PDB_ID PUBMED_CID STRUCTURE TITLE DEPOSITION DATE RELEASE DATE AUTHORS CITATION TITLE JOURNAL YEAR VOLUME FIRST PAGE LAST PAGE 1V4T 15016359 Crystal structure of human glucokinase 2003-11-19 2004-03-30 Kamata, K.,Mitsuya, M.,Nishimura, T.,Eiki, J.,Nagata, Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase Structure 2004 12 429 438 1WLJ 15527770 human ISG20 2004-06-28 2004-12-21 Horio, T.,Murai, M.,Inoue, T.,Hamasaki, T.,Tanaka, T.,Ohgi, T. Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease Febs Lett. 2004 577 111 116 1X8X 15663931 Tyrosyl t-RNA Synthetase from E.coli Complexed with Tyrosine 2004-08-19 2005-01-25 Kobayashi, T.,Takimura, T.,Sekine, R.,Kelly, V.P.,Kamata, K.,Sakamoto, K.,Nishimura, S.,Yokoyama, S. Structural Snapshots of the KMSKS Loop Rearrangement for Amino Acid Activation by Bacterial Tyrosyl-tRNA Synthetase J.MOL.BIOL. 2005 346 105 117 1WCY 15255191 Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A 2004-05-07 2005-05-07 Hiramatsu, H.,Yamamoto, A.,Kyono, K.,Higashiyama, Y.,Fukushima, C.,Shima, H.,Sugiyama, S.,Inaka, K.,Shimizu, R. The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A Biol.Chem. 2004 385 561 564 1TUO Crystal structure of putative phosphomannomutase from Thermus Thermophilus HB8 2004-06-25 2005-08-09 Misaki, S.,Suzuki, S.,Fujimoto, S.,Sakurai, M.,Kobayashi, M.,Nishijima, K.,Kunishima, N.,Sugawara, M.,Kuroishi, C. Crystal structure of putative phosphomannomutase from Thermus Thermophilus HB8 TO BE PUBLISHED 0 0 0 0 1TVO 16139248 The structure of ERK2 in complex with a small molecule inhibitor 2004-06-30 2005-09-13 Ohori, M.,Kinoshita, T.,Okubo, M.,Sato, K.,Yamazaki, A.,Arakawa, H.,Nishimura, S.,Inamura, N.,Nakajima, H.,Neya, M.,Miyake, H.,Fujii, T. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex Biochem.Biophys.Res.Commun. 2005 336 357 363 1WZY 16242327 Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative 2005-03-10 2005-12-20 Kinoshita, T.,Warizaya, M.,Ohori, M.,Sato, K.,Neya, M.,Fujii, T. Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative Bioorg.Med.Chem.Lett. 2006 16 55 58 2CUY Crystal structure of malonyl CoA-acyl carrier protein transacylase from Thermus thermophilus HB8 2005-05-31 2006-06-13 Misaki, S.,Suzuki, K.,Kunishima, N.,Sugawara, M.,Kuroishi, C. Crystal structure of malonyl CoA-acyl carrier protein transacylase from Thermus thermophilus HB8 TO BE PUBLISHED 0 0 0 0 2DTS 17368483 Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1 2006-07-14 2007-03-13 Matsumiya, S.,Yamaguchi, Y.,Saito, J.,Nagano, M.,Sasakawa, H.,Otaki, S.,Satoh, M.,Shitara, K.,Kato, K. Structural comparison of fucosylated and nonfucosylated fc fragments of human immunoglobulin g1 J.Mol.Biol. 2007 368 767 779 2E2B 17376680 Crystal structure of the c-Abl kinase domain in complex with INNO-406 2006-11-10 2007-05-22 Horio, T.,Hamasaki, T.,Inoue, T.,Wakayama, T.,Itou, S.,Naito, H.,Asaki, T.,Hayase, H.,Niwa, T. Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives Bioorg.Med.Chem.Lett. 2007 17 2712 2717 2Z2L 17724158 Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae 2007-05-23 2007-09-04 Yamada, M.,Watanabe, T.,Miyara, T.,Baba, N.,Saito, J.,Takeuchi, Y.,Ohsawa, F. Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity Antimicrob.Agents Chemother. 2007 51 3902 3907 2Z2M 17724158 Cefditoren-Acylated Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae 2007-05-23 2007-09-04 Yamada, M.,Watanabe, T.,Miyara, T.,Baba, N.,Saito, J.,Takeuchi, Y.,Ohsawa, F. Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity Antimicrob.Agents Chemother. 2007 51 3902 3907 2E0A 21904029 Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with AMPPNP 2006-10-03 2007-10-09 Kukimoto-Niino, M.,Tokmakov, A.,Terada, T.,Ohbayashi, N.,Fujimoto, T.,Gomi, S.,Shiromizu, I.,Kawamoto, M.,Matsusue, T.,Shirouzu, M.,Yokoyama, S. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr.,Sect.D 2011 67 763 773 2Z6I 18305197 Crystal Structure of S. pneumoniae Enoyl-Acyl Carrier Protein Reductase (FabK) 2007-08-01 2008-04-01 Saito, J.,Yamada, M.,Watanabe, T.,Iida, M.,Kitagawa, H.,Takahata, S.,Ozawa, T.,Takeuchi, Y.,Ohsawa, F. Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor. Protein Sci. 2008 17 691 699 2Z6J 18305197 Crystal Structure of S. pneumoniae Enoyl-Acyl Carrier Protein Reductase (FabK) in Complex with an Inhibitor 2007-08-01 2008-04-01 Saito, J.,Yamada, M.,Watanabe, T.,Iida, M.,Kitagawa, H.,Takahata, S.,Ozawa, T.,Takeuchi, Y.,Ohsawa, F. Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor. Protein Sci. 2008 17 691 699 2ZC3 18391040 Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae 2007-11-02 2008-04-08 Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S. Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother. 2008 52 2053 2060 2ZC4 18391040 Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae 2007-11-02 2008-04-08 Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S. Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother. 2008 52 2053 2060 3D5F Crystal Structure of PPAR-delta complex 2008-05-16 2008-06-03 Iwashita, A.,Mihara, K.,Amano, Y.,Orita, M.,Matsuoka, N. PPAR-Delta Activation Contributes to Neuroprotectio Against Thapsigargin-Induced SH-SY5Y Cell Death to be published 0 0 0 0 2ZDT 18313930 Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor 2007-11-27 2008-09-23 Asano, Y.,Kitamura, S.,Ohra, T.,Itoh, F.,Kajino, M.,Tamura, T.,Kaneko, M.,Ikeda, S.,Igata, H.,Kawamoto, T.,Sogabe, S.,Matsumoto, S.,Tanaka, T.,Yamaguchi, M.,Kimura, H.,Fukumoto, S. Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2) Bioorg.Med.Chem. 2008 16 4699 4714 2ZDU 18313304 Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor 2007-11-27 2008-09-23 Asano, Y.,Kitamura, S.,Ohra, T.,Aso, K.,Igata, H.,Tamura, T.,Kawamoto, T.,Tanaka, T.,Sogabe, S.,Matsumoto, S.,Yamaguchi, M.,Kimura, H.,Itoh, F. Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1) Bioorg.Med.Chem. 2008 16 4715 4732 2ZLB 19111934 Crystal structure of APO form of rat catechol-O-methyltransferase 2008-04-04 2008-10-07 Tsuji, E.,Okazaki, K.,Isaji, M.,Takeda, K. Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase J.Struct.Biol. 2009 165 133 139 2ZM1 18977146 Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2008-04-10 2008-10-14 Ozawa, T.,Tsuji, E.,Ozawa, M.,Handa, C.,Mukaiyama, H.,Nishimura, T.,Kobayashi, S.,Okazaki, K. The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Bioorg.Med.Chem. 2008 16 10311 10318 2ZM4 18977146 Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394) 2008-04-11 2008-10-14 Ozawa, T.,Tsuji, E.,Ozawa, M.,Handa, C.,Mukaiyama, H.,Nishimura, T.,Kobayashi, S.,Okazaki, K. The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Bioorg.Med.Chem. 2008 16 10311 10318 2ZDX 21904029 Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4 2007-11-30 2008-12-09 Kukimoto-Niino, M.,Tokmakov, A.,Terada, T.,Ohbayashi, N.,Fujimoto, T.,Gomi, S.,Shiromizu, I.,Kawamoto, M.,Matsusue, T.,Shirouzu, M.,Yokoyama, S. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr.,Sect.D 2011 67 763 773 2ZDY 21904029 Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4 2007-12-01 2008-12-09 Kukimoto-Niino, M.,Tokmakov, A.,Terada, T.,Ohbayashi, N.,Fujimoto, T.,Gomi, S.,Shiromizu, I.,Kawamoto, M.,Matsusue, T.,Shirouzu, M.,Yokoyama, S. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr.,Sect.D 2011 67 763 773 2ZVJ 19056347 Crystal structures of rat Catechol-O-Methyltransferase complexed with coumarine-based inhibitor 2008-11-07 2009-01-06 Tsuji, E.,Okazaki, K.,Takeda, K. Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor Biochem.Biophys.Res.Commun. 