PDB_ID	PUBMED_CID	STRUCTURE TITLE	DEPOSITION DATE	RELEASE DATE	AUTHORS	CITATION TITLE	JOURNAL	YEAR	VOLUME	FIRST PAGE	LAST PAGE
3VH2	22055191	Crystal structure of Saccharomyces cerevisiae Atg7 (1-613)	2011-08-23	2011-09-21	Noda, N.N.,Satoo, K.,Fujioka, Y.,Kumeta, H.,Ogura, K.,Nakatogawa, H.,Ohsumi, Y.,Inagaki, F.	Structural basis of Atg8 activation by a homodimeric E1, Atg7.	Mol.Cell	2011	44	462	475	
3AV8	21760931	Refined Structure of Plant-type [2Fe-2S] Ferredoxin I from Aphanothece sacrum at 1.46 A Resolution	2011-02-28	2012-01-11	Kameda, H.,Hirabayashi, K.,Wada, K.,Fukuyama, K.	Mapping of protein-protein interaction sites in the plant-type [2Fe-2S] ferredoxin.	Plos One	2011	6	0	0	
3VLB	22496365	Crystal structure of xeg-edgp	2011-11-30	2012-04-18	Yoshizawa, T.,Shimizu, T.,Hirano, H.,Sato, M.,Hashimoto, H.	Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor	J.Biol.Chem.	2012	287	18710	18716	
3VQ2	22532668	Crystal structure of mouse TLR4/MD-2/LPS complex	2012-03-17	2012-05-09	Ohto, U.,Fukase, K.,Miyake, K.,Shimizu, T.	Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2	Proc.Natl.Acad.Sci.USA	2012	109	7421	7426	
3VMF	22772989	Archaeal protein	2011-12-12	2012-07-25	Kobayashi, K.,Saito, K.,Ishitani, R.,Ito, K.,Nureki, O.	Structural basis for translation termination by archaeal RF1 and GTP-bound EF1alpha complex	Nucleic Acids Res.	2012	40	9319	9328	
3VTA	22841692	Crystal Structure of cucumisin, a subtilisin-like endoprotease from Cucumis melo L	2012-05-23	2012-08-08	Murayama, K.,Kato-Murayama, M.,Hosaka, T.,Sotokawauchi, A.,Yokoyama, S.,Arima, K.,Shirouzu, M.	Crystal structure of cucumisin, a subtilisin-like endoprotease from Cucumis melo L	J.Mol.Biol.	2012	423	386	396	
3VU7	22859296	Crystal structure of REV1-REV7-REV3 ternary complex	2012-06-20	2012-08-08	Kikuchi, S.,Hara, K.,Shimizu, T.,Sato, M.,Hashimoto, H.	Structural basis of recruitment of DNA polymerase [zeta] by interaction between REV1 and REV7 proteins	J.Biol.Chem.	2012	287	33847	33852	
4G8A	23055527	Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS	2012-07-23	2012-10-17	Ohto, U.,Yamakawa, N.,Akashi-Takamura, S.,Miyake, K.,Shimizu, T.	Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I	J.Biol.Chem.	2012	287	40611	40617	
4GEL	23064230	Crystal structure of Zucchini	2012-08-02	2012-10-17	Nishimasu, H.,Ishizu, H.,Saito, K.,Fukuhara, S.,Kamatani, M.K.,Bonnefond, L.,Matsumoto, N.,Nishizawa, T.,Nakanaga, K.,Aoki, J.,Ishitani, R.,Siomi, H.,Siomi, M.C.,Nureki, O.	Structure and function of Zucchini endoribonuclease in piRNA biogenesis	Nature	2012	491	284	287	
4GEM	23064230	Crystal structure of Zucchini (K171A)	2012-08-02	2012-10-17	Nishimasu, H.,Ishizu, H.,Saito, K.,Fukuhara, S.,Kamatani, M.K.,Bonnefond, L.,Matsumoto, N.,Nishizawa, T.,Nakanaga, K.,Aoki, J.,Ishitani, R.,Siomi, H.,Siomi, M.C.,Nureki, O.	Structure and function of Zucchini endoribonuclease in piRNA biogenesis	Nature	2012	491	284	287	
4GEN	23064230	Crystal structure of Zucchini (monomer)	2012-08-02	2012-10-17	Nishimasu, H.,Ishizu, H.,Saito, K.,Fukuhara, S.,Kamatani, M.K.,Bonnefond, L.,Matsumoto, N.,Nishizawa, T.,Nakanaga, K.,Aoki, J.,Ishitani, R.,Siomi, H.,Siomi, M.C.,Nureki, O.	Structure and function of Zucchini endoribonuclease in piRNA biogenesis	Nature	2012	491	284	287	
4GTW	23027977	Crystal structure of mouse Enpp1 in complex with AMP	2012-08-29	2012-11-07	Kato, K.,Nishimasu, H.,Okudaira, S.,Mihara, E.,Ishitani, R.,Takagi, J.,Aoki, J.,Nureki, O.	Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.	Proc.Natl.Acad.Sci.USA	2012	109	16876	16881	
4GTX	23027977	Crystal structure of mouse Enpp1 in complex with TMP	2012-08-29	2012-11-07	Kato, K.,Nishimasu, H.,Okudaira, S.,Mihara, E.,Ishitani, R.,Takagi, J.,Aoki, J.,Nureki, O.	Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.	Proc.Natl.Acad.Sci.USA	2012	109	16876	16881	
4GTY	23027977	Crystal structure of mouse Enpp1 in complex with GMP	2012-08-29	2012-11-07	Kato, K.,Nishimasu, H.,Okudaira, S.,Mihara, E.,Ishitani, R.,Takagi, J.,Aoki, J.,Nureki, O.	Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.	Proc.Natl.Acad.Sci.USA	2012	109	16876	16881	
4GTZ	23027977	Crystal structure of mouse Enpp1 in complex with CMP	2012-08-29	2012-11-07	Kato, K.,Nishimasu, H.,Okudaira, S.,Mihara, E.,Ishitani, R.,Takagi, J.,Aoki, J.,Nureki, O.	Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.	Proc.Natl.Acad.Sci.USA	2012	109	16876	16881	
3VRH	23444054	Crystal structure of ph0300	2012-04-10	2013-03-13	Nakagawa, H.,Kuratani, M.,Goto-Ito, S.,Ito, T.,Katsura, K.,Terada, T.,Shirouzu, M.,Sekine, S.I.,Shigi, N.,Yokoyama, S.	Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA.	Proteins	2013	0	0	0	
4IJ5	23479726	Crystal Structure of a Novel-type Phosphoserine Phosphatase from <i>Hydrogenobacter thermophilus</i> TK-6	2012-12-21	2013-03-20	Chiba, Y.,Horita, S.,Ohtsuka, J.,Arai, H.,Nagata, K.,Igarashi, Y.,Tanokura, M.,Ishii, M.	Structural units important for activity of a novel-type phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6 revealed by crystal structure analysis	J.Biol.Chem.	2013	288	11448	11458	
3VV0	23519668	Crystal structure of histone methyltransferase SET7/9 in complex with DAAM-3	2012-07-10	2013-03-27	Niwa, H.,Handa, N.,Tomabechi, Y.,Honda, K.,Toyama, M.,Ohsawa, N.,Shirouzu, M.,Kagechika, H.,Hirano, T.,Umehara, T.,Yokoyama, S.	Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives	Acta Crystallogr.,Sect.D	2013	69	595	602	
3VVN	23535598	Crystal structure of MATE in the straight conformation	2012-07-27	2013-04-03	Tanaka, Y.,Hipolito, C.J.,Maturana, A.D.,Ito, K.,Kuroda, T.,Higuchi, T.,Katoh, T.,Kato, H.E.,Hattori, M.,Kumazaki, K.,Tsukazaki, T.,Ishitani, R.,Suga, H.,Nureki, O.	Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.	Nature	2013	496	247	251	
3VVO	23535598	Crystal structure of MATE in the bent conformation	2012-07-27	2013-04-03	Tanaka, Y.,Hipolito, C.J.,Maturana, A.D.,Ito, K.,Kuroda, T.,Higuchi, T.,Katoh, T.,Kato, H.E.,Hattori, M.,Kumazaki, K.,Tsukazaki, T.,Ishitani, R.,Suga, H.,Nureki, O.	Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.	Nature	2013	496	247	251	
3VVP	23535598	Crystal structure of MATE in complex with Br-NRF	2012-07-27	2013-04-03	Tanaka, Y.,Hipolito, C.J.,Maturana, A.D.,Ito, K.,Kuroda, T.,Higuchi, T.,Katoh, T.,Kato, H.E.,Hattori, M.,Kumazaki, K.,Tsukazaki, T.,Ishitani, R.,Suga, H.,Nureki, O.	Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.	Nature	2013	496	247	251	
3VVR	23535598	Crystal structure of MATE in complex with MaD5	2012-07-27	2013-04-03	Tanaka, Y.,Hipolito, C.J.,Maturana, A.D.,Ito, K.,Kuroda, T.,Higuchi, T.,Katoh, T.,Kato, H.E.,Hattori, M.,Kumazaki, K.,Tsukazaki, T.,Ishitani, R.,Suga, H.,Nureki, O.	Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.	Nature	2013	496	247	251	
3VVS	23535598	Crystal structure of MATE in complex with MaD3S	2012-07-27	2013-04-03	Tanaka, Y.,Hipolito, C.J.,Maturana, A.D.,Ito, K.,Kuroda, T.,Higuchi, T.,Katoh, T.,Kato, H.E.,Hattori, M.,Kumazaki, K.,Tsukazaki, T.,Ishitani, R.,Suga, H.,Nureki, O.	Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.	Nature	2013	496	247	251	
3W1E	23530206	Structure of FlgT, a flagellar basal body component protein	2012-11-14	2013-04-03	Terashima, H.,Li, N.,Sakuma, M.,Koike, M.,Kojima, S.,Homma, M.,Imada, K.	Insight into the assembly mechanism in the supramolecular rings of the sodium-driven Vibrio flagellar motor from the structure of FlgT	Proc.Natl.Acad.Sci.USA	2013	110	6133	6138	
3W4T	23535598	Crystal structure of MATE P26A mutant	2013-01-16	2013-04-03	Tanaka, Y.,Hipolito, C.J.,Maturana, A.D.,Ito, K.,Kuroda, T.,Higuchi, T.,Katoh, T.,Kato, H.E.,Hattori, M.,Kumazaki, K.,Tsukazaki, T.,Ishitani, R.,Suga, H.,Nureki, O.	Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.	Nature	2013	496	247	251	
3VRZ	23596204	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea	2012-04-21	2013-05-01	Saito, Y.,Yuki, H.,Kuratani, M.,Hashizume, Y.,Takagi, S.,Honma, T.,Tanaka, A.,Shirouzu, M.,Mikuni, J.,Handa, N.,Ogahara, I.,Sone, A.,Najima, Y.,Tomabechi, Y.,Wakiyama, M.,Uchida, N.,Tomizawa-Murasawa, M.,Kaneko, A.,Tanaka, S.,Suzuki, N.,Kajita, H.,Aoki, Y.,Ohara, O.,Shultz, L.D.,Fukami, T.,Goto, T.,Taniguchi, S.,Yokoyama, S.,Ishikawa, F.	A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo	Sci Transl Med	2013	5	0	0	
3VS0	23596204	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide	2012-04-21	2013-05-01	Saito, Y.,Yuki, H.,Kuratani, M.,Hashizume, Y.,Takagi, S.,Honma, T.,Tanaka, A.,Shirouzu, M.,Mikuni, J.,Handa, N.,Ogahara, I.,Sone, A.,Najima, Y.,Tomabechi, Y.,Wakiyama, M.,Uchida, N.,Tomizawa-Murasawa, M.,Kaneko, A.,Tanaka, S.,Suzuki, N.,Kajita, H.,Aoki, Y.,Ohara, O.,Shultz, L.D.,Fukami, T.,Goto, T.,Taniguchi, S.,Yokoyama, S.,Ishikawa, F.	A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo	Sci Transl Med	2013	5	0	0	
3VS1	23596204	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea	2012-04-21	2013-05-01	Saito, Y.,Yuki, H.,Kuratani, M.,Hashizume, Y.,Takagi, S.,Honma, T.,Tanaka, A.,Shirouzu, M.,Mikuni, J.,Handa, N.,Ogahara, I.,Sone, A.,Najima, Y.,Tomabechi, Y.,Wakiyama, M.,Uchida, N.,Tomizawa-Murasawa, M.,Kaneko, A.,Tanaka, S.,Suzuki, N.,Kajita, H.,Aoki, Y.,Ohara, O.,Shultz, L.D.,Fukami, T.,Goto, T.,Taniguchi, S.,Yokoyama, S.,Ishikawa, F.	A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo	Sci Transl Med	2013	5	0	0	
3VS3	23596204	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	2012-04-21	2013-05-01	Saito, Y.,Yuki, H.,Kuratani, M.,Hashizume, Y.,Takagi, S.,Honma, T.,Tanaka, A.,Shirouzu, M.,Mikuni, J.,Handa, N.,Ogahara, I.,Sone, A.,Najima, Y.,Tomabechi, Y.,Wakiyama, M.,Uchida, N.,Tomizawa-Murasawa, M.,Kaneko, A.,Tanaka, S.,Suzuki, N.,Kajita, H.,Aoki, Y.,Ohara, O.,Shultz, L.D.,Fukami, T.,Goto, T.,Taniguchi, S.,Yokoyama, S.,Ishikawa, F.	A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo	Sci Transl Med	2013	5	0	0	
3VS4	23596204	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	2012-04-21	2013-05-01	Saito, Y.,Yuki, H.,Kuratani, M.,Hashizume, Y.,Takagi, S.,Honma, T.,Tanaka, A.,Shirouzu, M.,Mikuni, J.,Handa, N.,Ogahara, I.,Sone, A.,Najima, Y.,Tomabechi, Y.,Wakiyama, M.,Uchida, N.,Tomizawa-Murasawa, M.,Kaneko, A.,Tanaka, S.,Suzuki, N.,Kajita, H.,Aoki, Y.,Ohara, O.,Shultz, L.D.,Fukami, T.,Goto, T.,Taniguchi, S.,Yokoyama, S.,Ishikawa, F.	A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo	Sci Transl Med	2013	5	0	0	
3VS5	23596204	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	2012-04-21	2013-05-01	Saito, Y.,Yuki, H.,Kuratani, M.,Hashizume, Y.,Takagi, S.,Honma, T.,Tanaka, A.,Shirouzu, M.,Mikuni, J.,Handa, N.,Ogahara, I.,Sone, A.,Najima, Y.,Tomabechi, Y.,Wakiyama, M.,Uchida, N.,Tomizawa-Murasawa, M.,Kaneko, A.,Tanaka, S.,Suzuki, N.,Kajita, H.,Aoki, Y.,Ohara, O.,Shultz, L.D.,Fukami, T.,Goto, T.,Taniguchi, S.,Yokoyama, S.,Ishikawa, F.	A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo	Sci Transl Med	2013	5	0	0	
3VS6	23596204	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate	2012-04-21	2013-05-01	Saito, Y.,Yuki, H.,Kuratani, M.,Hashizume, Y.,Takagi, S.,Honma, T.,Tanaka, A.,Shirouzu, M.,Mikuni, J.,Handa, N.,Ogahara, I.,Sone, A.,Najima, Y.,Tomabechi, Y.,Wakiyama, M.,Uchida, N.,Tomizawa-Murasawa, M.,Kaneko, A.,Tanaka, S.,Suzuki, N.,Kajita, H.,Aoki, Y.,Ohara, O.,Shultz, L.D.,Fukami, T.,Goto, T.,Taniguchi, S.,Yokoyama, S.,Ishikawa, F.	A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo	Sci Transl Med	2013	5	0	0	
3WBN	23535598	Crystal structure of MATE in complex with MaL6	2013-05-20	2013-06-12	Tanaka, Y.,Hipolito, C.J.,Matunara, A.D.,Ito, K.,Kuroda, T.,Higuchi, T.,Kato, T.,Hattori, M.,Kumazaki, K.,Kato, H.E.,Tsukazaki, T.,Ishitani, R.,Suga, H.,Nureki, O.	Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.	Nature	2013	496	247	251	
4KPP	23704374	Crystal Structure of H+/Ca2+ Exchanger CAX	2013-05-14	2013-06-26	Nishizawa, T.,Kita, S.,Maturana, A.D.,Furuya, N.,Hirata, K.,Kasuya, G.,Ogasawara, S.,Dohmae, N.,Iwamoto, T.,Ishitani, R.,Nureki, O.	Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger.	Science	2013	341	168	172	
4IKV	23798427	Crystal structure of peptide transporter POT	2012-12-28	2013-07-10	Doki, S.,Kato, H.E.,Solcan, N.,Iwaki, M.,Koyama, M.,Hattori, M.,Iwase, N.,Tsukazaki, T.,Sugita, Y.,Kandori, H.,Newstead, S.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT.	Proc.Natl.Acad.Sci.USA	2013	110	11343	11348	
4IKW	23798427	Crystal structure of peptide transporter POT in complex with sulfate	2012-12-28	2013-07-10	Doki, S.,Kato, H.E.,Solcan, N.,Iwaki, M.,Koyama, M.,Hattori, M.,Iwase, N.,Tsukazaki, T.,Sugita, Y.,Kandori, H.,Newstead, S.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT.	Proc.Natl.Acad.Sci.USA	2013	110	11343	11348	
4IKX	23798427	Crystal structure of peptide transporter POT (E310Q mutant)	2012-12-28	2013-07-10	Doki, S.,Kato, H.E.,Solcan, N.,Iwaki, M.,Koyama, M.,Hattori, M.,Iwase, N.,Tsukazaki, T.,Sugita, Y.,Kandori, H.,Newstead, S.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT.	Proc.Natl.Acad.Sci.USA	2013	110	11343	11348	
4IKY	23798427	Crystal structure of peptide transporter POT (E310Q mutant) in complex with sulfate	2012-12-28	2013-07-10	Doki, S.,Kato, H.E.,Solcan, N.,Iwaki, M.,Koyama, M.,Hattori, M.,Iwase, N.,Tsukazaki, T.,Sugita, Y.,Kandori, H.,Newstead, S.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT.	Proc.Natl.Acad.Sci.USA	2013	110	11343	11348	
4IKZ	23798427	Crystal structure of peptide transporter POT (E310Q mutant) in complex with alafosfalin	2012-12-28	2013-07-10	Doki, S.,Kato, H.E.,Solcan, N.,Iwaki, M.,Koyama, M.,Hattori, M.,Iwase, N.,Tsukazaki, T.,Sugita, Y.,Kandori, H.,Newstead, S.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT.	Proc.Natl.Acad.Sci.USA	2013	110	11343	11348	
3WAW	23688339	Crystal Structure of Autotaxin in Complex with 2BoA	2013-05-09	2013-07-31	Kawaguchi, M.,Okabe, T.,Okudaira, S.,Nishimasu, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T.	Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe	Acs Chem.Biol.	2013	8	1713	1721	
3WAX	23688339	Crystal Structure of Autotaxin in Complex with 3BoA	2013-05-09	2013-07-31	Kawaguchi, M.,Okabe, T.,Okudaira, S.,Nishimasu, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T.	Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe	Acs Chem.Biol.	2013	8	1713	1721	
3WAY	23688339	Crystal Structure of Autotaxin in Complex with 4BoA	2013-05-09	2013-07-31	Kawaguchi, M.,Okabe, T.,Okudaira, S.,Nishimasu, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T.	Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe	Acs Chem.Biol.	2013	8	1713	1721	
3W0J	23462137	Crystal Structure of Rat VDR Ligand Binding Domain in Complex with Novel Nonsecosteroidal Ligands	2012-10-30	2013-10-09	Asano, L.,Ito, I.,Kuwabara, N.,Waku, T.,Yanagisawa, J.,Miyachi, H.,Shimizu, T.	Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands.	Febs Lett.	2013	587	957	963	
3WHD	24101491	C-type lectin, human MCL	2013-08-24	2013-10-23	Furukawa, A.,Kamishikiryo, J.,Mori, D.,Toyonaga, K.,Okabe, Y.,Toji, A.,Kanda, R.,Miyake, Y.,Ose, T.,Yamasaki, S.,Maenaka, K.	Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL	Proc.Natl.Acad.Sci.USA	2013	110	17438	17443	
3WAK	24127570	Crystal structure of the Archaeoglobus fulgidus oligosaccharyltransferase (O29867_ARCFU) in the apo form	2013-05-03	2013-10-30	Matsumoto, S.,Shimada, A.,Nyirenda, J.,Igura, M.,Kawano, Y.,Kohda, D.	Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation	Proc.Natl.Acad.Sci.USA	2013	110	17868	17873	
3WJL	23744091	Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb	2013-10-11	2013-11-13	Mimoto, F.,Katada, H.,Kadono, S.,Igawa, T.,Kuramochi, T.,Muraoka, M.,Wada, Y.,Haraya, K.,Miyazaki, T.,Hattori, K.	Engineered antibody Fc variant with selectively enhanced Fc gamma RIIb binding over both Fc gamma RIIaR131 and Fc gamma RIIaH131.	Protein Eng.Des.Sel.	2013	26	589	598	
3VU3	24223139	Crystal structure of the Hfq and catalase HPII complex	2012-06-15	2013-11-20	Yonekura, K.,Watanabe, M.,Kageyama, Y.,Hirata, K.,Yamamoto, M.,Maki-Yonekura, S.	Post-Transcriptional Regulator Hfq Binds Catalase HPII: Crystal Structure of the Complex	Plos One	2013	8	0	0	
4L3O	24389023	Crystal Structure of SIRT2 in complex with the macrocyclic peptide S2iL5	2013-06-06	2014-02-19	Yamagata, K.,Goto, Y.,Nishimasu, H.,Morimoto, J.,Ishitani, R.,Dohmae, N.,Takeda, N.,Nagai, R.,Komuro, I.,Suga, H.,Nureki, O.	Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change	Structure	2013	22	345	352	
4ME6	24440607	Crystal structure of D-alanine-D-alanine ligase A from Xanthomonas oryzae pathovar oryzae with ADP	2013-08-25	2014-02-19	Doan, T.N.N.,Kim, J.K.,Ngo, H.P.T.,Tran, H.T.,Cha, S.S.,Chung, K.M.,Huynh, K.H.,Ahn, Y.J.,Kang, L.W.	Crystal structures of d-alanine-d-alanine ligase from Xanthomonas oryzae pv. oryzae alone and in complex with nucleotides	Arch.Biochem.Biophys.	2014	0	92	99	
4OO8	24529477	Crystal structure of Streptococcus pyogenes Cas9 in complex with guide RNA and target DNA	2014-01-31	2014-02-26	Nishimasu, H.,Ran, F.A.,Hsu, P.D.,Konermann, S.,Shehata, S.I.,Dohmae, N.,Ishitani, R.,Zhang, F.,Nureki, O.	Crystal structure of Cas9 in complex with guide RNA and target DNA	Cell(Cambridge,Mass.)	2014	156	935	949	
3W7N		Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-149	2013-03-02	2014-03-05	Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K.	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-149	To be Published	0	0	0	0	
