-04 2011-02-09 Harada, S.,Sasaki, T.,Shindo, M.,Kido, Y.,Inaoka, D.K.,Omori, J.,Osanai, A.,Sakamoto, K.,Mao, J.,Matsuoka, S.,Inoue, M.,Honma, T.,Tanaka, A.,Kita, K. Crystal structure of porcine heart mitochondrial complex II bound with N-Phenyl-2-(trifluoromethyl)-benzamide to be published 0 0 0 0 3AE4 Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamide 2010-02-04 2011-02-09 Harada, S.,Sasaki, T.,Shindo, M.,Kido, Y.,Inaoka, D.K.,Omori, J.,Osanai, A.,Sakamoto, K.,Mao, J.,Matsuoka, S.,Inoue, M.,Honma, T.,Tanaka, A.,Kita, K. Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamide To be Published 0 0 0 0 3AE6 Crystal structure of porcine heart mitochondrial complex II bound with N-(3-Isopropoxy-phenyl)-phthalamicacid 2010-02-04 2011-02-09 Harada, S.,Sasaki, T.,Shindo, M.,Kido, Y.,Inaoka, D.K.,Omori, J.,Osanai, A.,Sakamoto, K.,Mao, J.,Matsuoka, S.,Inoue, M.,Honma, T.,Tanaka, A.,Kita, K. Crystal structure of porcine heart mitochondrial complex II bound with N-(3-Isopropoxy-phenyl)-phthalamicacid To be Published 0 0 0 0 3AE7 26198225 Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-(3-isopropoxy-phenyl)-benzamide 2010-02-04 2011-02-09 Inaoka, D.K.,Shiba, T.,Sato, D.,Balogun, E.O.,Sasaki, T.,Nagahama, M.,Oda, M.,Matsuoka, S.,Ohmori, J.,Honma, T.,Inoue, M.,Kita, K.,Harada, S. Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria Int J Mol Sci 2015 16 15287 15308 3AEB Crystal structure of porcine heart mitochondrial complex II bound with N-(3-Phenoxy-phenyl)-2-trifluoromethyl-benzamide 2010-02-04 2011-02-09 Harada, S.,Sasaki, T.,Shindo, M.,Kido, Y.,Inaoka, D.K.,Omori, J.,Osanai, A.,Sakamoto, K.,Mao, J.,Matsuoka, S.,Inoue, M.,Honma, T.,Tanaka, A.,Kita, K. Crystal structure of porcine heart mitochondrial complex II bound with N-(3-Phenoxy-phenyl)-2-trifluoromethyl-benzamide To be Published 0 0 0 0 3AEC Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-(1-methylethyl)-benzamid 2010-02-04 2011-02-09 Harada, S.,Sasaki, T.,Shindo, M.,Kido, Y.,Inaoka, D.K.,Omori, J.,Osanai, A.,Sakamoto, K.,Mao, J.,Matsuoka, S.,Inoue, M.,Honma, T.,Tanaka, A.,Kita, K. Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-(1-methylethyl)-benzamid To be Published 0 0 0 0 3AED Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-phenyl-benzamide 2010-02-04 2011-02-09 Harada, S.,Sasaki, T.,Shindo, M.,Kido, Y.,Inaoka, D.K.,Omori, J.,Osanai, A.,Sakamoto, K.,Mao, J.,Matsuoka, S.,Inoue, M.,Honma, T.,Tanaka, A.,Kita, K. Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-phenyl-benzamide To be Published 0 0 0 0 3AEM Reaction intermediate structure of Entamoeba histolytica methionine gamma-lyase 1 containing Michaelis complex and methionine imine-pyridoxamine-5'-phosphate 2010-02-10 2011-02-09 Karaki, T.,Sato, D.,Shimizu, A.,Nozaki, T.,Harada, S. Crystal structure of Entamoeba histolytica methionine gamma-lyase 1 To be published 0 0 0 0 3AEN Reaction intermediate structure of Entamoeba histolytica methionine gamma-lyase 1 containing Michaelis complex and alpha-amino-alpha, beta-butenoic acid-pyridoxal-5'-phosphate 2010-02-10 2011-02-09 Karaki, T.,Sato, D.,Shimizu, A.,Nozaki, T.,Harada, S. Crystal structure of Entamoeba histolytica methionine gamma-lyase 1 To be Published 0 0 0 0 3AQK 21300291 Structure of bacterial protein (apo form I) 2010-11-09 2011-02-09 Toh, Y.,Takeshita, D.,Nagaike, T.,Numata, T.,Tomita, K. Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases Structure 2011 19 232 243 3AQL 21300291 Structure of bacterial protein (apo form II) 2010-11-09 2011-02-09 Toh, Y.,Takeshita, D.,Nagaike, T.,Numata, T.,Tomita, K. Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases Structure 2011 19 232 243 3AQM 21300291 Structure of bacterial protein (form II) 2010-11-09 2011-02-09 Toh, Y.,Takeshita, D.,Nagaike, T.,Numata, T.,Tomita, K. Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases Structure 2011 19 232 243 3AQN 21300291 Complex structure of bacterial protein (apo form II) 2010-11-09 2011-02-09 Toh, Y.,Takeshita, D.,Nagaike, T.,Numata, T.,Tomita, K. Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases Structure 2011 19 232 243 3APW 21349832 Crystal structure of the A variant of human alpha1-acid glycoprotein and disopyramide complex 2010-10-21 2011-02-23 Nishi, K.,Ono, T.,Nakamura, T.,Fukunaga, N.,Izumi, M.,Watanabe, H.,Suenaga, A.,Maruyama, T.,Yamagata, Y.,Curry, S.,Otagiri, M. Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms. J. Biol. Chem. 2011 286 14427 14434 3MOO 20806922 Crystal structure of the HmuO, heme oxygenase from Corynebacterium diphtheriae, in complex with azide-bound verdoheme 2010-04-22 2011-03-09 Lai, W.,Chen, H.,Matsui, T.,Omori, K.,Unno, M.,Ikeda-Saito, M.,Shaik, S. Enzymatic ring-opening mechanism of verdoheme by the heme oxygenase: a combined X-ray crystallography and QM/MM study. J.Am.Chem.Soc. 2010 132 12960 12970 3OYY 21365687 Structure of Pseudomonas aeruginosa elongation factor P 2010-09-24 2011-03-09 Choi, S.,Choe, J. Crystal structure of elongation factor P from Pseudomonas aeruginosa at 1.75 angstrom resolution. Proteins 2011 79 1688 1693 3MWM 21383173 Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur 2010-05-06 2011-03-16 Shin, J.-H.,Jung, H.J.,An, Y.J.,Cho, Y.-B.,Cha, S.-S.,Roe, J.-H. Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur Proc.Natl.Acad.Sci.USA 2011 108 5045 5050 3ALF 21240541 Crystal Structure of Class V Chitinase from Nicotiana tobaccum 2010-08-03 2011-03-23 Ohnuma, T.,Numata, T.,Osawa, T.,Mizuhara, M.,Varum, K.M.,Fukamizo, T. Crystal structure and mode of action of a class V chitinase from Nicotiana tabacum Plant Mol.Biol. 2011 75 291 304 3ALF 21240541 Crystal Structure of Class V Chitinase from Nicotiana tobaccum 2010-08-03 2011-03-23 Ohnuma, T.,Numata, T.,Osawa, T.,Mizuhara, M.,Varum, K.M.,Fukamizo, T. Crystal structure and mode of action of a class V chitinase from Nicotiana tabacum Plant Mol.Biol. 2011 75 291 304 3ALG 21240541 Crystal Structure of Class V Chitinase (E115Q mutant) from Nicotiana tobaccum in complex with NAG4 2010-08-03 2011-03-23 Ohnuma, T.,Numata, T.,Osawa, T.,Mizuhara, M.,Varum, K.M.,Fukamizo, T. Crystal structure and mode of action of a class V chitinase from Nicotiana tabacum Plant Mol.Biol. 2011 75 291 304 3AGR Crystal structure of nucleoside triphosphate hydrolases from Neospora caninum 2010-04-06 2011-04-06 Matoba, K.,Shiba, T.,Takeuchi, T.,Sibley, L.D.,Asai, T.,Harada, S. Crystal structure of nucleoside triphosphate hydrolases from Neospora caninum To be Published 0 0 0 0 3R97 Crystal structure of malonyl-CoA:acyl carrier protein transacylase (FabD), Xoo0880, from Xanthomonas oryzae pv. oryzae KACC10331 2011-03-25 2011-04-13 Natarajan, S.,Jung, J.W.,Kang, L.W. Crystal structure of malonyl-CoA:acyl carrier protein transacylase (FabD), Xoo0880, from Xanthomonas oryzae pv. oryzae KACC10331 To be Published 0 0 0 0 3QXL 21494904 Crystal structure of the CDC25 Domain from Ral-specific Guanine-nucleotide Exchange Factor RalGPS1a 2011-03-02 2011-05-11 Peng, W.,Xu, J.,Guan, X.,Sun, Y.,Zhang, X.C.,Li, X.,Rao, Z. Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a. Protein Cell 2011 2 308 319 3MVE 21623357 Crystal structure of a novel pyruvate decarboxylase 2010-05-04 2011-05-18 Lee, K.J.,Jeong, C.S.,An, Y.J.,Lee, H.J.,Park, S.J.,Seok, Y.J.,Kim, P.,Lee, J.H.,Lee, K.H.,Cha, S.S. FrsA functions as a cofactor-independent decarboxylase to control metabolic flux. Nat.Chem.Biol. 2011 7 434 436 3Q4N 21604308 Crystal structure of hypothetical protein MJ0754 from Methanococcus jannaschii DSM 2661 2010-12-24 2011-05-18 Lee, E.H.,Kim, H.S.,Kim, H.Y.,Jeon, Y.H.,Hwang, K.Y. Structural insights into the metal binding properties of hypothetical protein MJ0754 from Methanococcus jannaschii. Proteins 2011 79 2358 2363 3OUR 21623357 Crystal structure of complex between EIIA and a novel pyruvate decarboxylase 2010-09-15 2011-06-01 Lee, K.J.,Jeong, C.S.,An, Y.J.,Lee, H.J.,Park, S.J.,Seok, Y.J.,Kim, P.,Lee, J.H.,Lee, K.H.,Cha, S.S. FrsA functions as a cofactor-independent decarboxylase to control metabolic flux Nat.Chem.Biol. 2011 7 434 436 3N6L 21203964 The crystal structure of RNA-dependent RNA polymerase of EV71 virus 2010-05-26 2011-06-15 Wu, Y.,Lou, Z.,Miao, Y.,Yu, Y.,Dong, H.,Peng, W.,Bartlam, M.,Li, X.,Rao, Z. Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell 2010 1 491 500 3N6M 21203964 Crystal structure of EV71 RdRp in complex with GTP 2010-05-26 2011-06-15 Wu, Y.,Lou, Z.,Miao, Y.,Yu, Y.,Dong, H.,Peng, W.,Bartlam, M.,Li, X.,Rao, Z. Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell 2010 1 491 500 3N6N 21203964 crystal structure of EV71 RdRp in complex with Br-UTP 2010-05-26 2011-06-15 Wu, Y.,Lou, Z.,Miao, Y.,Yu, Y.,Dong, H.,Peng, W.,Bartlam, M.,Li, X.,Rao, Z. Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell 2010 1 491 500 3ND5 21912874 Crystal structure of phosphopantetheine adenylyltransferase (PPAT) from Enterococcus faecalis 2010-06-07 2011-06-22 Yoon, H.J.,Kang, J.Y.,Mikami, B.,Lee, H.H.,Suh, S.W. Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine Mol.Cells 2011 32 431 435 3ND6 21912874 Crystal structure of phosphopantetheine adenylyltransferase (PPAT) in complex with ATP from Enterococcus faecalis 2010-06-07 2011-06-22 Yoon, H.J.,Kang, J.Y.,Mikami, B.,Lee, H.H.,Suh, S.W. Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine Mol.Cells 2011 32 431 435 3ND7 21912874 Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine 2010-06-07 2011-06-22 Yoon, H.J.,Kang, J.Y.,Mikami, B.,Lee, H.H.,Suh, S.W. Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine Mol.Cells 2011 32 431 435 3AX5 21591667 Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions. 2011-03-29 2011-07-06 Saitoh, T.,Igura, M.,Miyazaki, Y.,Ose, T.,Maita, N.,Kohda, D. Crystallographic snapshots of tom20-mitochondrial presequence interactions with disulfide-stabilized peptides. Biochemistry 2011 50 5487 5496 3NMZ 21788986 Crystal structure of APC complexed with Asef 2010-06-23 2011-07-06 Zhang, Z.,Chen, L.,Gao, L.,Lin, K.,Zhu, L.,Lu, Y.,Shi, X.,Gao, Y.,Zhou, J.,Xu, P.,Zhang, J.,Wu, G. Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res. 2012 22 372 386 3AQU 21390509 Crystal structure of a class V chitinase from Arabidopsis thaliana 2010-11-19 2011-07-20 Ohnuma, T.,Numata, T.,Osawa, T.,Mizuhara, M.,Lampela, O.,Juffer, A.H.,Skriver, K.,Fukamizo, T. A class V chitinase from Arabidopsis thaliana: gene responses, enzymatic properties, and crystallographic analysis Planta 2011 234 123 137 3OFT 21154803 Crystal Structure of Cytochrome P450 CYP101C1 2010-08-16 2011-07-20 Ma, M.,Bell, S.G.,Yang, W.,Hao, Y.,Rees, N.H.,Bartlam, M.,Zhou, W.,Wong, L.L.,Rao, Z. Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444. Chembiochem 2011 12 88 99 3PVD 21811409 Crystal structure of P domain dimer of Norovirus VA207 complexed with 3'-sialyl-Lewis x tetrasaccharide 2010-12-06 2011-08-03 Chen, Y.,Tan, M.,Xia, M.,Hao, N.,Zhang, X.C.,Huang, P.,Jiang, X.,Li, X.,Rao, Z. Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens Plos Pathog. 2011 7 0 0 3S65 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R2 quaternary structures 2011-05-25 2011-08-03 Shibayama, N.,Sugiyama, K.,Park, S.Y. Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Glu->Lys) in the R and R2 quaternary structure To be Published 0 0 0 0 3S66 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R quaternary structures 2011-05-25 2011-08-03 Shibayama, N.,Park, S.Y.,Sugiyama, K. Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Glu->Lys) in the R and R2 quaternary structure To be Published 0 0 0 0 3AU8 22355528 Crystal structure of the ternary complex of an isomerase 2011-02-01 2011-08-10 Umeda, T.,Tanaka, N.,Kusakabe, Y.,Nakanishi, M.,Kitade, Y.,Nakamura, K.T. Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum Sci Rep 2011 1 9 9 3B0Q Human PPAR gamma ligand binding domain in complex with MCC555 2011-06-13 2011-08-10 Tomioka, D.,Hashimoto, H.,Sato, M.,Shimizu, T. Crystal structure of human PPAR gamma in complex with MCC555 To be Published 0 0 0 0 3B0R Human PPAR gamma ligand binding dmain complexed with GW9662 in a covalent bonded form 2011-06-13 2011-08-10 Shimizu, T. Human PPAR gamma ligand binding dmain complexed with GW9662 in a covalent bonded form To be published 0 0 0 0 3RMD 21781974 Crystal Structure of a replicative DNA polymerase bound to DNA containing Thymine Glycol 2011-04-20 2011-08-10 Aller, P.,Duclos, S.,Wallace, S.S.,Doublie, S. A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex. J.Mol.Biol. 2011 412 22 34 3TC1 Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori 2011-08-08 2011-08-31 Zhang, J.Y.,Zhang, X.L.,Li, D.F.,Zou, Q.M.,Wang, D.C. Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori To be Published 0 0 0 0 3TC1 Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori 2011-08-08 2011-08-31 Zhang, J.Y.,Zhang, X.L.,Li, D.F.,Zou, Q.M.,Wang, D.C. Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori To be Published 0 0 0 0 3SFD 21822798 crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and pentachlorophenol 2011-06-13 2011-09-07 Zhou, Q.,Zhai, Y.,Lou, J.,Liu, M.,Pang, X.,Sun, F. Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature. 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Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance. J.Struct.Biol. 2011 175 300 310 3AX8 21539305 Crystal structure of the human vitamin D receptor ligand binding domain complexed with 15alpha-methoxy-1alpha,25-dihydroxyvitamin D3 2011-03-30 2011-10-05 Shindo, K.,Kumagai, G.,Takano, M.,Sawada, D.,Saito, N.,Saito, H.,Kakuda, S.,Takagi, K.,Ochiai, E.,Horie, K.,Takimoto-Kamimura, M.,Ishizuka, S.,Takenouchi, K.,Kittaka, A. New C15-substituted active vitamin D3 Org.Lett. 2011 13 2852 2855 3TKQ 21916849 Crystal structure of full-length human peroxiredoxin 4 with mixed conformation 2011-08-28 2011-10-05 Wang, X.,Wang, L.,Wang, X.,Sun, F.,Wang, C.-C. Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J. 2011 0 0 0 3TKR 21916849 Crystal structure of full-length human peroxiredoxin 4 with T118E mutation 2011-08-28 2011-10-05 Wang, X.,Wang, L.,Wang, X.,Sun, F.,Wang, C.-C. Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J. 2011 0 0 0 3ASU 21349860 Crystal structure of serine dehydrogenase from Escherichia coli 2010-12-21 2011-10-12 Yamazawa, R.,Nakajima, Y.,Mushiake, K.,Yoshimoto, T.,Ito, K. Crystal structure of serine dehydrogenase from Escherichia coli: important role of the C-terminal region for closed-complex formation. J.Biochem. 2011 149 701 712 3AMT 22002223 Crystal structure of the TiaS-tRNA(Ile2)-ATP complex 2010-08-23 2011-10-19 Osawa, T.,Kimura, S.,Terasaka, N.,Inanaga, H.,Suzuki, T.,Numata, T. 