2009 378 494 497 2ZJ3 19059404 Isomerase domain of human glucose:fructose-6-phosphate amidotransferase 2008-02-29 2009-01-13 Nakaishi, Y.,Bando, M.,Shimizu, H.,Watanabe, K.,Goto, F.,Tsuge, H.,Kondo, K.,Komatsu, M. Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes Febs Lett. 2009 583 163 167 2ZJ4 19059404 Isomerase domain of human glucose:fructose-6-phosphate amidotransferase 2008-02-29 2009-01-13 Nakaishi, Y.,Bando, M.,Shimizu, H.,Watanabe, K.,Goto, F.,Tsuge, H.,Kondo, K.,Komatsu, M. Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes Febs Lett. 2009 583 163 167 2ZTH 19111934 Crystal structure of holo form of rat catechol-o-methyltransferase 2008-10-01 2009-01-13 Tsuji, E.,Okazaki, K.,Isaji, M.,Takeda, K. Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase J.Struct.Biol. 2009 165 133 139 2ZYB 18977146 Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2009-01-19 2009-02-03 Ozawa, T.,Tsuji, E.,Ozawa, M.,Handa, C.,Mukaiyama, H.,Nishimura, T.,Kobayashi, S.,Okazaki, K. The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Bioorg.Med.Chem. 2008 16 10311 10318 3H1V 19736020 Human glucokinase in complex with a synthetic activator 2009-04-14 2009-10-06 Takahashi, K.,Hashimoto, N.,Nakama, C.,Kamata, K.,Sasaki, K.,Yoshimoto, R.,Ohyama, S.,Hosaka, H.,Maruki, H.,Nagata, Y.,Eiki, J.,Nishimura, T. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg.Med.Chem. 2009 17 7042 7051 3A9Z 20164179 Crystal structure of ras selenocysteine lyase in complex with selenopropionate 2009-11-09 2010-03-16 Omi, R.,Kurokawa, S.,Mihara, H.,Hayashi, H.,Goto, M.,Miyahara, I.,Kurihara, T.,Hirotsu, K.,Esaki, N. Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase. J.Biol.Chem. 2010 285 12133 12139 3A2C 20057052 Crystal structure of a pyrazolopyrimidine inhibitor complex bound to MAPKAP Kinase-2 (MK2) 2009-05-12 2010-05-12 Fujino, A.,Fukushima, K.,Namiki, N.,Kosugi, T.,Takimoto-Kamimura, M. Structural analysis of an MK2-inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800 Acta Crystallogr.,Sect.D 2010 66 80 87 3AC1 Crystal structure of pyrazin derivative bound to the kinase domain of Human LCK, (Auto-phosphorylated on TYR394) 2009-12-28 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AC2 Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2009-12-28 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AC3 Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2009-12-28 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AC4 Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2009-12-28 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AC5 Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2009-12-28 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AC8 Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2009-12-29 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3ACJ Crystal structure of imidazo pyrimidine derivative bound to the kinase domain of human LCK, (Auto-phosphorylated on TYR394) 2010-01-05 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3ACK Crystal structure of Pyrrolo pyrazine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2010-01-05 2010-06-30 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3IS1 21280131 Crystal structure of functional region of UafA from Staphylococcus saprophyticus in C2 form at 2.45 angstrom resolution 2009-08-24 2010-09-08 Matsuoka, E.,Tanaka, Y.,Kuroda, M.,Shouji, Y.,Ohta, T.,Tanaka, I.,Yao, M. Crystal structure of the functional region of Uro-adherence factor A from Staphylococcus saprophyticus reveals participation of the B domain in ligand binding Protein Sci. 2011 20 406 416 3A7D Crystal Structures of rat Catechol-O-Methyltransferase complexed with new bi-substrate type inhibitor 2009-09-26 2010-09-15 Muranaka, H.,Nakatsu, M.,Tsuji, E.,Okazaki, K. Hit to Lead: Comprehensive Strategy of de novo Scaffold Generation by FBDD. Part 2: Ligand Fishing using Mass Spectrometry by Detection of Ligand-Protein Non-Covalent