3W85		Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-139	2013-03-12	2014-03-12	Inaoka, D.K.,Iida, M.,Tabuchi, T.,Lee, N.,Hashimoto, S.,Matsuoka, S.,Kuranaga, T.,Shiba, T.,Sakamoto, K.,Suzuki, S.,Balogun, E.O.,Nara, T.,Aoki, T.,Inoue, M.,Honma, T.,Tanaka, A.,Harada, S.,Kita, K.	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-139	To be Published	0	0	0	0	
3WOE	24589779	Crystal structure of P23-45 gp39 (6-109) bound to Thermus thermophilus RNA polymerase beta-flap domain	2013-12-26	2014-03-12	Tagami, S.,Sekine, S.,Minakhin, L.,Esyunina, D.,Akasaka, R.,Shirouzu, M.,Kulbachinskiy, A.,Severinov, K.,Yokoyama, S.	Structural basis for promoter specificity switching of RNA polymerase by a phage factor.	Genes Dev.	2014	28	521	531	
3WO6	24739968	Crystal structure of YidC from Bacillus halodurans (form I)	2013-12-20	2014-04-23	Kumazaki, K.,Chiba, S.,Takemoto, M.,Furukawa, A.,Nishiyama, K.,Sugano, Y.,Mori, T.,Dohmae, N.,Hirata, K.,Nakada-Nakura, Y.,Maturana, A.D.,Tanaka, Y.,Mori, H.,Sugita, Y.,Arisaka, F.,Ito, K.,Ishitani, R.,Tsukazaki, T.,Nureki, O.	Structural basis of Sec-independent membrane protein insertion by YidC.	Nature	2014	509	516	520	
3WO7	24739968	Crystal structure of YidC from Bacillus halodurans (form II)	2013-12-20	2014-04-23	Kumazaki, K.,Chiba, S.,Takemoto, M.,Furukawa, A.,Nishiyama, K.,Sugano, Y.,Mori, T.,Dohmae, N.,Hirata, K.,Nakada-Nakura, Y.,Maturana, A.D.,Tanaka, Y.,Mori, H.,Sugita, Y.,Arisaka, F.,Ito, K.,Ishitani, R.,Tsukazaki, T.,Nureki, O.	Structural basis of Sec-independent membrane protein insertion by YidC.	Nature	2014	509	516	520	
4P79	24744376	Crystal structure of mouse claudin-15	2014-03-26	2014-04-30	Suzuki, H.,Nishizawa, T.,Tani, K.,Yamazaki, Y.,Tamura, A.,Ishitani, R.,Dohmae, N.,Tsukita, S.,Nureki, O.,Fujiyoshi, Y.	Crystal structure of a claudin provides insight into the architecture of tight junctions.	Science	2014	344	304	307	
3WAE	24419392	X-ray structure of Fe(III)-bicarbonates-ttfbpa, a ferric ion-binding protein from thermus thermophilus HB8	2013-05-02	2014-05-21	Wang, S.,Ogata, M.,Horita, S.,Ohtsuka, J.,Nagata, K.,Tanokura, M.	A novel mode of ferric ion coordination by the periplasmic ferric ion-binding subunit FbpA of an ABC-type iron transporter from Thermus thermophilus HB8.	Acta Crystallogr.,Sect.D	2014	70	196	202	
3WPX	25197056	Structure of PomBc4, a periplasmic fragment of PomB from Vibrio alginolyticus	2014-01-17	2014-09-10	Zhu, S.,Takao, M.,Li, N.,Sakuma, M.,Nishino, Y.,Homma, M.,Kojima, S.,Imada, K.	Conformational change in the periplasmic region of the flagellar stator coupled with the assembly around the rotor	Proc. Natl. Acad. Sci. U.S.A.	2014	111	13523	13528	
3WVL	25174333	Crystal structure of the football-shaped GroEL-GroES complex (GroEL: GroES2:ATP14) from Escherichia coli	2014-05-23	2014-09-17	Koike-Takeshita, A.,Arakawa, T.,Taguchi, H.,Shimamura, T.	Crystal structure of a symmetric football-shaped GroEL:GroES2-ATP14 complex determined at 3.8 angstrom reveals rearrangement between two GroEL rings.	J.Mol.Biol.	2014	426	3634	3641	
4RNG	25378180	Crystal structure of a bacterial homologue of SWEET transporters	2014-10-24	2014-11-19	Wang, J.,Yan, C.,Li, Y.,Hirata, K.,Yamamoto, M.,Yan, N.,Hu, Q.	Crystal structure of a bacterial homologue of SWEET transporters.	Cell Res.	2014	24	1486	1489	
4U9L	25367295	Structure of a membrane protein	2014-08-06	2014-12-03	Takeda, H.,Hattori, M.,Nishizawa, T.,Yamashita, K.,Shah, S.T.,Caffrey, M.,Maturana, A.D.,Ishitani, R.,Nureki, O.	Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE	Nat Commun	2014	5	5374	5374	
4U9N	25367295	Structure of a membrane protein	2014-08-06	2014-12-03	Takeda, H.,Hattori, M.,Nishizawa, T.,Yamashita, K.,Shah, S.T.,Caffrey, M.,Maturana, A.D.,Ishitani, R.,Nureki, O.	Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE	Nat Commun	2014	5	5374	5374	
4WIB	25367295	Crystal structure of Magnesium transporter MgtE	2014-09-25	2014-12-03	Takeda, H.,Hattori, M.,Nishizawa, T.,Yamashita, K.,Shah, S.T.,Caffrey, M.,Maturana, A.D.,Ishitani, R.,Nureki, O.	Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg(2+) channel MgtE	Nat Commun	2014	5	5374	5374	
3WVF	25466392	Crystal structure of YidC from Escherichia coli	2014-05-20	2014-12-17	Kumazaki, K.,Kishimoto, T.,Furukawa, A.,Mori, H.,Tanaka, Y.,Dohmae, N.,Ishitani, R.,Tsukazaki, T.,Nureki, O.	Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase	Sci Rep	2014	4	7299	7299	
3X29	25678664	CRYSTAL STRUCTURE of MOUSE CLAUDIN-19 IN COMPLEX with C-TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS ENTEROTOXIN	2014-12-13	2015-01-21	Saitoh, Y.,Suzuki, H.,Tani, K.,Nishikawa, K.,Irie, K.,Ogura, Y.,Tamura, A.,Tsukita, S.,Fujiyoshi, Y.	Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin	Science	2015	347	775	778	
4X5M	25598322	Crystal structure of SemiSWEET in the inward-open conformation	2014-12-05	2015-01-21	Lee, Y.,Nishizawa, T.,Yamashita, K.,Ishitani, R.,Nureki, O.	Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter	Nat Commun	2015	6	6112	6112	
4X5N	25598322	Crystal structure of SemiSWEET in the inward-open and outward-open conformations	2014-12-05	2015-01-21	Lee, Y.,Nishizawa, T.,Yamashita, K.,Ishitani, R.,Nureki, O.	Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter	Nat Commun	2015	6	6112	6112	
4PDN	25274739	Crystal structure of E. coli YfcM	2014-04-19	2015-03-04	Kobayashi, K.,Katz, A.,Rajkovic, A.,Ishii, R.,Branson, O.E.,Freitas, M.A.,Ishitani, R.,Ibba, M.,Nureki, O.	The non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation.	Nucleic Acids Res.	2014	42	12295	12305	
3X2S	25646669	Crystal structure of pyrene-conjugated adenylate kinase	2014-12-31	2015-04-01	Fujii, A.,Sekiguchi, Y.,Matsumura, H.,Inoue, T.,Chung, W.S.,Hirota, S.,Matsuo, T.	Excimer Emission Properties on Pyrene-Labeled Protein Surface: Correlation between Emission Spectra, Ring Stacking Modes, and Flexibilities of Pyrene Probes.	Bioconjug.Chem.	2015	26	537	548	
3X3B	25849775	Crystal structure of the light-driven sodium pump KR2 in acidic state	2015-01-18	2015-04-08	Kato, H.E.,Inoue, K.,Abe-Yoshizumi, R.,Kato, Y.,Ono, H.,Konno, M.,Hososhima, S.,Ishizuka, T.,Hoque, M.R.,Kunitomo, H.,Ito, J.,Yoshizawa, S.,Yamashita, K.,Takemoto, M.,Nishizawa, T.,Taniguchi, R.,Kogure, K.,Maturana, A.D.,Iino, Y.,Yawo, H.,Ishitani, R.,Kandori, H.,Nureki, O.	Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump	Nature	2015	521	48	53	
3X3C	25849775	Crystal structure of the light-driven sodium pump KR2 in neutral state	2015-01-18	2015-04-08	Kato, H.E.,Inoue, K.,Abe-Yoshizumi, R.,Kato, Y.,Ono, H.,Konno, M.,Hososhima, S.,Ishizuka, T.,Hoque, M.R.,Kunitomo, H.,Ito, J.,Yoshizawa, S.,Yamashita, K.,Takemoto, M.,Nishizawa, T.,Taniguchi, R.,Kogure, K.,Maturana, A.D.,Iino, Y.,Yawo, H.,Ishitani, R.,Kandori, H.,Nureki, O.	Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump	Nature	2015	521	48	53	
4YBG	25865890	Crystal structure of the MAEL domain of Drosophila melanogaster Maelstrom	2015-02-18	2015-04-29	Matsumoto, N.,Sato, K.,Nishimasu, H.,Namba, Y.,Miyakubi, K.,Dohmae, N.,Ishitani, R.,Siomi, H.,Siomi, M.C.,Nureki, O.	Crystal Structure and Activity of the Endoribonuclease Domain of the piRNA Pathway Factor Maelstrom	Cell Rep	2015	11	366	375	
4YZI	25975962	Crystal structure of blue-shifted channelrhodopsin mutant (T198G/G202A)	2015-03-25	2015-05-27	Kato, H.E.,Kamiya, M.,Sugo, S.,Ito, J.,Taniguchi, R.,Orito, A.,Hirata, K.,Inutsuka, A.,Yamanaka, A.,Maturana, A.D.,Ishitani, R.,Sudo, Y.,Hayashi, S.,Nureki, O.	Atomistic design of microbial opsin-based blue-shifted optogenetics tools.	Nat Commun	2015	6	7177	7177	
3WZ3	26039110	Structure of a periplasmic fragment of TraM	2014-09-18	2015-06-10	Kuroda, T.,Kubori, T.,Thanh Bui, X.,Hyakutake, A.,Uchida, Y.,Imada, K.,Nagai, H.	Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion	Sci Rep	2015	5	10912	10912	
4U4T	25959928	Structure of a nitrate/nitrite antiporter NarK in nitrate-bound inward-open state	2014-07-24	2015-07-15	Fukuda, M.,Takeda, H.,Kato, H.E.,Doki, S.,Ito, K.,Maturana, A.D.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK	Nat Commun	2015	6	7097	7097	
4U4V	25959928	Structure of a nitrate/nitrite antiporter NarK in apo inward-open state	2014-07-24	2015-07-15	Fukuda, M.,Takeda, H.,Kato, H.E.,Doki, S.,Ito, K.,Maturana, A.D.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK	Nat Commun	2015	6	7097	7097	
4U4W	25959928	Structure of a nitrate/nitrite antiporter NarK in nitrate-bound occluded state	2014-07-24	2015-07-15	Fukuda, M.,Takeda, H.,Kato, H.E.,Doki, S.,Ito, K.,Maturana, A.D.,Ishitani, R.,Nureki, O.	Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK	Nat Commun	2015	6	7097	7097	
4YVK	26183229	Crystal Structure of H. influenzae TrmD in complex with sinefungin and tRNA variant (G36C)	2015-03-20	2015-07-15	Ito, T.,Masuda, I.,Yoshida, K.,Goto-Ito, S.,Sekine, S.,Suh, S.W.,Hou, Y.M.,Yokoyama, S.	Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.	Proc.Natl.Acad.Sci.USA	2015	112	0	0	
4ZW9	26176916	Crystal structure of human GLUT3 bound to D-glucose in the outward-occluded conformation at 1.5 angstrom	2015-05-19	2015-07-22	Deng, D.,Sun, P.C.,Yan, C.Y.,Ke, M.,Jiang, X.,Xiong, L.,Ren, W.,Hirata, K.,Yamamoto, M.,Fan, S.,Yan, N.	Molecular basis of ligand recognition and transport by glucose transporters	Nature	2015	526	391	396	
4ZWB	26176916	Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at 2.4 angstrom	2015-05-19	2015-07-22	Deng, D.,Sun, P.C.,Yan, C.Y.,Ke, M.,Jiang, X.,Xiong, L.,Ren, W.,Hirata, K.,Yamamoto, M.,Fan, S.,Yan, N.	Molecular basis of ligand recognition and transport by glucose transporters	Nature	2015	526	391	396	
4ZWC	26176916	Crystal structure of maltose-bound human GLUT3 in the outward-open conformation at 2.6 angstrom	2015-05-19	2015-07-22	Deng, D.,Sun, P.C.,Yan, C.Y.,Ke, M.,Jiang, X.,Xiong, L.,Ren, W.,Hirata, K.,Yamamoto, M.,Fan, S.,Yan, N.	Molecular basis of ligand recognition and transport by glucose transporters	Nature	2015	526	391	396	
5AWM	26377800	The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins.	2015-07-06	2015-08-05	Chimnaronk, S.,Sitthiroongruang, J.,Srisucharitpanit, K.,Srisaisup, M.,Ketterman, A.J.,Boonserm, P.	The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins.	Bmc Struct.Biol.	2015	15	17	17	
5AWZ	26527138	Crystal Structure of the Cell-Free Synthesized Membrane Protein, Acetabularia Rhodopsin I, at 1.57 angstrom	2015-07-10	2015-08-26	Furuse, M.,Tamogami, J.,Hosaka, T.,Kikukawa, T.,Shinya, N.,Hato, M.,Ohsawa, N.,Kim, S.Y.,Jung, K.H.,Demura, M.,Miyauchi, S.,Kamo, N.,Shimono, K.,Kimura-Someya, T.,Yokoyama, S.,Shirouzu, M.	Structural basis for the slow photocycle and late proton release in Acetabularia rhodopsin I from the marine plant Acetabularia acetabulum	Acta Crystallogr.,Sect.D	2015	71	2203	2216	
5AX0	26527138	Crystal Structure of the Cell-Free Synthesized Membrane Protein, Acetabularia Rhodopsin I, at 1.52 angstrom	2015-07-10	2015-08-26	Furuse, M.,Tamogami, J.,Hosaka, T.,Kikukawa, T.,Shinya, N.,Hato, M.,Ohsawa, N.,Kim, S.Y.,Jung, K.H.,Demura, M.,Miyauchi, S.,Kamo, N.,Shimono, K.,Kimura-Someya, T.,Yokoyama, S.,Shirouzu, M.	Structural basis for the slow photocycle and late proton release in Acetabularia rhodopsin I from the marine plant Acetabularia acetabulum	Acta Crystallogr.,Sect.D	2015	71	2203	2216	
5AX1	26527138	Crystal Structure of the Cell-Free Synthesized Membrane Protein, Acetabularia Rhodopsin I, at 1.80 angstrom	2015-07-10	2015-08-26	Furuse, M.,Tamogami, J.,Hosaka, T.,Kikukawa, T.,Shinya, N.,Hato, M.,Ohsawa, N.,Kim, S.Y.,Jung, K.H.,Demura, M.,Miyauchi, S.,Kamo, N.,Shimono, K.,Kimura-Someya, T.,Yokoyama, S.,Shirouzu, M.	Structural basis for the slow photocycle and late proton release in Acetabularia rhodopsin I from the marine plant Acetabularia acetabulum	Acta Crystallogr.,Sect.D	2015	71	2203	2216	
5AYM	26461048	Crystal structure of a bacterial homologue of iron transporter ferroportin in outward-facing state with soaked iron	2015-08-25	2015-11-04	Taniguchi, R.,Kato, H.E.,Font, J.,Deshpande, C.N.,Wada, M.,Ito, K.,Ishitani, R.,Jormakka, M.,Nureki, O.	Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin	Nat Commun	2015	6	8545	8545	
5AYN	26461048	Crystal structure of a bacterial homologue of iron transporter ferroportin in outward-facing state	2015-08-25	2015-11-04	Taniguchi, R.,Kato, H.E.,Font, J.,Deshpande, C.N.,Wada, M.,Ito, K.,Ishitani, R.,Jormakka, M.,Nureki, O.	Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin	Nat Commun	2015	6	8545	8545	
5AYO	26461048	Crystal structure of a bacterial homologue of iron transporter ferroportin in inward-facing state	2015-08-25	2015-11-04	Taniguchi, R.,Kato, H.E.,Font, J.,Deshpande, C.N.,Wada, M.,Ito, K.,Ishitani, R.,Jormakka, M.,Nureki, O.	Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin	Nat Commun	2015	6	8545	8545	
5AXU	26503073	Crystal Structure of Cypovirus Polyhedra R13A Mutant	2015-08-01	2015-11-11	Abe, S.,Ijiri, H.,Negishi, H.,Yamanaka, H.,Sasaki, K.,Hirata, K.,Mori, H.,Ueno, T.	Design of Enzyme-Encapsulated Protein Containers by In Vivo Crystal Engineering	Adv. Mater. Weinheim	2015	27	7951	7956	
5AXV	26503073	Crystal Structure of Cypovirus Polyhedra R13K Mutant	2015-08-01	2015-11-11	Abe, S.,Ijiri, H.,Negishi, H.,Yamanaka, H.,Sasaki, K.,Hirata, K.,Mori, H.,Ueno, T.	Design of Enzyme-Encapsulated Protein Containers by In Vivo Crystal Engineering	Adv. Mater. Weinheim	2015	27	7951	7956	
5AWW	26586438	Precise Resting State of Thermus thermophilus SecYEG	2015-07-10	2015-11-25	Tanaka, Y.,Sugano, Y.,Takemoto, M.,Mori, T.,Furukawa, A.,Kusakizako, T.,Kumazaki, K.,Kashima, A.,Ishitani, R.,Sugita, Y.,Nureki, O.,Tsukazaki, T.	Crystal Structures of SecYEG in Lipidic Cubic Phase Elucidate a Precise Resting and a Peptide-Bound State.	Cell Rep	2015	13	1561	1568	
5CH4	26586438	Peptide-Bound State of Thermus thermophilus SecYEG	2015-07-10	2015-11-25	Tanaka, Y.,Sugano, Y.,Takemoto, M.,Mori, T.,Furukawa, A.,Kusakizako, T.,Kumazaki, K.,Kashima, A.,Ishitani, R.,Sugita, Y.,Nureki, O.,Tsukazaki, T.	Crystal Structures of SecYEG in Lipidic Cubic Phase Elucidate a Precise Resting and a Peptide-Bound State.	Cell Rep	2015	13	1561	1568	
5AV5	26607036	human nucleosome core particle	2015-06-11	2015-12-23	Wakamori, M.,Fujii, Y.,Suka, N.,Shirouzu, M.,Sakamoto, K.,Umehara, T.,Yokoyama, S.	Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation	Sci Rep	2015	5	17204	17204	
5AV6	26607036	human nucleosome core particle	2015-06-12	2015-12-23	Wakamori, M.,Fujii, Y.,Suka, N.,Shirouzu, M.,Sakamoto, K.,Umehara, T.,Yokoyama, S.	Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation	Sci Rep	2015	5	17204	17204	
5AV8	26607036	human nucleosome core particle	2015-06-12	2015-12-23	Wakamori, M.,Fujii, Y.,Suka, N.,Shirouzu, M.,Sakamoto, K.,Umehara, T.,Yokoyama, S.	Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation	Sci Rep	2015	5	17204	17204	
5AV9	26607036	human nucleosome core particle	2015-06-12	2015-12-23	Wakamori, M.,Fujii, Y.,Suka, N.,Shirouzu, M.,Sakamoto, K.,Umehara, T.,Yokoyama, S.	Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation	Sci Rep	2015	5	17204	17204	
5AVB	26607036	human nucleosome core particle	2015-06-12	2015-12-23	Wakamori, M.,Fujii, Y.,Suka, N.,Shirouzu, M.,Sakamoto, K.,Umehara, T.,Yokoyama, S.	Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation	Sci Rep	2015	5	17204	17204	
5AVC	26607036	human nucleosome core particle	2015-06-12	2015-12-23	Wakamori, M.,Fujii, Y.,Suka, N.,Shirouzu, M.,Sakamoto, K.,Umehara, T.,Yokoyama, S.	Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation	Sci Rep	2015	5	17204	17204	
5AZG	26687600	Crystal structure of LGG-1 complexed with a UNC-51 peptide	2015-10-05	2015-12-30	Wu, F.,Watanabe, Y.,Guo, X.Y.,Qi, X.,Wang, P.,Zhao, H.Y.,Wang, Z.,Fujioka, Y.,Zhang, H.,Ren, J.Q.,Fang, T.C.,Shen, Y.X.,Feng, W.,Hu, J.J.,Noda, N.N.,Zhang, H.	Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.	Mol.Cell	2015	60	914	929	
5AZH	26687600	Crystal structure of LGG-2 fused with an EEEWEEL peptide	2015-10-05	2015-12-30	Wu, F.,Watanabe, Y.,Guo, X.Y.,Qi, X.,Wang, P.,Zhao, H.Y.,Wang, Z.,Fujioka, Y.,Zhang, H.,Ren, J.Q.,Fang, T.C.,Shen, Y.X.,Feng, W.,Hu, J.J.,Noda, N.N.,Zhang, H.	Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.	Mol.Cell	2015	60	914	929	
5AZ6	26694222	Crystal structure of MBP-Tom20 fusion protein with a 2-residue spacer in the connector helix	2015-09-27	2016-01-13	Matsuoka, R.,Shimada, A.,Komuro, Y.,Sugita, Y.,Kohda, D.	Rational design of crystal contact-free space in protein crystals for analyzing spatial distribution of motions within protein molecules.	Protein Sci.	2016	25	754	768	
5AZA	26694222	Crystal structure of MBP-sAglB fusion protein with a 20-residue spacer in the connector helix	2015-09-27	2016-01-13	Matsuoka, R.,Shimada, A.,Komuro, Y.,Sugita, Y.,Kohda, D.	Rational design of crystal contact-free space in protein crystals for analyzing spatial distribution of motions within protein molecules.	Protein Sci.	2016	25	754	768	
4YSO	26769972	Copper nitrite reductase from Geobacillus thermodenitrificans - 0.064 MGy	2015-03-17	2016-02-24	Fukuda, Y.,Tse, K.M.,Suzuki, M.,Diederichs, K.,Hirata, K.,Nakane, T.,Sugahara, M.,Nango, E.,Tono, K.,Joti, Y.,Kameshima, T.,Song, C.,Hatsui, T.,Yabashi, M.,Nureki, O.,Matsumura, H.,Inoue, T.,Iwata, S.,Mizohata, E.	Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography	J.Biochem.	2016	159	527	538	