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Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction. Nat Commun 2013 4 1572 1572 3B1T 21882827 Crystal structure of human peptidylarginine deiminase 4 in complex with o-Cl-amidine 2011-07-13 2011-10-26 Causey, C.P.,Jones, J.E.,Slack, J.L.,Kamei, D.,Jones Jr, L.E.,Subramanian, V.,Knuckley, B.,Ebrahimi, P.,Chumanevich, A.A.,Luo, Y.,Hashimoto, H.,Sato, M.,Hofseth, L.J.,Thompson, P.R. The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors J.Med.Chem. 2011 54 6919 6935 3B1U 21882827 Crystal structure of human peptidylarginine deiminase 4 in complex with o-F-amidine 2011-07-13 2011-10-26 Causey, C.P.,Jones, J.E.,Slack, J.L.,Kamei, D.,Jones Jr, L.E.,Subramanian, V.,Knuckley, B.,Ebrahimi, P.,Chumanevich, A.A.,Luo, Y.,Hashimoto, H.,Sato, M.,Hofseth, L.J.,Thompson, P.R. 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RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNA Nucleic Acids Res. 2012 40 11115 11125 4H10 23229515 Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic Helix-Loop-Helix domains with E-box DNA 2012-09-10 2012-12-26 Wang, Z.,Wu, Y.,Li, L.,Su, X.D. Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA. Cell Res. 2013 23 213 224 3VYB 23316048 Crystal structure of methyl CpG binding domain of MBD4 in complex with the 5mCG/hmCG sequence 2012-09-22 2013-01-16 Otani, J.,Arita, K.,Kato, T.,Kinoshita, M.,Kimura, H.,Suetake, I.,Tajima, S.,Ariyoshi, M.,Shirakawa, M. 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Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol. 2013 87 6829 6839 4J4V 23576501 Pentameric SFTSVN with suramin 2013-02-07 2013-05-22 Jiao, L.,Ouyang, S.,Liang, M.,Niu, F.,Shaw, N.,Wu, W.,Ding, W.,Jin, C.,Peng, Y.,Zhu, Y.,Zhang, F.,Wang, T.,Li, C.,Zuo, X.,Luan, C.H.,Li, D.,Liu, Z.J. Structure of severe Fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential J.Virol. 2013 87 6829 6839 4K64 23641058 Structure of an avian influenza H5 hemagglutinin from the influenza virus complexed with human receptor analog LSTc 2013-04-15 2013-05-22 Zhang, W.,Shi, Y.,Lu, X.,Shu, Y.,Qi, J.,Gao, G.F. An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. 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Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR Proc.Natl.Acad.Sci.USA 2013 110 0 0 4JR4 23828196 Crystal structure of Mtb DsbA (Oxidized) 2013-03-21 2013-07-17 Wang, L.,Li, J.,Wang, X.,Liu, W.,Zhang, X.C.,Li, X.,Rao, Z. Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. Protein Cell 2013 4 628 640 4G4V Crystal structure of peptidoglycan-associated lipoprotein from Acinetobacter baumannii 2012-07-16 2013-07-24 Lee, W.C.,Park, J.S.,Song, J.H.,Kim, S.I.,Lee, J.C.,Cheong, J.,Kim, H.Y. Enantiomer-dependent amino acid binding affinity of OmpA-like domains from Acinetobacter baumannii peptidoglycan-associated lipoprotein and OmpA To be Published 0 0 0 0 4G4X Crystal structure of peptidoglycan-associated lipoprotein from Acinetobacter baumannii 2012-07-16 2013-07-24 Lee, W.C.,Park, J.S.,Song, J.H.,Kim, S.I.,Lee, J.C.,Cheong, J.,Kim, H.Y. Enantiomer-dependent amino acid binding affinity of OmpA-like domains from Acinetobacter baumannii peptidoglycan-associated lipoprotein and OmpA To be Published 0 0 0 0 4G4Y Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii 2012-07-16 2013-07-24 Lee, W.C.,Park, J.S.,Song, J.H.,Kim, S.I.,Lee, J.C.,Cheong, J.,Kim, H.Y. Enantiomer-dependent amino acid binding affinity of OmpA-like domains from Acinetobacter baumannii peptidoglycan-associated lipoprotein and OmpA To be Published 0 0 0 0 4G4Z Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii 2012-07-16 2013-07-24 Lee, W.C.,Park, J.S.,Song, J.H.,Kim, S.I.,Lee, J.C.,Cheong, J.,Kim, H.Y. Enantiomer-dependent amino acid binding affinity of OmpA-like domains from Acinetobacter baumannii peptidoglycan-associated lipoprotein and OmpA To be Published 0 0 0 0 4G88 Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii 2012-07-22 2013-07-24 Lee, W.C.,Park, J.S.,Song, J.H.,Kim, S.I.,Lee, J.C.,Cheong, J.,Kim, H.Y. Enantiomer-dependent amino acid binding affinity of OmpA-like domains from Acinetobacter baumannii peptidoglycan-associated lipoprotein and OmpA to be published 0 0 0 0 3VW4 25538245 Crystal structure of the DNA-binding domain of ColE2-P9 Rep in complex with the replication origin 2012-07-31 2013-07-31 Itou, H.,Yagura, M.,Shirakihara, Y.,Itoh, T. Structural Basis for Replication Origin Unwinding by An Initiator-Primase of Plasmid ColE2-P9: Duplex DNA Unwinding by A Single Protein J.Biol.Chem. 2015 290 3601 3611 3W0Q 23747390 Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (N203A), ternary complex with AMP-PNP and hygromycin B 2012-11-02 2013-08-07 Iino, D.,Takakura, Y.,Fukano, K.,Sasaki, Y.,Hoshino, T.,Ohsawa, K.,Nakamura, A.,Yajima, S. Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant. J.Struct.Biol. 2013 183 76 85 3W0R 23747390 Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (N202A), ternary complex with AMP-PNP and hygromycin B 2012-11-02 2013-08-07 Iino, D.,Takakura, Y.,Fukano, K.,Sasaki, Y.,Hoshino, T.,Ohsawa, K.,Nakamura, A.,Yajima, S. Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant. J.Struct.Biol. 2013 183 76 85 3W6X 23818613 Yeast N-acetyltransferase Mpr1 in complex with CHOP 2013-02-25 2013-08-07 Nasuno, R.,Hirano, Y.,Itoh, T.,Hakoshima, T.,Hibi, T.,Takagi, H. Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism Proc.Natl.Acad.Sci.USA 2013 110 11821 11826 4JGH 23897481 Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5 2013-03-01 2013-08-07 Kim, Y.K.,Kwak, M.J.,Ku, B.,Suh, H.Y.,Joo, K.,Lee, J.,Jung, J.U.,Oh, B.H. Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. Acta Crystallogr.,Sect.D 2013 69 1587 1597 4K7E 23884367 Crystal structure of Junin virus nucleoprotein 2013-04-17 2013-08-07 Zhang, Y.J.,Li, L.,Liu, X.,Dong, S.S.,Wang, W.M.,Huo, T.,Guo, Y.,Rao, Z.H.,Yang, C. Crystal structure of Junin virus nucleoprotein J.Gen.Virol. 2013 94 2175 2183 3WD5 23943614 Crystal structure of TNFalpha in complex with Adalimumab Fab fragment 2013-06-06 2013-08-14 Hu, S.,Liang, S.Y.,Guo, H.,Zhang, D.,Li, H.,Wang, X.,Yang, W.,Qian, W.,Hou, S.,Wang, H.,Guo, Y.J.,Lou, Z.Y. Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor alpha-associated diseases from a molecular view J.Biol.Chem. 2013 288 27059 27067 3W81 23959878 Human alpha-l-iduronidase 2013-03-11 2013-08-21 Maita, N.,Tsukimura, T.,Taniguchi, T.,Saito, S.,Ohno, K.,Taniguchi, H.,Sakuraba, H. Human alpha-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module Proc.Natl.Acad.Sci.USA 2013 110 14628 14633 3W82 23959878 Human alpha-L-iduronidase in complex with iduronic acid 2013-03-11 2013-08-21 Maita, N.,Tsukimura, T.,Taniguchi, T.,Saito, S.,Ohno, K.,Taniguchi, H.,Sakuraba, H. Human alpha-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module Proc.Natl.Acad.Sci.USA 2013 110 14628 14633 3WD8 TypeIII polyketide synthases 2013-06-10 2013-09-04 Mori, T.,Shimokawa, Y.,Matsui, T.,Kinjo, K.,Kato, R.,Noguchi, H.,Sugio, S.,Morita, H.,Abe, I. Cloning, characterization, and crystal structure analysis of novel type III polyketide synthases from Citrus microcarpa To be Published 0 0 0 0 3WEV 23908359 Crystal structure of the Schiff base intermediate of L-Lys epsilon-oxidase from Marinomonas mediterranea with L-Lys 2013-07-12 2013-09-04 Okazaki, S.,Nakano, S.,Matsui, D.,Akaji, S.,Inagaki, K.,Asano, Y. X-Ray crystallographic evidence for the presence of the cysteine tryptophylquinone cofactor in L-lysine {varepsilon}-oxidase from Marinomonas mediterranea J.Biochem. 2013 154 233 236 3WD2 24043811 Serratia marcescens Chitinase B complexed with azide inhibitor 2013-06-06 2013-09-18 Hirose, T.,Maita, N.,Gouda, H.,Koseki, J.,Yamamoto, T.,Sugawara, A.,Nakano, H.,Hirono, S.,Shiomi, K.,Watanabe, T.,Taniguchi, H.,Sharpless, K.B.,Omura, S.,Sunazuka, T. Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor Proc.Natl.Acad.Sci.USA 2013 110 15892 15897 3VY5 N33Q mutant of FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F) 2012-09-21 2013-09-25 Takagi, R.,Nakanishi, T.,Kitamura, M. Crystal structure of N33Q mutant of FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F) To be Published 0 0 0 0 3VY6 24790092 Crystal structure of human pancreatic secretory protein ZG16p with laminaribiose 2012-09-21 2013-09-25 Kanagawa, M.,Liu, Y.,Hanashima, S.,Ikeda, A.,Chai, W.,Nakano, Y.,Kojima-Aikawa, K.,Feizi, T.,Yamaguchi, Y. Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin J.Biol.Chem. 2014 289 16954 16965 3VYA W32Y mutant of FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F) 2012-09-22 2013-09-25 Takagi, R.,Nakanishi, T.,Kitamura, M. Crystal structure of W32Y mutant of FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F) To be Published 0 0 0 0 3VYJ 24108122 Crystal structure of C-type lectin domain of murine dendritic cell inhibitory receptor 2 (apo form) 2012-09-26 2013-10-02 Nagae, M.,Yamanaka, K.,Hanashima, S.,Ikeda, A.,Morita-Matsumoto, K.,Satoh, T.,Matsumoto, N.,Yamamoto, K.,Yamaguchi, Y. Recognition of Bisecting N-Acetylglucosamine: STRUCTURAL BASIS FOR ASYMMETRIC INTERACTION WITH THE MOUSE LECTIN DENDRITIC CELL INHIBITORY RECEPTOR 2 J.Biol.Chem. 2013 288 33598 33610 3WA5 24100309 Crystal Structure of type VI peptidoglycan muramidase effector Tse3 in complex with its cognate immunity protein Tsi3 2013-04-26 2013-10-02 Wang, T.,Ding, J.,Zhang, Y.,Wang, D.C.,Liu, W. Complex structure of type VI peptidoglycan muramidase effector and a cognate immunity protein. Acta Crystallogr.,Sect.D 2013 69 1889 1900 4J20 24052268 X-ray structure of the cytochrome c-554 from chlorobaculum tepidum 2013-02-04 2013-10-02 Yu, L.J.,Unno, M.,Kimura, Y.,Yanagimoto, K.,Oh-oka, H.,Wang-otomo, Z.Y. Structure analysis and characterization of the cytochrome c-554 from thermophilic green sulfur photosynthetic bacterium Chlorobaculum tepidum Photosynth.Res. 2013 118 249 258 4H4Q Crystal Structure of Ferredoxin reductase, BphA4 E175Q/Q177K (reduced form) 2012-09-18 2013-10-09 Nishizawa, A.,Harada, A.,Senda, M.,Tachihara, Y.,Muramatsu, D.,Kishigami, S.,Mori, S.,Sugiyama, K.,Senda, T.,Kimura, S. Random Mutagenesis with the Project Assessment for Complete Conversion of Co-Factor Specificity of a Ferredoxin Reductase BphA4 To be Published 0 0 0 0 4K88 24100331 Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form) 2013-04-18 2013-10-09 Son, J.,Lee, E.H.,Park, M.,Kim, J.H.,Kim, J.,Kim, S.,Jeon, Y.H.,Hwang, K.Y. Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Crystallogr.,Sect.D 2013 69 2136 2145 3VWN Crystal structure of 6-aminohexanoate-dimer hydrolase G181D/R187G/H266N/D370Y mutant 2012-08-30 2013-10-16 Negoro, S.,Kawashima, Y.,Shibata, N.,Shigeta, Y.,Kobayashi, T.,Nishiguchi, H.,Matsui, T.,Baba, T.,Lee, Y.,Kamiya, K.,Kato, D.,Takeo, M.,Higuchi, Y. Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction To be Published 0 0 0 0 3W2V 23583914 Crystal structure of the Cmr2dHD-Cmr3 subcomplex bound to 3'-AMP 2012-12-06 2013-10-16 Osawa, T.,Inanaga, H.,Numata, T. Crystal Structure of the Cmr2-Cmr3 Subcomplex in the CRISPR-Cas RNA Silencing Effector Complex. J.Mol.Biol. 2013 425 3811 3823 3W2W 23583914 Crystal structure of the Cmr2dHD-Cmr3 subcomplex bound to ATP 2012-12-06 2013-10-16 Osawa, T.,Inanaga, H.,Numata, T. Crystal Structure of the Cmr2-Cmr3 Subcomplex in the CRISPR-Cas RNA Silencing Effector Complex. J.Mol.Biol. 2013 425 3811 3823 3WBD 24100042 Crystal structure of anti-polysialic acid antibody single chain Fv fragment (mAb735) complexed with octasialic acid 2013-05-14 2013-10-16 Nagae, M.,Ikeda, A.,Hane, M.,Hanashima, S.,Kitajima, K.,Sato, C.,Yamaguchi, Y. Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid: insight into the binding preference for polysialic acid. J.Biol.Chem. 2013 288 33784 33796 4J0L 23871710 Crystal Structure of a Family GH19 Chitinase (W72A/E67Q mutant) from rye seeds in complex with two (GlcNAc)4 molecules 2013-01-31 2013-10-16 Ohnuma, T.,Umemoto, N.,Kondo, K.,Numata, T.,Fukamizo, T. Complete subsite mapping of a ""loopful"" GH19 chitinase from rye seeds based on its crystal structure Febs Lett. 2013 587 2691 2697 3W9W 24121327 Crystal structure of DING protein 2013-04-17 2013-10-30 Gai, Z.Q.,Nakamura, A.,Tanaka, Y.,Hirano, N.,Tanaka, I.,Yao, M. Crystal structure analysis, overexpression and refolding behaviour of a DING protein with single mutation. J.SYNCHROTRON RADIAT. 2013 20 854 858 3WAR 24121351 Crystal structure of human CK2a 2013-05-07 2013-10-30 Kinoshita, T.,Nakaniwa, T.,Sekiguchi, Y.,Sogabe, Y.,Sakurai, A.,Nakamura, S.,Nakanishi, I. Crystal structure of human CK2 alpha at 1.06 angstrom resolution J.SYNCHROTRON RADIAT. 2013 20 974 979 3WC3 24121333 Crystal structure of endo-1,4-beta-glucanase from Eisenia fetida 2013-05-24 2013-10-30 Arimori, T.,Ito, A.,Nakazawa, M.,Ueda, M.,Tamada, T. Crystal structure of endo-1,4-beta-glucanase from Eisenia fetida J.SYNCHROTRON RADIAT. 2013 20 884 889 4HZZ 23824808 Crystal structure of influenza neuraminidase N3-H274Y complexed with oseltamivir 2012-11-16 2013-11-06 Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F. Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance. J.Virol. 2013 87 10016 10024 4L51 24047255 Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition 2013-06-10 2013-11-06 Ha, J.H.,Eo, Y.,Grishaev, A.,Guo, M.,Smith, J.A.,Sintim, H.O.,Kim, E.H.,Cheong, H.K.,Bentley, W.E.,Ryu, K.S. Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J.Am.Chem.Soc. 2013 135 15526 15535 4I00 23824808 Crystal structure of influenza A neuraminidase N3-H274Y complexed with zanamivir 2012-11-16 2013-11-13 Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F. Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance. J.Virol. 2013 87 10016 10024 3W1R Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-045a 2012-11-20 2013-11-20 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-045a To be Published 0 0 0 0 4MZ7 24217394 Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase 2013-09-29 2013-11-20 Zhu, C.,Gao, W.,Zhao, K.,Qin, X.,Zhang, Y.,Peng, X.,Zhang, L.,Dong, Y.,Zhang, W.,Li, P.,Wei, W.,Gong, Y.,Yu, X.F. Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase Nat Commun 2013 4 2722 2722 3W1T Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-095 2012-11-21 2013-11-27 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-095 To be Published 0 0 0 0 3W1X Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-121 2012-11-22 2013-11-27 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-121. To be Published 0 0 0 0 3W22 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125 2012-11-26 2013-11-27 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125 To be Published 0 0 0 0 3W23 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-131 2012-11-26 2013-11-27 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-131 To be Published 0 0 0 0 3W2J Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-135 2012-11-28 2013-12-04 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-135 To be Published 0 0 0 0 3W2U Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-193 2012-12-05 2013-12-11 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Matsuoka, S.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-193 To be Published 0 0 0 0 3WBM 24307170 Crystal Structure of protein-RNA complex 2013-05-20 2013-12-11 Guo, L.,Ding, J.,Guo, R.,Hou, Y.,Wang, D.C.,Huang, L. Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea. J.Biol.Chem. 2014 289 1478 1490 4LKL 24223211 Crystal structure of Plk1 Polo-box domain in complex with PL-55 2013-07-08 2013-12-11 Murugan, R.N.,Ahn, M.,Lee, W.C.,Kim, H.Y.,Song, J.H.,Cheong, C.,Hwang, E.,Seo, J.H.,Shin, S.Y.,Choi, S.H.,Park, J.E.,Bang, J.K. Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1 Plos One 2013 8 0 0 3WKL 24389025 The periplasmic PDZ tandem fragment of the RseP homologue from Aquifex aeolicus 2013-10-28 2013-12-18 Hizukuri, Y.,Oda, T.,Tabata, S.,Tamura-kawakami, K.,Oi, R.,Sato, M.,Takagi, J.,Akiyama, Y.,Nogi, T. A Structure-Based Model of Substrate Discrimination by a Noncanonical PDZ Tandem in the Intramembrane-Cleaving Protease RseP Structure 2013 22 326 336 3WKM 24389025 The periplasmic PDZ tandem fragment of the RseP homologue from Aquifex aeolicus in complex with the Fab fragment 2013-10-28 2013-12-18 Hizukuri, Y.,Oda, T.,Tabata, S.,Tamura-kawakami, K.,Oi, R.,Sato, M.,Takagi, J.,Akiyama, Y.,Nogi, T. A Structure-Based Model of Substrate Discrimination by a Noncanonical PDZ Tandem in the Intramembrane-Cleaving Protease RseP Structure 2013 22 326 336 3WAL 24290141 Crystal structure of human LC3A_2-121 2013-05-06 2013-12-25 Suzuki, H.,Tabata, K.,Morita, E.,Kawasaki, M.,Kato, R.,Dobson, R.C.,Yoshimori, T.,Wakatsuki, S. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. Structure 2014 22 47 58 3WAN 24290141 Crystal structure of Atg13 LIR-fused human LC3A_2-121 2013-05-06 2013-12-25 Suzuki, H.,Tabata, K.,Morita, E.,Kawasaki, M.,Kato, R.,Dobson, R.C.,Yoshimori, T.,Wakatsuki, S. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. Structure 2014 22 47 58 3WAO 24290141 Crystal structure of Atg13 LIR-fused human LC3B_2-119 2013-05-06 2013-12-25 Suzuki, H.,Tabata, K.,Morita, E.,Kawasaki, M.,Kato, R.,Dobson, R.C.,Yoshimori, T.,Wakatsuki, S. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. Structure 2014 22 47 58 3WAP 24290141 Crystal structure of Atg13 LIR-fused human LC3C_8-125 2013-05-06 2013-12-25 Suzuki, H.,Tabata, K.,Morita, E.,Kawasaki, M.,Kato, R.,Dobson, R.C.,Yoshimori, T.,Wakatsuki, S. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. Structure 2014 22 47 58 3WBP 24425442 Crystal structure of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) lectin (crystal form-1) 2013-05-20 2013-12-25 Nagae, M.,Ikeda, A.,Kitago, Y.,Matsumoto, N.,Yamamoto, K.,Yamaguchi, Y. Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer. Proteins 2014 82 1512 1518 3WBQ 24425442 Crystal structure of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) lectin (crystal form-2) 2013-05-20 2013-12-25 Nagae, M.,Ikeda, A.,Kitago, Y.,Matsumoto, N.,Yamamoto, K.,Yamaguchi, Y. Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer. Proteins 2014 82 1512 1518 3WBR 24425442 Crystal structure of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) lectin (crystal form-3) 2013-05-20 2013-12-25 Nagae, M.,Ikeda, A.,Kitago, Y.,Matsumoto, N.,Yamamoto, K.,Yamaguchi, Y. Crystal structures of carbohydrate recognition domain of blood dendritic cell antigen-2 (BDCA2) reveal a common domain-swapped dimer. Proteins 2014 82 1512 1518 3WGN 24347164 STAPHYLOCOCCUS AUREUS FTSZ bound with GTP-gamma-S 2013-08-06 2013-12-25 Matsui, T.,Han, X.,Yu, J.,Yao, M.,Tanaka, I. Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop J.Biol.Chem. 2014 289 3501 3509 3WFO 24389024 tRNA processing enzyme (apo form 1) 2013-07-23 2014-01-01 Yamashita, S.,Takeshita, D.,Tomita, K. Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure 2014 22 315 325 3WFP 24389024 tRNA processing enzyme (apo form 2) 2013-07-23 2014-01-01 Yamashita, S.,Takeshita, D.,Tomita, K. Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure 2014 22 315 325 3WFQ 24389024 tRNA processing enzyme complex 1 2013-07-23 2014-01-01 Yamashita, S.,Takeshita, D.,Tomita, K. Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure 2014 22 315 325 3WFS 24389024 tRNA processing enzyme complex 3 2013-07-23 2014-01-01 Yamashita, S.,Takeshita, D.,Tomita, K. Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase Structure 2014 22 315 325 4LJK 24369431 Structural insights into the unique single-stranded DNA binding mode of DNA processing protein A from Helicobacter pylori 2013-07-05 2014-01-01 Wang, W.,Ding, J.,Zhang, Y.,Hu, Y.,Wang, D.C. Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res. 2014 42 3478 3491 4LJR 24369431 Structural insights into the unique single-stranded DNA binding mode of DNA processing protein A from Helicobacter pylori 2013-07-05 2014-01-01 Wang, W.,Ding, J.,Zhang, Y.,Hu, Y.,Wang, D.C. Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res. 2014 42 3478 3491 3WE1 24373879 Crystal structure of Dengue 4 Envelope protein domain III (ED3) 2013-06-27 2014-01-22 Elahi, M.,Islam, M.M.,Noguchi, K.,Yohda, M.,Toh, H.,Kuroda, Y. Computational prediction and experimental characterization of a ""size switch type repacking"" during the evolution of dengue envelope protein domain III (ED3). Biochim.Biophys.Acta 2014 1844 585 592 3W5F Crystal structure of tomato beta-galactosidase 4 2013-01-29 2014-01-29 Eda, M.,Tada, T. Crystal structure of tomato beta-galactosidase 4 To be Published 0 0 0 0 3WEG 24531458 Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and magnesium ion 2013-07-07 2014-02-12 Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Shih, M.F.,Ko, T.P.,Wang, A.H.J. Structural insights into the catalytic mechanism of human squalene synthase. Acta Crystallogr.,Sect.D 2014 70 231 241 4BFM 24531485 The crystal structure of mouse PK38 2013-03-21 2014-02-12 Cho, Y.S.,Yoo, J.,Park, S.,Cho, H.S. The Structures of the Kinase Domain and Uba Domain of Mpk38 Suggest the Activation Mechanism for Kinase Activity. Acta Crystallogr.,Sect.D 2014 70 514 0 3W94 24481630 Structure of Oryzias latipes enteropeptidase light chain 2013-03-26 2014-02-19 Xu, J.,Hu, S.,Wang, X.,Zhao, Z.,Zhang, X.,Wang, H.,Zhang, D.,Guo, Y. Structure basis for the unique specificity of medaka enteropeptidase light chain. Protein Cell 2014 5 178 181 4NOK 24407422 Crystal structure of proenzyme asparaginyl endopeptidase (AEP)/Legumain at pH 7.5 2013-11-19 2014-02-19 Zhao, L.,Hua, T.,Crowley, C.,Ru, H.,Ni, X.,Shaw, N.,Jiao, L.,Ding, W.,Qu, L.,Hung, L.W.,Huang, W.,Liu, L.,Ye, K.,Ouyang, S.,Cheng, G.,Liu, Z.J. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014 24 344 358 3WMW 24558034 GalE-like L-Threonine dehydrogenase from Cupriavidus necator (apo form) 2013-11-29 2014-02-26 Nakano, S.,Okazaki, S.,Tokiwa, H.,Asano, Y. Binding of NAD+ and L-Threonine Induces Stepwise Structural and Flexibility Changes in Cupriavidus necator L-Threonine Dehydrogenase J.Biol.Chem. 2014 289 10445 10454 3WMX 24558034 GalE-like L-Threonine dehydrogenase from Cupriavidus necator (holo form) 2013-11-29 2014-02-26 Nakano, S.,Okazaki, S.,Tokiwa, H.,Asano, Y. Binding of NAD+ and L-Threonine Induces Stepwise Structural and Flexibility Changes in Cupriavidus necator L-Threonine Dehydrogenase J.Biol.Chem. 2014 289 10445 10454 4JCL Crystal structure of Alpha-CGT from Paenibacillus macerans at 1.7 Angstrom resolution 2013-02-22 2014-02-26 Wu, L.,Zhou, J.,Wu, J.,Li, J. Crystal Structure of Alpha-Cgt from Paenibacillus Macerans at 1.7 Angstrom Resolution To be Published 0 0 0 0 4JD4 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-065 2013-02-23 2014-02-26 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-065 To be Published 0 0 0 0 4M0V 24531464 Crystal structure of E.coli SbcD with Mn2+ 2013-08-02 2014-02-26 Liu, S.,Tian, L.F.,Liu, Y.P.,An, X.M.,Tang, Q.,Yan, X.X.,Liang, D.C. Structural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repair. Acta Crystallogr.,Sect.D 2014 70 299 309 3W70 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-095 2013-02-27 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-095 To be Published 0 0 0 0 3W71 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-097 2013-02-27 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-097 To be Published 0 0 0 0 3W72 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-107 2013-02-27 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-107 To be Published 0 0 0 0 3W74 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-139 2013-02-27 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-139 To be Published 0 0 0 0 3W75 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-149 2013-02-27 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-149 To be Published 0 0 0 0 3W7D Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-170 2013-02-28 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-170 To be Published 0 0 0 0 3W7E Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-179 2013-02-28 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-179 To be Published 0 0 0 0 3W7K Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-066 2013-02-28 2014-03-05 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-066 To be Published 0 0 0 0 3WDQ 24570006 Crystal structure of beta-mannanase from a symbiotic protist of the termite Reticulitermes speratus 2013-06-20 2014-03-05 Tsukagoshi, H.,Nakamura, A.,Ishida, T.,Touhara, K.K.,Otagiri, M.,Moriya, S.,Samejima, M.,Igarashi, K.,Fushinobu, S.,Kitamoto, K.,Arioka, M. Structural and Biochemical Analyses of Glycoside Hydrolase Family 26 beta-Mannanase from a Symbiotic Protist of the Termite Reticulitermes speratus J.Biol.Chem. 2014 289 10843 10852 3WDR 24570006 Crystal structure of beta-mannanase from a symbiotic protist of the termite Reticulitermes speratus complexed with gluco-manno-oligosaccharide 2013-06-20 2014-03-05 Tsukagoshi, H.,Nakamura, A.,Ishida, T.,Touhara, K.K.,Otagiri, M.,Moriya, S.,Samejima, M.,Igarashi, K.,Fushinobu, S.,Kitamoto, K.,Arioka, M. Structural and Biochemical Analyses of Glycoside Hydrolase Family 26 beta-Mannanase from a Symbiotic Protist of the Termite Reticulitermes speratus J.Biol.Chem. 2014 289 10843 10852 3W7R Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097 2013-03-06 2014-03-12 Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K. Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097 To be Published 0 0 0 0 3WH1 24582745 Crystal Structure of a Family GH19 Chitinase from Bryum coronatum in complex with (GlcNAc)4 at 1.0 A resolution 2013-08-21 2014-03-26 Ohnuma, T.,Umemoto, N.,Nagata, T.,Shinya, S.,Numata, T.,Taira, T.,Fukamizo, T. Crystal structure of a ""loopless"" GH19 chitinase in complex with chitin tetrasaccharide spanning the catalytic center. Biochim.Biophys.Acta 2014 1844 793 802 4IJ4 24582745 Crystal Structure of a Family GH19 chitinase from Bryum coronatum in complex with (GlcNAc)4 2012-12-21 2014-03-26 Ohnuma, T.,Umemoto, N.,Nagata, T.,Shinya, S.,Numata, T.,Taira, T.,Fukamizo, T. Crystal structure of a ""loopless"" GH19 chitinase in complex with chitin tetrasaccharide spanning the catalytic center. Biochim.Biophys.Acta 2014 1844 793 802 4NBC 24584240 Oxygenase with Phe275 replaced by Trp and ferredoxin complex of carbazole 1,9a-dioxygenase (form1) 2013-10-23 2014-03-26 Inoue, K.,Usami, Y.,Ashikawa, Y.,Noguchi, H.,Umeda, T.,Yamagami-Ashikawa, A.,Horisaki, T.,Uchimura, H.,Terada, T.,Nakamura, S.,Shimizu, K.,Habe, H.,Yamane, H.,Fujimoto, Z.,Nojiri, H. Structural basis of the divergent oxygenation reactions catalyzed by the rieske nonheme iron oxygenase carbazole 1,9a-dioxygenase. Appl.Environ.Microbiol. 2014 80 2821 2832 3WGT 24644036 Crystal structure of D-amino acid oxidase mutant 2013-08-09 2014-04-02 Yasukawa, K.,Nakano, S.,Asano, Y. Tailoring D-amino acid oxidase from the pig kidney to R-stereoselective amine oxidase and its use in the deracemization of alpha-methylbenzylamine. Angew.Chem.Int.Ed.Engl. 2014 53 4428 4431 4N7N 24635037 Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. 2013-10-16 2014-04-02 Shibayama, N.,Sugiyama, K.,Tame, J.R.,Park, S.Y. Capturing the hemoglobin allosteric transition in a single crystal form J.Am.Chem.Soc. 2014 136 5097 5105 4N7O 24635037 Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. 2013-10-16 2014-04-02 Shibayama, N.,Sugiyama, K.,Tame, J.R.,Park, S.Y. Capturing the hemoglobin allosteric transition in a single crystal form J.Am.Chem.Soc. 2014 136 5097 5105 4N7P 24635037 Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. 2013-10-16 2014-04-02 Shibayama, N.,Sugiyama, K.,Tame, J.R.,Park, S.Y. Capturing the hemoglobin allosteric transition in a single crystal form J.Am.Chem.Soc. 2014 136 5097 5105 3WCR 24436051 Crystal structure of plant lectin (ligand-free form) 2013-05-31 2014-04-09 Nagae, M.,Soga, K.,Morita-Matsumoto, K.,Hanashima, S.,Ikeda, A.,Yamamoto, K.,Yamaguchi, Y. Phytohemagglutinin from Phaseolus vulgaris (PHA-E) displays a novel glycan recognition mode using a common legume lectin fold Glycobiology 2014 24 368 378 3WOG 24436051 Crystal structure plant lectin in complex with ligand 2013-12-26 2014-04-09 Nagae, M.,Soga, K.,Morita-Matsumoto, K.,Hanashima, S.,Ikeda, A.,Yamamoto, K.,Yamaguchi, Y. Phytohemagglutinin from Phaseolus vulgaris (PHA-E) displays a novel glycan recognition mode using a common legume lectin fold Glycobiology 2014 24 368 378 3WEZ Crystal structure of human beta-galactosidase in complex with NOEV 2013-07-16 2014-04-23 Suzuki, H.,Ohto, U.,Higaki, K.,Mena-Barragan, T.,Aguilar-Moncayo, M.,Ortiz Mellet, C.,Nanba, E.,Garcia Fernandez, J.M.,Suzuki, Y.,Shimizu, T. Structural basis of pharmacological chaperoning for human beta-galactosidase to be published 0 0 0 0 3WF0 Crystal structure of human beta-galactosidase in complex with 6S-NBI-DGJ 2013-07-16 2014-04-23 Suzuki, H.,Ohto, U.,Higaki, K.,Mena-Barragan, T.,Aguilar-Moncayo, M.,Ortiz Mellet, C.,Nanba, E.,Garcia Fernandez, J.M.,Suzuki, Y.,Shimizu, T. Structural basis of pharmacological chaperoning for human beta-galactosidase to be published 0 0 0 0 3WPM 24657997 Crystal structure of the anaerobic DesB-gallate complex by co-crystallization 2014-01-14 2014-04-30 Sugimoto, K.,Senda, M.,Kasai, D.,Fukuda, M.,Masai, E.,Senda, T. Molecular Mechanism of Strict Substrate Specificity of an Extradiol Dioxygenase, DesB, Derived from Sphingobium sp. SYK-6 Plos One 2014 9 0 0 4OKV Crystal structure of anopheline anti-platelet protein with Fab antibody 2014-01-23 2014-04-30 Sugiyama, K.,Iyori, M.,Sawaguchi, A.,Akashi, S.,Tame, J.R.H.,Yoshida, S.,Park, S.Y. The crystal structure of anopheles anti-platelet protein, a powerful anti-coagulant, in complex with an antibody To be Published 0 0 0 0 3WG8 24792952 Crystal structure of the abscisic acid receptor PYR1 in complex with an antagonist AS6 2013-07-31 2014-05-07 Takeuchi, J.,Okamoto, M.,Akiyama, T.,Muto, T.,Yajima, S.,Sue, M.,Seo, M.,Kanno, Y.,Kamo, T.,Endo, A.,Nambara, E.,Hirai, N.,Ohnishi, T.,Cutler, S.R.,Todoroki, Y. Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions Nat.Chem.Biol. 2014 10 477 482 4P0A 24726327 Crystal structure of HOIP PUB domain in complex with p97 PIM 2014-02-20 2014-05-07 Schaeffer, V.,Akutsu, M.,Olma, M.H.,Gomes, L.C.,Kawasaki, M.,Dikic, I. Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling. Mol.Cell 2014 54 349 361 4NFX 24816099 Structure and atypical hydrolysis mechanism of the Nudix hydrolase Orf153 (YmfB) from Escherichia coli 2013-11-01 2014-05-14 Hong, M.K.,Ribeiro, A.J.M.,Kim, J.K.,Ngo, H.P.T.,Kim, J.,Lee, C.H.,Ahn, Y.J.,Fernandes, P.A.,Li, Q.,Ramos, M.J.,Kang, L.W. Divalent metal ion-based catalytic mechanism of the Nudix hydrolase Orf153 (YmfB) from Escherichia coli Acta Crystallogr.,Sect.D 2014 70 1297 1310 4KTR 24828502 Crystal structure of 2-O-alpha-glucosylglycerol phosphorylase in complex with isofagomine and glycerol 2013-05-21 2014-05-21 Touhara, K.K.,Nihira, T.,Kitaoka, M.,Nakai, H.,Fushinobu, S. Structural basis for reversible phosphorolysis and hydrolysis reactions of 2-O-alpha-glucosylglycerol phosphorylase J.Biol.Chem. 2014 289 18067 18075 3WHO 24882409 X-ray-Crystallographic Structure of an RNase Po1 Exhibiting Anti-tumor Activity 2013-08-30 2014-07-02 Kobayashi, H.,Katsutani, T.,Hara, Y.,Motoyoshi, N.,Itagaki, T.,Akita, F.,Higashiura, A.,Yamada, Y.,Inokuchi, N.,Suzuki, M. X-ray crystallographic structure of RNase Po1 that exhibits anti-tumor activity. Biol.Pharm.Bull. 2014 37 968 978 4CQG 24657156 The crystal structure of MPK38 in complex with OTSSP167, an orally- administrative MELK selective inhibitor 2014-02-17 2014-07-09 Cho, Y.S.,Kang, Y.,Kim, K.,Cha, Y.J.,Cho, H.S. The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem.Biophys.Res.Commun. 2014 447 7 11 4Q2L 24952155 Atomic Resolution Structure of the E. coli YajR Transporter YAM Domain 2014-04-09 2014-07-09 Jiang, D.,Zhao, Y.,Fan, J.,Liu, X.,Wu, Y.,Feng, W.,Zhang, X.C. Atomic resolution structure of the E. coli YajR transporter YAM domain. Biochem.Biophys.Res.Commun. 2014 450 929 935 4OH9 25004971 Crystal Structure of the human MST2 SARAH homodimer 2014-01-17 2014-07-23 Hwang, E.,Cheong, H.K.,Mushtaq, A.U.,Kim, H.Y.,Yeo, K.J.,Kim, E.,Lee, W.C.,Hwang, K.Y.,Cheong, C.,Jeon, Y.H. Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway. Acta Crystallogr.,Sect.D 2014 70 1944 1953 3WJ2 25043762 Crystal structure of ESTFA (FE-lacking apo form) 2013-10-03 2014-07-30 Ohara, K.,Unno, H.,Oshima, Y.,Hosoya, M.,Fujino, N.,Hirooka, K.,Takahashi, S.,Yamashita, S.,Kusunoki, M.,Nakayama, T. Structural insights into the low pH adaptation of a unique carboxylesterase from Ferroplasma: altering the pH optima of two carboxylesterases. J.Biol.Chem. 2014 289 24499 24510 3WUQ 25058684 Structure of the entire stalk region of the dynein motor domain 2014-05-01 2014-08-06 Nishikawa, Y.,Oyama, T.,Kamiya, N.,Kon, T.,Toyoshima, Y.Y.,Nakamura, H.,Kurisu, G. Structure of the entire stalk region of the Dynein motor domain J.Mol.Biol. 2014 426 3232 3245 4MB2 24021277 Crystal structure of TON1374 in complex with ATP 2013-08-19 2014-08-06 Kim, M.-K.,An, Y.J.,Cha, S.-S. The crystal structure of a novel phosphopantothenate synthetase from the hyperthermophilic archaea, Thermococcus onnurineus NA1 Biochem.Biophys.Res.Commun. 2013 439 533 538 3WRY 25092327 Crystal structure of helicase complex 2 2014-02-27 2014-08-13 Ishibashi, K.,Kezuka, Y.,Kobayashi, C.,Kato, M.,Inoue, T.,Nonaka, T.,Ishikawa, M.,Matsumura, H.,Katoh, E. Structural basis for the recognition-evasion arms race between Tomato mosaic virus and the resistance gene Tm-1 Proc.Natl.Acad.Sci.USA 2014 111 0 0 4Q65 25066136 Structure of the E. coli Peptide Transporter YbgH 2014-04-21 2014-08-13 Zhao, Y.,Mao, G.,Liu, M.,Zhang, L.,Wang, X.,Zhang, X.C. Crystal structure of the E. coli peptide transporter YbgH. Structure 2014 22 1152 1160 4Q7J 25122749 Complex structure of viral RNA polymerase 2014-04-25 2014-08-27 Takeshita, D.,Yamashita, S.,Tomita, K. Molecular insights into replication initiation by Q beta replicase using ribosomal protein S1. Nucleic Acids Res. 2014 42 10809 10822 4QFJ The crystal structure of rat angiogenin-heparin complex 2014-05-21 2014-08-27 Yeo, K.J.,Hwang, E.,Min, K.M.,Hwang, K.Y.,Jeon, Y.H.,Chang, S.I.,Cheong, H.K. The crystal structure of rat angiogenin-heparin complex To be Published 0 0 0 0 3WOI 24827749 Crystal structure of the DAP BII (S657A) 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WOJ 24827749 Crystal structure of the DAP BII 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WOL 24827749 Crystal structure of the DAP BII dipeptide complex I 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WOM 24827749 Crystal structure of the DAP BII dipeptide complex II 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WON 24827749 Crystal structure of the DAP BII dipeptide complex III 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WOO 24827749 Crystal structure of the DAP BII hexapeptide complex I 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WOP 24827749 Crystal structure of the DAP BII hexapeptide complex II 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WOQ 24827749 Crystal structure of the DAP BII hexapeptide complex III 2013-12-29 2014-09-03 Sakamoto, Y.,Suzuki, Y.,Iizuka, I.,Tateoka, C.,Roppongi, S.,Fujimoto, M.,Inaka, K.,Tanaka, H.,Masaki, M.,Ohta, K.,Okada, H.,Nonaka, T.,Morikawa, Y.,Nakamura, K.T.,Ogasawara, W.,Tanaka, N. S46 peptidases are the first exopeptidases to be members of clan PA SCI REP 2014 4 4977 4977 3WIJ Crystal structure of a plant class V chitinase mutant from Cycas revoluta in complex with (GlcNAc)3 2013-09-13 2014-09-17 Numata, T.,Osawa, T.,Umemoto, N.,Ohnuma, T.,Fukamizo, T. Crystal structure of a plant class V chitinase mutant from Cycas revoluta in complex with (GlcNAc)3 To be Published 0 0 0 0 4MNM Crystal Structure of GH18 Chitinase (G77W/E119Q mutant) from Cycas revoluta in complex with (GlcNAc)4 2013-09-11 2014-09-17 Umemoto, N.,Numata, T.,Ohnuma, T.,Osawa, T.,Taira, T.,Fukamizo, T. Crystal Structure of GH18 Chitinase from Cycad, Cycas revoluta To be Published 0 0 0 0 3WIL Crystal structure of the CK2alpha/compound3 complex 2013-09-18 2014-09-24 Nakanishi, I.,Murata, K.,Nagata, N.,Kurono, M.,Kinoshita, T.,Yasue, M.,Miyazaki, T.,Hirasawa, A.,Tsujimoto, G.,Kitaura, K. Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening To be Published 0 0 0 0 3WWV 25349784 C-terminal domain of stomatin operon partner protein 1510-C from Pyrococcus horikoshii 2014-06-30 2014-10-01 Yokoyama, H.,Matsui, I. Crystal structure of the stomatin operon partner protein from Pyrococcus horikoshii indicates the formation of a multimeric assembly FEBS Open Bio 2014 4 804 812 3WW7 25288768 Crystal structure of the computationally designed Pizza2 protein 2014-06-17 2014-10-08 Voet, A.R.D.,Noguchi, H.,Addy, C.,Simoncini, D.,Terada, D.,Unzai, S.,Park, S.Y.,Zhang, K.Y.J.,Tame, J.R.H. Computational design of a self-assembling symmetrical beta-propeller protein. Proc.Natl.Acad.Sci.USA 2014 111 15102 15107 3WW8 25288768 Crystal structure of the computationally designed Pizza3 protein 2014-06-17 2014-10-08 Voet, A.R.D.,Noguchi, H.,Addy, C.,Simoncini, D.,Terada, D.,Unzai, S.,Park, S.Y.,Zhang, K.Y.J.,Tame, J.R.H. Computational design of a self-assembling symmetrical beta-propeller protein. Proc.Natl.Acad.Sci.USA 2014 111 15102 15107 3WW9 25288768 Crystal structure of the computationally designed Pizza6 protein 2014-06-17 2014-10-08 Voet, A.R.D.,Noguchi, H.,Addy, C.,Simoncini, D.,Terada, D.,Unzai, S.,Park, S.Y.,Zhang, K.Y.J.,Tame, J.R.H. Computational design of a self-assembling symmetrical beta-propeller protein. Proc.Natl.Acad.Sci.USA 2014 111 15102 15107 3WWA 25288768 Crystal structure of the computationally designed Pizza7 protein after heat treatment 2014-06-17 2014-10-08 Voet, A.R.D.,Noguchi, H.,Addy, C.,Simoncini, D.,Terada, D.,Unzai, S.,Park, S.Y.,Zhang, K.Y.J.,Tame, J.R.H. Computational design of a self-assembling symmetrical beta-propeller protein. Proc.Natl.Acad.Sci.USA 2014 111 15102 15107 3WWB 25288768 Crystal structure of the computationally designed Pizza2-SR protein 2014-06-17 2014-10-08 Voet, A.R.D.,Noguchi, H.,Addy, C.,Simoncini, D.,Terada, D.,Unzai, S.,Park, S.Y.,Zhang, K.Y.J.,Tame, J.R.H. Computational design of a self-assembling symmetrical beta-propeller protein. Proc.Natl.Acad.Sci.USA 2014 111 15102 15107 3WWF 25288768 Crystal structure of the computationally designed Pizza2-SR protein 2014-06-17 2014-10-08 Voet, A.R.D.,Noguchi, H.,Addy, C.,Simoncini, D.,Terada, D.,Unzai, S.,Park, S.Y.,Zhang, K.Y.J.,Tame, J.R.H. Computational design of a self-assembling symmetrical beta-propeller protein. Proc.Natl.Acad.Sci.USA 2014 111 15102 15107 3WJ5 Crystal structure of PPARgamma ligand binding domain in complex with triphenyltin 2013-10-04 2014-10-15 Harada, S.,Hiromori, Y.,Fukakusa, S.,Kawahara, K.,Nakamura, S.,Noda, M.,Uchiyama, S.,Fukui, K.,Nishikawa, J.,Nagase, H.,Kobayashi, Y.,Ohkubo, T.,Yoshida, T.,Nakanishi, T. 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Chemistry 2018 24 18052 18058 5ZTK 30455349 Synchrotron structure of light-driven chloride pump having an NTQ motif 2018-05-04 2018-12-05 Yun, J.H.,Li, X.,Park, J.H.,Wang, Y.,Ohki, M.,Jin, Z.,Lee, W.,Park, S.Y.,Hu, H.,Li, C.,Zatsepin, N.,Hunter, M.S.,Sierra, R.G.,Koralek, J.,Yoon, C.H.,Cho, H.S.,Weierstall, U.,Tang, L.,Liu, H.,Lee, W. Non-cryogenic structure of a chloride pump provides crucial clues to temperature-dependent channel transport efficiency J. Biol. Chem. 2019 294 794 804 6A97 30337538 Crystal structure of MHC-like MILL2 2018-07-11 2018-12-05 Kajikawa, M.,Ose, T.,Fukunaga, Y.,Okabe, Y.,Matsumoto, N.,Yonezawa, K.,Shimizu, N.,Kollnberger, S.,Kasahara, M.,Maenaka, K. Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility. Nat Commun 2018 9 4330 4330 5YY9 30639225 Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 2017-12-08 2018-12-12 Kori, S.,Ferry, L.,Matano, S.,Jimenji, T.,Kodera, N.,Tsusaka, T.,Matsumura, R.,Oda, T.,Sato, M.,Dohmae, N.,Ando, T.,Shinkai, Y.,Defossez, P.A.,Arita, K. Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure 2019 27 485 0 5Z1D 30449673 MAP2K7 C276S mutant-inhibitor 2017-12-26 2019-01-02 Shraga, A.,Olshvang, E.,Davidzohn, N.,Khoshkenar, P.,Germain, N.,Shurrush, K.,Carvalho, S.,Avram, L.,Albeck, S.,Unger, T.,Lefker, B.,Subramanyam, C.,Hudkins, R.L.,Mitchell, A.,Shulman, Z.,Kinoshita, T.,London, N. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor. Cell Chem Biol 2019 26 98 0 6AJM 30612860 Crystal structure of apo AtaTR 2018-08-28 2019-01-02 Yashiro, Y.,Yamashita, S.,Tomita, K. 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Sci Rep 2019 9 2330 2330 6AE1 30639408 Crystal structure of Csm2 of the type III-A CRISPR-Cas effector complex 2018-08-03 2019-01-23 Takeshita, D.,Sato, M.,Inanaga, H.,Numata, T. Crystal Structures of Csm2 and Csm3 in the Type III-A CRISPR-Cas Effector Complex. J. Mol. Biol. 2019 431 748 763 6AE2 30639408 Crystal structure of Csm3 of the type III-A CRISPR-Cas effector complex 2018-08-03 2019-01-23 Takeshita, D.,Sato, M.,Inanaga, H.,Numata, T. Crystal Structures of Csm2 and Csm3 in the Type III-A CRISPR-Cas Effector Complex. J. Mol. Biol. 2019 431 748 763 6AGH 30699349 Crystal structure of EFHA1 in Apo-State 2018-08-11 2019-01-23 Xing, Y.,Wang, M.,Wang, J.,Nie, Z.,Wu, G.,Yang, X.,Shen, Y. Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter. Cell Rep 2019 26 1203 0 5Z71 Crystal structure of the Homo Sapiens cytoplasmic ribosomal decoding site in complex with G418 (P21212 form) 2018-01-26 2019-01-30 Kanazawa, H.,Tsurumi, N.,Baasov, T.,Kondo, J. 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Nat Commun 2019 10 1960 1960 6A6U 30700768 Crystal structure of the modified fructosyl peptide oxidase from Aspergillus nidulans with R61G mutation, in complex with FSA 2018-06-29 2019-05-15 Ogawa, N.,Kimura, T.,Umehara, F.,Katayama, Y.,Nagai, G.,Suzuki, K.,Aisaka, K.,Maruyama, Y.,Itoh, T.,Hashimoto, W.,Murata, K.,Ichimura, M. Creation of haemoglobin A1c direct oxidase from fructosyl peptide oxidase by combined structure-based site specific mutagenesis and random mutagenesis. Sci Rep 2019 9 942 942 6A6V 30700768 Crystal structure of the modified fructosyl peptide oxidase from Aspergillus nidulans with 7 additional mutations, in complex with FSA 2018-06-29 2019-05-15 Ogawa, N.,Kimura, T.,Umehara, F.,Katayama, Y.,Nagai, G.,Suzuki, K.,Aisaka, K.,Maruyama, Y.,Itoh, T.,Hashimoto, W.,Murata, K.,Ichimura, M. Creation of haemoglobin A1c direct oxidase from fructosyl peptide oxidase by combined structure-based site specific mutagenesis and random mutagenesis. 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J.Am.Chem.Soc. 2021 143 2078 2087 7CTR 33340163 Closed form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H 2020-08-20 2021-02-03 Emori, M.,Numoto, N.,Senga, A.,Bekker, G.J.,Kamiya, N.,Kobayashi, Y.,Ito, N.,Kawai, F.,Oda, M. Structural basis of mutants of PET-degrading enzyme from Saccharomonospora viridis AHK190 with high activity and thermal stability. Proteins 2021 89 502 511 7CTS 33340163 Open form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H and S176A inactivation 2020-08-20 2021-02-03 Emori, M.,Numoto, N.,Senga, A.,Bekker, G.J.,Kamiya, N.,Kobayashi, Y.,Ito, N.,Kawai, F.,Oda, M. Structural basis of mutants of PET-degrading enzyme from Saccharomonospora viridis AHK190 with high activity and thermal stability. Proteins 2021 89 502 511 7DAY Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in TDP013-, and GSH-bound form 2020-10-18 2021-02-10 Koiwai, K.,Morohashi, K.,Inaba, K.,Ebihara, K.,Kojima, H.,Okabe, T.,Yoshino, R.,Hirokawa, T.,Nampo, T.,Fujikawa, Y.,Inoue, H.,Yumoto, F.,Senda, T.,Niwa, R. Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S -transferase Noppera-bo J Pestic Sci 2021 46 75 87 7C52 33597527 Co-crystal structure of a photosynthetic LH1-RC in complex with electron donor HiPIP 2020-05-18 2021-03-03 Kawakami, T.,Yu, L.J.,Liang, T.,Okazaki, K.,Madigan, M.T.,Kimura, Y.,Wang-Otomo, Z.Y. Crystal structure of a photosynthetic LH1-RC in complex with its electron donor HiPIP. Nat Commun 2021 12 1104 1104 6M4I Structure of CENP-E motor domain at 1.9 angstrom resolution 2020-03-07 2021-03-10 Shibuya, A.,Ogo, N.,Sawada, J.,Asai, A.,Yokoyama, H. Structure and comparison of the motor domain ofcentromere-associated protein E Acta Crystallogr.,Sect.D 2021 77 280 287 7DA2 33439149 The crystal structure of the chicken FANCM-MHF complex 2020-10-14 2021-03-17 Ito, S.,Nishino, T. Structural analysis of the chicken FANCM-MHF complex and its stability. Acta Crystallogr.,Sect.F 2021 77 1 7 7D6R 33972673 Crystal structure of the Stx2a complexed with MMA betaAla peptide 2020-10-01 2021-04-14 Watanabe-Takahashi, M.,Tamada, M.,Senda, M.,Hibino, M.,Shimizu, E.,Okuta, A.,Miyazawa, A.,Senda, T.,Nishikawa, K. Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin. Commun Biol 2021 4 538 538 7CJ7 33838083 Crystal structure of homo dimeric D-allulose 3-epimerase from Methylomonas sp. in complex with L-tagatose 2020-07-09 2021-04-21 Yoshida, H.,Yoshihara, A.,Kato, S.,Mochizuki, S.,Akimitsu, K.,Izumori, K.,Kamitori, S. Crystal structure of a novel homodimeric l-ribulose 3-epimerase from Methylomonus sp. Febs Open Bio 2021 11 1621 1637 7C5W 34006275 Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with iodide 2020-05-20 2021-04-28 Hirakawa, Y.,Senda, M.,Fukuda, K.,Yu, H.Y.,Ishida, M.,Taira, M.,Kinbara, K.,Senda, T. Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol. 2021 19 105 105 7E9J 33893702 Crystal Structure of POMGNT2 in complex with UDP 2021-03-04 2021-05-05 Imae, R.,Kuwabara, N.,Manya, H.,Tanaka, T.,Tsuyuguchi, M.,Mizuno, M.,Endo, T.,Kato, R. The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on alpha-dystroglycan. Genes Cells 2021 26 485 494 7CE4 33520373 Tankyrase2 catalytic domain in complex with K-476 2020-06-22 2021-05-12 Kinosada, H.,Okada-Iwasaki, R.,Kunieda, K.,Suzuki-Imaizumi, M.,Takahashi, Y.,Miyagi, H.,Suzuki, M.,Motosawa, K.,Watanabe, M.,Mie, M.,Ishii, T.,Ishida, H.,Saito, J.I.,Nakai, R. The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8 + T cells to tumors. Am J Cancer Res 2021 11 264 276 7CIN 33425247 Crystal structure of the extended-spectrum class C beta-lactamase AmpC BER with the ordered R2 loop 2020-07-07 2021-05-19 Jeong, B.G.,Na, J.H.,Bae, D.W.,Park, S.B.,Lee, H.S.,Cha, S.S. Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against beta-lactamases. Comput Struct Biotechnol J 2021 19 145 152 7CQD 33950020 The NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 235 and 236 2020-08-10 2021-05-19 Tamura-Sakaguchi, R.,Aruga, R.,Hirose, M.,Ekimoto, T.,Miyake, T.,Hizukuri, Y.,Oi, R.,Kaneko, M.K.,Kato, Y.,Akiyama, Y.,Ikeguchi, M.,Iwasaki, K.,Nogi, T. Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion. Acta Crystallogr D Struct Biol 2021 77 645 662 7DHW 35173046 Crystal structure of myosin-XI motor domain in complex with ADP-ALF4 2020-11-17 2021-05-19 Haraguchi, T.,Tamanaha, M.,Suzuki, K.,Yoshimura, K.,Imi, T.,Tominaga, M.,Sakayama, H.,Nishiyama, T.,Murata, T.,Ito, K. Discovery of ultrafast myosin, its amino acid sequence, and structural features. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7C4P Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA 2020-05-18 2021-05-26 Jin, Z.,Park, J.H.,Yun, J.H.,Park, S.Y.,Lee, W. Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA To Be Published 0 0 0 0 7C4Q Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA 2020-05-18 2021-05-26 Jin, Y.,Park, J.H.,Yun, J.H.,Park, S.Y.,Lee, W. Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA To Be Published 0 0 0 0 7C4R Crystal structure of hydrogen peroxide treated zebrafish TRF2 complexed with DNA 2020-05-18 2021-05-26 Jin, Z.,Park, J.H.,Yun, J.H.,Park, S.Y.,Lee, W. Crystal structure of hydrogen peroxide treated zebrafish TRF2 myb-domain complexed with DNA To Be Published 0 0 0 0 7C8N 33938220 Crystal structure of IscU H106A variant 2020-06-03 2021-05-26 Kunichika, K.,Nakamura, R.,Fujishiro, T.,Takahashi, Y. The Structure of the Dimeric State of IscU Harboring Two Adjacent [2Fe-2S] Clusters Provides Mechanistic Insights into Cluster Conversion to [4Fe-4S]. Biochemistry 2021 60 1569 1572 7C8O Crystal structure of IscU D40A/H106A variant 2020-06-03 2021-06-09 Kunichika, K.,Fujishiro, T.,Takahashi, Y. [2Fe-2S] clusters-assembled dimeric structures of IscU iron-sulfur scaffold to be published 0 0 0 0 7CEA 34188035 Crystal structure of HUTS-4 Fv-clasp fragment 2020-06-22 2021-06-23 Arimori, T.,Miyazaki, N.,Mihara, E.,Takizawa, M.,Taniguchi, Y.,Cabanas, C.,Sekiguchi, K.,Takagi, J. Structural mechanism of laminin recognition by integrin. Nat Commun 2021 12 4012 4012 7D0M 34172584 Crystal structure of mouse CRY1 with bound cryoprotectant 2020-09-11 2021-06-23 Miller, S.,Srivastava, A.,Nagai, Y.,Aikawa, Y.,Tama, F.,Hirota, T. Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7D0N 34172584 Crystal structure of mouse CRY2 apo form 2020-09-11 2021-06-23 Miller, S.,Srivastava, A.,Nagai, Y.,Aikawa, Y.,Tama, F.,Hirota, T. Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7DDA 34106826 Envelope protein VP37 a crystal structure from White Spot Syndrome Virus 2020-10-28 2021-06-23 Somsoros, W.,Sangawa, T.,Takebe, K.,Attarataya, J.,Wongprasert, K.,Senapin, S.,Rattanarojpong, T.,Suzuki, M.,Khunrae, P. Crystal structure of the C-terminal domain of envelope protein VP37 from white spot syndrome virus reveals sulphate binding sites responsible for heparin binding. J.Gen.Virol. 2021 102 0 0 7E18 34313428 Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor YH-53 2021-02-01 2021-06-23 Konno, S.,Kobayashi, K.,Senda, M.,Funai, Y.,Seki, Y.,Tamai, I.,Schakel, L.,Sakata, K.,Pillaiyar, T.,Taguchi, A.,Taniguchi, A.,Gutschow, M.,Muller, C.E.,Takeuchi, K.,Hirohama, M.,Kawaguchi, A.,Kojima, M.,Senda, T.,Shirasaka, Y.,Kamitani, W.,Hayashi, Y. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J.Med.Chem. 2022 65 2926 2939 7E19 34313428 Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor SH-5 2021-02-01 2021-06-23 Konno, S.,Kobayashi, K.,Senda, M.,Funai, Y.,Seki, Y.,Tamai, I.,Schakel, L.,Sakata, K.,Pillaiyar, T.,Taguchi, A.,Taniguchi, A.,Gutschow, M.,Muller, C.E.,Takeuchi, K.,Hirohama, M.,Kawaguchi, A.,Kojima, M.,Senda, T.,Shirasaka, Y.,Kamitani, W.,Hayashi, Y. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. 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Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7CET 35395703 Crystal structure of D-cycloserine-bound form of cysteine desulfurase NifS from Helicobacter pylori 2020-06-24 2021-06-30 Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T. Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J. 2022 0 0 0 7F52 Crystal Structure of IBV Nsp2 2021-06-21 2021-07-21 Ming, Z.,Li, Y.,Yan, L.,Lou, Z.,Rao, Z. Crystal Structure of IBV Nsp2 To Be Published 0 0 0 0 7EA0 34274549 Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 1 2021-03-05 2021-08-04 Akaki, T.,Bessho, Y.,Ito, T.,Fujioka, S.,Ubukata, M.,Mori, G.,Yamanaka, K.,Orita, T.,Doi, S.,Iwanaga, T.,Ikegashira, K.,Hantani, Y.,Nakanishi, I.,Adachi, T. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg.Med.Chem. 2021 44 116283 116283 7EAT 34274549 Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with compound 1 2021-03-08 2021-08-04 Akaki, T.,Bessho, Y.,Ito, T.,Fujioka, S.,Ubukata, M.,Mori, G.,Yamanaka, K.,Orita, T.,Doi, S.,Iwanaga, T.,Ikegashira, K.,Hantani, Y.,Nakanishi, I.,Adachi, T. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg.Med.Chem. 2021 44 116283 116283 7EHF 34310216 Crystal structure of the aminoglycoside resistance methyltransferase NpmB1 2021-03-29 2021-08-11 Kawai, A.,Suzuki, M.,Tsukamoto, K.,Minato, Y.,Doi, Y. Functional and Structural Characterization of Acquired 16S rRNA Methyltransferase NpmB1 Conferring Pan-Aminoglycoside Resistance. Antimicrob.Agents Chemother. 2021 65 0 0 7FBT 34358705 Crystal structure of chitinase (RmChi1) from Rhizomucor miehei (sp p32 2 1, MR) 2021-07-12 2021-08-11 Jiang, Z.,Hu, S.,Ma, J.,Liu, Y.,Qiao, Z.,Yan, Q.,Gao, Y.,Yang, S. Crystal structure of a chitinase (RmChiA) from the thermophilic fungus Rhizomucor miehei with a real active site tunnel. Biochim Biophys Acta Proteins 2021 1869 140709 140709 7DVE 34583991 Crystal structure of FAD-dependent C-glycoside oxidase 2021-01-13 2021-09-08 Kumano, T.,Hori, S.,Watanabe, S.,Terashita, Y.,Yu, H.Y.,Hashimoto, Y.,Senda, T.,Senda, M.,Kobayashi, M. FAD-dependent C -glycoside-metabolizing enzymes in microorganisms: Screening, characterization, and crystal structure analysis. Proc.Natl.Acad.Sci.USA 2021 118 0 0 7E0A 34471049 X-ray structure of human PPARgamma ligand binding domain-saroglitazar co-crystals obtained by co-crystallization 2021-01-27 2021-09-08 Honda, A.,Kamata, S.,Satta, C.,Machida, Y.,Uchii, K.,Terasawa, K.,Nemoto, A.,Oyama, T.,Ishii, I. Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR alpha / gamma Dual Agonist. Biol.Pharm.Bull. 2021 44 1210 1219 7E5O 34508662 Crystal structure of SARS-CoV-2 RBD in complex with antibody NT-193 2021-02-19 2021-09-08 Onodera, T.,Kita, S.,Adachi, Y.,Moriyama, S.,Sato, A.,Nomura, T.,Sakakibara, S.,Inoue, T.,Tadokoro, T.,Anraku, Y.,Yumoto, K.,Tian, C.,Fukuhara, H.,Sasaki, M.,Orba, Y.,Shiwa, N.,Iwata, N.,Nagata, N.,Suzuki, T.,Sasaki, J.,Sekizuka, T.,Tonouchi, K.,Sun, L.,Fukushi, S.,Satofuka, H.,Kazuki, Y.,Oshimura, M.,Kurosaki, T.,Kuroda, M.,Matsuura, Y.,Suzuki, T.,Sawa, H.,Hashiguchi, T.,Maenaka, K.,Takahashi, Y. A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site. Immunity 2021 54 2385 0 7DEV 33743393 Crystal Structures of Anthocyanin 5,3'-aromatic acyltransferase from Gentiana triflora 2020-11-05 2021-09-15 Murayama, K.,Kato-Murayama, M.,Sato, T.,Hosaka, T.,Ishiguro, K.,Mizuno, T.,Kitao, K.,Honma, T.,Yokoyama, S.,Tanaka, Y.,Shirouzu, M. Anthocyanin 5,3'-aromatic acyltransferase from Gentiana triflora, a structural insight into biosynthesis of a blue anthocyanin. Phytochemistry 2021 186 112727 112727 7D5N Crystal structure of inositol dehydrogenase homolog complexed with NADH and myo-inositol from Azotobacter vinelandii 2020-09-27 2021-09-29 Fukano, K.,Ono, T.,Suzuki, M.,Takenoya, M.,Ito, S.,Sasaki, Y.,Yajima, S. Crystal structure of inositol dehydrogenase complexed with NADH and myo-inositol from Azotobacter vinelandii To Be Published 0 0 0 0 7E96 34804547 Oxy-deoxy intermediate of 400 kDa giant hemoglobin at 69% oxygen saturation 2021-03-03 2021-10-06 Numoto, N.,Kawano, Y.,Okumura, H.,Baba, S.,Fukumori, Y.,Miki, K.,Ito, N. Coarse snapshots of oxygen-dissociation intermediates of a giant hemoglobin elucidated by determining the oxygen saturation in individual subunits in the crystalline state. Iucrj 2021 8 954 962 7E97 34804547 Oxy-deoxy intermediate of 400 kDa giant hemoglobin at 58% oxygen saturation 2021-03-03 2021-10-06 Numoto, N.,Kawano, Y.,Okumura, H.,Baba, S.,Fukumori, Y.,Miki, K.,Ito, N. Coarse snapshots of oxygen-dissociation intermediates of a giant hemoglobin elucidated by determining the oxygen saturation in individual subunits in the crystalline state. Iucrj 2021 8 954 962 7DT3 34225167 Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 2021-01-04 2021-10-13 Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem. 2021 44 116292 116292 7DT5 34225167 Crystal structure of human transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid 2021-01-04 2021-10-13 Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem. 2021 44 116292 116292 7DT8 34225167 Crystal structure of V30M mutated transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid 2021-01-04 2021-10-13 Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem. 2021 44 116292 116292 7EJQ 34225167 Crystal structure of human transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid 2021-04-02 2021-10-13 Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem. 2021 44 116292 116292 7EJR 34225167 Crystal structure of V30M mutated transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid 2021-04-02 2021-10-13 Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem. 2021 44 116292 116292 7DNM Crystal structure of the AgCarB2-C2 complex 2020-12-10 2021-10-20 Mori, T.,Kumano, T.,He, K.,Awakawa, T.,Watanabe, S.,Hori, S.,Terashita, Y.,Hashimoto, Y.,Senda, M.,Senda, T.,Kobayashi, M.,Abe, I. Structural basis for the metabolism of xenobiotic C-glycosides by intestinal bacteria Nat Commun 2021 0 0 0 7DCK 35362475 Crystal structure of phosphodiesterase tw9814 2020-10-26 2021-10-27 Heo, Y.,Park, S.B.,Jeon, Y.E.,Yun, J.H.,Jeong, B.G.,Cha, S.S.,Lee, W. Structural and functional identification of the uncharacterized metallo-beta-lactamase superfamily protein TW9814 as a phosphodiesterase with unique metal coordination. Acta Crystallogr D Struct Biol 2022 78 532 541 7EXB 34728636 DfgA-DfgB complex apo 2.4 angstrom 2021-05-26 2021-11-03 Mori, T.,Kumano, T.,He, H.,Watanabe, S.,Senda, M.,Moriya, T.,Adachi, N.,Hori, S.,Terashita, Y.,Kawasaki, M.,Hashimoto, Y.,Awakawa, T.,Senda, T.,Abe, I.,Kobayashi, M. C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nat Commun 2021 12 6294 6294 7ERH 34547896 Crystal structure of WT-TTR in complex with bithionol 2021-05-06 2021-11-24 Yokoyama, T.,Kashihara, M.,Mizuguchi, M. Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J.Med.Chem. 2021 64 14344 14357 7ERJ 34547896 Crystal structure of V30M-TTR in complex with dichlorophen 2021-05-06 2021-11-24 Yokoyama, T.,Kashihara, M.,Mizuguchi, M. Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J.Med.Chem. 2021 64 14344 14357 7F37 Crystal structure of AtaT2-AtaR2 complex 2021-06-15 2021-12-22 Yashiro, Y.,Zhang, C.,Sakaguchi, Y.,Suzuki, T.,Tomita, K. Molecular basis of glycyl-tRNAGly acetylation by TacT from Salmonella Typhimurium Cell Rep 2021 37 110130 0 7DQC Crystal structure of nucleotide-free mutant A(S23C)3B(N64C)3 complex from Enterococcus hirae V-ATPase 2020-12-23 2021-12-29 Imamura, M.,Maruyama, S.,Nakamoto, K.,Kawai, F.,Akiyama, T.,Mizutani, K.,Suzuki, K.,Shirouzu, M.,Iino, R.,Uchihashi, T.,Ando, T.,Murata, T. The combination of high-speed AFM and X-ray crystallography reveals rotary catalytic mechanism of shaftless V1-ATPase To Be Published 0 0 0 0 7EBT 35172816 Crystal structure of Aedes aegypti Noppera-bo, glutathione S-transferase epsilon 8, in glutathione-bound form 2021-03-11 2022-01-26 Inaba, K.,Ebihara, K.,Senda, M.,Yoshino, R.,Sakuma, C.,Koiwai, K.,Takaya, D.,Watanabe, C.,Watanabe, A.,Kawashima, Y.,Fukuzawa, K.,Imamura, R.,Kojima, H.,Okabe, T.,Uemura, N.,Kasai, S.,Kanuka, H.,Nishimura, T.,Watanabe, K.,Inoue, H.,Fujikawa, Y.,Honma, T.,Hirokawa, T.,Senda, T.,Niwa, R. Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. Bmc Biol. 2022 20 43 43 7E4D 35101610 Crystal structure of PlDBR 2021-02-11 2022-02-02 Kamimura, N.,Watanabe, S.,Sugimoto, K.,Senda, M.,Araki, T.,Yu, H.Y.,Hishiyama, S.,Kajita, S.,Senda, T.,Masai, E. Exploration and structure-based engineering of alkenal double bond reductases catalyzing the C alpha C beta double bond reduction of coniferaldehyde. N Biotechnol 2022 68 57 67 7V5N 35114463 Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer 2021-08-17 2022-02-02 Saito, T.,Shimizu, Y.,Tsukakoshi, K.,Abe, K.,Lee, J.,Ueno, K.,Asano, R.,Jones, B.V.,Yamada, T.,Nakano, T.,Tong, J.,Hishiki, A.,Hara, K.,Hashimoto, H.,Sode, K.,Toyo'oka, T.,Todoroki, K.,Ikebukuro, K. Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection. Biosens.Bioelectron. 2022 203 114027 114027 7W6D 34939812 Polyketide cyclase OAC-F24I mutant from Cannabis sativa in complex with olivetolic acid 2021-12-01 2022-02-02 Lee, Y.E.,Nakashima, Y.,Kodama, T.,Chen, X.,Morita, H. Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs. Org.Lett. 2022 24 410 414 7VBX Crystal structure of human pyruvate dehydrogenase kinase 2 in complex with compound 20 2021-09-01 2022-02-16 Bessho, Y.,Akaki, T.,Hara, Y.,Yamakawa, M.,Obika, S.,Mori, G.,Ubukata, M.,Yasue, K.,Nakane, Y.,Terasako, Y.,Orita, T.,Doi, S.,Iwanaga, T.,Fujishima, A.,Adachi, T.,Ueno, H.,Motomura, T. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg.Med.Chem. 2021 52 116514 0 7VR9 Crystal structure of human serum albumin complex with aripiprazole and myristic acid 2021-10-22 2022-02-16 Hirata, K.,Kawai, A.,Chuang, V.T.G.,Sakurama, K.,Nishi, K.,Yamasaki, K.,Otagiri, M. Effects of Myristate on the Induced Circular Dichroism Spectra of Aripiprazole Bound to Human Serum Albumin: A Structural-Chemical Investigation Acs Omega 2022 7 4413 4419 7E6A 35395703 Crystal structure of cysteine desulfurase SufS C361A from Bacillus subtilis 2021-02-22 2022-03-02 Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T. Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J. 2022 289 5947 5970 7E6B 35395703 Crystal structure of PMP-bound form of cysteine desulfurase SufS C361A from Bacillus subtilis 2021-02-22 2022-03-02 Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T. Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J. 2022 289 5947 5970 7E6C 35395703 Crystal structure of L-cycloserine-bound form of cysteine desulfurase SufS C361A from Bacillus subtilis 2021-02-22 2022-03-02 Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T. Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J. 2022 289 5947 5970 7E6F 35395703 Crystal structure of PMP-bound form of cysteine desulfurase SufS R376A from Bacillus subtilis in L-cycloserine-inhibition 2021-02-22 2022-03-02 Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T. Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J. 2022 289 5947 5970 7EAQ DNA quadruplex composed of i-motif and Z-DNA 2021-03-08 2022-03-09 Kondo, J.,Igarashi, Y. DNA quadruplex composed of i-motif and Z-DNA To Be Published 0 0 0 0 7EAY DNA containing Cu(II)-mediated 4-N-carboxymethylcytosine base pairs 2021-03-08 2022-03-09 Kondo, J.,Terashima, A.,Yoshimura, A.,Tada, Y.,Ono, A. DNA containing Cu(II)-mediated 4-N-carboxymethylcytosine base pairs To Be Published 0 0 0 0 7F88 34939106 Crystal structure of GH19 chitinase lacking the third loop structure 2021-07-01 2022-03-09 Kawamoto, D.,Takashima, T.,Fukamizo, T.,Numata, T.,Ohnuma, T. A conserved loop structure of GH19 chitinases assists the enzyme function from behind the core-functional region. Glycobiology 2022 32 356 364 7VQP 35053278 Vitamin D receptor complexed with a lithocholic acid derivative 2021-10-20 2022-03-09 Yoshihara, A.,Kawasaki, H.,Masuno, H.,Takada, K.,Numoto, N.,Ito, N.,Hirata, N.,Kanda, Y.,Ishizawa, M.,Makishima, M.,Kagechika, H.,Tanatani, A. Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists. Biomolecules 2022 12 0 0 7ECK RNA duplex containing C-Ag-A and U-Ag-A base pairs 2021-03-12 2022-03-16 Kondo, J.,Uchida, Y. RNA duplex containing C-Ag-A and U-Ag-A base pairs To Be Published 0 0 0 0 7ECN RNA duplex containing C-Ag-A base pairs 2021-03-12 2022-03-16 Kondo, J.,Tsudura, A. RNA duplex containing C-Ag-A base pairs To Be Published 0 0 0 0 7ECO RNA duplex containing U-Ag-U base pairs 2021-03-12 2022-03-16 Kondo, J.,Tsudura, A. RNA duplex containing U-Ag-U base pairs To Be Published 0 0 0 0 7ECP RNA duplex containing C-Ag-U 2021-03-12 2022-03-16 Kondo, J.,Tsudura, A. RNA duplex containing C-Ag-U To Be Published 0 0 0 0 7EDU RNA duplex containing C-Au-C base pair 2021-03-17 2022-03-23 Kondo, J.,Iwase, E. RNA duplex containing C-Au-C base pair To Be Published 0 0 0 0 7EDV DNA duplex containing C-G-Au-C base triple 2021-03-17 2022-03-23 Kondo, J.,Iwase, E. DNA duplex containing C-G-Au-C base triple To Be Published 0 0 0 0 7EDW DNA duplex containing T-T base pairs in complex with Au(III) 2021-03-17 2022-03-23 Kondo, J.,Iwase, E. DNA duplex containing T-T base pairs in complex with Au(III) To Be Published 0 0 0 0 7EEM RNA bulged-G motif 2021-03-19 2022-03-23 Kondo, J.,Sekiguchi, S. RNA bulged-G motif To Be Published 0 0 0 0 7EEN Bulged-G motif composed of RNA, DNA and 2'-O-methyl RNA 2021-03-19 2022-03-23 Kondo, J.,Sekiguchi, S. Bulged-G motif composed of RNA, DNA and 2'-O-methyl RNA To Be Published 0 0 0 0 7EEO Bulged-G motif composed of RNA, DNA and 2'-O-methyl RNA 2021-03-19 2022-03-23 Kondo, J.,Sekiguchi, S. Bulged-G motif composed of RNA, DNA and 2'-O-methyl RNA To Be Published 0 0 0 0 7EFH RNA kink-turn motif 2021-03-21 2022-03-23 Kondo, J.,Nagashima, M. RNA kink-turn motif To Be Published 0 0 0 0 7FHS 34742017 Crystal structure of DYRK1A in complex with RD0392 2021-07-30 2022-03-23 Miyazaki, Y.,Kikuchi, M.,Umezawa, K.,Descamps, A.,Nakamura, D.,Furuie, G.,Sumida, T.,Saito, K.,Kimura, N.,Niwa, T.,Sumida, Y.,Umehara, T.,Hosoya, T.,Kii, I. Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A. Eur.J.Med.Chem. 2022 227 113948 113948 7FHT 34742017 Crystal structure of DYRK1A in complex with RD0448 2021-07-30 2022-03-23 Miyazaki, Y.,Kikuchi, M.,Umezawa, K.,Descamps, A.,Nakamura, D.,Furuie, G.,Sumida, T.,Saito, K.,Kimura, N.,Niwa, T.,Sumida, Y.,Umehara, T.,Hosoya, T.,Kii, I. Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A. Eur.J.Med.Chem. 2022 227 113948 113948 7M3V RNA bulged-G motif 2021-03-19 2022-03-23 Kondo, J.,Sekiguchi, S. RNA bulged-G motif To Be Published 0 0 0 0 7EFI RNA kink-turn motif composed of RNA, DNA and 2'-O-methyl RNA 2021-03-21 2022-03-30 Kondo, J.,Nagashima, M. RNA kink-turn motif composed of RNA, DNA and 2'-O-methyl RNA To Be Published 0 0 0 0 7EI6 GNRA tetraloop receptor motif composed of RNA and DNA 2021-03-30 2022-03-30 Kondo, J.,Hayasaka, A. RNA GNRA tetraloop and tetraloop receptor motifs To Be Published 0 0 0 0 7EI9 RNA kink-turn motif with pyrrolo cytosine 2021-03-30 2022-03-30 Kondo, J.,Miyauchi, T. RNA kink-turn motif with pyrrolo cytosine To Be Published 0 0 0 0 7EIA RNA kink-turn motif with pyrrolo cytosine 2021-03-30 2022-03-30 Kondo, J.,Miyauchi, T. RNA kink-turn motif with pyrrolo cytosine To Be Published 0 0 0 0 7EM4 35504278 Crystal structure of the PI5P4Kbeta F205L-ITP complex 2021-04-13 2022-03-30 Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T. The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure 2022 30 886 0 7EM5 35504278 Crystal structure of the PI5P4Kbeta F205L-XTP complex 2021-04-13 2022-03-30 Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T. The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure 2022 30 886 0 7EM6 35504278 Crystal structure of the PI5P4Kbeta N203D-ITP complex 2021-04-13 2022-03-30 Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T. The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure 2022 30 886 0 7EM8 35504278 Crystal structure of the PI5P4Kbeta T201M-2a-ATP complex 2021-04-13 2022-03-30 Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T. The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure 2022 30 886 0 7VMC 35411396 Crystal structure of EF-Tu/CdiA/CdiI 2021-10-08 2022-03-30 Wang, J.,Yashiro, Y.,Sakaguchi, Y.,Suzuki, T.,Tomita, K. Mechanistic insights into tRNA cleavage by a contact-dependent growth inhibitor protein and translation factors. Nucleic Acids Res. 2022 50 4713 4731 7EFG RNA kink-turn motif 2021-03-21 2022-04-13 Kondo, J.,Nagashima, M. RNA kink-turn motif To Be Published 0 0 0 0 7FI3 35170084 Archaeal oligopeptide permease A (OppA) from Thermococcus kodakaraensis in complex with an endogenous pentapeptide 2021-07-30 2022-04-13 Yokoyama, H.,Kamei, N.,Konishi, K.,Hara, K.,Ishikawa, Y.,Matsui, I.,Forterre, P.,Hashimoto, H. Structural basis for peptide recognition by archaeal oligopeptide permease A. Proteins 2022 90 1434 1442 7WSZ 35363883 human glyoxalase I (with C-ter His tag) in glycerol-bound form 2022-02-03 2022-04-13 Usami, M.,Ando, K.,Shibuya, A.,Takasawa, R.,Yokoyama, H. Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett. 2022 596 1458 1467 7WT0 35363883 human glyoxalase I (with C-ter His tag) in complex with TLSC702 2022-02-03 2022-04-13 Usami, M.,Ando, K.,Shibuya, A.,Takasawa, R.,Yokoyama, H. Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett. 2022 596 1458 1467 7WT1 35363883 human glyoxalase I (with C-ter His tag) in inhibitor-free form 2022-02-03 2022-04-13 Usami, M.,Ando, K.,Shibuya, A.,Takasawa, R.,Yokoyama, H. Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett. 2022 596 1458 1467 7WT2 35363883 human glyoxalase I in complex with TLSC702 2022-02-03 2022-04-13 Usami, M.,Ando, K.,Shibuya, A.,Takasawa, R.,Yokoyama, H. Crystal structures of human glyoxalase I and its complex with TLSC702 reveal inhibitor binding mode and substrate preference. Febs Lett. 2022 596 1458 1467 7X0C 35408716 Crystal structure of phospholipase A1, AtDSEL 2022-02-21 2022-04-13 Heo, Y.,Lee, I.,Moon, S.,Yun, J.H.,Kim, E.Y.,Park, S.Y.,Park, J.H.,Kim, W.T.,Lee, W. Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain. Molecules 2022 27 0 0 7X0D 35408716 Crystal structure of phospholipase A1, CaPLA1 2022-02-21 2022-04-13 Heo, Y.,Lee, I.,Moon, S.,Yun, J.H.,Kim, E.Y.,Park, S.Y.,Park, J.H.,Kim, W.T.,Lee, W. Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain. Molecules 2022 27 0 0 7F1P 34953671 Crystal structure of Pseudomonas putida methionine gamma-lyase Q349S mutant ligand-free form. 2021-06-09 2022-04-20 Okawa, A.,Handa, H.,Yasuda, E.,Murota, M.,Kudo, D.,Tamura, T.,Shiba, T.,Inagaki, K. Characterization and application of l-methionine gamma-lyase Q349S mutant enzyme with an enhanced activity toward l-homocysteine. J.Biosci.Bioeng. 2022 133 213 221 7XGC Crystal structure of influenza polymerase acidic subunit N-terminal domain crystallized by ammonium sulfate with glycan 2022-04-04 2022-04-20 Guo, Y.,Hoshino, T. Influence of Glycan Agents on Protein Crystallization with Ammonium Sulfate Cryst.Growth Des. 2022 0 0 0 7XGQ Crystal structure of chitosanase crystallized by ammonium sulfate with glycan 2022-04-05 2022-04-20 Guo, Y.,Hoshino, T. Influence of Glycan Agents on Protein Crystallization with Ammonium Sulfate Cryst.Growth Des. 2022 0 0 0 7XJ4 36184946 Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester 2022-04-15 2022-04-27 Lu, H.,Komukai, Y.,Usami, K.,Guo, Y.,Qiao, X.,Nukaga, M.,Hoshino, T. Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity. J.Chem.Inf.Model. 2022 62 6762 6774 7VNV 35477761 Crystal Structure of tRNAVal from Sulfolobus Tokodaii 2021-10-12 2022-05-04 Ohira, T.,Minowa, K.,Sugiyama, K.,Yamashita, S.,Sakaguchi, Y.,Miyauchi, K.,Noguchi, R.,Kaneko, A.,Orita, I.,Fukui, T.,Tomita, K.,Suzuki, T. Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance. Nature 2022 605 372 379 7VNW 35477761 Crystal Structure of tRNAVal from Sulfolobus Tokodaii(Dephosphorylated) 2021-10-12 2022-05-04 Ohira, T.,Minowa, K.,Sugiyama, K.,Yamashita, S.,Sakaguchi, Y.,Miyauchi, K.,Noguchi, R.,Kaneko, A.,Orita, I.,Fukui, T.,Tomita, K.,Suzuki, T. Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance. Nature 2022 605 372 379 7VNX 35477761 Crystal structure of TkArkI 2021-10-12 2022-05-04 Ohira, T.,Minowa, K.,Sugiyama, K.,Yamashita, S.,Sakaguchi, Y.,Miyauchi, K.,Noguchi, R.,Kaneko, A.,Orita, I.,Fukui, T.,Tomita, K.,Suzuki, T. Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance. Nature 2022 605 372 379 7WGL 35563117 X-ray structure of human PPAR delta ligand binding domain-bezafibrate co-crystals obtained by co-crystallization 2021-12-28 2022-05-25 Honda, A.,Kamata, S.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Habu, Y.,Miyawaki, S.,Kaneko, C.,Oyama, T.,Ishii, I. Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. Int J Mol Sci 2022 23 0 0 7WGP 35563117 X-ray structure of human PPAR gamma ligand binding domain-fenofibric acid co-crystals obtained by co-crystallization 2021-12-28 2022-05-25 Honda, A.,Kamata, S.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Habu, Y.,Miyawaki, S.,Kaneko, C.,Oyama, T.,Ishii, I. Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. Int J Mol Sci 2022 23 0 0 7V62 35613096 Crystal structure of human OSBP ORD in complex with cholesterol 2021-08-19 2022-06-08 Kobayashi, J.,Arita, M.,Sakai, S.,Kojima, H.,Senda, M.,Senda, T.,Hanada, K.,Kato, R. Ligand Recognition by the Lipid Transfer Domain of Human OSBP Is Important for Enterovirus Replication. Acs Infect Dis. 2022 8 1161 1170 7VW7 35912346 Crystal structure of the 2 ADP-AlF4-bound V1 complex 2021-11-09 2022-06-22 Shekhar, M.,Gupta, C.,Suzuki, K.,Chan, C.K.,Murata, T.,Singharoy, A. Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations. Acs Cent.Sci. 2022 8 915 925 7F4Z X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with ADP 2021-06-21 2022-06-29 Yokoyama, T.,Fujii, S.,Ostermann, A.,Schrader, T.E.,Nabeshima, Y.,Mizuguchi, M. Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj 2022 9 562 572 7F50 X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with AMPPnP 2021-06-21 2022-06-29 Yokoyama, T.,Fujii, S.,Ostermann, A.,Schrader, T.E.,Nabeshima, Y.,Mizuguchi, M. Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj 2022 9 562 572 7F8Z RNA kink-turn motif with 2-aminopurine 2021-07-03 2022-07-06 Kondo, J.,Miyauchi, T. RNA kink-turn motif with 2-aminopurine To Be Published 0 0 0 0 7XLV 36132821 Crystal structure of a NIR-emitting DNA-stabilized Ag16 nanocluster (G7I mutant) 2022-04-23 2022-07-13 Cerretani, C.,Liisberg, M.B.,Ruck, V.,Kondo, J.,Vosch, T. The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster. Nanoscale Adv 2022 4 3212 3217 7XLW 36132821 Crystal structure of a NIR-emitting DNA-stabilized Ag16 nanocluster (G7I/G9I mutant) 2022-04-23 2022-07-13 Cerretani, C.,Liisberg, M.B.,Ruck, V.,Kondo, J.,Vosch, T. The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster. Nanoscale Adv 2022 4 3212 3217 7XVZ 35810932 Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-3-(2-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propanenitrile 2022-05-25 2022-07-20 Handa, C.,Yamazaki, Y.,Yonekubo, S.,Furuya, N.,Momose, T.,Ozawa, T.,Furuishi, T.,Fukuzawa, K.,Yonemochi, E. Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with diarylpropionitrile (DPN) or DPN derivatives. J.Steroid Biochem.Mol.Biol. 2022 222 106152 106152 7XWP 35810932 Human Estrogen Receptor beta Ligand-binding Domain in Complex with (S)-3-(2-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propanenitrile 2022-05-27 2022-07-20 Handa, C.,Yamazaki, Y.,Yonekubo, S.,Furuya, N.,Momose, T.,Ozawa, T.,Furuishi, T.,Fukuzawa, K.,Yonemochi, E. Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with diarylpropionitrile (DPN) or DPN derivatives. J.Steroid Biochem.Mol.Biol. 2022 222 106152 106152 7XWQ 35810932 Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-2-(2-chloro-4-hydroxyphenyl)-3-(4-hydroxyphenyl)propanenitrile 2022-05-27 2022-07-20 Handa, C.,Yamazaki, Y.,Yonekubo, S.,Furuya, N.,Momose, T.,Ozawa, T.,Furuishi, T.,Fukuzawa, K.,Yonemochi, E. Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with diarylpropionitrile (DPN) or DPN derivatives. J.Steroid Biochem.Mol.Biol. 2022 222 106152 106152 7XWR 35810932 Human Estrogen Receptor beta Ligand-binding Domain in Complex with (S)-2-(2-chloro-4-hydroxyphenyl)-3-(4-hydroxyphenyl)propanenitrile 2022-05-27 2022-07-20 Handa, C.,Yamazaki, Y.,Yonekubo, S.,Furuya, N.,Momose, T.,Ozawa, T.,Furuishi, T.,Fukuzawa, K.,Yonemochi, E. Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with diarylpropionitrile (DPN) or DPN derivatives. J.Steroid Biochem.Mol.Biol. 2022 222 106152 106152 7FFX The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with alpha-llinolenic acid 2021-07-24 2022-07-27 Sugiyama, S.,Matsuoka, S.,Tsuchikawa, H.,Sonoyama, M.,Inoue, Y.,Hayashi, F.,Murata, M. The 0.88 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with alpha-llinolenic acid To Be Published 0 0 0 0 7FH2 34757034 Crystal structure of the first bromodomain of BRD4 in complex with 16D10 2021-07-29 2022-08-03 Segawa, R.,Takeda, H.,Yokoyama, T.,Ishida, M.,Miyata, C.,Saito, T.,Ishihara, R.,Nakagita, T.,Sasano, Y.,Kanoh, N.,Iwabuchi, Y.,Mizuguchi, M.,Hiratsuka, M.,Hirasawa, N. A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins. Biochem Pharmacol 2021 194 114819 114819 7FA1 35729072 Crystal Structure of N-terminus of the non-structural protein 2 from SARS coronavirus 2021-07-05 2022-08-10 Lou, Z.,Rao, Z. The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function. Annu.Rev.Biochem. 2022 91 381 401 7FAC 35729072 Crystal Structure of C-terminus of the non-structural protein 2 from SARS coronavirus 2021-07-06 2022-08-10 Lou, Z.,Rao, Z. The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function. Annu.Rev.Biochem. 2022 91 381 401 7V8Y 36161947 Crystal structure of mouse CRY2 in complex with SHP1703 compound 2021-08-23 2022-08-24 Miller, S.,Kesherwani, M.,Chan, P.,Nagai, Y.,Yagi, M.,Cope, J.,Tama, F.,Kay, S.A.,Hirota, T. CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7V8Z 36161947 Crystal structure of mouse CRY2 in complex with SHP656 compound 2021-08-23 2022-08-24 Miller, S.,Kesherwani, M.,Chan, P.,Nagai, Y.,Yagi, M.,Cope, J.,Tama, F.,Kay, S.A.,Hirota, T. CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc.Natl.Acad.Sci.USA 2022 119 0 0 7W70 36001659 Crystal structure of the PDZ-C domain fragment of Kangiella koreensis RseP orthologue 2021-12-02 2022-09-07 Imaizumi, Y.,Takanuki, K.,Miyake, T.,Takemoto, M.,Hirata, K.,Hirose, M.,Oi, R.,Kobayashi, T.,Miyoshi, K.,Aruga, R.,Yokoyama, T.,Katagiri, S.,Matsuura, H.,Iwasaki, K.,Kato, T.,Kaneko, M.K.,Kato, Y.,Tajiri, M.,Akashi, S.,Nureki, O.,Hizukuri, Y.,Akiyama, Y.,Nogi, T. Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP. Sci Adv 2022 8 0 0 7W71 36001659 Crystal structure of the PDZ-C domain of E. coli RseP in complex with 12C7 Fab 2021-12-02 2022-09-07 Imaizumi, Y.,Takanuki, K.,Miyake, T.,Takemoto, M.,Hirata, K.,Hirose, M.,Oi, R.,Kobayashi, T.,Miyoshi, K.,Aruga, R.,Yokoyama, T.,Katagiri, S.,Matsuura, H.,Iwasaki, K.,Kato, T.,Kaneko, M.K.,Kato, Y.,Tajiri, M.,Akashi, S.,Nureki, O.,Hizukuri, Y.,Akiyama, Y.,Nogi, T. Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP. Sci Adv 2022 8 0 0 7WUW 35998388 Crystal structure of AziU3/U2 from Streptomyces sahachiroi 2022-02-09 2022-09-07 Kurosawa, S.,Hasebe, F.,Okamura, H.,Yoshida, A.,Matsuda, K.,Sone, Y.,Tomita, T.,Shinada, T.,Takikawa, H.,Kuzuyama, T.,Kosono, S.,Nishiyama, M. Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination. J.Am.Chem.Soc. 2022 144 16164 16170 7VFQ Wild type GltA from Bifidobacterium infantis JCM 1222 complexed with lacto-N-tetraose 2021-09-13 2022-09-14 Sakanaka, M.,Sato, M.,Fushinobu, S.,Katayama, T. Short stretch sequence of a milk oligosaccharide transporter represents the phenotypic selection trajectory in infant gut microbiome To Be Published 0 0 0 0 7VFR GltA N83K mutant from Bifidobacterium infantis JCM 1222 complexed with lacto-N-tetraose 2021-09-13 2022-09-14 Sakanaka, M.,Sato, M.,Fushinobu, S.,Katayama, T. Short stretch sequence of a milk oligosaccharide transporter represents the phenotypic selection trajectory in infant gut microbiome To Be Published 0 0 0 0 7XWA 36198317 Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.4/5 variant spike protein in complex with its receptor ACE2 2022-05-26 2022-09-28 Kimura, I.,Yamasoba, D.,Tamura, T.,Nao, N.,Suzuki, T.,Oda, Y.,Mitoma, S.,Ito, J.,Nasser, H.,Zahradnik, J.,Uriu, K.,Fujita, S.,Kosugi, Y.,Wang, L.,Tsuda, M.,Kishimoto, M.,Ito, H.,Suzuki, R.,Shimizu, R.,Begum, M.M.,Yoshimatsu, K.,Kimura, K.T.,Sasaki, J.,Sasaki-Tabata, K.,Yamamoto, Y.,Nagamoto, T.,Kanamune, J.,Kobiyama, K.,Asakura, H.,Nagashima, M.,Sadamasu, K.,Yoshimura, K.,Shirakawa, K.,Takaori-Kondo, A.,Kuramochi, J.,Schreiber, G.,Ishii, K.J.,Hashiguchi, T.,Ikeda, T.,Saito, A.,Fukuhara, T.,Tanaka, S.,Matsuno, K.,Sato, K. Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5. Cell 2022 185 3992 0 7VU9 36007953 Pholiota squarrosa lectin (PhoSL) in complex with fucose(alpha1-6)[GlcNAc(beta1-4)]GlcNAc 2021-11-01 2022-10-12 Yamasaki, K.,Adachi, N.,Ngwe Tun, M.M.,Ikeda, A.,Moriya, T.,Kawasaki, M.,Yamasaki, T.,Kubota, T.,Nagashima, I.,Shimizu, H.,Tateno, H.,Morita, K. Core fucose-specific Pholiota squarrosa lectin (PhoSL) as a potent broad-spectrum inhibitor of SARS-CoV-2 infection. Febs J. 2023 290 412 427 7YVX Left-handed DNA duplex containing consecutive G-G base pairs 2022-08-19 2022-10-12 Kondo, J. Left-handed DNA duplex containing consecutive G-G base pairs To Be Published 0 0 0 0 7Y4O 36156831 Rat Semaphorin 6D extracellular region 2022-06-15 2022-10-19 Tanaka, T.,Ekimoto, T.,Nagatomo, M.,Neyazaki, M.,Shimoji, E.,Yamane, T.,Kanagawa, S.,Oi, R.,Mihara, E.,Takagi, J.,Akashi, S.,Ikeguchi, M.,Nogi, T. Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D. Protein Sci. 2022 31 0 0 7Y4P 36156831 Human Plexin A1, extracellular domains 1-4 2022-06-15 2022-10-19 Tanaka, T.,Ekimoto, T.,Nagatomo, M.,Neyazaki, M.,Shimoji, E.,Yamane, T.,Kanagawa, S.,Oi, R.,Mihara, E.,Takagi, J.,Akashi, S.,Ikeguchi, M.,Nogi, T. Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D. Protein Sci. 2022 31 0 0 7Y4Q 36156831 Semaphorin 6D in complex with Plexin A1 2022-06-16 2022-10-19 Tanaka, T.,Ekimoto, T.,Nagatomo, M.,Neyazaki, M.,Shimoji, E.,Yamane, T.,Kanagawa, S.,Oi, R.,Mihara, E.,Takagi, J.,Akashi, S.,Ikeguchi, M.,Nogi, T. Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D. Protein Sci. 2022 31 0 0 7X5E 36454022 Nrf2-MafG heterodimer bound with CsMBE1 2022-03-04 2022-11-09 Sengoku, T.,Shiina, M.,Suzuki, K.,Hamada, K.,Sato, K.,Uchiyama, A.,Kobayashi, S.,Oguni, A.,Itaya, H.,Kasahara, K.,Moriwaki, H.,Watanabe, C.,Honma, T.,Okada, C.,Baba, S.,Ohta, T.,Motohashi, H.,Yamamoto, M.,Ogata, K. Structural basis of transcription regulation by CNC family transcription factor, Nrf2. Nucleic Acids Res. 2022 50 12543 12557 7VZP FAD-dpendent Glucose Dehydrogenase from Aspergillus oryzae 2021-11-16 2022-11-16 Nakajima, Y. Conformational change of catalytic residue in reduced enzyme of FAD-dependent Glucose Dehydrogenase at pH6.5 To Be Published 0 0 0 0 7XY8 Crystal structure of antibody Fab fragment in complex with CD147(EMMPIRIN) 2022-06-01 2022-11-23 Qin, S.,Fukuchi, K.,Nanai, K.,Yuita, H.,Maru, C.,Tsukada, J.,Ishigami, M.,Nagai, Y.,Nakano, Y.,Yoshimura, C.,Yoneda, K.,Amano, M.,Nakamura, K.,Oda, Y.,Nishigohri, H.,Yamamoto, S.,Ohnishi-Totoki, Y.,Inaki, K.,Komori, H.,Nakano, R.,Kanari, Y.,Nishida, A.,Matsui, Y.,Funo, S.,Takahashi, S.,Ohtsuka, T.,Agatsuma, T. Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals J Oncol 2022 2022 3552793 0 8GN9 36386441 SPFH domain of Pyrococcus horikoshii stomatin 2022-08-23 2022-12-07 Komatsu, T.,Matsui, I.,Yokoyama, H. Structural and mutational studies suggest key residues to determine whether stomatin SPFH domains form dimers or trimers. Biochem Biophys Rep 2022 32 101384 101384 7W86 36342219 Crystal structure of the DYW domain of DYW1 2021-12-07 2022-12-14 Toma-Fukai, S.,Sawada, Y.,Maeda, A.,Shimizu, H.,Shikanai, T.,Takenaka, M.,Shimizu, T. Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation. Plant Cell 2023 35 1888 1900 7W9Q 36472374 Crystal structure of V30M-TTR in complex with naringenin derivative-14 2021-12-10 2022-12-14 Mizuguchi, M.,Nakagawa, Y.,Inui, K.,Katayama, W.,Sawai, Y.,Shimane, A.,Kitakami, R.,Okada, T.,Nabeshima, Y.,Yokoyama, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N. Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem. 2022 65 16218 16233 7W9R 36472374 Crystal structure of V30M-TTR in complex with naringenin derivative-18 2021-12-10 2022-12-14 Mizuguchi, M.,Nakagawa, Y.,Inui, K.,Katayama, W.,Sawai, Y.,Shimane, A.,Kitakami, R.,Okada, T.,Nabeshima, Y.,Yokoyama, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N. Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem. 2022 65 16218 16233 8HKW 36875212 Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal 2022-11-28 2022-12-21 Matsuura, Y. Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal. Data Brief 2023 47 108988 108988 7WKZ 36538495 Crystal structure of the HSA complex with mycophenolate and aripiprazole 2022-01-12 2022-12-28 Yamasaki, K.,Teshima, H.,Yukizawa, R.,Kuyama, K.,Tsukigawa, K.,Nishi, K.,Otagiri, M.,Kawai, A. Structural Basis of the Change in the Interaction Between Mycophenolic Acid and Subdomain IIA of Human Serum Albumin During Renal Failure. J.Med.Chem. 2023 66 951 961 7YK9 36463961 Neutron Structure of PcyA I86D Mutant Complexed with Biliverdin at Room Temperature 2022-07-22 2023-01-25 Joutsuka, T.,Nanasawa, R.,Igarashi, K.,Horie, K.,Sugishima, M.,Hagiwara, Y.,Wada, K.,Fukuyama, K.,Yano, N.,Mori, S.,Ostermann, A.,Kusaka, K.,Unno, M. Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states. J.Biol.Chem. 2022 299 102763 102763 7YK9 36463961 Neutron Structure of PcyA I86D Mutant Complexed with Biliverdin at Room Temperature 2022-07-22 2023-01-25 Joutsuka, T.,Nanasawa, R.,Igarashi, K.,Horie, K.,Sugishima, M.,Hagiwara, Y.,Wada, K.,Fukuyama, K.,Yano, N.,Mori, S.,Ostermann, A.,Kusaka, K.,Unno, M. Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states. J.Biol.Chem. 2022 299 102763 102763 7WSX 37709776 Class III hybrid cluster protein (HCP) C67Y variant from Methanothermobacter marburgensis 2022-02-02 2023-02-08 Fujishiro, T.,Takaoka, K. Class III hybrid cluster protein homodimeric architecture shows evolutionary relationship with Ni, Fe-carbon monoxide dehydrogenases. Nat Commun 2023 14 5609 5609 8HE0 36806083 Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type) 2022-11-07 2023-02-22 Matsuura, Y.,Miyawaki, K. Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun. 2023 652 1 5 8HE3 36806083 Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751) 2022-11-07 2023-02-22 Matsuura, Y.,Miyawaki, K. Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun. 2023 652 1 5 7YU0 36799721 Structure of 6-aminohexanoate-oligomer hydrolase NylC precursor, H130Y/N266A/T267A mutant 2022-08-16 2023-03-01 Negoro, S.,Shibata, N.,Kato, D.I.,Tanaka, Y.,Yasuhira, K.,Nagai, K.,Oshima, S.,Furuno, Y.,Yokoyama, R.,Miyazaki, K.,Takeo, M.,Hengphasatporn, K.,Shigeta, Y.,Lee, Y.H.,Higuchi, Y. X-ray crystallographic and mutational analysis of the NylC precursor: catalytic mechanism of autocleavage and substrate hydrolysis of nylon hydrolase. Febs J. 2023 290 3400 3421 8GNN 36841485 Crystal structure of the human RAD9-RAD1-HUS1-RAD17 complex 2022-08-24 2023-03-08 Hara, K.,Hishiki, A.,Hoshino, T.,Nagata, K.,Iida, N.,Sawada, Y.,Ohashi, E.,Hashimoto, H. The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO. J.Biol.Chem. 2023 299 103061 103061 8HFH 36823439 CENP-E motor domain in complex with AMPPNP and Mg2+ 2022-11-10 2023-03-08 Shibuya, A.,Suzuki, A.,Ogo, N.,Sawada, J.I.,Asai, A.,Yokoyama, H. Crystal structure of the motor domain of centromere-associated protein E in complex with a non-hydrolysable ATP analogue. Febs Lett. 2023 597 1138 1148 8IBL MES bound form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H and S176A inactivation 2023-02-10 2023-03-15 Numoto, N.,Kamiya, N.,Oda, M. Improvement of thermostability and activity of PET-degrading enzyme Cut190 towards a detailed understanding and application of the enzymatic reaction mechanism. Biorxiv 2023 0 0 0 8IBM Sulfate bound form of PET-degrading cutinase Cut190 with thermostability-improving mutations of S226P/R228S/Q138A/D250C-E296C/Q123H/N202H and S176A inactivation 2023-02-10 2023-03-15 Numoto, N.,Kamiya, N.,Oda, M. Improvement of thermostability and activity of PET-degrading enzyme Cut190 towards a detailed understanding and application of the enzymatic reaction mechanism. Biorxiv 2023 0 0 0 8I8T 36914375 Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dAMP and Mn2+ 2023-02-05 2023-03-22 Nakamura, T.,Koga-Ogawa, Y.,Fujimiya, K.,Chirifu, M.,Goto, M.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y. Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. Febs Lett. 2023 597 1770 1778 7XEJ SufS with D-cysteine for 5 min 2022-03-31 2023-04-05 Nakamura, R.,Takahashi, Y.,Fujishiro, T. X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine to be published 0 0 0 0 7XMH 36328178 Crystal structure of a rice class IIIb chitinase, Oschib2 2022-04-25 2023-05-03 Tanaka, J.,Takashima, T.,Abe, N.,Fukamizo, T.,Numata, T.,Ohnuma, T. Characterization of two rice GH18 chitinases belonging to family 8 of plant pathogenesis-related proteins. Plant Sci. 2023 326 111524 111524 7YRK 37106030 Crystal structure of the hen egg lysozyme-2-oxidobenzylidene-threoninato-copper (II) complex 2022-08-10 2023-05-10 Furuya, T.,Nakane, D.,Kitanishi, K.,Katsuumi, N.,Tsaturyan, A.,Shcherbakov, I.N.,Unno, M.,Akitsu, T. A novel hybrid protein composed of superoxide-dismutase-active Cu(II) complex and lysozyme. Sci Rep 2023 13 6892 6892 7YGP 36716510 DNA duplex containing 5OHU-T base pairs 2022-07-12 2023-05-24 Torigoe, H.,Kondo, J.,Arakawa, F. Specific binding of Hg 2+ to mismatched base pairs involving 5-hydroxyuracil in duplex DNA. J.Inorg.Biochem. 2023 241 112125 112125 8IE2 37261968 Crystal structure of Lactiplantibacillus plantarum GlyRS 2023-02-15 2023-06-07 Nagato, Y.,Yamashita, S.,Ohashi, A.,Furukawa, H.,Takai, K.,Tomita, K.,Tomikawa, C. Mechanism of tRNA recognition by heterotetrameric glycyl-tRNA synthetase from lactic acid bacteria. J.Biochem. 2023 174 291 303 8J6V Structure of yeast Arginyl-tRNA-protein transferase 1 2023-04-26 2023-06-07 Yashiro, Y.,Tomita, T. Structure of Arginyl-tRNA-protein transferase 1 To Be Published 0 0 0 0 8I2Q 37280168 Beijerinckia indica beta-fructosyltransferase variant H395R/F473Y 2023-01-15 2023-06-14 Li, D.,Miyasaka, Y.,Kubota, A.,Kozono, T.,Kitano, Y.,Sasaki, N.,Fujii, T.,Tochio, T.,Kadota, Y.,Nishikawa, A.,Tonozuka, T. Characterization and alteration of product specificity of Beijerinckia indica subsp. indica beta-fructosyltransferase. Biosci.Biotechnol.Biochem. 2023 87 981 990 8I2R 37280168 Beijerinckia indica beta-fructosyltransferase variant H395R/F473Y in complex with fructose 2023-01-15 2023-06-14 Li, D.,Miyasaka, Y.,Kubota, A.,Kozono, T.,Kitano, Y.,Sasaki, N.,Fujii, T.,Tochio, T.,Kadota, Y.,Nishikawa, A.,Tonozuka, T. Characterization and alteration of product specificity of Beijerinckia indica subsp. indica beta-fructosyltransferase. Biosci.Biotechnol.Biochem. 2023 87 981 990 8II2 37311373 Crystal structure of V30M-TTR in complex with BBM 2023-02-24 2023-06-28 Mizuguchi, M.,Yokoyama, T.,Okada, T.,Nakagawa, Y.,Fujii, K.,Nabeshima, Y.,Toyooka, N. Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem. 2023 90 117370 117370 8II3 37311373 Crystal structure of V30M-TTR in complex with 6-hydroxy BID 2023-02-24 2023-06-28 Mizuguchi, M.,Yokoyama, T.,Okada, T.,Nakagawa, Y.,Fujii, K.,Nabeshima, Y.,Toyooka, N. Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem. 2023 90 117370 117370 8II4 37311373 Crystal structure of V30M-TTR in complex with 6-hydroxy BBM 2023-02-24 2023-06-28 Mizuguchi, M.,Yokoyama, T.,Okada, T.,Nakagawa, Y.,Fujii, K.,Nabeshima, Y.,Toyooka, N. Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis. Bioorg.Med.Chem. 2023 90 117370 117370 7YB3 SufS with D-cysteine for 1 min 2022-06-28 2023-07-05 Nakamura, R.,Takahashi, Y.,Fujishiro, T. Snapshots of thiazolidine fomration of PLP-dependent enzyme SufS to be published 0 0 0 0 8I60 37311463 Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr 2023-01-26 2023-07-26 Liu, N.,Konuma, T.,Sharma, R.,Wang, D.,Zhao, N.,Cao, L.,Ju, Y.,Liu, D.,Wang, S.,Bosch, A.,Sun, Y.,Zhang, S.,Ji, D.,Nagatoishi, S.,Suzuki, N.,Kikuchi, M.,Wakamori, M.,Zhao, C.,Ren, C.,Zhou, T.J.,Xu, Y.,Meslamani, J.,Fu, S.,Umehara, T.,Tsumoto, K.,Akashi, S.,Zeng, L.,Roeder, R.G.,Walsh, M.J.,Zhang, Q.,Zhou, M.M. Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Mol.Cell 2023 83 2206 0 8IB1 37556494 Structure of the LAH31 Fab bound to an influenza virus HA epitope peptide 2023-02-09 2023-07-26 Tonouchi, K.,Adachi, Y.,Suzuki, T.,Kuroda, D.,Nishiyama, A.,Yumoto, K.,Takeyama, H.,Suzuki, T.,Hashiguchi, T.,Takahashi, Y. Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope. Plos Pathog. 2023 19 0 0 8H4V 37521780 Mincle CRD complex with PGL trisaccharide 2022-10-11 2023-08-09 Ishizuka, S.,van Dijk, J.H.M.,Kawakita, T.,Miyamoto, Y.,Maeda, Y.,Goto, M.,Le Calvez, G.,Groot, L.M.,Witte, M.D.,Minnaard, A.J.,van der Marel, G.A.,Ato, M.,Nagae, M.,Codee, J.D.C.,Yamasaki, S. PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand. Acs Cent.Sci. 2023 9 1388 1399 8HB5 37521780 Crystal structure of Mincle in complex with HD-275 2022-10-27 2023-08-09 Ishizuka, S.,van Dijk, J.H.M.,Kawakita, T.,Miyamoto, Y.,Maeda, Y.,Goto, M.,Le Calvez, G.,Groot, L.M.,Witte, M.D.,Minnaard, A.J.,van der Marel, G.A.,Ato, M.,Nagae, M.,Codee, J.D.C.,Yamasaki, S. PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand. Acs Cent.Sci. 2023 9 1388 1399 8HUK 37627519 X-ray structure of human PPAR alpha ligand binding domain-lanifibranor-SRC1 coactivator peptide co-crystals obtained by soaking 2022-12-24 2023-08-09 Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants 2023 12 0 0 8HUL 37627519 X-ray structure of human PPAR delta ligand binding domain-lanifibranor co-crystals obtained by co-crystallization 2022-12-24 2023-08-09 Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants 2023 12 0 0 8HUO 37627519 X-ray structure of human PPAR delta ligand binding domain-seladelpar co-crystals obtained by co-crystallization 2022-12-24 2023-08-09 Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants 2023 12 0 0 8HUP 37627519 X-ray structure of human PPAR gamma ligand binding domain-seladelpar-SRC1 coactivator peptide co-crystals obtained by co-crystallization 2022-12-24 2023-08-09 Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants 2023 12 0 0 8HUQ 37627519 X-ray structure of human PPAR alpha ligand binding domain-elafibranor-SRC1 coactivator peptide co-crystals obtained by soaking 2022-12-24 2023-08-09 Kamata, S.,Honda, A.,Ishikawa, R.,Akahane, M.,Fujita, A.,Kaneko, C.,Miyawaki, S.,Habu, Y.,Shiiyama, Y.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. Functional and Structural Insights into the Human PPAR alpha / delta / gamma Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants 2023 12 0 0 8IDF 37563152 Crystal structure of human TUT1 complexed with U6 snRNA 2023-02-13 2023-08-09 Yamashita, S.,Tomita, K. Mechanism of U6 snRNA oligouridylation by human TUT1. Nat Commun 2023 14 4686 4686 7YRI S-adenosylmethionine sensor upstream of mTORC1 2022-08-10 2023-08-16 Zhang, H.,Li, X.Z.,Wen, Y.N. S-adenosylmethionine sensor upstream of mTORC1 To Be Published 0 0 0 0 8H1Q 37030501 Serine Palmitoyltransferase from Sphingobacterium multivorum complexed with L-serine 2022-10-03 2023-08-16 Ikushiro, H.,Murakami, T.,Takahashi, A.,Katayama, A.,Sawai, T.,Goto, H.,Koolath, S.,Murai, Y.,Monde, K.,Miyahara, I.,Kamiya, N.,Yano, T. Structural insights into the substrate recognition of serine palmitoyltransferase from Sphingobacterium multivorum. J.Biol.Chem. 2023 299 104684 104684 8H20 37030501 Serine Palmitoyltransferase from Sphingobacterium multivorum complexed with Glycine 2022-10-04 2023-08-16 Ikushiro, H.,Murakami, T.,Takahashi, A.,Katayama, A.,Sawai, T.,Goto, H.,Koolath, S.,Murai, Y.,Monde, K.,Miyahara, I.,Kamiya, N.,Yano, T. Structural insights into the substrate recognition of serine palmitoyltransferase from Sphingobacterium multivorum. J.Biol.Chem. 2023 299 104684 104684 8IG1 37522420 Crystal structure of wild-type transthyretin in complex with rafoxanide 2023-02-20 2023-08-16 Yokoyama, T.,Mizuguchi, M.,Nabeshima, Y.,Nakagawa, Y.,Okada, T.,Toyooka, N.,Kusaka, K. Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin. Febs J. 2023 290 5158 5170 8JYH 37874155 Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid C 2023-07-03 2023-08-16 Ito, Y.,Lu, H.,Kitajima, M.,Ishikawa, H.,Nakata, Y.,Iwatani, Y.,Hoshino, T. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod. 2023 86 2487 2495 8JYI 37874155 Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid E 2023-07-03 2023-08-16 Ito, Y.,Lu, H.,Kitajima, M.,Ishikawa, H.,Nakata, Y.,Iwatani, Y.,Hoshino, T. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod. 2023 86 2487 2495 8JYJ 37874155 Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid A 2023-07-03 2023-08-16 Ito, Y.,Lu, H.,Kitajima, M.,Ishikawa, H.,Nakata, Y.,Iwatani, Y.,Hoshino, T. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod. 2023 86 2487 2495 8HNO 37650645 Archaeal transcription factor Wild type 2022-12-08 2023-09-13 Bae, D.W.,Lee, S.H.,Park, J.H.,Son, S.Y.,Lin, Y.,Lee, J.H.,Jang, B.R.,Lee, K.H.,Lee, Y.H.,Lee, H.S.,Kang, S.G.,Kim, B.S.,Cha, S.S. An archaeal transcription factor EnfR with a novel 'eighth note' fold controls hydrogen production of a hyperthermophilic archaeon Thermococcus onnurineus NA1. Nucleic Acids Res. 2023 51 10026 10040 8HNP 37650645 Archaeal transcription factor Mutant 2022-12-08 2023-09-13 Bae, D.W.,Lee, S.H.,Park, J.H.,Son, S.Y.,Lin, Y.,Lee, J.H.,Jang, B.R.,Lee, K.H.,Lee, Y.H.,Lee, H.S.,Kang, S.G.,Kim, B.S.,Cha, S.S. An archaeal transcription factor EnfR with a novel 'eighth note' fold controls hydrogen production of a hyperthermophilic archaeon Thermococcus onnurineus NA1. Nucleic Acids Res. 2023 51 10026 10040 8J3T 37974946 Complex structure of human cytomegalovirus protease and a non-covalent small-molecule ligand 2023-04-18 2023-11-08 Yoshida, S.,Sako, Y.,Nikaido, E.,Ueda, T.,Kozono, I.,Ichihashi, Y.,Nakahashi, A.,Onishi, M.,Yamatsu, Y.,Kato, T.,Nishikawa, J.,Tachibana, Y. Peptide-to-Small Molecule: Discovery of Non-Covalent, Active-Site Inhibitors of beta-Herpesvirus Proteases. Acs Med.Chem.Lett. 2023 14 1558 1566 8W83 HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02 2023-08-31 2023-11-08 Okura, Y.,Ikawa-Teranishi, Y.,Mizoroki, A.,Takahashi, N.,Tsushima, T.,Irie, M.,Harfuddin, Z.,Miura-Okuda, M.,Ito, S.,Nakamura, G.,Takesue, H.,Ozono, Y.,Nishihara, M.,Yamada, K.,Gan, S.W.,Hayasaka, A.,Ishii, S.,Wakabayashi, T.,Muraoka, M.,Nagaya, N.,Hino, H.,Nemoto, T.,Kuramochi, T.,Torizawa, T.,Shimada, H.,Kitazawa, T.,Okazaki, M.,Nezu, J.,Sollid, L.M.,Igawa, T. Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease Nat Commun 2023 14 8502 0 8IN3 37910430 Eisenia hydrolysis-enhancing protein from Aplysia kurodai 2023-03-08 2023-11-15 Sun, X.,Ye, Y.,Sakurai, N.,Wang, H.,Kato, K.,Yu, J.,Yuasa, K.,Tsuji, A.,Yao, M. Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity. Elife 2023 12 0 0 8W42 37910439 X-ray crystal structure of V30M-TTR in complex with resveratrol 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8W43 37910439 X-ray crystal structure of V30M-TTR in complex with piceatannol 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8W44 37910439 X-ray crystal structure of V30M-TTR in complex with oxyresveratrol 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8W45 37910439 X-ray crystal structure of V30M-TTR in complex with pinostilbene 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8W46 37910439 X-ray crystal structure of V30M-TTR in complex with pterostilbene 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8W47 37910439 X-ray crystal structure of V30M-TTR in complex with isorhapontigenin 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8W48 37910439 Neutron and X-ray joint structure of WT-TTR in complex with piceatannol 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8W48 37910439 Neutron and X-ray joint structure of WT-TTR in complex with piceatannol 2023-08-23 2023-11-22 Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem. 2023 66 15511 15523 8HMO Crystal Structure of metal-dependent hydrolase complexed with manganese from Bacillus smithii 2022-12-05 2023-12-06 Yoneda, K.,Sakuraba, H.,Ohshima, T. Crystal Structure of metal-dependent hydrolase complexed with manganese from Bacillus smithii To Be Published 0 0 0 0 8IHX X-ray crystal structure of N372D mutant of endo-1,4-beta glucanase from Eisenia fetida 2023-02-24 2023-12-06 Kuroki, C.,Hirano, Y.,Nakazawa, M.,Sakamoto, T.,Tamada, T.,Ueda, M. A single mutation Asp43Arg was increased 2.5-fold the catalytic activity and maintained the stability of cold-adapted endo-1,4-beta glucanase (Ef-EG2) from Eisenia fetida. Curr Res Biotechnol 2023 5 0 0 8IHY X-ray crystal structure of Q387E mutant of endo-1,4-beta glucanase from Eisenia fetida 2023-02-24 2023-12-06 Kuroki, C.,Hirano, Y.,Nakazawa, M.,Sakamoto, T.,Tamada, T.,Ueda, M. A single mutation Asp43Arg was increased 2.5-fold the catalytic activity and maintained the stability of cold-adapted endo-1,4-beta glucanase (Ef-EG2) from Eisenia fetida. Curr Res Biotechnol 2023 5 0 0 8JB7 38179965 Crystal structure of CMY-185 2023-05-08 2023-12-13 Kawai, A.,Shropshire, W.C.,Suzuki, M.,Borjan, J.,Aitken, S.L.,Bachman, W.C.,McElheny, C.L.,Bhatti, M.M.,Shields, R.K.,Shelburne, S.A.,Doi, Y. Structural insights into the molecular mechanism of high-level ceftazidime-avibactam resistance conferred by CMY-185. Mbio 2024 15 0 0 8JB8 38179965 Crystal structure of CMY-185 complex with ceftazidime 2023-05-08 2023-12-13 Kawai, A.,Shropshire, W.C.,Suzuki, M.,Borjan, J.,Aitken, S.L.,Bachman, W.C.,McElheny, C.L.,Bhatti, M.M.,Shields, R.K.,Shelburne, S.A.,Doi, Y. Structural insights into the molecular mechanism of high-level ceftazidime-avibactam resistance conferred by CMY-185. Mbio 2024 15 0 0 8W7D 38051581 Crystal structure of EcPPAT-FR901483 complex 2023-08-30 2023-12-13 Sato, M.,Sakano, S.,Nakahara, M.,Tamura, Y.,Hara, K.,Hashimoto, H.,Tang, Y.,Watanabe, K. Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor. J.Am.Chem.Soc. 2023 145 26883 26889 8HRZ Crystal structure of the p97-N/D1 hexamer in complex with six p47-UBX domains 2022-12-16 2023-12-20 Nguyen, T.Q.,Kang, W. Crystal structure of the p97-N/D1 hexmaer in complex with six p47-UBX domains To Be Published 0 0 0 0 8JW3 38010834 The crystal structure of the viral terpene synthase from Orpheovirus IHUMI-LCC2 2023-06-28 2023-12-20 Jung, Y.,Mitsuhashi, T.,Sato, S.,Senda, M.,Senda, T.,Fujita, M. Function and Structure of a Terpene Synthase Encoded in a Giant Virus Genome. J.Am.Chem.Soc. 2023 145 25966 25970 8I5J 37996461 Crystal structure of chitin oligosaccharide binding protein from Vibrio cholera. 2023-01-25 2024-01-03 Ohnuma, T.,Tsujii, J.,Kataoka, C.,Yoshimoto, T.,Takeshita, D.,Lampela, O.,Juffer, A.H.,Suginta, W.,Fukamizo, T. Periplasmic chitooligosaccharide-binding protein requires a three-domain organization for substrate translocation. Sci Rep 2023 13 20558 20558 8I5K 37996461 Crystal structure of chitin oligosaccharide binding protein from Vibrio cholera in complex with chitotriose. 2023-01-25 2024-01-03 Ohnuma, T.,Tsujii, J.,Kataoka, C.,Yoshimoto, T.,Takeshita, D.,Lampela, O.,Juffer, A.H.,Suginta, W.,Fukamizo, T. Periplasmic chitooligosaccharide-binding protein requires a three-domain organization for substrate translocation. Sci Rep 2023 13 20558 20558 8I58 Uroporphyrin I (UPI)-bound CfbA 2023-01-24 2024-01-31 Ogawa, S.,Hikita, M.,Fujishiro, T. Substrate selectivity of CfbA To be published 0 0 0 0 8IPC 37160213 The recombinant NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 181 and 184 2023-03-14 2024-01-31 Adachi, Y.,Kaneko, M.K.,Kato, Y.,Nogi, T. Recombinant production of antibody antigen-binding fragments with an N-terminal human growth hormone tag in mammalian cells. Protein Expr.Purif. 2023 0 106289 106289 8WU8 38354779 Crystal structure of the human RAD9-RAD1(F64A/M256A/F266A)-HUS1-RHINO(88-99) complex 2023-10-20 2024-02-14 Hara, K.,Tatsukawa, K.,Nagata, K.,Iida, N.,Hishiki, A.,Ohashi, E.,Hashimoto, H. Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO. J.Biol.Chem. 2024 300 105751 105751 8Y0S Crystal structure of metallo-beta-lactamse, IMP-1, complexed with a quinolinone-based inhibitor 2024-01-23 2024-02-14 Kamo, T.,Kuroda, K.,Nimura, S.,Guo, Y.,Kondo, S.,Nukaga, M.,Hoshino, T. Crystal structure of metallo-beta-lactamse, IMP-1, complexed with a quinolinone-based inhibitor To Be Published 0 0 0 0 8K7Y 38324037 Crystal structure of GH146 beta-L-arabinofuranosidase Bll3HypBA1 (amino acids 380-1051), ligand-free form 2023-07-27 2024-02-21 Fujita, K.,Tsunomachi, H.,Lixia, P.,Maruyama, S.,Miyake, M.,Dakeshita, A.,Kitahara, K.,Tanaka, K.,Ito, Y.,Ishiwata, A.,Fushinobu, S. Bifidobacterial GH146 beta-L-arabinofuranosidase for the removal of beta 1,3-L-arabinofuranosides on plant glycans. Appl.Microbiol.Biotechnol. 2024 108 199 199 8IL8 Crystal structure of Pyruvic Oxime Dioxygenase (POD) from Alcaligenes faecalis 2023-03-03 2024-03-06 Tsujino, S.,Yamada, Y.,Senda, M.,Senda, T.,Fujiwara, T. Structural and functional analysis of pyruvic oxime dioxygenase, a key enzyme of heterotrophic nitrification To Be Published 0 0 0 0 8W8T 38386511 Crystal structure of human CLEC12A CRD 2023-09-04 2024-03-06 Mori, S.,Nagae, M.,Yamasaki, S. Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands. Int.Immunol. 2024 0 0 0 8W9H 38386511 Crystal structure of anti-human CLEC12A antibody 50C1 2023-09-05 2024-03-06 Mori, S.,Nagae, M.,Yamasaki, S. Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands. Int.Immunol. 2024 0 0 0 8W9J 38386511 Crystal structure of human CLEC12A ectodomain complexed with 50C1 Fab 2023-09-05 2024-03-06 Mori, S.,Nagae, M.,Yamasaki, S. Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands. Int.Immunol. 2024 0 0 0 8IQA Crystal structure of Pyruvic Oxime Dioxygenase (POD) from Alcaligenes faecalis deleted N-terminal 18 residues 2023-03-16 2024-03-20 Tsujino, S.,Yamada, Y.,Senda, M.,Senda, T.,Fujiwara, T. Structural and functional analysis of pyruvic oxime dioxygenase, a key enzyme of heterotrophic nitrification To Be Published 0 0 0 0