Complex after Matrix Click Chemistry To be Published 0 0 0 0 3A7E Crystal structure of human COMT complexed with SAM and 3,5-dinitrocatechol 2009-09-26 2010-09-15 Nonaka, Y.,Momose, T.,Ozawa, T.,Ozawa, M.,Nakatsu, M.,Tsuji, E.,Okazaki, K.,Takase, Y.,Kiyotani, T. Hit to Lead: Comprehensive Strategy of de novo Scaffold Generation by FBDD. Part 1: In silico Fragments Linking and Verification of Spatial Proximity using Inter Ligand NOE Approachs To be Published 0 0 0 0 3ARA 22404301 Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors 2010-11-25 2010-12-08 Miyakoshi, H.,Miyahara, S.,Yokogawa, T.,Chong, K.T.,Taguchi, J.,Endoh, K.,Yano, W.,Wakasa, T.,Ueno, H.,Takao, Y.,Nomura, M.,Shuto, S.,Nagasawa, H.,Fukuoka, M. Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors J.Med.Chem. 2012 55 2960 2969 3ARN 22339362 Human dUTPase in complex with novel uracil derivative 2010-12-03 2010-12-15 Miyahara, S.,Miyakoshi, H.,Yokogawa, T.,Chong, K.T.,Taguchi, J.,Muto, T.,Endoh, K.,Yano, W.,Wakasa, T.,Ueno, H.,Takao, Y.,Fujioka, A.,Hashimoto, A.,Itou, K.,Yamamura, K.,Nomura, M.,Nagasawa, H.,Shuto, S.,Fukuoka, M. Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors J.Med.Chem. 2012 55 2970 2980 3AD4 Crystal Structure of Methoxy Benzofuran Derivative bound to the Kinase domain of human LCK, (auto-phosphorylated on TYR394) 2010-01-14 2011-01-19 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AD5 Crystal structure of Triazolone derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2010-01-14 2011-01-19 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AD6 Crystal structure of Pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) 2010-01-14 2011-01-19 Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published 0 0 0 0 3AJN 21237160 Structural basis of glycine amide on suppression of protein aggregation by high resolution X-ray analysis 2010-06-09 2011-02-16 Ito, L.,Shiraki, K.,Makino, M.,Hasegawa, K.,Kumasaka, T. Glycine amide shielding on the aromatic surfaces of lysozyme: Implication for suppression of protein aggregation Febs Lett. 2011 585 555 560 3AGG 21084280 X-ray analysis of lysozyme in the absence of Arg 2010-03-31 2011-03-23 Ito, L.,Shiraki, K.,Matsuura, T.,Okumura, M.,Hasegawa, K.,Baba, S.,Yamaguchi, H.,Kumasaka, T. High-resolution X-ray analysis reveals binding of arginine to aromatic residues of lysozyme surface: implication of suppression of protein aggregation by arginine Protein Eng.Des.Sel. 2011 24 269 274 3AGH 21084280 X-ray analysis of lysozyme in the presence of 200 mM Arg 2010-03-31 2011-03-23 Ito, L.,Shiraki, K.,Matsuura, T.,Okumura, M.,Hasegawa, K.,Baba, S.,Yamaguchi, H.,Kumasaka, T. High-resolution X-ray analysis reveals binding of arginine to aromatic residues of lysozyme surface: implication of suppression of protein aggregation by arginine Protein Eng.Des.Sel. 2011 24 269 274 3AVE Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1 2011-03-04 2011-04-06 Matsumiya, S.,Yamaguchi, Y.,Saito, J.,Nagano, M.,Sasakawa, H.,Otaki, S.,Satoh, M.,Shitara, K.,Kato, K. Corrigendum to ""Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1"" [J. Mol. 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Bioorg.Med.Chem. 2011 19 4721 4729 3AZ3 21795053 Crystal Structure Analysis of Vitamin D receptor 2011-05-20 2011-11-02 Kashiwagi, H.,Ono, Y.,Shimizu, K.,Haneishi, T.,Ito, S.,Iijima, S.,Kobayashi, T.,Ichikawa, F.,Harada, S.,Sato, H.,Sekiguchi, N.,Ishigai, M.,Takahashi, T. Novel nonsecosteroidal vitamin D(3) carboxylic acid analogs for osteoporosis, and SAR analysis. Bioorg.Med.Chem. 2011 19 4721 4729 3VHE 20833055 Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor. 2011-08-24 2011-11-02 Oguro, Y.,Miyamoto, N.,Okada, K.,Takagi, T.,Iwata, H.,Awazu, Y.,Miki, H.,Hori, A.,Kamiyama, K.,Imamura, S. Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation. Bioorg.Med.Chem. 2010 18 7260 7273 3U6U Crystal structure of the putative acetylglutamate kinase from thermus thermophilus 2011-10-13 2011-11-16 Ramya, S.,Preethi, R.,Kuramitsu, S.,Yokoyama, S.,Kumarevel, T.S.,Karthe, P. The structure of first dimeric archaeal N-acetyl glutamate kinase reveals an intermediate conformation of the enzyme in the catalytic cycle To be Published 0 0 0 0 3ATN Glycine ethyl ester shielding on the aromatic surfaces of lysozyme: Implication for suppression of protein aggregation 2011-01-06 2012-03-07 Ito, L.,Shiraki, K.,Hasegawa, K.,Kumasaka, T. Glycine ethyl ester shielding on the aromatic surfaces of lysozyme: Implication for suppression of protein aggregation To be Published 0 0 0 0 3ATO Glycine ethyl ester shielding on the aromatic surfaces of lysozyme: Implication for suppression of protein aggregation 2011-01-06 2012-03-07 Ito, L.,Shiraki, K.,Hasegawa, K.,Kumasaka, T. Glycine ethyl ester shielding on the aromatic surfaces of lysozyme: Implication for suppression of protein aggregation To be Published 0 0 0 0 3UIX 22306408 Crystal structure of Pim1 kinase in complex with small molecule inhibitor 2011-11-06 2012-04-11 Tsuganezawa, K.,Watanabe, H.,Parker, L.,Yuki, H.,Taruya, S.,Nakagawa, Y.,Kamei, D.,Mori, M.,Ogawa, N.,Tomabechi, Y.,Handa, N.,Honma, T.,Yokoyama, S.,Kojima, H.,Okabe, T.,Nagano, T.,Tanaka, A. A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide. J.Mol.Biol. 2012 417 240 252 3VHK 24900475 Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder 2011-08-25 2012-09-05 Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Lawson, J.D.,Hixon, M.S.,Kimura, H.,Miki, H. A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT. 2012 3 342 346 3W55 17194451 The structure of ERK2 in complex with FR148083 2013-01-21 2013-02-06 Ohori, M.,Kinoshita, T.,Yoshimura, S.,Warizaya, M.,Nakajima, H.,Miyake, H. Role of a cysteine residue in the active site of ERK and the MAPKK family Biochem.Biophys.Res.Commun. 2007 353 633 637 3VHW 23416104 Crystal structure of the human vitamin D receptor ligand binding domain complexed with 4-MP 2011-09-08 2013-03-06 Saito, H.,Takagi, K.,Horie, K.,Kakuda, S.,Takimoto-Kamimura, M.,Ochiai, E.,Chida, T.,Harada, Y.,Takenouchi, K.,Kittaka, A. Synthesis of novel C-2 substituted vitamin D derivatives having ringed side chains and their biological evaluation on bone J.Steroid Biochem.Mol.Biol. 2013 136 3 8 3WBL 24121337 Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor 2013-05-20 2013-10-30 Fujino, A.,Fukushima, K.,Kubota, T.,Kosugi, T.,Takimoto-Kamimura, M. Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivity. J.SYNCHROTRON RADIAT. 2013 20 905 909 3W0A Crystal Structure Analysis of Vitamin D receptor 2012-10-25 2013-11-13 Kashiwagi, H.,Ohta, M.,Ono, Y.,Itoh, S.,Iijima, S.,Sato, H.,Takahashi, T. structure analysis of vitamin D3 receptor To be Published 0 0 0 0 3W0C Crystal Structure Analysis of Vitamin D receptor 2012-10-29 2013-11-13 Kashiwagi, H.,Ohta, M.,Ono, Y.,Itoh, S.,Iijima, S.,Sato, H.,Takahashi, T. structure analysis of vitamin D receptor To be Published 0 0 0 0 3W0Y Crystal Structure Analysis of Vitamin D receptor 2012-11-05 2013-11-13 Kashiwagi, H.,Ono, Y.,Itoh, S.,Iijima, S.,Ichikawa, F.,Harada, S.,Takeda, S.,Sekiguchi, N.,Ishigai, M.,Takahashi, T. Crystal Structure Analysis of Vitamin D receptor TO BE PUBLISHED 0 0 0 0 3WV2 25192810 Crystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide 2014-05-12 2014-09-24 Nara, H.,Sato, K.,Naito, T.,Mototani, H.,Oki, H.,Yamamoto, Y.,Kuno, H.,Santou, T.,Kanzaki, N.,Terauchi, J.,Uchikawa, O.,Kori, M. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1′′ binding site. Bioorg.Med.Chem. 2014 22 5487 5505 3WPT Crystal structure of closed dimer of human importin-alpha1 (Rch1) 2014-01-17 2015-01-21 Miyatake, H. 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