4YSP	26769972	Structure of copper nitrite reductase from Geobacillus thermodenitrificans - 8.32 MGy	2015-03-17	2016-02-24	Fukuda, Y.,Tse, K.M.,Suzuki, M.,Diederichs, K.,Hirata, K.,Nakane, T.,Sugahara, M.,Nango, E.,Tono, K.,Joti, Y.,Kameshima, T.,Song, C.,Hatsui, T.,Yabashi, M.,Nureki, O.,Matsumura, H.,Inoue, T.,Iwata, S.,Mizohata, E.	Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography	J.Biochem.	2016	159	527	538	
4YSQ	26769972	Structure of copper nitrite reductase from Geobacillus thermodenitrificans - 8.38 MGy	2015-03-17	2016-02-24	Fukuda, Y.,Tse, K.M.,Suzuki, M.,Diederichs, K.,Hirata, K.,Nakane, T.,Sugahara, M.,Nango, E.,Tono, K.,Joti, Y.,Kameshima, T.,Song, C.,Hatsui, T.,Yabashi, M.,Nureki, O.,Matsumura, H.,Inoue, T.,Iwata, S.,Mizohata, E.	Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography	J.Biochem.	2016	159	527	538	
4YSR	26769972	Structure of copper nitrite reductase from Geobacillus thermodenitrificans - 16.6 MGy	2015-03-17	2016-02-24	Fukuda, Y.,Tse, K.M.,Suzuki, M.,Diederichs, K.,Hirata, K.,Nakane, T.,Sugahara, M.,Nango, E.,Tono, K.,Joti, Y.,Kameshima, T.,Song, C.,Hatsui, T.,Yabashi, M.,Nureki, O.,Matsumura, H.,Inoue, T.,Iwata, S.,Mizohata, E.	Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography	J.Biochem.	2016	159	527	538	
4YSS	26769972	Structure of copper nitrite reductase from Geobacillus thermodenitrificans - 16.7 MGy	2015-03-17	2016-02-24	Fukuda, Y.,Tse, K.M.,Suzuki, M.,Diederichs, K.,Hirata, K.,Nakane, T.,Sugahara, M.,Nango, E.,Tono, K.,Joti, Y.,Kameshima, T.,Song, C.,Hatsui, T.,Yabashi, M.,Nureki, O.,Matsumura, H.,Inoue, T.,Iwata, S.,Mizohata, E.	Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography	J.Biochem.	2016	159	527	538	
4YST	26769972	Structure of copper nitrite reductase from Geobacillus thermodenitrificans - 24.9 MGy	2015-03-17	2016-02-24	Fukuda, Y.,Tse, K.M.,Suzuki, M.,Diederichs, K.,Hirata, K.,Nakane, T.,Sugahara, M.,Nango, E.,Tono, K.,Joti, Y.,Kameshima, T.,Song, C.,Hatsui, T.,Yabashi, M.,Nureki, O.,Matsumura, H.,Inoue, T.,Iwata, S.,Mizohata, E.	Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography	J.Biochem.	2016	159	527	538	
4YSU	26769972	Structure of copper nitrite reductase from Geobacillus thermodenitrificans - 25.0 MGy	2015-03-17	2016-02-24	Fukuda, Y.,Tse, K.M.,Suzuki, M.,Diederichs, K.,Hirata, K.,Nakane, T.,Sugahara, M.,Nango, E.,Tono, K.,Joti, Y.,Kameshima, T.,Song, C.,Hatsui, T.,Yabashi, M.,Nureki, O.,Matsumura, H.,Inoue, T.,Iwata, S.,Mizohata, E.	Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography	J.Biochem.	2016	159	527	538	
4YN3	27616715	Crystal structure of Cucumisin complex with pro-peptide	2015-03-09	2016-03-09	Sotokawauchi, A.,Kato-Murayama, M.,Murayama, K.,Hosaka, T.,Maeda, I.,Onjo, M.,Ohsawa, N.,Kato, D.I.,Arima, K.,Shirouzu, M.	Structural basis of cucumisin protease activity regulation by its propeptide	J. Biochem.	2017	161	45	53	
5HRT	27043297	Crystal structure of mouse autotaxin in complex with a DNA aptamer	2016-01-24	2016-04-06	Kato, K.,Ikeda, H.,Miyakawa, S.,Futakawa, S.,Nonaka, Y.,Fujiwara, M.,Okudaira, S.,Kano, K.,Aoki, J.,Morita, J.,Ishitani, R.,Nishimasu, H.,Nakamura, Y.,Nureki, O.	Structural basis for specific inhibition of Autotaxin by a DNA aptamer	Nat.Struct.Mol.Biol.	2016	23	395	401	
5I20	27281193	Crystal structure of protein	2016-02-08	2016-06-01	Tsuchiya, H.,Doki, S.,Takemoto, M.,Ikuta, T.,Higuchi, T.,Fukui, K.,Usuda, Y.,Tabuchi, E.,Nagatoishi, S.,Tsumoto, K.,Nishizawa, T.,Ito, K.,Dohmae, N.,Ishitani, R.,Nureki, O.	Structural basis for amino acid export by DMT superfamily transporter YddG.	Nature	2016	534	417	420	
5B2I	27419055	Human nucleosome containing CpG unmethylated DNA	2016-01-16	2016-06-15	Fujii, Y.,Wakamori, M.,Umehara, T.,Yokoyama, S.	Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation.	Febs Open Bio	2016	6	498	514	
5B2J	27419055	Human nucleosome containing CpG methylated DNA	2016-01-18	2016-06-15	Fujii, Y.,Wakamori, M.,Umehara, T.,Yokoyama, S.	Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation.	Febs Open Bio	2016	6	498	514	
5C2K		Crystal structure of the fusion protein linked by RhoA and the GAP domain of MgcRacGAP	2015-06-16	2016-06-22	Murayama, K.,Kato-Murayama, M.,Hosaka, T.,kawashima, T.,Kitamura, T.,Yokoyama, S.,Shirouzu, M.	Structural basis of G-protein target alternation of MgcRacGAP by phospholylation	To Be Published	0	0	0	0	
5IRL	27283905	Crystal structure of rabbit NOD2 SER mutant in an ADP-bound state	2016-03-14	2016-06-29	Maekawa, S.,Ohto, U.,Shibata, T.,Miyake, K.,Shimizu, T.	Crystal structure of NOD2 and its implications in human disease.	Nat Commun	2016	7	11813	11813	
5IRM	27283905	Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form2)	2016-03-14	2016-06-29	Maekawa, S.,Ohto, U.,Shibata, T.,Miyake, K.,Shimizu, T.	Crystal structure of NOD2 and its implications in human disease.	Nat Commun	2016	7	11813	11813	
5AWS	26822536	Crystal structure of the SGIP1 mu homology domain in the P1 space group	2015-07-08	2016-07-06	Shimada, A.,Yamaguchi, A.,Kohda, D.	Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.	Sci Rep	2016	6	19565	19565	
5B2N	27365396	Crystal structure of the light-driven chloride ion-pumping rhodopsin, ClP, from Nonlabens marinus	2016-01-20	2016-07-13	Hosaka, T.,Yoshizawa, S.,Nakajima, Y.,Ohsawa, N.,Hato, M.,DeLong, E.F.,Kogure, K.,Yokoyama, S.,Kimura-Someya, T.,Iwasaki, W.,Shirouzu, M.	Structural Mechanism for Light-driven Transport by a New Type of Chloride Ion Pump, Nonlabens marinus Rhodopsin-3	J.Biol.Chem.	2016	291	17488	17495	
5AX9	27562646	Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase in complex with compund 9	2015-07-21	2016-07-27	Masuda, M.,Uno, Y.,Ohbayashi, N.,Ohata, H.,Mimata, A.,Kukimoto-Niino, M.,Moriyama, H.,Kashimoto, S.,Inoue, T.,Goto, N.,Okamoto, K.,Shirouzu, M.,Sawa, M.,Yamada, T.	TNIK inhibition abrogates colorectal cancer stemness	Nat Commun	2016	7	12586	12586	
5AUM		Crystal structure of a Fab fragment with the ligand peptide	2015-04-30	2016-08-10	Kitago, Y.,Takagi, J.	Crystal structure of a Fab fragment with the ligand peptide	To Be Published	0	0	0	0	
5GGI	27493216	Crystal structure of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase in complex with Mn, UDP and Mannosyl-peptide	2016-06-16	2016-08-10	Kuwabara, N.,Manya, H.,Yamada, T.,Tateno, H.,Kanagawa, M.,Kobayashi, K.,Akasaka-Manya, K.,Hirose, Y.,Mizuno, M.,Ikeguchi, M.,Toda, T.,Hirabayashi, J.,Senda, T.,Endo, T.,Kato, R.	Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of alpha-dystroglycan	Proc.Natl.Acad.Sci.USA	2016	113	9280	9285	
5GLH	27595334	Human endothelin receptor type-B in complex with ET-1	2016-07-11	2016-09-07	Shihoya, W.,Nishizawa, T.,Okuta, A.,Tani, K.,Dohmae, N.,Fujiyoshi, Y.,Nureki, O.,Doi, T.	Activation mechanism of endothelin ETB receptor by endothelin-1.	Nature	2016	537	363	368	
5GLI	27595334	Human endothelin receptor type-B in the ligand-free form	2016-07-11	2016-09-07	Shihoya, W.,Nishizawa, T.,Okuta, A.,Tani, K.,Dohmae, N.,Fujiyoshi, Y.,Nureki, O.,Doi, T.	Activation mechanism of endothelin ETB receptor by endothelin-1.	Nature	2016	537	363	368	
5AZY	27569046	Crystal structure of p24delta1 GOLD domain (Native 2)	2015-10-23	2016-09-14	Nagae, M.,Hirata, T.,Morita-Matsumoto, K.,Theiler, R.,Fujita, M.,Kinoshita, T.,Yamaguchi, Y.	3D Structure and Interaction of p24 beta and p24 delta Golgi Dynamics Domains: Implication for p24 Complex Formation and Cargo Transport	J.Mol.Biol.	2016	428	4087	4099	
5B4C	27609419	Crystal structure of H10N mutant of LpxH with manganese	2016-04-03	2016-09-28	Okada, C.,Wakabayashi, H.,Kobayashi, M.,Shinoda, A.,Tanaka, I.,Yao, M.	Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa	Sci Rep	2016	6	32822	32822	
5GVS	27721487	Crystal structure of the DDX41 DEAD domain in an apo open form	2016-09-06	2016-10-19	Omura, H.,Oikawa, D.,Nakane, T.,Kato, M.,Ishii, R.,Ishitani, R.,Tokunaga, F.,Nureki, O.	Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide	Sci Rep	2016	6	34756	34756	
5GXB	27791182	crystal structure of a LacY/Nanobody complex	2016-09-16	2016-10-26	Jiang, X.,Smirnova, I.,Kasho, V.,Wu, J.,Hirata, K.,Ke, M.,Pardon, E.,Steyaert, J.,Yan, N.,Kaback, H.R.	Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.	Proc.Natl.Acad.Sci.USA	2016	113	12420	12425	
5B4W	27984026	Crystal structure of Plexin inhibitor complex	2016-04-19	2016-12-28	Matsunaga, Y.,Bashiruddin, N.K.,Kitago, Y.,Takagi, J.,Suga, H.	Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide	Cell Chem Biol	2016	23	1341	1350	
5B3T	28169272	Crystal structure of apo-form biliverdin reductase from Synechocystis sp. PCC 6803	2016-03-12	2017-02-15	Takao, H.,Hirabayashi, K.,Nishigaya, Y.,Kouriki, H.,Nakaniwa, T.,Hagiwara, Y.,Harada, J.,Sato, H.,Yamazaki, T.,Sakakibara, Y.,Suiko, M.,Asada, Y.,Takahashi, Y.,Yamamoto, K.,Fukuyama, K.,Sugishima, M.,Wada, K.	A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity	Nat Commun	2017	8	14397	14397	
5B3U	28169272	Crystal structure of biliverdin reductase in complex with NADP+ from Synechocystis sp. PCC 6803	2016-03-13	2017-02-15	Takao, H.,Hirabayashi, K.,Nishigaya, Y.,Kouriki, H.,Nakaniwa, T.,Hagiwara, Y.,Harada, J.,Sato, H.,Yamazaki, T.,Sakakibara, Y.,Suiko, M.,Asada, Y.,Takahashi, Y.,Yamamoto, K.,Fukuyama, K.,Sugishima, M.,Wada, K.	A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity	Nat Commun	2017	8	14397	14397	
5GQL	28094987	Crystal structure of Wild Type Cypovirus Polyhedra	2016-08-07	2017-02-15	Abe, S.,Tabe, H.,Ijiri, H.,Yamashita, K.,Hirata, K.,Atsumi, K.,Shimoi, T.,Akai, M.,Mori, H.,Kitagawa, S.,Ueno, T.	Crystal Engineering of Self-Assembled Porous Protein Materials in Living Cells	ACS Nano	2017	11	2410	2419	
5GQM	28094987	Crystal structure of in cellulo Wild Type Cypovirus Polyhedra	2016-08-07	2017-02-15	Abe, S.,Tabe, H.,Ijiri, H.,Yamashita, K.,Hirata, K.,Atsumi, K.,Shimoi, T.,Akai, M.,Mori, H.,Kitagawa, S.,Ueno, T.	Crystal Engineering of Self-Assembled Porous Protein Materials in Living Cells	ACS Nano	2017	11	2410	2419	
5GQN	28094987	Crystal structure of in cellulo Cypovirus Polyhedra mutant with deletion of Gly192-Ala194	2016-08-07	2017-02-15	Abe, S.,Tabe, H.,Ijiri, H.,Yamashita, K.,Hirata, K.,Atsumi, K.,Shimoi, T.,Akai, M.,Mori, H.,Kitagawa, S.,Ueno, T.	Crystal Engineering of Self-Assembled Porous Protein Materials in Living Cells	ACS Nano	2017	11	2410	2419	
5LWY	28329765	Revised crystal structure of the human adiponectin receptor 2 in complex with a C18 free fatty acid	2016-09-19	2017-03-22	Vasiliauskaite-Brooks, I.,Sounier, R.,Rochaix, P.,Bellot, G.,Fortier, M.,Hoh, F.,De Colibus, L.,Bechara, C.,Saied, E.M.,Arenz, C.,Leyrat, C.,Granier, S.	Structural insights into adiponectin receptors suggest ceramidase activity.	Nature	2017	6	120	123	
5LXG	28329765	Revised crystal structure of the human adiponectin receptor 1 in an open conformation	2016-09-21	2017-03-22	Vasiliauskaite-Brooks, I.,Sounier, R.,Rochaix, P.,Bellot, G.,Fortier, M.,Hoh, F.,De Colibus, L.,Bechara, C.,Saied, E.M.,Arenz, C.,Leyrat, C.,Granier, S.	Structural insights into adiponectin receptors suggest ceramidase activity.	Nature	2017	6	120	123	
5B71	28439081	Crystal structure of complement C5 in complex with SKY59	2016-06-03	2017-05-03	Fukuzawa, T.,Sampei, Z.,Haraya, K.,Ruike, Y.,Shida-Kawazoe, M.,Shimizu, Y.,Gan, S.W.,Irie, M.,Tsuboi, Y.,Tai, H.,Sakiyama, T.,Sakamoto, A.,Ishii, S.,Maeda, A.,Iwayanagi, Y.,Shibahara, N.,Shibuya, M.,Nakamura, G.,Nambu, T.,Hayasaka, A.,Mimoto, F.,Okura, Y.,Hori, Y.,Habu, K.,Wada, M.,Miura, T.,Tachibana, T.,Honda, K.,Tsunoda, H.,Kitazawa, T.,Kawabe, Y.,Igawa, T.,Hattori, K.,Nezu, J.	Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.	Sci Rep	2017	7	1080	1080	
5B4F	28439027	Sulfur Transferase TtuA in complex with iron sulfur cluster	2016-04-03	2017-05-10	Chen, M.,Asai, S.I.,Narai, S.,Nambu, S.,Omura, N.,Sakaguchi, Y.,Suzuki, T.,Ikeda-Saito, M.,Watanabe, K.,Yao, M.,Shigi, N.,Tanaka, Y.	Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA	Proc. Natl. Acad. Sci. U.S.A.	2017	114	4954	4959	
5X4Z	28412353	RNA Polymerase II from Komagataella Pastoris (Type-1 crystal)	2017-02-14	2017-05-17	Ehara, H.,Umehara, T.,Sekine, S.I.,Yokoyama, S.	Crystal structure of RNA polymerase II from Komagataella pastoris	Biochem. Biophys. Res. Commun.	2017	487	230	235	
5XAM	28467902	Crystal structure of SecDF in I form at 4 A resolution	2017-03-14	2017-05-17	Furukawa, A.,Yoshikaie, K.,Mori, T.,Mori, H.,Morimoto, Y.V.,Sugano, Y.,Iwaki, S.,Minamino, T.,Sugita, Y.,Tanaka, Y.,Tsukazaki, T.	Tunnel Formation Inferred from the I-Form Structures of the Proton-Driven Protein Secretion Motor SecDF	Cell Rep	2017	19	895	901	
5XAN	28467902	Crystal structure of SecDF in I form (P212121 space group)	2017-03-14	2017-05-17	Furukawa, A.,Yoshikaie, K.,Mori, T.,Mori, H.,Morimoto, Y.V.,Sugano, Y.,Iwaki, S.,Minamino, T.,Sugita, Y.,Tanaka, Y.,Tsukazaki, T.	Tunnel Formation Inferred from the I-Form Structures of the Proton-Driven Protein Secretion Motor SecDF	Cell Rep	2017	19	895	901	
5XAP	28467902	Crystal structure of SecDF in I form (C2 space group)	2017-03-14	2017-05-17	Furukawa, A.,Yoshikaie, K.,Mori, T.,Mori, H.,Morimoto, Y.V.,Sugano, Y.,Iwaki, S.,Minamino, T.,Sugita, Y.,Tanaka, Y.,Tsukazaki, T.	Tunnel Formation Inferred from the I-Form Structures of the Proton-Driven Protein Secretion Motor SecDF	Cell Rep	2017	19	895	901	
5JYJ		Crystal structure of mouse JUNO	2016-05-14	2017-05-24	Kato, K.,Satouh, Y.,Nishimasu, H.,Kurabayashi, A.,Morita, J.,Fujihara, Y.,Oji, A.,Ishitani, R.,Ikawa, M.,Nureki, O.	Crystal structure of the egg IZUMO1 receptor JUNO	To Be Published	0	0	0	0	
5GJ3	28913898	Periplasmic heme-binding protein RhuT from Roseiflexus sp. RS-1 in two-heme bound form (holo-2)	2016-06-26	2017-06-28	Naoe, Y.,Nakamura, N.,Rahman, M.M.,Tosha, T.,Nagatoishi, S.,Tsumoto, K.,Shiro, Y.,Sugimoto, H.	Structural basis for binding and transfer of heme in bacterial heme-acquisition systems.	Proteins	2017	85	2217	2230	
5XDN	28608415	Crystal structure of human voltage-dependent anion channel 1 (hVDAC1) in P22121 space group	2017-03-28	2017-06-28	Hosaka, T.,Okazaki, M.,Kimura-Someya, T.,Ishizuka-Katsura, Y.,Ito, K.,Yokoyama, S.,Dodo, K.,Sodeoka, M.,Shirouzu, M.	Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1	Protein Sci.	2017	26	1749	1758	
5XDO	28608415	Crystal structure of human voltage-dependent anion channel 1 (hVDAC1) in C222 space group	2017-03-28	2017-06-28	Hosaka, T.,Okazaki, M.,Kimura-Someya, T.,Ishizuka-Katsura, Y.,Ito, K.,Yokoyama, S.,Dodo, K.,Sodeoka, M.,Shirouzu, M.	Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1	Protein Sci.	2017	26	1749	1758	
5XDU	28621933	Staphylococcus aureus FtsZ 12-316 complexed with TXA6101	2017-03-30	2017-08-02	Fujita, J.,Maeda, Y.,Mizohata, E.,Inoue, T.,Kaul, M.,Parhi, A.K.,LaVoie, E.J.,Pilch, D.S.,Matsumura, H.	Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ	ACS Chem. Biol.	2017	12	1947	1955	
5X7D	28813418	Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist	2017-02-25	2017-08-16	Liu, X.,Ahn, S.,Kahsai, A.W.,Meng, K.C.,Latorraca, N.R.,Pani, B.,Venkatakrishnan, A.J.,Masoudi, A.,Weis, W.I.,Dror, R.O.,Chen, X.,Lefkowitz, R.J.,Kobilka, B.K.	Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure.	Nature	2017	548	480	484	
5X93	28805809	Human endothelin receptor type-B in complex with antagonist K-8794	2017-03-05	2017-08-16	Shihoya, W.,Nishizawa, T.,Yamashita, K.,Inoue, A.,Hirata, K.,Kadji, F.M.N.,Okuta, A.,Tani, K.,Aoki, J.,Fujiyoshi, Y.,Doi, T.,Nureki, O.	X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog	Nat. Struct. Mol. Biol.	2017	24	758	764	
5XPR	28805809	Human endothelin receptor type-B in complex with antagonist bosentan	2017-06-04	2017-08-16	Shihoya, W.,Nishizawa, T.,Yamashita, K.,Inoue, A.,Hirata, K.,Kadji, F.M.N.,Okuta, A.,Tani, K.,Aoki, J.,Fujiyoshi, Y.,Doi, T.,Nureki, O.	X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog	Nat. Struct. Mol. Biol.	2017	24	758	764	
5XSZ	28792932	Crystal structure of zebrafish lysophosphatidic acid receptor LPA6	2017-06-16	2017-08-16	Taniguchi, R.,Inoue, A.,Sayama, M.,Uwamizu, A.,Yamashita, K.,Hirata, K.,Yoshida, M.,Tanaka, Y.,Kato, H.E.,Nakada-Nakura, Y.,Otani, Y.,Nishizawa, T.,Doi, T.,Ohwada, T.,Ishitani, R.,Aoki, J.,Nureki, O.	Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6	Nature	2017	548	356	360	
5X1C	28878401	Crystal Structure of Human CRMP-2 without C-terminal Tail	2017-01-25	2017-09-20	Niwa, S.,Nakamura, F.,Tomabechi, Y.,Aoki, M.,Shigematsu, H.,Matsumoto, T.,Yamagata, A.,Fukai, S.,Hirokawa, N.,Goshima, Y.,Shirouzu, M.,Nitta, R.	Structural basis for CRMP2-induced axonal microtubule formation	Sci Rep	2017	7	10681	10681	
5XJJ	28877507	Crystal structure of a MATE family protein	2017-05-02	2017-09-20	Tanaka, Y.,Iwaki, S.,Tsukazaki, T.	Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein	Structure	2017	25	1455	0	
5YCK	28877507	Crystal structure of a MATE family protein derived from Camelina sativa at 2.3 angstrom	2017-09-07	2017-09-27	Tanaka, Y.,Iwaki, S.,Tsukazaki, T.	Crystal Structure of a Plant Multidrug and Toxic Compound Extrusion Family Protein	Structure	2017	25	1455	0	
5Y78	28970497	Crystal structure of the triose-phosphate/phosphate translocator in complex with inorganic phosphate	2017-08-16	2017-10-04	Lee, Y.,Nishizawa, T.,Takemoto, M.,Kumazaki, K.,Yamashita, K.,Hirata, K.,Minoda, A.,Nagatoishi, S.,Tsumoto, K.,Ishitani, R.,Nureki, O.	Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity	Nat Plants	2017	3	825	832	
5Y78	28970497	Crystal structure of the triose-phosphate/phosphate translocator in complex with inorganic phosphate	2017-08-16	2017-10-04	Lee, Y.,Nishizawa, T.,Takemoto, M.,Kumazaki, K.,Yamashita, K.,Hirata, K.,Minoda, A.,Nagatoishi, S.,Tsumoto, K.,Ishitani, R.,Nureki, O.	Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity	Nat Plants	2017	3	825	832	
5Y79	28970497	Crystal structure of the triose-phosphate/phosphate translocator in complex with 3-phosphoglycerate	2017-08-16	2017-10-04	Lee, Y.,Nishizawa, T.,Takemoto, M.,Kumazaki, K.,Yamashita, K.,Hirata, K.,Minoda, A.,Nagatoishi, S.,Tsumoto, K.,Ishitani, R.,Nureki, O.	Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity	Nat Plants	2017	3	825	832	
5H0B	28662963	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoic acid	2016-10-04	2017-10-11	Yuki, H.,Kikuzato, K.,Koda, Y.,Mikuni, J.,Tomabechi, Y.,Kukimoto-Niino, M.,Tanaka, A.,Shirai, F.,Shirouzu, M.,Koyama, H.,Honma, T.	Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.	Bioorg. Med. Chem.	2017	25	4259	4264	
5Y8B	28913898	Periplasmic heme-binding protein RhuT from Roseiflexus sp. RS-1 in apo form	2017-08-20	2017-10-11	Naoe, Y.,Nakamura, N.,Rahman, M.M.,Tosha, T.,Nagatoishi, S.,Tsumoto, K.,Shiro, Y.,Sugimoto, H.	Structural basis for binding and transfer of heme in bacterial heme-acquisition systems	Proteins	2017	85	2217	2230	
5XO2	29046357	Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide II	2017-05-25	2017-10-25	Furukawa, A.,Kakita, K.,Yamada, T.,Ishizuka, M.,Sakamoto, J.,Hatori, N.,Maeda, N.,Ohsaka, F.,Saitoh, T.,Nomura, T.,Kuroki, K.,Nambu, H.,Arase, H.,Matsunaga, S.,Anada, M.,Ose, T.,Hashimoto, S.,Maenaka, K.	Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILR alpha immune cell receptor.	J. Biol. Chem.	2017	292	21128	21136	
5WQC	29225076	Crystal structure of human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8.	2016-11-25	2017-11-29	Suno, R.,Kimura, K.T.,Nakane, T.,Yamashita, K.,Wang, J.,Fujiwara, T.,Yamanaka, Y.,Im, D.,Horita, S.,Tsujimoto, H.,Tawaramoto, M.S.,Hirokawa, T.,Nango, E.,Tono, K.,Kameshima, T.,Hatsui, T.,Joti, Y.,Yabashi, M.,Shimamoto, K.,Yamamoto, M.,Rosenbaum, D.M.,Iwata, S.,Shimamura, T.,Kobayashi, T.	Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA	Structure	2018	26	7	0	
5YHA	29138769	Crystal structure of Pd(allyl)/Wild Type Polyhedra	2017-09-27	2017-11-29	Abe, S.,Atsumi, K.,Yamashita, K.,Hirata, K.,Mori, H.,Ueno, T.	Structure of in cell protein crystals containing organometallic complexes.	Phys Chem Chem Phys	2018	20	2986	2989	
5YHB	29138769	Crystal structure of Pd(allyl)/polyhedra mutant with deletion of Gly192-Ala194	2017-09-27	2017-11-29	Abe, S.,Atsumi, K.,Yamashita, K.,Hirata, K.,Mori, H.,Ueno, T.	Structure of in cell protein crystals containing organometallic complexes.	Phys Chem Chem Phys	2018	20	2986	2989	
5Y50	29158478	Crystal structure of eukaryotic MATE transporter AtDTX14	2017-08-06	2017-12-06	Miyauchi, H.,Moriyama, S.,Kusakizako, T.,Kumazaki, K.,Nakane, T.,Yamashita, K.,Hirata, K.,Dohmae, N.,Nishizawa, T.,Ito, K.,Miyaji, T.,Moriyama, Y.,Ishitani, R.,Nureki, O.	Structural basis for xenobiotic extrusion by eukaryotic MATE transporter	Nat Commun	2017	8	1633	1633	
5YUB	29274127	Crystal structure of voltage-gated sodium channel NavAb E32Q mutant	2017-11-21	2017-12-27	Irie, K.,Haga, Y.,Shimomura, T.,Fujiyoshi, Y.	Structural insight on the voltage dependence of prokaryotic voltage gated sodium channel NavAb.	FEBS Lett.	2017	0	0	0	
5YUC	29274127	Crystal structure of voltage-gated sodium channel NavAb N49K mutant	2017-11-21	2017-12-27	Irie, K.,Haga, Y.,Shimomura, T.,Fujiyoshi, Y.	Structural insight on the voltage dependence of prokaryotic voltage gated sodium channel NavAb.	FEBS Lett.	2017	0	0	0	
5X33	29309055	Leukotriene B4 receptor BLT1 in complex with BIIL260	2017-02-03	2018-01-03	Hori, T.,Okuno, T.,Hirata, K.,Yamashita, K.,Kawano, Y.,Yamamoto, M.,Hato, M.,Nakamura, M.,Shimizu, T.,Yokomizo, T.,Miyano, M.,Yokoyama, S.	Na+-mimicking ligands stabilize the inactive state of leukotriene B4receptor BLT1.	Nat. Chem. Biol.	2018	14	262	269	
5YHF	29398525	Crystal structure of SecDF in Super-membrane-facing form	2017-09-28	2018-02-14	Furukawa, A.,Nakayama, S.,Yoshikaie, K.,Tanaka, Y.,Tsukazaki, T.	Remote Coupled Drastic beta-Barrel to beta-Sheet Transition of the Protein Translocation Motor.	Structure	2018	26	485	0	
5YR1	29405208	Crystal Structure of Cypovirus Polyhedra R13A/E73C/Y83C/S193C/A194C Mutant	2017-11-08	2018-02-21	Negishi, H.,Abe, S.,Yamashita, K.,Hirata, K.,Niwase, K.,Boudes, M.,Coulibaly, F.,Mori, H.,Ueno, T.	Supramolecular protein cages constructed from a crystalline protein matrix	Chem. Commun. (Camb.)	2018	54	1988	1991	
5YR9	29405208	Crystal Structure of Cypovirus Polyhedra R13A/E73C/Y83C Mutant	2017-11-08	2018-02-21	Negishi, H.,Abe, S.,Yamashita, K.,Hirata, K.,Niwase, K.,Boudes, M.,Coulibaly, F.,Mori, H.,Ueno, T.	Supramolecular protein cages constructed from a crystalline protein matrix	Chem. Commun. (Camb.)	2018	54	1988	1991	
5YRB	29405208	Crystal Structure of Oxidized Cypovirus Polyhedra R13A/E73C/Y83C/S193C/A194C Mutant	2017-11-09	2018-02-21	Negishi, H.,Abe, S.,Yamashita, K.,Hirata, K.,Niwase, K.,Boudes, M.,Coulibaly, F.,Mori, H.,Ueno, T.	Supramolecular protein cages constructed from a crystalline protein matrix	Chem. Commun. (Camb.)	2018	54	1988	1991	
5YRC	29405208	Crystal Structure of Oxidized Cypovirus Polyhedra R13A/E73C/Y83C Mutant	2017-11-09	2018-02-21	Negishi, H.,Abe, S.,Yamashita, K.,Hirata, K.,Niwase, K.,Boudes, M.,Coulibaly, F.,Mori, H.,Ueno, T.	Supramolecular protein cages constructed from a crystalline protein matrix	Chem. Commun. (Camb.)	2018	54	1988	1991	
5WXJ	29440735	Apo EarP	2017-01-07	2018-02-28	Sengoku, T.,Suzuki, T.,Dohmae, N.,Watanabe, C.,Honma, T.,Hikida, Y.,Yamaguchi, Y.,Takahashi, H.,Yokoyama, S.,Yanagisawa, T.	Structural basis of protein arginine rhamnosylation by glycosyltransferase EarP	Nat. Chem. Biol.	2018	14	368	374	
5YLV	29618813	Crystal structure of the gastric proton pump complexed with SCH28080	2017-10-19	2018-04-11	Abe, K.,Irie, K.,Nakanishi, H.,Suzuki, H.,Fujiyoshi, Y.	Crystal structures of the gastric proton pump	Nature	2018	556	214	218	
5Y9M	29717996	Crystal structure of CK2a2 form 3	2017-08-25	2018-05-16	Tsuyuguchi, M.,Nakaniwa, T.,Kinoshita, T.	Crystal structures of human CK2 alpha 2 in new crystal forms arising from a subtle difference in salt concentration	Acta Crystallogr F Struct Biol	2018	74	288	293	
5XJM	29967536	Complex structure of angiotensin II type 2 receptor with Fab	2017-05-02	2018-07-11	Asada, H.,Horita, S.,Hirata, K.,Shiroishi, M.,Shiimura, Y.,Iwanari, H.,Hamakubo, T.,Shimamura, T.,Nomura, N.,Kusano-Arai, O.,Uemura, T.,Suno, C.,Kobayashi, T.,Iwata, S.	Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog	Nat. Struct. Mol. Biol.	2018	25	570	576	
5YTL	30082512	Crystal structure of Geobacillus thermodenitrificans copper-containing nitrite reductase determined with an anaerobically manipulated crystal	2017-11-19	2018-08-22	Fukuda, Y.,Matsusaki, T.,Tse, K.M.,Mizohata, E.,Murphy, M.E.P.,Inoue, T.	Crystallographic study of dioxygen chemistry in a copper-containing nitrite reductase from Geobacillus thermodenitrificans.	Acta Crystallogr D Struct Biol	2018	74	769	777	
5ZCW	30224964	Structure of the Methanosarcina mazei class II CPD-photolyase in complex with intact, phosphodiester linked, CPD-lesion	2018-02-21	2018-08-22	Maestre-Reyna, M.,Yamamoto, J.,Huang, W.C.,Tsai, M.D.,Essen, L.O.,Bessho, Y.	Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA.	IUCrJ	2018	5	608	618	
5Y7Z	30214852	Complex structure of cyclin G-associated kinase with gefitinib	2017-08-18	2018-08-29	Ohbayashi, N.,Murayama, K.,Kato-Murayama, M.,Kukimoto-Niino, M.,Uejima, T.,Matsuda, T.,Ohsawa, N.,Yokoyoma, S.,Nojima, H.,Shirouzu, M.	Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib.	ChemistryOpen	2018	7	721	727	
5Y80	30214852	Complex structure of cyclin G-associated kinase with gefitinib	2017-08-18	2018-08-29	Ohbayashi, N.,Murayama, K.,Kato-Murayama, M.,Kukimoto-Niino, M.,Uejima, T.,Matsuda, T.,Ohsawa, N.,Yokoyoma, S.,Nojima, H.,Shirouzu, M.	Structural Basis for the Inhibition of Cyclin G-Associated Kinase by Gefitinib.	ChemistryOpen	2018	7	721	727	
6CSO	30158697	Crystal structure of the designed light-gated anion channel iC++ at pH6.5	2018-03-21	2018-09-05	Kato, H.E.,Kim, Y.S.,Paggi, J.M.,Evans, K.E.,Allen, W.E.,Richardson, C.,Inoue, K.,Ito, S.,Ramakrishnan, C.,Fenno, L.E.,Yamashita, K.,Hilger, D.,Lee, S.Y.,Berndt, A.,Shen, K.,Kandori, H.,Dror, R.O.,Kobilka, B.K.,Deisseroth, K.	Structural mechanisms of selectivity and gating in anion channelrhodopsins.	Nature	2018	561	349	354	
6BTX	30082682	Structure of a bacterial metal transporter	2017-12-08	2018-09-19	Deshpande, C.N.,Ruwe, T.A.,Shawki, A.,Xin, V.,Vieth, K.R.,Valore, E.V.,Qiao, B.,Ganz, T.,Nemeth, E.,Mackenzie, B.,Jormakka, M.	Calcium is an essential cofactor for metal efflux by the ferroportin transporter family.	Nat Commun	2018	9	3075	3075	
5ZLE	30272000	Human duodenal cytochrome b (Dcytb) in substrate free form	2018-03-27	2018-10-31	Ganasen, M.,Togashi, H.,Takeda, H.,Asakura, H.,Tosha, T.,Yamashita, K.,Hirata, K.,Nariai, Y.,Urano, T.,Yuan, X.,Hamza, I.,Mauk, A.G.,Shiro, Y.,Sugimoto, H.,Sawai, H.	Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.	Commun Biol	2018	1	120	120	
5ZLG	30272000	Human duodenal cytochrome b (Dcytb) in zinc ion and ascorbate bound form	2018-03-27	2018-10-31	Ganasen, M.,Togashi, H.,Takeda, H.,Asakura, H.,Tosha, T.,Yamashita, K.,Hirata, K.,Nariai, Y.,Urano, T.,Yuan, X.,Hamza, I.,Mauk, A.G.,Shiro, Y.,Sugimoto, H.,Sawai, H.	Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.	Commun Biol	2018	1	120	120	
6AL2	30241934	Crystal structure of E. coli YidC at 2.8 A resolution	2018-09-05	2018-11-07	Tanaka, Y.,Izumioka, A.,Abdul Hamid, A.,Fujii, A.,Haruyama, T.,Furukawa, A.,Tsukazaki, T.	2.8-angstrom crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop.	Biochem. Biophys. Res. Commun.	2018	505	141	145	
5YC8	30420692	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS (Hg-derivative)	2017-09-06	2018-11-21	Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T.	Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor	Nat. Chem. Biol.	2018	14	1150	1158	
5ZIH	30258177	Crystal structure of the red light-activated channelrhodopsin Chrimson.	2018-03-15	2018-11-21	Oda, K.,Vierock, J.,Oishi, S.,Rodriguez-Rozada, S.,Taniguchi, R.,Yamashita, K.,Wiegert, J.S.,Nishizawa, T.,Hegemann, P.,Nureki, O.	Crystal structure of the red light-activated channelrhodopsin Chrimson.	Nat Commun	2018	9	3949	3949	
5ZK3	30420692	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB	2018-03-23	2018-11-21	Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T.	Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor	Nat. Chem. Biol.	2018	14	1150	1158	
5ZK8	30420692	Crystal structure of M2 muscarinic acetylcholine receptor bound with NMS	2018-03-23	2018-11-21	Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T.	Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor	Nat. Chem. Biol.	2018	14	1150	1158	
5ZKB	30420692	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384	2018-03-23	2018-11-21	Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T.	Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor	Nat. Chem. Biol.	2018	14	1150	1158	
5ZKC	30420692	Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS	2018-03-23	2018-11-21	Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T.	Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor	Nat. Chem. Biol.	2018	14	1150	1158	
6IGK	30413709	Crystal Structure of human ETB receptor in complex with Endothelin-3	2018-09-25	2018-11-21	Shihoya, W.,Izume, T.,Inoue, A.,Yamashita, K.,Kadji, F.M.N.,Hirata, K.,Aoki, J.,Nishizawa, T.,Nureki, O.	Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.	Nat Commun	2018	9	4711	4711	
6IGL	30413709	Crystal Structure of human ETB receptor in complex with IRL1620	2018-09-25	2018-11-21	Shihoya, W.,Izume, T.,Inoue, A.,Yamashita, K.,Kadji, F.M.N.,Hirata, K.,Aoki, J.,Nishizawa, T.,Nureki, O.	Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.	Nat Commun	2018	9	4711	4711	
6IQZ	30156345	High resolution structure of bilirubin oxidase from Myrothecium verrucaria - wild type	2018-11-09	2018-11-21	Akter, M.,Tokiwa, T.,Shoji, M.,Nishikawa, K.,Shigeta, Y.,Sakurai, T.,Higuchi, Y.,Kataoka, K.,Shibata, N.	Redox Potential-Dependent Formation of an Unusual His-Trp Bond in Bilirubin Oxidase.	Chemistry	2018	24	18052	18058	
5ZHP	30404914	M3 muscarinic acetylcholine receptor in complex with a selective antagonist	2018-03-13	2018-11-28	Liu, H.,Hofmann, J.,Fish, I.,Schaake, B.,Eitel, K.,Bartuschat, A.,Kaindl, J.,Rampp, H.,Banerjee, A.,Hubner, H.,Clark, M.J.,Vincent, S.G.,Fisher, J.T.,Heinrich, M.R.,Hirata, K.,Liu, X.,Sunahara, R.K.,Shoichet, B.K.,Kobilka, B.K.,Gmeiner, P.	Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists	Proc. Natl. Acad. Sci. U.S.A.	2018	115	12046	12050	
5YHL	30510193	Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist Br-derivative	2017-09-28	2018-12-05	Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Yamashita, K.,Hirata, K.,Sekiguchi, Y.,Yasuda, S.,Shiroishi, M.,Shimizu, T.,Urushibata, Y.,Kajiwara, Y.,Inazumi, T.,Hotta, Y.,Asada, H.,Nakane, T.,Shiimura, Y.,Nakagita, T.,Tsuge, K.,Yoshida, S.,Kuribara, T.,Hosoya, T.,Sugimoto, Y.,Nomura, N.,Sato, M.,Hirokawa, T.,Kinoshita, M.,Murata, T.,Takayama, K.,Yamamoto, M.,Narumiya, S.,Iwata, S.,Kobayashi, T.	Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.	Nat. Chem. Biol.	2019	15	18	26	
5YWY	30510193	Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208	2017-11-30	2018-12-05	Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Yamashita, K.,Hirata, K.,Sekiguchi, Y.,Yasuda, S.,Shiroishi, M.,Shimizu, T.,Urushibata, Y.,Kajiwara, Y.,Inazumi, T.,Hotta, Y.,Asada, H.,Nakane, T.,Shiimura, Y.,Nakagita, T.,Tsuge, K.,Yoshida, S.,Kuribara, T.,Hosoya, T.,Sugimoto, Y.,Nomura, N.,Sato, M.,Hirokawa, T.,Kinoshita, M.,Murata, T.,Takayama, K.,Yamamoto, M.,Narumiya, S.,Iwata, S.,Kobayashi, T.	Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.	Nat. Chem. Biol.	2019	15	18	26	
6A33	30378729	Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA	2018-06-14	2018-12-05	Huang, W.C.,Liao, J.H.,Hsiao, T.C.,Wei, T.W.,Maestre-Reyna, M.,Bessho, Y.,Tsai, M.D.	Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.	Chembiochem	2019	20	140	146	
6AK3	30510192	Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2	2018-08-29	2018-12-05	Morimoto, K.,Suno, R.,Hotta, Y.,Yamashita, K.,Hirata, K.,Yamamoto, M.,Narumiya, S.,Iwata, S.,Kobayashi, T.	Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.	Nat. Chem. Biol.	2019	15	8	10	
6AAF	30451685	Crystal structure of fission yeast Atg8 complexed with the helical AIM of Hfl1.	2018-07-18	2018-12-12	Liu, X.M.,Yamasaki, A.,Du, X.M.,Coffman, V.C.,Ohsumi, Y.,Nakatogawa, H.,Wu, J.Q.,Noda, N.N.,Du, L.L.	Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein	Elife	2018	7	0	0	
6IJF	30511676	Crystal structure of the type VI effector-immunity complex (Tae4-Tai4) from Agrobacterium tumefaciens	2018-10-09	2018-12-19	Fukuhara, S.,Nakane, T.,Yamashita, K.,Ishii, R.,Ishitani, R.,Nureki, O.	Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.	Acta Crystallogr F Struct Biol	2018	74	810	816	
6AIT	30521812	Crystal structure of E. coli BepA	2018-08-24	2018-12-26	Shahrizal, M.,Daimon, Y.,Tanaka, Y.,Hayashi, Y.,Nakayama, S.,Iwaki, S.,Narita, S.I.,Kamikubo, H.,Akiyama, Y.,Tsukazaki, T.	Structural Basis for the Function of the beta-Barrel Assembly-Enhancing Protease BepA.	J. Mol. Biol.	2019	431	625	635	
6IDP	30449688	Crystal structure of Vibrio cholerae MATE transporter VcmN in the straight form	2018-09-11	2019-01-16	Kusakizako, T.,Claxton, D.P.,Tanaka, Y.,Maturana, A.D.,Kuroda, T.,Ishitani, R.,Mchaourab, H.S.,Nureki, O.	Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter.	Structure	2019	27	293	0	
6IDR	30449688	Crystal structure of Vibrio cholerae MATE transporter VcmN in the bent form	2018-09-11	2019-01-16	Kusakizako, T.,Claxton, D.P.,Tanaka, Y.,Maturana, A.D.,Kuroda, T.,Ishitani, R.,Mchaourab, H.S.,Nureki, O.	Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter.	Structure	2019	27	293	0	
6A76	30595454	Crystal structure of the Fab fragment of B5209B, a murine monoclonal antibody specific for the fifth immunoglobulin domain (Ig5) of human ROBO1	2018-07-02	2019-01-30	Yamashita, T.,Mizohata, E.,Nagatoishi, S.,Watanabe, T.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Nakayama, T.,Kado, Y.,Yokota, Y.,Matsumura, H.,Kawamura, T.,Kodama, T.,Hamakubo, T.,Inoue, T.,Fujitani, H.,Tsumoto, K.	Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface.	Structure	2019	27	519	0	
6IF5	30566863	Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate)	2018-09-18	2019-01-30	Zhang, Z.,Ohto, U.,Shibata, T.,Taoka, M.,Yamauchi, Y.,Sato, R.,Shukla, N.M.,David, S.A.,Isobe, T.,Miyake, K.,Shimizu, T.	Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.	Cell Rep	2018	25	3371	0	
6IU3	30742036	Crystal structure of iron transporter VIT1 with zinc ions	2018-11-27	2019-02-06	Kato, T.,Kumazaki, K.,Wada, M.,Taniguchi, R.,Nakane, T.,Yamashita, K.,Hirata, K.,Ishitani, R.,Ito, K.,Nishizawa, T.,Nureki, O.	Crystal structure of plant vacuolar iron transporter VIT1.	Nat Plants	2019	5	308	315	
6IU4	30742036	Crystal structure of iron transporter VIT1 with cobalt ion	2018-11-27	2019-02-06	Kato, T.,Kumazaki, K.,Wada, M.,Taniguchi, R.,Nakane, T.,Yamashita, K.,Hirata, K.,Ishitani, R.,Ito, K.,Nishizawa, T.,Nureki, O.	Crystal structure of plant vacuolar iron transporter VIT1.	Nat Plants	2019	5	308	315	
6A93	30723326	Crystal structure of 5-HT2AR in complex with risperidone	2018-07-11	2019-02-13	Kimura, K.T.,Asada, H.,Inoue, A.,Kadji, F.M.N.,Im, D.,Mori, C.,Arakawa, T.,Hirata, K.,Nomura, Y.,Nomura, N.,Aoki, J.,Iwata, S.,Shimamura, T.	Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.	Nat.Struct.Mol.Biol.	2019	26	121	128	
6A94	30723326	Crystal structure of 5-HT2AR in complex with zotepine	2018-07-11	2019-02-13	Kimura, K.T.,Asada, H.,Inoue, A.,Kadji, F.M.N.,Im, D.,Mori, C.,Arakawa, T.,Hirata, K.,Nomura, Y.,Nomura, N.,Aoki, J.,Iwata, S.,Shimamura, T.	Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.	Nat.Struct.Mol.Biol.	2019	26	121	128	
6AJ4	30853411	Crystal structure of the DHR-2 domain of DOCK7 in complex with Cdc42	2018-08-27	2019-03-20	Kukimoto-Niino, M.,Tsuda, K.,Ihara, K.,Mishima-Tsumagari, C.,Honda, K.,Ohsawa, N.,Shirouzu, M.	Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.	Structure	2019	27	741	0	
6AJL	30853411	DOCK7 mutant I1836Y complexed with Cdc42	2018-08-28	2019-03-20	Kukimoto-Niino, M.,Tsuda, K.,Ihara, K.,Mishima-Tsumagari, C.,Honda, K.,Ohsawa, N.,Shirouzu, M.	Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.	Structure	2019	27	741	0	
6AAC	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with mAzZLys	2018-07-18	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6AAN	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with mEtZLys	2018-07-18	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6AAQ	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with BCNLys	2018-07-18	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6AAZ	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pNO2ZLys	2018-07-19	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6AB0	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pAmPyLys	2018-07-19	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6AB1	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with oAzZLys	2018-07-19	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6ABK	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with TeocLys	2018-07-22	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6ABL	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with oBrZLys	2018-07-22	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6ABM	31031143	Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with pTmdZLys	2018-07-22	2019-04-17	Yanagisawa, T.,Kuratani, M.,Seki, E.,Hino, N.,Sakamoto, K.,Yokoyama, S.	Structural Basis for Genetic-Code Expansion with Bulky Lysine Derivatives by an Engineered Pyrrolysyl-tRNA Synthetase.	Cell Chem Biol	2019	26	936	0	
6JKC	31045564	Crystal structure of tetrameric PepTSo2 in P4212 space group	2019-02-28	2019-05-15	Nagamura, R.,Fukuda, M.,Kawamoto, A.,Matoba, K.,Dohmae, N.,Ishitani, R.,Takagi, J.,Nureki, O.	Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2.	Acta Crystallogr.,Sect.F	2019	75	348	358	
6JKD	31045564	Crystal structure of tetrameric PepTSo2 in I4 space group	2019-02-28	2019-05-15	Nagamura, R.,Fukuda, M.,Kawamoto, A.,Matoba, K.,Dohmae, N.,Ishitani, R.,Takagi, J.,Nureki, O.	Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2.	Acta Crystallogr.,Sect.F	2019	75	348	358	
5ZTF	31018135	Structure of Ca2+ ATPase	2018-05-03	2019-05-22	Inoue, M.,Sakuta, N.,Watanabe, S.,Zhang, Y.,Yoshikaie, K.,Tanaka, Y.,Ushioda, R.,Kato, Y.,Takagi, J.,Tsukazaki, T.,Nagata, K.,Inaba, K.	Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay.	Cell Rep	2019	27	1221	0	
5ZTF	31018135	Structure of Ca2+ ATPase	2018-05-03	2019-05-22	Inoue, M.,Sakuta, N.,Watanabe, S.,Zhang, Y.,Yoshikaie, K.,Tanaka, Y.,Ushioda, R.,Kato, Y.,Takagi, J.,Tsukazaki, T.,Nagata, K.,Inaba, K.	Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay.	Cell Rep	2019	27	1221	0	
5ZTF	31018135	Structure of Ca2+ ATPase	2018-05-03	2019-05-22	Inoue, M.,Sakuta, N.,Watanabe, S.,Zhang, Y.,Yoshikaie, K.,Tanaka, Y.,Ushioda, R.,Kato, Y.,Takagi, J.,Tsukazaki, T.,Nagata, K.,Inaba, K.	Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay.	Cell Rep	2019	27	1221	0	
6JJU	31018135	Structure of Ca2+ ATPase	2019-02-27	2019-05-22	Inoue, M.,Sakuta, N.,Watanabe, S.,Zhang, Y.,Yoshikaie, K.,Tanaka, Y.,Ushioda, R.,Kato, Y.,Takagi, J.,Tsukazaki, T.,Nagata, K.,Inaba, K.	Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay.	Cell Rep	2019	27	1221	0	
6AK8	31067051	Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Adenine and Incoming Ca-8oxodGTP	2018-08-30	2019-05-29	Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D.	Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.	J.Am.Chem.Soc.	2019	141	8489	8502	
6IPF	31067051	Post-catalytic Complex of Human DNA Polymerase Mu with Templating Cytosine and Mn-8oxodGMP	2018-11-03	2019-05-29	Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D.	Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.	J.Am.Chem.Soc.	2019	141	8489	8502	
6IPG	31067051	Post-catalytic Complex of Human DNA Polymerase Mu with Templating Cytosine and Mg-8oxodGMP	2018-11-03	2019-05-29	Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D.	Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.	J.Am.Chem.Soc.	2019	141	8489	8502	
6IPK	31067051	Binary Complex of Human DNA Polymerase Mu with Mn8oxodGTP	2018-11-03	2019-05-29	Chang, Y.K.,Huang, Y.P.,Liu, X.X.,Ko, T.P.,Bessho, Y.,Kawano, Y.,Maestre-Reyna, M.,Wu, W.J.,Tsai, M.D.	Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.	J.Am.Chem.Soc.	2019	141	8489	8502	
6E67	31080070	Structure of beta2 adrenergic receptor fused to a Gs peptide	2018-07-24	2019-06-05	Liu, X.,Xu, X.,Hilger, D.,Aschauer, P.,Tiemann, J.K.S.,Du, Y.,Liu, H.,Hirata, K.,Sun, X.,Guixa-Gonzalez, R.,Mathiesen, J.M.,Hildebrand, P.W.,Kobilka, B.K.	Structural Insights into the Process of GPCR-G Protein Complex Formation.	Cell	2019	177	1243	0	
6A15	31182839	Structure of CYP90B1 in complex with cholesterol	2018-06-06	2019-06-12	Fujiyama, K.,Hino, T.,Kanadani, M.,Watanabe, B.,Jae Lee, H.,Mizutani, M.,Nagano, S.	Structural insights into a key step of brassinosteroid biosynthesis and its inhibition.	Nat.Plants	2019	5	589	594	
6A16	31182839	Crystal structure of CYP90B1 in complex with uniconazole	2018-06-06	2019-06-12	Fujiyama, K.,Hino, T.,Kanadani, M.,Watanabe, B.,Jae Lee, H.,Mizutani, M.,Nagano, S.	Structural insights into a key step of brassinosteroid biosynthesis and its inhibition.	Nat.Plants	2019	5	589	594	
6A18	31182839	Crystal structure of CYP90B1 in complex with 1,6-hexandiol	2018-06-06	2019-06-12	Fujiyama, K.,Hino, T.,Kanadani, M.,Watanabe, B.,Jae Lee, H.,Mizutani, M.,Nagano, S.	Structural insights into a key step of brassinosteroid biosynthesis and its inhibition.	Nat.Plants	2019	5	589	594	
6J27	31162806	Crystal structure of the branched-chain polyamine synthase from Thermus thermophilus (Tth-BpsA) in complex with N4-aminopropylspermidine and 5'-methylthioadenosine	2018-12-31	2019-06-26	Hidese, R.,Toyoda, M.,Yoshino, K.I.,Fukuda, W.,Wihardja, G.A.,Kimura, S.,Fujita, J.,Niitsu, M.,Oshima, T.,Imanaka, T.,Mizohata, E.,Fujiwara, S.	The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis.	Febs J.	2019	286	3926	3940	
6JX3	31188556	Lasso peptide synthetase B1 complexed with the leader peptide	2019-04-22	2019-06-26	Sumida, T.,Dubiley, S.,Wilcox, B.,Severinov, K.,Tagami, S.	Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway.	Acs Chem.Biol.	2019	14	1619	1627	
6N48	31249059	Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator	2018-11-17	2019-06-26	Liu, X.,Masoudi, A.,Kahsai, A.W.,Huang, L.Y.,Pani, B.,Staus, D.P.,Shim, P.J.,Hirata, K.,Simhal, R.K.,Schwalb, A.M.,Rambarat, P.K.,Ahn, S.,Lefkowitz, R.J.,Kobilka, B.	Mechanism of beta2AR regulation by an intracellular positive allosteric modulator.	Science	2019	364	1283	1287	
6K1Q	31263780	Human endothelin receptor type-B in complex with inverse agonist IRL2500	2019-05-11	2019-07-17	Nagiri, C.,Shihoya, W.,Inoue, A.,Kadji, F.M.N.,Aoki, J.,Nureki, O.	Crystal structure of human endothelin ETBreceptor in complex with peptide inverse agonist IRL2500.	Commun Biol	2019	2	236	236	
6IS6	31554965	Crystal structure of Thermoplasmatales archaeon heliorhodopsin	2018-11-15	2019-09-25	Shihoya, W.,Inoue, K.,Singh, M.,Konno, M.,Hososhima, S.,Yamashita, K.,Ikeda, K.,Higuchi, A.,Izume, T.,Okazaki, S.,Hashimoto, M.,Mizutori, R.,Tomida, S.,Yamauchi, Y.,Abe-Yoshizumi, R.,Katayama, K.,Tsunoda, S.P.,Shibata, M.,Furutani, Y.,Pushkarev, A.,Beja, O.,Uchihashi, T.,Kandori, H.,Nureki, O.	Crystal structure of heliorhodopsin.	Nature	2019	574	132	136	
6JO0	31548428	Crystal structure of the DTS-motif rhodopsin from Phaeocystis globosa virus 12T	2019-03-19	2019-10-02	Needham, D.M.,Yoshizawa, S.,Hosaka, T.,Poirier, C.,Choi, C.J.,Hehenberger, E.,Irwin, N.A.T.,Wilken, S.,Yung, C.M.,Bachy, C.,Kurihara, R.,Nakajima, Y.,Kojima, K.,Kimura-Someya, T.,Leonard, G.,Malmstrom, R.R.,Mende, D.R.,Olson, D.K.,Sudo, Y.,Sudek, S.,Richards, T.A.,DeLong, E.F.,Keeling, P.J.,Santoro, A.E.,Shirouzu, M.,Iwasaki, W.,Worden, A.Z.	A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators.	Proc.Natl.Acad.Sci.USA	2019	116	20574	20583	
6OL9	31772027	Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium	2019-04-16	2019-12-11	Vuckovic, Z.,Gentry, P.R.,Berizzi, A.E.,Hirata, K.,Varghese, S.,Thompson, G.,van der Westhuizen, E.T.,Burger, W.A.C.,Rahmani, R.,Valant, C.,Langmead, C.J.,Lindsley, C.W.,Baell, J.B.,Tobin, A.B.,Sexton, P.M.,Christopoulos, A.,Thal, D.M.	Crystal structure of the M5muscarinic acetylcholine receptor.	Proc.Natl.Acad.Sci.USA	2019	116	26001	26007	
6KMD	31822504	Crystal structure of SeMet-phytochromobilin synthase from tomato in complex with biliverdin	2019-07-31	2019-12-18	Sugishima, M.,Wada, K.,Fukuyama, K.,Yamamoto, K.	Crystal structure of phytochromobilin synthase in complex with biliverdin IX alpha , a key enzyme in the biosynthesis of phytochrome.	J.Biol.Chem.	2020	295	771	782	
6KME	31822504	Crystal structure of phytochromobilin synthase from tomato in complex with biliverdin	2019-07-31	2019-12-18	Sugishima, M.,Wada, K.,Fukuyama, K.,Yamamoto, K.	Crystal structure of phytochromobilin synthase in complex with biliverdin IX alpha , a key enzyme in the biosynthesis of phytochrome.	J.Biol.Chem.	2020	295	771	782	
6JOD	31899086	Angiotensin II type 2 receptor with ligand	2019-03-20	2020-01-15	Asada, H.,Inoue, A.,Ngako Kadji, F.M.,Hirata, K.,Shiimura, Y.,Im, D.,Shimamura, T.,Nomura, N.,Iwanari, H.,Hamakubo, T.,Kusano-Arai, O.,Hisano, H.,Uemura, T.,Suno, C.,Aoki, J.,Iwata, S.	The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.	Structure	2020	28	418	0	
6K9Y	32005660	Crystal structure of human VAT-1	2019-06-19	2020-02-12	Watanabe, Y.,Tamura, Y.,Kakuta, C.,Watanabe, S.,Endo, T.	Structural basis for interorganelle phospholipid transport mediated by VAT-1.	J.Biol.Chem.	2020	295	3257	3268	
6LRY	32001000	Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b	2020-01-16	2020-02-12	Izume, T.,Miyauchi, H.,Shihoya, W.,Nureki, O.	Crystal structure of human endothelin ETBreceptor in complex with sarafotoxin S6b.	Biochem.Biophys.Res.Commun.	2020	528	383	388	
6KR6	32051406	Crystal structure of Drosophila Piwi	2019-08-21	2020-02-19	Yamaguchi, S.,Oe, A.,Nishida, K.M.,Yamashita, K.,Kajiya, A.,Hirano, S.,Matsumoto, N.,Dohmae, N.,Ishitani, R.,Saito, K.,Siomi, H.,Nishimasu, H.,Siomi, M.C.,Nureki, O.	Crystal structure of Drosophila Piwi.	Nat Commun	2020	11	858	858	
6LL5	32039890	Crystal structure of KpFtsZ (residues 11-316)	2019-12-21	2020-02-26	Yoshizawa, T.,Fujita, J.,Terakado, H.,Ozawa, M.,Kuroda, N.,Tanaka, S.I.,Uehara, R.,Matsumura, H.	Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli.	Acta Crystallogr.,Sect.F	2020	76	86	93	
6LL6	32039890	Crsyal structure of EcFtsZ (residues 11-316)	2019-12-21	2020-02-26	Yoshizawa, T.,Fujita, J.,Terakado, H.,Ozawa, M.,Kuroda, N.,Tanaka, S.I.,Uehara, R.,Matsumura, H.	Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli.	Acta Crystallogr.,Sect.F	2020	76	86	93	
6JO1	32157795	Structure of the CYP102A1 Haem Domain with N-(S)-Ibuprofenoyl-L-Phenylalanine	2019-03-19	2020-03-18	Stanfield, J.K.,Omura, K.,Matsumoto, A.,Kasai, C.,Sugimoto, H.,Shiro, Y.,Watanabe, Y.,Shoji, O.	Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain.	Angew.Chem.Int.Ed.Engl.	2020	59	7611	7618	
6K9S	32157795	Structure of the Carbonylruthenium Mesoporphyrin IX-Reconstituted CYP102A1 Haem Domain with N-Abietoyl-L-Tryptophan	2019-06-17	2020-03-18	Stanfield, J.K.,Omura, K.,Matsumoto, A.,Kasai, C.,Sugimoto, H.,Shiro, Y.,Watanabe, Y.,Shoji, O.	Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain.	Angew.Chem.Int.Ed.Engl.	2020	59	7611	7618	
6OBA	32483378	The beta2 adrenergic receptor bound to a negative allosteric modulator	2019-03-20	2020-03-25	Liu, X.,Kaindl, J.,Korczynska, M.,Stossel, A.,Dengler, D.,Stanek, M.,Hubner, H.,Clark, M.J.,Mahoney, J.,Matt, R.A.,Xu, X.,Hirata, K.,Shoichet, B.K.,Sunahara, R.K.,Kobilka, B.K.,Gmeiner, P.	An allosteric modulator binds to a conformational hub in the beta2adrenergic receptor.	Nat.Chem.Biol.	2020	16	749	755	
6JZK	32284566	Structure of FimA type-1 (FimA1) prepilin of the type V major fimbrium	2019-05-02	2020-04-15	Shibata, S.,Shoji, M.,Okada, K.,Matsunami, H.,Matthews, M.M.,Imada, K.,Nakayama, K.,Wolf, M.	Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange.	Nat Microbiol	2020	5	830	837	
6LR7	32277083	Crystal structure of GFPuv complexed with the nanobody LaG16 at 1.67 Angstron resolution	2020-01-15	2020-04-29	Zhang, Z.,Wang, Y.,Ding, Y.,Hattori, M.	Structure-based engineering of anti-GFP nanobody tandems as ultra-high-affinity reagents for purification.	Sci Rep	2020	10	6239	6239	
6K4J	32231207	Crystal Structure of the the CD9	2019-05-24	2020-05-13	Umeda, R.,Satouh, Y.,Takemoto, M.,Nakada-Nakura, Y.,Liu, K.,Yokoyama, T.,Shirouzu, M.,Iwata, S.,Nomura, N.,Sato, K.,Ikawa, M.,Nishizawa, T.,Nureki, O.	Structural insights into tetraspanin CD9 function.	Nat Commun	2020	11	1606	1606	
6KCS	31960921	Crystal structure of HIRAN domain of HLTF in complex with duplex DNA	2019-06-28	2020-06-10	Hishiki, A.,Sato, M.,Hashimoto, H.	Structure of HIRAN domain of human HLTF bound to duplex DNA provides structural basis for DNA unwinding to initiate replication fork regression.	J.Biochem.	2020	167	597	602	
6LYA	32484330	PylRS C-terminus domain mutant bound with 1-Methyl-L-tryptophan and AMPNP	2020-02-13	2020-07-08	Jiang, H.K.,Wang, Y.H.,Weng, J.H.,Kurkute, P.,Li, C.L.,Lee, M.N.,Chen, P.J.,Tseng, H.W.,Tsai, M.D.,Wang, Y.S.	Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues.	Biochemistry	2020	59	2205	2209	
7BRQ	32620754	Crystal structure of human FAM134B LIR fused to human GABARAP	2020-03-29	2020-07-08	Mochida, K.,Yamasaki, A.,Matoba, K.,Kirisako, H.,Noda, N.N.,Nakatogawa, H.	Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.	Nat Commun	2020	11	3306	3306	
7BRU	32620754	Crystal structure of human RTN3 LIR fused to human GABARAP	2020-03-30	2020-07-08	Mochida, K.,Yamasaki, A.,Matoba, K.,Kirisako, H.,Noda, N.N.,Nakatogawa, H.	Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.	Nat Commun	2020	11	3306	3306	
7C61	32669569	Crystal structure of 5-HT1B-BRIL and SRP2070_Fab complex	2020-05-21	2020-07-29	Miyagi, H.,Asada, H.,Suzuki, M.,Takahashi, Y.,Yasunaga, M.,Suno, C.,Iwata, S.,Saito, J.I.	The discovery of a new antibody for BRIL-fused GPCR structure determination.	Sci Rep	2020	10	11669	11669	
7C6A	32669569	Crystal structure of AT2R-BRIL and SRP2070_Fab complex	2020-05-21	2020-07-29	Miyagi, H.,Asada, H.,Suzuki, M.,Takahashi, Y.,Yasunaga, M.,Suno, C.,Iwata, S.,Saito, J.I.	The discovery of a new antibody for BRIL-fused GPCR structure determination.	Sci Rep	2020	10	11669	11669	
6KO5	32814772	Complex structure of Ghrelin receptor with Fab	2019-08-08	2020-08-12	Shiimura, Y.,Horita, S.,Hamamoto, A.,Asada, H.,Hirata, K.,Tanaka, M.,Mori, K.,Uemura, T.,Kobayashi, T.,Iwata, S.,Kojima, M.	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode.	Nat Commun	2020	11	4160	4160	
6KS2	32814772	Structure of anti-Ghrelin receptor antibody	2019-08-23	2020-08-12	Shiimura, Y.,Horita, S.,Hamamoto, A.,Asada, H.,Hirata, K.,Tanaka, M.,Mori, K.,Uemura, T.,Kobayashi, T.,Iwata, S.,Kojima, M.	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode.	Nat Commun	2020	11	4160	4160	
6KRZ	32796916	Crystal structure of the human adiponectin receptor 1 D208A mutant	2019-08-22	2020-08-19	Tanabe, H.,Fujii, Y.,Okada-Iwabu, M.,Iwabu, M.,Kano, K.,Kawana, H.,Hato, M.,Nakamura, Y.,Terada, T.,Kimura-Someya, T.,Shirouzu, M.,Kawano, Y.,Yamamoto, M.,Aoki, J.,Yamauchi, T.,Kadowaki, T.,Yokoyama, S.	Human adiponectin receptor AdipoR1 assumes closed and open structures.	Commun Biol	2020	3	446	446	
6KS0	32796916	Crystal structure of the human adiponectin receptor 1	2019-08-22	2020-08-19	Tanabe, H.,Fujii, Y.,Okada-Iwabu, M.,Iwabu, M.,Kano, K.,Kawana, H.,Hato, M.,Nakamura, Y.,Terada, T.,Kimura-Someya, T.,Shirouzu, M.,Kawano, Y.,Yamamoto, M.,Aoki, J.,Yamauchi, T.,Kadowaki, T.,Yokoyama, S.	Human adiponectin receptor AdipoR1 assumes closed and open structures.	Commun Biol	2020	3	446	446	
6KS1	32796916	Crystal structure of the human adiponectin receptor 2	2019-08-22	2020-08-19	Tanabe, H.,Fujii, Y.,Okada-Iwabu, M.,Iwabu, M.,Kano, K.,Kawana, H.,Hato, M.,Nakamura, Y.,Terada, T.,Kimura-Someya, T.,Shirouzu, M.,Kawano, Y.,Yamamoto, M.,Aoki, J.,Yamauchi, T.,Kadowaki, T.,Yokoyama, S.	Human adiponectin receptor AdipoR1 assumes closed and open structures.	Commun Biol	2020	3	446	446	
7BUR	32725893	Chalcone synthase from Glycine max (L.) Merr (soybean) complexed with naringenin	2020-04-08	2020-08-19	Imaizumi, R.,Mameda, R.,Takeshita, K.,Kubo, H.,Sakai, N.,Nakata, S.,Takahashi, S.,Kataoka, K.,Yamamoto, M.,Nakayama, T.,Yamashita, S.,Waki, T.	Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean.	Proteins	2020	0	0	0	
7BUS	32725893	Chalcone synthase from Glycine max (L.) Merr (soybean)	2020-04-08	2020-08-19	Imaizumi, R.,Mameda, R.,Takeshita, K.,Kubo, H.,Sakai, N.,Nakata, S.,Takahashi, S.,Kataoka, K.,Yamamoto, M.,Nakayama, T.,Yamashita, S.,Waki, T.	Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean.	Proteins	2020	0	0	0	
6L63	32839601	Human Coagulation Factor XIIa (FXIIa) bound with the macrocyclic peptide F3 containing two (1S,2S)-2-ACHC residues	2019-10-26	2020-09-02	Katoh, T.,Sengoku, T.,Hirata, K.,Ogata, K.,Suga, H.	Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic beta-amino acids.	Nat.Chem.	2020	12	1081	1088	
6LEO	32923628	Crystal structure of thiosulfate transporter YeeE from Spirochaeta thermophila	2019-11-26	2020-09-02	Tanaka, Y.,Yoshikaie, K.,Takeuchi, A.,Ichikawa, M.,Mori, T.,Uchino, S.,Sugano, Y.,Hakoshima, T.,Takagi, H.,Nonaka, G.,Tsukazaki, T.	Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake.	Sci Adv	2020	6	0	0	
6LEP	32923628	Crystal structure of thiosulfate transporter YeeE inactive mutant - C91A	2019-11-26	2020-09-02	Tanaka, Y.,Yoshikaie, K.,Takeuchi, A.,Ichikawa, M.,Mori, T.,Uchino, S.,Sugano, Y.,Hakoshima, T.,Takagi, H.,Nonaka, G.,Tsukazaki, T.	Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake.	Sci Adv	2020	6	0	0	
7CLJ	32951839	Crystal structure of Thermoplasmatales archaeon heliorhodopsin E108D mutant	2020-07-21	2020-09-02	Tanaka, T.,Singh, M.,Shihoya, W.,Yamashita, K.,Kandori, H.,Nureki, O.	Structural basis for unique color tuning mechanism in heliorhodopsin.	Biochem.Biophys.Res.Commun.	2020	533	262	267	
6M20	32860739	Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose	2020-02-26	2020-09-09	Jiang, X.,Yuan, Y.,Huang, J.,Zhang, S.,Luo, S.,Wang, N.,Pu, D.,Zhao, N.,Tang, Q.,Hirata, K.,Yang, X.,Jiao, Y.,Sakata-Kato, T.,Wu, J.W.,Yan, C.,Kato, N.,Yin, H.,Yan, N.	Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.	Cell	2020	183	258	0	
6M2L	32860739	Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with C3361	2020-02-27	2020-09-09	Jiang, X.,Yuan, Y.,Huang, J.,Zhang, S.,Luo, S.,Wang, N.,Pu, D.,Zhao, N.,Tang, Q.,Hirata, K.,Yang, X.,Jiao, Y.,Sakata-Kato, T.,Wu, J.W.,Yan, C.,Kato, N.,Yin, H.,Yan, N.	Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.	Cell	2020	183	258	0	
6L1A		Crystal Structure of P450BM3 with N-enanthoyl-L-prolyl-L-phenylalanine	2019-09-28	2020-09-30	Yonemura, K.,Ariyasu, S.,Stanfield, J.K.,Suzuki, K.,Onoda, H.,Kasai, C.,Sugimoto, H.,Aiba, Y.,Watanabe, Y.,Shoji, O.	Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3	Acs Catalysis	2020	10	9136	9144	
6LM0	33028840	The crystal structure of cyanorhodopsin (CyR) N2098R from cyanobacteria Calothrix sp. NIES-2098	2019-12-24	2020-10-21	Hasegawa, M.,Hosaka, T.,Kojima, K.,Nishimura, Y.,Nakajima, Y.,Kimura-Someya, T.,Shirouzu, M.,Sudo, Y.,Yoshizawa, S.	A unique clade of light-driven proton-pumping rhodopsins evolved in the cyanobacterial lineage.	Sci Rep	2020	10	16752	16752	
6LM1	33028840	The crystal structure of cyanorhodopsin (CyR) N4075R from cyanobacteria Tolypothrix sp. NIES-4075	2019-12-24	2020-10-21	Hasegawa, M.,Hosaka, T.,Kojima, K.,Nishimura, Y.,Nakajima, Y.,Kimura-Someya, T.,Shirouzu, M.,Sudo, Y.,Yoshizawa, S.	A unique clade of light-driven proton-pumping rhodopsins evolved in the cyanobacterial lineage.	Sci Rep	2020	10	16752	16752	
6M5E	33183011	Human serum albumin with cyclic peptide dalbavancin	2020-03-10	2020-11-18	Ito, S.,Senoo, A.,Nagatoishi, S.,Ohue, M.,Yamamoto, M.,Tsumoto, K.,Wakui, N.	Structural Basis for the Binding Mechanism of Human Serum Albumin Complexed with Cyclic Peptide Dalbavancin.	J.Med.Chem.	2020	63	14045	14053	
7D7P	33154353	Crystal structure of the phosphodiesterase domain of Salpingoeca rosetta rhodopsin phosphodiesterase	2020-10-05	2020-11-18	Ikuta, T.,Shihoya, W.,Sugiura, M.,Yoshida, K.,Watari, M.,Tokano, T.,Yamashita, K.,Katayama, K.,Tsunoda, S.P.,Uchihashi, T.,Kandori, H.,Nureki, O.	Structural insights into the mechanism of rhodopsin phosphodiesterase.	Nat Commun	2020	11	5605	5605	
7D7Q	33154353	Crystal structure of the transmembrane domain and linker region of Salpingoeca rosetta rhodopsin phosphodiesterase	2020-10-05	2020-11-18	Ikuta, T.,Shihoya, W.,Sugiura, M.,Yoshida, K.,Watari, M.,Tokano, T.,Yamashita, K.,Katayama, K.,Tsunoda, S.P.,Uchihashi, T.,Kandori, H.,Nureki, O.	Structural insights into the mechanism of rhodopsin phosphodiesterase.	Nat Commun	2020	11	5605	5605	
6LPL	33168855	A2AR crystallized in EROCOC17+4, SS-ROX at 100 K	2020-01-11	2020-11-25	Ihara, K.,Hato, M.,Nakane, T.,Yamashita, K.,Kimura-Someya, T.,Hosaka, T.,Ishizuka-Katsura, Y.,Tanaka, R.,Tanaka, T.,Sugahara, M.,Hirata, K.,Yamamoto, M.,Nureki, O.,Tono, K.,Nango, E.,Iwata, S.,Shirouzu, M.	Isoprenoid-chained lipid EROCOC 17+4 : a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography.	Sci Rep	2020	10	19305	19305	
7CJ3	33154353	Crystal structure of the transmembrane domain of Salpingoeca rosetta rhodopsin phosphodiesterase	2020-07-09	2020-11-25	Ikuta, T.,Shihoya, W.,Sugiura, M.,Yoshida, K.,Watari, M.,Tokano, T.,Yamashita, K.,Katayama, K.,Tsunoda, S.P.,Uchihashi, T.,Kandori, H.,Nureki, O.	Structural insights into the mechanism of rhodopsin phosphodiesterase.	Nat Commun	2020	11	5605	5605	
7BTS	33093660	Structure of human beta1 adrenergic receptor bound to epinephrine and nanobody 6B9	2020-04-02	2020-12-02	Xu, X.,Kaindl, J.,Clark, M.J.,Hubner, H.,Hirata, K.,Sunahara, R.K.,Gmeiner, P.,Kobilka, B.K.,Liu, X.	Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.	Cell Res.	2021	31	569	579	
7BU6	33093660	Structure of human beta1 adrenergic receptor bound to norepinephrine and nanobody 6B9	2020-04-04	2020-12-02	Xu, X.,Kaindl, J.,Clark, M.J.,Hubner, H.,Hirata, K.,Sunahara, R.K.,Gmeiner, P.,Kobilka, B.K.,Liu, X.	Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.	Cell Res.	2021	31	569	579	
7BU7	33093660	Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9	2020-04-04	2020-12-02	Xu, X.,Kaindl, J.,Clark, M.J.,Hubner, H.,Hirata, K.,Sunahara, R.K.,Gmeiner, P.,Kobilka, B.K.,Liu, X.	Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.	Cell Res.	2021	31	569	579	
7BVQ	33093660	Structure of human beta1 adrenergic receptor bound to carazolol	2020-04-11	2020-12-02	Xu, X.,Kaindl, J.,Clark, M.J.,Hubner, H.,Hirata, K.,Sunahara, R.K.,Gmeiner, P.,Kobilka, B.K.,Liu, X.	Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.	Cell Res.	2021	31	569	579	
6LEE		Crystal structure of Cypovirus Polyhedra mutant with deletion of Ala67-Ala104	2019-11-25	2020-12-09	Nguyen, T.K.,Abe, S.,Kasamatsu, M.,Maity, B.,Yamashita, K.,Hirata, K.,Kojima, M.,Ueno, T.	In-Cell Engineering of Protein Crystals with Nanoporous Structures for Promoting Cascade Reactions	ACS Appl Nano Mater	2021	4	1672	1681	
6LKD	33542467	in meso full-length rat KMO in complex with a pyrazoyl benzoic acid inhibitor	2019-12-19	2020-12-23	Mimasu, S.,Yamagishi, H.,Kubo, S.,Kiyohara, M.,Matsuda, T.,Yahata, T.,Thomson, H.A.,Hupp, C.D.,Liu, J.,Okuda, T.,Kakefuda, K.	Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.	Commun Biol	2021	4	159	159	
6LKE	33542467	in meso full-length rat KMO in complex with an inhibitor identified via DNA-encoded chemical library screening	2019-12-19	2020-12-23	Mimasu, S.,Yamagishi, H.,Kubo, S.,Kiyohara, M.,Matsuda, T.,Yahata, T.,Thomson, H.A.,Hupp, C.D.,Liu, J.,Okuda, T.,Kakefuda, K.	Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.	Commun Biol	2021	4	159	159	
7CRZ	33402433	Crystal structure of human glucose transporter GLUT3 bound with C3361	2020-08-14	2021-01-13	Huang, J.,Yuan, Y.,Zhao, N.,Pu, D.,Tang, Q.,Zhang, S.,Luo, S.,Yang, X.,Wang, N.,Xiao, Y.,Zhang, T.,Liu, Z.,Sakata-Kato, T.,Jiang, X.,Kato, N.,Yan, N.,Yin, H.	Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7CFF	33568487	Structure of the thermostabilized transmembrane domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with Mg2+	2020-06-25	2021-02-24	Huang, Y.,Jin, F.,Funato, Y.,Xu, Z.,Zhu, W.,Wang, J.,Sun, M.,Zhao, Y.,Yu, Y.,Miki, H.,Hattori, M.	Structural basis for the Mg 2+ recognition and regulation of the CorC Mg 2+ transporter.	Sci Adv	2021	7	0	0	
7CFG	33568487	Structure of the transmembrane domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with Mg2+	2020-06-25	2021-02-24	Huang, Y.,Jin, F.,Funato, Y.,Xu, Z.,Zhu, W.,Wang, J.,Sun, M.,Zhao, Y.,Yu, Y.,Miki, H.,Hattori, M.	Structural basis for the Mg 2+ recognition and regulation of the CorC Mg 2+ transporter.	Sci Adv	2021	7	0	0	
7CFH	33568487	Structure of the CBS domain of the bacterial CNNM/CorC family Mg2+ transporter	2020-06-25	2021-02-24	Huang, Y.,Jin, F.,Funato, Y.,Xu, Z.,Zhu, W.,Wang, J.,Sun, M.,Zhao, Y.,Yu, Y.,Miki, H.,Hattori, M.	Structural basis for the Mg 2+ recognition and regulation of the CorC Mg 2+ transporter.	Sci Adv	2021	7	0	0	
7CFI	33568487	Structure of the CBS domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with ATP	2020-06-25	2021-02-24	Huang, Y.,Jin, F.,Funato, Y.,Xu, Z.,Zhu, W.,Wang, J.,Sun, M.,Zhao, Y.,Yu, Y.,Miki, H.,Hattori, M.	Structural basis for the Mg 2+ recognition and regulation of the CorC Mg 2+ transporter.	Sci Adv	2021	7	0	0	
7E4G	33790007	Crystal structure of schizorhodopsin 4	2021-02-12	2021-02-24	Higuchi, A.,Shihoya, W.,Konno, M.,Ikuta, T.,Kandori, H.,Inoue, K.,Nureki, O.	Crystal structure of schizorhodopsin reveals mechanism of inward proton pumping.	Proc.Natl.Acad.Sci.USA	2021	118	0	0	
7CD1	33166654	Crystal structure of inhibitory Smad, Smad7	2020-06-18	2021-03-17	Murayama, K.,Kato-Murayama, M.,Itoh, Y.,Miyazono, K.,Miyazawa, K.,Shirouzu, M.	Structural basis for inhibitory effects of Smad7 on TGF-beta family signaling.	J.Struct.Biol.	2020	212	107661	107661	
7C4S	34108205	Sphingosine-1-phosphate receptor 3 with a natural ligand.	2020-05-18	2021-06-09	Maeda, S.,Shiimura, Y.,Asada, H.,Hirata, K.,Luo, F.,Nango, E.,Tanaka, N.,Toyomoto, M.,Inoue, A.,Aoki, J.,Iwata, S.,Hagiwara, M.	Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.	Sci Adv	2021	7	0	0	
7DQK	34050946	A nicotine MATE transporter, Nicotiana tabacum MATE2 (NtMATE2)	2020-12-24	2021-06-09	Tanaka, Y.,Iwaki, S.,Sasaki, A.,Tsukazaki, T.	Crystal structures of a nicotine MATE transporter provide insight into its mechanism of substrate transport.	Febs Lett.	2021	595	1902	1913	
7E5T	34121297	Crystal structure of Fsa2	2021-02-20	2021-06-30	Fujiyama, K.,Kato, N.,Re, S.,Kinugasa, K.,Watanabe, K.,Takita, R.,Nogawa, T.,Hino, T.,Osada, H.,Sugita, Y.,Takahashi, S.,Nagano, S.	Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*.	Angew.Chem.Int.Ed.Engl.	2021	60	22401	22410	
7E5U	34121297	Crystal structure of Phm7	2021-02-20	2021-06-30	Fujiyama, K.,Kato, N.,Re, S.,Kinugasa, K.,Watanabe, K.,Takita, R.,Nogawa, T.,Hino, T.,Osada, H.,Sugita, Y.,Takahashi, S.,Nagano, S.	Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*.	Angew.Chem.Int.Ed.Engl.	2021	60	22401	22410	
7E5V	34121297	Crystal structure of Phm7 in complex with inhibitor	2021-02-20	2021-06-30	Fujiyama, K.,Kato, N.,Re, S.,Kinugasa, K.,Watanabe, K.,Takita, R.,Nogawa, T.,Hino, T.,Osada, H.,Sugita, Y.,Takahashi, S.,Nagano, S.	Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*.	Angew.Chem.Int.Ed.Engl.	2021	60	22401	22410	
7CVR		Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with (S)-1-Tetralylamine	2020-08-26	2021-09-01	Shoji, O.,Stanfield, J.K.	Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with (S)-1-Tetralylamine at 1.60 Angstrom Resolution	To Be Published	0	0	0	0	
7E9S	34354228	Archaeal oligosaccharyltransferase AglB from Archaeoglobus fulgidus in complex with an inhibitory peptide and a dolichol-phosphate	2021-03-05	2021-09-08	Taguchi, Y.,Yamasaki, T.,Ishikawa, M.,Kawasaki, Y.,Yukimura, R.,Mitani, M.,Hirata, K.,Kohda, D.	The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon.	Commun Biol	2021	4	941	941	
7COO		Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with Cyclohexylamine	2020-08-04	2021-09-15	Shoji, O.,Stanfield, J.K.	Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with Cyclohexylamine at 1.49 Angstrom Resolution	To Be Published	0	0	0	0	
7D0U		Structure of the CYP102A1 Haem Domain with N-enanthyl-L-prolyl-L-phenylalanine in complex with Ethylamine	2020-09-11	2021-09-15	Shoji, O.,Stanfield, J.K.	Structure of the CYP102A1 Haem Domain with N-enanthyl-L-prolyl-L-phenylalanine in complex with Ethylamine at 1.68 Angstrom Resolution	To Be Published	0	0	0	0	
7DVH	34559526	Crystal structure of the computationally designed reDPBB_sym4 protein	2021-01-13	2021-09-29	Yagi, S.,Padhi, A.K.,Vucinic, J.,Barbe, S.,Schiex, T.,Nakagawa, R.,Simoncini, D.,Zhang, K.Y.J.,Tagami, S.	Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.	J.Am.Chem.Soc.	2021	143	15998	16006	
7D9Z	34625749	Crystal structure of anti-basigin Fab fragment	2020-10-14	2021-10-20	Sakuragi, T.,Kanai, R.,Tsutsumi, A.,Narita, H.,Onishi, E.,Nishino, K.,Miyazaki, T.,Baba, T.,Kosako, H.,Nakagawa, A.,Kikkawa, M.,Toyoshima, C.,Nagata, S.	The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes.	Nat.Struct.Mol.Biol.	2021	28	825	834	
7DAA	34625749	Crystal structure of basigin complexed with anti-basigin Fab fragment	2020-10-16	2021-10-20	Sakuragi, T.,Kanai, R.,Tsutsumi, A.,Narita, H.,Onishi, E.,Nishino, K.,Miyazaki, T.,Baba, T.,Kosako, H.,Nakagawa, A.,Kikkawa, M.,Toyoshima, C.,Nagata, S.	The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes.	Nat.Struct.Mol.Biol.	2021	28	825	834	
7VES	34753804	Crystal Structure of nucleotide-free Irgb6	2021-09-10	2021-11-03	Saijo-Hamano, Y.,Sherif, A.A.,Pradipta, A.,Sasai, M.,Sakai, N.,Sakihama, Y.,Yamamoto, M.,Standley, D.M.,Nitta, R.	Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.	Life Sci Alliance	2022	5	0	0	
7VEX	34753804	Crystal Structure of GTP-bound Irgb6	2021-09-10	2021-11-03	Saijo-Hamano, Y.,Sherif, A.A.,Pradipta, A.,Sasai, M.,Sakai, N.,Sakihama, Y.,Yamamoto, M.,Standley, D.M.,Nitta, R.	Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.	Life Sci Alliance	2022	5	0	0	
7FBP	34723512	FXIIa-cMCoFx1 complex	2021-07-12	2021-11-10	Liu, W.,de Veer, S.J.,Huang, Y.H.,Sengoku, T.,Okada, C.,Ogata, K.,Zdenek, C.N.,Fry, B.G.,Swedberg, J.E.,Passioura, T.,Craik, D.J.,Suga, H.	An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold.	J.Am.Chem.Soc.	2021	143	18481	18489	
7E3E	33759310	Crystal structure of Trypanosoma brucei cathepsin B R91C/T223C mutant	2021-02-08	2021-12-15	Abe, S.,Pham, T.T.,Negishi, H.,Yamashita, K.,Hirata, K.,Ueno, T.	Design of an In-Cell Protein Crystal for the Environmentally Responsive Construction of a Supramolecular Filament.	Angew.Chem.Int.Ed.Engl.	2021	60	12341	12345	
7E3F	33759310	Crystal structure of Trypanosoma brucei cathepsin B Y217C/S275C mutant	2021-02-08	2021-12-15	Abe, S.,Pham, T.T.,Negishi, H.,Yamashita, K.,Hirata, K.,Ueno, T.	Design of an In-Cell Protein Crystal for the Environmentally Responsive Construction of a Supramolecular Filament.	Angew.Chem.Int.Ed.Engl.	2021	60	12341	12345	
7E3G	33759310	Crystal structure of Trypanosoma brucei cathepsin B R91C/T223C mutant in the living cell	2021-02-08	2021-12-15	Abe, S.,Pham, T.T.,Negishi, H.,Yamashita, K.,Hirata, K.,Ueno, T.	Design of an In-Cell Protein Crystal for the Environmentally Responsive Construction of a Supramolecular Filament.	Angew.Chem.Int.Ed.Engl.	2021	60	12341	12345	
7ECD	34964897	Crystal structure of Tam41 from Firmicutes bacterium, complex with CTP-Mg	2021-03-12	2022-01-19	Kimura, K.,Kawai, F.,Kubota-Kawai, H.,Watanabe, Y.,Tomii, K.,Kojima, R.,Hirata, K.,Yamamori, Y.,Endo, T.,Tamura, Y.	Crystal structure of Tam41 cytidine diphosphate diacylglycerol synthase from a Firmicutes bacterium.	J.Biochem.	2022	171	429	441	
7EJN	34857854	Complex Structure of HLA-A*2402 with the Peptide from HCoV(CoV-HKU1) spike protein	2021-04-02	2022-01-26	Shimizu, K.,Iyoda, T.,Sanpei, A.,Nakazato, H.,Okada, M.,Ueda, S.,Kato-Murayama, M.,Murayama, K.,Shirouzu, M.,Harada, N.,Hidaka, M.,Fujii, S.I.	Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2.	Commun Biol	2021	4	1365	1365	
7WEW		Structure of adenylation domain of epsilon-poly-L-lysine synthase	2021-12-24	2022-02-09	Okamoto, T.,Yamanaka, K.,Hamano, Y.,Nagano, S.,Hino, T.	Crystal structure of the adenylation domain from an epsilon-poly-l-lysine synthetase provides molecular mechanism for substrate specificity	Biochem.Biophys.Res.Commun.	2022	596	43	48	
7VWS	35235232	Carbazole Prenyl Transferase LvqB4	2021-11-11	2022-03-23	Nagata, R.,Suemune, H.,Kobayashi, M.,Shinada, T.,Shin-Ya, K.,Nishiyama, M.,Hino, T.,Sato, Y.,Kuzuyama, T.,Nagano, S.	Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7VWT	35235232	Carbazole Prenyl Transferase CqsB4	2021-11-11	2022-03-23	Nagata, R.,Suemune, H.,Kobayashi, M.,Shinada, T.,Shin-Ya, K.,Nishiyama, M.,Hino, T.,Sato, Y.,Kuzuyama, T.,Nagano, S.	Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes.	Angew.Chem.Int.Ed.Engl.	2022	61	0	0	
7WBT	35090055	Crystal structure of bovine NLRP9	2021-12-17	2022-04-06	Kamitsukasa, Y.,Nakano, K.,Murakami, K.,Hirata, K.,Yamamoto, M.,Shimizu, T.,Ohto, U.	The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.	Febs Lett.	2022	596	876	885	
7EQE	35429224	Crystal Structure of a transcription factor	2021-05-01	2022-04-27	Tsugita, A.,Uehara, S.,Matsui, T.,Yokoyama, T.,Ostash, I.,Deneka, M.,Yalamanchili, S.,Bennett, C.S.,Tanaka, Y.,Ostash, B.	The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK.	Febs J.	2022	289	6038	6057	
7SPS	35552392	Crystal structure of human glucose transporter GLUT3 bound with exofacial inhibitor SA47	2021-11-03	2022-05-18	Wang, N.,Zhang, S.,Yuan, Y.,Xu, H.,Defossa, E.,Matter, H.,Besenius, M.,Derdau, V.,Dreyer, M.,Halland, N.,He, K.H.,Petry, S.,Podeschwa, M.,Tennagels, N.,Jiang, X.,Yan, N.	Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.	Nat Commun	2022	13	2632	2632	
7SPT	35552392	Crystal structure of exofacial state human glucose transporter GLUT3	2021-11-03	2022-05-18	Wang, N.,Zhang, S.,Yuan, Y.,Xu, H.,Defossa, E.,Matter, H.,Besenius, M.,Derdau, V.,Dreyer, M.,Halland, N.,He, K.H.,Petry, S.,Podeschwa, M.,Tennagels, N.,Jiang, X.,Yan, N.	Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.	Nat Commun	2022	13	2632	2632	
7VPC	35133719	Neryl diphosphate synthase from Solanum lycopersicum	2021-10-15	2022-05-18	Kutsukawa, R.,Imaizumi, R.,Suenaga-Hiromori, M.,Takeshita, K.,Sakai, N.,Misawa, S.,Yamamoto, M.,Yamaguchi, H.,Miyagi-Inoue, Y.,Waki, T.,Kataoka, K.,Nakayama, T.,Yamashita, S.,Takahashi, S.	Structure-based engineering of a short-chain cis-prenyltransferase to biosynthesize nonnatural all-cis-polyisoprenoids: molecular mechanisms for primer substrate recognition and ultimate product chain-length determination.	Febs J.	2022	289	4602	4621	
7X7O	35543180	SARS-CoV-2 spike RBD in complex with neutralizing antibody UT28K	2022-03-10	2022-05-25	Ozawa, T.,Tani, H.,Anraku, Y.,Kita, S.,Igarashi, E.,Saga, Y.,Inasaki, N.,Kawasuji, H.,Yamada, H.,Sasaki, S.I.,Somekawa, M.,Sasaki, J.,Hayakawa, Y.,Yamamoto, Y.,Morinaga, Y.,Kurosawa, N.,Isobe, M.,Fukuhara, H.,Maenaka, K.,Hashiguchi, T.,Kishi, H.,Kitajima, I.,Saito, S.,Niimi, H.	Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants.	Mabs	2022	14	2072455	2072455	
7WAG	35660157	Crystal structure of MurJ squeezed form	2021-12-14	2022-06-01	Kohga, H.,Mori, T.,Tanaka, Y.,Yoshikaie, K.,Taniguchi, K.,Fujimoto, K.,Fritz, L.,Schneider, T.,Tsukazaki, T.	Crystal structure of the lipid flippase MurJ in a ""squeezed"" form distinct from its inward- and outward-facing forms.	Structure	2022	30	1088	0	
7WAW	35660157	MurJ inward closed form	2021-12-15	2022-06-01	Kohga, H.,Mori, T.,Tanaka, Y.,Yoshikaie, K.,Taniguchi, K.,Fujimoto, K.,Fritz, L.,Schneider, T.,Tsukazaki, T.	Crystal structure of the lipid flippase MurJ in a ""squeezed"" form distinct from its inward- and outward-facing forms.	Structure	2022	30	1088	0	
7WAX	35660157	MurJ inward occluded form	2021-12-15	2022-06-01	Kohga, H.,Mori, T.,Tanaka, Y.,Yoshikaie, K.,Taniguchi, K.,Fujimoto, K.,Fritz, L.,Schneider, T.,Tsukazaki, T.	Crystal structure of the lipid flippase MurJ in a ""squeezed"" form distinct from its inward- and outward-facing forms.	Structure	2022	30	1088	0	
7F0V		Structure of the M305I mutant of CueO	2021-06-07	2022-06-15	Kawano, T.K.,Takata, S.T.,Sakai, N.S.,Imaizumi, R.I.,Nakata, S.N.,Takeshita, K.T.,Yamashita, S.Y.,Sakurai, T.S.,Kataoka, K.K.	Structure of the M305I mutant of CueO	To Be Published	0	0	0	0	
7F19		Structure of the G304E mutant of CueO	2021-06-08	2022-06-15	Takata, S.T.,Kawano, T.K.,Nakata, S.N.,Takado, K.T.,Imaizumi, R.I.,Sakai, N.S.,Takeshita, K.T.,Yamashita, S.Y.,Sakurai, T.S.,Kataoka, K.K.	Structure of the G304E mutant of CueO	To Be Published	0	0	0	0	
7FEE	35637350	Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1	2021-07-19	2022-06-15	Yang, X.,Wang, X.,Xu, Z.,Wu, C.,Zhou, Y.,Wang, Y.,Lin, G.,Li, K.,Wu, M.,Xia, A.,Liu, J.,Cheng, L.,Zou, J.,Yan, W.,Shao, Z.,Yang, S.	Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.	Nat.Chem.Biol.	2022	18	831	840	
7F2X	35831322	Crystal structure of MEK1 C121S mutant	2021-06-15	2022-06-22	Kubota, Y.,Fujioka, Y.,Patil, A.,Takagi, Y.,Matsubara, D.,Iijima, M.,Momose, I.,Naka, R.,Nakai, K.,Noda, N.N.,Takekawa, M.	Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.	Nat Commun	2022	13	4063	4063	
7W7B	35767641	Heme exporter HrtBA in complex with protoporphyrin IX containing manganese(III), high resolution data	2021-12-04	2022-06-22	Nakamura, H.,Hisano, T.,Rahman, M.M.,Tosha, T.,Shirouzu, M.,Shiro, Y.	Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7F5Q	36099055	An active enzyme from the plant Viola yedoensis	2021-06-22	2022-06-29	Hu, S.,El Sahili, A.,Kishore, S.,Wong, Y.H.,Hemu, X.,Goh, B.C.,Zhipei, S.,Wang, Z.,Tam, J.P.,Liu, C.F.,Lescar, J.	Structural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase.	Plant Cell	2022	34	4936	4949	
7V3D	35739195	Complex structure of serine hydroxymethyltransferase from Enterococcus faecium and its inhibitor	2021-08-10	2022-07-06	Makino, Y.,Oe, C.,Iwama, K.,Suzuki, S.,Nishiyama, A.,Hasegawa, K.,Okuda, H.,Hirata, K.,Ueno, M.,Kawaji, K.,Sasano, M.,Usui, E.,Hosaka, T.,Yabuki, Y.,Shirouzu, M.,Katsumi, M.,Murayama, K.,Hayashi, H.,Kodama, E.N.	Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.	Commun Biol	2022	5	619	619	
7VMW		Crystal structure of LimF prenyltransferase bound with a peptide substrate and GSPP	2021-10-09	2022-08-03	Zhang, Y.,Hamada, K.,Nguyen, D.T.,Inoue, S.,Satake, M.,Kobayashi, S.,Okada, C.,Ogata, K.,Okada, M.,Sengoku, T.,Goto, Y.,Suga, H.	LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates	Nat Catal	2022	0	0	0	
7VG7	35981535	Plexin B1 extracellular fragment in complex with lasso-grafted PB1m6A9 peptide	2021-09-14	2022-08-17	Sugano-Nakamura, N.,Matoba, K.,Hirose, M.,Bashiruddin, N.K.,Matsunaga, Y.,Yamashita, K.,Hirata, K.,Yamamoto, M.,Arimori, T.,Suga, H.,Takagi, J.	De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function.	Structure	2022	30	1411	0	
7W6X	36001659	Crystal structure of E. coli RseP in complex with batimastat	2021-12-02	2022-09-07	Imaizumi, Y.,Takanuki, K.,Miyake, T.,Takemoto, M.,Hirata, K.,Hirose, M.,Oi, R.,Kobayashi, T.,Miyoshi, K.,Aruga, R.,Yokoyama, T.,Katagiri, S.,Matsuura, H.,Iwasaki, K.,Kato, T.,Kaneko, M.K.,Kato, Y.,Tajiri, M.,Akashi, S.,Nureki, O.,Hizukuri, Y.,Akiyama, Y.,Nogi, T.	Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.	Sci Adv	2022	8	0	0	
7W6Y	36001659	Crystal structure of Kangiella koreensis RseP orthologue in complex with batimastat in space group P1	2021-12-02	2022-09-07	Imaizumi, Y.,Takanuki, K.,Miyake, T.,Takemoto, M.,Hirata, K.,Hirose, M.,Oi, R.,Kobayashi, T.,Miyoshi, K.,Aruga, R.,Yokoyama, T.,Katagiri, S.,Matsuura, H.,Iwasaki, K.,Kato, T.,Kaneko, M.K.,Kato, Y.,Tajiri, M.,Akashi, S.,Nureki, O.,Hizukuri, Y.,Akiyama, Y.,Nogi, T.	Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.	Sci Adv	2022	8	0	0	
7W6Z	36001659	Crystal structure of Kangiella koreensis RseP orthologue in complex with batimastat in space group P21	2021-12-02	2022-09-07	Imaizumi, Y.,Takanuki, K.,Miyake, T.,Takemoto, M.,Hirata, K.,Hirose, M.,Oi, R.,Kobayashi, T.,Miyoshi, K.,Aruga, R.,Yokoyama, T.,Katagiri, S.,Matsuura, H.,Iwasaki, K.,Kato, T.,Kaneko, M.K.,Kato, Y.,Tajiri, M.,Akashi, S.,Nureki, O.,Hizukuri, Y.,Akiyama, Y.,Nogi, T.	Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.	Sci Adv	2022	8	0	0	
7W36	36107218	Crystal structure of human Atg5 complexed with a stapled peptide	2021-11-25	2022-09-21	Cui, J.,Ogasawara, Y.,Kurata, I.,Matoba, K.,Fujioka, Y.,Noda, N.N.,Shibasaki, M.,Watanabe, T.	Targeting the ATG5-ATG16L1 Protein-Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition.	J.Am.Chem.Soc.	2022	144	17671	17679	
7X4N	36065637	Crystal Structure of C. elegans kinesin-4 KLP-12 complexed with tubulin and DARPin	2022-03-03	2022-09-21	Taguchi, S.,Nakano, J.,Imasaki, T.,Kita, T.,Saijo-Hamano, Y.,Sakai, N.,Shigematsu, H.,Okuma, H.,Shimizu, T.,Nitta, E.,Kikkawa, S.,Mizobuchi, S.,Niwa, S.,Nitta, R.	Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex.	Elife	2022	11	0	0	
7YNU	36142308	Crystal structure of Hen Egg white LYSOZYME introduced with O-(2-nitrobenzyl)-L-tyrosine	2022-08-01	2022-09-21	Hosaka, T.,Katsura, K.,Ishizuka-Katsura, Y.,Hanada, K.,Ito, K.,Tomabechi, Y.,Inoue, M.,Akasaka, R.,Takemoto, C.,Shirouzu, M.	Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography.	Int J Mol Sci	2022	23	0	0	
7YNV	36142308	Crystal structure of photolysed Hen Egg white LYSOZYME introduced with O-(2-nitrobenzyl)-L-tyrosine	2022-08-01	2022-09-21	Hosaka, T.,Katsura, K.,Ishizuka-Katsura, Y.,Hanada, K.,Ito, K.,Tomabechi, Y.,Inoue, M.,Akasaka, R.,Takemoto, C.,Shirouzu, M.	Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography.	Int J Mol Sci	2022	23	0	0	
7YNW	36142308	Crystal structure of O-(2-nitrobenzyl)-L-tyrosine-tRNA sythetase in complex with O-(2-nitrobenzyl)-L-tyrosine	2022-08-01	2022-09-21	Hosaka, T.,Katsura, K.,Ishizuka-Katsura, Y.,Hanada, K.,Ito, K.,Tomabechi, Y.,Inoue, M.,Akasaka, R.,Takemoto, C.,Shirouzu, M.	Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography.	Int J Mol Sci	2022	23	0	0	
7WXX	36137271	Crystal structure of human MMP-7 in complex with inhibitor	2022-02-15	2022-10-05	Tabuse, H.,Abe-Sato, K.,Kanazawa, H.,Yashiro, M.,Tamura, Y.,Kamitani, M.,Hitaka, K.,Gunji, E.,Mitani, A.,Kojima, N.,Oka, Y.	Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides.	J.Med.Chem.	2022	65	13253	13263	
7VPE		Falcilysin in complex with A1	2021-10-16	2022-10-19	Lin, J.Q.,Lescar, J.	Title is not available yet as we are preparing the manuscript. Will update again once the paper is out.	To Be Published	0	0	0	0	
7W8U	35074664	Crystal Structure of Indole Prenyltransferase IptA	2021-12-08	2022-10-19	Suemune, H.,Nishimura, D.,Mizutani, K.,Sato, Y.,Hino, T.,Takagi, H.,Shiozaki-Sato, Y.,Takahashi, S.,Nagano, S.	Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity.	Biochem.Biophys.Res.Commun.	2022	593	144	150	
7W8V	35074664	DMSPP- and Trp-bound 6-dimethylallyl tryptophan synthase, IptA	2021-12-08	2022-10-19	Suemune, H.,Nishimura, D.,Mizutani, K.,Sato, Y.,Hino, T.,Takagi, H.,Shiozaki-Sato, Y.,Takahashi, S.,Nagano, S.	Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity.	Biochem.Biophys.Res.Commun.	2022	593	144	150	
7W8X	35074664	DMSPP- and 6-Me-Trp-bound dimethylallyl tryptophan synthase, IptA	2021-12-08	2022-10-19	Suemune, H.,Nishimura, D.,Mizutani, K.,Sato, Y.,Hino, T.,Takagi, H.,Shiozaki-Sato, Y.,Takahashi, S.,Nagano, S.	Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity.	Biochem.Biophys.Res.Commun.	2022	593	144	150	
7XZQ	36282922	Crystal structure of TNIK-thiopeptide TP1 complex	2022-06-03	2022-10-26	Vinogradov, A.A.,Zhang, Y.,Hamada, K.,Chang, J.S.,Okada, C.,Nishimura, H.,Terasaka, N.,Goto, Y.,Ogata, K.,Sengoku, T.,Onaka, H.,Suga, H.	De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.	J.Am.Chem.Soc.	2022	144	20332	20341	
7XZR	36282922	Crystal structure of TNIK-AMPPNP-thiopeptide TP15 complex	2022-06-03	2022-10-26	Vinogradov, A.A.,Zhang, Y.,Hamada, K.,Chang, J.S.,Okada, C.,Nishimura, H.,Terasaka, N.,Goto, Y.,Ogata, K.,Sengoku, T.,Onaka, H.,Suga, H.	De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.	J.Am.Chem.Soc.	2022	144	20332	20341	
7XRR	36417909	Crystal structure of the human OX2R bound to the insomnia drug lemborexant.	2022-05-11	2022-11-23	Asada, H.,Im, D.,Hotta, Y.,Yasuda, S.,Murata, T.,Suno, R.,Iwata, S.	Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.	Structure	2022	30	1582	0	
7W3O	36543799	Crystal structure of human CYB5R3	2021-11-25	2022-12-07	Ishimura, R.,El-Gowily, A.H.,Noshiro, D.,Komatsu-Hirota, S.,Ono, Y.,Shindo, M.,Hatta, T.,Abe, M.,Uemura, T.,Lee-Okada, H.C.,Mohamed, T.M.,Yokomizo, T.,Ueno, T.,Sakimura, K.,Natsume, T.,Sorimachi, H.,Inada, T.,Waguri, S.,Noda, N.N.,Komatsu, M.	The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.	Nat Commun	2022	13	7857	7857	
8H5E	36465111	Crystal structure of the MgtE TM domain in complex with Ca2+ ions at 2.5 angstrom resolution	2022-10-13	2022-12-07	Teng, X.,Sheng, D.,Wang, J.,Yu, Y.,Hattori, M.	Ion selectivity mechanism of the MgtE channel for Mg 2+ over Ca 2 .	Iscience	2022	25	105565	105565	
7XQM	36417431	InDel-mutant short chain Dehydrogenase bound to SAH	2022-05-08	2022-12-21	Toledo-Patino, S.,Pascarelli, S.,Uechi, G.I.,Laurino, P.	Insertions and deletions mediated functional divergence of Rossmann fold enzymes.	Proc.Natl.Acad.Sci.USA	2022	119	0	0	
7WY2	36519803	Structure of the Oxomolybdenum Mesoporphyrin IX-Reconstituted CYP102A1 F87A Mutant Haem Domain with N-Enanthyl-L-Prolyl-L-Phenylalanine in complex with Styrene	2022-02-15	2023-01-04	Suzuki, K.,Stanfield, J.K.,Omura, K.,Shisaka, Y.,Ariyasu, S.,Kasai, C.,Aiba, Y.,Sugimoto, H.,Shoji, O.	A Compound I Mimic Reveals the Transient Active Species of a Cytochrome P450 Enzyme: Insight into the Stereoselectivity of P450-Catalysed Oxidations.	Angew.Chem.Int.Ed.Engl.	2023	62	0	0	
7XHR	36192567	Crystal structure of Wild Type Cypovirus Polyhedra produced by cell-free protein synthesis	2022-04-10	2023-02-01	Abe, S.,Tanaka, J.,Kojima, M.,Kanamaru, S.,Hirata, K.,Yamashita, K.,Kobayashi, A.,Ueno, T.	Cell-free protein crystallization for nanocrystal structure determination.	Sci Rep	2022	12	16031	16031	
7XHS	36192567	Crystal structure of CipA crystal produced by cell-free protein synthesis	2022-04-10	2023-02-01	Abe, S.,Tanaka, J.,Kojima, M.,Kanamaru, S.,Hirata, K.,Yamashita, K.,Kobayashi, A.,Ueno, T.	Cell-free protein crystallization for nanocrystal structure determination.	Sci Rep	2022	12	16031	16031	
7XWS	36192567	Crystal structure of Wild Type Cypovirus Polyhedra produced by cell-free protein synthesis with small volume	2022-05-27	2023-02-01	Abe, S.,Tanaka, J.,Kojima, M.,Kanamaru, S.,Hirata, K.,Yamashita, K.,Kobayashi, A.,Ueno, T.	Cell-free protein crystallization for nanocrystal structure determination.	Sci Rep	2022	12	16031	16031	
7YMP	36307380	Crystal structure of lysoplasmalogen specific phospholipase D	2022-07-29	2023-02-08	Hamana, H.,Yasutake, Y.,Kato-Murayama, M.,Hosaka, T.,Shirouzu, M.,Sakasegawa, S.I.,Sugimori, D.,Murayama, K.	Structural basis for the substrate specificity switching of lysoplasmalogen-specific phospholipase D from Thermocrispum sp. RD004668.	Biosci.Biotechnol.Biochem.	2022	87	74	81	
7YMQ	36307380	Crystal structure of lysoplasmalogen specific phopholipase D, F211L mutant	2022-07-29	2023-02-08	Hamana, H.,Yasutake, Y.,Kato-Murayama, M.,Hosaka, T.,Shirouzu, M.,Sakasegawa, S.I.,Sugimori, D.,Murayama, K.	Structural basis for the substrate specificity switching of lysoplasmalogen-specific phospholipase D from Thermocrispum sp. RD004668.	Biosci.Biotechnol.Biochem.	2022	87	74	81	
8H70	36732678	Crystal structure of the catalytic ATP-binding domain of the PhoR sensor histidine kinase from Vibrio cholera	2022-10-18	2023-02-15	Jia, R.,Zhao, Y.,Hattori, M.	Crystal structure of the catalytic ATP-binding domain of the PhoR sensor histidine kinase.	Proteins	2023	91	999	1004	
8HPJ	37012268	Crystal structure of the bacterial oxalate transporter OxlT in a ligand-free outward-facing form	2022-12-12	2023-02-15	Jaunet-Lahary, T.,Shimamura, T.,Hayashi, M.,Nomura, N.,Hirasawa, K.,Shimizu, T.,Yamashita, M.,Tsutsumi, N.,Suehiro, Y.,Kojima, K.,Sudo, Y.,Tamura, T.,Iwanari, H.,Hamakubo, T.,Iwata, S.,Okazaki, K.I.,Hirai, T.,Yamashita, A.	Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota.	Nat Commun	2023	14	1730	1730	
7WYR	36594419	Crystal structure of Cypovirus Polyhedra mutant fused with CLN025	2022-02-16	2023-02-22	Kojima, M.,Abe, S.,Furuta, T.,Tran, D.P.,Hirata, K.,Yamashita, K.,Hishikawa, Y.,Kitao, A.,Ueno, T.	Engineering of an in-cell protein crystal for fastening a metastable conformation of a target miniprotein.	Biomater Sci	2023	11	1350	1357	
7YTB	36859551	Crystal structure of Kin4B8	2022-08-14	2023-03-15	Chazan, A.,Das, I.,Fujiwara, T.,Murakoshi, S.,Rozenberg, A.,Molina-Marquez, A.,Sano, F.K.,Tanaka, T.,Gomez-Villegas, P.,Larom, S.,Pushkarev, A.,Malakar, P.,Hasegawa, M.,Tsukamoto, Y.,Ishizuka, T.,Konno, M.,Nagata, T.,Mizuno, Y.,Katayama, K.,Abe-Yoshizumi, R.,Ruhman, S.,Inoue, K.,Kandori, H.,Leon, R.,Shihoya, W.,Yoshizawa, S.,Sheves, M.,Nureki, O.,Beja, O.	Phototrophy by antenna-containing rhodopsin pumps in aquatic environments.	Nature	2023	615	535	540	
8IFJ	37047230	Crystal structure of pyrrolysyl-tRNA synthetase from methanogenic archaeon ISO4-G1	2023-02-18	2023-03-15	Yanagisawa, T.,Seki, E.,Tanabe, H.,Fujii, Y.,Sakamoto, K.,Yokoyama, S.	Crystal Structure of Pyrrolysyl-tRNA Synthetase from a Methanogenic Archaeon ISO4-G1 and Its Structure-Based Engineering for Highly-Productive Cell-Free Genetic Code Expansion with Non-Canonical Amino Acids.	Int J Mol Sci	2023	24	0	0	
8GNE	36894319	Crystal structure of human adenosine A2A receptor in complex with an insurmountable inverse agonist, KW-6356.	2022-08-23	2023-03-22	Ohno, Y.,Suzuki, M.,Asada, H.,Kanda, T.,Saki, M.,Miyagi, H.,Yasunaga, M.,Suno, C.,Iwata, S.,Saito, J.I.,Uchida, S.	In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A 2A Receptor Antagonist/Inverse Agonist.	Mol.Pharmacol.	2023	103	311	324	
8GNG	36894319	Crystal structure of human adenosine A2A receptor in complex with istradefylline.	2022-08-23	2023-03-22	Ohno, Y.,Suzuki, M.,Asada, H.,Kanda, T.,Saki, M.,Miyagi, H.,Yasunaga, M.,Suno, C.,Iwata, S.,Saito, J.I.,Uchida, S.	In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A 2A Receptor Antagonist/Inverse Agonist.	Mol.Pharmacol.	2023	103	311	324	
7XEP		SufS with L-propargylglycine	2022-03-31	2023-04-05	Nakamura, R.,Takahashi, Y.,Fujishiro, T.	Inhibition mechanism of SufS by L-propargylglycine	to be published	0	0	0	0	
7XK9	37059717	Structure of human beta2 adrenergic receptor bound to constrained isoproterenol	2022-04-19	2023-04-26	Xu, X.,Shonberg, J.,Kaindl, J.,Clark, M.J.,Stossel, A.,Maul, L.,Mayer, D.,Hubner, H.,Hirata, K.,Venkatakrishnan, A.J.,Dror, R.O.,Kobilka, B.K.,Sunahara, R.K.,Liu, X.,Gmeiner, P.	Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.	Nat Commun	2023	14	2138	2138	
7XKA	37059717	Structure of human beta2 adrenergic receptor bound to constrained epinephrine	2022-04-19	2023-04-26	Xu, X.,Shonberg, J.,Kaindl, J.,Clark, M.J.,Stossel, A.,Maul, L.,Mayer, D.,Hubner, H.,Hirata, K.,Venkatakrishnan, A.J.,Dror, R.O.,Kobilka, B.K.,Sunahara, R.K.,Liu, X.,Gmeiner, P.	Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.	Nat Commun	2023	14	2138	2138	
7YDO	37192628	Crystal structure of Atg44	2022-07-04	2023-05-17	Fukuda, T.,Furukawa, K.,Maruyama, T.,Yamashita, S.I.,Noshiro, D.,Song, C.,Ogasawara, Y.,Okuyama, K.,Alam, J.M.,Hayatsu, M.,Saigusa, T.,Inoue, K.,Ikeda, K.,Takai, A.,Chen, L.,Lahiri, V.,Okada, Y.,Shibata, S.,Murata, K.,Klionsky, D.J.,Noda, N.N.,Kanki, T.	The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy.	Mol.Cell	2023	83	2045	0	
8HD2	36614187	Crystal structure of SAM dependent methyltransferase encoded in type II fatty acid biosynthesis gene cluster from ladderane lipid producing anammox bacteria	2022-11-03	2023-05-17	Uegaki, T.,Takei, T.,Yamaguchi, S.,Fujiyama, K.,Sato, Y.,Hino, T.,Nagano, S.	Anammox Bacterial S -Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins.	Int J Mol Sci	2023	24	0	0	
8IF2	37169744	Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BQ.1.1 variant spike protein in complex with its receptor ACE2	2023-02-17	2023-05-17	Ito, J.,Suzuki, R.,Uriu, K.,Itakura, Y.,Zahradnik, J.,Kimura, K.T.,Deguchi, S.,Wang, L.,Lytras, S.,Tamura, T.,Kida, I.,Nasser, H.,Shofa, M.,Begum, M.M.,Tsuda, M.,Oda, Y.,Suzuki, T.,Sasaki, J.,Sasaki-Tabata, K.,Fujita, S.,Yoshimatsu, K.,Ito, H.,Nao, N.,Asakura, H.,Nagashima, M.,Sadamasu, K.,Yoshimura, K.,Yamamoto, Y.,Nagamoto, T.,Kuramochi, J.,Schreiber, G.,Saito, A.,Matsuno, K.,Takayama, K.,Hashiguchi, T.,Tanaka, S.,Fukuhara, T.,Ikeda, T.,Sato, K.	Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant.	Nat Commun	2023	14	2671	2671	
8GQ1	37550885	HyHEL10 Fab complexed with hen egg lysozyme carrying arginine cluster in framework region of light chain.	2022-08-28	2023-08-30	Maeta, S.,Nakakido, M.,Matsuura, H.,Sakai, N.,Hirata, K.,Kuroda, D.,Fukunaga, A.,Tsumoto, K.	Arginine cluster introduction on framework region in anti-lysozyme antibody improved association rate constant by changing conformational diversity of CDR loops.	Protein Sci.	2023	32	0	0	
8IIA	37699394	Crystal structure of the oligomeric state of the extracellular domain of human myelin protein zero(MPZ/P0)	2023-02-24	2023-08-30	Sakakura, M.,Tanabe, M.,Mori, M.,Takahashi, H.,Mio, K.	Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero.	Structure	2023	31	1452	0	
7YTX	37544422	Crystal structure of TLR8 in complex with its antagonist	2022-08-16	2023-09-27	Ishizaka, S.T.,Hawkins, L.,Chen, Q.,Tago, F.,Yagi, T.,Sakaniwa, K.,Zhang, Z.,Shimizu, T.,Shirato, M.	A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus.	Eur.J.Pharmacol.	2023	957	175962	175962	
8H2M	38182597	gp96 RNA polymerase from P23-45 phage (crystal 1)	2022-10-06	2023-10-11	Chaban, A.,Minakhin, L.,Goldobina, E.,Bae, B.,Hao, Y.,Borukhov, S.,Putzeys, L.,Boon, M.,Kabinger, F.,Lavigne, R.,Makarova, K.S.,Koonin, E.V.,Nair, S.K.,Tagami, S.,Severinov, K.,Sokolova, M.L.	Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail.	Nat Commun	2024	15	317	317	
8H4M		Crystal Structure of GTP-bound Irgb6_T95D mutant	2022-10-10	2023-10-18	Okuma, H.,Saijo-Hamano, Y.,Sherif, A.A.,Hashizaki, E.,Sakai, N.,Kato, K.,Imasaki, T.,Nitta, E.,Sasai, M.,Kosako, H.,Standley, D.M.,Yamamoto, M.,Nitta, R.	Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I	To Be Published	0	0	0	0	
8H4O		Crystal Structure of nucleotide-free Irgb6_T95D mutant	2022-10-11	2023-10-18	Okuma, H.,Saijo-Hamano, Y.,Sherif, A.A.,Hashizaki, E.,Sakai, N.,Kato, K.,Imasaki, T.,Nitta, E.,Sasai, M.,Kosako, H.,Standley, D.M.,Yamamoto, M.,Nitta, R.	Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I	To Be Published	0	0	0	0	
8H79		The crystal structure of cyanorhodopsin-II (CyR-II) P7104R from Nodosilinea nodulosa PCC 7104	2022-10-19	2023-10-25	Hasegawa, M.,Hosaka, T.,Kojima, K.,Nishimura, Y.,Kurihara, M.,Nakajima, Y.,Ishizuka-Katsura, Y.,Kimura-Someya, T.,Shirouzu, M.,Sudo, Y.,Yoshizawa, S.	Cyanorhodopsin-II: diverse proton-pumping rhodopsins in the cyanobacterial lineage illuminated by large-scale metagenomic	To Be Published	0	0	0	0	
8HAR		SAH-bound C-Methyltransferase Fur6 from Streptomyces sp. KO-3988	2022-10-26	2023-11-01	Noguchi, T.,Fan, Z.,Moriwaki, Y.,Yamamoto, H.,Nagata, R.,Tomita, T.,Terada, T.,Shimizu, K.,Nishiyama, M.,Kuzuyama, T.	Reductive biosynthesis of meroterpenoids via transient diazotization	To Be Published	0	0	0	0	
8JUD	37861435	Crystal structure of human MMP-7 in complex with inhibitor	2023-06-26	2023-11-01	Abe-Sato, K.,Tabuse, H.,Kanazawa, H.,Kamitani, M.,Endo, M.,Tokura, S.,Wakabayashi, S.,Yahara, T.,Takeda, T.,Hitaka, K.,Gunji, E.,Kojima, N.,Oka, Y.	Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.	J.Med.Chem.	2023	66	14653	14668	
8JUF	37861435	Crystal structure of human MMP-7 in complex with inhibitor	2023-06-26	2023-11-01	Abe-Sato, K.,Tabuse, H.,Kanazawa, H.,Kamitani, M.,Endo, M.,Tokura, S.,Wakabayashi, S.,Yahara, T.,Takeda, T.,Hitaka, K.,Gunji, E.,Kojima, N.,Oka, Y.	Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.	J.Med.Chem.	2023	66	14653	14668	
8JE4	37877712	Crystal structure of LimF prenyltransferase (H239G/W273T mutant) bound with the thiodiphosphate moiety of farnesyl S-thiolodiphosphate (FSPP)	2023-05-15	2023-11-08	Zhang, Y.,Hamada, K.,Satake, M.,Sengoku, T.,Goto, Y.,Suga, H.	Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases.	J.Am.Chem.Soc.	2023	145	23893	23898	
8HFP		Crystal structure of the methyl-CpG-binding domain of SETDB2 in complex with the cysteine-rich domain of C11orf46 protein	2022-11-11	2023-11-22	Mahana, Y.,Ariyoshi, M.,Nagao, K.,Obuse, C.,Shirakawa, M.	Structural Evidence for Protein Binding by the Methyl-CpG-Binding Domain of SETDB Proteins	To Be Published	0	0	0	0	
8KCM	38033054	MmCPDII-DNA complex containing low-dosage, light induced repaired DNA.	2023-08-08	2023-11-22	Maestre-Reyna, M.,Wang, P.H.,Nango, E.,Hosokawa, Y.,Saft, M.,Furrer, A.,Yang, C.H.,Gusti Ngurah Putu, E.P.,Wu, W.J.,Emmerich, H.J.,Caramello, N.,Franz-Badur, S.,Yang, C.,Engilberge, S.,Wranik, M.,Glover, H.L.,Weinert, T.,Wu, H.Y.,Lee, C.C.,Huang, W.C.,Huang, K.F.,Chang, Y.K.,Liao, J.H.,Weng, J.H.,Gad, W.,Chang, C.W.,Pang, A.H.,Yang, K.C.,Lin, W.T.,Chang, Y.C.,Gashi, D.,Beale, E.,Ozerov, D.,Nass, K.,Knopp, G.,Johnson, P.J.M.,Cirelli, C.,Milne, C.,Bacellar, C.,Sugahara, M.,Owada, S.,Joti, Y.,Yamashita, A.,Tanaka, R.,Tanaka, T.,Luo, F.,Tono, K.,Zarzycka, W.,Muller, P.,Alahmad, M.A.,Bezold, F.,Fuchs, V.,Gnau, P.,Kiontke, S.,Korf, L.,Reithofer, V.,Rosner, C.J.,Seiler, E.M.,Watad, M.,Werel, L.,Spadaccini, R.,Yamamoto, J.,Iwata, S.,Zhong, D.,Standfuss, J.,Royant, A.,Bessho, Y.,Essen, L.O.,Tsai, M.D.	Visualizing the DNA repair process by a photolyase at atomic resolution.	Science	2023	382	0	0	
8WSM	38116417	NLRP3 NACHT domain in complex with compound 32	2023-10-17	2023-11-22	Ohba, Y.,Adachi, K.,Furukawa, T.,Nishimaru, T.,Sakurai, K.,Masuo, R.,Inami, T.,Orita, T.,Akai, S.,Adachi, T.,Usui, K.,Hamada, Y.,Mori, M.,Kurimoto, T.,Wakashima, T.,Akiyama, Y.,Miyazaki, S.,Noji, S.	Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide.	Acs Med.Chem.Lett.	2023	14	1833	1838	
8K5V	37952596	Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor	2023-07-24	2023-12-06	Nishikawa-Shimono, R.,Kuwabara, M.,Fujisaki, S.,Matsuda, D.,Endo, M.,Kamitani, M.,Futamura, A.,Nomura, Y.,Yamaguchi-Sasaki, T.,Yabuuchi, T.,Yamaguchi, C.,Tanaka-Yamamoto, N.,Satake, S.,Abe-Sato, K.,Funayama, K.,Sakata, M.,Takahashi, S.,Hirano, K.,Fukunaga, T.,Uozumi, Y.,Kato, S.,Tamura, Y.,Nakamori, T.,Mima, M.,Mishima-Tsumagari, C.,Nozawa, D.,Imai, Y.,Asami, T.	Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.	Bioorg.Med.Chem.Lett.	2023	97	129541	129541	
8K5Y	37952596	Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor	2023-07-24	2023-12-06	Nishikawa-Shimono, R.,Kuwabara, M.,Fujisaki, S.,Matsuda, D.,Endo, M.,Kamitani, M.,Futamura, A.,Nomura, Y.,Yamaguchi-Sasaki, T.,Yabuuchi, T.,Yamaguchi, C.,Tanaka-Yamamoto, N.,Satake, S.,Abe-Sato, K.,Funayama, K.,Sakata, M.,Takahashi, S.,Hirano, K.,Fukunaga, T.,Uozumi, Y.,Kato, S.,Tamura, Y.,Nakamori, T.,Mima, M.,Mishima-Tsumagari, C.,Nozawa, D.,Imai, Y.,Asami, T.	Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.	Bioorg.Med.Chem.Lett.	2023	97	129541	129541	
8HQQ		Crystal structure of the glucose-binding protein SAR11_0769 from ""Candidatus Pelagibacter ubique"" HTCC1062 bound to glucose	2022-12-14	2023-12-27	Clifton, B.E.,Laurino, P.	Crystal structure of the glucose-binding protein SAR11_0769 from ""Candidatus Pelagibacter ubique"" HTCC1062 bound to glucose	To Be Published	0	0	0	0	
8HQR		Crystal structure of the arginine-/lysine-binding protein SAR11_1210 from 'Candidatus Pelagibacter ubique' HTCC1062 bound to arginine	2022-12-14	2023-12-27	Clifton, B.E.,Laurino, P.	Crystal structure of the arginine-/lysine-binding protein SAR11_1210 from 'Candidatus Pelagibacter ubique' HTCC1062 bound to arginine	To Be Published	0	0	0	0	
8WDT	38171234	Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)	2023-09-16	2024-01-17	Araya, T.,Matsuba, Y.,Suzuki, H.,Doura, T.,Nuemket, N.,Nango, E.,Yamamoto, M.,Im, D.,Asada, H.,Kiyonaka, S.,Iwata, S.	Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A 2A receptor.	Biochem.Biophys.Res.Commun.	2023	695	149393	149393	
8X35	38225831	Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form A)	2023-11-12	2024-02-07	Imaizumi, R.,Matsuura, H.,Yanai, T.,Takeshita, K.,Misawa, S.,Yamaguchi, H.,Sakai, N.,Miyagi-Inoue, Y.,Suenaga-Hiromori, M.,Waki, T.,Kataoka, K.,Nakayama, T.,Yamamoto, M.,Takahashi, S.,Yamashita, S.	Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato.	Chembiochem	2024	25	0	0	
8X36	38225831	Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form B)	2023-11-12	2024-02-07	Imaizumi, R.,Matsuura, H.,Yanai, T.,Takeshita, K.,Misawa, S.,Yamaguchi, H.,Sakai, N.,Miyagi-Inoue, Y.,Suenaga-Hiromori, M.,Waki, T.,Kataoka, K.,Nakayama, T.,Yamamoto, M.,Takahashi, S.,Yamashita, S.	Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato.	Chembiochem	2024	25	0	0	
8X37	38225831	Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP	2023-11-12	2024-02-07	Imaizumi, R.,Matsuura, H.,Yanai, T.,Takeshita, K.,Misawa, S.,Yamaguchi, H.,Sakai, N.,Miyagi-Inoue, Y.,Suenaga-Hiromori, M.,Waki, T.,Kataoka, K.,Nakayama, T.,Yamamoto, M.,Takahashi, S.,Yamashita, S.	Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato.	Chembiochem	2024	25	0	0	
8W7N	37922785	Crystal structure of the in-cell Cry1Aa purified from Bacillus thuringiensis	2023-08-31	2024-03-06	Tanaka, J.,Abe, S.,Hayakawa, T.,Kojima, M.,Yamashita, K.,Hirata, K.,Ueno, T.	Crystal structure of the in-cell Cry1Aa purified from Bacillus thuringiensis.	Biochem.Biophys.Res.Commun.	2023	685	149144	149144	
8J4C		YeeE(TsuA)-YeeD(TsuB) complex for thiosulfate uptake	2023-04-19	2024-03-27	Ikei, M.,Miyazaki, R.,Monden, K.,Naito, Y.,Takeuchi, A.,Takahashi, Y.,Tanaka, Y.,Ichikawa, M.,Tsukazaki, T.	Structure and function of YeeE-YeeD complex for sophisticated thiosulfate uptake	To Be Published	0	0	0	0	
8J4C		YeeE(TsuA)-YeeD(TsuB) complex for thiosulfate uptake	2023-04-19	2024-03-27	Ikei, M.,Miyazaki, R.,Monden, K.,Naito, Y.,Takeuchi, A.,Takahashi, Y.,Tanaka, Y.,Ichikawa, M.,Tsukazaki, T.	Structure and function of YeeE-YeeD complex for sophisticated thiosulfate uptake	To Be Published	0	0	0	0	
8K1R		YeeE(TsuA)-YeeD(TsuB) complex for thiosulfate uptake	2023-07-11	2024-03-27	Ikei, M.,Miyazaki, R.,Monden, K.,Naito, Y.,Takeuchi, A.,Takahashi, Y.S.,Tanaka, Y.,Ichikawa, M.,Tsukazaki, T.	Structure and function of YeeE-YeeD complex for sophisticated thiosulfate uptake	To Be Published	0	0	0	0	
8K1R		YeeE(TsuA)-YeeD(TsuB) complex for thiosulfate uptake	2023-07-11	2024-03-27	Ikei, M.,Miyazaki, R.,Monden, K.,Naito, Y.,Takeuchi, A.,Takahashi, Y.S.,Tanaka, Y.,Ichikawa, M.,Tsukazaki, T.	Structure and function of YeeE-YeeD complex for sophisticated thiosulfate uptake	To Be Published	0	0	0	0	
8WM0	38491946	Crystal structure of TNIK-thiopeptide wTP3 complex	2023-10-01	2024-03-27	Vinogradov, A.A.,Zhang, Y.,Hamada, K.,Kobayashi, S.,Ogata, K.,Sengoku, T.,Goto, Y.,Suga, H.	A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides.	J.Am.Chem.Soc.	2024	0	0	0	
8X2V		Crystal structure of the ancestral GH19 chitinase, Anc4+LoopII (P12K/N13H mutant)	2023-11-10	2024-04-03	Kozome, D.,Laurino, P.	Beyond the active site: The addition of a remote loop reveals a new complex biological function for chitinase enzymes	To Be Published	0	0	0	0	
8X2W		Crystal structure of the ancestral GH19 chitinase, Anc4+LoopII (P12K/N13H/S58T/N193G/Y194F/D197R)	2023-11-10	2024-04-03	Kozome, D.,Laurino, P.	Beyond the active site: The addition of a remote loop reveals a new complex biological function for chitinase enzymes	To Be Published	0	0	0	0	
8YK5	38503170	Structure of glycerophosphoethanolamine ethanolaminephosphodiesterase from Streptomyces sanglieri	2024-03-04	2024-04-03	Murayama, K.,Hosaka, T.,Shirouzu, M.,Sugimori, D.	Structure of a phosphodiesterase from Streptomyces sanglieri with a novel C-terminal domain.	Biochem.Biophys.Res.Commun.	2024	708	149784	149784	
8J9F		Structure of STG-hydrolyzing beta-glucosidase 1 (PSTG1)	2023-05-03	2024-04-10	Yanai, T.,Imaizumi, R.,Nakayama, T.,Yamashita, S.	Structural insights into a bacterial beta-glucosidase that is capable of degrading sesaminol triglucoside to produce sesaminol	To be published	0	0	0	0	
8J2Q		Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment	2023-04-15	2024-04-17	Kojima, M.,Abe, S.,Hirata, K.,Ueno, T.	Screening system for structure determination of intrinsically disordered protein using cell-free protein crystallization	To Be Published	0	0	0	0	
8K2F		Crystal structure of Group 1 oligosaccharide-releasing beta-N-acetylgalactosaminidase NgaCa from Cohnella abietis, apo 1 form	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2G		Crystal structure of Group 1 Oligosaccharide-releasing beta-N-acetylgalactosaminidase NgaCa from Cohnella abietis, apo 2 form	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2H		Crystal structure of Group 2Oligosaccharide/Monosaccharide-releasing beta-N-acetylhexosaminidase NgaAt from Arabidopsis thaliana in complex with GalNAc-thiazoline	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2I		Crystal structure of Group 2 Oligosaccharide/Monosaccharide-releasing beta-N-acetylhexosaminidase NgaAt from Arabidopsis thaliana in complex with GlcNAc-thiazoline	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2J		Crystal structure of Group 3 Oligosaccharide/Monosaccharide-releasing beta-N-acetylgalactosaminidase NgaDssm, apo form	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2K		Crystal structure of Group 3 Oligosaccharide/Monosaccharide-releasing beta-N-acetylgalactosaminidase NgaDssm in complex with GalNAc-thiazoline	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2L		Crystal structure of Group 4 Monosaccharide-releasing beta-N-acetylgalactosaminidase NgaP2 from Paenibacillus sp. TS12, apo form	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2M		Crystal structure of Group 4 Monosaccharide-releasing beta-N-acetylgalactosaminidase NgaP2 from Paenibacillus sp. TS12 in complex with GalNAc-thiazoline	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0	
8K2N		Crystal structure of Group 4 Monosaccharide-releasing beta-N-acetylgalactosaminidase NgaLy from Lacticaseibacillus yichunensis, apo form	2023-07-12	2024-04-24	Sumida, T.,Hiraoka, S.,Usui, K.,Ishiwata, A.,Sengoku, T.,Stubbs, K.A.,Tanaka, K.,Deguchi, S.,Fushinobu, S.,Nunoura, T.	Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome	To Be Published	0	0	0	0